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Lynda Tyrrell

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Mark Estacion; Zhimiao Lin; Lynda Tyrrell; Yong Yang; Yang Yang; Sulayman D Dib-Hajj; Stephen G Waxman
A new Nav1.7 mutation in an erythromelalgia patient.
Shannon D Shields; Lynda Tyrrell; Pamela J Zwinger; Joel A Black; Xiaoyang Cheng; Sulayman D Dib-Hajj; Emmanuella M Eastman; Andreas Gasser; Masashi Iwata; Carl Y Saab; Stephen G Waxman
A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis.
Yang Yang; Jian Zhang; Yang Zhang; Sulayman D Dib-Hajj; Mark Estacion; Lynda Tyrrell; Stephen G Waxman
Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

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All Publications

2013: Mark Estacion; Zhimiao Lin; Lynda Tyrrell; Yong Yang; Yang Yang; Sulayman D Dib-Hajj; Stephen G Waxman
A new Nav1.7 mutation in an erythromelalgia patient.
Biochemical and biophysical research communications 2013;432(1):99-104.
2012: Shannon D Shields; Lynda Tyrrell; Pamela J Zwinger; Joel A Black; Xiaoyang Cheng; Sulayman D Dib-Hajj; Emmanuella M Eastman; Andreas Gasser; Masashi Iwata; Carl Y Saab; Stephen G Waxman
A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis.
Annals of neurology 2012;71(2):186-94.
2012: Yang Yang; Jian Zhang; Yang Zhang; Sulayman D Dib-Hajj; Mark Estacion; Lynda Tyrrell; Stephen G Waxman
Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.
Nature communications 2012;3():1186.
2011: Hye-Sook Ahn; Joel A Black; Peng Zhao; Lynda Tyrrell; Stephen G Waxman; Sulayman D Dib-Hajj
Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons.
Molecular pain 2011;7():32.
2010: Hye-Sook Ahn; Sulayman D Dib-Hajj; James Cox; Lynda Tyrrell; Frances V Elmslie; Antonia A Clarke; Joost P H Drenth; C Geoffrey Woods; Stephen G Waxman
A new Nav1.7 sodium channel mutation I234T in a child with severe pain.
European journal of pain (London, England) 2010;14(9):944-50.
2010: Severine Stamboulian; Jin-Sung Choi; Hye-Sook Ahn; Yu-Wen Chang; Lynda Tyrrell; Joel A Black; Stephen G Waxman; Sulayman D Dib-Hajj
ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(5):1637-47.
2010: Xiaoyang Cheng; Sulayman D Dib-Hajj; Lynda Tyrrell; Dowain A Wright; Tanya Z Fischer; Stephen G Waxman
Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders.
Molecular pain 2010;6():24.
2009: Angelika Lampert; Sulayman D Dib-Hajj; Emmanuella M Eastman; Lynda Tyrrell; Zhimiao Lin; Yong Yang; Stephen G Waxman
Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials.
Biochemical and biophysical research communications 2009;390(2):319-24.
2009: Mark Estacion; T Patrick Harty; Jin-Sung Choi; Lynda Tyrrell; Sulayman D Dib-Hajj; Stephen G Waxman
A sodium channel gene SCN9A polymorphism that increases nociceptor excitability.
Annals of neurology 2009;66(6):862-6.
2009: Chongyang Han; Sulayman D Dib-Hajj; Zhimiao Lin; Yan Li; Emmanuella M Eastman; Lynda Tyrrell; Xianwei Cao; Yong Yang; Stephen G Waxman
Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation.
Brain : a journal of neurology 2009;132(Pt 7):1711-22.
2009: Jin-Sung Choi; Lili Zhang; Sulayman D Dib-Hajj; Chongyang Han; Lynda Tyrrell; Zhimiao Lin; Xiaoliang Wang; Yong Yang; Stephen G Waxman
Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.
Experimental neurology 2009;216(2):383-9.
2009: Sulayman D Dib-Hajj; Jin-Sung Choi; Lawrence J Macala; Lynda Tyrrell; Joel A Black; Theodore R Cummins; Stephen G Waxman
Transfection of rat or mouse neurons by biolistics or electroporation.
Nature protocols 2009;4(8):1118-26.
2008: Angelika Lampert; Andrias O O'Reilly; Sulayman D Dib-Hajj; Lynda Tyrrell; Bonnie A Wallace; Stephen G Waxman
A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation.
The Journal of biological chemistry 2008;283(35):24118-27.
2008: Andy Hudmon; Jin-Sung Choi; Lynda Tyrrell; Joel A Black; Anthony M Rush; Stephen G Waxman; Sulayman D Dib-Hajj
Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(12):3190-201.
2008: Sulayman D Dib-Hajj; Mark Estacion; brian jarecki; Lynda Tyrrell; Tanya Z Fischer; Mark Lawden; Theodore R Cummins; Stephen G Waxman
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable.
Molecular pain 2008;4():37.
2008: Xiaoyang Cheng; Sulayman D Dib-Hajj; Lynda Tyrrell; Stephen G Waxman
Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade.
Molecular pain 2008;4():1.
2006: T Patrick Harty; Sulayman D Dib-Hajj; Lynda Tyrrell; Rachael Blackman; Fuki M Hisama; John B Rose; Stephen G Waxman
Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(48):12566-75.
2006: Angelika Lampert; Sulayman D Dib-Hajj; Lynda Tyrrell; Stephen G Waxman
Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating.
The Journal of biological chemistry 2006;281(47):36029-35.
2006: Anthony M Rush; Ellen K Wittmack; Lynda Tyrrell; J Black; Sulayman D Dib-Hajj; Stephen G Waxman
Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily.
The European journal of neuroscience 2006;23(10):2551-62.
2006: Chongyang Han; Anthony M Rush; Sulayman D Dib-Hajj; Song Li; Zhe Xu; Yun Wang; Lynda Tyrrell; Xiaoliang Wang; Yong Yang; Stephen G Waxman
Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7.
Annals of neurology 2006;59(3):553-8.
2005: Sulayman D Dib-Hajj; A M Rush; Theodore R Cummins; Fuki M Hisama; Steven P Novella; Lynda Tyrrell; L Marshall; Stephen G Waxman
Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons.
Brain : a journal of neurology 2005;128(Pt 8):1847-54.
2005: Chuanju Liu; Theodore R Cummins; Lynda Tyrrell; J Black; Stephen G Waxman; Sulayman D Dib-Hajj
CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Na(v)1.8.
Molecular and cellular neurosciences 2005;28(4):636-49.
2004: Bhaval S Shah; Anthony M Rush; Shujun Liu; Lynda Tyrrell; J Black; Sulayman D Dib-Hajj; Stephen G Waxman
Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(33):7387-99.
2004: Jin-Sung Choi; Lynda Tyrrell; Stephen G Waxman; Sulayman D Dib-Hajj
Functional role of the C-terminus of voltage-gated sodium channel Na(v)1.8.
FEBS letters 2004;572(1-3):256-60.
2002: Sulayman D Dib-Hajj; Lynda Tyrrell; Stephen G Waxman
Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution.
Molecular neurobiology 2002;26(2-3):235-50.
2001: Lynda Tyrrell; Muthukrishnan Renganathan; Sulayman D Dib-Hajj; Stephen G Waxman
Glycosylation alters steady-state inactivation of sodium channel Nav1.9/NaN in dorsal root ganglion neurons and is developmentally regulated.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(24):9629-37.
2000: A A Sleeper; Theodore R Cummins; Sulayman D Dib-Hajj; William N Hormuzdiar; Lynda Tyrrell; Stephen G Waxman; J Black
Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(19):7279-89.
2000: J Fjell; Peter Hjelmstrom; William N Hormuzdiar; M Milenkovic; Fabio Aglieco; Lynda Tyrrell; Sulayman D Dib-Hajj; Stephen G Waxman; J Black
Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors.
Neuroreport 2000;11(1):199-202.
1999: Sulayman D Dib-Hajj; Lynda Tyrrell; Theodore R Cummins; J Black; Patrick M Wood; Stephen G Waxman
Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons.
FEBS letters 1999;462(1-2):117-20.
1999: Sulayman D Dib-Hajj; Lynda Tyrrell; Andrew Escayg; Patrick M Wood; Miriam H Meisler; Stephen G Waxman
Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN.
Genomics 1999;59(3):309-18.
1999: B Jack Longley; Dean D Metcalfe; Michael D Tharp; Xiuhua Wang; Lynda Tyrrell; S Z Lu; D Heitjan; Yongsheng Ma
Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1609-14.
1998: Sulayman D Dib-Hajj; Lynda Tyrrell; J Black; Stephen G Waxman
NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8963-8.
1998: Takahiro Kunisada; S Z Lu; H Yoshida; Shin-Ichi Nishikawa; S Nishikawa; M Mizoguchi; Shin-Ichi Hayashi; Lynda Tyrrell; D A Williams; X Wang; B Jack Longley
Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor.
The Journal of experimental medicine 1998;187(10):1565-73.
1997: B Jack Longley; Lynda Tyrrell; Y Ma; D A Williams; Ruth Halaban; K Langley; H S Lu; N M Schechter
Chymase cleavage of stem cell factor yields a bioactive, soluble product.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9017-21.
1997: B Jack Longley; Lynda Tyrrell; S Lu; Y Ma; V Klump; George F Murphy
Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.
The Journal of investigative dermatology 1997;108(5):792-6.
1996: A B West; G N Soloway; G Lizarraga; Lynda Tyrrell; J B Longley
Type 73 human papillomavirus in esophageal squamous cell carcinoma: a novel association.
Cancer 1996;77(12):2440-4.
1996: B Jack Longley; Lynda Tyrrell; S Z Lu; Y S Ma; K Langley; T G Ding; T Duffy; P Jacobs; Laura H Tang; I Modlin
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm.
Nature genetics 1996;12(3):312-4.
1995: Lynda Tyrrell; J Elias; J Longley
Detection of specific mRNAs in routinely processed dermatopathology specimens.
The American Journal of dermatopathology 1995;17(5):476-83.
1995: J Longley; Lynda Tyrrell; S Z Lu; J Farrell; T G Ding; S Yan; D Sallee; Peter Heald; C Berger; R Tigelaar
Malignant and normal T cells show random use of T-cell receptor alpha chain variable regions in patients with cutaneous T-cell lymphoma.
The Journal of investigative dermatology 1995;105(1):62-4.
1993: Ruth Halaban; Lynda Tyrrell; J Longley; Y Yarden; J Rubin
Pigmentation and proliferation of human melanocytes and the effects of melanocyte-stimulating hormone and ultraviolet B light.
Annals of the New York Academy of Sciences 1993;680():290-301.
1993: B Jack Longley; G S Morganroth; Lynda Tyrrell; T G Ding; D M Anderson; D E Williams; Ruth Halaban
Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis.
The New England journal of medicine 1993;328(18):1302-7.