Silvio Aime

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Gianolio Eliana; Napolitano Roberta; Fedeli Franco; Arena Francesca; Aime Silvio
Poly-beta-cyclodextrin based platform for pH mapping via a ratiometric 19F/1H MRI method.
Werner Eric J; Botta Mauro; Aime Silvio; Raymond Kenneth N
Effect of a mesitylene-based ligand cap on the relaxometric properties of Gd(III) hydroxypyridonate MRI contrast agents.
Terreno Enzo; Stancanello Joseph; Longo Dario; Castelli Daniela Delli; Milone Luciano; Sanders Honorius M H F; Kok Maarten B; Uggeri Fulvio; Aime Silvio
Methods for an improved detection of the MRI-CEST effect.

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All Publications

2009: Gianolio Eliana; Napolitano Roberta; Fedeli Franco; Arena Francesca; Aime Silvio
Poly-beta-cyclodextrin based platform for pH mapping via a ratiometric 19F/1H MRI method.
Chemical communications (Cambridge, England) 2009;(40):6044-6.
2009: Werner Eric J; Botta Mauro; Aime Silvio; Raymond Kenneth N
Effect of a mesitylene-based ligand cap on the relaxometric properties of Gd(III) hydroxypyridonate MRI contrast agents.
Contrast media & molecular imaging 2009;4(5):220-9.
2009: Terreno Enzo; Stancanello Joseph; Longo Dario; Castelli Daniela Delli; Milone Luciano; Sanders Honorius M H F; Kok Maarten B; Uggeri Fulvio; Aime Silvio
Methods for an improved detection of the MRI-CEST effect.
Contrast media & molecular imaging 2009;4(5):237-47.
2009: Reineri Francesca; Santelia Daniela; Gobetto Roberto; Aime Silvio
Effect of low and zero magnetic field on the hyperpolarization lifetime in parahydrogenated perdeuterated molecules.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2009;200(1):15-20.
2009: Siega Patrizia; Wuerges Jochen; Arena Francesca; Gianolio Eliana; Fedosov Sergey N; Dreos Renata; Geremia Silvano; Aime Silvio; Randaccio Lucio
Release of toxic Gd3+ ions to tumour cells by vitamin B12 bioconjugates.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(32):7980-9.
2009: Crivello Antonella; Nervi Carlo; Gobetto Roberto; Crich Simonetta Geninatti; Szabo Iboya; Barge Alessandro; Toppino Antonio; Deagostino Annamaria; Venturello Paolo; Aime Silvio
Towards improved boron neutron capture therapy agents: evaluation of in vitro cellular uptake of a glutamine-functionalized carborane.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(6):883-90.
2009: Aime Silvio; Castelli Daniela Delli; Crich Simonetta Geninatti; Gianolio Eliana; Terreno Enzo
Pushing the sensitivity envelope of lanthanide-based magnetic resonance imaging (MRI) contrast agents for molecular imaging applications.
Accounts of chemical research 2009;42(7):822-31.
2009: Meade Thomas J; Aime Silvio
Chemistry of molecular imaging.
Accounts of chemical research 2009;42(7):821.
2009: Baroni Simona; Pariani Giorgio; Fanali Gabriella; Longo Dario; Ascenzi Paolo; Aime Silvio; Fasano Mauro
Thermodynamic analysis of hydration in human serum heme-albumin.
Biochemical and biophysical research communications 2009;385(3):385-9.
2009: Que Emily L; Gianolio Eliana; Baker Suzanne L; Wong Audrey P; Aime Silvio; Chang Christopher J
Copper-responsive magnetic resonance imaging contrast agents.
Journal of the American Chemical Society 2009;131(24):8527-36.
2009: Briley-Saebo Karen C; Geninatti-Crich Simonetta; Cormode David P; Barazza Alessandra; Mulder Willem J M; Chen Wei; Giovenzana Giovanni B; Fisher Edward A; Aime Silvio; Fayad Zahi A
High-relaxivity gadolinium-modified high-density lipoproteins as magnetic resonance imaging contrast agents.
The journal of physical chemistry. B 2009;113(18):6283-9.
2009: Baroni Simona; Consonni Roberto; Ferrante Gianni; Aime Silvio
Relaxometric studies for food characterization: the case of balsamic and traditional balsamic vinegars.
Journal of agricultural and food chemistry 2009;57(8):3028-32.
2009: Cagnolini Aldo; D'Amelio Nicola; Metcalfe Edmund; Nguyen Hanh D; Aime Silvio; Swenson Rolf E; Linder Karen E
Isolation of a 177Hf complex formed by beta-decay of a 177Lu-labeled radiotherapeutic compound and NMR structural elucidation of the ligand and its Lu and Hf complexes.
Inorganic chemistry 2009;48(7):3114-24.
2009: Elemento Elisa M; Parker David; Aime Silvio; Gianolio Eliana; Lattuada Luciano
Variation of water exchange dynamics with ligand structure and stereochemistry in lanthanide complexes based on 1,4-diazepine derivatives.
Organic & biomolecular chemistry 2009;7(6):1120-31.
2009: Digilio Giuseppe; Catanzaro Valeria; Fedeli Franco; Gianolio Eliana; Menchise Valeria; Napolitano Roberta; Gringeri Concetta; Aime Silvio
Targeting exofacial protein thiols with Gd(III) complexes. An efficient procedure for MRI cell labelling.
Chemical communications (Cambridge, England) 2009;(8):893-5.
2009: Aime Silvio; Gianolio Eliana; Arena Francesca; Barge Alessandro; Martina Katia; Heropoulos George; Cravotto Giancarlo
New cyclodextrin dimers and trimers capable of forming supramolecular adducts with shape-specific ligands.
Organic & biomolecular chemistry 2009;7(2):370-9.
2009: Vucic Esad; Sanders Honorius M H F; Arena Francesca; Terreno Enzo; Aime Silvio; Nicolay Klaas; Leupold Eik; Dathe Margitta; Sommerdijk Nico A J M; Fayad Zahi A; Mulder Willem J M
Well-defined, multifunctional nanostructures of a paramagnetic lipid and a lipopeptide for macrophage imaging.
Journal of the American Chemical Society 2009;131(2):406-7.
2009: Werner Eric J; Kozhukh Julia; Botta Mauro; Moore Evan G; Avedano Stefano; Aime Silvio; Raymond Kenneth N
1,2-hydroxypyridonate/terephthalamide complexes of gadolinium(III): synthesis, stability, relaxivity, and water exchange properties.
Inorganic chemistry 2009;48(1):277-86.
