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Philippe Bouillet

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Jeffrey B Kerr; Seng Liew; Ewa M Michalak; Alea Mills; Clare L Scott; Philippe Bouillet; Michele Cook; Jock K Findlay; Karla J Hutt; Cassandra J Vandenberg; Andreas Strasser
DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.
Daniel H D Gray; Marco J Herold; Fiona Kupresanin; Lorraine A O'Reilly; Stuart P Berzins; Philippe Bouillet; Andreas Strasser
The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.
Delphine Mérino; Andreas Strasser; Philippe Bouillet
Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.

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2012: Jeffrey B Kerr; Seng Liew; Ewa M Michalak; Alea Mills; Clare L Scott; Philippe Bouillet; Michele Cook; Jock K Findlay; Karla J Hutt; Cassandra J Vandenberg; Andreas Strasser
DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.
Molecular cell 2012;48(3):343-52.
2012: Daniel H D Gray; Marco J Herold; Fiona Kupresanin; Lorraine A O'Reilly; Stuart P Berzins; Philippe Bouillet; Andreas Strasser
The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.
Immunity 2012;37(3):451-62.
2012: Delphine Mérino; Andreas Strasser; Philippe Bouillet
Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.
Oncogene 2012;31(28):3392-6.
2012: Delphine Mérino; Belinda Phipson; Mikara Robati; Andrew W Roberts; Cassandra J Vandenberg; Chihunt Wong; Peng Yue; Daniel J Anderson; Lisa D Belmont; Kirsteen J Campbell; Suzanne Cory; W Douglas Fairlie; Stefan P Glaser; David C S Huang; Seong L Khaw; Erinna Lee; Mary J C Ludlam; Philippe Bouillet
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Blood 2012;119(24):5807-16.
2012: F Ke; J B Kerr; L A O'Reilly; Andreas Strasser; L Tai; A Voss; Philippe Bouillet; N Echeverry; T Kaufmann
BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.
Cell death and differentiation 2012;19(6):915-25.
2012: C Clybouw; R J Davis; A Hübner; F Masson; D Merino; T Nebl; L O'Reilly; Mikara Robati; Andreas Strasser; Philippe Bouillet
Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.
Cell death and differentiation 2012;19(6):1060-8.
2012: Stefan P Glaser; Marco J Herold; David J Izon; Erinna Lee; Scott W Lowe; Amy R Rappaport; Lorraine Robb; Warren S Alexander; Philippe Bouillet; W Douglas Fairlie; Evelyn Trounson; Andrew Wei; Johannes Zuber; Andreas Strasser
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia.
Genes & development 2012;26(2):120-5.
2012: M Giam; Justine D Mintern; T Okamoto; Andreas Strasser; Philippe Bouillet
Bcl-2 family member Bcl-G is not a proapoptotic protein.
Cell death & disease 2012;3():e404.
2011: Yifan Zhan; Yuxia Zhang; Lorraine O'Reilly; Andreas Strasser; Ian P Wicks; Philippe Bouillet; Emma M Carrington; Daniel Gray; Hyun-Ja Ko; Andrew M Lew
Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1566-77.
2011: Ben A Croker; Grant Dewson; Yifang Hu; Kurt Lackovic; Donald Metcalf; Cameron Nowell; Joanne A O'Donnell; Lorraine A O'Reilly; Philippe Bouillet; Kirsteen J Campbell; Louise H Cengia; Suzanne Cory; Kelly L Rogers; Gordon K Smyth; Andreas Strasser; Michael White; Jian-Guo Zhang; Andrew W Roberts
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13135-40.
2011: Edwina Naik; Lorraine A O'Reilly; Jerry M Adams; Marie-Liesse Asselin-Labat; Philippe Bouillet; Michele Cook; Leigh Coultas; Ann Lin; Delphine Merino; Andreas Strasser
Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells.
The Journal of experimental medicine 2011;208(7):1351-8.
