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Kohjiro Ueki

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Jonathon N Winnay; Jeremie Boucher; Marcelo A Mori; Kohjiro Ueki; C Ronald Kahn
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
Anke Assmann; Kohjiro Ueki; Jonathon Winnay; Takahashi Kadowaki; Rohit N Kulkarni
Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.
Cullen M Taniguchi; José O Aleman; Kohjiro Ueki; Ji Luo; Tomoichiro Asano; Hideaki Kaneto; Gregory Stephanopoulos; Lewis C Cantley; C Ronald Kahn
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.

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All Publications

2010: Jonathon N Winnay; Jeremie Boucher; Marcelo A Mori; Kohjiro Ueki; C Ronald Kahn
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
Nature medicine 2010;16(4):438-45.
2009: Anke Assmann; Kohjiro Ueki; Jonathon Winnay; Takahashi Kadowaki; Rohit N Kulkarni
Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.
Molecular and cellular biology 2009;29(11):3219-28.
2007: Cullen M Taniguchi; José O Aleman; Kohjiro Ueki; Ji Luo; Tomoichiro Asano; Hideaki Kaneto; Gregory Stephanopoulos; Lewis C Cantley; C Ronald Kahn
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Molecular and cellular biology 2007;27(8):2830-40.
2006: Cullen M Taniguchi; Thien Tran; Tatsuya Kondo; Ji Luo; Kohjiro Ueki; Lewis C Cantley; C Ronald Kahn
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12093-7.
2006: Kohjiro Ueki; Terumasa Okada; Jiang Hu; Chong Wee Liew; Anke Assmann; Gabriella M Dahlgren; Jennifer L Peters; Jonathan G Shackman; Min Zhang; Isabella Artner; Leslie S Satin; Roland Stein; Martin Holzenberger; Robert T Kennedy ; C Ronald Kahn; Rohit N Kulkarni
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
Nature genetics 2006;38(5):583-8.
2006: Zhiheng He; Darren M Opland; Kerrie J Way; Kohjiro Ueki; Natalya Bodyak; Peter M Kang; Seigo Izumo; Rohit N Kulkarni; Bo Wang; Ronglih Liao; C Ronald Kahn; George L King
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):787-93.
2006: Keiko Naruse; Christian Rask-Madsen; Noriko Takahara; Sung-woo Ha; Kiyoshi Suzuma; Kerrie J Way; Judith R C Jacobs; Allen Clermont; Kohjiro Ueki; Yuzuru Ohshiro; Junqing Zhang; Allison B Goldfine; George L King
Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.
Diabetes 2006;55(3):691-8.
2005: Saskia M Brachmann; Kohjiro Ueki; Jeffrey A Engelman; Ronald C Kahn; Lewis C Cantley
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.
Molecular and cellular biology 2005;25(5):1596-607.
2005: Cullen M Taniguchi; Kohjiro Ueki; Ronald Kahn
Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism.
The Journal of clinical investigation 2005;115(3):718-27.
2004: Vijay K Yechoor; Mary-Elizabeth Patti; Kohjiro Ueki; Palle G Laustsen; Robert Saccone; Ravi Rauniyar; C Ronald Kahn
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16525-30.
2004: Kohjiro Ueki; Tatsuya Kondo; Yu-Hua Tseng; C Ronald Kahn
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10422-7.
2004: Kohjiro Ueki; Tatsuya Kondo; C Ronald Kahn
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Molecular and cellular biology 2004;24(12):5434-46.
2004: Dong Chen; Franck Mauvais-Jarvis; Matthias Blüher; Simon J Fisher; Alison C Jozsi; Laurie J Goodyear; Kohjiro Ueki; C Ronald Kahn
p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.
Molecular and cellular biology 2004;24(1):320-9.
2003: Kohjiro Ueki; David A Fruman; Claudine M Yballe; Mathias Fasshauer; Johannes Klein; Tomoichiro Asano; Lewis C Cantley; C Ronald Kahn
Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
The Journal of biological chemistry 2003;278(48):48453-66.
2003: Zhen Y Jiang; Zhiheng He; Benjamin L King; Tatsuya Kuroki; Darren M Opland; Kiyoshi Suzuma; Izumi Suzuma; Kohjiro Ueki; Rohit N Kulkarni; C Ronald Kahn; George L King
Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
The Journal of biological chemistry 2003;278(34):31964-71.
2002: Palle G Laustsen; M Dodson Michael; Barbara E Crute; Shmuel E Cohen; Kohjiro Ueki; Rohit N Kulkarni; Susanna R Keller; Gustav E Lienhard; C Ronald Kahn
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice.
Genes & development 2002;16(24):3213-22.
2002: Yu-Hua Tseng; Kohjiro Ueki; Kristina M Kriauciunas; C Ronald Kahn
Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin.
The Journal of biological chemistry 2002;277(35):31601-11.
2002: Matthias Blüher; M Dodson Michael; Odile D Peroni; Kohjiro Ueki; Nathan Carter; Barbara B Kahn; C Ronald Kahn
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.
Developmental cell 2002;3(1):25-38.
2002: Kohjiro Ueki; David A Fruman; Saskia M Brachmann; Yu-Hua Tseng; Lewis C Cantley; C Ronald Kahn
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Molecular and cellular biology 2002;22(3):965-77.
2002: Kiyoshi Suzuma; Noriko Takahara; Izumi Suzuma; Keiji Isshiki; Kohjiro Ueki; Michael Leitges; Lloyd Paul Aiello; George L King
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):721-6.
2002: Izumi Suzuma; Kiyoshi Suzuma; Kohjiro Ueki; Yasuaki Hata; Edward P Feener; George L King; Lloyd Paul Aiello
Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways.
The Journal of biological chemistry 2002;277(2):1047-57.
2002: Kohjiro Ueki; Claudine M Yballe; Saskia M Brachmann; David Vicent; John M Watt; C Ronald Kahn; Lewis C Cantley
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):419-24.
2002: Franck Mauvais-Jarvis; Kohjiro Ueki; David A Fruman; Michael F Hirshman; Kei Sakamoto; Laurie J Goodyear; Matteo Iannacone; Domenico Accili; Lewis C Cantley; C Ronald Kahn
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
The Journal of clinical investigation 2002;109(1):141-9.
2001: Mathias Fasshauer; Johannes Klein; Kristina M Kriauciunas; Kohjiro Ueki; M Benito; C Ronald Kahn
Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes.
Molecular and cellular biology 2001;21(1):319-29.
2001: K Tsuruzoe; R Emkey; Kristina M Kriauciunas; Kohjiro Ueki; C Ronald Kahn
Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
Molecular and cellular biology 2001;21(1):26-38.
2000: Kiyoshi Suzuma; Keiko Naruse; Izumi Suzuma; Noriko Takahara; Kohjiro Ueki; Lloyd Paul Aiello; George L King
Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells.
The Journal of biological chemistry 2000;275(52):40725-31.
2000: Kohjiro Ueki; P Algenstaedt; Franck Mauvais-Jarvis; C Ronald Kahn
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.
Molecular and cellular biology 2000;20(21):8035-46.
2000: Michael Ristow; M F Pfister; Andrew J Yee; M Schubert; L Michael; Chen-Yu zhang; Kohjiro Ueki; M Dodson Michael; Bradford B Lowell; C Ronald Kahn
Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12239-43.
2000: Mathias Fasshauer; Johannes Klein; Kohjiro Ueki; Kristina M Kriauciunas; M Benito; Morris F White; C Ronald Kahn
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.
The Journal of biological chemistry 2000;275(33):25494-501.
1999: A Virkamäki; Kohjiro Ueki; C Ronald Kahn
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.
The Journal of clinical investigation 1999;103(7):931-43.