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Fatih Uckun

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Living Beings

Disorders

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Anatomy

Cultured Tumor Cells

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Co-Publications
Name
68
Venkatachalam, Taracad
58
D'Cruz, Osmond
50
Myers, DE
39
Gaynon, Paul
35
Chelstrom, LM
35
Sather, Harland
33
Waurzyniak, Barbara
31
Qazi, Sanjive
29
Vassilev, Alexei
27
Sensel, Martha
27
Steinherz, Peter
24
Tibbles, Heather
24
Waddick, KG
23
Nachman, James
21
Reaman, Gregory

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Publications

TOP 3
Trigg Michael E; Sather Harland N; Reaman Gregory H; Tubergen David G; Steinherz Peter G; Gaynon Paul S; Uckun Fatih M; Hammond G Denman;
Ten-year survival of children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
D'Cruz Osmond J; Uckun Fatih M
Evaluation of local tolerance of the antiretroviral spermicide (WHI-07)-loaded gel-microemulsion in the porcine female reproductive tract.
Uckun Fatih M; Tibbles Heather; Ozer Zahide; Qazi Sanjive; Vassilev Alexei
Anti-inflammatory activity profile of JANEX-1 in preclinical animal models.

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All Publications

2008: Trigg Michael E; Sather Harland N; Reaman Gregory H; Tubergen David G; Steinherz Peter G; Gaynon Paul S; Uckun Fatih M; Hammond G Denman;
Ten-year survival of children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Leukemia & lymphoma 2008;49(6):1142-54.
2008: D'Cruz Osmond J; Uckun Fatih M
Evaluation of local tolerance of the antiretroviral spermicide (WHI-07)-loaded gel-microemulsion in the porcine female reproductive tract.
Journal of applied toxicology : JAT 2008;28(3):303-14.
2008: Uckun Fatih M; Tibbles Heather; Ozer Zahide; Qazi Sanjive; Vassilev Alexei
Anti-inflammatory activity profile of JANEX-1 in preclinical animal models.
Bioorganic & medicinal chemistry 2008;16(3):1287-98.
2008: Uckun Fatih M
Clinical potential of targeting Bruton's tyrosine kinase.
International reviews of immunology 2008;27(1-2):43-69.
2007: Uckun Fatih M
Chemosensitizing anti-cancer activity of LFM-A13, a leflunomide metabolite analog targeting polo-like kinases.
Cell cycle (Georgetown, Tex.) 2007;6(24):3021-6.
2007: Uckun Fatih M; Tibbles Heather E; Vassilev Alexei O
Bruton's tyrosine kinase as a new therapeutic target.
Anti-cancer agents in medicinal chemistry 2007;7(6):624-32.
2007: Uckun Fatih M; Vassilev Alexei; Dibirdik Ilker; Tibbles Heather
Targeting JAK3 tyrosine kinase-linked signal transduction pathways with rationally-designed inhibitors.
Anti-cancer agents in medicinal chemistry 2007;7(6):612-23.
2007: Uckun Fatih M; Vassilev A; Tibbles H
Non-receptor tyrosine kinases as molecular targets for patient tailored cancer therapy.
Anti-cancer agents in medicinal chemistry 2007;7(6):593.
2007: D'Cruz Osmond J; Uckun Fatih M
Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1.
Fertility and sterility 2007;88(4 Suppl):1197-206.
2007: D'Cruz Osmond J; Uckun Fatih M
Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1.
American journal of reproductive immunology (New York, N.Y. : 1989) 2007;58(2):75-97.
2007: D'Cruz Osmond J; Uckun Fatih M
Limitations of the human-PBL-SCID mouse model for vaginal transmission of HIV-1.
American journal of reproductive immunology (New York, N.Y. : 1989) 2007;57(5):353-60.
2007: Uckun Fatih M; Dibirdik Ilker; Qazi Sanjive; Vassilev Alexei; Ma Hong; Mao Chen; Benyumov Alexey; Emami Katayoon H
Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).
Bioorganic & medicinal chemistry 2007;15(2):800-14.
2007: D'Cruz Osmond J; Uckun Fatih M
Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat.
Toxicologic pathology 2007;35(7):910-27.
2007: Uckun Fatih M; Tibbles Heather E; Venkatachalam Taracad K; Erbeck Douglas
In vivo pharmacokinetics, metabolism, toxicity, and anti-HIV activity of N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a potent non-nucleoside inhibitor of HIV reverse transcriptase.
Arzneimittel-Forschung 2007;57(7):483-96.
2007: DuMez Darin; Venkatachalam Taracad K; Uckun Fatih M
Large-scale synthesis of GMP grade N'- [2-(2-thiophene) ethyl]-N'- [2- (5-bromopyridyl)] -thiourea (HI-443), a new anti-HIV drug candidate.
Arzneimittel-Forschung 2007;57(6):330-8.
2007: Uckun Fatih M; Erbeck Douglas; Qazi Sanjive; Venkatachalam Taracad; Tibbles Heather E; Vassilev Alexei
Effect of targeting janus kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli(min) mouse model of familial adenomatous polyposis.
Arzneimittel-Forschung 2007;57(6):320-9.
2007: Uckun Fatih M; Qazi Sanjive; Venkatachalam Taracad
N'-[2-(2-thiophene) ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a rationally designed non-nucleoside reverse transcriptase inhibitor compound with potent anti-HIV activity.
Arzneimittel-Forschung 2007;57(5):278-85.
2007: Uckun Fatih M; Tibbles Heather; Erbeck Douglas; Venkatachalam Taracad K; Qazi Sanjive
In vivo pharmacokinetics and toxicity of a novel hydrophilic oral formulation of the potent non-nucleoside reverse transcriptase inhibitor compound N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443).
Arzneimittel-Forschung 2007;57(4):218-26.
2007: Qazi S; DuMez D; Uckun F M
Meta analysis of advanced cancer survival data using lognormal parametric fitting: a statistical method to identify effective treatment protocols.
Current pharmaceutical design 2007;13(15):1533-44.
2007: Uckun Fatih M; Erbeck Douglas; Tibbles Heather; Qazi Sanjive; Venkatachalam Taracad K
Improved oral bioavailability of anti-HIV agent N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443) in a novel lipophilic formulation.
Arzneimittel-Forschung 2007;57(3):164-70.
2007: DuMez Darin; Venkatachalam Taracad K; Uckun Fatih M
Large-scale synthesis of GMP grade alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13), a new anti-cancer drug candidate.
Arzneimittel-Forschung 2007;57(3):155-63.
2007: Uckun Fatih M; DuMez Darin; Qazi Sanjive; Tibbles Heather; Venkatachalam Taracad K
Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study.
Arzneimittel-Forschung 2007;57(2):112-21.
2007: Uckun Fatih M; Tibbles Heather; Venkatachalam Taracad; DuMez Darin; Erbeck Douglas
Preclinical toxicity and pharmacokinetics of the Bruton's tyrosine kinase-targeting anti-leukemic drug candidate, alpha-cyano-beta-hydroxy-beta-methyl-N- (2,5-dibromophenyl) propenamide (LFM-A13).
Arzneimittel-Forschung 2007;57(1):31-46.
2006: Uckun Fatih M; Morar Sanda; Qazi Sanjive
Vinorelbine-based salvage chemotherapy for therapy-refractory aggressive leukaemias.
British journal of haematology 2006;135(4):500-8.
2006: Venkatachalam T K; Sarquis M; Qazi S; Uckun F M
Effect of alkyl groups on the cellular hydrolysis of stavudine phosphoramidates.
Bioorganic & medicinal chemistry 2006;14(18):6420-33.
2006: D'Cruz Osmond J; Uckun Fatih M
Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):329-50.
2006: Venkatachalam T K; Qazi S; Uckun F M
Synthesis and metabolism of naphthyl substituted phosphoramidate derivatives of stavudine.
Bioorganic & medicinal chemistry 2006;14(15):5161-77.
2006: D'Cruz Osmond J; Uckun Fatih M
Novel broad-spectrum thiourea non-nucleoside inhibitors for the prevention of mucosal HIV transmission.
Current HIV research 2006;4(3):329-45.
2006: Vassilev Alexei O; Tibbles Heather E; DuMez Darin; Venkatachalam Taracad K; Uckun Fatih M
Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors.
Current drug targets 2006;7(3):327-43.
2006: D'Cruz Osmond J; Uckun Fatih M
Dawn of non-nucleoside inhibitor-based anti-HIV microbicides.
The Journal of antimicrobial chemotherapy 2006;57(3):411-23.
2006: Uckun Fatih M; Venkatachalam Taracad K; Qazi Sanjive
Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses.
Arzneimittel-Forschung 2006;56(2A):193-203.
2006: Uckun Fatih M; Waurzyniak Barbara; Tibbles Heather; Venkatachalam Taracad K; Erbeck Doug
In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats.
Arzneimittel-Forschung 2006;56(2A):176-92.
2006: Venkatachalam Taracad K; Qazi Sanjive; Uckun Fatih M
Site-specific enzymatic activation of the anti-HIV agent stampidine.
Arzneimittel-Forschung 2006;56(2A):167-75.
2006: D'Cruz Osmond J; Erbeck Douglas; Uckun Fatih M
Developmental safety profile of the anti-HIV agent stampidine in rabbits.
Arzneimittel-Forschung 2006;56(2A):159-66.
2006: Venkatachalam Taracad K; Qazi Sanjive; Uckun Fatih M
Synthesis, separation and anti-HIV activity of distereoisomers of N-[p-(4-bromophenyl) -2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester (stampidine).
Arzneimittel-Forschung 2006;56(2A):152-8.
2006: DuMez Darin; Venkatachalam Taracad K; Uckun Fatih M
Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent.
Arzneimittel-Forschung 2006;56(2A):136-51.
2006: Uckun Fatih M
Stampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activity.
Arzneimittel-Forschung 2006;56(2A):121-35.
2006: Uckun Fatih M
Unmet challenges in HIV therapy and potential of stampidine.
Arzneimittel-Forschung 2006;56(2A):117-20.
2006: D'Cruz Osmond J; Uckun Fatih M
Influence of long-term stability conditions on microbicidal nucleoside prodrug (WHI-07)-loaded gel-microemulsion.
AAPS PharmSciTech 2006;7(3):73.
2006: Lundell Kathleen; Qazi Sanjive; Eddy Linda; Uckun Fatih M
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
Arzneimittel-Forschung 2006;56(6):399-404.
2005: D'Cruz Osmond J; Uckun Fatih M
Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide.
Molecular human reproduction 2005;11(10):767-77.
2005: Venkatachalam T K; Samuel P; Qazi S; Uckun F M
Effect of change in nucleoside structure on the activation and antiviral activity of phosphoramidate derivatives.
Bioorganic & medicinal chemistry 2005;13(18):5408-23.
2005: D'Cruz Osmond J; Uckun Fatih M
Vaginal contraceptive activity of a chelated vanadocene.
