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Takashi Umehara

Research Profile

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Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

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Saccharomyces cerevisiae

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TOP 3
Hideaki Niwa; Noboru Ohsawa; Mikako Shirouzu; Yuri Tomabechi; Mitsutoshi Toyama; Takashi Umehara; Noriko Handa; Tomoya Hirano; Keiko Honda; Hiroyuki Kagechika; Shigeyuki Yokoyama
Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives.
Masatoshi Wakamori; Takashi Umehara; Shigeyuki Yokoyama
A tandem insertion vector for large-scale preparation of nucleosomal DNA.
Takahito Mukai; Kazumasa Ohtake; Jiro Adachi; Akiko Hayashi; Nobumasa Hino; Takatsugu Kobayashi; Aya Sato; Mikako Shirouzu; Takashi Umehara; Minoru Wakamori; Tatsuo Yanagisawa; Shigeyuki Yokoyama; Kensaku Sakamoto
Genetic-code evolution for protein synthesis with non-natural amino acids.

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All Publications

2013: Hideaki Niwa; Noboru Ohsawa; Mikako Shirouzu; Yuri Tomabechi; Mitsutoshi Toyama; Takashi Umehara; Noriko Handa; Tomoya Hirano; Keiko Honda; Hiroyuki Kagechika; Shigeyuki Yokoyama
Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives.
Acta crystallographica. Section D, Biological crystallography 2013;69(Pt 4):595-602.
2012: Masatoshi Wakamori; Takashi Umehara; Shigeyuki Yokoyama
A tandem insertion vector for large-scale preparation of nucleosomal DNA.
Analytical biochemistry 2012;423(1):184-6.
2011: Takahito Mukai; Kazumasa Ohtake; Jiro Adachi; Akiko Hayashi; Nobumasa Hino; Takatsugu Kobayashi; Aya Sato; Mikako Shirouzu; Takashi Umehara; Minoru Wakamori; Tatsuo Yanagisawa; Shigeyuki Yokoyama; Kensaku Sakamoto
Genetic-code evolution for protein synthesis with non-natural amino acids.
Biochemical and biophysical research communications 2011;411(4):757-61.
2011: Shin Sato; Takashi Umehara; Nobumasa Hino; Shinya Mimasu; Kensaku Sakamoto; Aya Sato; Shigeyuki Yokoyama
Crystallographic study of a site-specifically cross-linked protein complex with a genetically incorporated photoreactive amino acid.
Biochemistry 2011;50(2):250-7.
2010: Masatoshi Wakamori; Takashi Umehara; Shigeyuki Yokoyama
A series of bacterial co-expression vectors with rare-cutter recognition sequences.
Protein expression and purification 2010;74(1):88-98.
2010: Takashi Umehara; Yoshihiro Nakamura; Minoru Wakamori; Keiko Ozato; Shigeyuki Yokoyama; Balasundaram Padmanabhan
Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2.
FEBS letters 2010;584(18):3901-8.
2010: Fahu He; Takashi Umehara; Kohei Saito; Takushi Harada; Satoru Watanabe; Takashi Yabuki; Takanori Kigawa; Mari Takahashi; Kanako Kuwasako; Kengo Tsuda; Takayoshi Matsuda; Masaaki Aoki; Eiko Seki; Naohiro Kobayashi; Peter Güntert; Shigeyuki Yokoyama; Yutaka Muto
Structural insight into the zinc finger CW domain as a histone modification reader.
Structure (London, England : 1993) 2010;18(9):1127-39.
2010: Naoya Tochio; Takashi Umehara; Yoshiko Munemasa; Toru Suzuki; Shin Sato; Kengo Tsuda; Seizo Koshiba; Takanori Kigawa; Ryozo Nagai; Shigeyuki Yokoyama
Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain.
Journal of molecular biology 2010;401(1):97-114.
2010: Shinya Mimasu; Naoki Umezawa; Shin Sato; Tsunehiko Higuchi; Takashi Umehara; Shigeyuki Yokoyama
Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1 .
Biochemistry 2010;49(30):6494-503.
2010: Atsushi Shimada; Kazunori Takano; Mikako Shirouzu; Kyoko Hanawa-Suetsugu; Takaho Terada; Kiminori Toyooka; Takashi Umehara; Masaki Yamamoto; Shigeyuki Yokoyama; Shiro Suetsugu
Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II.
FEBS letters 2010;584(6):1111-8.
2010: Takashi Umehara; Yoshihiro Nakamura; Moon Kyoo Jang; Kazumi Nakano; Akiko Tanaka; Keiko Ozato; Balasundaram Padmanabhan; Shigeyuki Yokoyama
Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain.
The Journal of biological chemistry 2010;285(10):7610-8.
2007: Yoshihiro Nakamura; Takashi Umehara; Akiko Tanaka; Masami Horikoshi; Balasundaram Padmanabhan; Shigeyuki Yokoyama
Structural basis for the recognition between the regulatory particles Nas6 and Rpt3 of the yeast 26S proteasome.
Biochemical and biophysical research communications 2007;359(3):503-9.
