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Karel Ulbrich

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Robert Pola; Irena Sieglová; Karel Ulbrich; Milan Fábry; Martina Kabešová; Marek Kovář; Vlastimil Král; Richard Laga; Michal Pechar
Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia.
Eliézer Jäger; Blanka Ríhová; Petr Stěpánek; Petr Chytil; Tomás Etrych; Fernando Carlos Giacomelli; Alessandro Jäger; Karel Ulbrich
Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester.
Sijumon Kunjachan; Tomás Etrych; Felix Gremse; Fabian Kiessling; Patrick Koczera; Michal Pechar; Robert Pola; Gert Storm; Benjamin Theek; Karel Ulbrich; Twan Lammers
Noninvasive optical imaging of nanomedicine biodistribution.

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All Publications

2013: Robert Pola; Irena Sieglová; Karel Ulbrich; Milan Fábry; Martina Kabešová; Marek Kovář; Vlastimil Král; Richard Laga; Michal Pechar
Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia.
Biomacromolecules 2013;14(3):881-9.
2013: Eliézer Jäger; Blanka Ríhová; Petr Stěpánek; Petr Chytil; Tomás Etrych; Fernando Carlos Giacomelli; Alessandro Jäger; Karel Ulbrich
Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester.
Journal of controlled release : official journal of the Controlled Release Society 2013;165(2):153-61.
2013: Sijumon Kunjachan; Tomás Etrych; Felix Gremse; Fabian Kiessling; Patrick Koczera; Michal Pechar; Robert Pola; Gert Storm; Benjamin Theek; Karel Ulbrich; Twan Lammers
Noninvasive optical imaging of nanomedicine biodistribution.
ACS nano 2013;7(1):252-62.
2012: Tomás Etrych; Blanka Ríhová; Milada Sírová; Jirí Strohalm; Vladimir Subr; Karel Ulbrich
HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity.
Journal of controlled release : official journal of the Controlled Release Society 2012;164(3):346-54.
2012: Martin Studenovsky; Karel Ulbrich; Tomás Etrych; Martina Kabesova; Lubomir Kovar; Michal Pechar; Robert Pola; Blanka Rihova
Polymer carriers for anticancer drugs targeted to EGF receptor.
Macromolecular bioscience 2012;12(12):1714-20.
2012: Sergey K Filippov; Petr V Konarev; Christinem Papadakis; Josef Plestil; Petr Stepanek; Petr Chytil; Margarita Dyakonova; Tomás Etrych; Karel Ulbrich; Alexander Zhigunov; Dmitri I Svergun
Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system.
Biomacromolecules 2012;13(8):2594-604.
2012: Richard Laga; Mark Tangney; Karel Ulbrich; Robert Carlisle; Len W Seymour
Polymer coatings for delivery of nucleic acid therapeutics.
Journal of controlled release : official journal of the Controlled Release Society 2012;161(2):537-53.
2012: Ondřej Sedláček; Martin Studenovský; Jan Svoboda; Martin Hrubý; Dana Kaňková; Jan Kovář; David Větvička; Karel Ulbrich
Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation.
Bioorganic & medicinal chemistry 2012;20(13):4056-63.
2011: Blanka Říhová; Milada Šírová; Tomás Etrych; Jakub Tomala; Karel Ulbrich; Marek Kovář
Synergistic effect of EMF-BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma.
Journal of drug targeting 2011;19(10):890-9.
2011: Tomás Etrych; Jirí Strohalm; Petr Chytil; B Říhová; Karel Ulbrich
Novel star HPMA-based polymer conjugates for passive targeting to solid tumors.
Journal of drug targeting 2011;19(10):874-89.
2011: Jakub Tomala; Karel Ulbrich; Helena Chmelova; Blanka Rihova; Milada Sirova; Jirí Strohalm; Marek Kovar
Antitumor activity of IL-2/anti-IL-2 mAb immunocomplexes exerts synergism with that of N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugate due to its low immunosuppressive activity.
International journal of cancer. Journal international du cancer 2011;129(8):2002-12.
2011: Michal Pechar; Robert Pola; Irena Sieglová; Karel Ulbrich; Lucie Bednárová; Milan Fábry; Vlastimil Král; Richard Laga; Petr Maloň; Ondřej Vaněk
Coiled coil peptides as universal linkers for the attachment of recombinant proteins to polymer therapeutics.
Biomacromolecules 2011;12(10):3645-55.
2011: Tomás Etrych; Lubomír Kovář; Blanka Ríhová; Jirí Strohalm; Petr Chytil; Karel Ulbrich
Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy.
Journal of controlled release : official journal of the Controlled Release Society 2011;154(3):241-8.
2011: Martin Strohalm; Karel Ulbrich; Michael Volný; Filip Kaftan; Lukáš Krásný; Petr Novák; Jirí Strohalm; Vladimír Havlíček
Poly[N-(2-hydroxypropyl)methacrylamide]-based tissue-embedding medium compatible with MALDI mass spectrometry imaging experiments.
