FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Axel Ullrich

Research Profile

Physiology

Phenomena

Phosphorylation

Chemicals & Drugs

Living Beings

Mouse
Rats

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

Co-author Network

Publications

TOP 3
Philip Vlaicu; Peter Widschwendter; Beyhan Ataseven; Wolfgang Eiermann; Bernhard Högel; Pjotr Knyazev; Thomas Mayr; Philipp Mertins; Axel Ullrich
Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator.
Han Kiat Ho; Z Horváth; György Kéri; G Németh; Y R Ng; E Pang; János Pató; I Szabadkai; Csaba Szántai-Kis; B Szokol; Axel Ullrich; L Zsákai; L Őrfî; F Baska; N Breza; Zoltán Greff; B T Chua
Developing FGFR4 inhibitors as potential anti-cancer agents via in silico design, supported by in vitro and cell-based testing.
Martin Bezler; Jan G Hengstler; Axel Ullrich
Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Axel Ullrich (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Philip Vlaicu; Peter Widschwendter; Beyhan Ataseven; Wolfgang Eiermann; Bernhard Högel; Pjotr Knyazev; Thomas Mayr; Philipp Mertins; Axel Ullrich
Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator.
BMC cancer 2013;13():197.
2013: Han Kiat Ho; Z Horváth; György Kéri; G Németh; Y R Ng; E Pang; János Pató; I Szabadkai; Csaba Szántai-Kis; B Szokol; Axel Ullrich; L Zsákai; L Őrfî; F Baska; N Breza; Zoltán Greff; B T Chua
Developing FGFR4 inhibitors as potential anti-cancer agents via in silico design, supported by in vitro and cell-based testing.
Current medicinal chemistry 2013;20(10):1203-17.
2012: Martin Bezler; Jan G Hengstler; Axel Ullrich
Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells.
Molecular oncology 2012;6(5):516-29.
2012: Claus Bender; Axel Ullrich
PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines.
International journal of cancer. Journal international du cancer 2012;131(2):E45-55.
2011: Majed S Alokail; Shaun B Sabico; Omar S Al-Attas; Nasser M Al-Daghri; Khalid M Alkharfy; Axel Ullrich
Visceral obesity and inflammation markers in relation to serum prostate volume biomarkers among apparently healthy men.
European journal of clinical investigation 2011;41(9):987-94.
2010: Boon Tin Chua; Shu Jing Lim; Su Chin Tham; Weijie Poh; Axel Ullrich
Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells.
Molecular oncology 2010;4(4):323-34.
2010: Markus Reschke; Ingvar Ferby; Ewa Stepniak; Nina Seitzer; David Horst; Erwin F Wagner; Axel Ullrich
Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2010;51(4):1383-90.
2010: A Roidl; P Foo; W Wong; C Mann; S Bechtold; Hans-Jürgen Berger; Sylvia Streit; Jens E Ruhe; Stefan Hart; Axel Ullrich; H K Ho
The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells.
Oncogene 2010;29(10):1543-52.
2010: Nina Seitzer; Thomas Mayr; Sylvia Streit; Axel Ullrich
A single nucleotide change in the mouse genome accelerates breast cancer progression.
Cancer research 2010;70(2):802-12.
2009: Arnaud Descot; Reinhard Hoffmann; Dmitry Shaposhnikov; Markus Reschke; Axel Ullrich; Guido Posern
Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction.
Molecular cell 2009;35(3):291-304.
2009: Andreas Roidl; Hans-Jürgen Berger; Sushil Kumar; Johannes Bange; Pjotr Knyazev; Axel Ullrich
Resistance to chemotherapy is associated with fibroblast growth factor receptor 4 up-regulation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(6):2058-66.
2009: Bhuminder Singh; Matthias Schneider; Pjotr Knyazev; Axel Ullrich
UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines.
International journal of cancer. Journal international du cancer 2009;124(3):531-9.
2009: Boon Tin Chua; David Gallego-Ortega; Ana Ramirez de Molina; Axel Ullrich; Juan Carlos Lacal; Julian Downward
Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.
Molecular cancer 2009;8():131.
2009: Han Kiat Ho; Sharon Pok; Sylvia Streit; Jens E Ruhe; Stefan Hart; Kah Suan Lim; Hooi Linn Loo; Myat Oo Aung; Seng Gee Lim; Axel Ullrich
Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention.
