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Hiroyuki Umegaki

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Oyun Khookhor; Hiroyuki Umegaki
The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system.
Hiroyuki Umegaki; Madoka Yanagawa; Toshio Hayashi; Hirotaka Nakshima; Hideki Nomura; Zen Nonogaki; Masafumi Kuzuya
Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly.
Hiroyuki Umegaki; Madoka Yanagawa; Masufumi Kuzuya; Hirotaka Nakashima; Zen Nonogaki; Yusuke Suzuki; Hidetoshi Endo
Cognitive impairments and functional declines in older adults at high risk for care needs.

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All Publications

2013: Oyun Khookhor; Hiroyuki Umegaki
The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system.
Neuro endocrinology letters 2013;34(1):58-61.
2013: Hiroyuki Umegaki; Madoka Yanagawa; Toshio Hayashi; Hirotaka Nakshima; Hideki Nomura; Zen Nonogaki; Masafumi Kuzuya
Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly.
Geriatrics & gerontology international 2013;13(1):28-34.
2013: Hiroyuki Umegaki; Madoka Yanagawa; Masufumi Kuzuya; Hirotaka Nakashima; Zen Nonogaki; Yusuke Suzuki; Hidetoshi Endo
Cognitive impairments and functional declines in older adults at high risk for care needs.
Geriatrics & gerontology international 2013;13(1):77-82.
2012: Naoko Kawano; Masafumi Kuzuya; Akiko Noda; Branko Aleksic; Kazutoshi Ebe; Tetsuya Iidaka; Kunihiro Iwamoto; Hiroyuki Umegaki; Norio Ozaki
Slower adaptation to driving simulator and simulator sickness in older adults.
Aging clinical and experimental research 2012;24(3):285-9.
2012: Hiroyuki Umegaki; Madoka Yanagawa; Hirotaka Nakashima; Zen Nonogaki; Yusuke Suzuki; Hidetoshi Endo
Dysphagia in older adults at high risk of requiring care.
Geriatrics & gerontology international 2012;12(2):359-61.
2012: Hiroyuki Umegaki; Atsushi Araki; Katsuya Iijima; Satoshi Iimuro; Hideki Ito; Yasuo Ohashi; Takashi Sakurai; Tomohiro Shinozaki
Risk factors associated with cognitive decline in the elderly with type 2 diabetes: pooled logistic analysis of a 6-year observation in the Japanese Elderly Diabetes Intervention Trial.
Geriatrics & gerontology international 2012;12 Suppl 1():110-6.
2012: Hiroyuki Umegaki; Atsushi Araki; Katsuya Iijima; Satoshi Iimuro; Hideki Ito; Yasuo Ohashi; Takashi Sakurai; Tomohiro Shinozaki
Risk factors associated with cognitive decline in the elderly with type 2 diabetes: baseline data analysis of the Japanese Elderly Diabetes Intervention Trial.
Geriatrics & gerontology international 2012;12 Suppl 1():103-9.
2012: Hiroyuki Umegaki
Neurocognitive dysfunction in old diabetes: management and treatment.
Advances in experimental medicine and biology 2012;771():465-70.
2012: Hiroyuki Umegaki
Neurodegeneration in diabetes mellitus.
Advances in experimental medicine and biology 2012;724():258-65.
2011: Akemi Hirano; Masafumi Kuzuya; Joji Onishi; Yusuke Suzuki; Nobutaro Ban; Hiroyuki Umegaki
Influence of regular exercise on subjective sense of burden and physical symptoms in community-dwelling caregivers of dementia patients: a randomized controlled trial.
Archives of gerontology and geriatrics 2011;53(2):e158-63.
2011: Hiroyuki Umegaki; Madoka Yanagawa; Hidetoshi Endo
Association of lower hemoglobin level with depressive mood in elderly women at high risk of requiring care.
Geriatrics & gerontology international 2011;11(3):262-6.
2011: Akemi Hirano; Yusuke Suzuki; Masafumi Kuzuya; Joji Onishi; Jun Hasegawa; Nobutaro Ban; Hiroyuki Umegaki
Association between the caregiver's burden and physical activity in community-dwelling caregivers of dementia patients.
