Victor Tybulewicz

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Fisher Elizabeth M C; Lana-Elola Eva; Watson Sheona D; Vassiliou George; Tybulewicz Victor L J
New approaches for modelling sporadic genetic disease in the mouse.
Tybulewicz Victor L J; Henderson Robert B
Rho family GTPases and their regulators in lymphocytes.
Robinson Matthew J; Osorio Fabiola; Rosas Marcela; Freitas Rui P; Schweighoffer Edina; Gross Olaf; Verbeek J Sjef; Ruland Jürgen; Tybulewicz Victor; Brown Gordon D; Moita Luis Ferreira; Taylor Philip R; Reis e Sousa Caetano
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.

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All Publications

2009: Fisher Elizabeth M C; Lana-Elola Eva; Watson Sheona D; Vassiliou George; Tybulewicz Victor L J
New approaches for modelling sporadic genetic disease in the mouse.
Disease models & mechanisms 2009;2(9-10):446-53.
2009: Tybulewicz Victor L J; Henderson Robert B
Rho family GTPases and their regulators in lymphocytes.
Nature reviews. Immunology 2009;9(9):630-44.
2009: Robinson Matthew J; Osorio Fabiola; Rosas Marcela; Freitas Rui P; Schweighoffer Edina; Gross Olaf; Verbeek J Sjef; Ruland Jürgen; Tybulewicz Victor; Brown Gordon D; Moita Luis Ferreira; Taylor Philip R; Reis e Sousa Caetano
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
The Journal of experimental medicine 2009;206(9):2037-51.
2009: Gross Olaf; Poeck Hendrik; Bscheider Michael; Dostert Catherine; Hannesschläger Nicole; Endres Stefan; Hartmann Gunther; Tardivel Aubry; Schweighoffer Edina; Tybulewicz Victor; Mocsai Attila; Tschopp Jürg; Ruland Jürgen
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
Nature 2009;459(7245):433-6.
2009: Corbetta Sara; Gualdoni Sara; Ciceri Gabriele; Monari Marta; Zuccaro Emanuela; Tybulewicz Victor L J; de Curtis Ivan
Essential role of Rac1 and Rac3 GTPases in neuronal development.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(5):1347-57.
2009: Wiseman Frances K; Alford Kate A; Tybulewicz Victor L J; Fisher Elizabeth M C
Down syndrome--recent progress and future prospects.
Human molecular genetics 2009;18(R1):R75-83.
2009: Saveliev Alexander; Tybulewicz Victor L J
Lymphocyte signaling: beyond knockouts.
Nature immunology 2009;10(4):361-4.
2009: Galante Micaela; Jani Harsha; Vanes Lesley; Daniel Hervé; Fisher Elizabeth M C; Tybulewicz Victor L J; Bliss Timothy V P; Morice Elise
Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome.
Human molecular genetics 2009;18(8):1449-63.
2009: Dumont Celine; Corsoni-Tadrzak Agnieszka; Ruf Sandra; de Boer Jasper; Williams Adam; Turner Martin; Kioussis Dimitris; Tybulewicz Victor L J
Rac GTPases play critical roles in early T-cell development.
Blood 2009;113(17):3990-8.
2009: David Rachel; Ma Liang; Ivetic Aleksandar; Takesono Aya; Ridley Anne J; Chai Jian-Guo; Tybulewicz Victor L; Marelli-Berg Federica M
T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.
Blood 2009;113(16):3696-705.
2009: Wang Yuqin; Mulligan Claire; Denyer Gareth; Delom Frederic; Dagna-Bricarelli Franca; Tybulewicz Victor L J; Fisher Elizabeth M C; Griffiths William J; Nizetic Dean; Groet Jürgen
Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome.
Molecular & cellular proteomics : MCP 2009;8(4):585-95.