2009: Aime Silvio; Castelli Daniela Delli; Terreno Enzo
Chapter 10 - Lanthanide-loaded paramagnetic liposomes as switchable magnetically oriented nanovesicles.
Methods in enzymology 2009;464():193-210.
2009: Baranyai Zsolt; Uggeri Fulvio; Giovenzana Giovanni B; Bényei Attila; Brücher Erno; Aime Silvio
Equilibrium and kinetic properties of the lanthanoids(III) and various divalent metal complexes of the heptadentate ligand AAZTA.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(7):1696-705.
2009: Terreno Enzo; Delli Castelli Daniela; Violante Elisabetta; Sanders Honorius M H F; Sommerdijk Nico A J M; Aime Silvio
Osmotically shrunken LIPOCEST agents: an innovative class of magnetic resonance imaging contrast media based on chemical exchange saturation transfer.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(6):1440-8.
2009: Stefania Rachele; Tei Lorenzo; Barge Alessandro; Geninatti Crich Simonetta; Szabo Ibolya; Cabella Claudia; Cravotto Giancarlo; Aime Silvio
Tuning glutamine binding modes in Gd-DOTA-based probes for an improved MRI visualization of tumor cells.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(1):76-85.
2008: Arrais Aldo; Botta Mauro; Avedano Stefano; Giovenzana Giovanni Battista; Gianolio Eliana; Boccaleri Enrico; Stanghellini Pier Luigi; Aime Silvio
Carbon coated microshells containing nanosized Gd(III) oxidic phases for multiple bio-medical applications.
Chemical communications (Cambridge, England) 2008;(45):5936-8.
2008: Aime Silvio; Barge Alessandro; Crivello Antonella; Deagostino Annamaria; Gobetto Roberto; Nervi Carlo; Prandi Cristina; Toppino Antonio; Venturello Paolo
Synthesis of Gd(III)-C-palmitamidomethyl-C'-DOTAMA-C(6)-o-carborane: a new dual agent for innovative MRI/BNCT applications.
Organic & biomolecular chemistry 2008;6(23):4460-6.
2008: Tomaselli Simona; Zanzoni Serena; Ragona Laura; Gianolio Eliana; Aime Silvio; Assfalg Michael; Molinari Henriette
Solution structure of the supramolecular adduct between a liver cytosolic bile acid binding protein and a bile acid-based gadolinium(III)-chelate, a potential hepatospecific magnetic resonance imaging contrast agent.
Journal of medicinal chemistry 2008;51(21):6782-92.
2008: Reineri Francesca; Viale Alessandra; Giovenzana Giovanbattista; Santelia Daniela; Dastrù Walter; Gobetto Roberto; Aime Silvio
New hyperpolarized contrast agents for 13C-MRI from para-hydrogenation of oligooxyethylenic alkynes.
Journal of the American Chemical Society 2008;130(45):15047-53.
2008: Terreno Enzo; Delli Castelli Daniela; Cabella Claudia; Dastrù Walter; Sanino Alberto; Stancanello Joseph; Tei Lorenzo; Aime Silvio
Paramagnetic liposomes as innovative contrast agents for magnetic resonance (MR) molecular imaging applications.
Chemistry & biodiversity 2008;5(10):1901-12.
2008: Tei Lorenzo; Baranyai Zsolt; Botta Mauro; Piscopo Laura; Aime Silvio; Giovenzana Giovanni B
Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives.
Organic & biomolecular chemistry 2008;6(13):2361-8.
2008: Canavese Caterina; Mereu M Cristina; Aime Silvio; Lazzarich Elisa; Fenoglio Roberta; Quaglia Marco; Stratta Piero
Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness.
Journal of nephrology 2008;21(3):324-36.
2008: Kálmán Ferenc K; Baranyai Zsolt; Tóth Imre; Bányai István; Király Róbert; Brücher Ernö; Aime Silvio; Sun Xiankai; Sherry A Dean; Kovács Zoltán
Synthesis, potentiometric, kinetic, and NMR Studies of 1,4,7,10-tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) ions.
Inorganic chemistry 2008;47(9):3851-62.
2008: Terreno Enzo; Sanino Alberto; Carrera Carla; Castelli Daniela Delli; Giovenzana Giovanni B; Lombardi Alberto; Mazzon Roberta; Milone Luciano; Visigalli Massimo; Aime Silvio
Determination of water permeability of paramagnetic liposomes of interest in MRI field.
Journal of inorganic biochemistry 2008;102(5-6):1112-9.
2008: Ghiani Simona; Baroni Simona; Burgio Daniela; Digilio Giuseppe; Fukuhara Masaki; Martino Paola; Monda Keiji; Nervi Carlo; Kiyomine Akira; Aime Silvio
Characterization of human hair melanin and its degradation products by means of magnetic resonance techniques.
Magnetic resonance in chemistry : MRC 2008;46(5):471-9.
2008: Ramponi Simona; Rebaudengo Cristina; Cabella Claudia; Grotti Adriana; Vultaggio Stefania; Aime Silvio; Morisetti Alberto; Lorusso Vito
Contrast-enhanced MRI of murine sponge model for progressive angiogenesis assessed with gadoteridol (ProHance) and gadocoletic acid trisodium salt (B22956/1).
Journal of magnetic resonance imaging : JMRI 2008;27(4):872-80.
2008: Barge Alessandro; Tei Lorenzo; Upadhyaya Dharita; Fedeli Franco; Beltrami Lorena; Stefanìa Rachele; Aime Silvio; Cravotto Giancarlo
Bifunctional ligands based on the DOTA-monoamide cage.
Organic & biomolecular chemistry 2008;6(7):1176-84.
2008: Delli Castelli Daniela; Terreno Enzo; Carrera Carla; Giovenzana Giovanni B; Mazzon Roberta; Rollet Simona; Visigalli Massimo; Aime Silvio
Lanthanide-loaded paramagnetic liposomes as switchable magnetically oriented nanovesicles.
Inorganic chemistry 2008;47(8):2928-30.
2008: Datta Ankona; Hooker Jacob M; Botta Mauro; Francis Matthew B; Aime Silvio; Raymond Kenneth N
High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents.
Journal of the American Chemical Society 2008;130(8):2546-52.
2008: Terreno Enzo; Barge Alessandro; Beltrami Lorena; Cravotto Giancarlo; Castelli Daniela Delli; Fedeli Franco; Jebasingh Bhagavathsingh; Aime Silvio
Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents.
Chemical communications (Cambridge, England) 2008;(5):600-2.
2008: Terreno Enzo; Castelli Daniela Delli; Milone Luciano; Rollet Simona; Stancanello Joseph; Violante Elisabetta; Aime Silvio
First ex-vivo MRI co-localization of two LIPOCEST agents.
