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Dale Umetsu

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L A Albacker; D Bedoret; Gordon J Freeman; W-L Lee; S Monahan; Dale T Umetsu; S E Umetsu; S Yu; Rosemarie H Dekruyff
TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells.
Stephanie Jemielity; Wenhui Li; Sheena Monahan; Dale T Umetsu; Jinyize J Wang; Asim A Ahmed; Xia Bu; Ying Kai Chan; Rosemarie H Dekruyff; Michael Farzan; Gordon J Freeman; Hyeryun Choe
TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.
Mike Recher; Michela Rizzini; Dale T Umetsu; Jolan E Walter; Hermann Eibel; Ari J Fried; Francesco Frugoni; Silvia Giliani; Christoph Hess; Hye Young Kim; Michel J Massaad; Divij Mathew; Luigi D Notarangelo; Raif S Geha
Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia.

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2013: L A Albacker; D Bedoret; Gordon J Freeman; W-L Lee; S Monahan; Dale T Umetsu; S E Umetsu; S Yu; Rosemarie H Dekruyff
TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells.
Mucosal immunology 2013;6(3):580-90.
2013: Stephanie Jemielity; Wenhui Li; Sheena Monahan; Dale T Umetsu; Jinyize J Wang; Asim A Ahmed; Xia Bu; Ying Kai Chan; Rosemarie H Dekruyff; Michael Farzan; Gordon J Freeman; Hyeryun Choe
TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.
PLoS pathogens 2013;9(3):e1003232.
2013: Mike Recher; Michela Rizzini; Dale T Umetsu; Jolan E Walter; Hermann Eibel; Ari J Fried; Francesco Frugoni; Silvia Giliani; Christoph Hess; Hye Young Kim; Michel J Massaad; Divij Mathew; Luigi D Notarangelo; Raif S Geha
Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia.
Clinical immunology (Orlando, Fla.) 2013;146(2):84-9.
2013: Evelyne Khoriaty; Dale T Umetsu
Oral immunotherapy for food allergy: towards a new horizon.
Allergy, asthma & immunology research 2013;5(1):3-15.
2012: Rima Rachid; Dale T Umetsu
Immunological mechanisms for desensitization and tolerance in food allergy.
Seminars in immunopathology 2012;34(5):689-702.
2012: Dale T Umetsu
Early exposure to germs and the Hygiene Hypothesis.
Cell research 2012;22(8):1210-1.
2012: Mohanraj Manangeeswaran; Alessandro Perrella; Oreste Perrella; Cecilia Tami; Dale T Umetsu; Nadia Amharref; Jose M Casasnovas; Rosemarie H Dekruyff; Gordon J Freeman; Jérôme Jacques; Krishnamurthy Konduru; Gerardo G Kaplan
Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans.
Gastroenterology 2012;142(7):1516-25.e3.
2012: David I Kasahara; Hye Y Kim; Christopher Hug; Jordan Jastrab; Huiqing Si; Jennifer Tran; Dale T Umetsu; Norah G Verbout; Alison S Williams; Allison P Wurmbrand; Stephanie A Shore
Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(9):4558-67.
2012: D Bedoret; Rosemarie H Dekruyff; Robert G Hamilton; Elisabeth G Hoyte; K C Nadeau; L C Schneider; V Shaw; A K Singh; Dale T Umetsu
Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab.
Mucosal immunology 2012;5(3):267-76.
2012: Steven Z Josefowicz; Hye Young Kim; Rachel E Niec; piper meigs treuting; Dale T Umetsu; Ye Zheng; Takatoshi Chinen; Alexander Y Rudensky
Extrathymically generated regulatory T cells control mucosal TH2 inflammation.
Nature 2012;482(7385):395-9.
2012: Kari C Nadeau; Rosemarie H Dekruyff; Shuba Iyengar; Arunima Kohli; Dale T Umetsu
Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy.
Immunology and allergy clinics of North America 2012;32(1):111-33.
2011: Grace P Yu; David R Berk; Geneviève de Saint Basile; Elizabeth Dunn; Kristina Kavanau; Perrine Knapnougel; Nathalie Lambert; David B Lewis; Kari C Nadeau; Jennifer M Puck; Joseph Roberts; E Richard Stiehm; Dale T Umetsu; Morton J Cowan
Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID.
Pediatric transplantation 2011;15(7):733-41.
2011: Ya-Jen Chang; Rosemarie H Dekruyff; Hye Young Kim; Andrew N J McKenzie; Dirk E Smith; Lee A Albacker; Nicole Baumgarth; Dale T Umetsu
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.
Nature immunology 2011;12(7):631-8.
2011: Kari C Nadeau; Lynda C Schneider; Lisa Hoyte; Irene Borras; Dale T Umetsu
Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy.