Contraception 2005;72(2):146-56.
2005: D'Cruz Osmond J; Uckun Fatih M
Stampidine: a selective oculo-genital microbicide.
The Journal of antimicrobial chemotherapy 2005;56(1):10-9.
2005: Venkatachalam T K; Samuel P; Qazi S; Uckun F M
Protease-mediated enzymatic hydrolysis and activation of aryl phosphoramidate derivatives of stavudine.
European journal of medicinal chemistry 2005;40(5):452-66.
2005: Uckun F M; Venkatachalam T K; Erbeck D; Chen C L; Petkevich A S; Vassilev A
Zidampidine, an aryl phosphate derivative of AZT: in vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus.
Bioorganic & medicinal chemistry 2005;13(9):3279-88.
2005: Venkatachalam T K; Samuel P; Uckun F M
Enzymatic hydrolysis of stampidine and other stavudine phosphoramidates in the presence of mammalian proteases.
Bioorganic & medicinal chemistry 2005;13(7):2651-5.
2005: Cetkovic-Cvrlje Marina; Uckun Fatih M
Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin.
Clinical immunology (Orlando, Fla.) 2005;114(3):299-306.
2005: Uckun Fatih M; Rustamova Larisa; Vassilev Alexei O; Tibbles Heather E; Petkevich Alexander S
CNS activity of Pokeweed anti-viral protein (PAP) in mice infected with lymphocytic choriomeningitis virus (LCMV).
BMC infectious diseases 2005;5(1):9.
2005: D'Cruz Osmond J; Samuel Peter; Uckun Fatih M
Conceival, a novel noncontraceptive vaginal vehicle for lipophilic microbicides.
AAPS PharmSciTech 2005;6(1):E56-64.
2005: D'Cruz Osmond J; Erbeck Douglas; Uckun Fatih M
A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate.
Toxicologic pathology 2005;33(4):465-76.
2005: Uckun Fatih M; Qazi Sanjive; Venkatachalam T K
In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs.
Arzneimittel-Forschung 2005;55(4):223-31.
2005: Benyumov Alexey O; Venkatachalam Taracad K; Grigoriants Olga O; Vassilev Alexei O; Tibbles Heather E; Downs Suzanne; Dumezb Darin; Uckun Fatih M
Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds. Studies using human acute lymphoblastic leukemia cells and the zebrafish model.
Arzneimittel-Forschung 2005;55(2):114-22.
2005: Uckun Fatih M; Tai Hung-Liang; D'Cruz Osmond J
Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).
Arzneimittel-Forschung 2005;55(1):50-65.
2004: D'Cruz Osmond J; Samuel Peter; Uckun Fatih M
PHI-443: a novel noncontraceptive broad-spectrum anti-human immunodeficiency virus microbicide.
Biology of reproduction 2004;71(6):2037-47.
2004: Cetkovic-Cvrlje Marina; Uckun Fatih M
Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft-versus-host disease (GVHD) in a murine allogeneic bone marrow transplantation model.
British journal of haematology 2004;126(6):821-7.
2004: Venkatachalam T K; Yu G; Samuel P; Qazi S; Pendergrass S; Uckun F M
A comparative study of the hydrolysis pathways of substituted aryl phosphoramidate versus aryl thiophosphoramidate derivatives of stavudine.
European journal of medicinal chemistry 2004;39(8):665-83.
2004: Venkatachalam T K; Mao C; Uckun Fatih M
Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds.
Bioorganic & medicinal chemistry 2004;12(15):4275-84.
2004: Uckun Fatih M; Petkevich Alexander S; Vassilev Alexei O; Tibbles Heather E; Titov Leonid
Correction: Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus.
BMC infectious diseases 2004;4():14.
2004: Venkatachalam T K; Samuel P; Li G; Qazi S; Mao C; Pendergrass S; Uckun F M
Lipase-mediated stereoselective hydrolysis of stampidine and other phosphoramidate derivatives of stavudine.
Bioorganic & medicinal chemistry 2004;12(12):3371-81.
2004: Venkatachalam Taracad K; Mao Chen; Uckun Fatih M
Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives.
Biochemical pharmacology 2004;67(10):1933-46.
2004: Heerema N A; Nachman J B; Sather H N; La M K; Hutchinson R; Lange B J; Bostrom B; Steinherz P G; Gaynon P S; Uckun F M;
Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(5):939-47.
2004: D'Cruz Osmond J; Waurzyniak Barbara; Uckun Fatih M
Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats.
Antimicrobial agents and chemotherapy 2004;48(4):1082-8.
2004: D'Cruz Osmond J; Waurzyniak Barbara; Uckun Fatih M
Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein.
Toxicologic pathology 2004;32(2):212-21.
2004: Cetkovic-Cvrlje Marina; Uckun Fatih M
Targeting Janus kinase 3 in the treatment of leukemia and inflammatory diseases.
Archivum immunologiae et therapiae experimentalis 2004;52(2):69-82.
2004: Uckun Fatih M; Pendergrass Sharon; Qazi Sanjive; Samuel P; Venkatachalam T K
Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus.
European journal of medicinal chemistry 2004;39(3):225-34.
2004: D'Cruz Osmond J; Uckun Fatih M
Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.
Fertility and sterility 2004;81 Suppl 1():831-41.
2004: Uckun Fatih M; Petkevich Alexander S; Vassilev Alexei O; Tibbles Heather E; Titov Leonid
Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus.
BMC infectious diseases 2004;4():1.
2004: Uckun Fatih M; Chen Chun-Lin; Liu Xing-Ping; Dibirdik Ilker; Venkatachalam Taracad K
In vitro and in vivo pharmacokinetic features and metabolism of the novel cytotoxic nucleoside analog 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003).
Arzneimittel-Forschung 2004;54(11):732-45.
2004: Uckun Fatih M; Vassilev Alexei O; Dibirdik Ilker; Liu Xing-Ping; Erbeck Douglas; Tibbles Heather E; Qazi Sanjive; Venkatachalam Taracad K
Anti-cancer activity profile of 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003), a novel nucleoside analog.
Arzneimittel-Forschung 2004;54(11):715-31.
2004: Kurinov Igor V; Rajamohan Francis; Uckun Fatih M
High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein.
Arzneimittel-Forschung 2004;54(10):692-702.
2004: Tibbles Heather E; Samuel Peter; Erbeck Doug; Mahajan Sandeep; Uckun Fatih M
In vivo toxicity and antithrombotic profile of the oral formulation of the antileukemic agent, LFM-A13-F.
Arzneimittel-Forschung 2004;54(6):330-9.
2004: D'Cruz O J; Waurzyniakt B; Uckun F M
A 13-week subchronic intravaginal toxicity study of pokeweed antiviral protein in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(4):342-51.
2004: Uckun Fatih M; Mao Chen
Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia.
Current pharmaceutical design 2004;10(10):1083-91.
2004: Uckun Fatih M; Pendergrass Sharon; Qazi Sanjive; Venkatachalam Taracad K
In vitro activity of stampidine against primary clinical human immunodeficiency virus isolates.
Arzneimittel-Forschung 2004;54(1):69-77.
2004: D'Cruz Osmond J; Uckun Fatih M
Clinical development of microbicides for the prevention of HIV infection.
Current pharmaceutical design 2004;10(3):315-36.
2003: D'Cruz Osmond J; Samuel Peter; Waurzyniak Barbara; Uckun Fatih M
Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.
Biology of reproduction 2003;69(6):1843-51.
2003: D'Cruz Osmond J; Erbeck Douglas; Uckun Fatih M
Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits.
Toxicologic pathology 2003;31(6):698-708.
2003: Uckun Fatih M; Vassilev Alexei; Bartell Steve; Zheng Yaguo; Mahajan Sandeep; Tibbles Heather E
The anti-leukemic Bruton's tyrosine kinase inhibitor alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13) prevents fatal thromboembolism.
Leukemia & lymphoma 2003;44(9):1569-77.
2003: Levy Adam S; Sather Harland N; Steinherz Peter G; Sowers Rebecca; La Mei; Moscow Jeffrey A; Gaynon Paul S; Uckun Fatih M; Bertino Joseph R; Gorlick Richard;
Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2003;25(9):688-95.
2003: Goodman Patricia A; Wood Carla M; Vassilev Alexei O; Mao Chen; Uckun Fatih M
Defective expression of Bruton's tyrosine kinase in acute lymphoblastic leukemia.
Leukemia & lymphoma 2003;44(6):1011-8.
2003: Kurinov Igor V; Uckun Fatih M
High resolution X-ray structure of potent anti-HIV pokeweed antiviral protein-III.
Biochemical pharmacology 2003;65(10):1709-17.
2003: Kees U R; Heerema N A; Kumar R; Watt P M; Baker D L; La M K; Uckun F M; Sather H N
Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG).
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(5):887-93.
2003: D'Cruz Osmond J; Uckun Fatih M
Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits.
Fertility and sterility 2003;79(4):864-72.
2003: Uckun Fatih M; Chen Chun-Lin; Samuel Peter; Pendergrass Sharon; Venkatachalam T K; Waurzyniak Barbara; Qazi Sanjive
In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats.
Antimicrobial agents and chemotherapy 2003;47(4):1233-40.
2003: Cetkovic-Cvrlje Marina; Dragt Angela L; Vassilev Alexei; Liu Xing-Ping; Uckun Fatih M
Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice.
Clinical immunology (Orlando, Fla.) 2003;106(3):213-25.
2003: Venkatachalam T K; Qazi S; Samuel P; Uckun F M
Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release.
Bioorganic & medicinal chemistry 2003;11(6):1095-105.
2003: Wood Carla M; Goodman Patricia A; Vassilev Alexei O; Uckun Fatih M
CD95 (APO-1/FAS) deficiency in infant acute lymphoblastic leukemia: detection of novel soluble Fas splice variants.
European journal of haematology 2003;70(3):156-71.
2003: Uckun Fatih M; Rajamohan Francis; Pendergrass Sharon; Ozer Zahide; Waurzyniak Barbara; Mao Chen
Structure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activity.
Antimicrobial agents and chemotherapy 2003;47(3):1052-61.
2003: D'Cruz Osmond J; Dong Yanhong; Uckun Fatih M
Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Biochemical and biophysical research communications 2003;302(2):253-64.
2003: Liu Xing-Ping; Narla Rama Krishna; Uckun Fatih M
Organic phenyl arsonic acid compounds with potent antileukemic activity.
Bioorganic & medicinal chemistry letters 2003;13(3):581-3.
2003: Venkatachalam Taracad K; Qazi Sanjive; Samuel Peter; Uckun Fatih M
Inhibition of mast cell leukotriene release by thiourea derivatives.
Bioorganic & medicinal chemistry letters 2003;13(3):485-8.
2003: Qazi Sanjive; Samuel N K Peter; Venkatachalam T K; Uckun Fatih M
Evaluating dissolution profiles of an anti-HIV agent using ANOVA and non-linear regression models in JMP software.
