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Rodney Tweten

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Hemolysis

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Co-Publications
Name
16
Johnson, Arthur
12
Parker, Michael
10
Hotze, Eileen
9
Rossjohn, Jamie
8
Heuck, Alejandro
4
Wilson-Kubalek, Elizabeth
4
Giddings, Kara Sue
3
Buckley, Thomas
3
Feil, Susanne
3
Sellman, BR
3
Ramachandran, Rajesh
3
Polekhina, Galina
3
Shatursky, O
3
Shepard, LA
3
Sims, Peter

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Publications

TOP 3
LaChapelle Stephanie; Tweten Rodney K; Hotze Eileen M
Intermedilysin-receptor interactions during assembly of the pore complex: assembly intermediates increase host cell susceptibility to complement-mediated lysis.
Flanagan John J; Tweten Rodney K; Johnson Arthur E; Heuck Alejandro P
Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding.
Kennedy Catherine L; Lyras Dena; Cordner Leanne M; Melton-Witt Jody; Emmins John J; Tweten Rodney K; Rood Julian I
Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis.

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All Publications

2009: LaChapelle Stephanie; Tweten Rodney K; Hotze Eileen M
Intermedilysin-receptor interactions during assembly of the pore complex: assembly intermediates increase host cell susceptibility to complement-mediated lysis.
The Journal of biological chemistry 2009;284(19):12719-26.
2009: Flanagan John J; Tweten Rodney K; Johnson Arthur E; Heuck Alejandro P
Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding.
Biochemistry 2009;48(18):3977-87.
2009: Kennedy Catherine L; Lyras Dena; Cordner Leanne M; Melton-Witt Jody; Emmins John J; Tweten Rodney K; Rood Julian I
Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis.
Infection and immunity 2009;77(3):943-51.
2008: Farrand Stephen; Hotze Eileen; Friese Paul; Hollingshead Susan K; Smith David F; Cummings Richard D; Dale George L; Tweten Rodney K
Characterization of a streptococcal cholesterol-dependent cytolysin with a lewis y and b specific lectin domain.
Biochemistry 2008;47(27):7097-107.
2008: Hu Weiguo; Ferris Sean P; Tweten Rodney K; Wu Gongxiong; Radaeva Svetlana; Gao Bin; Bronson Roderick T; Halperin Jose A; Qin Xuebin
Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin.
Nature medicine 2008;14(1):98-103.
2007: Soltani Casie E; Hotze Eileen M; Johnson Arthur E; Tweten Rodney K
Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20226-31.
2007: Soltani Casie E; Hotze Eileen M; Johnson Arthur E; Tweten Rodney K
Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin.
The Journal of biological chemistry 2007;282(21):15709-16.
2007: Rossjohn Jamie; Polekhina Galina; Feil Susanne C; Morton Craig J; Tweten Rodney K; Parker Michael W
Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins.
Journal of molecular biology 2007;367(5):1227-36.
2006: Melton-Witt Jody A; Bentsen Lori M; Tweten Rodney K
Identification of functional domains of Clostridium septicum alpha toxin.
Biochemistry 2006;45(48):14347-54.
2006: Salles Isabelle I; Voth Daniel E; Ward Sabrina C; Averette Kathleen M; Tweten Rodney K; Bradley Kenneth A; Ballard Jimmy D
Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1.
Cellular microbiology 2006;8(8):1272-81.
2005: Dang Thanh X; Milligan Ronald A; Tweten Rodney K; Wilson-Kubalek Elizabeth M
Helical crystallization on nickel-lipid nanotubes: perfringolysin O as a model protein.
Journal of structural biology 2005;152(2):129-39.
2005: Tweten Rodney K
Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins.
Infection and immunity 2005;73(10):6199-209.
2005: Schuerch Daniel W; Wilson-Kubalek Elizabeth M; Tweten Rodney K
Molecular basis of listeriolysin O pH dependence.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12537-42.
2005: Ramachandran Rajesh; Tweten Rodney K; Johnson Arthur E
The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7139-44.