Analytical chemistry 2011;83(13):5458-62.
2011: Ondrej Sedlacek; Martin Studenovsky; David Vetvicka; Martin Hruby; Lubomir Kovar; Jan Kucka; Blanka Rihova; Karel Ulbrich
Ellipticine-aimed polymer-conjugated auger electron emitter: multistage organelle targeting approach.
Bioconjugate chemistry 2011;22(6):1194-201.
2011: Tomás Etrych; Jirí Strohalm; Petr Chytil; Peter Černoch; Larisa Starovoytova; Michal Pechar; Karel Ulbrich
Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;42(5):527-39.
2011: Houria Bachtarzi; Mark Stevenson; Vladimir Šubr; Karel Ulbrich; Leonard W Seymour; Kerry D Fisher
Targeting adenovirus gene delivery to activated tumour-associated vasculature via endothelial selectins.
Journal of controlled release : official journal of the Controlled Release Society 2011;150(2):196-203.
2011: Libor Kostka; Cestmír Konák; Vladimir Subr; Milena Spírková; Yoseph Addadi; Michal Neeman; Twan Lammers; Karel Ulbrich
Removable nanocoatings for siRNA polyplexes.
Bioconjugate chemistry 2011;22(2):169-79.
2011: M Studenovsky; Karel Ulbrich; M Ibrahimova; Blanka Rihova
Polymer conjugates of the highly potent cytostatic drug 2-pyrrolinodoxorubicin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;42(1-2):156-63.
2010: Martin Hruby; Sergey K Filippov; Jiri Panek; Michaela Novakova; Hana Mackova; Jan Kucka; Karel Ulbrich
Thermoresponsive micelles for radionuclide delivery.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e60-2.
2010: Petr Chytil; Tomás Etrych; Jaroslav Kříž; Vladimir Subr; Karel Ulbrich
N-(2-Hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2010;41(3-4):473-82.
2010: Ondrej Hovorka; Vladimir Subr; David Větvička; Lubomír Kovář; Jirí Strohalm; Martin Strohalm; Aleš Benda; Martin Hof; Karel Ulbrich; Blanka Ríhová
Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2010;76(3):514-24.
2010: Martin Hruby; Sergey K Filippov; Jiri Panek; Michaela Novakova; Hana Mackova; Jan Kucka; David Vetvicka; Karel Ulbrich
Polyoxazoline thermoresponsive micelles as radionuclide delivery systems.
Macromolecular bioscience 2010;10(8):916-24.
2010: Blanka Ríhová; Tomás Etrych; Milada Sírová; Lubomír Kovár; Ondrej Hovorka; Marek Kovár; A Benda; Karel Ulbrich
Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through an amide or hydrazone bond.
Molecular pharmaceutics 2010;7(4):1027-40.
2010: Tomás Etrych; Milada Sírová; L Starovoytova; Blanka Ríhová; Karel Ulbrich
HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release.
Molecular pharmaceutics 2010;7(4):1015-26.
2010: Lubomir Kovar; Tomás Etrych; Martina Kabesova; Vladimir Subr; David Vetvicka; Ondrej Hovorka; Jirí Strohalm; Jan Sklenar; Petr Chytil; Karel Ulbrich; Blanka Rihova
Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2010;31(4):233-42.
2010: Karel Ulbrich; Vladimir Subr
Structural and chemical aspects of HPMA copolymers as drug carriers.
Advanced drug delivery reviews 2010;62(2):150-66.
2010: Richard Laga; Cestmír Konák; Vladimir Subr; Karel Ulbrich; Nisaraporn Suthiwangcharoen; Zhongwei Niu; Qian Wang
Chemical conjugation of cowpea mosaic viruses with reactive HPMA-based polymers.
Journal of biomaterials science. Polymer edition 2010;21(12):1669-85.
2010: Milada Sirova; Tomas Mrkvan; Tomás Etrych; Petr Chytil; Pavel Rossmann; Marketa Ibrahimova; Lubomir Kovar; Karel Ulbrich; Blanka Rihova
Preclinical evaluation of linear HPMA-doxorubicin conjugates with pH-sensitive drug release: efficacy, safety, and immunomodulating activity in murine model.
Pharmaceutical research 2010;27(1):200-8.
2009: Robert Pola; Martin Studenovský; Michal Pechar; Karel Ulbrich; Ondrej Hovorka; David Vetvicka; Blanka Ríhová
HPMA-copolymer conjugates targeted to tumor endothelium using synthetic oligopeptides.
Journal of drug targeting 2009;17(10):763-76.
2009: Tomás Etrych; Jirí Strohalm; Lubomír Kovár; Martina Kabesová; Blanka Ríhová; Karel Ulbrich
HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(1):18-26.
2009: Bedrich Porsch; Richard Laga; Jirí Horský; Cestmír Konák; Karel Ulbrich
Molecular weight and polydispersity of calf-thymus DNA: static light-scattering and size-exclusion chromatography with dual detection.
Biomacromolecules 2009;10(11):3148-50.