International journal of pharmaceutics 2003;252(1-2):27-39.
2003: Cetkovic-Cvrlje Marina; Dragt Angela L; Uckun Fatih M
Prevention of islet allograft rejection in diabetic mice by targeting Janus Kinase 3 with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1).
Arzneimittel-Forschung 2003;53(9):648-54.
2003: D'Cruz Osmond J; Uckun Fatih M
Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in rabbits.
Arzneimittel-Forschung 2003;53(7):515-21.
2003: Uckun Fatih M; D'Cruz Osmond J; Liu Xing-Ping; Narla Rama Krishna
Phenylarsonic acid compounds with broad-spectrum and potent cytotoxic activity against human cancer cells.
Arzneimittel-Forschung 2003;53(6):428-39.
2003: Uckun Fatih M; Chen Chun-Lin; Lisowski Elizabeth; Mitcheltree Greg C; Venkatachalam Taracad K; Erbeck Douglas; Chen Hao; Waurzyniak Barbara
Toxicity and pharmacokinetics of stampidine in mice and rats.
Arzneimittel-Forschung 2003;53(5):357-67.
2002: D'Cruz Osmond J; Uckun Fatih M
Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07).
The Journal of antimicrobial chemotherapy 2002;50(6):793-803.
2002: D'Cruz Osmond J; Uckun Fatih M
Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity.
Expert opinion on investigational drugs 2002;11(12):1829-36.
2002: D'Cruz Osmond J; Venkatachalam Taracad K; Mao Chen; Qazi Sanjive; Uckun Fatih M
Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Biology of reproduction 2002;67(6):1959-74.
2002: Chen Chun-Lin; Yu Gengli; Venkatachalam T K; Uckun Fatih M
Metabolism of stavudine-5'-[p-bromophenyl methoxyalaninyl phosphate], stampidine, in mice, dogs, and cats.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(12):1523-31.
2002: Zhu De-Min; Tibbles Heather E; Vassilev Alexei O; Uckun Fatih M
SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells.
Leukemia & lymphoma 2002;43(11):2165-70.
2002: D'Cruz Osmond J; Waurzyniak Barbara; Uckun Fatih M
A 13-week subchronic intravaginal toxicity study of the novel broad-spectrum anti-HIV and spermicidal agent, N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (PHI-346) in mice.
Toxicologic pathology 2002;30(6):687-95.
2002: Uckun Fatih M; Pendergrass Sharon; Venkatachalam T K; Qazi Sanjive; Richman Douglas
Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations.
Antimicrobial agents and chemotherapy 2002;46(11):3613-6.
2002: Uckun Fatih M; Qazi Sanjive; Pendergrass Sharon; Lisowski Elizabeth; Waurzyniak Barbara; Chen Chun-Lin; Venkatachalam T K
In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice.
Antimicrobial agents and chemotherapy 2002;46(11):3428-36.
2002: Venkatachalam T K; Samuel P; Kourinov I V; Uckun F M
Synthesis and anti-HIV activity of carbamates of antiviral agent stavudine.
Antiviral chemistry & chemotherapy 2002;13(5):289-97.
2002: D'Cruz Osmond J; Erbeck Douglas; Waurzyniak Barbara; Uckun Fatih M
Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent.
Toxicology 2002;179(1-2):61-77.
2002: Vassilev Alexei O; Lorenz David R; Tibbles Heather E; Uckun Fatih M
Role of the leukemia-associated transcription factor STAT3 in platelet physiology.
Leukemia & lymphoma 2002;43(7):1461-7.
2002: Cetkovic-Cvrlje Marina; Roers Bertram A; Schonhoff Dawn; Waurzyniak Barbara; Liu Xing-Ping; Uckun Fatih M
Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor.
Leukemia & lymphoma 2002;43(7):1447-53.
2002: Malaviya Ravi; Navara Christopher; Uckun Fatih M
Augmentation of mast cell bactericidal activity by the anti-leukemic drug, 4-(3'bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline.
Leukemia & lymphoma 2002;43(6):1329-32.
2002: Uckun Fatih M; Roers Bertram A; Waurzyniak Barbara; Liu Xing-Ping; Cetkovic-Cvrlje Marina
Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model.
Blood 2002;99(11):4192-9.
2002: Uckun Fatih M; Samuel P; Qazi S; Chen C; Pendergrass S; Venkatachalam T K
Effects of aryl substituents on the anti-HIV activity of the arylphosphoramidate derivatives of stavudine.
Antiviral chemistry & chemotherapy 2002;13(3):197-203.
2002: Tibbles Heather; Vassilev Alexei; Uckun Fatih M
A dual function anti-leukemic agent with anti-thrombotic activity.
Leukemia & lymphoma 2002;43(5):1121-7.
2002: Uckun Fatih M; Zheng Yaguo; Cetkovic-Cvrlje Marina; Vassilev Alexei; Lisowski Elizabeth; Waurzyniak Barbara; Chen Hao; Carpenter Randy; Chen Chun-Lin
In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1224-33.
2002: Sun Lei; Kerawalla Hoshnuwar; Wu Xian; Lehnert Matthew S; Uckun Fatih M
Expression of a unique helios isoform in human leukemia cells.
Leukemia & lymphoma 2002;43(4):841-9.
2002: Tibbles Heather E; Navara Christopher S; Hupke Michael A; Vassilev Alexei O; Uckun Fatih M
Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions.
Biochemical and biophysical research communications 2002;292(4):987-91.
2002: Heerema Nyla A; Sather Harland N; Sensel Martha G; La Mei K L; Hutchinson Raymond J; Nachman James B; Reaman Gregory H; Lange Beverly J; Steinherz Peter G; Bostrom Bruce C; Gaynon Paul S; Uckun Fatih M
Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia.
Cancer 2002;94(4):1102-10.
2002: Uckun Fatih M; Liu Xing Ping; D'Cruz Osmond J
Human sperm immobilizing activity of aminophenyl arsenic acid and its N-substituted quinazoline, pyrimidine, and purine derivatives: protective effect of glutathione.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(1):57-64.
2002: Malaviya Ravi; Uckun Fatih M
Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):421-6.
2002: D'Cruz Osmond J; Waurzyniak Barbara; Uckun Fatih M
Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene acetylacetonato monotriflate in mice.
Toxicology 2002;170(1-2):31-43.
2002: Uckun Fatih M; Thoen Jason; Chen Hao; Sudbeck Elise; Mao Chen; Malaviya Ravi; Liu Xing-Ping; Chen Chun-Lin
CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(1):74-85.
2002: Kotchevar Ann T; Perrey David A; Uckun Fatih M
A degradation study of a series of chloromethyl and diazomethyl ketone anti-leukemic agents.
Drug development and industrial pharmacy 2002;28(2):143-9.
2001: Malaviya R; Vassilev A; Uckun F M
2,4,6-Trihydroxy-alpha-p-methoxyphenylacetophenone (Compound D-58) is a potent inhibitor of allergic reactions.
American journal of therapeutics 2001;8(6):417-24.
2001: Uckun F M
Rationally designed anti-mitotic agents with pro-apoptotic activity.
Current pharmaceutical design 2001;7(16):1627-39.
2001: Mao C; Zhou M; Uckun F M
Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
The Journal of biological chemistry 2001;276(44):41435-43.
2001: D'Cruz O J; Uckun F M
Effect of pretreatment of semen with pokeweed antiviral protein on pregnancy outcome in the rabbit model.
Fertility and sterility 2001;76(4):830-3.
2001: D'Cruz O J; Waurzyniak B; Uckun F M
Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene dithiocarbamate in mice.
Contraception 2001;64(3):177-85.
2001: Malaviya R; Uckun F M
Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice.
American journal of therapeutics 2001;8(5):309-16.
2001: Cetkovic-Cvrlje M; Roers B A; Waurzyniak B; Liu X P; Uckun F M
Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice.
Blood 2001;98(5):1607-13.
2001: D'Cruz O J; Uckun F M
Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles.
Contraception 2001;64(2):113-23.
2001: Malaviya R; Navara C; Uckun F M
Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria.
Immunity 2001;15(2):313-21.
2001: Rajamohan F; Ozer Z; Mao C; Uckun F M
Active center cleft residues of pokeweed antiviral protein mediate its high-affinity binding to the ribosomal protein L3.
Biochemistry 2001;40(31):9104-14.
2001: D'Cruz O J; Vassilev A O; Uckun F M
Members of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm.
Fertility and sterility 2001;76(2):258-66.
2001: Venkatachalam T K; Mao C; Uckun F M
Stereochemistry as a major determinant of the anti-HIV activity of chiral naphthyl thiourea compounds.
Antiviral chemistry & chemotherapy 2001;12(4):213-21.
2001: Goodman P A; Wood C M; Vassilev A; Mao C; Uckun F M
Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia.
Oncogene 2001;20(30):3969-78.
2001: D'Cruz O J; Uckun F M
Bis(4,7-dimethyl and 5-dinitro-1,10-phenanthroline) sulfato-oxovanadium(IV)-mediated in vivo male germ cell apoptosis.
Journal of applied toxicology : JAT 2001;21(4):331-9.
2001: D'Cruz O J; Uckun F M
Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07).
Journal of applied toxicology : JAT 2001;21(4):317-22.
2001: Chen C L; Venkatachalam T K; Zhu Z H; Uckun F M
In vivo pharmacokinetics and metabolism of anti-human immunodeficiency virus agent D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] (SAMPIDINE) in mice.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(7):1035-41.
2001: Uckun F M; Pallisgaard N; Hokland P; Navara C; Narla R; Gaynon P S; Sather H; Heerema N
Expression of TEL-AML1 fusion transcripts and response to induction therapy in standard risk acute lymphoblastic leukemia.
Leukemia & lymphoma 2001;42(1-2):41-56.
2001: Rajamohan F; Mao C; Uckun F M
Binding interactions between the active center cleft of recombinant pokeweed antiviral protein and the alpha-sarcin/ricin stem loop of ribosomal RNA.
The Journal of biological chemistry 2001;276(26):24075-81.
2001: Krishna Narla R; Navara C; Sarquis M; Uckun F M
Chemosensitivity of TEL-AML1 fusion transcript positive acute lymphoblastic leukemia cells.
Leukemia & lymphoma 2001;41(5-6):615-23.
2001: Tibbles H E; Vassilev A; Wendorf H; Schonhoff D; Zhu D; Lorenz D; Waurzyniak B; Liu X P; Uckun F M
Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation.
The Journal of biological chemistry 2001;276(21):17815-22.
2001: Ghosh P; Ghosh S; Navara C; Narla R K; Benyumov A; Uckun F M
X-ray structure, solution properties, and biological activity profile of vanadocene(IV) acetylacetonate complex,.
Journal of inorganic biochemistry 2001;84(3-4):241-53.
