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Karel Ulbrich

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Co-Publications
Name
37
Strohalm, Jirí
36
Subr, Vladimir
33
Ríhová, Blanka
32
Seymour, Leonard
27
Etrych, Tomás
15
Jelínková, Markéta
14
Plocová, Dana
12
Mrkvan, Tomás
12
Duncan, Ruth
11
Fisher, Kerry
11
Konák, Cestmír
11
Kovár, Marek
11
Hovorka, Ondrej
9
Pechar, Michal
8
Kopecek, Jindrich

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Publications

TOP 3
Pola Robert; Studenovský Martin; Pechar Michal; Ulbrich Karel; Hovorka Ondrej; Vetvicka David; Ríhová Blanka
HPMA-copolymer conjugates targeted to tumor endothelium using synthetic oligopeptides.
Porsch Bedrich; Laga Richard; Horský Jirí; Konák Cestmír; Ulbrich Karel
Molecular weight and polydispersity of calf-thymus DNA: static light-scattering and size-exclusion chromatography with dual detection.
Etrych Tomás; Strohalm Jirí; Kovár Lubomír; Kabesová Martina; Ríhová Blanka; Ulbrich Karel
HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity.

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All Publications

2009: Pola Robert; Studenovský Martin; Pechar Michal; Ulbrich Karel; Hovorka Ondrej; Vetvicka David; Ríhová Blanka
HPMA-copolymer conjugates targeted to tumor endothelium using synthetic oligopeptides.
Journal of drug targeting 2009;17(10):773-86.
2009: Porsch Bedrich; Laga Richard; Horský Jirí; Konák Cestmír; Ulbrich Karel
Molecular weight and polydispersity of calf-thymus DNA: static light-scattering and size-exclusion chromatography with dual detection.
Biomacromolecules 2009;10(11):3148-50.
2009: Etrych Tomás; Strohalm Jirí; Kovár Lubomír; Kabesová Martina; Ríhová Blanka; Ulbrich Karel
HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(1):18-26.
2009: Hruby Martin; Konak Cestmir; Kucka Jan; Vetrik Miroslav; Filippov Sergey K; Vetvicka David; Mackova Hana; Karlsson Goran; Edwards Katarina; Rihova Blanka; Ulbrich Karel
Thermoresponsive, hydrolytically degradable polymer micelles intended for radionuclide delivery.
Macromolecular bioscience 2009;9(10):1016-27.
2009: Lammers Twan; Subr Vladimir; Ulbrich Karel; Peschke Peter; Huber Peter E; Hennink Wim E; Storm Gert
Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers.
Biomaterials 2009;30(20):3466-75.
2009: Krakovicová Hana; Etrych Tomás; Ulbrich Karel
HPMA-based polymer conjugates with drug combination.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;37(3-4):405-12.
2009: Carlisle Robert C; Di Ying; Cerny Anna M; Sonnen Andreas F-P; Sim Robert B; Green Nicola K; Subr Vladimir; Ulbrich Karel; Gilbert Robert J C; Fisher Kerry D; Finberg Robert W; Seymour Leonard W
Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.
Blood 2009;113(9):1909-18.
2008: Kovar Marek; Tomala Jakub; Chmelova Helena; Kovar Lubomir; Mrkvan Tomas; Joskova Radka; Zakostelska Zuzana; Etrych Tomas; Strohalm Jiri; Ulbrich Karel; Sirova Milada; Rihova Blanka
Overcoming immunoescape mechanisms of BCL1 leukemia and induction of CD8+ T-cell-mediated BCL1-specific resistance in mice cured by targeted polymer-bound doxorubicin.
Cancer research 2008;68(23):9875-83.
2008: Etrych Tomás; Chytil Petr; Mrkvan Tomás; Sírová Milada; Ríhová Blanka; Ulbrich Karel
Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting.
Journal of controlled release : official journal of the Controlled Release Society 2008;132(3):184-92.
2008: Lammers T; Subr V; Peschke P; Kühnlein R; Hennink W E; Ulbrich K; Kiessling F; Heilmann M; Debus J; Huber P E; Storm G
Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy.
British journal of cancer 2008;99(6):900-10.
2008: Konák Cestmír; Subr Vladimír; Kostka Libor; Stepánek Petr; Ulbrich Karel; Schlaad Helmut
Coating of vesicles with hydrophilic reactive polymers.