2009: David Vetvicka; Martin Hruby; Ondrej Hovorka; Tomás Etrych; Miroslav Vetrik; Lubomir Kovar; Marek Kovar; Karel Ulbrich; Blanka Rihova
Biological evaluation of polymeric micelles with covalently bound doxorubicin.
Bioconjugate chemistry 2009;20(11):2090-7.
2009: Martin Hruby; Cestmir Konak; Jan Kucka; Miroslav Vetrik; Sergey K Filippov; David Vetvicka; Hana Mackova; Goran Karlsson; Katarina Edwards; Blanka Rihova; Karel Ulbrich
Thermoresponsive, hydrolytically degradable polymer micelles intended for radionuclide delivery.
Macromolecular bioscience 2009;9(10):1016-27.
2009: Twan Lammers; Vladimir Subr; Karel Ulbrich; Peter Peschke; Peter E Huber; Wim E Hennink; Gert Storm
Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers.
Biomaterials 2009;30(20):3466-75.
2009: Hana Krakovicová; Tomás Etrych; Karel Ulbrich
HPMA-based polymer conjugates with drug combination.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;37(3-4):405-12.
2009: Robert C Carlisle; Ying Di; Anna M Cerny; Andreas F-P Sonnen; Robert B Sim; Nicola K Green; Vladimir Subr; Karel Ulbrich; Robert J C Gilbert; Kerry D Fisher; Robert W Finberg; Leonard W Seymour
Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.
Blood 2009;113(9):1909-18.
2008: Tomás Etrych; Petr Chytil; Tomás Mrkvan; Milada Sírová; Blanka Ríhová; Karel Ulbrich
Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting.
Journal of controlled release : official journal of the Controlled Release Society 2008;132(3):184-92.
2008: Marek Kovar; Jakub Tomala; Helena Chmelova; Lubomir Kovar; Tomas Mrkvan; Radka Joskova; Zuzana Zakostelska; Tomas Etrych; Jiri Strohalm; Karel Ulbrich; Milada Sirova; Blanka Rihova
Overcoming immunoescape mechanisms of BCL1 leukemia and induction of CD8+ T-cell-mediated BCL1-specific resistance in mice cured by targeted polymer-bound doxorubicin.
Cancer research 2008;68(23):9875-83.
2008: T Lammers; Vladimir Subr; P Peschke; Rainer Kühnlein; Wim E Hennink; Karel Ulbrich; F Kiessling; Melanie Heilmann; Jürgen Debus; P E Huber; Gert Storm
Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy.
British journal of cancer 2008;99(6):900-10.
2008: Cestmír Konák; Vladimír Subr; Libor Kostka; Petr Stepánek; Karel Ulbrich; Helmut Schlaad
Coating of vesicles with hydrophilic reactive polymers.
Langmuir : the ACS journal of surfaces and colloids 2008;24(14):7092-8.
2008: Petr Chytil; Tomás Etrych; Cestmír Konák; Milada Sírová; Tomás Mrkvan; J Boucek; Blanka Ríhová; Karel Ulbrich
New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting.
Journal of controlled release : official journal of the Controlled Release Society 2008;127(2):121-30.
2008: Robert C Carlisle; Reuben Benjamin; Simon S Briggs; Stephanie Sumner-Jones; Jenny McIntosh; Deborah Gill; Steve Hyde; Amit Nathwani; Vladimir Subr; Karel Ulbrich; Leonard W Seymour; Kerry D Fisher
Coating of adeno-associated virus with reactive polymers can ablate virus tropism, enable retargeting and provide resistance to neutralising antisera.
The journal of gene medicine 2008;10(4):400-11.
2008: Nicola K Green; Joanne Morrison; Sarah Hale; Simon S Briggs; Mark Stevenson; Vladimir Subr; Karel Ulbrich; Lois Chandler; Vivien Mautner; Leonard W Seymour; Kerry D Fisher
Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer.
The journal of gene medicine 2008;10(3):280-9.
2008: Joanne Morrison; Simon S Briggs; Nicola Green; Kerry Fisher; Vladimir Subr; Karel Ulbrich; Sean Kehoe; Leonard W Seymour
Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):244-51.
2007: Tomás Etrych; Tomás Mrkvan; Blanka Ríhová; Karel Ulbrich
Star-shaped immunoglobulin-containing HPMA-based conjugates with doxorubicin for cancer therapy.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(1):31-8.
2007: Kerry D Fisher; Nicola K Green; Ashley Hale; Vladimir Subr; Karel Ulbrich; Leonard W Seymour
Passive tumour targeting of polymer-coated adenovirus for cancer gene therapy.
Journal of drug targeting 2007;15(7-8):546-51.
2007: Martin Hruby; Jan Kucka; Ondrej Lebeda; Hana Mackova; Michal Babic; Cestmir Konak; Martin Studenovsky; Antonin Sikora; Ján Kozempel; Karel Ulbrich
New bioerodable thermoresponsive polymers for possible radiotherapeutic applications.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(1):25-33.