2001: Navara C S; Benyumov A; Vassilev A; Narla R K; Ghosh P; Uckun F M
Vanadocenes as potent anti-proliferative agents disrupting mitotic spindle formation in cancer cells.
Anti-cancer drugs 2001;12(4):369-76.
2001: D'Cruz O J; Uckun F M
Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(2):373-8.
2001: Venkatachalam T K; Sudbeck E A; Mao C; Uckun F M
Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds.
Bioorganic & medicinal chemistry letters 2001;11(4):523-8.
2001: Uckun F M; Gaynon P S; Stram D O; Sensel M G; Sarquis M B; Willoughby M
Bone marrow leukemic progenitor cell content in pediatric T-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse.
Leukemia & lymphoma 2001;40(3-4):279-85.
2001: Malavija R; Chen C L; Liu X P; Uckun F M
In vivo pharmacokinetics and anti-anaphylactic activity of the novel mast cell inhibitor 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131).
American journal of therapeutics 2001;8(1):35-9.
2001: Kotchevar A T; Ghosh P; DuMez D D; Uckun F M
Induction of aerobic peroxidation of liposomal membranes by bis(cyclopentadienyl)-vanadium(IV) (acetylacetonate) complexes.
Journal of inorganic biochemistry 2001;83(2-3):151-60.
2001: Ghosh S; Jennissen J D; Liu X P; Uckun F M
4-[3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate and 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride.
Acta crystallographica. Section C, Crystal structure communications 2001;57(Pt 1):76-8.
2001: D'Cruz O J; Yiv S H; Waurzyniak B; Uckun F M
Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide.
Fertility and sterility 2001;75(1):115-24.
2001: D'Cruz O J; Uckun F M
Pokeweed antiviral protein: a potential nonspermicidal prophylactic antiviral agent.
Fertility and sterility 2001;75(1):106-14.
2001: D'Cruz O J; Uckun F M
Intravaginal toxicity studies of a gel-microemulsion formulation of spermicidal vanadocenes in rabbits.
Toxicology and applied pharmacology 2001;170(2):104-12.
2001: D'Cruz O J; Yiv S H; Uckun F M
GM-144, a novel lipophilic vaginal contraceptive gel-microemulsion.
AAPS PharmSciTech 2001;2(2):E5.
2001: Chen C L; Venkatachalam T K; Waurzyniak B; Chelstrom L; Uckun F M
In vivo toxicity, pharmacokinetic features and tissue distribution of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236), a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Arzneimittel-Forschung 2001;51(7):574-81.
2000: Malaviya R; Chen C L; Navara C; Malaviya R; Liu X P; Keenan M; Waurzyniak B; Uckun F M
Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97).
The Journal of pharmacology and experimental therapeutics 2000;295(3):912-26.
2000: D'Cruz O J; Dong Y; Uckun F M
Apoptosis-inducing oxovanadium(IV) complexes of 1,10-phenanthroline against human ovarian cancer.
Anti-cancer drugs 2000;11(10):849-58.
2000: Mao C; Sudbeck E A; Venkatachalam T K; Uckun F M
Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase.
Biochemical pharmacology 2000;60(9):1251-65.
2000: Zhu D M; Uckun F M
Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells.
Leukemia & lymphoma 2000;39(3-4):343-54.
2000: Sudbeck E A; Jennissen J D; Liu X P; Uckun F M
An inhibitor of Janus kinase 3:4-(4-hydroxyphenylamino)-6, 7-dimethoxyquinazolin-1-ium chloride methanol solvate.
Acta crystallographica. Section C, Crystal structure communications 2000;56 ( Pt 10)():1282-3.
2000: Venkatachalam T K; Sudbec E A; Mao C; Uckun F M
Piperidinylethyl, phenoxyethyl and fluoroethyl bromopyridyl thiourea compounds with potent anti-HIV activity.
Antiviral chemistry & chemotherapy 2000;11(5):329-36.
2000: Venkatachalam T K; Sudbeck E A; Mao C; Uckun F M
Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2000;10(18):2071-4.
2000: Kurinov I V; Mao C; Irvin J D; Uckun F M
X-ray crystallographic analysis of pokeweed antiviral protein-II after reductive methylation of lysine residues.
Biochemical and biophysical research communications 2000;275(2):549-52.
2000: Uckun F M; Stork L; Seibel N; Sarquis M; Bedros C; Sather H; Sensel M; Reaman G H; Gaynon P S
Residual bone marrow leukemic progenitor cell burden after induction chemotherapy in pediatric patients with acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):3123-30.
2000: D'Cruz O J; Uckun F M
Vanadocene-mediated in vivo male germ cell apoptosis.
Toxicology and applied pharmacology 2000;166(3):186-95.
2000: D'Cruz O J; Waurzyniak B; Yiv S H; Uckun F M
Evaluation of subchronic (13-week) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound whi-07) in B(6)C(3)F(1) mice.
Journal of applied toxicology : JAT 2000;20(4):319-25.
2000: Zhu D M; Uckun F M
Z-Phe-Gly-NHO-Bz, an inhibitor of cysteine cathepsins, induces apoptosis in human cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):2064-9.
2000: Ghosh P; D'Cruz O J; Narla R K; Uckun F M
Apoptosis-inducing vanadocene compounds against human testicular cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1536-45.
2000: D'Cruz O J; Vassilev A; Uckun F M
Evaluation of boar sperm as a model system to study the mechanism of spermicidal activity of vanadocenes.
Biochemical and biophysical research communications 2000;270(3):826-30.
2000: Heerema N A; Sather H N; Sensel M G; Lee M K; Hutchinson R; Nachman J B; Lange B J; Steinherz P G; Bostrom B; Gaynon P S; Uckun F M
Prognostic significance of cytogenetic abnormalities of chromosome arm 12p in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Cancer 2000;88(8):1945-54.
2000: Dong Y; Narla R K; Sudbeck E; Uckun F M
Synthesis, X-ray structure, and anti-leukemic activity of oxovanadium(IV) complexes.
Journal of inorganic biochemistry 2000;78(4):321-30.
2000: Uckun F M; Mao C; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Venkatachalam T K
N-[2-(4-methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1.
Antiviral chemistry & chemotherapy 2000;11(2):135-40.
2000: Perrey D A; Scannell M P; Narla R K; Uckun F M
The S-alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds.
Bioorganic & medicinal chemistry letters 2000;10(6):551-2.
2000: Perrey D A; Narla R K; Uckun F M
Cysteine chloromethyl and diazomethyl ketone derivatives with potent anti-leukemic activity.
Bioorganic & medicinal chemistry letters 2000;10(6):547-9.
2000: Rajamohan F; Doumbia S O; Engstrom C R; Pendergras S L; Maher D L; Uckun F M
Expression of biologically active recombinant pokeweed antiviral protein in methylotrophic yeast Pichia pastoris.
Protein expression and purification 2000;18(2):193-201.
2000: Heerema N A; Sather H N; Sensel M G; Lee M K; Hutchinson R; Lange B J; Bostrom B C; Nachman J B; Steinherz P G; Gaynon P S; Uckun F M
Clinical significance of deletions of chromosome arm 6q in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Leukemia & lymphoma 2000;36(5-6):467-78.
2000: Rajamohan F; Pugmire M J; Kurinov I V; Uckun F M
Modeling and alanine scanning mutagenesis studies of recombinant pokeweed antiviral protein.
The Journal of biological chemistry 2000;275(5):3382-90.
2000: D'Cruz O J; Waurzyniak B; Yiv S H; Uckun F M
Evaluation of subchronic (13 weeks) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in B(6)C(3)F(1) mice.
Contraception 2000;61(1):69-76.
2000: Venkatachalam T K; D'Cruz O J; Uckun F M
Importance of the alanine methyl ester side chain for the biological activity profile of dual-function phenyl phosphate derivatives of bromo-methoxy-zidovudine.
Antiviral chemistry & chemotherapy 2000;11(1):31-9.
2000: Malaviya R; Uckun F M
Histamine as an autocrine regulator of leukemic cell proliferation.
Leukemia & lymphoma 2000;36(3-4):367-73.
2000: Dong Y; Venkatachalam T K; Narla R K; Trieu V N; Sudbeck E A; Uckun F M
Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2000;10(1):87-90.
1999: Sudbeck E A; Jennissen J D; Venkatachalam T K; Uckun F M
Inhibitor of HIV-1 reverse transcriptase: N'-(5-bromo-2-pyridyl)-N-[2-(2,5-dimethoxyphenyl)ethyl]thiourea.
Acta crystallographica. Section C, Crystal structure communications 1999;55 ( Pt 12)():2122-4.
1999: Ghosh S; Zheng Y; Jun X; Mahajan S; Mao C; Sudbeck E A; Uckun F M
Specificity of alpha-cyano-beta-hydroxy-beta-methyl-n-[4-(trifluoromethoxy)phe nyl]-propenamide as an inhibitor of the epidermal growth factor receptor tyrosine kinase.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4264-72.
1999: Uckun F M; Messinger Y; Chen C L; O'Neill K; Myers D E; Goldman F; Hurvitz C; Casper J T; Levine A
Treatment of therapy-refractory B-lineage acute lymphoblastic leukemia with an apoptosis-inducing CD19-directed tyrosine kinase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):3906-13.
1999: Uckun F M; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Mao C; Venkatachalam T K
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
Bioorganic & medicinal chemistry letters 1999;9(24):3411-6.
1999: Heerema N A; Nachman J B; Sather H N; Sensel M G; Lee M K; Hutchinson R; Lange B J; Steinherz P G; Bostrom B; Gaynon P S; Uckun F
Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukemia: a report from the children's cancer group.
Blood 1999;94(12):4036-45.
1999: Chen C L; Levine A; Rao A; O'Neill K; Messinger Y; Myers D E; Goldman F; Hurvitz C; Casper J T; Uckun F M
Clinical pharmacokinetics of the CD19 receptor-directed tyrosine kinase inhibitor B43-Genistein in patients with B-lineage lymphoid malignancies.
Journal of clinical pharmacology 1999;39(12):1248-55.
1999: Sun L; Goodman P A; Wood C M; Crotty M L; Sensel M; Sather H; Navara C; Nachman J; Steinherz P G; Gaynon P S; Seibel N; Vassilev A; Juran B D; Reaman G H; Uckun F M
Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(12):3753-66.
1999: Uckun F M; Bellomy K; O'Neill K; Messinger Y; Johnson T; Chen C L
Toxicity, biological activity, and pharmacokinetics of TXU (anti-CD7)-pokeweed antiviral protein in chimpanzees and adult patients infected with human immunodeficiency virus.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1301-7.
1999: Kurinov I V; Rajamohan F; Venkatachalam T K; Uckun F M
X-ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA.
Protein science : a publication of the Protein Society 1999;8(11):2399-405.