The Journal of allergy and clinical immunology 2011;127(6):1622-4.
2011: Sheng Xiao; Bing Zhu; Hulin Jin; Chen Zhu; Dale T Umetsu; Rosemarie H Dekruyff; Vijay K Kuchroo
Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.
European journal of immunology 2011;41(6):1539-49.
2011: Hye Young Kim; María Belén Eyheramonho; Muriel Pichavant; Carlos Gonzalez Cambaceres; Ponpan Matangkasombut; Guillermo Cervio; Silvina Kuperman; Rita Moreiro; Krishnamurthy Konduru; Mohanraj Manangeeswaran; Gordon J Freeman; Gerardo G Kaplan; Rosemarie H Dekruyff; Dale T Umetsu; Sergio D Rosenzweig
A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans.
The Journal of clinical investigation 2011;121(3):1111-8.
2011: Ya-Jen Chang; Hye Young Kim; Lee A Albacker; Hyun Hee Lee; Nicole Baumgarth; Shizuo Akira; Paul B Savage; Shin Endo; Takashi Yamamura; Janneke Maaskant; Naoki Kitano; Abel Singh; Apoorva Bhatt; Gurdyal S Besra; Peter van den Elzen; Ben Appelmelk; Richard W Franck; Guangwu Chen; Rosemarie H Dekruyff; Michio Shimamura; Petr Illarionov; Dale T Umetsu
Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.
The Journal of clinical investigation 2011;121(1):57-69.
2010: S-L Catherine Jin; Sho Goya; Susumu Nakae; Dan Wang; Matthew Bruss; Chiaoyin Hou; Dale T Umetsu; Marco Conti
Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.
The Journal of allergy and clinical immunology 2010;126(6):1252-9.e12.
2010: Lee A Albacker; Piia Karisola; Ya-Jen Chang; Sarah E Umetsu; Meixia Zhou; Omid Akbari; Norimoto Kobayashi; Nicole Baumgarth; Gordon J Freeman; Dale T Umetsu; Rosemarie H Dekruyff
TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6839-49.
2010: Hyun-Hee Lee; Everett Meyer; Sho Goya; Muriel Pichavant; Hye Young Kim; Xia Bu; Sarah E Umetsu; Jennifer C Jones; Paul B Savage; Yoichiro Iwakura; Jose M Casasnovas; Gerardo Kaplan; Gordon J Freeman; Rosemarie H Dekruyff; Dale T Umetsu
Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(9):5225-35.
2010: Hye Young Kim; Rosemarie H Dekruyff; Dale T Umetsu
The many paths to asthma: phenotype shaped by innate and adaptive immunity.
Nature immunology 2010;11(7):577-84.
2010: Gordon J Freeman; José M Casasnovas; Dale T Umetsu; Rosemarie H Dekruyff
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.
Immunological reviews 2010;235(1):172-89.
2010: Raffi Tachdjian; Shadi Al Khatib; Andreas Schwinglshackl; Hong Sook Kim; Andrew Chen; Julie Blasioli; Clinton Mathias; Hye Young Kim; Dale T Umetsu; Hans C Oettgen; Talal A Chatila
In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.
The Journal of allergy and clinical immunology 2010;125(5):1128-1136.e8.
2010: Dale T Umetsu; Rosemarie H Dekruyff
Natural killer T cells are important in the pathogenesis of asthma: the many pathways to asthma.
The Journal of allergy and clinical immunology 2010;125(5):975-9.
2010: Lisa M Stutius; Itai Pessach; Joanne Lee; Mindy S Lo; Sharon Levy; Patricia Schram; Miriam Schizer; Jackson Wong; Wanda Phipatanakul; Dale T Umetsu
Sublingual desensitization for buprenorphine hypersensitivity.
The Journal of allergy and clinical immunology 2010;125(4):938-9.
2010: Dale T Umetsu; Rosemarie H Dekruyff
The regulatory role of natural killer T cells in the airways.
The international journal of biochemistry & cell biology 2010;42(4):529-34.
2010: Rosemarie H Dekruyff; Xia Bu; Angela Ballesteros; César Santiago; Yee-Ling E Chim; Hyun-Hee Lee; Piia Karisola; Muriel Pichavant; Gerardo G Kaplan; Dale T Umetsu; Gordon J Freeman; José M Casasnovas
T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1918-30.
2009: Rui He; Hye Young Kim; Juhan Yoon; Michiko K Oyoshi; Andrew MacGinnitie; Sho Goya; Eva-Jasmin Freyschmidt; Paul J Bryce; Andrew N J McKenzie; Dale T Umetsu; Hans C Oettgen; Raif S Geha
Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
The Journal of allergy and clinical immunology 2009;124(4):761-70.e1.