2008: Wilson Michael D; Barbosa-Morais Nuno L; Schmidt Dominic; Conboy Caitlin M; Vanes Lesley; Tybulewicz Victor L J; Fisher Elizabeth M C; Tavaré Simon; Odom Duncan T
Species-specific transcription in mice carrying human chromosome 21.
Science (New York, N.Y.) 2008;322(5900):434-8.
2008: Canzonetta Claudia; Mulligan Claire; Deutsch Samuel; Ruf Sandra; O'Doherty Aideen; Lyle Robert; Borel Christelle; Lin-Marq Nathalie; Delom Frederic; Groet Jürgen; Schnappauf Felix; De Vita Serena; Averill Sharon; Priestley John V; Martin Joanne E; Shipley Janet; Denyer Gareth; Epstein Charles J; Fillat Cristina; Estivill Xavier; Tybulewicz Victor L J; Fisher Elizabeth M C; Antonarakis Stylianos E; Nizetic Dean
DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome.
American journal of human genetics 2008;83(3):388-400.
2008: Rapley Jonathan; Tybulewicz Victor L J; Rittinger Katrin
Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.
EMBO reports 2008;9(7):655-61.
2008: Fallah-Arani Farnaz; Schweighoffer Edina; Vanes Lesley; Tybulewicz Victor L J
Redundant role for Zap70 in B cell development and activation.
European journal of immunology 2008;38(6):1721-33.
2008: Liang Bitao; Workman Craig; Lee Janine; Chew Claude; Dale Benjamin M; Colonna Lucrezia; Flores Marcella; Li Nianyu; Schweighoffer Edina; Greenberg Steven; Tybulewicz Victor; Vignali Dario; Clynes Raphael
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5916-26.
2008: Dennehy Kevin M; Ferwerda Gerben; Faro-Trindade Inês; Pyz Elwira; Willment Janet A; Taylor Philip R; Kerrigan Ann; Tsoni S Vicky; Gordon Siamon; Meyer-Wentrup Friederike; Adema Gosse J; Kullberg Bart-Jan; Schweighoffer Edina; Tybulewicz Victor; Mora-Montes Hector M; Gow Neil A R; Williams David L; Netea Mihai G; Brown Gordon D
Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
European journal of immunology 2008;38(2):500-6.
2008: Arana Eloisa; Vehlow Anne; Harwood Naomi E; Vigorito Elena; Henderson Robert; Turner Martin; Tybulewicz Victor L J; Batista Facundo D
Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.
Immunity 2008;28(1):88-99.
2008: Depoil David; Fleire Sebastian; Treanor Bebhinn L; Weber Michele; Harwood Naomi E; Marchbank Kevin L; Tybulewicz Victor L J; Batista Facundo D
CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.
Nature immunology 2008;9(1):63-72.
2008: Yamanishi Yoshinori; Kitaura Jiro; Izawa Kumi; Matsuoka Takayuki; Oki Toshihiko; Lu Yang; Shibata Fumi; Yamazaki Satoshi; Kumagai Hidetoshi; Nakajima Hideaki; Maeda-Yamamoto Mari; Tybulewicz Victor L J; Takai Toshiyuki; Kitamura Toshio
Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.
Blood 2008;111(2):688-98.
2008: Morice Elise; Andreae Laura C; Cooke Sam F; Vanes Lesley; Fisher Elizabeth M C; Tybulewicz Victor L J; Bliss Timothy V P
Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(7):492-500.
2008: Dumont Celine; Henderson Robert; Tybulewicz Victor L J
Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development.
Methods in enzymology 2008;439():235-54.
2007: Ramaswamy Madhu; Dumont Celine; Cruz Anthony C; Muppidi Jagan R; Gomez Timothy S; Billadeau Daniel D; Tybulewicz Victor L J; Siegel Richard M
Cutting edge: Rac GTPases sensitize activated T cells to die via Fas.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6384-8.