Archives of gerontology and geriatrics 2011;52(3):295-8.
2010: Naoko Kawano; Hiroyuki Umegaki; Yusuke Suzuki; Sayaka Yamamoto; Nanaka Mogi; Akihisa Iguchi
Effects of educational background on verbal fluency task performance in older adults with Alzheimer's disease and mild cognitive impairment.
International psychogeriatrics / IPA 2010;22(6):995-1002.
2010: Hiroyuki Umegaki
Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration?
Age and ageing 2010;39(1):8-10.
2009: Hiroyuki Umegaki; Satoshi Iimuro; Atsushi Araki; Takashi Sakurai; Akihisa Iguchi; Yukio Yoshimura; Yasuo Ohashi; Hideki Ito
Association of higher carbohydrate intake with depressive mood in elderly diabetic women.
Nutritional neuroscience 2009;12(6):267-71.
2009: Hiroyuki Umegaki; Aki Yamamoto; Yusuke Suzuki; Akihisa Iguchi
Responses of hypothalamo-pituitary-adrenal axis to a cholinesterase inhibitor.
Neuroreport 2009;20(15):1366-70.
2009: Naoko Kawano; Taeko Makino; Yusuke Suzuki; Hiroyuki Umegaki
[Impact of driving cessation on daily transportation utility in elderly people with cognitive decline: a survey of patients in the memory clinic of an urban university hospital].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2009;46(5):420-7.
2009: Hiroyuki Umegaki; Yusuke Suzuki; Joji Ohnishi; Akihisa Iguchi
Changes in the perception of dementia in Japan.
International psychogeriatrics / IPA 2009;21(4):793-5.
2009: Toshio Hayashi; Seinosuke Kawashima; Hideki Itoh; Nobuhiro Yamada; Hirohito Sone; Hiroshi Watanabe; Yoshiyuki Hattori; Takashi Ohrui; Koutaro Yokote; Hideki Nomura; Hiroyuki Umegaki; Akihisa Iguchi
Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages.
Diabetes care 2009;32(7):1221-3.
2008: Hiroyuki Umegaki; George S Roth; Donald Ingram
Aging of the striatum: mechanisms and interventions.
Age (Dordrecht, Netherlands) 2008;30(4):251-61.
2008: Hiroyuki Umegaki; Akio Itoh; Yusuke Suzuki; Toshitaka Nabeshima
Discontinuation of donepezil for the treatment of Alzheimer's disease in geriatric practice.
International psychogeriatrics / IPA 2008;20(4):800-6.
2008: Hiroyuki Umegaki; Hajime Haimoto; Joji Ishikawa; Kazuomi Kario
Visceral fat contribution of insulin resistance in elderly people.
Journal of the American Geriatrics Society 2008;56(7):1373-5.
2008: Panayotis K Thanos; Michael Michaelides; Hiroyuki Umegaki; Nora D Volkow
D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats.
Synapse (New York, N.Y.) 2008;62(7):481-6.
2008: Hiroyuki Umegaki; Takahiko Kawamura; Nanaka Mogi; Toshitaka Umemura; Akio Kanai; Takahisa Sano
Glucose control levels, ischaemic brain lesions, and hyperinsulinaemia were associated with cognitive dysfunction in diabetic elderly.
Age and ageing 2008;37(4):458-61.
2008: Hiroyuki Umegaki; Satoshi Iimuro; Tetsuji Kaneko; Atsushi Araki; Takashi Sakurai; Yasuo Ohashi; Akihisa Iguchi; Hideki Ito
Factors associated with lower Mini Mental State Examination scores in elderly Japanese diabetes mellitus patients.
Neurobiology of aging 2008;29(7):1022-6.
2008: Toshio Hayashi; Seinosuke Kawashima; Hideki Itoh; Nobuhiro Yamada; Hirohito Sone; Hiroshi Watanabe; Yoshiyuki Hattori; Takashi Ohrui; Masashi Yoshizumi; Koutaro Yokote; Kiyoshi Kubota; Hideki Nomura; Hiroyuki Umegaki; Akihisa Iguchi
Importance of lipid levels in elderly diabetic individuals: baseline characteristics and 1-year survey of cardiovascular events.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(2):218-25.