Journal of hepatology 2009;50(1):118-27.
2008: Philipp Mertins; H Christian Eberl; Jörg Renkawitz; Jesper V Olsen; Michel L Tremblay; Matthias Mann; Axel Ullrich; Henrik Daub
Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics.
Molecular & cellular proteomics : MCP 2008;7(9):1763-77.
2008: Markus Reschke; Daniela Mihic-Probst; Edward van der Horst; Pjotr Knyazev; Peter J Wild; Markus Hutterer; Stefanie Meyer; Reinhard Dummer; Holger Moch; Axel Ullrich
HER3 is a determinant for poor prognosis in melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(16):5188-97.
2008: Nikolas Hendrik Stoecklein; Stefan B Hosch; Martin Bezler; Franziska Stern; Claudia H Hartmann; Christian Vay; Annika Siegmund; Peter Scheunemann; Paulus Schurr; Wolfram T Knoefel; Pablo E Verde; Uta Reichelt; Andreas Erbersdobler; Roger Grau; Axel Ullrich; Jakob R Izbicki; Christoph A Klein
Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.
Cancer cell 2008;13(5):441-53.
2008: Yi-Xiang Zhang; Pjotr Knyazev; Yuri V Cheburkin; Kirti Sharma; Yuri P Knyazev; László Őrfi; István Szabadkai; Henrik Daub; György Kéri; Axel Ullrich
AXL is a potential target for therapeutic intervention in breast cancer progression.
Cancer research 2008;68(6):1905-15.
2008: Markus Hutterer; Pjotr Knyazev; Ariane Abate; Markus Reschke; Hans Maier; Nadia Stefanova; Tatjana Knyazeva; Verena Barbieri; Markus Reindl; Armin Muigg; Herwig Kostron; Günther Stockhammer; Axel Ullrich
Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):130-8.
2007: Jens E Ruhe; Sylvia Streit; Stefan Hart; Chee-Hong Wong; Katja Specht; Pjotr Knyazev; Tatjana Knyazeva; Liang Seah Tay; Hooi Linn Loo; Priscilla Foo; Winnie Wong; Sharon Pok; Shu Jing Lim; Huimin Ong; Ming Luo; Han Kiat Ho; Kaitian Peng; Tze Chuen Lee; Martin Bezler; Christian Mann; Silvia Gaertner; Heinz Hoefler; Stefano Iacobelli; Stephan Peter; Alice Tay; Sydney Brenner; Byrappa Venkatesh; Axel Ullrich
Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines.
Cancer research 2007;67(23):11368-76.
2007: Attila Steták; Réka Veress; Judit Ovádi; Péter Csermely; György Kéri; Axel Ullrich
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.
Cancer research 2007;67(4):1602-8.
2006: Indranil Bhattacharya; Axel Ullrich
Endothelin-1 inhibits adipogenesis: role of phosphorylation of Akt and ERK1/2.
FEBS letters 2006;580(24):5765-71.
2006: Sylvia Streit; Jens E Ruhe; Pjotr Knyazev; Tatjana Knyazeva; Stefano Iacobelli; Stephan Peter; Heinz Hoefler; Axel Ullrich
PTP-PEST phosphatase variations in human cancer.
Cancer genetics and cytogenetics 2006;170(1):48-53.
2006: Berno Tanner; Dirk Hasenclever; Katja Stern; Wiebke Schormann; Martin Bezler; Matthias Hermes; Marc Brulport; Alexander Bauer; Ilka B Schiffer; Susanne Gebhard; Markus Schmidt; Eric Steiner; Jalid Sehouli; Jeanett Edelmann; Jürgen Läuter; Rüdiger Lessig; Krishnamurthi Kannan; Axel Ullrich; Jan G Hengstler
ErbB-3 predicts survival in ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(26):4317-23.
2006: Jens E Ruhe; Sylvia Streit; Stefan Hart; Axel Ullrich
EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing.
Cellular signalling 2006;18(9):1515-27.
2006: Christoph Thussbas; Jörg Nahrig; Sylvia Streit; Johannes Bange; Monika Kriner; Ronald Kates; Kurt Ulm; Marion Kiechle; Heinz Hoefler; Axel Ullrich; Nadia Harbeck
FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(23):3747-55.