2007: Kissil Joseph L; Walmsley Marita J; Hanlon Linda; Haigis Kevin M; Bender Kim Carla F; Sweet-Cordero Alejandro; Eckman Matthew S; Tuveson David A; Capobianco Anthony J; Tybulewicz Victor L J; Jacks Tyler
Requirement for Rac1 in a K-ras induced lung cancer in the mouse.
Cancer research 2007;67(17):8089-94.
2007: Nodari Alessandro; Zambroni Desirée; Quattrini Angelo; Court Felipe A; D'Urso Alessandra; Recchia Alessandra; Tybulewicz Victor L J; Wrabetz Lawrence; Feltri M Laura
Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination.
The Journal of cell biology 2007;177(6):1063-75.
2007: Slack Emma C; Robinson Matthew J; Hernanz-Falcón Patricia; Brown Gordon D; Williams David L; Schweighoffer Edina; Tybulewicz Victor L; Reis e Sousa Caetano
Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan.
European journal of immunology 2007;37(6):1600-12.
2007: LeibundGut-Landmann Salomé; Gross Olaf; Robinson Matthew J; Osorio Fabiola; Slack Emma C; Tsoni S Vicky; Schweighoffer Edina; Tybulewicz Victor; Brown Gordon D; Ruland Jürgen; Reis e Sousa Caetano
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
Nature immunology 2007;8(6):630-8.
2007: Izawa Kumi; Kitaura Jiro; Yamanishi Yoshinori; Matsuoka Takayuki; Oki Toshihiko; Shibata Fumi; Kumagai Hidetoshi; Nakajima Hideaki; Maeda-Yamamoto Mari; Hauchins Jeffrey P; Tybulewicz Victor L J; Takai Toshiyuki; Kitamura Toshio
Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3.
The Journal of biological chemistry 2007;282(25):17997-8008.
2007: Zou Wei; Kitaura Hideki; Reeve Jennifer; Long Fanxin; Tybulewicz Victor L J; Shattil Sanford J; Ginsberg Mark H; Ross F Patrick; Teitelbaum Steven L
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.
The Journal of cell biology 2007;176(6):877-88.
2007: Hughan Sascha C; Hughes Craig E; McCarty Owen J T; Schweighoffer Edina; Soultanova Izoumroud; Ware Jerry; Tybulewicz Victor L J; Watson Steve P
GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(2):422-9.
2007: Mensah Afua; Mulligan Claire; Linehan Jackie; Ruf Sandra; O'Doherty Aideen; Grygalewicz Beata; Shipley Janet; Groet Juergen; Tybulewicz Victor; Fisher Elizabeth; Brandner Sebastian; Nizetic Dean
An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model.
BMC developmental biology 2007;7():131.
2007: Schymeinsky Jürgen; Then Cornelia; Sindrilaru Anca; Gerstl Ronald; Jakus Zoltán; Tybulewicz Victor L J; Scharffetter-Kochanek Karin; Walzog Barbara
Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes.
PloS one 2007;2(11):e1132.
2006: Tybulewicz Victor L J; Fisher Elizabeth M C
New techniques to understand chromosome dosage: mouse models of aneuploidy.
Human molecular genetics 2006;15 Spec No 2():R103-9.
2006: Sebzda Eric; Hibbard Chris; Sweeney Shawn; Abtahian Farhad; Bezman Natalie; Clemens Gina; Maltzman Jonathan S; Cheng Lan; Liu Feiyan; Turner Martin; Tybulewicz Victor; Koretzky Gary A; Kahn Mark L
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development.
Developmental cell 2006;11(3):349-61.
2006: Robin Catherine; Ottersbach Katrin; Durand Charles; Peeters Marian; Vanes Lesley; Tybulewicz Victor; Dzierzak Elaine
An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells.
Developmental cell 2006;11(2):171-80.
2006: Wheeler Ann P; Wells Claire M; Smith Stephen D; Vega Francisco M; Henderson Robert B; Tybulewicz Victor L; Ridley Anne J
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration.