Contrast media & molecular imaging 2008;3(1):38-43.
2008: Gianolio Eliana; Giovenzana Giovanni Battista; Ciampa Anna; Lanzardo Stefania; Imperio Daniela; Aime Silvio
A novel method of cellular labeling: anchoring mr-imaging reporter particles on the outer cell surface.
ChemMedChem 2008;3(1):60-2.
2008: Tei Lorenzo; Botta Mauro; Lovazzano Clara; Barge Alessandro; Milone Luciano; Aime Silvio
1H and 17O NMR relaxometric study in aqueous solution of Gd(III) complexes of EGTA-like derivatives bearing methylenephosphonic groups.
Magnetic resonance in chemistry : MRC 2008;46 Suppl 1():S86-93.
2008: Aime Silvio; Dastrù Walter; Gobetto Roberto; Santelia Daniela; Viale Alessandra
Agents for polarization enhancement in MRI.
Handbook of experimental pharmacology 2008;(185 Pt 1):247-72.
2008: Battistini Elisa; Gianolio Eliana; Gref Ruxandra; Couvreur Patrick; Fuzerova Silvia; Othman Mohammad; Aime Silvio; Badet Bernard; Durand Philippe
High-relaxivity magnetic resonance imaging (MRI) contrast agent based on supramolecular assembly between a gadolinium chelate, a modified dextran, and poly-beta-cyclodextrin.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(15):4551-61.
2007: Crich Simonetta Geninatti; Lanzardo Stefania; Alberti Diego; Belfiore Simona; Ciampa Anna; Giovenzana Giovanni B; Lovazzano Clara; Pagliarin Roberto; Aime Silvio
Magnetic resonance imaging detection of tumor cells by targeting low-density lipoprotein receptors with Gd-loaded low-density lipoprotein particles.
Neoplasia (New York, N.Y.) 2007;9(12):1046-56.
2007: Avedano Stefano; Tei Lorenzo; Lombardi Alberto; Giovenzana Giovanni B; Aime Silvio; Longo Dario; Botta Mauro
Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange.
Chemical communications (Cambridge, England) 2007;(45):4726-8.
2007: Carrera Carla; Digilio Giuseppe; Baroni Simona; Burgio Daniela; Consol Simona; Fedeli Franco; Longo Dario; Mortillaro Armando; Aime Silvio
Synthesis and characterization of a Gd(III) based contrast agent responsive to thiol containing compounds.
Dalton transactions (Cambridge, England : 2003) 2007;(43):4980-7.
2007: Assfalg Michael; Gianolio Eliana; Zanzoni Serena; Tomaselli Simona; Russo Vito Lo; Cabella Claudia; Ragona Laura; Aime Silvio; Molinari Henriette
NMR structural studies of the supramolecular adducts between a liver cytosolic bile acid binding protein and gadolinium(III)-chelates bearing bile acids residues: molecular determinants of the binding of a hepatospecific magnetic resonance imaging contrast agent.
Journal of medicinal chemistry 2007;50(22):5257-68.
2007: Jocher Christoph J; Moore Evan G; Xu Jide; Avedano Stefano; Botta Mauro; Aime Silvio; Raymond Kenneth N
1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO.
Inorganic chemistry 2007;46(22):9182-91.
2007: Bussolati Benedetta; Grange Cristina; Tei Lorenzo; Deregibus Maria Chiara; Ercolani Mauro; Aime Silvio; Camussi Giovanni
Targeting of human renal tumor-derived endothelial cells with peptides obtained by phage display.
Journal of molecular medicine (Berlin, Germany) 2007;85(8):897-906.
2007: Battistini Elisa; Mortillaro Armando; Aime Silvio; Peters Joop A
Molecular recognition of sugars by lanthanide (III) complexes of a conjugate of N, N-bis[2-[bis[2-(1, 1-dimethylethoxy)-2-oxoethyl]amino]ethyl]glycine and phenylboronic acid.
Contrast media & molecular imaging 2007;2(4):163-71.
2007: Jocher Christoph J; Botta Mauro; Avedano Stefano; Moore Evan G; Xu Jide; Aime Silvio; Raymond Kenneth N
Optimized relaxivity and stability of [Gd(H(2,2)-1,2-HOPO)(H2O)]- for use as an MRI contrast agent.
Inorganic chemistry 2007;46(12):4796-8.
2007: Tesauro Diego; Accardo Antonella; Gianolio Eliana; Paduano Luigi; Teixeira José; Schillén Karin; Aime Silvio; Morelli Giancarlo
Peptide derivatized lamellar aggregates as target-specific MRI contrast agents.
Chembiochem : a European journal of chemical biology 2007;8(8):950-5.
2007: Baranyai Zsolt; Gianolio Eliana; Ramalingam Kondareddiar; Swenson Rolf; Ranganathan Ramachandran; Brücher E; Aime Silvio
The effects of intramolecular H-bond formation on the stability constant and water exchange rate of the Gd(III)-diethylenetriamine-N'-(3-amino-1,1-propylenephosphonic)-N, N,N'',N''-tetraacetate complex.
Contrast media & molecular imaging 2007;2(2):94-102.
2007: Aime Silvio; Delli Castelli Daniela; Lawson Dale; Terreno Enzo
Gd-loaded liposomes as T1, susceptibility, and CEST agents, all in one.
Journal of the American Chemical Society 2007;129(9):2430-1.
2007: Rodríguez Elisenda; Simoes Rui V; Roig Anna; Molins Elies; Nedelko Nataliya; Slawska-Waniewska Anna; Aime Silvio; Arús Carles; Cabañas Miquel E; Sanfeliu Coral; Cerdán Sebastián; García-Martín Maria Luisa
An iron-based T1 contrast agent made of iron-phosphate complexes: in vitro and in vivo studies.
Magma (New York, N.Y.) 2007;20(1):27-37.
2007: Werner Eric J; Avedano Stefano; Botta Mauro; Hay Benjamin P; Moore Evan G; Aime Silvio; Raymond Kenneth N
Highly soluble tris-hydroxypyridonate Gd(III) complexes with increased hydration number, fast water exchange, slow electronic relaxation, and high relaxivity.
Journal of the American Chemical Society 2007;129(7):1870-1.
2007: Accardo Antonella; Tesauro Diego; Morelli Giancarlo; Gianolio Eliana; Aime Silvio; Vaccaro Mauro; Mangiapia Gaetano; Paduano Luigi; Schillén Karin
High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(2):267-76.