2006: Sylvia Streit; D S Mestel; M Schmidt; Axel Ullrich; Carola Berking
FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients.
British journal of cancer 2006;94(12):1879-86.
2006: Christiane Regina Stadler; Pjotr Knyazev; Johannes Bange; Axel Ullrich
FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression.
Cellular signalling 2006;18(6):783-94.
2006: Ingvar Ferby; Markus Reschke; Oliver Kudlacek; Pjotr Knyazev; Guido Pantè; Kerstin Amann; Wolfgang Sommergruber; Norbert Kraut; Axel Ullrich; Reinhard Fässler; Rüdiger Klein
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation.
Nature medicine 2006;12(5):568-73.
2006: Lars Anders; Philipp Mertins; Sven Lammich; Marta Murgia; Dieter Hartmann; Paul Saftig; Christian Haass; Axel Ullrich
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.
Molecular and cellular biology 2006;26(10):3917-34.
2006: Peter Vajkoczy; Pjotr Knyazev; Andrea Kunkel; Hans-Holger Capelle; Sandra Behrndt; Hendrik von Tengg-Kobligk; Fabian Kiessling; Uta Eichelsbacher; Marco Essig; Tracy-Ann Read; Ralf Erber; Axel Ullrich
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5799-804.
2006: Ralf Erber; Uta Eichelsbacher; Violetta Powajbo; Tobias Korn; Valentin Djonov; Jihong Lin; Hans-Peter Hammes; Rainer Grobholz; Axel Ullrich; Peter Vajkoczy
EphB4 controls blood vascular morphogenesis during postnatal angiogenesis.
The EMBO journal 2006;25(3):628-41.
2006: Takako Sasaki; Pjotr Knyazev; Naomi J Clout; Yuri Cheburkin; Walter Göhring; Axel Ullrich; Rupert Timpl; Erhard Hohenester
Structural basis for Gas6-Axl signalling.
The EMBO journal 2006;25(1):80-7.
2006: Csaba Szántai-Kis; István Kövesdi; Dániel Eros; Péter Bánhegyi; Axel Ullrich; György Kéri; László Õrfi
Prediction oriented QSAR modelling of EGFR inhibition.
Current medicinal chemistry 2006;13(3):277-87.
2005: Reimar Abraham; Juliane Schäfer; Mike Rothe; Johannes Bange; Pjotr Knyazev; Axel Ullrich
Identification of MMP-15 as an anti-apoptotic factor in cancer cells.
The Journal of biological chemistry 2005;280(40):34123-32.
2005: György Kéri; Zsolt Székelyhidi; Péter Bánhegyi; Zoltán Varga; Bálint Hegymegi-Barakonyi; Csaba Szántai-Kis; Doris Hafenbradl; Bert Klebl; Gerhard Muller; Axel Ullrich; Dániel Erös; Zoltán Horváth; Zoltán Greff; Jenö Marosfalvi; János Pató; István Szabadkai; Ildikó Szilágyi; Zsolt Szegedi; István Varga; Frigyes Wáczek; László Õrfi
Drug discovery in the kinase inhibitory field using the Nested Chemical Library technology.
Assay and drug development technologies 2005;3(5):543-51.
2005: Stefan Hart; Oliver M Fischer; Norbert Prenzel; Esther Zwick-Wallasch; Matthias Schneider; Lothar Hennighausen; Axel Ullrich
GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.
Biological chemistry 2005;386(9):845-55.
2005: Klaus Godl; Oliver J Gruss; Jan Eickhoff; Josef Wissing; Stephanie Blencke; Martina Weber; Heidrun Degen; Dirk Brehmer; László Õrfi; Zoltán Horváth; György Kéri; Stefan Müller; Matt Cotten; Axel Ullrich; Henrik Daub
Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling.
Cancer research 2005;65(15):6919-26.
2005: Edward van der Horst; Marta Murgia; Martin Treder; Axel Ullrich
Anti-HER-3 MAbs inhibit HER-3-mediated signaling in breast cancer cell lines resistant to anti-HER-2 antibodies.
International journal of cancer. Journal international du cancer 2005;115(4):519-27.