Journal of cell science 2006;119(Pt 13):2749-57.
2006: Papoutsopoulou Stamatia; Symons Antony; Tharmalingham Tharsana; Belich Monica P; Kaiser Frank; Kioussis Dimitris; O'Garra Anne; Tybulewicz Victor; Ley Steven C
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.
Nature immunology 2006;7(6):606-15.
2006: Suzuki-Inoue Katsue; Fuller Gemma L J; García Angel; Eble Johannes A; Pöhlmann Stefan; Inoue Osamu; Gartner T Kent; Hughan Sascha C; Pearce Andrew C; Laing Gavin D; Theakston R David G; Schweighoffer Edina; Zitzmann Nicole; Morita Takashi; Tybulewicz Victor L J; Ozaki Yukio; Watson Steve P
A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.
Blood 2006;107(2):542-9.
2005: McCarty Owen J T; Larson Mark K; Auger Jocelyn M; Kalia Neena; Atkinson Ben T; Pearce Andrew C; Ruf Sandra; Henderson Robert B; Tybulewicz Victor L J; Machesky Laura M; Watson Steve P
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.
The Journal of biological chemistry 2005;280(47):39474-84.
2005: Wells Claire M; Bhavsar Parag J; Evans Iwan R; Vigorito Elena; Turner Martin; Tybulewicz Victor; Ridley Anne J
Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.
Experimental cell research 2005;310(2):303-10.
2005: O'Doherty Aideen; Ruf Sandra; Mulligan Claire; Hildreth Victoria; Errington Mick L; Cooke Sam; Sesay Abdul; Modino Sonie; Vanes Lesley; Hernandez Diana; Linehan Jacqueline M; Sharpe Paul T; Brandner Sebastian; Bliss Timothy V P; Henderson Deborah J; Nizetic Dean; Tybulewicz Victor L J; Fisher Elizabeth M C
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
Science (New York, N.Y.) 2005;309(5743):2033-7.
2005: Prisco Antonella; Vanes Lesley; Ruf Sandra; Trigueros Cesar; Tybulewicz Victor L J
Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.
Immunity 2005;23(3):263-74.
2005: Tybulewicz Victor L J
Vav-family proteins in T-cell signalling.
Current opinion in immunology 2005;17(3):267-74.
2005: Rogers Neil C; Slack Emma C; Edwards Alexander D; Nolte Martijn A; Schulz Oliver; Schweighoffer Edina; Williams David L; Gordon Siamon; Tybulewicz Victor L; Brown Gordon D; Reis e Sousa Caetano
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.
Immunity 2005;22(4):507-17.
2005: Faccio Roberta; Teitelbaum Steven L; Fujikawa Keiko; Chappel Jean; Zallone Alberta; Tybulewicz Victor L; Ross F Patrick; Swat Wojciech
Vav3 regulates osteoclast function and bone mass.
Nature medicine 2005;11(3):284-90.
2005: Kohno Masayuki; Yamasaki Sho; Tybulewicz Victor L J; Saito Takashi
Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen.
Blood 2005;105(5):2059-65.
2005: Simon Maria; Vanes Lesley; Geahlen Robert L; Tybulewicz Victor L J
Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.
The Journal of biological chemistry 2005;280(6):4510-7.
2004: Herre Jurgen; Marshall Andrew S J; Caron Emmanuelle; Edwards Alexander D; Williams David L; Schweighoffer Edina; Tybulewicz Victor; Reis e Sousa Caetano; Gordon Siamon; Brown Gordon D
Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages.
Blood 2004;104(13):4038-45.
2004: Tybulewicz Victor L J
Commentary: New insights into the complexity of phosphatidylinositol lipid signaling in B lymphocytes.
European journal of immunology 2004;34(11):2964-7.