2007: Naoko Kawano; Hiroyuki Umegaki; Nanaka Mogi; Sayaka Yamamoto; Yusuke Suzuki; Akihisa Iguchi
[An overview and prospect of demented outpatient care in a department of geriatric medicine: report based on statistical review of the memory clinic at the geriatric outpatient unit of the Nagoya University Hospital].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2007;44(5):611-8.
2007: Naoko Kawano; Hiroyuki Umegaki; Yusuke Suzuki; Sayaka Yamamoto; Nanaka Mogi; Akihisa Iguchi
[The delayed word recall task using ADAS-Jcog word booklet effectively divides patients with mild cognitive impairment from normal elderly people].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2007;44(4):490-6.
2007: Hiroyuki Umegaki; Joji Onishi; Yusuke Suzuki; Hidetoshi Endo; Akihisa Iguchi
Attitudes toward disclosing the diagnosis of dementia in Japan.
International psychogeriatrics / IPA 2007;19(2):253-65.
2007: Hiroyuki Umegaki; Yusuke Suzuki; Masafumi Kuzuya; Akihisa Iguchi
[Attitudes of Japanese general practitioners towards referrals of patients with dementia].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2007;44(1):102-6.
2007: Joji Onishi; Yusuke Suzuki; Hiroyuki Umegaki; Takashi Kawamura; Munehisa Imaizumi; Akihisa Iguchi
Which two questions of Mini-Mental State Examination (MMSE) should we start from?
Archives of gerontology and geriatrics 2007;44(1):43-8.
2006: Hiroyuki Umegaki; Yoko Yamaguchi; Kiichi Ishiwata; Donald Ingram; George S Roth; Akihisa Iguchi
Functional recovery of the striatal cholinergic system in aged rats by adenoviral vector-mediated gene transfer of dopamine D2 receptor.
Mechanisms of ageing and development 2006;127(10):813-5.
2006: Hiroyuki Umegaki; Aki Yamamoto; Yusuke Suzuki; Akihisa Iguchi
Stimulation of the hippocampal glutamate receptor systems induces stress-like responses.
Neuro endocrinology letters 2006;27(3):339-43.
2006: Mari Suzuki; Hiroyuki Umegaki; Satsuki Ieda; Nanaka Mogi; Akihisa Iguchi
Factors associated with cognitive impairment in elderly patients with diabetes mellitus.
Journal of the American Geriatrics Society 2006;54(3):558-9.
2006: Joji Onishi; Yusuke Suzuki; Hiroyuki Umegaki; Hidetoshi Endo; Takashi Kawamura; Akihisa Iguchi
A comparison of depressive mood of older adults in a community, nursing homes, and a geriatric hospital: factor analysis of Geriatric Depression Scale.
Journal of geriatric psychiatry and neurology 2006;19(1):26-31.
2006: Joji Onishi; Yusuke Suzuki; Hiroyuki Umegaki; Hidetoshi Endo; Takashi Kawamura; Munehisa Imaizumi; Akihisa Iguchi
Behavioral, psychological and physical symptoms in group homes for older adults with dementia.
International psychogeriatrics / IPA 2006;18(1):75-86.
2006: Hiroyuki Umegaki; Yoko Yamaguchi; Yusuke Suzuki; Akihisa Iguchi
Microdialysis measurement of acetylcholine in rat hippocampus during severe insulin-induced hypoglycemia.
Neuro endocrinology letters 2006;27(1-2):128-32.
2006: Hiroshige Fujishiro; Hiroyuki Umegaki; Daisuke Isojima; Hiroyasu Akatsu; Akihisa Iguchi; Kenji Kosaka
Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies.
Acta neuropathologica 2006;111(2):109-14.
2006: Hiroyuki Umegaki; Akihisa Iguchi
[Target of glycemic control of elderly diabetes mellitus patients].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(1):70-3.
2005: Hiroshige Fujishiro; Hiroyuki Umegaki; Yusuke Suzuki; Shinobu Oohara-Kurotani; Yoko Yamaguchi; Akihisa Iguchi
Dopamine D2 receptor plays a role in memory function: implications of dopamine-acetylcholine interaction in the ventral hippocampus.