2009: Tangsheng Yi; Ying Chen; Lin Wang; Gong Du; Daniel Huang; Dongchang Zhao; Heather Johnston; James Young; Ivan Todorov; Dale T Umetsu; Lieping Chen; Yoichiro Iwakura; Fouad Kandeel; Stephen Forman; Defu Zeng
Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease.
Blood 2009;114(14):3101-12.
2009: P Matangkasombut; M Pichavant; Rosemarie H Dekruyff; Dale T Umetsu
Natural killer T cells and the regulation of asthma.
Mucosal immunology 2009;2(5):383-92.
2009: Onyinye I Iweala; Donald W Smith; Kabir S Matharu; Isabel Sada-Ovalle; Dana D Nguyen; Rosemarie H Dekruyff; Dale T Umetsu; Samuel M Behar; Cathryn R Nagler
Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2252-60.
2009: Yitang Li; Yonghui Jia; Muriel Pichavant; Fabien Loison; Bara Sarraj; Anongnard Kasorn; Jian You; Bryanne E Robson; Dale T Umetsu; Joseph P Mizgerd; Keqiang Ye; Hongbo R Luo
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia.
Blood 2009;113(20):4930-41.
2009: Muriel Pichavant; Ponpan Matangkasombut; Rosemarie H Dekruyff; Dale T Umetsu
Natural killer T cells regulate the development of asthma.
Expert review of clinical immunology 2009;5(3):251-60.
2009: Roselynn Rodriguez-Manzanet; Rosemarie DeKruyff; Vijay K Kuchroo; Dale T Umetsu
The costimulatory role of TIM molecules.
Immunological reviews 2009;229(1):259-70.
2009: Ponpan Matangkasombut; Gautham Marigowda; Aaron Ervine; Luaie Idris; Muriel Pichavant; Hye Young Kim; Takahiro Yasumi; S Brian Wilson; Rosemarie H Dekruyff; John L Faul; Elliot Israel; Omid Akbari; Dale T Umetsu
Natural killer T cells in the lungs of patients with asthma.
The Journal of allergy and clinical immunology 2009;123(5):1181-5.
2009: Hye Young Kim; Muriel Pichavant; Ponpan Matangkasombut; Youngil I Koh; Paul B Savage; Rosemarie H Dekruyff; Dale T Umetsu
The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):3252-61.
2009: Christophe Mariat; Nicolas Degauque; Savithri Balasubramanian; James Kenny; Rosemarie H Dekruyff; Dale T Umetsu; Vijay K Kuchroo; Xin Xiao Zheng; Terry B Strom
Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1379-85.
2009: Fabien Stenard; Christine Nguyen; Ken Cox; Neeraja Kambham; Dale T Umetsu; Sheri M Krams; Carlos O Esquivel; Olivia M Martinez
Decreases in circulating CD4+CD25hiFOXP3+ cells and increases in intragraft FOXP3+ cells accompany allograft rejection in pediatric liver allograft recipients.
Pediatric transplantation 2009;13(1):70-80.
2008: Youngil I Koh; Hye Young Kim; Everett H Meyer; Muriel Pichavant; Omid Akbari; Takahiro Yasumi; Paul B Savage; Rosemarie H Dekruyff; Dale T Umetsu
Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4560-9.
2008: Ponpan Matangkasombut; Muriel Pichavant; Takahiro Yasumi; Carrie Hendricks; Paul B Savage; Rosemarie H Dekruyff; Dale T Umetsu
Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primates.
The Journal of allergy and clinical immunology 2008;121(5):1287-9.
2008: Omid Akbari; Philippe Stock; Everett Meyer; Gordon J Freeman; Arlene H Sharpe; Dale T Umetsu; Rosemarie H Dekruyff
ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5448-56.
2008: Muriel Pichavant; Sho Goya; Everett Meyer; Richard A Johnston; Hye Y Kim; Ponpan Matangkasombut; Ming Zhu; Yoichiro Iwakura; Paul B Savage; Rosemarie H Dekruyff; Stephanie A Shore; Dale T Umetsu
Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17.
The Journal of experimental medicine 2008;205(2):385-93.
2008: Michiko K Oyoshi; Paul J Bryce; Sho Goya; Muriel Pichavant; Dale T Umetsu; Hans C Oettgen; Erdyni N Tsitsikov
TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1878-85.
2008: Nicolas Degauque; Christophe Mariat; James Kenny; Dong Zhang; Wenda Gao; Minh Diem Vu; Sophoclis Alexopoulos; Mohammed Oukka; Dale T Umetsu; Rosemarie H Dekruyff; Vijay K Kuchroo; Xin Xiao Zheng; Terry B Strom
Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.