2007: Fahu He; Takashi Umehara; Kengo Tsuda; Makoto Inoue; Takanori Kigawa; Takayoshi Matsuda; Takashi Yabuki; Masaaki Aoki; Eiko Seki; Takaho Terada; Mikako Shirouzu; Akiko Tanaka; Sumio Sugano; Yutaka Muto; Shigeyuki Yokoyama
Solution structure of the zinc finger HIT domain in protein FON.
Protein science : a publication of the Protein Society 2007;16(8):1577-87.
2007: Takashi Umehara; Masatoshi Wakamori; Akiko Tanaka; Balasundaram Padmanabhan; Shigeyuki Yokoyama
Purification, crystallization and preliminary X-ray diffraction of the C-terminal bromodomain from human BRD2.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 7):613-5.
2007: Yoshihiro Nakamura; Takashi Umehara; Hiroaki Hamana; Yoshihide Hayashizaki; Makoto Inoue; Takanori Kigawa; Mikako Shirouzu; Takaho Terada; Akiko Tanaka; Balasundaram Padmanabhan; Shigeyuki Yokoyama
Crystal structure analysis of the PHD domain of the transcription co-activator Pygopus.
Journal of molecular biology 2007;370(1):80-92.
2007: Misao Yoneyama; Naoya Tochio; Takashi Umehara; Seizo Koshiba; Makoto Inoue; Takashi Yabuki; Masaaki Aoki; Eiko Seki; Takayoshi Matsuda; Satoru Watanabe; Yasuko Tomo; Yuji Nishimura; Takushi Harada; Takaho Terada; Mikako Shirouzu; Yoshihide Hayashizaki; Osamu Ohara; Akiko Tanaka; Takanori Kigawa; Shigeyuki Yokoyama
Structural and functional differences of SWIRM domain subtypes.
Journal of molecular biology 2007;369(1):222-38.
2007: Yoshihiro Nakamura; Takashi Umehara; Akiko Tanaka; Masami Horikoshi; Balasundaram Padmanabhan; Shigeyuki Yokoyama
Purification, crystallization and preliminary X-ray diffraction analysis of the non-ATPase subunit Nas6 in complex with the ATPase subunit Rpt3 of the 26S proteasome from Saccharomyces cerevisiae.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 3):190-2.
2007: Yoshihiro Nakamura; Takashi Umehara; Kazumi Nakano; Moon Kyoo Jang; Mikako Shirouzu; Satoshi Morita; Hiroko Uda-Tochio; Hiroaki Hamana; Takaho Terada; Naruhiko Adachi; Takehisa Matsumoto; Akiko Tanaka; Masami Horikoshi; Keiko Ozato; Balasundaram Padmanabhan; Shigeyuki Yokoyama
Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4.
The Journal of biological chemistry 2007;282(6):4193-201.
2007: Yoshihiro Nakamura; Kazumi Nakano; Takashi Umehara; Mayumi Kimura; Yoshihide Hayashizaki; Akiko Tanaka; Masami Horikoshi; Balasundaram Padmanabhan; Shigeyuki Yokoyama
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
Structure (London, England : 1993) 2007;15(2):179-89.
2007: Kazuko Matsubara; Norihiko Sano; Takashi Umehara; Masami Horikoshi
Global analysis of functional surfaces of core histones with comprehensive point mutants.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(1):13-33.
2006: Naoya Tochio; Takashi Umehara; Seizo Koshiba; Makoto Inoue; Takashi Yabuki; Masaaki Aoki; Eiko Seki; Satoru Watanabe; Yasuko Tomo; Masaru Hanada; Masaomi Ikari; Miyuki Sato; Takaho Terada; Takahiro Nagase; Osamu Ohara; Mikako Shirouzu; Akiko Tanaka; Takanori Kigawa; Shigeyuki Yokoyama
Solution structure of the SWIRM domain of human histone demethylase LSD1.
Structure (London, England : 1993) 2006;14(3):457-68.
2005: Balasundaram Padmanabhan; Kazuhiro Kataoka; Takashi Umehara; Naruhiko Adachi; Shigeyuki Yokoyama; Masami Horikoshi
Structural similarity between histone chaperone Cia1p/Asf1p and DNA-binding protein NF-kappaB.
Journal of biochemistry 2005;138(6):821-9.
2005: Takashi Umehara; Yumi Otta; Keiko Tsuganezawa; Takehisa Matsumoto; Akiko Tanaka; Masami Horikoshi; Balasundaram Padmanabhan; Shigeyuki Yokoyama
Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 11):971-3.
2003: Takashi Umehara; Masami Horikoshi
Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis.
The Journal of biological chemistry 2003;278(37):35660-7.
2002: Takashi Umehara; Takahiko Chimura; Natsuko Ichikawa; Masami Horikoshi
Polyanionic stretch-deleted histone chaperone cia1/Asf1p is functional both in vivo and in vitro.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(1):59-73.
2001: M Yamaki; Takashi Umehara; Takahiko Chimura; Masami Horikoshi
Cell death with predominant apoptotic features in Saccharomyces cerevisiae mediated by deletion of the histone chaperone ASF1/CIA1.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(12):1043-54.