2007: Lubomír Kovár; Jirí Strohalm; Petr Chytil; Tomás Mrkvan; Marek Kovár; Ondrej Hovorka; Karel Ulbrich; Blanka Ríhová
The same drug but a different mechanism of action: comparison of free doxorubicin with two different N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugates in EL-4 cancer cell line.
Bioconjugate chemistry 2007;18(3):894-902.
2007: Mark Stevenson; Ashley Hale; Sarah J M Hale; Nicola K Green; G Black; Kerry D Fisher; Karel Ulbrich; A Fabra; Leonard W Seymour
Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via alpha6-integrins.
Cancer gene therapy 2007;14(4):335-45.
2007: Twan Lammers; Peter Peschke; Rainer Kühnlein; Vladimir Subr; Karel Ulbrich; Jürgen Debus; Peter Huber; Wim E Hennink; Gert Storm
Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(3):333-41.
2007: Milada Sirova; Jirí Strohalm; Vladimir Subr; Daniela Plocova; Pavel Rossmann; Tomás Mrkvan; Karel Ulbrich; Blanka Rihova
Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice.
Cancer immunology, immunotherapy : CII 2007;56(1):35-47.
2006: Michal Pechar; A Braunová; Karel Ulbrich; Markéta Jelínková; B Øíhová; L Seymour
Hydrolytically and reductively degradable carriers of biologically active molecules based on multiblock polymers of poly(ethylene glycol).
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e8-10.
2006: Karel Ulbrich; R Laga; Vladimir Subr
Reactive polymers for modification of biologically active molecules and gene delivery vectors.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e3-5.
2006: Robert C Carlisle; Simon S Briggs; Ashley Hale; Nicola K Green; Kerry D Fisher; Tomás Etrych; Karel Ulbrich; Vivien Mautner; Leonard W Seymour
Use of synthetic vectors for neutralising antibody resistant delivery of replicating adenovirus DNA.
Gene therapy 2006;13(22):1579-86.
2006: Twan Lammers; Peter Peschke; Rainer Kühnlein; Vladimir Subr; Karel Ulbrich; Peter Huber; Wim E Hennink; Gert Storm
Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer-based drug delivery systems.
Neoplasia (New York, N.Y.) 2006;8(10):788-95.
2006: Petr Chytil; Tomás Etrych; Cestmír Konák; Milada Sírová; Tomás Mrkvan; Blanka Ríhová; Karel Ulbrich
Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(1):26-36.
2006: Ondrej Hovorka; Tomás Etrych; Vladimir Subr; Jirí Strohalm; Karel Ulbrich; Blanka Ríhová
HPMA based macromolecular therapeutics: internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition.
Journal of drug targeting 2006;14(6):391-403.
2006: Mark Stevenson; E Boos; C Herbert; Ashley Hale; N Green; M Lyons; L Chandler; Karel Ulbrich; N van Rooijen; Vivien Mautner; K Fisher; L Seymour
Chick embryo lethal orphan virus can be polymer-coated and retargeted to infect mammalian cells.
Gene therapy 2006;13(4):356-68.
2006: Fabian Kiessling; Melanie Heilmann; Twan Lammers; Karel Ulbrich; Vladimir Subr; Peter Peschke; Bjoern Waengler; Walter Mier; Hans-Hermann Schrenk; Michael Bock; Lothar R Schad; Wolfhard Semmler
Synthesis and characterization of HE-24.8: a polymeric contrast agent for magnetic resonance angiography.
Bioconjugate chemistry 2006;17(1):42-51.
2006: Vladimir Subr; Cestmír Konák; Richard Laga; Karel Ulbrich
Coating of DNA/poly(L-lysine) complexes by covalent attachment of poly[N-(2-hydroxypropyl)methacrylamide].
Biomacromolecules 2006;7(1):122-30.
2005: Twan Lammers; Rainer Kühnlein; Maria Kissel; Vladimir Subr; Tomás Etrych; Robert Pola; Michal Pechar; Karel Ulbrich; Gert Storm; Peter Huber; Peter Peschke
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):103-18.
2005: Tomás Mrkvan; Milada Sirova; Tomás Etrych; Petr Chytil; Jirí Strohalm; Dana Plocova; Karel Ulbrich; Blanka Rihova
Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):119-29.
2005: Blanka Rihova; Jirí Strohalm; M Kovar; Tomás Mrkvan; Vladimir Subr; Ondrej Hovorka; Milada Sirova; L Rozprimova; K Kubackova; Karel Ulbrich
Induction of systemic antitumour resistance with targeted polymers.
Scandinavian journal of immunology 2005;62 Suppl 1():100-5.
2005: Martin Hrubý; Cestmír Konák; Karel Ulbrich
Polymeric micellar pH-sensitive drug delivery system for doxorubicin.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(1):137-48.
2005: Michal Pechar; Karel Ulbrich; Tomás Etrych; A Fabra; M Stevenson; L Seymour
Oligopeptides as targeting structures in cancer theraPY.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):376-9.