2007: Biancone Luigi; Crich Simonetta Geninatti; Cantaluppi Vincenzo; Romanazzi Giuseppe Mauriello; Russo Simona; Scalabrino Elisa; Esposito Giovanna; Figliolini Federico; Beltramo Silvia; Perin Paolo Cavallo; Segoloni Giuseppe Paolo; Aime Silvio; Camussi Giovanni
Magnetic resonance imaging of gadolinium-labeled pancreatic islets for experimental transplantation.
NMR in biomedicine 2007;20(1):40-8.
2007: Gianolio Eliana; Giovenzana Giovanni B; Longo Dario; Longo Irene; Menegotto Ivan; Aime Silvio
Relaxometric and modelling studies of the binding of a lipophilic Gd-AAZTA complex to fatted and defatted human serum albumin.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(20):5785-97.
2007: Terreno Enzo; Cabella Claudia; Carrera Carla; Delli Castelli Daniela; Mazzon Roberta; Rollet Simona; Stancanello Joseph; Visigalli Massimo; Aime Silvio
From spherical to osmotically shrunken paramagnetic liposomes: an improved generation of LIPOCEST MRI agents with highly shifted water protons.
Angewandte Chemie (International ed. in English) 2007;46(6):966-8.
2006: Thompson Amber L; Parker David; Fulton David A; Howard Judith A K; Pandya Shashi U; Puschmann Horst; Senanayake Kanthi; Stenson Philip A; Badari Alessandra; Botta Mauro; Avedano Stefano; Aime Silvio
On the role of the counter-ion in defining water structure and dynamics: order, structure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes.
Dalton transactions (Cambridge, England : 2003) 2006;(47):5605-16.
2006: Bruno Erik; Digilio Giuseppe; Cabella Claudia; de Reggi Andrea; Baroni Simona; Mainero Valentina; Aime Silvio
Water exchange across the erythrocyte plasma membrane studied by HR-MAS NMR spectroscopy.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;56(5):978-85.
2006: Pierre Valérie C; Botta Mauro; Aime Silvio; Raymond Kenneth N
Substituent effects on Gd(III)-based MRI contrast agents: optimizing the stability and selectivity of the complex and the number of coordinated water molecules.
Inorganic chemistry 2006;45(20):8355-64.
2006: Benedetto Sabrina; Pulito Roberta; Crich Simonetta Geninatti; Tarone Guido; Aime Silvio; Silengo Lorenzo; Hamm Jörg
Quantification of the expression level of integrin receptor alpha(v)beta3 in cell lines and MR imaging with antibody-coated iron oxide particles.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;56(4):711-6.
2006: Geninatti Crich Simonetta; Bussolati Benedetta; Tei Lorenzo; Grange Cristina; Esposito Giovanna; Lanzardo Stefania; Camussi Giovanni; Aime Silvio
Magnetic resonance visualization of tumor angiogenesis by targeting neural cell adhesion molecules with the highly sensitive gadolinium-loaded apoferritin probe.
Cancer research 2006;66(18):9196-201.
2006: Aime Silvio; Fedeli Franco; Sanino Alberto; Terreno Enzo
A R2/R1 ratiometric procedure for a concentration-independent, pH-responsive, Gd(III)-based MRI agent.
Journal of the American Chemical Society 2006;128(35):11326-7.
2006: Geninatti Crich Simonetta; Cabella Claudia; Barge Alessandro; Belfiore Simona; Ghirelli Cristina; Lattuada Luciano; Lanzardo Stefania; Mortillaro Armando; Tei Lorenzo; Visigalli Massimo; Forni Guido; Aime Silvio
In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes.
Journal of medicinal chemistry 2006;49(16):4926-36.
2006: Lattuada Luciano; Demattio Silvia; Vincenzi Veronica; Cabella Claudia; Visigalli Massimo; Aime Silvio; Crich Simonetta Geninatti; Gianolio Eliana
Magnetic resonance imaging of tumor cells by targeting the amino acid transport system.
Bioorganic & medicinal chemistry letters 2006;16(15):4111-4.
2006: Pierre Valérie C; Botta Mauro; Aime Silvio; Raymond Kenneth N
Fe(III)-templated Gd(III) self-assemblies-a new route toward macromolecular MRI contrast agents.
Journal of the American Chemical Society 2006;128(29):9272-3.
2006: Rudovský Jakub; Botta Mauro; Hermann Petr; Hardcastle Kenneth I; Lukes Ivan; Aime Silvio
PAMAM dendrimeric conjugates with a Gd-DOTA phosphinate derivative and their adducts with polyaminoacids: the interplay of global motion, internal rotation, and fast water exchange.
Bioconjugate chemistry 2006;17(4):975-87.
2006: Terreno Enzo; Botta Mauro; Dastrù Walter; Aime Silvio
Gd-enhanced MR images of substrates other than water.
Contrast media & molecular imaging 2006;1(3):101-5.
2006: Rudovský Jakub; Botta Mauro; Hermann Petr; Koridze Avtandil; Aime Silvio
Relaxometric and solution NMR structural studies on ditopic lanthanide(III) complexes of a phosphinate analogue of DOTA with a fast rate of water exchange.
Dalton transactions (Cambridge, England : 2003) 2006;(19):2323-33.
2006: Aime Silvio; Gianolio Eliana; Uggeri Fulvio; Tagliapietra Silvia; Barge Alessandro; Cravotto Giancarlo
New paramagnetic supramolecular adducts for MRI applications based on non-covalent interactions between Gd(III)-complexes and beta- or gamma-cyclodextrin units anchored to chitosan.
Journal of inorganic biochemistry 2006;100(5-6):931-8.
2006: Pierre Valérie C; Botta Mauro; Aime Silvio; Raymond Kenneth N
Tuning the coordination number of hydroxypyridonate-based gadolinium complexes: implications for MRI contrast agents.
Journal of the American Chemical Society 2006;128(16):5344-5.
2006: Bussolati Benedetta; Grange Cristina; Bruno Stefania; Buttiglieri Stefano; Deregibus Maria Chiara; Tei Lorenzo; Aime Silvio; Camussi Giovanni
Neural-cell adhesion molecule (NCAM) expression by immature and tumor-derived endothelial cells favors cell organization into capillary-like structures.
Experimental cell research 2006;312(6):913-24.
2006: Aime Silvio; Gianolio Eliana; Palmisano Giovanni; Robaldo Bruna; Barge Alessandro; Boffa Luisa; Cravotto Giancarlo
Improved syntheses of bis(beta-cyclodextrin) derivatives, new carriers for gadolinium complexes.
Organic & biomolecular chemistry 2006;4(6):1124-30.