1999: Ghosh S; Narla R K; Zheng Y; Liu X P; Jun X; Mao C; Sudbeck E A; Uckun F M
Structure-based design of potent inhibitors of EGF-receptor tyrosine kinase as anti-cancer agents.
Anti-cancer drug design 1999;14(5):403-10.
1999: Mao C; Sudbeck E A; Venkatachalam T K; Uckun F M
Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus.
Antiviral chemistry & chemotherapy 1999;10(5):233-40.
1999: Uckun F M; Mao C; Pendergrass S; Maher D; Zhu D; Tuel-Ahlgren L; Venkatachalam T K
N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.
Bioorganic & medicinal chemistry letters 1999;9(18):2721-6.
1999: Uckun F M; Gaynon P S; Stram D O; Sensel M G; Sarquis M B; Lazarus K H; Willoughby M
Paucity of leukemic progenitor cells in the bone marrow of pediatric B-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2415-20.
1999: Kurinov I V; Myers D E; Irvin J D; Uckun F M
X-ray crystallographic analysis of the structural basis for the interactions of pokeweed antiviral protein with its active site inhibitor and ribosomal RNA substrate analogs.
Protein science : a publication of the Protein Society 1999;8(9):1765-72.
1999: Rajamohan F; Kurinov I V; Venkatachalam T K; Uckun F M
Deguanylation of human immunodeficiency virus (HIV-1) RNA by recombinant pokeweed antiviral protein.
Biochemical and biophysical research communications 1999;263(2):419-24.
1999: Heerema N A; Sather H N; Sensel M G; Liu-Mares W; Lange B J; Bostrom B C; Nachman J B; Steinherz P G; Hutchinson R; Gaynon P S; Arthur D C; Uckun F M
Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group.
Blood 1999;94(5):1537-44.
1999: Sun L; Crotty M L; Sensel M; Sather H; Navara C; Nachman J; Steinherz P G; Gaynon P S; Seibel N; Mao C; Vassilev A; Reaman G H; Uckun F M
Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2112-20.
1999: Rajamohan F; Engstrom C R; Denton T J; Engen L A; Kourinov I; Uckun F M
High-level expression and purification of biologically active recombinant pokeweed antiviral protein.
Protein expression and purification 1999;16(2):359-68.
1999: Rajamohan F; Venkatachalam T K; Irvin J D; Uckun F M
Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1.
Biochemical and biophysical research communications 1999;260(2):453-8.
1999: Sudbeck E A; Liu X P; Narla R K; Mahajan S; Ghosh S; Mao C; Uckun F M
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1569-82.
1999: Mao C; Sudbeck E A; Venkatachalam T K; Uckun F M
Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
Bioorganic & medicinal chemistry letters 1999;9(11):1593-8.
1999: Mao C; Ozer Z; Zhou M; Uckun F M
X-Ray structure of glycerol kinase complexed with an ATP analog implies a novel mechanism for the ATP-dependent glycerol phosphorylation by glycerol kinase.
Biochemical and biophysical research communications 1999;259(3):640-4.
1999: D'Cruz O J; Uckun F M
Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-human immunodeficiency virus activity.
Biology of reproduction 1999;60(6):1419-28.
1999: D'Cruz O J; Zhu Z; Yiv S H; Chen C L; Waurzyniak B; Uckun F M
WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity.
Contraception 1999;59(5):319-31.
1999: D'Cruz O J; Shih M J; Yiv S H; Chen C L; Uckun F M
Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities.
Molecular human reproduction 1999;5(5):421-32.
1999: Messinger Y; Reaman G H; Ek O; Uckun F M
Evaluation of temozolomide in a SCID mouse model of human B-cell precursor leukemia.
Leukemia & lymphoma 1999;33(3-4):289-93.
1999: Mahajan S; Ghosh S; Sudbeck E A; Zheng Y; Downs S; Hupke M; Uckun F M
Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide].
The Journal of biological chemistry 1999;274(14):9587-99.
1999: Uckun F M; Nachman J B; Sather H N; Sensel M G; Kraft P; Steinherz P G; Lange B; Hutchinson R; Reaman G H; Gaynon P S; Heerema N A
Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy.
Leukemia & lymphoma 1999;33(1-2):101-6.
1999: Reaman G H; Sposto R; Sensel M G; Lange B J; Feusner J H; Heerema N A; Leonard M; Holmes E J; Sather H N; Pendergrass T W; Johnstone H S; O'Brien R T; Steinherz P G; Zeltzer P M; Gaynon P S; Trigg M E; Uckun F M
Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(2):445-55.
1999: Uckun F M; Waurzyniak B J; Sather H N; Sensel M G; Chelstrom L; Nachman J; Gaynon P S; Bostrom B; Ek O; Sarquis M; Steinherz P G; Reaman G H
Prognostic significance of T-lineage leukemic cell growth in SCID mice: a Children's Cancer Group study.
Leukemia & lymphoma 1999;32(5-6):475-87.
1999: Zhu D M; Fang W H; Narla R K; Uckun F M
A requirement for protein kinase C inhibition for calcium-triggered apoptosis in acute lymphoblastic leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):355-60.
1999: D'Cruz O J; Dong Y; Uckun F M
Spermicidal activity of oxovanadium(IV) complexes of 1, 10-phenanthroline, 2,2'-bipyridyl, 5'-bromo-2'-hydroxyacetophenone and derivatives in humans.
Biology of reproduction 1999;60(2):435-44.
1999: Jan S T; Zhu Z; Tai H L; Shih M J; Venkatachalam T K; Uckun F M
AZT-5'-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent.
Antiviral chemistry & chemotherapy 1999;10(1):47-52.
1999: Jan S T; Shih M J; Venkatachalam T K; D'Cruz O J; Chen C L; Uckun F M
Synthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents.
Antiviral chemistry & chemotherapy 1999;10(1):39-46.
1999: Sun L; Heerema N; Crotty L; Wu X; Navara C; Vassilev A; Sensel M; Reaman G H; Uckun F M
Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):680-5.
1998: Waurzyniak B J; Heerema N; Sensel M G; Gaynon P S; Kraft P; Sather H N; Chelstrom L; Reaman G H; Uckun F M
Distinct in vivo engraftment and growth patterns of t(1;19)+/E2A-PBX1+ and t(9;22)+/BCR-ABL+ human leukemia cells in SCID mice.
Leukemia & lymphoma 1998;32(1-2):77-87.
1998: Zhu D M; Narla R K; Fang W H; Chia N C; Uckun F M
Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):2967-76.
1998: Sudbeck E A; Mao C; Vig R; Venkatachalam T K; Tuel-Ahlgren L; Uckun F M
Structure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent nonnucleoside inhibitors of the human immunodeficiency virus reverse transcriptase.
Antimicrobial agents and chemotherapy 1998;42(12):3225-33.
1998: Venkatachalam T K; Tai H L; Vig R; Chen C L; Jan S T; Uckun F M
Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives.
Bioorganic & medicinal chemistry letters 1998;8(22):3121-6.
1998: Ghosh S; Zheng Y; Jun X; Narla R K; Mahajan S; Navara C; Mao C; Sudbeck E A; Uckun F M
Alpha-cyano-beta-hydroxy-beta-methyl-N-[4-(trifluoromethoxy)phenyl] propenamide: an inhibitor of the epidermal growth factor receptor tyrosine kinase with potent cytotoxic activity against breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(11):2657-68.
1998: Uckun F M; Nachman J B; Sather H N; Sensel M G; Kraft P; Steinherz P G; Lange B; Hutchinson R; Reaman G H; Gaynon P S; Heerema N A
Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group.
Cancer 1998;83(9):2030-9.
1998: Vig R; Mao C; Venkatachalam T K; Tuel-Ahlgren L; Sudbeck E A; Uckun F M
Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reserve transcriptase.
Bioorganic & medicinal chemistry 1998;6(10):1789-97.
1998: Narla R K; Liu X P; Klis D; Uckun F M
Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154).
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(10):2463-71.
1998: Vig R; Venkatachalam T K; Uckun F M
D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] as a potent and non-toxic anti-human immunodeficiency virus agent.
Antiviral chemistry & chemotherapy 1998;9(5):445-8.
1998: Vig R; Venkatachalam T K; Jan S T; Uckun F M
Aryl phosphate derivatives of 3'-deoxythymidine are not potent anti-human immunodeficiency virus agents.
Antiviral chemistry & chemotherapy 1998;9(5):439-43.
1998: Ek O; Gaynon P; Zeren T; Chelstrom L M; Myers D E; Uckun F M
Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and L-asparaginase.
Leukemia & lymphoma 1998;31(1-2):143-9.
1998: D'Cruz O J; Venkatachalam T K; Zhu Z; Shih M J; Uckun F M
Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus.
Biology of reproduction 1998;59(3):503-15.
1998: Mao C; Vig R; Venkatachalam T K; Sudbeck E A; Uckun F M
Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 1998;8(16):2213-8.
1998: Uckun F M; Sather H N; Waurzyniak B J; Sensel M G; Chelstrom L; Ek O; Sarquis M B; Nachman J; Bostrom B; Reaman G H; Gaynon P S
Prognostic significance of B-lineage leukemic cell growth in SCID mice: a Children's Cancer Group Study.
Leukemia & lymphoma 1998;30(5-6):503-14.
1998: Uckun F M; Herman-Hatten K; Crotty M L; Sensel M G; Sather H N; Tuel-Ahlgren L; Sarquis M B; Bostrom B; Nachman J B; Steinherz P G; Gaynon P S; Heerema N
Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation.
Blood 1998;92(3):810-21.
1998: Ek O; Yanishevski Y; Zeren T; Waurzyniak B; Gunther R; Chelstrom L; Chandan-Langlie M; Schneider E; Myers D E; Evans W; Uckun F M
In vivo toxicity and pharmacokinetic features of B43(Anti-CD19)-Genistein immunoconjugate.
Leukemia & lymphoma 1998;30(3-4):389-94.
1998: Uckun F M; Waurzyniak B J; Sensel M G; Chelstrom L; Crotty M L; Gaynon P S; Reaman G H
Primary blasts from infants with acute lymphoblastic leukemia cause overt leukemia in SCID mice.
Leukemia & lymphoma 1998;30(3-4):269-77.
1998: D'Cruz O J; Ghosh P; Uckun F M
Spermicidal activity of chelated complexes of bis(cyclopentadienyl)vanadium(IV).
Molecular human reproduction 1998;4(7):683-93.
1998: Ek O; Waurzyniak B; Myers D E; Uckun F M
Antitumor activity of TP3(anti-p80)-pokeweed antiviral protein immunotoxin in hamster cheek pouch and severe combined immunodeficient mouse xenograft models of human osteosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(7):1641-7.
1998: Vig R; Mao C; Venkatachalam T K; Tuel-Ahlgren L; Sudbeck E A; Uckun F M
5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series.
Bioorganic & medicinal chemistry letters 1998;8(12):1461-6.