2004: Marek Kovár; Lubomír Kovár; Vladimir Subr; Tomás Etrych; Karel Ulbrich; Tomás Mrkvan; J Loucká; Blanka Ríhová
HPMA copolymers containing doxorubicin bound by a proteolytically or hydrolytically cleavable bond: comparison of biological properties in vitro.
Journal of controlled release : official journal of the Controlled Release Society 2004;99(2):301-14.
2004: Nicola K Green; C W Herbert; Sarah J M Hale; Ashley Hale; Vivien Mautner; R Harkins; Terry W Hermiston; Karel Ulbrich; Kerry D Fisher; Leonard W Seymour
Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus.
Gene therapy 2004;11(16):1256-63.
2004: Karel Ulbrich; Tomás Etrych; Petr Chytil; Michal Pechar; M Jelinkova; Blanka Rihova
Polymeric anticancer drugs with pH-controlled activation.
International journal of pharmaceutics 2004;277(1-2):63-72.
2004: Karel Ulbrich; Vladimir Subr
Polymeric anticancer drugs with pH-controlled activation.
Advanced drug delivery reviews 2004;56(7):1023-50.
2004: Robert C Carlisle; Tomás Etrych; Simon S Briggs; Jon A Preece; Karel Ulbrich; Leonard W Seymour
Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction.
The journal of gene medicine 2004;6(3):337-44.
2004: Pavla Poucková; Marie Zadinová; Daniela Hlousková; Jirí Strohalm; Dana Plocová; M Spunda; tomás olejár; M Zitko; Josef Matousek; Karel Ulbrich; Josef Soucek
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(1):83-92.
2004: Karel Ulbrich; Tomás Etrych; Petr Chytil; Markéta Jelínková; Blanka Ríhová
Antibody-targeted polymer-doxorubicin conjugates with pH-controlled activation.
Journal of drug targeting 2004;12(8):477-89.
2003: Marek Kovár; Tomás Mrkvan; Jirí Strohalm; Tomás Etrych; Karel Ulbrich; M Stastný; Blanka Ríhová
HPMA copolymer-bound doxorubicin targeted to tumor-specific antigen of BCL1 mouse B cell leukemia.
Journal of controlled release : official journal of the Controlled Release Society 2003;92(3):315-30.
2003: Markéta Jelínková; Jirí Strohalm; Tomás Etrych; Karel Ulbrich; Blanka Ríhová
Starlike vs. classic macromolecular prodrugs: two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs.
Pharmaceutical research 2003;20(10):1558-64.
2003: Blanka Ríhová; Jirí Strohalm; Jana Prausová; Katerina Kubácková; Markéta Jelínková; Ladka Rozprimová; Milada Sírová; Dana Plocová; Tomás Etrych; Vladimir Subr; Tomás Mrkvan; Marek Kovár; Karel Ulbrich
Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(1-2):1-16.
2003: Karel Ulbrich; Tomás Etrych; Petr Chytil; Markéta Jelínková; Blanka Ríhová
HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):33-47.
2003: Leonard W Seymour; Kerry D Fisher; Nicola K Green; Sarah J M Hale; M Lyons; Vivien Mautner; Shibani Nicum; David Onion; David Oupický; Mark Stevenson; Karel Ulbrich
Adenovirus retargeting and systemic delivery.
Ernst Schering Research Foundation workshop 2003;(43):107-14.
2003: Blanka Ríhová; Jirí Strohalm; Katerina Kubácková; Markéta Jelínková; Ladka Rozprimová; Milada Sírová; Dana Plocová; Tomás Mrkvan; Marek Kovár; Jindriska Pokorná; Tomás Etrych; Karel Ulbrich
Drug-HPMA-HuIg conjugates effective against human solid cancer.
Advances in experimental medicine and biology 2003;519():125-43.
2002: Christopher M Ward; Michal Pechar; David Oupický; Karel Ulbrich; Leonard W Seymour
Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo.
The journal of gene medicine 2002;4(5):536-47.
2002: Maria Kissel; Peter Peschke; Vladimir Subr; Karel Ulbrich; Anke M Strunz; Rainer Kühnlein; Jürgen Debus; Eckhard Friedrich
Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA.
European journal of nuclear medicine and molecular imaging 2002;29(8):1055-62.
2002: Tomás Reschel; Cestmír Konák; David Oupický; Leonard W Seymour; Karel Ulbrich
Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):201-17.
2002: Marek St'astný; Dana Plocová; Tomás Etrych; Marek Kovár; Karel Ulbrich; Blanka Ríhová
HPMA-hydrogels containing cytostatic drugs. Kinetics of the drug release and in vivo efficacy.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):101-11.
2002: Josef Soucek; Pavla Poucková; Jirí Strohalm; Dana Plocová; Daniela Hlousková; Marie Zadinová; Karel Ulbrich
Poly[N-(2-hydroxypropyl)methacrylamide] conjugates of bovine pancreatic ribonuclease (RNase A) inhibit growth of human melanoma in nude mice.
Journal of drug targeting 2002;10(3):175-83.