2005: Ingemarie R Berger; Marcus Buschbeck; Johannes Bange; Axel Ullrich
Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2.
Cancer genetics and cytogenetics 2005;159(2):155-9.
2005: Margit Fuchs; Christine Hermannstädter; Katja Specht; Pjotr Knyazev; Axel Ullrich; Erika Rosivatz; Raymonde Busch; Peter Hutzler; Heinz Höfler; Birgit Luber
Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3.
Journal of cellular physiology 2005;202(3):805-13.
2005: Edward van der Horst; Igor Weber; Axel Ullrich
Tyrosine phosphorylation of PYK2 mediates heregulin-induced glioma invasion: novel heregulin/HER3-stimulated signaling pathway in glioma.
International journal of cancer. Journal international du cancer 2005;113(5):689-98.
2005: Mohammad Reza Farhadi; Hans-Holger Capelle; Ralf Erber; Axel Ullrich; Peter Vajkoczy
Combined inhibition of vascular endothelial growth factor and platelet-derived growth factor signaling: effects on the angiogenesis, microcirculation, and growth of orthotopic malignant gliomas.
Journal of neurosurgery 2005;102(2):363-70.
2005: Marcus Buschbeck; Axel Ullrich
The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling.
The Journal of biological chemistry 2005;280(4):2659-67.
2005: Marcus Buschbeck; Sebastian Walter Hofbauer; Luciano Di Croce; Gyorgy Keri; Axel Ullrich
Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival.
EMBO reports 2005;6(1):63-9.
2004: Edward van der Horst; Joerg H Leupold; Rainer Schubbert; Axel Ullrich; Heike Allgayer
TaqMan-based quantification of invasive cells in the chick embryo metastasis assay.
BioTechniques 2004;37(6):940-2, 944, 946.
2004: Henrik Daub; Katja Specht; Axel Ullrich
Strategies to overcome resistance to targeted protein kinase inhibitors.
Nature reviews. Drug discovery 2004;3(12):1001-10.
2004: Beatrix Schäfer; Beatrice Marg; Andreas Gschwind; Axel Ullrich
Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival.
The Journal of biological chemistry 2004;279(46):47929-38.
2004: Anja Ruschel; Axel Ullrich
Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells.
Cellular signalling 2004;16(11):1249-61.
2004: Sylvia Streit; Johannes Bange; Alexander Fichtner; Stephan Ihrler; Wolfgang J Issing; Axel Ullrich
Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2004;111(2):213-7.
2004: Oliver M Fischer; Silvia Giordano; paolo comoglio; Axel Ullrich
Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells.
The Journal of biological chemistry 2004;279(28):28970-8.
2004: Oliver M Fischer; Stefan Hart; Andreas Gschwind; Norbert Prenzel; Axel Ullrich
Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor.
Molecular and cellular biology 2004;24(12):5172-83.
2004: Stephanie Blencke; Birgit Zech; Ola Engkvist; Zoltán Greff; László Õrfi; Zoltán Horváth; György Kéri; Axel Ullrich; Henrik Daub
Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors.
Chemistry & biology 2004;11(5):691-701.
2004: Andreas Gschwind; Oliver M Fischer; Axel Ullrich
The discovery of receptor tyrosine kinases: targets for cancer therapy.
Nature reviews. Cancer 2004;4(5):361-70.
2004: Miriam Gensler; Marcus Buschbeck; Axel Ullrich
Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.
The Journal of biological chemistry 2004;279(13):12110-6.
2004: Stefan Hart; Oliver M Fischer; Axel Ullrich
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
Cancer research 2004;64(6):1943-50.
2004: Anil Koul; Thomas Herget; Bert Klebl; Axel Ullrich
Interplay between mycobacteria and host signalling pathways.
Nature reviews. Microbiology 2004;2(3):189-202.
2004: Ralf Erber; Andreas Thurnher; Alice D Katsen; Gesine Groth; Heinz Kerger; Hans-Peter Hammes; Michael D Menger; Axel Ullrich; Peter Vajkoczy
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):338-40.
2004: Beatrix Schäfer; Andreas Gschwind; Axel Ullrich
Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion.
Oncogene 2004;23(4):991-9.
2004: Rafael Pulido; Angel Zúñiga; Axel Ullrich
Detection of ERK1/2 activities using affinity reagents.