The Journal of clinical investigation 2008;118(2):735-41.
2008: Everett Meyer; Rosemarie H Dekruyff; Dale T Umetsu
T cells and NKT cells in the pathogenesis of asthma.
Annual review of medicine 2008;59():281-92.
2008: Ponpan Matangkasombut; Muriel Pichavant; Doris E Saez; Silvia Giliani; Evelina Mazzolari; Andrea Finocchi; Anna Villa; Cristina Sobacchi; Patricia Cortes; Dale T Umetsu; Luigi D Notarangelo
Lack of iNKT cells in patients with combined immune deficiency due to hypomorphic RAG mutations.
Blood 2008;111(1):271-4.
2007: Norimoto Kobayashi; Piia Karisola; Victor Peña-Cruz; David M Dorfman; Masahisa Jinushi; Sarah E Umetsu; Manish J Butte; Haruo Nagumo; Irina Chernova; Baogong Zhu; Arlene H Sharpe; Susumu Ito; Glenn Dranoff; Gerardo G Kaplan; José M Casasnovas; Dale T Umetsu; Rosemarie H Dekruyff; Gordon J Freeman
TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
Immunity 2007;27(6):927-40.
2007: Muriel Pichavant; Sho Goya; Eckard Hamelmann; Erwin W Gelfand; Dale T Umetsu
Animal models of airway sensitization.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2007;Chapter 15():Unit 15.18.
2007: Everett Meyer; Marc-André Wurbel; Tracy L Staton; Muriel Pichavant; Matthew J Kan; Paul B Savage; Rosemarie H Dekruyff; Eugene C Butcher; James J Campbell; Dale T Umetsu
iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4661-71.
2007: Susumu Nakae; Motoyasu Iikura; Hajime Suto; Hisaya Akiba; Dale T Umetsu; Rosemarie H Dekruyff; Hirohisa Saito; Stephen J Galli
TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.
Blood 2007;110(7):2565-8.
2007: Omid Akbari; John L Faul; Dale T Umetsu
Invariant natural killer T cells in obstructive pulmonary diseases.
The New England journal of medicine 2007;357(2):193-4; author reply 194-5.
2007: Sheng Xiao; Nader Najafian; Jayagopala Reddy; Monica J Albin; Chen Zhu; Eric Jensen; Jaime Imitola; Thomas Korn; Ana C Anderson; Zheng Zhang; Cristina Gutierrez; Thomas Moll; Raymond A Sobel; Dale T Umetsu; Hideo Yagita; Hisaya Akiba; Terry Strom; Mohamed H Sayegh; Rosemarie H Dekruyff; Samia J Khoury; Vijay K Kuchroo
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
The Journal of experimental medicine 2007;204(7):1691-702.
2007: Cecilia Tami; Erica Silberstein; Mohanraj Manangeeswaran; Gordon J Freeman; Sarah E Umetsu; Rosemarie H Dekruyff; Dale T Umetsu; Gerardo G Kaplan
Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions.
Journal of virology 2007;81(7):3437-46.
2007: Everett Meyer; Rosemarie H Dekruyff; Dale T Umetsu
iNKT cells in allergic disease.
Current topics in microbiology and immunology 2007;314():269-91.
2007: Dale T Umetsu; Everett Meyer; Rosemarie H Dekruyff
Natural killer T cells regulate the development of asthma.
International reviews of immunology 2007;26(1-2):121-40.
2006: Abdallah Elkhal; Muriel Pichavant; Rui He; Jordan Scott; Everett Meyer; Sho Goya; Raif S Geha; Dale T Umetsu
CD1d restricted natural killer T cells are not required for allergic skin inflammation.
The Journal of allergy and clinical immunology 2006;118(6):1363-8.
2006: Dale T Umetsu; Rosemarie H Dekruyff
A role for natural killer T cells in asthma.
Nature reviews. Immunology 2006;6(12):953-8.
2006: Dale T Umetsu; Rosemarie H Dekruyff
Immune dysregulation in asthma.
Current opinion in immunology 2006;18(6):727-32.
2006: Dale T Umetsu; Rosemarie H Dekruyff
The regulation of allergy and asthma.
Immunological reviews 2006;212():238-55.
2006: Claudia Macaubas; Jan L Wahlstrom; Ana Paula Galvão Da Silva; Thomas G Forsthuber; Grete Sønderstrup; William W Kwok; Rosemarie H Dekruyff; Dale T Umetsu
Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):5069-77.
2006: Omid Akbari; John L Faul; Elisabeth G Hoyte; Gerald J Berry; Jan Wahlström; Mitchell Kronenberg; Rosemarie H Dekruyff; Dale T Umetsu
CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma.
The New England journal of medicine 2006;354(11):1117-29.