2010: Ingela Vikstrom; Sebastian Carotta; Katja Lüthje; Victor Peperzak; Philipp J Jost; Stefan Glaser; Meinrad Busslinger; Philippe Bouillet; Andreas Strasser; Stephen L Nutt; David M Tarlinton
Mcl-1 is essential for germinal center formation and B cell memory.
Science (New York, N.Y.) 2010;330(6007):1095-9.
2010: Karen A Fortner; Philippe Bouillet; Andreas Strasser; Ralph C Budd
Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation.
European journal of immunology 2010;40(11):3043-53.
2010: Kirsteen J Campbell; Mary L Bath; Marian L Turner; Cassandra J Vandenberg; Philippe Bouillet; Donald Metcalf; Clare L Scott; Suzanne Cory
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.
Blood 2010;116(17):3197-207.
2010: P N Kelly; M J White; M W Goschnick; K A Fairfax; David M Tarlinton; S A Kinkel; Philippe Bouillet; J M Adams; B T Kile; Andreas Strasser
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development.
Cell death and differentiation 2010;17(10):1655-64.
2009: Lorraine A O' Reilly; Lin Tai; Lily Lee; Elizabeth A Kruse; Stephanie Grabow; W Douglas Fairlie; Nicole M Haynes; David M Tarlinton; Jian-Guo Zhang; Gabrielle T Belz; Mark J Smyth; Philippe Bouillet; Lorraine Robb; Andreas Strasser
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.
Nature 2009;461(7264):659-63.
2009: Philipp J Jost; Stephanie Grabow; Daniel Gray; Mark D McKenzie; Ueli Nachbur; David C S Huang; Philippe Bouillet; Helen E Thomas; Christoph Borner; John Silke; Andreas Strasser; Thomas Kaufmann
XIAP discriminates between type I and type II FAS-induced apoptosis.
Nature 2009;460(7258):1035-9.
2009: Delphine Mérino; Maybelline Giam; Peter D Hughes; Owen M Siggs; Klaus Heger; Lorraine A O'Reilly; Jerry M Adams; Andreas Strasser; Erinna Lee; W Douglas Fairlie; Philippe Bouillet
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins.
The Journal of cell biology 2009;186(3):355-62.
2009: Philippe Bouillet; Lorraine A O'Reilly
CD95, BIM and T cell homeostasis.
Nature reviews. Immunology 2009;9(7):514-9.
2009: Thomas Kaufmann; Philipp J Jost; Marc Pellegrini; Hamsa Puthalakath; Raffi Gugasyan; Steve Gerondakis; Erika Cretney; Mark J Smyth; John Silke; Razq Hakem; Philippe Bouillet; Tak W Mak; Xiaodong Huang; Andreas Strasser
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Immunity 2009;30(1):56-66.
2008: M Giam; David C S Huang; Philippe Bouillet
BH3-only proteins and their roles in programmed cell death.
Oncogene 2008;27 Suppl 1():S128-36.
2008: Peter D Hughes; Gabrielle Belz; Karen A Fortner; Ralph C Budd; Andreas Strasser; Philippe Bouillet
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity.
Immunity 2008;28(2):197-205.
2008: Erinna Lee; Peter Czabotar; Mark F Van Delft; Ewa M Michalak; Michelle J Boyle; Simon N Willis; Hamsa Puthalakath; Philippe Bouillet; Peter M Colman; David C S Huang; W Douglas Fairlie
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
The Journal of cell biology 2008;180(2):341-55.
2008: Andreas Strasser; Hamsa Puthalakath; Lorraine A O'Reilly; Philippe Bouillet
What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain.
Immunology and cell biology 2008;86(1):57-66.
2007: Silke F Fischer; Philippe Bouillet; Kristy O'Donnell; Amanda Light; David M Tarlinton; Andreas Strasser
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells.
Blood 2007;110(12):3978-84.