2006: Fulton David A; Elemento Elisa M; Aime Silvio; Chaabane Linda; Botta Mauro; Parker David
Glycoconjugates of gadolinium complexes for MRI applications.
Chemical communications (Cambridge, England) 2006;(10):1064-6.
2006: Terreno Enzo; Geninatti Crich Simonetta; Belfiore Simona; Biancone Luigi; Cabella Claudia; Esposito Giovanna; Manazza Andrea D; Aime Silvio
Effect of the intracellular localization of a Gd-based imaging probe on the relaxation enhancement of water protons.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;55(3):491-7.
2006: Aime Silvio; Gobetto Roberto; Reineri Francesca; Canet Daniel
Polarization transfer from para-hydrogen to heteronuclei: effect of H/D substitution. The case of AA'X and A2A2'X spin systems.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;178(2):184-92.
2006: Cabella C; Crich S Geninatti; Corpillo D; Barge A; Ghirelli C; Bruno E; Lorusso V; Uggeri F; Aime S
Cellular labeling with Gd(III) chelates: only high thermodynamic stabilities prevent the cells acting as 'sponges' of Gd3+ ions.
Contrast media & molecular imaging 2006;1(1):23-9.
2006: Vasalatiy Olga; Zhao Piyu; Zhang Shanrong; Aime Silvio; Sherry A Dean
Catalytic effects of apoferritin interior surface residues on water proton exchange in lanthanide complexes.
Contrast media & molecular imaging 2006;1(1):10-4.
2005: Aime Silvio; Bruno Erik; Cabella Claudia; Colombatto Sebastiano; Digilio Giuseppe; Mainero Valentina
HR-MAS of cells: A "cellular water shift" due to water-protein interactions?
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;54(6):1547-52.
2005: Aime Silvio; Dastrù Walter; Gobetto Roberto; Viale Alessandra
para-Hydrogenation of unsaturated moieties on poly(lysine) derived substrates for the development of novel hyperpolarized MRI contrast agents.
Organic & biomolecular chemistry 2005;3(21):3948-54.
2005: Terreno Enzo; Botta Mauro; Boniforte Patrizia; Bracco Chiara; Milone Luciano; Mondino Bruna; Uggeri Fulvio; Aime Silvio
A multinuclear NMR relaxometry study of ternary adducts formed between heptadentate Gd(III) chelates and L-lactate.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(19):5531-7.
2005: Aime Silvio; Delli Castelli Daniela; Terreno Enzo
Highly sensitive MRI chemical exchange saturation transfer agents using liposomes.
Angewandte Chemie (International ed. in English) 2005;44(34):5513-5.
2005: Rudovsky Jakub; Hermann Petr; Botta Mauro; Aime Silvio; Lukes Ivan
Dendrimeric Gd(III) complex of a monophosphinated DOTA analogue: optimizing relaxivity by reducing internal motion.
Chemical communications (Cambridge, England) 2005;(18):2390-2.
2005: Aime Silvio; Gianolio Eliana; Longo Dario; Pagliarin Roberto; Lovazzano Clara; Sisti Massimo
New insights for pursuing high relaxivity MRI agents from modelling the binding interaction of Gd(III) chelates to HSA.
Chembiochem : a European journal of chemical biology 2005;6(5):818-20.
2005: Aime Silvio; Calabi Luisella; Biondi Luca; De Miranda Mario; Ghelli Stefano; Paleari Lino; Rebaudengo Cristina; Terreno Enzo
Iopamidol: Exploring the potential use of a well-established x-ray contrast agent for MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;53(4):830-4.
2005: Aime Silvio; Carrera Carla; Delli Castelli Daniela; Geninatti Crich Simonetta; Terreno Enzo
Tunable imaging of cells labeled with MRI-PARACEST agents.
Angewandte Chemie (International ed. in English) 2005;44(12):1813-5.
2005: Crich Simonetta Geninatti; Lanzardo Stefania; Barge Alessandro; Esposito Giovanna; Tei Lorenzo; Forni Guido; Aime Silvio
Visualization through magnetic resonance imaging of DNA internalized following "in vivo" electroporation.
Molecular imaging : official journal of the Society for Molecular Imaging 2005;4(1):7-17.
2005: Fulton David A; O'Halloran Mark; Parker David; Senanayake Kanthi; Botta Mauro; Aime Silvio
Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates.
Chemical communications (Cambridge, England) 2005;(4):474-6.
2005: Geninatti Crich Simonetta; Barge Alessandro; Battistini Elisa; Cabella Claudia; Coluccia Sara; Longo Dario; Mainero Valentina; Tarone Guido; Aime Silvio
Magnetic resonance imaging visualization of targeted cells by the internalization of supramolecular adducts formed between avidin and biotinylated Gd3+ chelates.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(1):78-86.
2005: Rudovský Jakub; Kotek Jan; Hermann Petr; Lukes Ivan; Mainero Valentina; Aime Silvio
Synthesis of a bifunctional monophosphinic acid DOTA analogue ligand and its lanthanide(III) complexes. A gadolinium(III) complex endowed with an optimal water exchange rate for MRI applications.
Organic & biomolecular chemistry 2005;3(1):112-7.
2005: Canavese Caterina; Mereu Cristina; Nordio Maurizio; Sabbioni Enrico; Aime Silvio
Blast from the past: the aluminum's ghost on the lanthanum salts.
Current medicinal chemistry 2005;12(14):1631-6.
2005: Aime S; Barge A; Gianolio E; Pagliarin R; Silengo L; Tei L
High relaxivity contrast agents for MRI and molecular imaging.
Ernst Schering Research Foundation workshop 2005;(49):99-121.
2004: Thompson Marlon K; Doble Dan M J; Tso Luke S; Barra Serena; Botta Mauro; Aime Silvio; Raymond Kenneth N
Hetero-tripodal hydroxypyridonate gadolinium complexes: syntheses, relaxometric properties, water exchange dynamics, and human serum albumin binding.
Inorganic chemistry 2004;43(26):8577-86.
2004: Aime S; Barge A; Cabella C; Crich S Geninatti; Gianolio E
Targeting cells with MR imaging probes based on paramagnetic Gd(III) chelates.
Current pharmaceutical biotechnology 2004;5(6):509-18.
2004: Aime Silvio; Calabi Luisella; Cavallotti Camilla; Gianolio Eliana; Giovenzana Giovanni B; Losi Pietro; Maiocchi Alessandro; Palmisano Giovanni; Sisti Massimo
[Gd-AAZTA]-: a new structural entry for an improved generation of MRI contrast agents.
Inorganic chemistry 2004;43(24):7588-90.