2006: Everett Meyer; Sho Goya; Omid Akbari; Gerald J Berry; Paul B Savage; Mitchell Kronenberg; Toshinori Nakayama; Rosemarie H Dekruyff; Dale T Umetsu
Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2782-7.
2006: Philippe Stock; Rosemarie H Dekruyff; Dale T Umetsu
Inhibition of the allergic response by regulatory T cells.
Current opinion in allergy and clinical immunology 2006;6(1):12-6.
2006: Dale T Umetsu
Understanding the immunological basis of asthma; immunotherapy and regulatory T cells.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 2006;(95):211-4; discussion 215-6.
2006: Vijay K Kuchroo; Jennifer Hartt Meyers; Dale T Umetsu; Rosemarie H Dekruyff
TIM family of genes in immunity and tolerance.
Advances in immunology 2006;91():227-49.
2005: Philippe Stock; Omid Akbari; Rosemarie H Dekruyff; Dale T Umetsu
Respiratory tolerance is inhibited by the administration of corticosteroids.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7380-7.
2005: Jennifer Hartt Meyers; Sumone Chakravarti; David Schlesinger; Zsolt Illes; Hanspeter Waldner; Sarah E Umetsu; James Kenny; Xin Xiao Zheng; Dale T Umetsu; Rosemarie H Dekruyff; Terry B Strom; Vijay K Kuchroo
TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.
Nature immunology 2005;6(5):455-64.
2005: Sarah E Umetsu; Wan-Ling Lee; Jennifer J McIntire; Laura Downey; Bharati Sanjanwala; Omid Akbari; Gerald J Berry; Haruo Nagumo; Gordon J Freeman; Dale T Umetsu; Rosemarie H Dekruyff
TIM-1 induces T cell activation and inhibits the development of peripheral tolerance.
Nature immunology 2005;6(5):447-54.
2005: Dale T Umetsu; Jennifer J McIntire; Rosemarie H Dekruyff
TIM-1, hepatitis A virus and the hygiene theory of atopy: association of TIM-1 with atopy.
Journal of pediatric gastroenterology and nutrition 2005;40 Suppl 1():S43.
2005: Dale T Umetsu
Revising the immunological theories of asthma and allergy.
Lancet 2005;365(9454):98-100.
2005: Omid Akbari; Dale T Umetsu
Role of regulatory dendritic cells in allergy and asthma.
Current allergy and asthma reports 2005;5(1):56-61.
2004: Dale T Umetsu; Rosemarie H Dekruyff
Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment.
Annals of the New York Academy of Sciences 2004;1029():88-93.
2004: Omid Akbari; Dale T Umetsu
Role of regulatory dendritic cells in allergy and asthma.
Current opinion in allergy and clinical immunology 2004;4(6):533-8.
2004: Philippe Stock; Omid Akbari; Gerald Berry; Gordon J Freeman; Rosemarie H Dekruyff; Dale T Umetsu
Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity.
Nature immunology 2004;5(11):1149-56.
2004: Philippe Stock; Tilmann Kallinich; Omid Akbari; David Quarcoo; Kerstin Gerhold; Ulrich Wahn; Dale T Umetsu; Eckard Hamelmann
CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation.
European journal of immunology 2004;34(7):1817-27.
2004: Richard S Shames; Paul J Sharek; Michelle Mayer; Thomas N Robinson; Elisabeth G Hoyte; Frances Gonzalez-Hensley; David A Bergman; Dale T Umetsu
Effectiveness of a multicomponent self-management program in at-risk, school-aged children with asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2004;92(6):611-8.
2004: Dale T Umetsu
Flu strikes the hygiene hypothesis.
Nature medicine 2004;10(3):232-4.
2004: Jennifer J McIntire; Dale T Umetsu; Rosemarie H Dekruyff
TIM-1, a novel allergy and asthma susceptibility gene.
Springer seminars in immunopathology 2004;25(3-4):335-48.
2004: Dale T Umetsu; Rosemarie H Dekruyff
Editorial overview: novel concepts in the pathogenesis and therapy of allergy and asthma.
Springer seminars in immunopathology 2004;25(3-4):231-6.
2004: Elizabeth C TePas; Elisabeth G Hoyte; Jennifer J McIntire; Dale T Umetsu
Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individuals.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2004;92(1):25-31.
2003: Omid Akbari; Philippe Stock; Rosemarie H Dekruyff; Dale T Umetsu
Role of regulatory T cells in allergy and asthma.
Current opinion in immunology 2003;15(6):627-33.
2003: Marketa Hecht; Ling Lin; Clete A Kushida; Dale T Umetsu; Shahrad Taheri; Mali Einen; Emmanuel Mignot
Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy.
Sleep 2003;26(7):809-10.