Methods in molecular biology (Clifton, N.J.) 2004;250():49-60.
2003: Oliver M Fischer; Stefan Hart; Andreas Gschwind; Axel Ullrich
EGFR signal transactivation in cancer cells.
Biochemical Society transactions 2003;31(Pt 6):1203-8.
2003: Yingjie Wu; Zhengjun Chen; Axel Ullrich
EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.
Biological chemistry 2003;384(8):1215-26.
2003: Oliver M Fischer; Sylvia Streit; Stefan Hart; Axel Ullrich
Beyond Herceptin and Gleevec.
Current opinion in chemical biology 2003;7(4):490-5.
2003: Andreas Gschwind; Stefan Hart; Oliver M Fischer; Axel Ullrich
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.
The EMBO journal 2003;22(10):2411-21.
2003: Stephanie Blencke; Axel Ullrich; Henrik Daub
Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors.
The Journal of biological chemistry 2003;278(17):15435-40.
2002: Takako Sasaki; Pjotr Knyazev; Yuri Cheburkin; Walter Göhring; Dominic Tisi; Axel Ullrich; Rupert Timpl; Erhard Hohenester
Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains.
The Journal of biological chemistry 2002;277(46):44164-70.
2002: Andreas Gschwind; Norbert Prenzel; Axel Ullrich
Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.
Cancer research 2002;62(21):6329-36.
2002: Marcus Buschbeck; Jan Eickhoff; Marc N Sommer; Axel Ullrich
Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway.
The Journal of biological chemistry 2002;277(33):29503-9.
2002: Henrik Daub; Stephanie Blencke; Peter Habenberger; Alexander Kurtenbach; Julia Dennenmoser; Josef Wissing; Axel Ullrich; Matt Cotten
Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.
Journal of virology 2002;76(16):8124-37.
2002: C Wallasch; J E Crabtree; Dorian Bevec; P A Robinson; H Wagner; Axel Ullrich
Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF.
Biochemical and biophysical research communications 2002;295(3):695-701.
2002: Antonio Marchetti; Nicola Tinari; Fiamma Buttitta; Antonio Chella; Carlo Alberto Angeletti; Rocco Sacco; Felice Mucilli; Axel Ullrich; Stefano Iacobelli
Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients.
Cancer research 2002;62(9):2535-9.
2002: Laura K Shawver; Dennis J Slamon; Axel Ullrich
Smart drugs: tyrosine kinase inhibitors in cancer therapy.
Cancer cell 2002;1(2):117-23.
2002: Johannes Bange; Dieter Prechtl; Yuri Cheburkin; Katja Specht; Nadia Harbeck; Manfred Schmitt; Tatjana Knyazeva; Susanne Müller; Silvia Gärtner; Irmi Sures; Hongyang Wang; Evgeny Imyanitov; Hans-Ulrich Häring; Pjotr Knayzev; Stefano Iacobelli; Heinz Höfler; Axel Ullrich
Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.
Cancer research 2002;62(3):840-7.
2002: Volker Strack; Jan Krützfeldt; Monika Kellerer; Axel Ullrich; Reiner Lammers; Hans-Ulrich Häring
The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.
Biochemistry 2002;41(2):603-8.
2002: Axel Ullrich
Molecular targets in cancer therapy and their impact on cancer management.
Oncology 2002;63 Suppl 1():1-5.
2002: Esther Zwick; Johannes Bange; Axel Ullrich
Receptor tyrosine kinases as targets for anticancer drugs.
Trends in molecular medicine 2002;8(1):17-23.
2001: PO Hackel; M Gishizky; Axel Ullrich
Mig-6 is a negative regulator of the epidermal growth factor receptor signal.
Biological chemistry 2001;382(12):1649-62.
2001: Attila Steták; Péter Csermely; Axel Ullrich; György Kéri
Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.
Biochemical and biophysical research communications 2001;288(3):564-72.
2001: Anita M Hennige; Reiner Lammers; Wolfgang Höppner; Dorit Arlt; Volker Strack; Reinhard Teichmann; Fausto Machicao; Axel Ullrich; Hans-Ulrich Häring; Monika Kellerer
Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1.
Endocrinology 2001;142(10):4441-7.