2004: Benvenuti Federica; Hugues Stephanie; Walmsley Marita; Ruf Sandra; Fetler Luc; Popoff Michel; Tybulewicz Victor L J; Amigorena Sebastian
Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming.
Science (New York, N.Y.) 2004;305(5687):1150-3.
2004: Meade Josephine; Tybulewicz Victor L J; Turner Martin
The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells.
European journal of immunology 2004;34(4):1102-10.
2004: Reynolds Lucinda F; de Bettignies Carine; Norton Trisha; Beeser Alexander; Chernoff Jonathan; Tybulewicz Victor L J
Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.
The Journal of biological chemistry 2004;279(18):18239-46.
2004: Wells Claire M; Walmsley Marita; Ooi Steen; Tybulewicz Victor; Ridley Anne J
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration.
Journal of cell science 2004;117(Pt 7):1259-68.
2004: Faure Sophie; Salazar-Fontana Laura Inés; Semichon Monique; Tybulewicz Victor L J; Bismuth Georges; Trautmann Alain; Germain Ronald N; Delon Jérôme
ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation.
Nature immunology 2004;5(3):272-9.
2003: Walmsley Marita J; Ooi Steen K T; Reynolds Lucinda F; Smith Susan Harless; Ruf Sandra; Mathiot Anne; Vanes Lesley; Williams David A; Cancro Michael P; Tybulewicz Victor L J
Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling.
Science (New York, N.Y.) 2003;302(5644):459-62.
2003: Zompi Simona; Hamerman Jessica A; Ogasawara Kouetsu; Schweighoffer Edina; Tybulewicz Victor L J; Di Santo James P; Lanier Lewis L; Colucci Francesco
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.
Nature immunology 2003;4(6):565-72.
2003: Schweighoffer Edina; Vanes Lesley; Mathiot Anne; Nakamura Tetsuya; Tybulewicz Victor L J
Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.
Immunity 2003;18(4):523-33.
2003: Tybulewicz Victor L J; Ardouin Laurence; Prisco Antonella; Reynolds Lucinda F
Vav1: a key signal transducer downstream of the TCR.
Immunological reviews 2003;192():42-52.
2003: Ardouin Laurence; Bracke Madelon; Mathiot Anne; Pagakis Stamatis N; Norton Trisha; Hogg Nancy; Tybulewicz Victor L J
Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse.
European journal of immunology 2003;33(3):790-7.
2003: Abtahian Farhad; Guerriero Anastasia; Sebzda Eric; Lu Min-Min; Zhou Rong; Mocsai Attila; Myers Erin E; Huang Bin; Jackson David G; Ferrari Victor A; Tybulewicz Victor; Lowell Clifford A; Lepore John J; Koretzky Gary A; Kahn Mark L
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
Science (New York, N.Y.) 2003;299(5604):247-51.
2003: Sedlik Christine; Orbach Daniel; Veron Philippe; Schweighoffer Edina; Colucci Francesco; Gamberale Romina; Ioan-Facsinay Andrea; Verbeek Sjef; Ricciardi-Castagnoli Paola; Bonnerot Christian; Tybulewicz Victor L J; Di Santo James; Amigorena Sebastian
A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):846-52.
2002: Smyth Lesley A; Ardouin Laurence; Williams Owen; Norton Trisha; Tybulewicz Victor; Kioussis Dimitris
Inefficient clustering of tyrosine-phosphorylated proteins at the immunological synapse in response to an antagonist peptide.
European journal of immunology 2002;32(12):3386-94.
2002: Pearce Andrew C; Wilde Jonathan I; Doody Gina M; Best Denise; Inoue Osamu; Vigorito Elena; Tybulewicz Victor L J; Turner Martin; Watson Steve P
Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.
Blood 2002;100(10):3561-9.
2002: Tybulewicz Victor L J
Chemokines and the immunological synapse.
Immunology 2002;106(3):287-8.