2003: Jennifer J McIntire; Sarah E Umetsu; Claudia Macaubas; Elisabeth G Hoyte; Cengiz Cinnioglu; L Luca Cavalli-Sforza; Gregory S Barsh; Joachim Hallmayer; Peter A Underhill; Neil J Risch; Gordon J Freeman; Rosemarie H Dekruyff; Dale T Umetsu
Immunology: hepatitis A virus link to atopic disease.
Nature 2003;425(6958):576.
2003: Céline Méhats; S-L Catherine Jin; Jan L Wahlstrom; Evelyn Law; Dale T Umetsu; Marco Conti
PDE4D plays a critical role in the control of airway smooth muscle contraction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1831-41.
2003: Dale T Umetsu; Omid Akbari; Rosemarie H Dekruyff
Regulatory T cells control the development of allergic disease and asthma.
The Journal of allergy and clinical immunology 2003;112(3):480-7; quiz 488.
2003: Claudia Macaubas; Rosemarie H Dekruyff; Dale T Umetsu
Respiratory tolerance in the protection against asthma.
Current drug targets. Inflammation and allergy 2003;2(2):175-86.
2003: Vijay K Kuchroo; Dale T Umetsu; Rosemarie H Dekruyff; Gordon J Freeman
The TIM gene family: emerging roles in immunity and disease.
Nature reviews. Immunology 2003;3(6):454-62.
2003: Omid Akbari; Philippe Stock; Everett Meyer; Mitchell Kronenberg; Stephane Sidobre; Toshinori Nakayama; Masaru Taniguchi; Michael J Grusby; Rosemarie H Dekruyff; Dale T Umetsu
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.
Nature medicine 2003;9(5):582-8.
2003: Omid Akbari; Philippe Stock; Rosemarie H Dekruyff; Dale T Umetsu
Mucosal tolerance and immunity: regulating the development of allergic disease and asthma.
International archives of allergy and immunology 2003;130(2):108-18.
2002: Paul J Sharek; Michelle L Mayer; Lisa Loewy; Thomas N Robinson; Richard S Shames; Dale T Umetsu; David A Bergman
Agreement among measures of asthma status: a prospective study of low-income children with moderate to severe asthma.
Pediatrics 2002;110(4):797-804.
2002: Jae-Won Oh; Christine M Seroogy; Everett Meyer; Omid Akbari; Gerald Berry; C Garrison Fathman; Rosemarie H Dekruyff; Dale T Umetsu
CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation.
The Journal of allergy and clinical immunology 2002;110(3):460-8.
2002: Omid Akbari; Gordon J Freeman; Everett Meyer; Edward Greenfield; Tammy T Chang; Arlene H Sharpe; Gerald Berry; Rosemarie H Dekruyff; Dale T Umetsu
Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity.
Nature medicine 2002;8(9):1024-32.
2002: Dale T Umetsu; Jennifer J McIntire; Omid Akbari; Claudia Macaubas; Rosemarie H Dekruyff
Asthma: an epidemic of dysregulated immunity.
Nature immunology 2002;3(8):715-20.
2002: Daphne C Tsitoura; V Pete Yeung; Rosemarie H Dekruyff; Dale T Umetsu
Critical role of B cells in the development of T cell tolerance to aeroallergens.
International immunology 2002;14(6):659-67.
2002: Jun Deng; Rosemarie H Dekruyff; Gordon J Freeman; Dale T Umetsu; Shoshana Levy
Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses.
International immunology 2002;14(5):513-23.
2001: Jennifer J McIntire; Sarah E Umetsu; Omid Akbari; M Potter; Vijay K Kuchroo; Gregory S Barsh; Gordon J Freeman; Dale T Umetsu; Rosemarie H Dekruyff
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
Nature immunology 2001;2(12):1109-16.
2001: DM Walter; Jennifer J McIntire; Gerald Berry; Andrew N J McKenzie; Debra D Donaldson; Rosemarie H Dekruyff; Dale T Umetsu
Critical role for IL-13 in the development of allergen-induced airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4668-75.
2001: Omid Akbari; Rosemarie H Dekruyff; Dale T Umetsu
Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen.
Nature immunology 2001;2(8):725-31.
2001: DM Walter; C P Wong; Rosemarie H Dekruyff; G J Berry; Shoshana Levy; Dale T Umetsu
Il-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6392-8.
2001: R L Blumenthal; D E Campbell; P Hwang; Rosemarie H Dekruyff; Lorry R Frankel; Dale T Umetsu
Human alveolar macrophages induce functional inactivation in antigen-specific CD4 T cells.
The Journal of allergy and clinical immunology 2001;107(2):258-64.