2001: Monika Kellerer; Reiner Lammers; Andreas Fritsche; Volker Strack; Fausto Machicao; P Borboni; Axel Ullrich; Hans-Ulrich Häring
Insulin inhibits leptin receptor signalling in HEK293 cells at the level of janus kinase-2: a potential mechanism for hyperinsulinaemia-associated leptin resistance.
Diabetologia 2001;44(9):1125-32.
2001: Esther Zwick; Johannes Bange; Axel Ullrich
Receptor tyrosine kinase signalling as a target for cancer intervention strategies.
Endocrine-related cancer 2001;8(3):161-73.
2001: Attila Steták; A Lankenau; Tibor Vantus; Péter Csermely; Axel Ullrich; György Kéri
The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCdelta and c-Src.
Biochemical and biophysical research communications 2001;285(2):483-8.
2001: Johannes Bange; Esther Zwick; Axel Ullrich
Molecular targets for breast cancer therapy and prevention.
Nature medicine 2001;7(5):548-52.
2001: Andreas Gschwind; Esther Zwick; Norbert Prenzel; M Leserer; Axel Ullrich
Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission.
Oncogene 2001;20(13):1594-600.
2001: Norbert Prenzel; Oliver M Fischer; Sylvia Streit; Stefan Hart; Axel Ullrich
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.
Endocrine-related cancer 2001;8(1):11-31.
2001: J Schultz; T Jones; P Bork; Denise Sheer; Stephanie Blencke; S Steyrer; U Wellbrock; Dorian Bevec; Axel Ullrich; C Wallasch
Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35 [correction of 4q35].
Genomics 2001;71(3):368-70.
2001: A Horvat; Franz-Werner Schwaiger; Gerhard Hager; F Brocker; Robert Streif; Pjotr Knyazev; Axel Ullrich; Georg W Kreutzberg
A novel role for protein tyrosine phosphatase shp1 in controlling glial activation in the normal and injured nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(3):865-74.
2000: Anil Koul; A Choidas; M Treder; Akhilesh K Tyagi; Karl Drlica; Yogendra Singh; Axel Ullrich
Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis.
Journal of bacteriology 2000;182(19):5425-32.
2000: A Douglas Laird; Peter Vajkoczy; Laura K Shawver; Andreas Thurnher; Congxin Liang; M Mohammadi; J Schlessinger; Axel Ullrich; Stevan Hubbard; Robert Blake; TA Fong; LM Strawn; Li Sun; Cho Tang; R Hawtin; F Tang; Narmada Shenoy; KP Hirth; Gerald McMahon
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
Cancer research 2000;60(15):4152-60.
2000: Peter Vajkoczy; Michael D Menger; R Goldbrunner; S Ge; TA Fong; B Vollmar; L Schilling; Axel Ullrich; KP Hirth; Jörg C Tonn; P Schmiedek; Sandra Rempel
Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC.
International journal of cancer. Journal international du cancer 2000;87(2):261-8.
2000: B Bossenmaier; Volker Strack; B Stoyanov; Jan Krützfeldt; A Beck; R Lehmann; Monika Kellerer; H Klein; Axel Ullrich; Reiner Lammers; Hans-Ulrich Häring
Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.
Diabetes 2000;49(6):889-95.
2000: M Leserer; Andreas Gschwind; Axel Ullrich
Epidermal growth factor receptor signal transactivation.
IUBMB life 2000;49(5):405-9.
2000: Reiner Lammers; M M Lerch; Axel Ullrich
The carboxyl-terminal tyrosine residue of protein-tyrosine phosphatase alpha mediates association with focal adhesion plaques.
The Journal of biological chemistry 2000;275(5):3391-6.
2000: Esther Zwick; C Wallasch; Axel Ullrich
HER2/neu: a target for breast cancer therapy.
Breast disease 2000;11():7-18.
2000: Norbert Prenzel; Esther Zwick; M Leserer; Axel Ullrich
Tyrosine kinase signalling in breast cancer. Epidermal growth factor receptor: convergence point for signal integration and diversification.
Breast cancer research : BCR 2000;2(3):184-90.
2000: Peter Vajkoczy; Axel Ullrich; Michael D Menger
Intravital fluorescence videomicroscopy to study tumor angiogenesis and microcirculation.
Neoplasia (New York, N.Y.) 2000;2(1-2):53-61.