Langmuir : the ACS journal of surfaces and colloids 2008;24(14):7092-8.
2008: Chytil P; Etrych T; Konák C; Sírová M; Mrkvan T; Boucek J; Ríhová B; Ulbrich K
New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting.
Journal of controlled release : official journal of the Controlled Release Society 2008;127(2):121-30.
2008: Carlisle Robert C; Benjamin Reuben; Briggs Simon S; Sumner-Jones Stephanie; McIntosh Jenny; Gill Deborah; Hyde Steve; Nathwani Amit; Subr Vladimir; Ulbrich Karel; Seymour Leonard W; Fisher Kerry D
Coating of adeno-associated virus with reactive polymers can ablate virus tropism, enable retargeting and provide resistance to neutralising antisera.
The journal of gene medicine 2008;10(4):400-11.
2008: Green Nicola K; Morrison Joanne; Hale Sarah; Briggs Simon S; Stevenson Mark; Subr Vladimir; Ulbrich Karel; Chandler Lois; Mautner Vivien; Seymour Leonard W; Fisher Kerry D
Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer.
The journal of gene medicine 2008;10(3):280-9.
2008: Morrison Joanne; Briggs Simon S; Green Nicola; Fisher Kerry; Subr Vladimir; Ulbrich Karel; Kehoe Sean; Seymour Leonard W
Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):244-51.
2007: Etrych Tomás; Mrkvan Tomás; Ríhová Blanka; Ulbrich Karel
Star-shaped immunoglobulin-containing HPMA-based conjugates with doxorubicin for cancer therapy.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(1):31-8.
2007: Fisher Kerry D; Green Nicola K; Hale Ashley; Subr Vladimir; Ulbrich Karel; Seymour Leonard W
Passive tumour targeting of polymer-coated adenovirus for cancer gene therapy.
Journal of drug targeting 2007;15(7-8):546-51.
2007: Kovár Lubomír; Strohalm Jirí; Chytil Petr; Mrkvan Tomás; Kovár Marek; Hovorka Ondrej; Ulbrich Karel; Ríhová Blanka
The same drug but a different mechanism of action: comparison of free doxorubicin with two different N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugates in EL-4 cancer cell line.
Bioconjugate chemistry 2007;18(3):894-902.
2007: Hruby Martin; Kucka Jan; Lebeda Ondrej; Mackova Hana; Babic Michal; Konak Cestmir; Studenovsky Martin; Sikora Antonin; Kozempel Jan; Ulbrich Karel
New bioerodable thermoresponsive polymers for possible radiotherapeutic applications.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(1):25-33.
2007: Stevenson M; Hale A B H; Hale S J; Green N K; Black G; Fisher K D; Ulbrich K; Fabra A; Seymour L W
Incorporation of a laminin-derived peptide (SIKVAV) on polymer-modified adenovirus permits tumor-specific targeting via alpha6-integrins.
Cancer gene therapy 2007;14(4):335-45.
2007: Lammers Twan; Peschke Peter; Kühnlein Rainer; Subr Vladimir; Ulbrich Karel; Debus Jürgen; Huber Peter; Hennink Wim; Storm Gert
Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems.
Journal of controlled release : official journal of the Controlled Release Society 2007;117(3):333-41.
2007: Sirova Milada; Strohalm Jiri; Subr Vladimir; Plocova Daniela; Rossmann Pavel; Mrkvan Tomas; Ulbrich Karel; Rihova Blanka
Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice.
Cancer immunology, immunotherapy : CII 2007;56(1):35-47.
2006: Pechar M; Braunová A; Ulbrich K; Jelínková M; Øíhová B; Seymour L
Hydrolytically and reductively degradable carriers of biologically active molecules based on multiblock polymers of poly(ethylene glycol).
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e8-10.
2006: Ulbrich K; Laga R; Subr V
Reactive polymers for modification of biologically active molecules and gene delivery vectors.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e3-5.
2006: Carlisle R C; Briggs S S; Hale A B; Green N K; Fisher K D; Etrych T; Ulbrich K; Mautner V; Seymour L W
Use of synthetic vectors for neutralising antibody resistant delivery of replicating adenovirus DNA.
Gene therapy 2006;13(22):1579-86.
