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Kenji Uéda

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Ming Zhou; Jiaojiao Mi; Kenji Uéda; Shengli Xu; Piu Chan
Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress.
Furong Cheng; Xin Li; Yaohua Li; Guangwei Liu; Kenji Uéda; Chaodong Wang; Tao Wang; Andrius Baskys; Piu Chan; Shun Yu
α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death.
Qi Xuan; Shun Yu; Bo-Yang Zhang; Ming Zhou; Ye-Qing Cui; De-hong Lu; Kenji Uéda; Sheng-Li Xu; Piu Chan
Increased expression of α-synuclein in aged human brain associated with neuromelanin accumulation.

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All Publications

2013: Ming Zhou; Jiaojiao Mi; Kenji Uéda; Shengli Xu; Piu Chan
Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress.
Brain research 2013;1500():19-27.
2011: Furong Cheng; Xin Li; Yaohua Li; Guangwei Liu; Kenji Uéda; Chaodong Wang; Tao Wang; Andrius Baskys; Piu Chan; Shun Yu
α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death.
Journal of neurochemistry 2011;119(4):815-25.
2011: Qi Xuan; Shun Yu; Bo-Yang Zhang; Ming Zhou; Ye-Qing Cui; De-hong Lu; Kenji Uéda; Sheng-Li Xu; Piu Chan
Increased expression of α-synuclein in aged human brain associated with neuromelanin accumulation.
Journal of neural transmission (Vienna, Austria : 1996) 2011;118(11):1575-83.
2011: Juanjuan Yin; Chen Zhang; Piu Chan; Furong Cheng; Junyan Han; Xin Li; Yaohua Li; Guangwei Liu; qiulan ma; Kenji Uéda; Shun Yu
C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells.
Journal of neural transmission (Vienna, Austria : 1996) 2011;118(8):1155-64.
2011: Yao-Hua Li; Kenji Uéda; Hui Yang; Yi-Wen Ye; Shun Yu; Nan Gao; Xin Li; Piu Chan
Alpha-synuclein functions as a negative regulator for expression of tyrosine hydroxylase.
Acta neurologica Belgica 2011;111(2):130-5.
2011: Yuangang Zhu; Chunli Duan; Li Lü; Hua Gao; Chunli Zhao; Shun Yu; Kenji Uéda; Piu Chan; Hui Yang
α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator.
The international journal of biochemistry & cell biology 2011;43(5):732-41.
2011: Bo Wu; Qi Liu; Chunli Duan; Yaohua Li; Shun Yu; Piu Chan; Kenji Uéda; Hui Yang
Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells.
Acta histochemica 2011;113(1):32-5.
2009: Guangwei Liu; Chunyan Zhang; Juanjuan Yin; Xin Li; Furong Cheng; Yaohua Li; Hui Yang; Kenji Uéda; Piu Chan; Shun Yu
alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity.
Neuroscience letters 2009;454(3):187-92.
2008: Ling Zhang; Chunyan Zhang; Yuangang Zhu; Qing Cai; Piu Chan; Kenji Uéda; Shun Yu; Hui Yang
Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody.
Brain research 2008;1244():40-52.
2008: Mitsuru Tashiro; Masaki Kojima; Hiroshi Kihara; Kouki Kasai; Tomoaki Kamiyoshihara; Kenji Uéda; Sakurako Shimotakahara
Characterization of fibrillation process of alpha-synuclein at the initial stage.
Biochemical and biophysical research communications 2008;369(3):910-4.
2007: Tomoaki Kamiyoshihara; Masaki Kojima; Kenji Uéda; Mitsuru Tashiro; Sakurako Shimotakahara
Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis.
Biochemical and biophysical research communications 2007;355(2):398-403.
2007: Shun Yu; Xin Li; G Liu; J Han; Chen Zhang; Y Li; S Xu; C Liu; Y Gao; Hui Yang; Kenji Uéda; Piu Chan
Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody.
Neuroscience 2007;145(2):539-55.
2006: Shengli Xu; Ming Zhou; Shun Yu; Yanning Cai; Alex Zhang; Kenji Uéda; Piu Chan
Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells.
Biochemical and biophysical research communications 2006;342(1):330-5.
2005: Shun Yu; Kenji Uéda; Piu Chan
Alpha-synuclein and dopamine metabolism.
Molecular neurobiology 2005;31(1-3):243-54.
2004: Shun Yu; Xiaohong Zuo; Yaohua Li; Chen Zhang; Ming Zhou; Yu Alex Zhang; Kenji Uéda; Piu Chan
Inhibition of tyrosine hydroxylase expression in alpha-synuclein-transfected dopaminergic neuronal cells.
Neuroscience letters 2004;367(1):34-9.
2004: Muhammad Abdul Alim; qiulan ma; Kazuya Takeda; Takako Aizawa; Mamoru Matsubara; Minako Nakamura; Akiko Asada; Taro Saito; Hiroyuki Kaji; Mitsunobu Yoshii; Shinichi Hisanaga; Kenji Uéda
Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein.
Journal of Alzheimer's disease : JAD 2004;6(4):435-42; discussion 443-9.
2004: Osamu Yokota; Seishi Terada; Hideki Ishizu; Takeshi Ishihara; Hanae Nakashima; Aki Kugo; Kuniaki Tsuchiya; K Ikeda; Toshiyuki Hayabara; Yuko Saito; Shigeo Murayama; Kenji Uéda; Frédéric Checler; Shigetoshi Kuroda
Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia.
Acta neuropathologica 2004;107(5):399-405.
2003: Osamu Yokota; Seishi Terada; Hideki Ishizu; Hiroshi Ujike; Takeshi Ishihara; Masuyuki Namba; Yasuaki Hayashi; Tetsuya Nishinaka; Reiko Namba; Hanae Nakashima; Kenji Uéda; Frédéric Checler; Shigetoshi Kuroda