2004: Corpillo Davide; Cabella Claudia; Geninatti Crich Simonetta; Barge Alessandro; Aime Silvio
Detection and quantification of lanthanide complexes in cell lysates by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Analytical chemistry 2004;76(20):6012-6.
2004: Frullano Luca; Rohovec Jan; Aime Silvio; Maschmeyer Thomas; Prata M Isabel; de Lima J J Pedroso; Geraldes Carlos F G C; Peters Joop A
Towards targeted MRI: new MRI contrast agents for sialic acid detection.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(20):5205-17.
2004: Crich Simonetta Geninatti; Biancone Luigi; Cantaluppi Vincenzo; Duò Debora; Esposito G; Russo Simona; Camussi Giovanni; Aime Silvio
Improved route for the visualization of stem cells labeled with a Gd-/Eu-chelate as dual (MRI and fluorescence) agent.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(5):938-44.
2004: Aime Silvio; Cavallotti Camilla; Gianolio Eliana; Giovenzana Giovanni B; Palmisano Giovanni; Sisti Massimo
Mannich reaction as a new route to pyridine-based polyaminocarboxylic ligands.
Organic letters 2004;6(8):1201-4.
2004: Terreno Enzo; Castelli Daniela Delli; Cravotto Giancarlo; Milone Luciano; Aime Silvio
Ln(III)-DOTAMGly complexes: a versatile series to assess the determinants of the efficacy of paramagnetic chemical exchange saturation transfer agents for magnetic resonance imaging applications.
Investigative radiology 2004;39(4):235-43.
2004: Corpillo Davide; Gardini Giulia; Vaira Anna Maria; Basso Manuela; Aime Silvio; Accotto Gian Paolo; Fasano Mauro
Proteomics as a tool to improve investigation of substantial equivalence in genetically modified organisms: the case of a virus-resistant tomato.
Proteomics 2004;4(1):193-200.
2003: Canavese Caterina; Mereu Cristina; Nordio Maurizio; Sabbioni Enrico; Aime Silvio;
Where have all the lanthanum salts gone, long time passing?
Kidney international 2003;64(6):2327-8; author reply 2328.
2003: Thompson Marlon K; Botta Mauro; Nicolle Gaëlle; Helm Lothar; Aime Silvio; Merbach André E; Raymond Kenneth N
A highly stable gadolinium complex with a fast, associative mechanism of water exchange.
Journal of the American Chemical Society 2003;125(47):14274-5.
2003: Aime Silvio; Delli Castelli Daniela; Terreno Enzo
Supramolecular adducts between poly-L-arginine and [TmIIIdotp]: a route to sensitivity-enhanced magnetic resonance imaging-chemical exchange saturation transfer agents.
Angewandte Chemie (International ed. in English) 2003;42(37):4527-9.
2003: Terreno Enzo; Botta Mauro; Fedeli Franco; Mondino Bruna; Milone Luciano; Aime Silvio
Enantioselective recognition between chiral alpha-hydroxy-carboxylates and macrocyclic heptadentate lanthanide(III) chelates.
Inorganic chemistry 2003;42(16):4891-7.
2003: Aime Silvio; Digilio Giuseppe; Bruno Erik; Mainero Valentina; Baroni Simona; Fasano Mauro
Modulation of the antioxidant activity of HO* scavengers by albumin binding: a 19F-NMR study.
Biochemical and biophysical research communications 2003;307(4):962-6.
2003: Rohovec Jan; Maschmeyer Thomas; Aime Silvio; Peters Joop A
The structure of the sugar residue in glycated human serum albumin and its molecular recognition by phenylboronate.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(10):2193-9.
2003: Botta Mauro; Aime Silvio; Barge Alessandro; Bobba Gabriella; Dickins Rachel S; Parker David; Terreno Enzo
Ternary complexes between cationic GdIII chelates and anionic metabolites in aqueous solution: an NMR relaxometric study.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(9):2102-9.
2003: Fasano Mauro; Baroni Simona; Aime Silvio; Mattu Marco; Ascenzi Paolo
Determination of ferric heme-human serum albumin by 1H NMR relaxometry.
Journal of inorganic biochemistry 2003;95(1):64-7.
2003: O'Sullivan Brendon; Doble Dan M J; Thompson Marlon K; Siering Carsten; Xu Jide; Botta Mauro; Aime Silvio; Raymond Kenneth N
The effect of ligand scaffold size on the stability of tripodal hydroxypyridonate gadolinium complexes.
Inorganic chemistry 2003;42(8):2577-83.
2003: Digilio Giuseppe; Barbero Luca; Bracco Chiara; Corpillo Davide; Esposito Pierandrea; Piquet Gilles; Traversa Silvio; Aime Silvio
NMR structure of two novel polyethylene glycol conjugates of the human growth hormone-releasing factor, hGRF(1-29)-NH2.
Journal of the American Chemical Society 2003;125(12):3458-70.
2003: Peira Elena; Marzola Pasquina; Podio Valerio; Aime Silvio; Sbarbati Andrea; Gasco Maria Rosa
In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide.
Journal of drug targeting 2003;11(1):19-24.
2003: Benetollo F; Bombieri G; Calabi L; Aime S; Botta M
Structural variations across the lanthanide series of macrocyclic DOTA complexes: insights into the design of contrast agents for magnetic resonance imaging.
Inorganic chemistry 2003;42(1):148-57.
2003: Aime Silvio; Barge Alessandro; Botta Mauro; Terreno Enzo
Interactions of lanthanides and their complexes with proteins. Conclusions regarding magnetic resonance imaging.
Metal ions in biological systems 2003;40():643-82.
2002: Aime Silvio; Delli Castelli Daniela; Terreno Enzo
Novel pH-reporter MRI contrast agents.
Angewandte Chemie (International ed. in English) 2002;41(22):4334-6.
2002: Dickins Rachel S; Aime Silvio; Batsanov Andrei S; Beeby Andrew; Botta Mauro; Bruce James I; Howard Judith A K; Love Christine S; Parker David; Peacock Robert D; Puschmann Horst
Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes.
Journal of the American Chemical Society 2002;124(43):12697-705.
2002: Aime Silvio; Cabella Claudia; Colombatto Sebastiano; Geninatti Crich Simonetta; Gianolio Eliana; Maggioni Fabio
Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations.
Journal of magnetic resonance imaging : JMRI 2002;16(4):394-406.
2002: Monzani Enrico; Curto Maria; Galliano Monica; Minchiotti Lorenzo; Aime Silvio; Baroni Simona; Fasano Mauro; Amoresano Angela; Salzano Anna Maria; Pucci Piero; Casella Luigi
Binding and relaxometric properties of heme complexes with cyanogen bromide fragments of human serum albumin.