2002: Ondrej Hovorka; Marek St'astný; Tomás Etrych; Vladimir Subr; Jirí Strohalm; Karel Ulbrich; Blanka Ríhová
Differences in the intracellular fate of free and polymer-bound doxorubicin.
Journal of controlled release : official journal of the Controlled Release Society 2002;80(1-3):101-17.
2002: David Oupický; Manfred Ogris; Kenneth A Howard; Philip R Dash; Karel Ulbrich; Leonard W Seymour
Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):463-72.
2002: Marek Kovár; Jirí Strohalm; Tomás Etrych; Karel Ulbrich; Blanka Ríhová
Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect.
Bioconjugate chemistry 2002;13(2):206-15.
2002: Marek St'astný; Dana Plocová; Tomás Etrych; Karel Ulbrich; Blanka Ríhová
HPMA-hydrogels result in prolonged delivery of anticancer drugs and are a promising tool for the treatment of sensitive and multidrug resistant leukaemia.
European journal of cancer (Oxford, England : 1990) 2002;38(4):602-8.
2002: Marek Kovár; Jirí Strohalm; Karel Ulbrich; Blanka Ríhová
In vitro and in vivo effect of HPMA copolymer-bound doxorubicin targeted to transferrin receptor of B-cell lymphoma 38C13.
Journal of drug targeting 2002;10(1):23-30.
2002: Blanka Ríhová; Jirí Strohalm; Katerina Kubácková; Markéta Jelínková; Ondrej Hovorka; Marek Kovár; Dana Plocová; Milada Sírová; Marek St'astný; Ladka Rozprimová; Karel Ulbrich
Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs.
Journal of controlled release : official journal of the Controlled Release Society 2002;78(1-3):97-114.
2001: Blanka Ríhová; Tomás Etrych; Michal Pechar; Markéta Jelínková; M Stastný; Ondrej Hovorka; Marek Kovár; Karel Ulbrich
Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):225-32.
2001: Tomás Etrych; Markéta Jelínková; Blanka Ríhová; Karel Ulbrich
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties.
Journal of controlled release : official journal of the Controlled Release Society 2001;73(1):89-102.
2001: Maria Kissel; Peter Peschke; Vladimir Subr; Karel Ulbrich; Jochen Schuhmacher; Jürgen Debus; Eckhard Friedrich
Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.
PDA journal of pharmaceutical science and technology / PDA 2001;55(3):191-201.
2001: Kerry D Fisher; Y Stallwood; Nicola K Green; Karel Ulbrich; Vivien Mautner; Leonard W Seymour
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies.
Gene therapy 2001;8(5):341-8.
2001: Josef Soucek; Pavla Poucková; Marie Zadinová; Daniela Hlousková; Dana Plocová; Jirí Strohalm; Zbynek Hrkal; T Oleár; Karel Ulbrich
Polymer conjugated bovine seminal ribonuclease inhibits growth of solid tumors and development of metastases in mice.
Neoplasma 2001;48(2):127-32.
2001: S Prokopová-Kubinová; Lydia Vargová; L Tao; Karel Ulbrich; Vladimir Subr; Eva Syková; C Nicholson
Poly[N-(2-hydroxypropyl)methacrylamide] polymers diffuse in brain extracellular space with same tortuosity as small molecules.
Biophysical journal 2001;80(1):542-8.
2000: Blanka Ríhová; Markéta Jelínková; Jirí Strohalm; Marek St'astný; Ondrej Hovorka; Dana Plocová; Marek Kovár; L Dráberová; Karel Ulbrich
Antiproliferative effect of a lectin- and anti-Thy-1.2 antibody-targeted HPMA copolymer-bound doxorubicin on primary and metastatic human colorectal carcinoma and on human colorectal carcinoma transfected with the mouse Thy-1.2 gene.
Bioconjugate chemistry 2000;11(5):664-73.
2000: Kerry D Fisher; Karel Ulbrich; Vladimir Subr; C M Ward; Vivien Mautner; D Blakey; Leonard W Seymour
A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression.
Gene therapy 2000;7(15):1337-43.
2000: Kenneth A Howard; Philip R Dash; Martin L Read; K Ward; L M Tomkins; O Nazarova; Karel Ulbrich; Leonard W Seymour
Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA.
Biochimica et biophysica acta 2000;1475(3):245-55.
2000: David Oupický; Kenneth A Howard; Cestmír Konák; Philip R Dash; Karel Ulbrich; Leonard W Seymour
Steric stabilization of poly-L-Lysine/DNA complexes by the covalent attachment of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide].
Bioconjugate chemistry 2000;11(4):492-501.
2000: Martin L Read; Philip R Dash; A Clark; Kenneth A Howard; David Oupický; Veska Toncheva; H Oya Alpar; Etienne Schacht; Karel Ulbrich; Leonard W Seymour
Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic-hydrophilic copolymers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(3):169-77.
2000: Michal Pechar; Karel Ulbrich; Vladimir Subr; Leonard W Seymour; E H Schacht
Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin.
Bioconjugate chemistry 2000;11(2):131-9.
2000: David Oupický; Cestmír Konák; Karel Ulbrich; MA Wolfert; Leonard W Seymour
DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers.