Variability and heterogeneity in Alzheimer's disease with cotton wool plaques: a clinicopathological study of four autopsy cases.
Acta neuropathologica 2003;106(4):348-56.
2003: qiulan ma; Piu Chan; Mitsunobu Yoshii; Kenji Uéda
Alpha-synuclein aggregation and neurodegenerative diseases.
Journal of Alzheimer's disease : JAD 2003;5(2):139-48.
2003: Teresa Gomez-Isla; Michael C Irizarry; Ami Mariash; Bonnie Cheung; Oscar Soto; Stefanie Schrump; Jesse Sondel; Linda Kotilinek; John Day; Michael A Schwarzschild; Jang-Ho Cha; Kathy Newell; David W Miller; Kenji Uéda; Anne B Young; Bradley T Hyman; Karen K. Hsiao Ashe
Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.
Neurobiology of aging 2003;24(2):245-58.
2003: Seishi Terada; Hideki Ishizu; Osamu Yokota; Kuniaki Tsuchiya; Hanae Nakashima; Takeshi Ishihara; Daisuke Fujita; Kenji Uéda; K Ikeda; Shigetoshi Kuroda
Glial involvement in diffuse Lewy body disease.
Acta neuropathologica 2003;105(2):163-9.
2002: Osamu Yokota; Seishi Terada; Hideki Ishizu; Hiroshi Ujike; Takeshi Ishihara; Hanae Nakashima; Minoru Yasuda; Yoshihiro Kitamura; Kenji Uéda; Frédéric Checler; Shigetoshi Kuroda
NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases.
Acta neuropathologica 2002;104(6):637-48.
2002: Hirotake Uchikado; Eizo Iseki; Kuniaki Tsuchiya; Takashi Togo; Omi Katsuse; Kenji Uéda; Masanori Kato; Kenji Kosaka
Dementia with Lewy bodies showing advanced Lewy pathology but minimal Alzheimer pathology--Lewy pathology causes neuronal loss inducing progressive dementia.
Clinical neuropathology 2002;21(6):269-77.
2002: Osamu Yokota; Seishi Terada; Hideki Ishizu; Kuniaki Tsuchiya; Yoshihiro Kitamura; K Ikeda; Kenji Uéda; Shigetoshi Kuroda
NACP/alpha-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC).
Acta neuropathologica 2002;104(4):333-41.
2002: Eizo Iseki; Noriko Takayama; Yoshiko Furukawa; Wami Marui; Toshiki Nakai; Satoshi Miura; Kenji Uéda; Kenji Kosaka
Immunohistochemical study of synphilin-1 in brains of patients with dementia with Lewy bodies - synphilin-1 is non-specifically implicated in the formation of different neuronal cytoskeletal inclusions.
Neuroscience letters 2002;326(3):211-5.
2002: Wami Marui; Eizo Iseki; Toshiki Nakai; Satoshi Miura; Masanori Kato; Kenji Uéda; Kenji Kosaka
Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies.
Journal of the neurological sciences 2002;195(2):153-9.
2002: Eizo Iseki; Noriko Takayama; Wami Marui; Kenji Uéda; Kenji Kosaka
Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains.
Journal of the neurological sciences 2002;195(1):85-91.
2001: Eizo Iseki; Masanori Kato; Wami Marui; Kenji Uéda; Kenji Kosaka
A neuropathological study of the disturbance of the nigro-amygdaloid connections in brains from patients with dementia with Lewy bodies.
Journal of the neurological sciences 2001;185(2):129-34.
2001: Takashi Togo; Eizo Iseki; Wami Marui; Haruhiko Akiyama; Kenji Uéda; Kenji Kosaka
Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies.
Journal of the neurological sciences 2001;184(1):71-5.
2000: Eizo Iseki; Wami Marui; H Sawada; Kenji Uéda; Kenji Kosaka
Accumulation of human alpha-synuclein in different cytoskeletons in Lewy bodies in brains of dementia with Lewy bodies.
Neuroscience letters 2000;290(1):41-4.
2000: Kunimasa Arima; T Mizutani; Muhammad Abdul Alim; H Tonozuka-Uehara; Yoko Izumiyama; S Hirai; Kenji Uéda
NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies.
Acta neuropathologica 2000;100(2):115-21.
2000: Eizo Iseki; Wami Marui; Haruhiko Akiyama; Kenji Uéda; Kenji Kosaka
Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using alpha-synuclein-immunohistochemistry.
Neuroscience letters 2000;286(1):69-73.
2000: Wami Marui; Eizo Iseki; Kenji Uéda; Kenji Kosaka
Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer's disease.
Journal of the neurological sciences 2000;174(2):81-4.
2000: Fusheng Yang; Kenji Uéda; P Chen; Karen K. Hsiao Ashe; Gregory M. Cole
Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein.
Brain research 2000;853(2):381-3.
1999: Kunimasa Arima; S Hirai; N Sunohara; K Aoto; Yoko Izumiyama; Kenji Uéda; K Ikeda; M Kawai
Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies.
Brain research 1999;843(1-2):53-61.
1999: Eizo Iseki; Wami Marui; Kenji Kosaka; Kenji Uéda
Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease.
Neuroscience letters 1999;265(1):9-12.
1998: Kunimasa Arima; Kenji Uéda; N Sunohara; K Arakawa; S Hirai; Minako Nakamura; H Tonozuka-Uehara; M Kawai
NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy.
Acta neuropathologica 1998;96(5):439-44.
1998: Kunimasa Arima; Kenji Uéda; N Sunohara; S Hirai; Yoko Izumiyama; H Tonozuka-Uehara; M Kawai
Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies.
Brain research 1998;808(1):93-100.