2000: Peter Vajkoczy; Andreas Thurnher; KP Hirth; L Schilling; P Schmiedek; Axel Ullrich; Michael D Menger
Measuring VEGF-Flk-1 activity and consequences of VEGF-Flk-1 targeting in vivo using intravital microscopy: clinical applications.
The oncologist 2000;5 Suppl 1():16-9.
1999: Norbert Prenzel; Esther Zwick; Henrik Daub; M Leserer; R Abraham; C Wallasch; Axel Ullrich
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF.
Nature 1999;402(6764):884-8.
1999: Cornelia Dorner; Axel Ullrich; Hans-Ulrich Häring; Reiner Lammers
The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family.
The Journal of biological chemistry 1999;274(47):33654-60.
1999: C P Bagowski; M Stein-Gerlach; A Choidas; Axel Ullrich
Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor.
The EMBO journal 1999;18(20):5567-76.
1999: Esther Zwick; PO Hackel; Norbert Prenzel; Axel Ullrich
The EGF receptor as central transducer of heterologous signalling systems.
Trends in pharmacological sciences 1999;20(10):408-12.
1999: Esther Zwick; C Wallasch; Henrik Daub; Axel Ullrich
Distinct calcium-dependent pathways of epidermal growth factor receptor transactivation and PYK2 tyrosine phosphorylation in PC12 cells.
The Journal of biological chemistry 1999;274(30):20989-96.
1999: Cord Brakebusch; Irmi Sures; Bahija Jallal; K Mossie; O Fusco; Stefano Iacobelli; Axel Ullrich
Isolation and functional characterization of the human 90K promoter.
Genomics 1999;57(2):268-78.
1999: T Müller; A Choidas; E Reichmann; Axel Ullrich
Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration.
The Journal of biological chemistry 1999;274(15):10173-83.
1999: Peter Vajkoczy; Michael D Menger; B Vollmar; L Schilling; P Schmiedek; KP Hirth; Axel Ullrich; TA Fong
Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy.
Neoplasia (New York, N.Y.) 1999;1(1):31-41.
1999: PO Hackel; Esther Zwick; Norbert Prenzel; Axel Ullrich
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
Current opinion in cell biology 1999;11(2):184-9.
1999: TA Fong; Laura K Shawver; Li Sun; Cho Tang; H App; T J Powell; Y H Kim; Randall E Schreck; Xueyan Wang; W Risau; Axel Ullrich; KP Hirth; Gerald McMahon
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.
Cancer research 1999;59(1):99-106.
1998: Oliver Nayler; F Schnorrer; Stefan Stamm; Axel Ullrich
The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation.
The Journal of biological chemistry 1998;273(51):34341-8.
1998: Rafael Pulido; Angel Zúñiga; Axel Ullrich
PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.
The EMBO journal 1998;17(24):7337-50.
1998: A Choidas; A Jungbluth; A Sechi; J Murphy; Axel Ullrich; Gerard Marriott
The suitability and application of a GFP-actin fusion protein for long-term imaging of the organization and dynamics of the cytoskeleton in mammalian cells.
European journal of cell biology 1998;77(2):81-90.
1998: Cornelia Dorner; T Ciossek; S Müller; P H Møller; Axel Ullrich; Reiner Lammers
Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum.
The Journal of biological chemistry 1998;273(32):20267-75.
1998: Oliver Nayler; W Strätling; Jean-Pierre Bourquin; Igor Stagljar; L Lindemann; H Jasper; AM Hartmann; Frank Fackelmayer; Axel Ullrich; Stefan Stamm
SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements.
Nucleic acids research 1998;26(15):3542-9.
1998: A Herrlich; Henrik Daub; Axel Knebel; Peter Herrlich; Axel Ullrich; Günter Schultz; Thomas Gudermann
Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8985-90.
1998: Monika Kellerer; Joanne Mushack; E Seffer; Mischak Harald; Axel Ullrich; Hans-Ulrich Häring
Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).
Diabetologia 1998;41(7):833-8.
1998: M Stein-Gerlach; C Wallasch; Axel Ullrich
SHP-2, SH2-containing protein tyrosine phosphatase-2.
The international journal of biochemistry & cell biology 1998;30(5):559-66.
1998: Y Kubota; T Angelotti; G Niederfellner; Ronald Herbst; Axel Ullrich
Activation of phosphatidylinositol 3-kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(3):247-56.