2005: Dang Thanh X; Hotze Eileen M; Rouiller Isabelle; Tweten Rodney K; Wilson-Kubalek Elizabeth M
Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy.
Journal of structural biology 2005;150(1):100-8.
2005: Zheng Zhifeng; Tweten Rodney K; Mensa-Wilmot Kojo
Intracellular glycosylphosphatidylinositols accumulate on endosomes: toxicity of alpha-toxin to Leishmania major.
Eukaryotic cell 2005;4(3):556-66.
2005: Polekhina Galina; Giddings Kara Sue; Tweten Rodney K; Parker Michael W
Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):600-5.
2004: Giddings Kara S; Zhao Ji; Sims Peter J; Tweten Rodney K
Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin.
Nature structural & molecular biology 2004;11(12):1173-8.
2004: Zheng Zhifeng; Butler Kimberly D; Tweten Rodney K; Mensa-Wilmot Kojo
Endosomes, glycosomes, and glycosylphosphatidylinositol catabolism in Leishmania major.
The Journal of biological chemistry 2004;279(40):42106-13.
2004: Czajkowsky Daniel M; Hotze Eileen M; Shao Zhifeng; Tweten Rodney K
Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane.
The EMBO journal 2004;23(16):3206-15.
2004: Ramachandran Rajesh; Tweten Rodney K; Johnson Arthur E
Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment.
Nature structural & molecular biology 2004;11(8):697-705.
2004: Melton Jody A; Parker Michael W; Rossjohn Jamie; Buckley J Thomas; Tweten Rodney K
The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin.
The Journal of biological chemistry 2004;279(14):14315-22.
2004: Polekhina Galina; Giddings Kara Sue; Tweten Rodney K; Parker Michael W
Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):347-9.
2003: Mourez Michael; Yan Ming; Lacy D Borden; Dillon Lisa; Bentsen Lori; Marpoe Amy; Maurin Clémence; Hotze Eileen; Wigelsworth Darran; Pimental Ruth-Anne; Ballard Jimmy D; Collier R John; Tweten Rodney K
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):13803-8.
2003: Giddings Kara S; Johnson Arthur E; Tweten Rodney K
Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11315-20.
2003: Heuck Alejandro P; Tweten Rodney K; Johnson Arthur E
Assembly and topography of the prepore complex in cholesterol-dependent cytolysins.
The Journal of biological chemistry 2003;278(33):31218-25.
2002: Ramachandran Rajesh; Heuck Alejandro P; Tweten Rodney K; Johnson Arthur E
Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin.
Nature structural biology 2002;9(11):823-7.
2002: Wichroski Michael J; Melton Jody A; Donahue Carolyn G; Tweten Rodney K; Ward Gary E
Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins.
Infection and immunity 2002;70(8):4353-61.
2002: Hotze Eileen M; Heuck Alejandro P; Czajkowsky Daniel M; Shao Zhifeng; Johnson Arthur E; Tweten Rodney K
Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin.
The Journal of biological chemistry 2002;277(13):11597-605.
2001: Tweten R K
Clostridium perfringens beta toxin and Clostridium septicum alpha toxin: their mechanisms and possible role in pathogenesis.
Veterinary microbiology 2001;82(1):1-9.
2001: Heuck A P; Tweten R K; Johnson A E
Beta-barrel pore-forming toxins: intriguing dimorphic proteins.
Biochemistry 2001;40(31):9065-73.
2001: Hotze E M; Wilson-Kubalek E M; Rossjohn J; Parker M W; Johnson A E; Tweten R K
Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate.
The Journal of biological chemistry 2001;276(11):8261-8.
2001: Tweten R K; Parker M W; Johnson A E
The cholesterol-dependent cytolysins.
Current topics in microbiology and immunology 2001;257():15-33.
2000: Heuck A P; Hotze E M; Tweten R K; Johnson A E
Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes.
Molecular cell 2000;6(5):1233-42.
2000: Shatursky O; Bayles R; Rogers M; Jost B H; Songer J G; Tweten R K
Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers.
Infection and immunity 2000;68(10):5546-51.
2000: Shepard L A; Shatursky O; Johnson A E; Tweten R K
The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins.
Biochemistry 2000;39(33):10284-93.