Biophysical journal 2002;83(4):2248-58.
2002: Bottamauro Mauro; Casellato Umberto; Scalco Cristina; Tamburini Sergio; Tomasin Patrizi; Vigato Pietro A; Aime Silvio; Barge Alessandro
Heterodinuclear Ln[bond]Na complexes with an asymmetrical macrocyclic compartmental Schiff base.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(17):3917-26.
2002: Aime Silvio; Delli Castelli Daniela; Fedeli Franco; Terreno Enzo
A paramagnetic MRI-CEST agent responsive to lactate concentration.
Journal of the American Chemical Society 2002;124(32):9364-5.
2002: Aime Silvio; D'Amelio Nicola; Fragai Marco; Lee Yong-Min; Luchinat Claudio; Terreno Enzo; Valensin Gianni
A paramagnetic probe to localize residues next to carboxylates on protein surfaces.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(6):617-22.
2002: Aime Silvio; Barge Alessandro; Batsanov Andrei S; Botta Mauro; Castelli Daniela Delli; Fedeli Franco; Mortillaro Armando; Parker David; Puschmann Horst
Controlling the variation of axial water exchange rates in macrocyclic lanthanide(III) complexes.
Chemical communications (Cambridge, England) 2002;(10):1120-1.
2002: Aime Silvio; Barge Alessandro; Delli Castelli Daniela; Fedeli Franco; Mortillaro Armando; Nielsen Flemming U; Terreno Enzo
Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2002;47(4):639-48.
2002: Digilio Giuseppe; Bracco Chiara; Barbero Luca; Chicco Daniela; Del Curto Maria D; Esposito Pierandrea; Traversa Silvio; Aime Silvio
NMR conformational analysis of antide, a potent antagonist of the gonadotropin releasing hormone.
Journal of the American Chemical Society 2002;124(13):3431-42.
2002: Aime Silvio; Frullano Luca; Geninatti Crich Simonetta
Compartmentalization of a gadolinium complex in the apoferritin cavity: a route to obtain high relaxivity contrast agents for magnetic resonance imaging.
Angewandte Chemie (International ed. in English) 2002;41(6):1017-9.
2002: Yerly Fabrice; Hardcastle Kenneth I; Helm Lothar; Aime Silvio; Botta Mauro; Merbach André E
Molecular dynamics simulation of [Gd(egta)(H(2)O)](-) in aqueous solution: internal motions of the poly(amino carboxylate) and water ligands, and rotational correlation times.
Chemistry (Weinheim an der Bergstrasse, Germany) 2002;8(5):1031-9.
2002: Aime Silvio; Anelli Lucio; Botta Mauro; Brocchetta Marino; Canton Simonetta; Fedeli Franco; Gianolio Eliana; Terreno Enzo
Relaxometric evaluation of novel manganese(II) complexes for application as contrast agents in magnetic resonance imaging.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(1-2):58-67.
2002: Aime Silvio; Botta Mauro; Mainero Valentina; Terreno Enzo
Separation of intra- and extracellular lactate NMR signals using a lanthanide shift reagent.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2002;47(1):10-3.
2002: Aime Silvio; Dastrù Walter; Crich Simonetta Geninatti; Gianolio Eliana; Mainero Valentina
Innovative magnetic resonance imaging diagnostic agents based on paramagnetic Gd(III) complexes.
Biopolymers 2002;66(6):419-28.
2001: Aime S; Botta I M; Fedeli F; Gianolio E; Terreno E; Anelli P
High-Relaxivity contrast agents for magnetic resonance imaging based on multisite interactions between a beta-cyclodextrin oligomer and suitably functionalized GdIII chelates.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(24):5261-9.
2001: Sunderland C J; Botta M; Aime S; Raymond K N
6-carboxamido-5,4-hydroxypyrimidinones: a new class of heterocyclic ligands and their evaluation as gadolinium chelating agents.
Inorganic chemistry 2001;40(26):6746-56.
2001: Baroni S; Mattu M; Vannini A; Cipollone R; Aime S; Ascenzi P; Fasano M
Effect of ibuprofen and warfarin on the allosteric properties of haem-human serum albumin. A spectroscopic study.
European journal of biochemistry / FEBS 2001;268(23):6214-20.
2001: Doble D M; Botta M; Wang J; Aime S; Barge A; Raymond K N
Optimization of the relaxivity of MRI contrast agents: effect of poly(ethylene glycol) chains on the water-exchange rates of Gd(III) complexes.
Journal of the American Chemical Society 2001;123(43):10758-9.
2001: Lowe M P; Parker D; Reany O; Aime S; Botta M; Castellano G; Gianolio E; Pagliarin R
pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation.
Journal of the American Chemical Society 2001;123(31):7601-9.
2001: Fasano M; Baroni S; Vannini A; Ascenzi P; Aime S
Relaxometric characterization of human hemalbumin.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(5-6):650-8.
2001: Zhang S; Kovacs Z; Burgess S; Aime S; Terreno E; Sherry A D
[DOTA-bis(amide)]lanthanide complexes: NMR evidence for differences in water-molecule exchange rates for coordination isomers.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(1):288-96.
2000: Cohen S M; Xu J; Radkov E; Raymond K N; Botta M; Barge A; Aime S
Syntheses and relaxation properties of mixed gadolinium hydroxypyridinonate MRI contrast agents.
Inorganic chemistry 2000;39(25):5747-56.
2000: Aime S; Botta M; Frullano L; Geninatti Crich S; Giovenzana G; Pagliarin R; Palmisano G; Sirtori F R; Sisti M
[GdPCP2A(H(2)O)(2)](-): a paramagnetic contrast agent designed for improved applications in magnetic resonance imaging.
Journal of medicinal chemistry 2000;43(21):4017-24.
2000: Lopiano L; Fasano M; Giraudo S; Digilio G; Koenig S H; Torre E; Bergamasco B; Aime S
Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation.
Neurochemistry international 2000;37(4):331-6.
2000: Aime S; Bergamasco B; Casu M; Digilio G; Fasano M; Giraudo S; Lopiano L
Isolation and 13C-NMR characterization of an insoluble proteinaceous fraction from substantia nigra of patients with Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(5):977-81.
2000: Aime S; Gianolio E; Terreno E; Giovenzana G B; Pagliarin R; Sisti M; Palmisano G; Botta M; Lowe M P; Parker D
Ternary Gd(III)L-HSA adducts: evidence for the replacement of inner-sphere water molecules by coordinating groups of the protein. Implications for the design of contrast agents for MRI.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(4):488-97.