2002: Reynolds Lucinda F; Smyth Lesley A; Norton Trisha; Freshney Norman; Downward Julian; Kioussis Dimitris; Tybulewicz Victor L J
Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.
The Journal of experimental medicine 2002;195(9):1103-14.
2002: Mócsai Attila; Zhou Meijuan; Meng Fanying; Tybulewicz Victor L; Lowell Clifford A
Syk is required for integrin signaling in neutrophils.
Immunity 2002;16(4):547-58.
2002: Bassermann Florian; Jahn Thomas; Miething Cornelius; Seipel Petra; Bai Ren-Yuan; Coutinho Sunita; Tybulewicz Victor L; Peschel Christian; Duyster Justus
Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway.
The Journal of biological chemistry 2002;277(14):12437-45.
2002: Colucci Francesco; Schweighoffer Edina; Tomasello Elena; Turner Martin; Ortaldo John R; Vivier Eric; Tybulewicz Victor L J; Di Santo James P
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases.
Nature immunology 2002;3(3):288-94.
2001: Vines C M; Potter J W; Xu Y; Geahlen R L; Costello P S; Tybulewicz V L; Lowell C A; Chang P W; Gresham H D; Willman C L
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.
Immunity 2001;15(4):507-19.
2001: Colucci F; Rosmaraki E; Bregenholt S; Samson S I; Di Bartolo V; Turner M; Vanes L; Tybulewicz V; Di Santo J P
Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms.
The Journal of experimental medicine 2001;193(12):1413-24.
2001: Manetz T S; Gonzalez-Espinosa C; Arudchandran R; Xirasagar S; Tybulewicz V; Rivera J
Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.
Molecular and cellular biology 2001;21(11):3763-74.
2000: Lach-Trifilieff E; Menear K; Schweighoffer E; Tybulewicz V L; Walker C
Syk-deficient eosinophils show normal interleukin-5-mediated differentiation, maturation, and survival but no longer respond to FcgammaR activation.
Blood 2000;96(7):2506-10.
2000: Asazuma N; Wilde J I; Berlanga O; Leduc M; Leo A; Schweighoffer E; Tybulewicz V; Bon C; Liu S K; McGlade C J; Schraven B; Watson S P
Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.
The Journal of biological chemistry 2000;275(43):33427-34.
2000: Basson M A; Wilson T J; Legname G A; Sarner N; Tomlinson P D; Tybulewicz V L; Zamoyska R
Early growth response (Egr)-1 gene induction in the thymus in response to TCR ligation during early steps in positive selection is not required for CD8 lineage commitment.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2444-50.
2000: Colucci F; Guy-Grand D; Wilson A; Turner M; Schweighoffer E; Tybulewicz V L; Di Santo J P
A new look at Syk in alpha beta and gamma delta T cell development using chimeric mice with a low competitive hematopoietic environment.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5140-5.
2000: Turner M; Schweighoffer E; Colucci F; Di Santo J P; Tybulewicz V L
Tyrosine kinase SYK: essential functions for immunoreceptor signalling.
Immunology today 2000;21(3):148-54.
1999: Pasquet J M; Gross B; Quek L; Asazuma N; Zhang W; Sommers C L; Schweighoffer E; Tybulewicz V; Judd B; Lee J R; Koretzky G; Love P E; Samelson L E; Watson S P
LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.
Molecular and cellular biology 1999;19(12):8326-34.
1999: Mee P J; Turner M; Basson M A; Costello P S; Zamoyska R; Tybulewicz V L
Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice.
European journal of immunology 1999;29(9):2923-33.
1999: Colucci F; Turner M; Schweighoffer E; Guy-Grand D; Di Bartolo V; Salcedo M; Tybulewicz V L; Di Santo J P
Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1769-74.
1999: Briddon S J; Melford S K; Turner M; Tybulewicz V; Watson S P
Collagen mediates changes in intracellular calcium in primary mouse megakaryocytes through syk-dependent and -independent pathways.
Blood 1999;93(11):3847-55.