Psychopharmacology 2005;182(2):253-61.
2005: Joji Onishi; Yusuke Suzuki; Hiroyuki Umegaki; Akira Nakamura; Hidetoshi Endo; Akihisa Iguchi
Influence of behavioral and psychological symptoms of dementia (BPSD) and environment of care on caregivers' burden.
Archives of gerontology and geriatrics 2005;41(2):159-68.
2005: Shadi Adeli-Rankouhi; Hiroyuki Umegaki; Waner Zhu; Yusuke Suzuki; Shinobu Kurotani-Ohara; Satsuki Ieda; Akihisa Iguchi
The entorhinal cortex regulates blood glucose level in response to microinjection of neostigmine into the hippocampus.
Neuro endocrinology letters 2005;26(3):225-30.
2005: Panayotis K Thanos; Seth N Rivera; Katrina Weaver; David K Grandy; Marcelo Rubinstein; Hiroyuki Umegaki; Gene-Jack Wang; Robert Hitzemann; Nora D Volkow
Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking.
Life sciences 2005;77(2):130-9.
2005: Hiroshige Fujishiro; Hiroyuki Umegaki; Yusuke Suzuki; Akira Nakamura; Yoshihisa Hirakawa; Akihisa Iguchi
[Awareness of dementia in older adults attending dementia-prevention programs in community healthcare centers].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2005;42(3):340-5.
2004: Hidetoshi Endo; Shinichi Oshima; Hisayuki Miura; Jyoji Onishi; Hiroyuki Umegaki; Yusuke Suzuki; Akihisa Iguchi
[Present status of geriatric care in the world].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2004;93(12):2599-602.
2004: Yusuke Suzuki; Sayaka Yamamoto; Hiroyuki Umegaki; Joji Onishi; Nanaka Mogi; Hiroshige Fujishiro; Akihisa Iguchi
Smell identification test as an indicator for cognitive impairment in Alzheimer's disease.
International journal of geriatric psychiatry 2004;19(8):727-33.
2004: Joji Onishi; Hiroyuki Umegaki; Yusuke Suzuki; Katsuhiko Uemura; Masafumi Kuzuya; Akihisa Iguchi
The relationship between functional disability and depressive mood in Japanese older adult inpatients.
Journal of geriatric psychiatry and neurology 2004;17(2):93-8.
2004: Panayotis K Thanos; Nicholas B Taintor; Seth N Rivera; Hiroyuki Umegaki; Hiroyuki Ikari; George Roth; Donald Ingram; Robert Hitzemann; Joanna S Fowler; S John Gatley; Gene-Jack Wang; Nora D Volkow
DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking.
Alcoholism, clinical and experimental research 2004;28(5):720-8.
2004: Hiroyuki Umegaki
[Clinical global assessment].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 4():42-4.
2004: Sayaka Yamamoto; Nanaka Mogi; Hiroyuki Umegaki; Yusuke Suzuki; Fujiko Ando; Hiroshi Shimokata; Akihisa Iguchi
The clock drawing test as a valid screening method for mild cognitive impairment.
Dementia and geriatric cognitive disorders 2004;18(2):172-9.
2004: Nanaka Mogi; Hiroyuki Umegaki; Ayako Hattori; Noriki Maeda; Hisayuki Miura; Masafumi Kuzuya; Hiroshi Shimokata; Fujiko Ando; Hideki Ito; Akihisa Iguchi
Cognitive function in Japanese elderly with type 2 diabetes mellitus.
Journal of diabetes and its complications 2004;18(1):42-6.
2003: Shinobu Kurotani; Hiroyuki Umegaki; Kiichi Ishiwata; Yusuke Suzuki; Akihisa Iguchi
The age-associated changes of dopamine-acetylcholine interaction in the striatum.
Experimental gerontology 2003;38(9):1009-13.
2003: Hiroyuki Umegaki; Waner Zhu; A Nakamura; Yusuke Suzuki; M Takada; H Endo; Akihisa Iguchi
Involvement of the entorhinal cortex in the stress response to immobilization, but not to insulin-induced hypoglycaemia.