1998: O Fusco; Patrizia Querzoli; Italo Nenci; Clara Natoli; C Brakebush; Axel Ullrich; Stefano Iacobelli
90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells.
International journal of cancer. Journal international du cancer 1998;79(1):23-6.
1998: Reiner Lammers; Niels Peter H Møller; Axel Ullrich
Mutant forms of the protein tyrosine phosphatase alpha show differential activities towards intracellular substrates.
Biochemical and biophysical research communications 1998;242(1):32-8.
1998: M Fuchs; H Wang; T Ciossek; Z Chen; Axel Ullrich
Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development.
Mechanisms of development 1998;70(1-2):91-109.
1997: Henrik Daub; C Wallasch; A Lankenau; A Herrlich; Axel Ullrich
Signal characteristics of G protein-transactivated EGF receptor.
The EMBO journal 1997;16(23):7032-44.
1997: F U Weiss; C Wallasch; M Campiglio; Wolfgang J Issing; Axel Ullrich
Distinct characteristics of heregulin signals mediated by HER3 or HER4.
Journal of cellular physiology 1997;173(2):187-95.
1997: Esther Zwick; Henrik Daub; N Aoki; Y Yamaguchi-Aoki; Inge Tinhofer; Karl Maly; Axel Ullrich
Critical role of calcium- dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling.
The Journal of biological chemistry 1997;272(40):24767-70.
1997: Oliver Nayler; Stefan Stamm; Axel Ullrich
Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.
The Biochemical journal 1997;326 ( Pt 3)():693-700.
1997: B Aicher; M M Lerch; T Müller; J Schilling; Axel Ullrich
Cellular redistribution of protein tyrosine phosphatases LAR and PTPsigma by inducible proteolytic processing.
The Journal of cell biology 1997;138(3):681-96.
1997: Laura K Shawver; D P Schwartz; E Mann; Hui Chen; J Tsai; L Chu; L Taylorson; M Longhi; S Meredith; L Germain; J S Jacobs; Cho Tang; Axel Ullrich; Michael Berens; Evan M Hersh; Gerald McMahon; KP Hirth; T J Powell
Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(7):1167-77.
1997: B Bossenmaier; L Mosthaf; H Mischak; Axel Ullrich; Hans-Ulrich Häring
Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor.
Diabetologia 1997;40(7):863-6.
1997: J Braunger; L Schleithoff; A S Schulz; H Kessler; R Lammers; Axel Ullrich; Claus R Bartram; Johannes W G Janssen
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
Oncogene 1997;14(22):2619-31.
1997: Bahija Jallal; K Mossie; G Vasiloudis; P Knyazev; J Zachwieja; Felix Clairvoyant; J Schilling; Axel Ullrich
The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase.
The Journal of biological chemistry 1997;272(18):12158-63.
1997: A Kharitonenkov; Z Chen; Irmi Sures; H Wang; J Schilling; Axel Ullrich
A family of proteins that inhibit signalling through tyrosine kinase receptors.
Nature 1997;386(6621):181-6.
1997: Reiner Lammers; N P Møłler; Axel Ullrich
The transmembrane protein tyrosine phosphatase alpha dephosphorylates the insulin receptor in intact cells.
FEBS letters 1997;404(1):37-40.
1997: T Tenev; H Keilhack; S Tomic; B Stoyanov; M Stein-Gerlach; Reiner Lammers; A V Krivtsov; Axel Ullrich; Frank-D Böhmer
Both SH2 domains are involved in interaction of SHP-1 with the epidermal growth factor receptor but cannot confer receptor-directed activity to SHP-1/SHP-2 chimera.
The Journal of biological chemistry 1997;272(9):5966-73.
1997: Cord Brakebusch; Bahija Jallal; O Fusco; Stefano Iacobelli; Axel Ullrich
Expression of the 90K immunostimulator gene is controlled by a promoter with unique features.
The Journal of biological chemistry 1997;272(6):3674-82.
1997: F U Weiss; Henrik Daub; Axel Ullrich
Novel mechanisms of RTK signal generation.
Current opinion in genetics & development 1997;7(1):80-6.
1997: T Ciossek; Axel Ullrich
Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1.
Oncogene 1997;14(1):35-43.