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David Tweats

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David Tweats; Bernadette Bourdin Trunz; Els Torreele
Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).
Bernadette Bourdin Trunz; Rafał Jędrysiak; David Tweats; Reto Brun; Marcel Kaiser; Jerzy Suwiński; Els Torreele
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
Els Torreele; Bernadette Bourdin Trunz; David Tweats; Marcel Kaiser; Reto Brun; Guy Mazué; Michael A Bray; Bernard Pécoul
Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.

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All Publications

2012: David Tweats; Bernadette Bourdin Trunz; Els Torreele
Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).
Mutagenesis 2012;27(5):523-32.
2011: Bernadette Bourdin Trunz; Rafał Jędrysiak; David Tweats; Reto Brun; Marcel Kaiser; Jerzy Suwiński; Els Torreele
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
European journal of medicinal chemistry 2011;46(5):1524-35.
2010: Els Torreele; Bernadette Bourdin Trunz; David Tweats; Marcel Kaiser; Reto Brun; Guy Mazué; Michael A Bray; Bernard Pécoul
Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.
PLoS neglected tropical diseases 2010;4(12):e923.
2009: William M Gallagher; David Tweats; Jochen Koenig
Omic profiling for drug safety assessment: current trends and public-private partnerships.
Drug discovery today 2009;14(7-8):337-42.
2009: Anton Pozniak; Lutz Müller; Miklos Salgo; Judith K Jones; Peter Larson; David Tweats
Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.
AIDS research and therapy 2009;6():18.
2007: David Kirkland; Stefan Pfuhler; David Tweats; Marilyn Aardema; Raffaella Corvi; Firouz Darroudi; Azeddine Elhajouji; Hansruedi Glatt; Paul Hastwell; Makoto Hayashi; Peter Kasper; Stephan Kirchner; Anthony Lynch; Daniel Marzin; Daniela Maurici; Jean-Roch Meunier; Lutz Müller; Gerhard J Nohynek; James Parry; Elizabeth Parry; Veronique Thybaud; Raymond R Tice; Jan van Benthem; Philippe Vanparys; Paul White
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
Mutation research 2007;628(1):31-55.
2007: David Tweats; D Blakey; R H Heflich; A Jacobs; S D Jacobsen; T Morita; T Nohmi; M R O'Donovan; Y F Sasaki; Toshio Sofuni; Raymond R Tice
Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards.
Mutation research 2007;627(1):78-91.
2007: David Tweats; D Blakey; R H Heflich; A Jacobs; S D Jacobsen; T Morita; T Nohmi; M R O'Donovan; Y F Sasaki; Toshio Sofuni; Raymond R Tice
Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test.
Mutation research 2007;627(1):92-105.
2005: David Kirkland; leigh m henderson; D Marzin; Lutz Müller; J M Parry; G Speit; David Tweats; G M Williams
Testing strategies in mutagenicity and genetic toxicology: an appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes.
Mutation research 2005;588(2):88-105.
2005: Peter Kasper; Gerry Oliver; Beatriz Silva Lima; Thomas Singer; David Tweats
Joint EFPIA/CHMP SWP workshop: the Emerging Use of Omic Technologies for Regulatory Non-Clinical Safety Testing.
Pharmacogenomics 2005;6(2):181-4.
2003: Lutz Müller; David Blakey; Kerry L Dearfield; Sheila Galloway; Peggy Guzzie; Makoto Hayashi; Peter Kasper; David Kirkland; James T MacGregor; James M Parry; Leonard M Schechtman; Andrew Smith; Noriho Tanaka; David Tweats; Hiroshi Yamasaki
Strategy for genotoxicity testing and stratification of genotoxicity test results--report on initial activities of the IWGT Expert Group.
Mutation research 2003;540(2):177-81.
1999: Lutz Müller; Y Kikuchi; G Probst; Leonard M Schechtman; H Shimada; T Sofuni; David Tweats
ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact.
Mutation research 1999;436(3):195-225.