Journal of neuroendocrinology 2003;15(3):237-41.
2003: Waner Zhu; Hiroyuki Umegaki; Tadashi Shinkai; Shinobu Kurotani; Yusuke Suzuki; Hidetoshi Endo; Akihisa Iguchi
Different glial reactions to hippocampal stab wounds in young adult and aged rats.
The journals of gerontology. Series A, Biological sciences and medical sciences 2003;58(2):117-22.
2003: Hiroyuki Umegaki; Kiichi Ishiwata; Osamu Ogawa; Donald Ingram; George S Roth; Keiichi Oda; Shinobu Kurotani; K Kawamura; W F Wang; Hiroyuki Ikari; Michio Senda; Akihisa Iguchi
Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study.
Neuroscience 2003;121(2):479-86.
2002: Michiteru Kodama; Hiroyuki Umegaki; Nanaka Mogi; Akihisa Iguchi; Akinori Takeda
[An elderly case with sarcoidosis whose symptom of dementia was effectively treated by steroid].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2002;39(6):648-53.
2002: Hiroyuki Umegaki; Kiichi Ishiwata; Osamu Ogawa; Donald Ingram; George S Roth; Juri Yoshimura; Keiichi Oda; Hisako Matsui-Hirai; Hiroyuki Ikari; Akihisa Iguchi; Michio Senda
In vivo assessment of adenoviral vector-mediated gene expression of dopamine D(2) receptors in the rat striatum by positron emission tomography.
Synapse (New York, N.Y.) 2002;43(3):195-200.
2002: Hiroyuki Umegaki; Hideki Nomura; Akira Nakamura; Fujiko Ando; Hiroshi Shimokata; Sayaka Yamamoto; Masahumi Kuzuya; Akihisa Iguchi
[Relation between destination on discharge in the elderly patients and comprehensive geriatric assessment at admission in the ward of the Geriatric Department of University Hospital].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2002;39(1):75-82.
2001: A Nakamura; Yusuke Suzuki; Hiroyuki Umegaki; Hiroyuki Ikari; T Tajima; Hidetoshi Endo; Akihisa Iguchi
Dietary restriction of choline reduces hippocampal acetylcholine release in rats: in vivo microdialysis study.
Brain research bulletin 2001;56(6):593-7.
2001: Waner Zhu; Hiroyuki Umegaki; Yusuke Suzuki; Hideki Miura; Akihisa Iguchi
Involvement of the bed nucleus of the stria terminalis in hippocampal cholinergic system-mediated activation of the hypothalamo--pituitary--adrenocortical axis in rats.
Brain research 2001;916(1-2):101-6.
2001: Panayotis K Thanos; Nora D Volkow; Paul Freimuth; Hiroyuki Umegaki; Hiroyuki Ikari; G Roth; Donald Ingram; Robert Hitzemann
Overexpression of dopamine D2 receptors reduces alcohol self-administration.
Journal of neurochemistry 2001;78(5):1094-103.
2001: Nanaka Mogi; Ayako Hattori; C Ushida; Hiroyuki Umegaki; H Miura; Akihisa Iguchi
[Cognitive function and brain atrophy in elderly type 2 diabetic patients in comparison with non-diabetic elderly subjects].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2001;38(3):388-92.
2001: Waner Zhu; Hiroyuki Umegaki; Juri Yoshimura; N Tamaya; Yusuke Suzuki; Hideki Miura; Akihisa Iguchi
The elevation of plasma adrenocorticotrophic hormone and expression of c-Fos in hypothalamic paraventricular nucleus by microinjection of neostigmine into the hippocampus in rats: comparison with acute stress responses.
Brain research 2001;892(2):391-5.
2001: Hiroyuki Umegaki; J Munoz; RC Meyer; Edward L Spangler; Juri Yoshimura; Hiroyuki Ikari; Akihisa Iguchi; Donald Ingram
Involvement of dopamine D(2) receptors in complex maze learning and acetylcholine release in ventral hippocampus of rats.
Neuroscience 2001;103(1):27-33.