2007: Hamsa Puthalakath; Lorraine A O'Reilly; Priscilla Gunn; Lily Lee; Priscilla N Kelly; Nicholas D Huntington; Peter D Hughes; Ewa M Michalak; Jennifer L McKimm-Breschkin; Noburo Motoyama; Tomomi Gotoh; Shizuo Akira; Philippe Bouillet; Andreas Strasser
ER stress triggers apoptosis by activating BH3-only protein Bim.
Cell 2007;129(7):1337-49.
2007: Leigh Coultas; Susanna Terzano; Tim Thomas; Anne Voss; Kate Reid; Edouard G Stanley; Clare L Scott; Philippe Bouillet; Perry Bartlett; Jonathan Ham; Jerry M Adams; Andreas Strasser
Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.
Journal of cell science 2007;120(Pt 12):2044-52.
2007: Simon N Willis; Jamie I Fletcher; Thomas Kaufmann; Mark F Van Delft; Lin Chen; Peter Czabotar; Helen Ierino; Erinna Lee; W Douglas Fairlie; Philippe Bouillet; Andreas Strasser; Ruth M Kluck; Jerry M Adams; David C S Huang
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
Science (New York, N.Y.) 2007;315(5813):856-9.
2006: Junya Kuroda; Hamsa Puthalakath; Mark Cragg; Priscilla N Kelly; Philippe Bouillet; David C S Huang; Shinya Kimura; Oliver G Ottmann; Brian J Druker; Andreas Villunger; Andrew W Roberts; Andreas Strasser
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14907-12.
2006: P Hughes; Mikara Robati; W Lu; J Zhou; Andreas Strasser; Philippe Bouillet
Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.
Cell death and differentiation 2006;13(7):1123-7.
2006: Peter Hughes; Philippe Bouillet; Andreas Strasser
Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases.
Current directions in autoimmunity 2006;9():74-94.
2005: Leigh Coultas; Philippe Bouillet; Kate L Loveland; Sarah J Meachem; Harris Perlman; Jerry M Adams; Andreas Strasser
Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis.
The EMBO journal 2005;24(22):3963-73.
2005: Philippe Bouillet; Mikara Robati; Mary L Bath; Andreas Strasser
Polycystic kidney disease prevented by transgenic RNA interference.
Cell death and differentiation 2005;12(7):831-3.
2005: Jack Hutcheson; John scatizzi; Emily Bickel; Nathaniel J Brown; Philippe Bouillet; Andreas Strasser; Harris Perlman
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis.
The Journal of experimental medicine 2005;201(12):1949-60.
2005: Ting-Ting Tan; Kurt Degenhardt; Deirdre A Nelson; Brian Beaudoin; Wilberto Nieves-Neira; Philippe Bouillet; Andreas Villunger; Jerry M Adams; Eileen White
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.
Cancer cell 2005;7(3):227-38.
2005: Jerry M Adams; David C S Huang; Andreas Strasser; S Willis; Lin Chen; Andrew Wei; Mark F Van Delft; Jamie I Fletcher; Hamsa Puthalakath; Junya Kuroda; Ewa M Michalak; Priscilla N Kelly; Philippe Bouillet; Andreas Villunger; Lorraine A O'Reilly; Mary L Bath; Darrin P Smith; Alexander Egle; Alan W Harris; Mark G Hinds; Peter M Colman; Suzanne Cory
Subversion of the Bcl-2 life/death switch in cancer development and therapy.
Cold Spring Harbor symposia on quantitative biology 2005;70():469-77.
2004: Marc Pellegrini; Philippe Bouillet; Mikara Robati; Gabrielle Belz; Gayle M Davey; Andreas Strasser
Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice.
The Journal of experimental medicine 2004;200(9):1189-95.
2004: Andreas Villunger; Vanessa S Marsden; Yifan Zhan; Miriam Erlacher; Andrew M Lew; Philippe Bouillet; Stuart P Berzins; Dale I Godfrey; William R Heath; Andreas Strasser
Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7052-7.