1999: Shatursky O; Heuck A P; Shepard L A; Rossjohn J; Parker M W; Johnson A E; Tweten R K
The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins.
Cell 1999;99(3):293-9.
1999: Gordon V M; Nelson K L; Buckley J T; Stevens V L; Tweten R K; Elwood P C; Leppla S H
Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.
The Journal of biological chemistry 1999;274(38):27274-80.
1999: Diep D B; Nelson K L; Lawrence T S; Sellman B R; Tweten R K; Buckley J T
Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein.
Molecular microbiology 1999;31(3):785-94.
1998: Gilbert R J; Rossjohn J; Parker M W; Tweten R K; Morgan P J; Mitchell T J; Errington N; Rowe A J; Andrew P W; Byron O
Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae.
Journal of molecular biology 1998;284(4):1223-37.
1998: Rossjohn J; Gilbert R J; Crane D; Morgan P J; Mitchell T J; Rowe A J; Andrew P W; Paton J C; Tweten R K; Parker M W
The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.
Journal of molecular biology 1998;284(2):449-61.
1998: Shepard L A; Heuck A P; Hamman B D; Rossjohn J; Parker M W; Ryan K R; Johnson A E; Tweten R K
Identification of a membrane-spanning domain of the thiol-activated pore-forming toxin Clostridium perfringens perfringolysin O: an alpha-helical to beta-sheet transition identified by fluorescence spectroscopy.
Biochemistry 1998;37(41):14563-74.
1997: Gordon V M; Benz R; Fujii K; Leppla S H; Tweten R K
Clostridium septicum alpha-toxin is proteolytically activated by furin.
Infection and immunity 1997;65(10):4130-4.
1997: Sellman B R; Tweten R K
The propeptide of Clostridium septicum alpha toxin functions as an intramolecular chaperone and is a potent inhibitor of alpha toxin-dependent cytolysis.
Molecular microbiology 1997;25(3):429-40.
1997: Rossjohn J; Feil S C; McKinstry W J; Tweten R K; Parker M W
Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form.
Cell 1997;89(5):685-92.
1997: Sellman B R; Kagan B L; Tweten R K
Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin.
Molecular microbiology 1997;23(3):551-8.
1996: Feil S C; Rossjohn J; Rohde K; Tweten R K; Parker M W
Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin.
FEBS letters 1996;397(2-3):290-2.
1995: Ballard J; Crabtree J; Roe B A; Tweten R K
The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin.
Infection and immunity 1995;63(1):340-4.
1994: Johnson S; Driks M R; Tweten R K; Ballard J; Stevens D L; Anderson D J; Janoff E N
Clinical courses of seven survivors of Clostridium septicum infection and their immunologic responses to alpha toxin.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1994;19(4):761-4.
1993: Ballard J; Sokolov Y; Yuan W L; Kagan B L; Tweten R K
Activation and mechanism of Clostridium septicum alpha toxin.
Molecular microbiology 1993;10(3):627-34.
1992: Ballard J; Bryant A; Stevens D; Tweten R K
Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum.
Infection and immunity 1992;60(3):784-90.
1991: Tweten R K; Harris R W; Sims P J
Isolation of a tryptic fragment from Clostridium perfringens theta-toxin that contains sites for membrane binding and self-aggregation.
The Journal of biological chemistry 1991;266(19):12449-54.
1991: Harris R W; Sims P J; Tweten R K
Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes.
Infection and immunity 1991;59(7):2499-501.
1991: Harris R W; Sims P J; Tweten R K
Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study.
The Journal of biological chemistry 1991;266(11):6936-41.
1988: Tweten R K
Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin.
Infection and immunity 1988;56(12):3235-40.
1988: Tweten R K
Cloning and expression in Escherichia coli of the perfringolysin O (theta-toxin) gene from Clostridium perfringens and characterization of the gene product.
Infection and immunity 1988;56(12):3228-34.
1988: Meador J; Tweten R K
Purification and characterization of toxin B from Clostridium difficile.
Infection and immunity 1988;56(7):1708-14.

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