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Kazuhiko Umesono

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Shinichiro Takezawa; Atsushi Yokoyama; Maiko Okada; Ryoji Fujiki; Aya Iriyama; Yasuo Yanagi; Hiroaki Ito; Ichiro Takada; Masahiko Kishimoto; Atsushi Miyajima; Ken-ichi Takeyama; Kazuhiko Umesono; Hirochika Kitagawa; Shigeaki Kato
A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function.
Hidesato Ogawa; Ruth T Yu; Tokuko Haraguchi; Yasushi Hiraoka; Yoshihiro Nakatani; Ken-ichirou Morohashi; Kazuhiko Umesono
Nuclear structure-associated TIF2 recruits glucocorticoid receptor and its target DNA.
Hiroyasu Inoue; Xiao Fan Jiang; Takahiro Katayama; Shiho Osada; Kazuhiko Umesono; Shobu Namura
Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice.

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All Publications

2007: Shinichiro Takezawa; Atsushi Yokoyama; Maiko Okada; Ryoji Fujiki; Aya Iriyama; Yasuo Yanagi; Hiroaki Ito; Ichiro Takada; Masahiko Kishimoto; Atsushi Miyajima; Ken-ichi Takeyama; Kazuhiko Umesono; Hirochika Kitagawa; Shigeaki Kato
A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function.
The EMBO journal 2007;26(3):764-74.
2004: Hidesato Ogawa; Ruth T Yu; Tokuko Haraguchi; Yasushi Hiraoka; Yoshihiro Nakatani; Ken-ichirou Morohashi; Kazuhiko Umesono
Nuclear structure-associated TIF2 recruits glucocorticoid receptor and its target DNA.
Biochemical and biophysical research communications 2004;320(1):218-25.
2003: Hiroyasu Inoue; Xiao Fan Jiang; Takahiro Katayama; Shiho Osada; Kazuhiko Umesono; Shobu Namura
Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice.
Neuroscience letters 2003;352(3):203-6.
2003: Taiga Suzuki; Megumi Kasahara; Hidefumi Yoshioka; Ken-ichirou Morohashi; Kazuhiko Umesono
LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1.
Molecular and cellular biology 2003;23(1):238-49.
2002: Taiga Suzuki; Megumi Kasahara; Hidefumi Yoshioka; Kazuhiko Umesono; Ken-ichirou Morohashi
LXXLL motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1.
Endocrine research 2002;28(4):537.
2002: Tetsuya Koide; Kazuhiko Umesono; Chikara Hashimoto
When does the anterior endomesderm meet the anterior-most neuroectoderm during Xenopus gastrulation?
The International journal of developmental biology 2002;46(6):777-83.
2001: T Suzuki; Hiroshi Kawasaki; Ruth T Yu; H Ueda; Kazuhiko Umesono
Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12403-8.
2001: T Koide; Michael Downes; R A Chandraratna; B Blumberg; Kazuhiko Umesono
Active repression of RAR signaling is required for head formation.
Genes & development 2001;15(16):2111-21.
2000: Felix Grün; Y Hirose; S Kawauchi; T Ogura; Kazuhiko Umesono
Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia during development.
The Journal of biological chemistry 2000;275(52):41210-8.
2000: M Kobayashi; Ruth T Yu; K Yasuda; Kazuhiko Umesono
Cell-type-specific regulation of the retinoic acid receptor mediated by the orphan nuclear receptor TLX.
Molecular and cellular biology 2000;20(23):8731-9.
2000: Ken-ichirou Morohashi; Tokuo Mukai; Ken Kawabe; Hirofumi Mizusaki; S Ishiharal; Kazuhiko Umesono; Kaname Kawajiri
Adrenocortical and gonadal differentiation regulated by transcription factors, Ad4BP/SF-1 (NR5A1) and Dax-I (NROB1).
Endocrine research 2000;26(4):953.
2000: Hiroyasu Inoue; Tadashi Tanabe; Kazuhiko Umesono
Feedback control of cyclooxygenase-2 expression through PPARgamma.
The Journal of biological chemistry 2000;275(36):28028-32.
2000: Yuka Fukui; S Masui; S Osada; Kazuhiko Umesono; Kiyoto Motojima
A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.
Diabetes 2000;49(5):759-67.
2000: Ichiro Takada; Ruth T Yu; H Eric Xu; Millard H Lambert; Valerie G Montana; Steven A Kliewer; Ronald M Evans; Kazuhiko Umesono
Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype.
Molecular endocrinology (Baltimore, Md.) 2000;14(5):733-40.
2000: Ruth T Yu; M Y Chiang; T Tanabe; Masayuki Kobayashi; K Yasuda; Ronald M Evans; Kazuhiko Umesono
The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2621-5.
1999: T Momose; A Tonegawa; Jun K Takeuchi; H Ogawa; Kazuhiko Umesono; Kunio Yasuda
Efficient targeting of gene expression in chick embryos by microelectroporation.
Development, growth & differentiation 1999;41(3):335-44.
1999: M Kobayashi; Shinichiro Takezawa; K Hara; Ruth T Yu; Yoshihiko Umesono; Kiyokazu Agata; M Taniwaki; K Yasuda; Kazuhiko Umesono
Identification of a photoreceptor cell-specific nuclear receptor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):4814-9.
1999: Hiroyasu Inoue; Kazuhiko Umesono; T Nishimori; Y Hirata; Tadashi Tanabe
Glucocorticoid-mediated suppression of the promoter activity of the cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells.