Journal of controlled release : official journal of the Controlled Release Society 2000;65(1-2):149-71.
2000: Blanka Ríhová; Markéta Jelínková; Jirí Strohalm; Vladimir Subr; Dana Plocová; Ondrej Hovorka; M Novák; D Plundrová; Y Germano; Karel Ulbrich
Polymeric drugs based on conjugates of synthetic and natural macromolecules. II. Anti-cancer activity of antibody or (Fab')(2)-targeted conjugates and combined therapy with immunomodulators.
Journal of controlled release : official journal of the Controlled Release Society 2000;64(1-3):241-61.
2000: Karel Ulbrich; Vladimir Subr; Jirí Strohalm; Dana Plocová; Markéta Jelínková; Blanka Ríhová
Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation.
Journal of controlled release : official journal of the Controlled Release Society 2000;64(1-3):63-79.
2000: Philip R Dash; Martin L Read; Kerry D Fisher; Kenneth A Howard; MA Wolfert; David Oupický; Vladimir Subr; Jirí Strohalm; Karel Ulbrich; Leonard W Seymour
Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin.
The Journal of biological chemistry 2000;275(6):3793-802.
1999: Martin L Read; Tomás Etrych; Karel Ulbrich; Leonard W Seymour
Characterisation of the binding interaction between poly(L-lysine) and DNA using the fluorescamine assay in the preparation of non-viral gene delivery vectors.
FEBS letters 1999;461(1-2):96-100.
1999: MA Wolfert; Philip R Dash; O Nazarova; David Oupický; Leonard W Seymour; S Smart; Jirí Strohalm; Karel Ulbrich
Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.
Bioconjugate chemistry 1999;10(6):993-1004.
1999: David Oupický; Cestmír Konák; Philip R Dash; Leonard W Seymour; Karel Ulbrich
Effect of albumin and polyanion on the structure of DNA complexes with polycation containing hydrophilic nonionic block.
Bioconjugate chemistry 1999;10(5):764-72.
1999: Marek St'astný; Jirí Strohalm; Dana Plocová; Karel Ulbrich; Blanka Ríhová
A possibility to overcome P-glycoprotein (PGP)-mediated multidrug resistance by antibody-targeted drugs conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier.
European journal of cancer (Oxford, England : 1990) 1999;35(3):459-66.
1999: David Oupický; Cestmír Konák; Karel Ulbrich
DNA complexes with block and graft copolymers of N-(2-hydroxypropyl)methacrylamide and 2-(trimethylammonio)ethyl methacrylate.
Journal of biomaterials science. Polymer edition 1999;10(5):573-90.
1998: Blanka Ríhová; J Trohalm; Markéta Jelínková; M Stastný; Ondrej Hovorka; Dana Plocová; Vladimir Subr; Karel Ulbrich
[Use of targeted drugs in antineoplastic and immunosuppressive therapy].
Bratislavské lekárske listy 1998;99(8-9):439-46.
1998: Veska Toncheva; MA Wolfert; Philip R Dash; David Oupický; Karel Ulbrich; Leonard W Seymour; Etienne Schacht
Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.
Biochimica et biophysica acta 1998;1380(3):354-68.
1998: Markéta Jelínková; Jirí Strohalm; Dana Plocová; Vladimir Subr; Marek St'astný; Karel Ulbrich; Blanka Ríhová
Targeting of human and mouse T-lymphocytes by monoclonal antibody-HPMA copolymer-doxorubicin conjugates directed against different T-cell surface antigens.
Journal of controlled release : official journal of the Controlled Release Society 1998;52(3):253-70.
1997: Blanka Ríhová; J Srogl; Markéta Jelínková; Ondrej Hovorka; M Buresová; Vladimir Subr; Karel Ulbrich
HPMA-based biodegradable hydrogels containing different forms of doxorubicin. Antitumor effects and biocompatibility.
Annals of the New York Academy of Sciences 1997;831():57-71.
1997: Karel Ulbrich; Michal Pechar; Jirí Strohalm; Vladimir Subr; Blanka Ríhová
Synthesis of biodegradable polymers for controlled drug release.
Annals of the New York Academy of Sciences 1997;831():47-56.
1997: Marek St'astný; Karel Ulbrich; Jirí Strohalm; Pavel Rossmann; Blanka Ríhová
Abnormal differentiation of thymocytes induced by free cyclosporine is avoided when cyclosporine bound to N-(2-hydroxypropyl)methacrylamide copolymer carrier is used.
Transplantation 1997;63(12):1818-27.
1997: V Chytrý; Milos Netopilík; M Bohdanecký; Karel Ulbrich
Phase transition parameters of potential thermosensitive drug release systems based on polymers of N-alkylmethacrylamides.
Journal of biomaterials science. Polymer edition 1997;8(11):817-24.
1997: Pavel Rossmann; Blanka Ríhová; Jirí Strohalm; Karel Ulbrich
Morphology of rat kidney and thymus after native and antibody-coupled cyclosporin A application (reduced toxicity of targeted drug).