2006: Lammers Twan; Peschke Peter; Kühnlein Rainer; Subr Vladimir; Ulbrich Karel; Huber Peter; Hennink Wim; Storm Gert
Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer-based drug delivery systems.
Neoplasia (New York, N.Y.) 2006;8(10):788-95.
2006: Chytil Petr; Etrych Tomás; Konák Cestmír; Sírová Milada; Mrkvan Tomás; Ríhová Blanka; Ulbrich Karel
Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(1):26-36.
2006: Hovorka Ondrej; Etrych Tomás; Subr Vladimír; Strohalm Jirí; Ulbrich Karel; Ríhová Blanka
HPMA based macromolecular therapeutics: internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition.
Journal of drug targeting 2006;14(6):391-403.
2006: Stevenson M; Boos E; Herbert C; Hale A; Green N; Lyons M; Chandler L; Ulbrich K; van Rooijen N; Mautner V; Fisher K; Seymour L
Chick embryo lethal orphan virus can be polymer-coated and retargeted to infect mammalian cells.
Gene therapy 2006;13(4):356-68.
2006: Kiessling Fabian; Heilmann Melanie; Lammers Twan; Ulbrich Karel; Subr Vladimir; Peschke Peter; Waengler Bjoern; Mier Walter; Schrenk Hans-Herrmann; Bock Michael; Schad Lothar; Semmler Wolfhard
Synthesis and characterization of HE-24.8: a polymeric contrast agent for magnetic resonance angiography.
Bioconjugate chemistry 2006;17(1):42-51.
2006: Subr Vladimír; Konák Cestmír; Laga Richard; Ulbrich Karel
Coating of DNA/poly(L-lysine) complexes by covalent attachment of poly[N-(2-hydroxypropyl)methacrylamide].
Biomacromolecules 2006;7(1):122-30.
2005: Lammers Twan; Kühnlein Rainer; Kissel Maria; Subr Vladimir; Etrych Tomas; Pola Robert; Pechar Michal; Ulbrich Karel; Storm Gert; Huber Peter; Peschke Peter
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):103-18.
2005: Mrkvan Tomas; Sirova Milada; Etrych Tomas; Chytil Petr; Strohalm Jiri; Plocova Dana; Ulbrich Karel; Rihova Blanka
Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):119-29.
2005: Rihova B; Strohalm J; Kovar M; Mrkvan T; Subr V; Hovorka O; Sirova M; Rozprimova L; Kubackova K; Ulbrich K
Induction of systemic antitumour resistance with targeted polymers.
Scandinavian journal of immunology 2005;62 Suppl 1():100-5.
2005: Hrubý Martin; Konák Cestmír; Ulbrich Karel
Polymeric micellar pH-sensitive drug delivery system for doxorubicin.
Journal of controlled release : official journal of the Controlled Release Society 2005;103(1):137-48.
2005: Pechar M; Ulbrich K; Etrych T; Fabra A; Stevenson M; Seymour L
Oligopeptides as targeting structures in cancer theraPY.
Journal of controlled release : official journal of the Controlled Release Society 2005;101(1-3):376-9.
2004: Kovár M; Kovár L; Subr V; Etrych T; Ulbrich K; Mrkvan T; Loucká J; Ríhová B
HPMA copolymers containing doxorubicin bound by a proteolytically or hydrolytically cleavable bond: comparison of biological properties in vitro.
Journal of controlled release : official journal of the Controlled Release Society 2004;99(2):301-14.
2004: Green N K; Herbert C W; Hale S J; Hale A B; Mautner V; Harkins R; Hermiston T; Ulbrich K; Fisher K D; Seymour L W
Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus.
Gene therapy 2004;11(16):1256-63.
2004: Ulbrich K; Etrych T; Chytil P; Pechar M; Jelinkova M; Rihova B
Polymeric anticancer drugs with pH-controlled activation.
International journal of pharmaceutics 2004;277(1-2):63-72.
2004: Ulbrich Karel; Subr Vladimír
Polymeric anticancer drugs with pH-controlled activation.
Advanced drug delivery reviews 2004;56(7):1023-50.
2004: Carlisle Robert C; Etrych Tomas; Briggs Simon S; Preece Jon A; Ulbrich Karel; Seymour Leonard W
Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction.
The journal of gene medicine 2004;6(3):337-44.