2000: Hiroyuki Umegaki
[The changes of peripheral-central nervous system interaction in Alzheimer's disease].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2000;37(12):966-9.
2000: Hiroyuki Umegaki; N Tamaya; T Shinkai; Akihisa Iguchi
The metabolism of plasma glucose and catecholamines in Alzheimer's disease.
Experimental gerontology 2000;35(9-10):1373-82.
2000: Osamu Ogawa; Hiroyuki Umegaki; Daigo Sumi; Toshio Hayashi; A Nakamura; Navin Kumar Thakur; Juri Yoshimura; Hidetoshi Endo; Akihisa Iguchi
Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells.
European journal of pharmacology 2000;408(2):137-41.
2000: Hiroyuki Umegaki; Hiroyuki Ikari; H Nakahata; Hidetoshi Endo; Yusuke Suzuki; Osamu Ogawa; A Nakamura; Takayuki Yamamoto; Akihisa Iguchi
Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study.
Brain research 2000;881(2):241-3.
2000: Donald Ingram; George S Roth; Hiroyuki Umegaki; Hiroyuki Ikari
Development of an adenoviral vector for intracerebral delivery of the dopamine D(2) receptor.
Mechanisms of ageing and development 2000;116(2-3):77-93.
2000: Masahumi Kuzuya; H Endo; Hiroyuki Umegaki; M Nakao; T Niwa; T Kumagai; Yumi Ushida; T Nabeshima; Akihisa Iguchi
[Factors influencing noncompliance with medication regimens in the elderly].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2000;37(5):363-70.
2000: Osamu Ogawa; Hiroyuki Umegaki; Kiichi Ishiwata; Y Asai; Hiroyuki Ikari; Keiichi Oda; H Toyama; Donald Ingram; George S Roth; Akihisa Iguchi; Michio Senda
In vivo imaging of adenovirus-mediated over-expression of dopamine D2 receptors in rat striatum by positron emission tomography.
Neuroreport 2000;11(4):743-8.
2000: Hiroyuki Umegaki; Hiroyuki Ikari; H Nakahata; Juri Yoshimura; Hidetoshi Endo; Takayuki Yamamoto; Akihisa Iguchi
Low plasma epinephrine in elderly female subjects of dementia of Alzheimer type.
Brain research 2000;858(1):67-70.
1999: Hiroyuki Ikari; Hiroyuki Umegaki; Akihisa Iguchi
[Gene therapy to treat Parkinson's disease].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1999;36(2):103-9.
1998: Donald Ingram; Hiroyuki Ikari; Hiroyuki Umegaki; JM Chernak; George S Roth
Application of gene therapy to treat age-related loss of dopamine D2 receptor.
Experimental gerontology 1998;33(7-8):793-804.
1998: A Hattori; Y Luo; Hiroyuki Umegaki; J Munoz; George S Roth
Intrastriatal injection of dopamine results in DNA damage and apoptosis in rats.
Neuroreport 1998;9(11):2569-72.
1997: Hiroyuki Umegaki; JM Chernak; Hiroyuki Ikari; George S Roth; Donald Ingram
Rotational behavior produced by adenovirus-mediated gene transfer of dopamine D2 receptor into rat striatum.
Neuroreport 1997;8(16):3553-8.
1997: Kiyofumi Yamada; Hiroyuki Umegaki; I Maezawa; Akihisa Iguchi; T Kameyama; Toshitaka Nabeshima
Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells.
Brain research bulletin 1997;43(6):573-7.
1996: Hiroyuki Umegaki; K Yamada; Michitaka Naito; T Kameyama; Akihisa Iguchi; T Nabeshima
Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore.
Biochemical pharmacology 1996;52(6):911-6.
1995: K Yamada; K Kono; Hiroyuki Umegaki; K Yamada; Akihisa Iguchi; T Fukatsu; N Nakashima; H Nishiwaki; Y Shimada; Y Sugita
Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia.
Neuroscience letters 1995;186(2-3):219-21.
1995: Michitaka Naito; Hiroyuki Umegaki; Akihisa Iguchi
Protective effects of probucol against glutamate-induced cytotoxicity in neuronal cell line PC12.
Neuroscience letters 1995;186(2-3):211-3.