2000: Aime S; Botta M; Garino E; Crich S G; Giovenzana G; Pagliarin R; Palmisano G; Sisti M
Non-covalent conjugates between cationic polyamino acids and GdIII chelates: a route for seeking accumulation of MRI-contrast agents at tumor targeting sites.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(14):2609-17.
1999: Aime S; Chiaussa M; Digilio G; Gianolio E; Terreno E
Contrast agents for magnetic resonance angiographic applications: 1H and 17O NMR relaxometric investigations on two gadolinium(III) DTPA-like chelates endowed with high binding affinity to human serum albumin.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(6):766-74.
1999: Aime S; Calzoni S; Digilio G; Giraudo S; Fasano M; Maffeo D
A novel 19F-NMR method for the investigation of the antioxidant capacity of biomolecules and biofluids.
Free radical biology & medicine 1999;27(3-4):356-63.
1999: Aime S; Digilio G; Fasano M; Paoletti S; Arnelli A; Ascenzi P
Metal complexes as allosteric effectors of human hemoglobin: an NMR study of the interaction of the gadolinium(III) bis(m-boroxyphenylamide)diethylenetriaminepentaacetic acid complex with human oxygenated and deoxygenated hemoglobin.
Biophysical journal 1999;76(5):2735-43.
1999: Aime S; Botta M; Geninatti Crich S; Giovenzana G; Palmisano G; Sisti M
Novel paramagnetic macromolecular complexes derived from the linkage of a macrocyclic Gd(III) complex to polyamino acids through a squaric acid moiety.
Bioconjugate chemistry 1999;10(2):192-9.
1998: Aime S; Fasano M; Paoletti S; Bellelli A; Coletta M; Ascenzi P
Stabilization of the T-state of ferrous human adult and fetal hemoglobin by Ln(III) complexes: a thermodynamic study.
Journal of inorganic biochemistry 1998;71(1-2):37-43.
1998: Aime S; Bettinelli M; Ferrari M; Razzano E; Terreno E
NMR and luminescence studies on the formation of ternary adducts between HSA and Ln(III)-malonate complexes.
Biochimica et biophysica acta 1998;1385(1):7-16.
1998: Morel S; Terreno E; Ugazio E; Aime S; Gasco M R
NMR relaxometric investigations of solid lipid nanoparticles (SLN) containing gadolinium(III) complexes.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 1998;45(2):157-63.
1997: Aime S; Bergamasco B; Biglino D; Digilio G; Fasano M; Giamello E; Lopiano L
EPR investigations of the iron domain in neuromelanin.
Biochimica et biophysica acta 1997;1361(1):49-58.
1996: Aime S; Fasano M; Paoletti S; Viola F; Tarricone C; Ascenzi P
1H-NMR relaxometric study of pancreatic serine (pro)enzyme inhibition by a Gd(III) chelate bearing boronic functionalities.
Biochemistry and molecular biology international 1996;39(4):741-6.
1996: Aime S; Botta M; Fasano M; Terreno E; Kinchesh P; Calabi L; Paleari L
A new ytterbium chelate as contrast agent in chemical shift imaging and temperature sensitive probe for MR spectroscopy.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1996;35(5):648-51.
1996: Viola F; Aime S; Coletta M; Desideri A; Fasano M; Paoletti S; Tarricone C; Ascenzi P
Azide, cyanide, fluoride, imidazole and pyridine binding to ferric and ferrous native horse heart cytochrome c and to its carboxymethylated derivative: a comparative study.
Journal of inorganic biochemistry 1996;62(3):213-22.
1996: Aime S; Fasano M; Paoletti S; Cutruzzolà F; Desideri A; Bolognesi M; Rizzi M; Ascenzi P
Structural determinants of fluoride and formate binding to hemoglobin and myoglobin: crystallographic and 1H-NMR relaxometric study.
Biophysical journal 1996;70(1):482-8.
1996: Aime S; Fasano M; Bergamasco B; Lopiano L; Quattrocolo G
Nuclear magnetic resonance spectroscopy characterization and iron content determination of human mesencephalic neuromelanin.
Advances in neurology 1996;69():263-70.
1995: Aime S; Fasano M; Paoletti S; Arnelli A; Ascenzi P
NMR relaxometric investigation on human methemoglobin and fluoromethemoglobin. An improved quantitative in vitro assay of human methemoglobin.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1995;33(6):827-31.
1994: Aime S; Fasano M; Bergamasco B; Lopiano L; Valente G
Evidence for a glycidic-lipidic matrix in human neuromelanin, potentially responsible for the enhanced iron sequestering ability of substantia nigra.
Journal of neurochemistry 1994;62(1):369-71.
1993: Aime S; Botta M; Terreno E; Anelli P L; Uggeri F
Gd(DOTP)5-outer-sphere relaxation enhancement promoted by nitrogen bases.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1993;30(5):583-91.
1992: Aime S; Dastrú W; Fasano M; Arnelli A; Castagnola M; Giardina B; Ascenzi P
Quantitative determination of methemoglobin by measuring the solvent-water proton-nuclear magnetic resonance relaxation rate.
Clinical chemistry 1992;38(12):2401-4.
1992: Aime S; Botta M; Ermondi G; Fasano M; Terreno E
Paramagnetic water proton relaxation enhancement: from contrast agents in MRI to reagents for quantitative "in vitro" assays.
Magnetic resonance imaging 1992;10(5):849-54.
1991: Aime S; Fasano M; Terreno E; Groombridge C J
NMR studies of melanins: characterization of a soluble melanin free acid from Sepia ink.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1991;4(5-6):216-21.
1991: Aime S; Fasano M; Terreno E; Sarzanini C; Mentasti E
An NMR study of the interaction between melanin free acid and Mn2+ ions as a model to mimic the enhanced proton relaxation rates in melanotic melanoma.
Magnetic resonance imaging 1991;9(6):963-8.
1989: Aime S; Botta M; Camurati I
NMR studies of L-dopa melanin-manganese(II) complex in water solution.
Journal of inorganic biochemistry 1989;36(1):1-9.
1988: Aime S; Nano R; Grandi M
A new class of contrast agents for magnetic resonance imaging based on selective reduction of water-T2 by chemical exchange.
Investigative radiology 1988;23 Suppl 1():S267-70.
1988: Aime S; Nano R
Factors determining the proton T1 relaxivity in solutions containing Gd-DTPA.
Investigative radiology 1988;23 Suppl 1():S264-6.
1988: Aime S; Crippa P R
13C solid-state cross polarization/magic-angle-spinning nuclear magnetic resonance spectra of natural and synthetic melanins.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1988;1(5):355-7.

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