2004: Poucková P; Zadinová M; Hlousková D; Strohalm J; Plocová D; Spunda M; Olejár T; Zitko M; Matousek J; Ulbrich K; Soucek J
Polymer-conjugated bovine pancreatic and seminal ribonucleases inhibit growth of human tumors in nude mice.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(1):83-92.
2004: Ulbrich K; Etrych T; Chytil P; Jelínková M; Ríhová B
Antibody-targeted polymer-doxorubicin conjugates with pH-controlled activation.
Journal of drug targeting 2004;12(8):477-89.
2003: Jelínková Markéta; Strohalm Jirí; Etrych Tomás; Ulbrich Karel; Ríhová Blanka
Starlike vs. classic macromolecular prodrugs: two different antibody-targeted HPMA copolymers of doxorubicin studied in vitro and in vivo as potential anticancer drugs.
Pharmaceutical research 2003;20(10):1558-64.
2003: Kovár M; Mrkvan T; Strohalm J; Etrych T; Ulbrich K; Stastný M; Ríhová B
HPMA copolymer-bound doxorubicin targeted to tumor-specific antigen of BCL1 mouse B cell leukemia.
Journal of controlled release : official journal of the Controlled Release Society 2003;92(3):315-30.
2003: Ríhová Blanka; Strohalm Jirí; Prausová Jana; Kubácková Katerina; Jelínková Markéta; Rozprimová Lad'ka; Sírová Milada; Plocová Dana; Etrych Tomás; Subr Vladimír; Mrkvan Tomás; Kovár Marek; Ulbrich Karel
Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data.
Journal of controlled release : official journal of the Controlled Release Society 2003;91(1-2):1-16.
2003: Ulbrich K; Etrych T; Chytil P; Jelínková M; Ríhová B
HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):33-47.
2003: Seymour L W; Fisher K D; Green N K; Hale S J; Lyons M; Mautner V; Nicum S; Onion D; Oupicky D; Stevenson M; Ulbrich K
Adenovirus retargeting and systemic delivery.
Ernst Schering Research Foundation workshop 2003;(43):107-14.
2003: Ríhová Blanka; Strohalm Jirí; Kubácková Katerina; Jelínková Markéta; Rozprimová Ladka; Sírová Milada; Plocová Dana; Mrkvan Tomás; Kovár Marek; Pokorná Jindriska; Etrych Tomás; Ulbrich Karel
Drug-HPMA-HuIg conjugates effective against human solid cancer.
Advances in experimental medicine and biology 2003;519():125-43.
2002: Ward Christopher M; Pechar Michal; Oupicky David; Ulbrich Karel; Seymour Leonard W
Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo.
The journal of gene medicine 2002;4(5):536-47.
2002: Kissel Maria; Peschke Peter; Subr Vladimir; Ulbrich Karel; Strunz Anke M; Kühnlein Rainer; Debus Jürgen; Friedrich Eckhard
Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA.
European journal of nuclear medicine and molecular imaging 2002;29(8):1055-62.
2002: Soucek J; Poucková P; Strohalm J; Plocová D; Hlousková D; Zadinová M; Ulbrich K
Poly[N-(2-hydroxypropyl)methacrylamide] conjugates of bovine pancreatic ribonuclease (RNase A) inhibit growth of human melanoma in nude mice.
Journal of drug targeting 2002;10(3):175-83.
2002: Reschel Tomás; Konák Cestmír; Oupický David; Seymour Leonard W; Ulbrich Karel
Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):201-17.
2002: St'astný Marek; Plocová Dana; Etrych Tomás; Kovár Marek; Ulbrich Karel; Ríhová Blanka
HPMA-hydrogels containing cytostatic drugs. Kinetics of the drug release and in vivo efficacy.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):101-11.
2002: Oupicky David; Ogris Manfred; Howard Kenneth A; Dash Philip R; Ulbrich Karel; Seymour Leonard W
Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):463-72.
2002: Hovorka Ondrej; St'astný M; Etrych T; Subr V; Strohalm J; Ulbrich K; Ríhová B
Differences in the intracellular fate of free and polymer-bound doxorubicin.
Journal of controlled release : official journal of the Controlled Release Society 2002;80(1-3):101-17.
2002: Kovár Marek; Strohalm Jirí; Etrych Tomás; Ulbrich Karel; Ríhová Blanka
Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect.
Bioconjugate chemistry 2002;13(2):206-15.