1998: Nachman J B; Sather H N; Sensel M G; Trigg M E; Cherlow J M; Lukens J N; Wolff L; Uckun F M; Gaynon P S
Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy.
The New England journal of medicine 1998;338(23):1663-71.
1998: Uckun F M; Narla R K; Zeren T; Yanishevski Y; Myers D E; Waurzyniak B; Ek O; Schneider E; Messinger Y; Chelstrom L M; Gunther R; Evans W
In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(5):1125-34.
1998: Kristupaitis D; Dibirdik I; Vassilev A; Mahajan S; Kurosaki T; Chu A; Tuel-Ahlgren L; Tuong D; Pond D; Luben R; Uckun F M
Electromagnetic field-induced stimulation of Bruton's tyrosine kinase.
The Journal of biological chemistry 1998;273(20):12397-401.
1998: Myers D E; Sicheneder A; Clementson D; Dvorak N; Venkatachalam T; Sev A R; Chandan-Langlie M; Uckun F M
Large scale manufacturing of B43(anti-CD19)-genistein for clinical trials in leukemia and lymphoma.
Leukemia & lymphoma 1998;29(3-4):329-38.
1998: Uckun F M; Narla R K; Jun X; Zeren T; Venkatachalam T; Waddick K G; Rostostev A; Myers D E
Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):901-12.
1998: Heerema N A; Sather H N; Sensel M G; Kraft P; Nachman J B; Steinherz P G; Lange B J; Hutchinson R S; Reaman G H; Trigg M E; Arthur D C; Gaynon P S; Uckun F M
Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(4):1270-8.
1998: Ek O; Reaman G H; Crankshaw D L; Chelstrom L M; Myers D E; Uckun F M
Combined therapeutic efficacy of the thymidylate synthase inhibitor ZD1694 (Tomudex) and the immunotoxin B43(anti-CD19)-PAP in a SCID mouse model of human B-lineage acute lymphoblastic leukemia.
Leukemia & lymphoma 1998;28(5-6):509-14.
1998: Uckun F M; Chelstrom L M; Tuel-Ahlgren L; Dibirdik I; Irvin J D; Langlie M C; Myers D E
TXU (anti-CD7)-pokeweed antiviral protein as a potent inhibitor of human immunodeficiency virus.
Antimicrobial agents and chemotherapy 1998;42(2):383-8.
1998: Uckun F M; Sensel M G; Sather H N; Gaynon P S; Arthur D C; Lange B J; Steinherz P G; Kraft P; Hutchinson R; Nachman J B; Reaman G H; Heerema N A
Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(2):527-35.
1998: Dibirdik I; Kristupaitis D; Kurosaki T; Tuel-Ahlgren L; Chu A; Pond D; Tuong D; Luben R; Uckun F M
Stimulation of Src family protein-tyrosine kinases as a proximal and mandatory step for SYK kinase-dependent phospholipase Cgamma2 activation in lymphoma B cells exposed to low energy electromagnetic fields.
The Journal of biological chemistry 1998;273(7):4035-9.
1998: Steinherz P G; Gaynon P S; Breneman J C; Cherlow J M; Grossman N J; Kersey J H; Johnstone H S; Sather H N; Trigg M E; Uckun F M; Bleyer W A
Treatment of patients with acute lymphoblastic leukemia with bulky extramedullary disease and T-cell phenotype or other poor prognostic features: randomized controlled trial from the Children's Cancer Group.
Cancer 1998;82(3):600-12.
1998: Uckun F M; Sensel M G; Sun L; Steinherz P G; Trigg M E; Heerema N A; Sather H N; Reaman G H; Gaynon P S
Biology and treatment of childhood T-lineage acute lymphoblastic leukemia.
Blood 1998;91(3):735-46.
1998: Messinger Y; Yanishevski Y; Ek O; Zeren T; Waurzyniak B; Gunther R; Chelstrom L; Chandan-Langlie M; Schneider E; Myers D E; Evans W; Uckun F M
In vivo toxicity and pharmacokinetic features of B43 (anti-CD19)-genistein immunoconjugate in nonhuman primates.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):165-70.
1997: Perentesis J P; Gunther R; Waurzyniak B; Yanishevski Y; Myers D E; Ek O; Messinger Y; Shao Y; Chelstrom L M; Schneider E; Evans W E; Uckun F M
In vivo biotherapy of HL-60 myeloid leukemia with a genetically engineered recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 1):2217-27.
1997: Uckun F M; Sather H; Gaynon P; Arthur D; Nachman J; Sensel M; Steinherz P; Hutchinson R; Trigg M; Reaman G
Prognostic significance of the CD10+CD19+CD34+ B-progenitor immunophenotype in children with acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Leukemia & lymphoma 1997;27(5-6):445-57.
1997: Gaynon P S; Desai A A; Bostrom B C; Hutchinson R J; Lange B J; Nachman J B; Reaman G H; Sather H N; Steinherz P G; Trigg M E; Tubergen D G; Uckun F M
Early response to therapy and outcome in childhood acute lymphoblastic leukemia: a review.
Cancer 1997;80(9):1717-26.
1997: Myers D E; Jun X; Clementson D; Donelson R; Sicheneder A; Hoffman N; Bell K; Sarquis M; Langlie M C; Turner N; Uckun F M
Large scale manufacturing of TXU(anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate for clinical trials.
Leukemia & lymphoma 1997;27(3-4):275-302.
1997: Uckun F M; Sather H N; Gaynon P S; Arthur D C; Trigg M E; Tubergen D G; Nachman J; Steinherz P G; Sensel M G; Reaman G H
Clinical features and treatment outcome of children with myeloid antigen positive acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Blood 1997;90(1):28-35.
1997: Waurzyniak B; Schneider E A; Tumer N; Yanishevski Y; Gunther R; Chelstrom L M; Wendorf H; Myers D E; Irvin J D; Messinger Y; Ek O; Zeren T; Langlie M C; Evans W E; Uckun F M
In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):881-90.
1997: Gaynon P S; Crotty M L; Sather H N; Bostrom B C; Nachman J B; Steinherz P G; Heerema N A; Sarquis M; Tuel-Ahlgren L; Uckun F M
Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative.
Leukemia & lymphoma 1997;26(1-2):57-65.
1997: Uckun F M; Gaynon P S; Sensel M G; Nachman J; Trigg M E; Steinherz P G; Hutchinson R; Bostrom B C; Sather H N; Reaman G H
Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(6):2214-21.
1997: Uckun F M; Yang Z; Sather H; Steinherz P; Nachman J; Bostrom B; Crotty L; Sarquis M; Ek O; Zeren T; Tubergen D; Reaman G; Gaynon P
Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: a Children's Cancer Group Study.
Blood 1997;89(10):3769-77.
1997: Bendel A E; Shao Y; Davies S M; Warman B; Yang C H; Waddick K G; Uckun F M; Perentesis J P
A recombinant fusion toxin targeted to the granulocyte-macrophage colony-stimulating factor receptor.
Leukemia & lymphoma 1997;25(3-4):257-70.
1997: Perentesis J P; Bendel A E; Shao Y; Warman B; Davies S M; Yang C H; Chandan-Langlie M; Waddick K G; Uckun F M
Granulocyte-macrophage colony-stimulating factor receptor-targeted therapy of chemotherapy- and radiation-resistant human myeloid leukemias.
Leukemia & lymphoma 1997;25(3-4):247-56.
1997: Uckun F M; Gaynon P; Sather H; Arthur D; Trigg M; Tubergen D; Nachman J; Steinherz P; Sensel M G; Reaman G R
Clinical features and treatment outcome of children with biphenotypic CD2+ CD19+ acute lymphoblastic leukemia: a Children's Cancer Group study.
Blood 1997;89(7):2488-93.
1997: Perentesis J P; Waddick K G; Bendel A E; Shao Y; Warman B E; Chandan-Langlie M; Uckun F M
Induction of apoptosis in multidrug-resistant and radiation-resistant acute myeloid leukemia cells by a recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):347-55.
1997: Uckun F M; Yanishevski Y; Tumer N; Waurzyniak B; Messinger Y; Chelstrom L M; Lisowski E A; Ek O; Zeren T; Wendorf H; Langlie M C; Irvin J D; Myers D E; Fuller G B; Evans W; Gunther R
Pharmacokinetic features, immunogenicity, and toxicity of B43(anti-CD19)-pokeweed antiviral protein immunotoxin in cynomolgus monkeys.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):325-37.
1997: Waddick K G; Chandan-Langlie M; Uckun F M
Differential effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on the radiation sensitivity of normal versus leukemic bone marrow progenitor cell populations.
Leukemia & lymphoma 1997;25(1-2):77-90.
1996: Uckun F M; Reaman G; Steinherez P G; Arthur D C; Sather H; Trigg M; Tubergen D; Gaynon P
Improved clinical outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: a Children's Cancer Group Study.
Leukemia & lymphoma 1996;24(1-2):57-70.
1996: Uckun F M; Steinherz P G; Sather H; Trigg M; Arthur D; Tubergen D; Gaynon P; Reaman G
CD2 antigen expression on leukemic cells as a predictor of event-free survival after chemotherapy for T-lineage acute lymphoblastic leukemia: a Children's Cancer Group study.
Blood 1996;88(11):4288-95.
1996: Messinger Y; Yanishevski Y; Avramis V I; Ek O; Chelstrom L M; Gunther R; Myers D E; Irvin J D; Evans W; Uckun F M
Treatment of human B-cell precursor leukemia in SCID mice using a combination of the investigational biotherapeutic agent B43-PAP with cytosine arabinoside.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1533-42.
1996: Messinger Y; Chelstrom L; Gunther R; Uckun F M
Selective homing of human leukemic B-cell precursors to specific lymphohematopoietic microenvironments in SCID mice: a role for the beta 1 integrin family surface adhesion molecules VLA-4 and VLA-5.
Leukemia & lymphoma 1996;23(1-2):61-9.
1996: Xiao J; Biaglow J E; Chae-Park H J; Jin J; Tuel-Ahlgren L; Myers D E; Burkhardt A L; Bolen J B; Uckun F M
Role of hydroxyl radicals in radiation-induced activation of lyn tyrosine kinase in human B-cell precursors.
Leukemia & lymphoma 1996;22(5-6):421-30.
1996: Uckun F M; Waddick K G; Mahajan S; Jun X; Takata M; Bolen J; Kurosaki T
BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells.
Science (New York, N.Y.) 1996;273(5278):1096-100.
1996: Myers D E; Chandan-Langlie M; Chelstrom L M; Uckun F M
In vitro and in vivo anti-leukemic efficacy of cyclic AMP modulating agents against human leukemic B-cell precursors.
Leukemia & lymphoma 1996;22(3-4):259-64.
1996: Gunther R; Chelstrom L M; Wendorf H R; Schneider E A; Covalciuc K; Johnson B; Clementson D; Irvin J D; Myers D E; Uckun F M
Toxicity profile of the investigational new biotherapeutic agent, B43 (anti-CD19)-pokeweed antiviral protein immunotoxin.