1999: Hernandez D; Mee P J; Martin J E; Tybulewicz V L; Fisher E M
Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21.
Human molecular genetics 1999;8(5):923-33.
1999: Costello P S; Walters A E; Mee P J; Turner M; Reynolds L F; Prisco A; Sarner N; Zamoyska R; Tybulewicz V L
The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3035-40.
1999: Colucci F; Soudais C; Rosmaraki E; Vanes L; Tybulewicz V L; Di Santo J P
Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2761-5.
1999: Gulbranson-Judge A; Tybulewicz V L; Walters A E; Toellner K M; MacLennan I C; Turner M
Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help.
European journal of immunology 1999;29(2):477-87.
1999: Gross B S; Lee J R; Clements J L; Turner M; Tybulewicz V L; Findell P R; Koretzky G A; Watson S P
Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets.
The Journal of biological chemistry 1999;274(9):5963-71.
1998: Basson M A; Bommhardt U; Mee P J; Tybulewicz V L; Zamoyska R
Molecular requirements for lineage commitment in the thymus--antibody-mediated receptor engagements reveal a central role for lck in lineage decisions.
Immunological reviews 1998;165():181-94.
1998: Hostert A; Garefalaki A; Mavria G; Tolaini M; Roderick K; Norton T; Mee P J; Tybulewicz V L; Coles M; Kioussis D
Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.
Immunity 1998;9(4):497-508.
1998: Tybulewicz V L
Analysis of antigen receptor signalling using mouse gene targeting.
Current opinion in cell biology 1998;10(2):195-204.
1998: Malbec O; Fong D C; Turner M; Tybulewicz V L; Cambier J C; Fridman W H; Daëron M
Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1647-58.
1997: Connor F; Bertwistle D; Mee P J; Ross G M; Swift S; Grigorieva E; Tybulewicz V L; Ashworth A
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation.
Nature genetics 1997;17(4):423-30.
1997: Turner M; Gulbranson-Judge A; Quinn M E; Walters A E; MacLennan I C; Tybulewicz V L
Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool.
The Journal of experimental medicine 1997;186(12):2013-21.
1997: Turner M; Mee P J; Walters A E; Quinn M E; Mellor A L; Zamoyska R; Tybulewicz V L
A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes.
Immunity 1997;7(4):451-60.
1997: Melford S K; Turner M; Briddon S J; Tybulewicz V L; Watson S P
Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide.
The Journal of biological chemistry 1997;272(44):27539-42.
1997: Crowley M T; Costello P S; Fitzer-Attas C J; Turner M; Meng F; Lowell C; Tybulewicz V L; DeFranco A L
A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.
The Journal of experimental medicine 1997;186(7):1027-39.
1997: Poole A; Gibbins J M; Turner M; van Vugt M J; van de Winkel J G; Saito T; Tybulewicz V L; Watson S P
The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.
The EMBO journal 1997;16(9):2333-41.
1996: Costello P S; Turner M; Walters A E; Cunningham C N; Bauer P H; Downward J; Tybulewicz V L
Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.
Oncogene 1996;13(12):2595-605.
1996: Nishinakamura R; Miyajima A; Mee P J; Tybulewicz V L; Murray R
Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions.
Blood 1996;88(7):2458-64.
1995: Turner M; Mee P J; Costello P S; Williams O; Price A A; Duddy L P; Furlong M T; Geahlen R L; Tybulewicz V L
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.
Nature 1995;378(6554):298-302.
1995: Hernandez D; Pannett A A; Tybulewicz V; Fisher E M
Highly polymorphic sequence at D21S1448 mapping close to D21S55, within the Down syndrome critical region.
Human genetics 1995;95(6):721-2.
1995: Tarakhovsky A; Turner M; Schaal S; Mee P J; Duddy L P; Rajewsky K; Tybulewicz V L
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.
Nature 1995;374(6521):467-70.

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