2002: St'astný M; Plocová D; Etrych T; Ulbrich K; Ríhová B
HPMA-hydrogels result in prolonged delivery of anticancer drugs and are a promising tool for the treatment of sensitive and multidrug resistant leukaemia.
European journal of cancer (Oxford, England : 1990) 2002;38(4):602-8.
2002: Kovár M; Strohalm J; Ulbrich K; Ríhová B
In vitro and in vivo effect of HPMA copolymer-bound doxorubicin targeted to transferrin receptor of B-cell lymphoma 38C13.
Journal of drug targeting 2002;10(1):23-30.
2002: Ríhová B; Strohalm J; Kubácková K; Jelínková M; Hovorka O; Kovár M; Plocová D; Sírová M; St'astný M; Rozprimová L; Ulbrich K
Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs.
Journal of controlled release : official journal of the Controlled Release Society 2002;78(1-3):97-114.
2001: Ríhová B; Etrych T; Pechar M; Jelínková M; Stastný M; Hovorka O; Kovár M; Ulbrich K
Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):225-32.
2001: Kissel M; Peschke P; Subr V; Ulbrich K; Schuhmacher J; Debus J; Friedrich E
Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.
PDA journal of pharmaceutical science and technology / PDA 2001;55(3):191-201.
2001: Etrych T; Jelínková M; Ríhová B; Ulbrich K
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties.
Journal of controlled release : official journal of the Controlled Release Society 2001;73(1):89-102.
2001: Fisher K D; Stallwood Y; Green N K; Ulbrich K; Mautner V; Seymour L W
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies.
Gene therapy 2001;8(5):341-8.
2001: Prokopová-Kubinová S; Vargová L; Tao L; Ulbrich K; Subr V; Syková E; Nicholson C
Poly[N-(2-hydroxypropyl)methacrylamide] polymers diffuse in brain extracellular space with same tortuosity as small molecules.
Biophysical journal 2001;80(1):542-8.
2001: Soucek J; Poucková P; Zadinová M; Hlousková D; Plocová D; Strohalm J; Hrkal Z; Oleár T; Ulbrich K
Polymer conjugated bovine seminal ribonuclease inhibits growth of solid tumors and development of metastases in mice.
Neoplasma 2001;48(2):127-32.
2000: Ríhová B; Jelínková M; Strohalm J; St'astný M; Hovorka O; Plocová D; Kovár M; Dráberová L; Ulbrich K
Antiproliferative effect of a lectin- and anti-Thy-1.2 antibody-targeted HPMA copolymer-bound doxorubicin on primary and metastatic human colorectal carcinoma and on human colorectal carcinoma transfected with the mouse Thy-1.2 gene.
Bioconjugate chemistry 2000;11(5):664-73.
2000: Fisher K D; Ulbrich K; Subr V; Ward C M; Mautner V; Blakey D; Seymour L W
A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression.
Gene therapy 2000;7(15):1337-43.
2000: Howard K A; Dash P R; Read M L; Ward K; Tomkins L M; Nazarova O; Ulbrich K; Seymour L W
Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA.
Biochimica et biophysica acta 2000;1475(3):245-55.
2000: Oupický D; Howard K A; Konák C; Dash P R; Ulbrich K; Seymour L W
Steric stabilization of poly-L-Lysine/DNA complexes by the covalent attachment of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide].
Bioconjugate chemistry 2000;11(4):492-501.
2000: Read M L; Dash P R; Clark A; Howard K A; Oupicky D; Toncheva V; Alpar H O; Schacht E H; Ulbrich K; Seymour L W
Physicochemical and biological characterisation of an antisense oligonucleotide targeted against the bcl-2 mRNA complexed with cationic-hydrophilic copolymers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(3):169-77.
2000: Pechar M; Ulbrich K; Subr V; Seymour L W; Schacht E H
Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin.
Bioconjugate chemistry 2000;11(2):131-9.
2000: Oupický D; Konák C; Ulbrich K; Wolfert M A; Seymour L W
DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers.
Journal of controlled release : official journal of the Controlled Release Society 2000;65(1-2):149-71.
2000: Dash P R; Read M L; Fisher K D; Howard K A; Wolfert M; Oupicky D; Subr V; Strohalm J; Ulbrich K; Seymour L W
Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin.
The Journal of biological chemistry 2000;275(6):3793-802.