2001: H T Maecker; G Hansen; DM Walter; Rosemarie H Dekruyff; Shoshana Levy; Dale T Umetsu
Vaccination with allergen-IL-18 fusion DNA protects against, and reverses established, airway hyperreactivity in a murine asthma model.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):959-65.
2000: D Campbell; R H DeKruyff; Dale T Umetsu
Allergen immunotherapy: novel approaches in the management of allergic diseases and asthma.
Clinical immunology (Orlando, Fla.) 2000;97(3):193-202.
2000: J Deng; V P Yeung; Daphne C Tsitoura; Rosemarie H Dekruyff; Dale T Umetsu; Shoshana Levy
Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5054-61.
2000: Daphne C Tsitoura; S Kim; Karim Dabbagh; Gerald Berry; David B Lewis; Dale T Umetsu
Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3484-91.
2000: Daphne C Tsitoura; R L Blumenthal; Gerald Berry; Rosemarie H Dekruyff; Dale T Umetsu
Mechanisms preventing allergen-induced airways hyperreactivity: role of tolerance and immune deviation.
The Journal of allergy and clinical immunology 2000;106(2):239-46.
2000: G Hansen; S Jin; Dale T Umetsu; Marco Conti
Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6751-6.
2000: GJ Thorbecke; Dale T Umetsu; Rosemarie H Dekruyff; G Hansen; LZ Chen; GM Hochwald
When engineered to produce latent TGF-beta1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes.
Cytokine & growth factor reviews 2000;11(1-2):89-96.
2000: G Hansen; Jennifer J McIntire; V P Yeung; Gerald Berry; GJ Thorbecke; L Chen; Rosemarie H Dekruyff; Dale T Umetsu
CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation.
The Journal of clinical investigation 2000;105(1):61-70.
2000: G Hansen; V Pete Yeung; Gerald Berry; Dale T Umetsu; Rosemarie H Dekruyff
Vaccination with heat-killed Listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: role of CD8+ T cells and IL-18.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):223-30.
1999: P Maguire; C Nicodemus; D Robinson; D Aaronson; Dale T Umetsu
The safety and efficacy of ALLERVAX CAT in cat allergic patients.
Clinical immunology (Orlando, Fla.) 1999;93(3):222-31.
1999: Dale T Umetsu; Rosemarie H Dekruyff
Interleukin-10: The missing link in asthma regulation?
American journal of respiratory cell and molecular biology 1999;21(5):562-3.
1999: Daphne C Tsitoura; Rosemarie H Dekruyff; Jonathan R Lamb; Dale T Umetsu
Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2592-600.
1999: S Benjaponpitak; Anthony E Oro; P Maguire; V Marinkovich; Rosemarie H Dekruyff; Dale T Umetsu
The kinetics of change in cytokine production by CD4 T cells during conventional allergen immunotherapy.
The Journal of allergy and clinical immunology 1999;103(3 Pt 1):468-75.
1999: G Hansen; Gerald Berry; Rosemarie H Dekruyff; Dale T Umetsu
Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation.
The Journal of clinical investigation 1999;103(2):175-83.
1998: V Pete Yeung; RS Gieni; Dale T Umetsu; Rosemarie H Dekruyff
Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4146-52.
1998: L Tang; S Benjaponpitak; Rosemarie H Dekruyff; Dale T Umetsu
Reduced prevalence of allergic disease in patients with multiple sclerosis is associated with enhanced IL-12 production.
The Journal of allergy and clinical immunology 1998;102(3):428-35.
1998: Rosemarie H Dekruyff; Y Fang; Dale T Umetsu
Corticosteroids enhance the capacity of macrophages to induce Th2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2231-7.
1998: A E Macaulay; Rosemarie H Dekruyff; Dale T Umetsu
Antigen-primed T cells from B cell-deficient JHD mice fail to provide B cell help.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1694-700.
1998: Luiz Vicente Rizzo; Elizabeth Secord; Vincent K Tsiagbe; Dale T Umetsu; Rosemarie H Dekruyff; William J Simmons; GJ Thorbecke
Components essential for the generation of germinal centers.
Developmental immunology 1998;6(3-4):325-30.
1997: Dale T Umetsu; Rosemarie H Dekruyff
TH1 and TH2 CD4+ cells in human allergic diseases.
The Journal of allergy and clinical immunology 1997;100(1):1-6.
1997: M H Blotta; Rosemarie H Dekruyff; Dale T Umetsu
Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5589-95.
1997: A E Macaulay; Rosemarie H Dekruyff; Christopher C Goodnow; Dale T Umetsu
Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4171-9.
1997: T S Kim; Rosemarie H Dekruyff; R Rupper; Holden T Maecker; Shoshana Levy; Dale T Umetsu
An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4137-44.