Biochemical and biophysical research communications 1999;254(2):292-8.
1999: S Inouye; Kazuhiko Umesono; F I Tsuji
Special properties of green fluorescent protein-S65A.
Methods in enzymology 1999;302():444-9.
1998: Kazuhiko Umesono
[Endocrine signaling system mediated by nuclear receptors].
Nihon rinsho. Japanese journal of clinical medicine 1998;56(7):1693-8.
1998: B Blumberg; H. Kang; J Bolado; Hongwu Chen; A G Craig; Tanya A Moreno; Kazuhiko Umesono; Thomas Perlmann; E M De Robertis; Ronald M Evans
BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites.
Genes & development 1998;12(9):1269-77.
1996: T Perlmann; Kazuhiko Umesono; P N Rangarajan; B M Forman; Ronald M Evans
Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors.
Molecular endocrinology (Baltimore, Md.) 1996;10(8):958-66.
1996: J D Chen; Kazuhiko Umesono; Ronald M Evans
SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7567-71.
1995: David J Mangelsdorf; Carl S Thummel; M Beato; P Herrlich; G Schütz; Kazuhiko Umesono; B Blumberg; P Kastner; M Mark; P Chambon; Ronald M Evans
The nuclear receptor superfamily: the second decade.
Cell 1995;83(6):835-9.
1995: H Ogawa; S Inouye; F I Tsuji; K Yasuda; Kazuhiko Umesono
Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11899-903.
1995: B M Forman; Kazuhiko Umesono; J Chen; Ronald M Evans
Unique response pathways are established by allosteric interactions among nuclear hormone receptors.
Cell 1995;81(4):541-50.
1995: P J Willy; Kazuhiko Umesono; Estelita S Ong; Ronald M Evans; Richard A Heyman; David J Mangelsdorf
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
Genes & development 1995;9(9):1033-45.
1994: R T Yu; Michael McKeown; Ronald M Evans; Kazuhiko Umesono
Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx.
Nature 1994;370(6488):375-9.
1994: Steven A Kliewer; B M Forman; B Blumberg; Estelita S Ong; U Borgmeyer; David J Mangelsdorf; Kazuhiko Umesono; Ronald M Evans
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7355-9.
1993: T Perlmann; P N Rangarajan; Kazuhiko Umesono; Ronald M Evans
Determinants for selective RAR and TR recognition of direct repeat HREs.
Genes & development 1993;7(7B):1411-22.
1993: K Damm; R A Heyman; Kazuhiko Umesono; Ronald M Evans
Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2989-93.
1993: David J Mangelsdorf; Steven A Kliewer; A Kakizuka; Kazuhiko Umesono; Ronald M Evans
Retinoid receptors.
Recent progress in hormone research 1993;48():99-121.
1992: P N Rangarajan; Kazuhiko Umesono; Ronald M Evans
Modulation of glucocorticoid receptor function by protein kinase A.
Molecular endocrinology (Baltimore, Md.) 1992;6(9):1451-7.
1992: Steven A Kliewer; Kazuhiko Umesono; Daniel J Noonan; R A Heyman; Ronald M Evans
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.
Nature 1992;358(6389):771-4.
1992: Peter Ghazal; C DeMattei; E Giulietti; Steven A Kliewer; Kazuhiko Umesono; Ronald M Evans
Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7630-4.
1992: Steven A Kliewer; Kazuhiko Umesono; R A Heyman; David J Mangelsdorf; J A Dyck; Ronald M Evans
Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1448-52.
1992: Steven A Kliewer; Kazuhiko Umesono; David J Mangelsdorf; Ronald M Evans
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.
Nature 1992;355(6359):446-9.
1991: A Kakizuka; W H Miller; Kazuhiko Umesono; RP Warrell; S R Frankel; Vundavalli Murty; Ethan Dmitrovsky; Ronald M Evans
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML.
Cell 1991;66(4):663-74.
1991: David J Mangelsdorf; Kazuhiko Umesono; Steven A Kliewer; U Borgmeyer; Estelita S Ong; Ronald M Evans
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
Cell 1991;66(3):555-61.
1991: Kazuhiko Umesono; K K Murakami; C C Thompson; Ronald M Evans
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors.
Cell 1991;65(7):1255-66.
1990: T Ishikawa; Kazuhiko Umesono; David J Mangelsdorf; Hiroyuki Aburatani; B Z Stanger; Y Shibasaki; M Imawari; Ronald M Evans; F Takaku
A functional retinoic acid receptor encoded by the gene on human chromosome 12.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):837-44.
1990: R Schüle; Kazuhiko Umesono; David J Mangelsdorf; J Bolado; J W Pike; Ronald M Evans
Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene.
Cell 1990;61(3):497-504.
1989: Kazuhiko Umesono; Ronald M Evans
Determinants of target gene specificity for steroid/thyroid hormone receptors.
Cell 1989;57(7):1139-46.
1989: A E Oro; Kazuhiko Umesono; Ronald M Evans
Steroid hormone receptor homologs in development.
Development (Cambridge, England) 1989;107 Suppl():133-40.
1988: Kazuhiko Umesono; V Giguere; C K Glass; M G Rosenfeld; Ronald M Evans
Retinoic acid and thyroid hormone induce gene expression through a common responsive element.
Nature 1988;336(6196):262-5.