2000: Ríhová B; Jelínková M; Strohalm J; Subr V; Plocová D; Hovorka O; Novák M; Plundrová D; Germano Y; Ulbrich K
Polymeric drugs based on conjugates of synthetic and natural macromolecules. II. Anti-cancer activity of antibody or (Fab')(2)-targeted conjugates and combined therapy with immunomodulators.
Journal of controlled release : official journal of the Controlled Release Society 2000;64(1-3):241-61.
2000: Ulbrich K; Subr V; Strohalm J; Plocová D; Jelínková M; Ríhová B
Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation.
Journal of controlled release : official journal of the Controlled Release Society 2000;64(1-3):63-79.
1999: Wolfert M A; Dash P R; Nazarova O; Oupicky D; Seymour L W; Smart S; Strohalm J; Ulbrich K
Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.
Bioconjugate chemistry 1999;10(6):993-1004.
1999: Read M L; Etrych T; Ulbrich K; Seymour L W
Characterisation of the binding interaction between poly(L-lysine) and DNA using the fluorescamine assay in the preparation of non-viral gene delivery vectors.
FEBS letters 1999;461(1-2):96-100.
1999: Oupický D; Konák C; Dash P R; Seymour L W; Ulbrich K
Effect of albumin and polyanion on the structure of DNA complexes with polycation containing hydrophilic nonionic block.
Bioconjugate chemistry 1999;10(5):764-72.
1999: St'astný M; Strohalm J; Plocová D; Ulbrich K; Ríhová B
A possibility to overcome P-glycoprotein (PGP)-mediated multidrug resistance by antibody-targeted drugs conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier.
European journal of cancer (Oxford, England : 1990) 1999;35(3):459-66.
1999: Oupický D; Konák C; Ulbrich K
DNA complexes with block and graft copolymers of N-(2-hydroxypropyl)methacrylamide and 2-(trimethylammonio)ethyl methacrylate.
Journal of biomaterials science. Polymer edition 1999;10(5):573-90.
1998: Ríhová B; Trohalm J; Jelínková M; Stastný M; Hovorka O; Plocová D; Subr V; Ulbrich K
[Use of targeted drugs in antineoplastic and immunosuppressive therapy]
Bratislavské lekárske listy 1998;99(8-9):439-46.
1998: Toncheva V; Wolfert M A; Dash P R; Oupicky D; Ulbrich K; Seymour L W; Schacht E H
Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.
Biochimica et biophysica acta 1998;1380(3):354-68.
1998: Jelínková M; Strohalm J; Plocová D; Subr V; St'astný M; Ulbrich K; Ríhová B
Targeting of human and mouse T-lymphocytes by monoclonal antibody-HPMA copolymer-doxorubicin conjugates directed against different T-cell surface antigens.
Journal of controlled release : official journal of the Controlled Release Society 1998;52(3):253-70.
1997: Ríhová B; Srogl J; Jelínková M; Hovorka O; Buresová M; Subr V; Ulbrich K
HPMA-based biodegradable hydrogels containing different forms of doxorubicin. Antitumor effects and biocompatibility.
Annals of the New York Academy of Sciences 1997;831():57-71.
1997: Ulbrich K; Pechar M; Strohalm J; Subr V; Ríhová B
Synthesis of biodegradable polymers for controlled drug release.
Annals of the New York Academy of Sciences 1997;831():47-56.
1997: St'astný M; Ulbrich K; Strohalm J; Rossmann P; Ríhová B
Abnormal differentiation of thymocytes induced by free cyclosporine is avoided when cyclosporine bound to N-(2-hydroxypropyl)methacrylamide copolymer carrier is used.
Transplantation 1997;63(12):1818-27.
1997: Chytrý V; Netopilík M; Bohdanecký M; Ulbrich K
Phase transition parameters of potential thermosensitive drug release systems based on polymers of N-alkylmethacrylamides.
Journal of biomaterials science. Polymer edition 1997;8(11):817-24.
1997: Rossmann P; Ríhová B; Strohalm J; Ulbrich K
Morphology of rat kidney and thymus after native and antibody-coupled cyclosporin A application (reduced toxicity of targeted drug).
Folia microbiologica 1997;42(3):277-87.
1996: Wolfert M A; Schacht E H; Toncheva V; Ulbrich K; Nazarova O; Seymour L W
Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers.
Human gene therapy 1996;7(17):2123-33.