Leukemia & lymphoma 1996;22(1-2):61-70, follow.186, color plate II-V.
1996: Xiao J; Messinger Y; Jin J; Myers D E; Bolen J B; Uckun F M
Signal transduction through the beta1 integrin family surface adhesion molecules VLA-4 and VLA-5 of human B-cell precursors activates CD19 receptor-associated protein-tyrosine kinases.
The Journal of biological chemistry 1996;271(13):7659-64.
1996: Uckun F M; Tuel-Ahlgren L; Waddick K G; Jun X; Jin J; Myers D E; Rowley R B; Burkhardt A L; Bolen J B
Physical and functional interactions between Lyn and p34cdc2 kinases in irradiated human B-cell precursors.
The Journal of biological chemistry 1996;271(11):6389-97.
1996: Tuel-Ahlgren L; Jun X; Waddick K G; Jin J; Bolen J; Uckun F M
Role of tyrosine phosphorylation in radiation-induced cell cycle-arrest of leukemic B-cell precursors at the G2-M transition checkpoint.
Leukemia & lymphoma 1996;20(5-6):417-26.
1996: Smith M; Arthur D; Camitta B; Carroll A J; Crist W; Gaynon P; Gelber R; Heerema N; Korn E L; Link M; Murphy S; Pui C H; Pullen J; Reamon G; Sallan S E; Sather H; Shuster J; Simon R; Trigg M; Tubergen D; Uckun F; Ungerleider R
Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(1):18-24.
1995: Waddick K G; Myers D E; Gunther R; Chelstrom L M; Chandan-Langlie M; Irvin J D; Tumer N; Uckun F M
In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation-resistant human B-cell precursor leukemia cells.
Blood 1995;86(11):4228-33.
1995: Uckun F M; Kurosaki T; Jin J; Jun X; Morgan A; Takata M; Bolen J; Luben R
Exposure of B-lineage lymphoid cells to low energy electromagnetic fields stimulates Lyn kinase.
The Journal of biological chemistry 1995;270(46):27666-70.
1995: Myers D E; Jun X; Waddick K G; Forsyth C; Chelstrom L M; Gunther R L; Tumer N E; Bolen J; Uckun F M
Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9575-9.
1995: Waddick K G; Finnegan D M; Chelstrom L M; Uckun F M
In vivo radiosensitizing effects of recombinant interleukin 6 on radiation resistant BCL-1 B-lineage leukemia cells in a murine syngeneic bone marrow transplant model system.
Leukemia & lymphoma 1995;19(1-2):121-8.
1995: Myers D E; Yanishevski Y; Masson E; Irvin J D; Evans W E; Uckun F M
Favorable pharmacodynamic features and superior anti-leukemic activity of B43 (anti-CD19) immunotoxins containing two pokeweed antiviral protein molecules covalently linked to each monoclonal antibody molecule.
Leukemia & lymphoma 1995;18(1-2):93-102.
1995: Myers D E; Uckun F M
An anti-CD72 immunotoxin against therapy-refractory B-lineage acute lymphoblastic leukemia.
Leukemia & lymphoma 1995;18(1-2):119-22.
1995: Uckun F M; Stewart C F; Reaman G; Chelstrom L M; Jin J; Chandan-Langlie M; Waddick K G; White J; Evans W E
In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells.
Blood 1995;85(10):2817-28.
1995: Gunther R; Chelstrom L M; Tuel-Ahlgren L; Simon J; Myers D E; Uckun F M
Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin.
Blood 1995;85(9):2537-45.
1995: Uckun F M; Sather H; Reaman G; Shuster J; Land V; Trigg M; Gunther R; Chelstrom L; Bleyer A; Gaynon P
Leukemic cell growth in SCID mice as a predictor of relapse in high-risk B-lineage acute lymphoblastic leukemia.
Blood 1995;85(4):873-8.
1995: Uckun F M; Evans W E; Forsyth C J; Waddick K G; Ahlgren L T; Chelstrom L M; Burkhardt A; Bolen J; Myers D E
Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.
Science (New York, N.Y.) 1995;267(5199):886-91.
1994: Uckun F M; Downing J R; Chelstrom L M; Gunther R; Ryan M; Simon J; Carroll A J; Tuel-Ahlgren L; Crist W M
Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Blood 1994;84(3):859-65.
1994: Chelstrom L M; Gunther R; Simon J; Raimondi S C; Krance R; Crist W M; Uckun F M
Childhood acute myeloid leukemia in mice with severe combined immunodeficiency.
Blood 1994;84(1):20-6.
1994: Uckun F M; Chandan-Langlie M; Dockham P A; Aeppli D; Sladek N E
Sensitivity of primary clonogenic blasts from acute lymphoblastic leukemia patients to an activated cyclophosphamide, viz., mafosfamide.
Leukemia & lymphoma 1994;13(5-6):417-28.
1994: Weisdorf D J; Woods W G; Nesbit M E; Uckun F; Dusenbery K; Kim T; Haake R; Thomas W; Kersey J H; Ramsay N K
Allogeneic bone marrow transplantation for acute lymphoblastic leukaemia: risk factors and clinical outcome.
British journal of haematology 1994;86(1):62-9.
1993: Waddick K G; Chae H P; Tuel-Ahlgren L; Jarvis L J; Dibirdik I; Myers D E; Uckun F M
Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis.
Radiation research 1993;136(3):313-9.
1993: Uckun F M; Aeppli D; Song C W
Radiation resistance of primary clonogenic blasts from children with acute lymphoblastic leukemia.
International journal of radiation oncology, biology, physics 1993;27(4):899-906.
1993: Uckun F M
Immunotoxins for the treatment of leukaemia.
British journal of haematology 1993;85(3):435-8.
1993: Uckun F M; Kersey J H; Haake R; Weisdorf D; Nesbit M E; Ramsay N K
Pretransplantation burden of leukemic progenitor cells as a predictor of relapse after bone marrow transplantation for acute lymphoblastic leukemia.
The New England journal of medicine 1993;329(18):1296-301.
1993: Uckun F M; Burkhardt A L; Jarvis L; Jun X; Stealey B; Dibirdik I; Myers D E; Tuel-Ahlgren L; Bolen J B
Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny.
The Journal of biological chemistry 1993;268(28):21172-84.
1993: Schieven G L; Kirihara J M; Myers D E; Ledbetter J A; Uckun F M
Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes.
Blood 1993;82(4):1212-20.
1993: Uckun F M; Downing J R; Gunther R; Chelstrom L M; Finnegan D; Land V J; Borowitz M J; Carroll A J; Crist W M
Human t(1;19)(q23;p13) pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Blood 1993;81(11):3052-62.
1993: Waddick K G; Uckun F M
CD5 antigen-positive B lymphocytes in human B cell ontogeny during fetal development and after autologous bone marrow transplantation.
Experimental hematology 1993;21(6):791-8.
1993: Schieven G L; Kirihara J M; Gilliland L K; Uckun F M; Ledbetter J A
Ultraviolet radiation rapidly induces tyrosine phosphorylation and calcium signaling in lymphocytes.
Molecular biology of the cell 1993;4(5):523-30.
1993: Erice A; Balfour H H; Myers D E; Leske V L; Sannerud K J; Kuebelbeck V; Irvin J D; Uckun F M
Anti-human immunodeficiency virus type 1 activity of an anti-CD4 immunoconjugate containing pokeweed antiviral protein.
Antimicrobial agents and chemotherapy 1993;37(4):835-8.
1993: Uckun F M; Myers D E; Irvin J D; Kuebelbeck V M; Finnegan D; Chelstrom L M; Houston L L
Effects of the intermolecular toxin-monoclonal antibody linkage on the in vivo stability, immunogenicity and anti-leukemic activity of B43 (anti-CD19) pokeweed antiviral protein immunotoxin.
Leukemia & lymphoma 1993;9(6):459-76.
1993: Uckun F M; Jaszcz W; Chandan-Langlie M; Waddick K G; Gajl-Peczalska K; Song C W
Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B-cell precursor acute lymphoblastic leukemia.
The Journal of clinical investigation 1993;91(3):1044-51.
1993: Uckun F M; Chandan-Langlie M; Jaszcz W; Obuz V; Waddick K; Song C W
Radiation damage repair capacity of primary clonogenic blasts in acute lymphoblastic leukemia.
Cancer research 1993;53(6):1431-6.
1993: Uckun F M; Song C W
Lack of CD24 antigen expression in B-lineage acute lymphoblastic leukemia is associated with intrinsic radiation resistance of primary clonogenic blasts.
Blood 1993;81(5):1323-32.
1993: Chae H P; Jarvis L J; Uckun F M
Role of tyrosine phosphorylation in radiation-induced activation of c-jun protooncogene in human lymphohematopoietic precursor cells.
Cancer research 1993;53(3):447-51.
1993: Gunther R; Chelstrom L M; Finnegan D; Tuel-Ahlgren L; Irvin J D; Myers D E; Uckun F M
In vivo anti-leukemic efficacy of anti-CD7-pokeweed antiviral protein immunotoxin against human T-lineage acute lymphoblastic leukemia/lymphoma in mice with severe combined immunodeficiency.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(2):298-309.
1993: Jansen B; Kersey J H; Jaszcz W B; Gunther R; Nguyen D P; Chelstrom L M; Tuel-Ahlgren L; Uckun F M
Effective immunochemotherapy of human t(4;11) leukemia in mice with severe combined immunodeficiency (SCID) using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin plus cyclophosphamide.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(2):290-7.
1993: Uckun F M; Schieven G L; Tuel-Ahlgren L M; Dibirdik I; Myers D E; Ledbetter J A; Song C W
Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):252-6.
1993: Uckun F M; Myers D E
Allograft and autograft purging using immunotoxins in clinical bone marrow transplantation for hematologic malignancies.
Journal of hematotherapy 1993;2(2):155-63.
1992: Uckun F M; Tuel-Ahlgren L; Song C W; Waddick K; Myers D E; Kirihara J; Ledbetter J A; Schieven G L
Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9005-9.
1992: Uckun F M; Haissig S; Ledbetter J A; Fidler P; Myers D E; Kuebelbeck V; Weisdorf D; Gajl-Peczalska K; Kersey J H; Ramsay N K
Developmental hierarchy during early human B-cell ontogeny after autologous bone marrow transplantation using autografts depleted of CD19+ B-cell precursors by an anti-CD19 pan-B-cell immunotoxin containing pokeweed antiviral protein.
Blood 1992;79(12):3369-79.
1992: Uckun F M; Chelstrom L M; Finnegan D; Tuel-Ahlgren L; Manivel C; Irvin J D; Myers D E; Gunther R
Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide.
Blood 1992;79(12):3116-29.
1992: Uckun F M; Chelstrom L M; Irvin J D; Finnegan D; Gunther R; Young J; Kuebelbeck V; Myers D E; Houston L L
In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against BCL-1 murine B-cell leukemia.