Folia microbiologica 1997;42(3):277-87.
1996: MA Wolfert; E H Schacht; V Toncheva; Karel Ulbrich; O Nazarova; Leonard W Seymour
Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers.
Human gene therapy 1996;7(17):2123-33.
1996: M V Pimm; Alan C Perkins; Jirí Strohalm; Karel Ulbrich; Ruth Duncan
Gamma scintigraphy of a 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate containing galactosamine following intravenous administration to nude mice bearing hepatic human colon carcinoma.
Journal of drug targeting 1996;3(5):385-90.
1996: M V Pimm; Alan C Perkins; Jirí Strohalm; Karel Ulbrich; Ruth Duncan
Gamma scintigraphy of the biodistribution of 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in mice with transplanted melanoma and mammary carcinoma.
Journal of drug targeting 1996;3(5):375-83.
1995: Leonard W Seymour; Y Miyamoto; H Maeda; M Brereton; Jirí Strohalm; Karel Ulbrich; Ruth Duncan
Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):766-70.
1995: S Woerly; G Laroche; R Marchand; J Pato; Vladimir Subr; Karel Ulbrich
Intracerebral implantation of hydrogel-coupled adhesion peptides: tissue reaction.
Journal of neural transplantation & plasticity 1995;5(4):245-55.
1994: Leonard W Seymour; Karel Ulbrich; Peter S Steyger; M Brereton; Vladimir Subr; Jirí Strohalm; Ruth Duncan
Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma.
British journal of cancer 1994;70(4):636-41.
1994: H R Yen; S Oscarsson; Karel Ulbrich; Jindrich Kopecek
Adsorption and activation of zymogens at solid-liquid interfaces. I. Chymotrypsinogen on alkylamino modified silica derivatives.
Journal of biomedical materials research 1994;28(2):247-57.
1993: S Woerly; G Maghami; Ruth Duncan; Vladimir Subr; Karel Ulbrich
Synthetic polymer derivatives as substrata for neuronal adhesion and growth.
Brain research bulletin 1993;30(3-4):423-32.
1993: K B O'Hare; Ruth Duncan; Jirí Strohalm; Karel Ulbrich; P Kopeckova
Polymeric drug-carriers containing doxorubicin and melanocyte-stimulating hormone: in vitro and in vivo evaluation against murine melanoma.
Journal of drug targeting 1993;1(3):217-29.
1993: M V Pimm; Alan C Perkins; Ruth Duncan; Karel Ulbrich
Targeting of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate to the hepatocyte galactose-receptor in mice: visualisation and quantification by gamma scintigraphy as a basis for clinical targeting studies.
Journal of drug targeting 1993;1(2):125-31.
1991: Leonard W Seymour; Karel Ulbrich; S R Wedge; I C Hume; Jirí Strohalm; Ruth Duncan
N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice.
British journal of cancer 1991;63(6):859-66.
1991: T K Yeung; John W Hopewell; R H Simmonds; Leonard W Seymour; Ruth Duncan; O Bellini; M Grandi; F Spreafico; Jirí Strohalm; Karel Ulbrich
Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat.
Cancer chemotherapy and pharmacology 1991;29(2):105-11.
1991: Leonard W Seymour; P A Flanagan; A al-Shamkhani; Vladimir Subr; Karel Ulbrich; J Cassidy; Ruth Duncan
Synthetic polymers conjugated to monoclonal antibodies: vehicles for tumour-targeted drug delivery.
Selective cancer therapeutics 1991;7(2):59-73.
1990: Leonard W Seymour; Karel Ulbrich; Jirí Strohalm; Jindrich Kopecek; Ruth Duncan
The pharmacokinetics of polymer-bound adriamycin.
Biochemical pharmacology 1990;39(6):1125-31.
1989: B Rihova; Martin Bilej; V Vetvicka; Karel Ulbrich; Jirí Strohalm; Jindrich Kopecek; Ruth Duncan
Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro.
Biomaterials 1989;10(5):335-42.
1984: B Rihová; Jindrich Kopecek; Karel Ulbrich; M Pospisil; P Mancal
Effect of the chemical structure of N-(2-hydroxypropyl)methacrylamide copolymers on their ability to induce antibody formation in inbred strains of mice.
Biomaterials 1984;5(3):143-8.
1983: Blanka Ríhová; Karel Ulbrich; Jindrich Kopecek; P Mancal
Immunogenicity of N-(2-hydroxypropyl)-methacrylamide copolymers--potential hapten or drug carriers.
Folia microbiologica 1983;28(3):217-27.
1983: M V Solovskij; Karel Ulbrich; Jindrich Kopecek
Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity.
Biomaterials 1983;4(1):44-8.
1982: Karel Ulbrich; Jirí Strohalm; Jindrich Kopecek
Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin.
Biomaterials 1982;3(3):150-4.
1980: Karel Ulbrich; E I Zacharieva; B Obereigner; Jindrich Kopecek
Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain.
Biomaterials 1980;1(4):199-204.