1996: Pimm M V; Perkins A C; Strohalm J; Ulbrich K; Duncan R
Gamma scintigraphy of a 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate containing galactosamine following intravenous administration to nude mice bearing hepatic human colon carcinoma.
Journal of drug targeting 1996;3(5):385-90.
1996: Pimm M V; Perkins A C; Strohalm J; Ulbrich K; Duncan R
Gamma scintigraphy of the biodistribution of 123I-labelled N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in mice with transplanted melanoma and mammary carcinoma.
Journal of drug targeting 1996;3(5):375-83.
1995: Seymour L W; Miyamoto Y; Maeda H; Brereton M; Strohalm J; Ulbrich K; Duncan R
Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):766-70.
1995: Woerly S; Laroche G; Marchand R; Pato J; Subr V; Ulbrich K
Intracerebral implantation of hydrogel-coupled adhesion peptides: tissue reaction.
Journal of neural transplantation & plasticity 1995;5(4):245-55.
1994: Seymour L W; Ulbrich K; Steyger P S; Brereton M; Subr V; Strohalm J; Duncan R
Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma.
British journal of cancer 1994;70(4):636-41.
1994: Yen H R; Oscarsson S; Ulbrich K; Kopecek J
Adsorption and activation of zymogens at solid-liquid interfaces. I. Chymotrypsinogen on alkylamino modified silica derivatives.
Journal of biomedical materials research 1994;28(2):247-57.
1993: Woerly S; Maghami G; Duncan R; Subr V; Ulbrich K
Synthetic polymer derivatives as substrata for neuronal adhesion and growth.
Brain research bulletin 1993;30(3-4):423-32.
1993: O'Hare K B; Duncan R; Strohalm J; Ulbrich K; Kopeckova P
Polymeric drug-carriers containing doxorubicin and melanocyte-stimulating hormone: in vitro and in vivo evaluation against murine melanoma.
Journal of drug targeting 1993;1(3):217-29.
1993: Pimm M V; Perkins A C; Duncan R; Ulbrich K
Targeting of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate to the hepatocyte galactose-receptor in mice: visualisation and quantification by gamma scintigraphy as a basis for clinical targeting studies.
Journal of drug targeting 1993;1(2):125-31.
1991: Seymour L W; Ulbrich K; Wedge S R; Hume I C; Strohalm J; Duncan R
N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice.
British journal of cancer 1991;63(6):859-66.
1991: Yeung T K; Hopewell J W; Simmonds R H; Seymour L W; Duncan R; Bellini O; Grandi M; Spreafico F; Strohalm J; Ulbrich K
Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat.
Cancer chemotherapy and pharmacology 1991;29(2):105-11.
1991: Seymour L W; Flanagan P A; al-Shamkhani A; Subr V; Ulbrich K; Cassidy J; Duncan R
Synthetic polymers conjugated to monoclonal antibodies: vehicles for tumour-targeted drug delivery.
Selective cancer therapeutics 1991;7(2):59-73.
1990: Seymour L W; Ulbrich K; Strohalm J; Kopecek J; Duncan R
The pharmacokinetics of polymer-bound adriamycin.
Biochemical pharmacology 1990;39(6):1125-31.
1989: Rihova B; Bilej M; Vetvicka V; Ulbrich K; Strohalm J; Kopecek J; Duncan R
Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro.
Biomaterials 1989;10(5):335-42.
1984: Rihová B; Kopecek J; Ulbrich K; Pospisil M; Mancal P
Effect of the chemical structure of N-(2-hydroxypropyl)methacrylamide copolymers on their ability to induce antibody formation in inbred strains of mice.
Biomaterials 1984;5(3):143-8.
1983: Solovskij M V; Ulbrich K; Kopecek J
Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity.
Biomaterials 1983;4(1):44-8.
1983: Ríhová B; Ulbrich K; Kopecek J; Mancal P
Immunogenicity of N-(2-hydroxypropyl)-methacrylamide copolymers--potential hapten or drug carriers.
Folia microbiologica 1983;28(3):217-27.
1982: Ulbrich K; Strohalm J; Kopecek J
Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin.
Biomaterials 1982;3(3):150-4.
1980: Ulbrich K; Zacharieva E I; Obereigner B; Kopecek J
Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain.
Biomaterials 1980;1(4):199-204.

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