Blood 1992;79(10):2649-61.
1992: Uckun F M; Manivel C; Arthur D; Chelstrom L M; Finnegan D; Tuel-Ahlgren L; Irvin J D; Myers D E; Gunther R
In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Blood 1992;79(9):2201-14.
1992: Chelstrom L M; Finnegan D; Uckun F M
Treatment of BCL-1 murine B-cell leukemia with recombinant cytokines. Comparative analysis of the anti-leukemic potential of interleukin 1 beta (IL-1 beta), interleukin 2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), and their combination.
Leukemia & lymphoma 1992;7(1-2):79-86.
1992: Uckun F M; Kersey J H; Haake R; Weisdorf D; Ramsay N K
Autologous bone marrow transplantation in high-risk remission B-lineage acute lymphoblastic leukemia using a cocktail of three monoclonal antibodies (BA-1/CD24, BA-2/CD9, and BA-3/CD10) plus complement and 4-hydroperoxycyclophosphamide for ex vivo bone marrow purging.
Blood 1992;79(4):1094-104.
1992: Jansen B; Uckun F M; Jaszcz W B; Kersey J H
Establishment of a human t(4;11) leukemia in severe combined immunodeficient mice and successful treatment using anti-CD19 (B43)-pokeweed antiviral protein immunotoxin.
Cancer research 1992;52(2):406-12.
1992: Kersey J; Weisdorf D; Uckun F; Vallera D; Jansen B; Nesbit M; Haake R; Ramsay N
Allogeneic and autologous bone marrow transplantation for high risk acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6 Suppl 2():191-2.
1992: Uckun F M; Mitchell J B; Obuz V; Chandan-Langlie M; Min W S; Haissig S; Song C W
Radiation and heat sensitivity of human T-lineage acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) clones displaying multiple drug resistance (MDR).
International journal of radiation oncology, biology, physics 1992;23(1):115-25.
1992: Uckun F M; Song C W; Nesbit M; Kersey J H; Ramsay N K
Immunophenotype predicts radiation resistance in T-lineage acute lymphoblastic leukemia and T-lineage non-Hodgkin's lymphoma.
International journal of radiation oncology, biology, physics 1992;24(4):705-12.
1991: Uckun F M; Ramsay N K; Waddick K G; Jaszcz W; Chandan-Langlie M; Obuz V; Haake R; Gajl-Peczalska K; Kersey J H; Song C W
In vitro and in vivo radiation resistance associated with CD3 surface antigen expression in T-lineage acute lymphoblastic leukemia.
Blood 1991;78(11):2945-55.
1991: Uckun F M; Mitchell J B; Obuz V; Park C H; Waddick K; Friedman N; Oubaha L; Min W S; Song C W
Radiation sensitivity of human B-lineage lymphoid precursor cells.
International journal of radiation oncology, biology, physics 1991;21(6):1553-60.
1991: Uckun F M; Schieven G L; Dibirdik I; Chandan-Langlie M; Tuel-Ahlgren L; Ledbetter J A
Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.
The Journal of biological chemistry 1991;266(26):17478-85.
1991: Dibirdik I; Langlie M C; Ledbetter J A; Tuel-Ahlgren L; Obuz V; Waddick K G; Gajl-Peczalska K; Schieven G L; Uckun F M
Engagement of interleukin-7 receptor stimulates tyrosine phosphorylation, phosphoinositide turnover, and clonal proliferation of human T-lineage acute lymphoblastic leukemia cells.
Blood 1991;78(3):564-70.
1991: Uckun F M; Tuel-Ahlgren L; Obuz V; Smith R; Dibirdik I; Hanson M; Langlie M C; Ledbetter J A
Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6323-7.
1991: Waddick K G; Song C W; Souza L; Uckun F M
Comparative analysis of the in vivo radioprotective effects of recombinant granulocyte colony-stimulating factor (G-CSF), recombinant granulocyte-macrophage CSF, and their combination.
Blood 1991;77(11):2364-71.
1991: Uckun F M; Dibirdik I; Smith R; Tuel-Ahlgren L; Chandan-Langlie M; Schieven G L; Waddick K G; Hanson M; Ledbetter J A
Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3589-93.
1991: Gilliland L K; Teh H S; Uckun F M; Norris N A; Teh S J; Schieven G L; Ledbetter J A
CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1759-65.
1991: Myers D E; Irvin J D; Smith R S; Kuebelbeck V M; Uckun F M
Production of a pokeweed antiviral protein (PAP)-containing immunotoxin, B43-PAP, directed against the CD19 human B lineage lymphoid differentiation antigen in highly purified form for human clinical trials.
Journal of immunological methods 1991;136(2):221-37.
1991: Zarling J M; Moran P A; Haffar O; Diegel M; Myers D E; Kuelbeck V; Ledbetter J A; Uckun F M
Inhibition of HIV-1 replication in seropositive patients' CD4+ T-cells by pokeweed antiviral protein-monoclonal antibody conjugates.
International journal of immunopharmacology 1991;13 Suppl 1():63-8.
1990: Uckun F M; Gajl-Peczalska K; Myers D E; Jaszcz W; Haissig S; Ledbetter J A
Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells.
Blood 1990;76(12):2449-56.
1990: Uckun F M
Regulation of human B-cell ontogeny.
Blood 1990;76(10):1908-23.
1990: Uckun F M; Kersey J H; Vallera D A; Ledbetter J A; Weisdorf D; Myers D E; Haake R; Ramsay N K
Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4-hydroperoxycyclophosphamide for marrow purging.
Blood 1990;76(9):1723-33.
1990: Zarling J M; Moran P A; Haffar O; Sias J; Richman D D; Spina C A; Myers D E; Kuebelbeck V; Ledbetter J A; Uckun F M
Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies.
Nature 1990;347(6288):92-5.
1990: Woods W G; Ramsay N K; Weisdorf D J; Haake R; Vallera D A; Kim T H; Lasky L; Nesbit M E; Bostrom B; Uckun F
Bone marrow transplantation for acute lymphocytic leukemia utilizing total body irradiation followed by high doses of cytosine arabinoside: lack of superiority over cyclophosphamide-containing conditioning regimens.
Bone marrow transplantation 1990;6(1):9-16.
1990: Uckun F M; Souza L; Waddick K G; Wick M; Song C W
In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice.
Blood 1990;75(3):638-45.
1990: Min W S; Song C W; Uckun F M
Thermal sensitivity and thermal tolerance of human B-lineage acute lymphoblastic leukemia (ALL) cells.
International journal of radiation oncology, biology, physics 1990;18(1):147-53.
1990: Weisdorf D; Ramsay N; LeBien T; Woods W; Bostrom B; Nesbit M; Vallera D; Uckun F; Goldman A; Kim T
Allogeneic and autologous bone marrow transplantation for acute lymphoblastic leukemia.
Haematology and blood transfusion 1990;33():679-83.
1990: Vallera D A; Uckun F M
Bone marrow purging with immunotoxins for treatment of T cell acute lymphoblastic leukemia (T-ALL).
Progress in clinical and biological research 1990;333():191-204; discussion 205.
1989: Uckun F M; Fauci A S; Chandan-Langlie M; Myers D E; Ambrus J L
Detection and characterization of human high molecular weight B cell growth factor receptors on leukemic B cells in chronic lymphocytic leukemia.
The Journal of clinical investigation 1989;84(5):1595-608.
1989: Uckun F M; Song C W
Radiobiological features of human pluripotent bone marrow progenitor cells (CFU-GEMM).
International journal of radiation oncology, biology, physics 1989;17(5):1021-5.
1989: Uckun F M; Myers D E; Ledbetter J A; Wee S L; Vallera D A
Cell-type-specific cytotoxicity of anti-CD4 and anti-CD8 ricin immunotoxins against human alloreactive T-cell clones.
Blood 1989;74(7):2445-54.
1989: Uckun F M; Myers D E; Fauci A S; Chandan-Langlie M; Ambrus J L
Leukemic B-cell precursors constitutively express functional receptors for human interleukin-1.
Blood 1989;74(2):761-76.
1989: Myers D E; Uckun F M; Swaim S E; Vallera D A
The effects of aromatic and aliphatic maleimide crosslinkers on anti-CD5 ricin immunotoxins.
Journal of immunological methods 1989;121(1):129-42.
1989: Uckun F M; Muraguchi A; Ledbetter J A; Kishimoto T; O'Brien R T; Roloff J S; Gajl-Peczalska K; Provisor A; Koller B
Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues.
Blood 1989;73(4):1000-15.
1989: Ledbetter J A; Norris N A; Grossmann A; Grosmaire L S; June C H; Uckun F M; Cosand W L; Rabinovitch P S
Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface.
Molecular immunology 1989;26(2):137-45.
1989: Uckun F M; Gesner T G; Song C W; Myers D E; Mufson A
Leukemic B-cell precursors express functional receptors for human interleukin-3.
Blood 1989;73(2):533-42.
1989: Uckun F M; Gillis S; Souza L; Song C W
Effects of recombinant growth factors on radiation survival of human bone marrow progenitor cells.
International journal of radiation oncology, biology, physics 1989;16(2):415-35.
1989: Uckun F M; Gajl-Peczalska K J; Provisor A J; Heerema N A
Immunophenotype-karyotype associations in human acute lymphoblastic leukemia.
Blood 1989;73(1):271-80.
1988: Uckun F M; Ledbetter J A
Immunobiologic differences between normal and leukemic human B-cell precursors.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8603-7.
1988: Uckun F M; Song C W
Radiobiological features of fresh leukemic bone marrow progenitor cells in acute lymphoblastic leukemia.
Cancer research 1988;48(20):5788-95.
1988: Myers D E; Uckun F M; Ball E D; Vallera D A
Immunotoxins for ex vivo marrow purging in autologous bone marrow transplantation for acute nonlymphocytic leukemia.
Transplantation 1988;46(2):240-5.
1988: Uckun F M; Jaszcz W; Ambrus J L; Fauci A S; Gajl-Peczalska K; Song C W; Wick M R; Myers D E; Waddick K; Ledbetter J A
Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins.
Blood 1988;71(1):13-29.
1987: Uckun F M; Fauci A S; Heerema N A; Song C W; Mehta S R; Gajl-Peczalska K; Chandan M; Ambrus J L
B-cell growth factor receptor expression and B-cell growth factor response of leukemic B cell precursors and B lineage lymphoid progenitor cells.
Blood 1987;70(4):1020-34.
1987: Uckun F M; Kersey J H; Gajl-Peczalska K J; Heerema N A; Provisor A J; Haag D; Gilchrist G; Song C W; Arthur D C; Roloff J
Heterogeneity of cultured leukemic lymphoid progenitor cells from B cell precursor acute lymphoblastic leukemia (ALL) patients.
The Journal of clinical investigation 1987;80(3):639-46.

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