2004: Alexander Egle; Alan W Harris; Philippe Bouillet; Suzanne Cory
Bim is a suppressor of Myc-induced mouse B cell leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6164-9.
2004: Leigh Coultas; Philippe Bouillet; Edouard G Stanley; Thomas C Brodnicki; Jerry M Adams; Andreas Strasser
Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.
Molecular and cellular biology 2004;24(4):1570-81.
2003: Philippe Bouillet; Mikara Robati; Jerry M Adams; Andreas Strasser
Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration.
Journal of neuroscience research 2003;74(5):777-81.
2003: Anselm Enders; Philippe Bouillet; Hamsa Puthalakath; Yuekang Xu; David M Tarlinton; Andreas Strasser
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells.
The Journal of experimental medicine 2003;198(7):1119-26.
2003: Andreas Villunger; Clare Scott; Philippe Bouillet; Andreas Strasser
Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival.
Blood 2003;101(6):2393-400.
2002: Vanessa S Marsden; Liam O'Connor; Lorraine A O'Reilly; John Silke; Donald Metcalf; Paul G Ekert; David C S Huang; Francesco Cecconi; Keisuke Kuida; Kevin J Tomaselli; Sophie Roy; Don W Nicholson; David L Vaux; Philippe Bouillet; Jerry M Adams; Andreas Strasser
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.
Nature 2002;419(6907):634-7.
2002: Gayle M Davey; Christian Kurts; Jacques F A P Miller; Philippe Bouillet; Andreas Strasser; Andrew G Brooks; Francis R Carbone; William R Heath
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim.
The Journal of experimental medicine 2002;196(7):947-55.
2002: Philippe Bouillet; Andreas Strasser
BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.
Journal of cell science 2002;115(Pt 8):1567-74.
2002: Philippe Bouillet; Jared F Purton; Dale I Godfrey; Li-Chen Zhang; Leigh Coultas; Hamsa Puthalakath; Marc Pellegrini; Suzanne Cory; Jerry M Adams; Andreas Strasser
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes.
Nature 2002;415(6874):922-6.
2001: Philippe Bouillet; Suzanne Cory; Li-Chen Zhang; Andreas Strasser; Jerry M Adams
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim.
Developmental cell 2001;1(5):645-53.
2001: Philippe Bouillet; Li-Chen Zhang; D C Huang; GC Webb; C D K Bottema; P Shore; H J Eyre; G R Sutherland; Jerry M Adams
Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(2):163-8.
2000: Andreas Strasser; Hamsa Puthalakath; Philippe Bouillet; David C S Huang; L O'Connor; Lorraine A O'Reilly; L Cullen; Suzanne Cory; Jerry M Adams
The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control.
Annals of the New York Academy of Sciences 2000;917():541-8.
2000: Philippe Bouillet; David C S Huang; Lorraine A O'Reilly; Hamsa Puthalakath; L O'Connor; Suzanne Cory; Jerry M Adams; Andreas Strasser
The role of the pro-apoptotic Bcl-2 family member bim in physiological cell death.
Annals of the New York Academy of Sciences 2000;926():83-9.
1999: Philippe Bouillet; Donald Metcalf; David C S Huang; David M Tarlinton; T W Kay; F Köntgen; Jerry M Adams; Andreas Strasser
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
Science (New York, N.Y.) 1999;286(5445):1735-8.
1999: Jerry M Adams; David C S Huang; Hamsa Puthalakath; Philippe Bouillet; G Vairo; K Moriishi; George Hausmann; Lorraine A O'Reilly; K Newton; Sarah Ogilvy; Mary L Bath; Cristin G Print; Alan W Harris; Andreas Strasser; Suzanne Cory
Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins.
Cold Spring Harbor symposia on quantitative biology 1999;64():351-8.