1997: Irina M Conboy; Rosemarie H Dekruyff; KM Tate; ZA Cao; Thomas A Moore; Dale T Umetsu; Patricia P Jones
Novel genetic regulation of T helper 1 (Th1)/Th2 cytokine production and encephalitogenicity in inbred mouse strains.
The Journal of experimental medicine 1997;185(3):439-51.
1997: RS Gieni; Dale T Umetsu; Rosemarie H Dekruyff
Ly1- (CD5-) B cells produce interleukin (IL)-10.
Cellular immunology 1997;175(2):164-70.
1997: Rosemarie H Dekruyff; RS Gieni; Dale T Umetsu
Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):359-66.
1996: Elizabeth Secord; Luiz Vicente Rizzo; E W Barroso; Dale T Umetsu; GJ Thorbecke; Rosemarie H Dekruyff
Reconstitution of germinal center formation in nude mice with Th1 and Th2 clones.
Cellular immunology 1996;174(2):173-9.
1996: R S Gieni; Y Fang; Trinchieri Giorgio; Dale T Umetsu; Rosemarie H Dekruyff
Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes.
International immunology 1996;8(10):1511-20.
1996: H Secrist; S Levy; Rosemarie H Dekruyff; Dale T Umetsu
Ligation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4+ T cells.
European journal of immunology 1996;26(7):1435-42.
1996: A S Oro; T J Guarino; R Driver; Lawrence Steinman; Dale T Umetsu
Regulation of disease susceptibility: decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis.
The Journal of allergy and clinical immunology 1996;97(6):1402-8.
1996: M H Blotta; Jason Marshall; Rosemarie H Dekruyff; Dale T Umetsu
Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3133-40.
1995: Jason Marshall; H Secrist; Rosemarie H Dekruyff; Stanley Wolf; Dale T Umetsu
IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):111-7.
1995: Rosemarie H Dekruyff; Y Fang; Stanley Wolf; Dale T Umetsu
IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T cells through an effect on antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2578-87.
1995: H Secrist; Rosemarie H Dekruyff; Dale T Umetsu
Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type.
The Journal of experimental medicine 1995;181(3):1081-9.
1995: Luiz Vicente Rizzo; Rosemarie H Dekruyff; Dale T Umetsu; Rachel R Caspi
Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo.
European journal of immunology 1995;25(3):708-16.
1995: Rosemarie H Dekruyff; Y Fang; H Secrist; Dale T Umetsu
IL-4 synthesis by in vivo-primed memory CD4+ T cells: II. Presence of IL-4 is not required for IL-4 synthesis in primed CD4+ T cells.
Journal of clinical immunology 1995;15(2):105-15.
1995: C J Chelen; Y Fang; G J Freeman; H Secrist; Jason Marshall; P T Hwang; L R Frankel; Rosemarie H Dekruyff; Dale T Umetsu
Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules.
The Journal of clinical investigation 1995;95(3):1415-21.
1995: Rosemarie H Dekruyff; Y Fang; Dale T Umetsu
IL-4-based helper activity of CD4+ T cells is radiation sensitive.
Cellular immunology 1995;160(2):248-56.
1994: Francisco X Arredondo-Vega; Ines Santisteban; S Kelly; C M Schlossman; Dale T Umetsu; Michael S Hershfield
Correct splicing despite mutation of the invariant first nucleotide of a 5' splice site: a possible basis for disparate clinical phenotypes in siblings with adenosine deaminase deficiency.
American journal of human genetics 1994;54(5):820-30.
1994: Dale T Umetsu; C M Schlossman; H D Ochs; Michael S Hershfield
Heterogeneity of phenotype in two siblings with adenosine deaminase deficiency.
The Journal of allergy and clinical immunology 1994;93(2):543-50.
1993: Rosemarie H Dekruyff; Luiz Vicente Rizzo; Dale T Umetsu
Induction of immunoglobulin synthesis by CD4+ T cell clones.
Seminars in immunology 1993;5(6):421-30.
1993: H Secrist; C J Chelen; Y Wen; Jason Marshall; Dale T Umetsu
Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.
The Journal of experimental medicine 1993;178(6):2123-30.
1993: Jason Marshall; Y Wen; J S Abrams; Dale T Umetsu
In vitro synthesis of IL-4 by human CD4+ T cells requires repeated antigenic stimulation.
Cellular immunology 1993;152(1):18-34.
1992: Rosemarie H Dekruyff; Y Fang; Dale T Umetsu
IL-4 synthesis by in vivo primed keyhole limpet hemocyanin-specific CD4+ T cells. I. Influence of antigen concentration and antigen-presenting cell type.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(11):3468-76.
1992: Luiz Vicente Rizzo; Rosemarie H Dekruyff; Dale T Umetsu
Generation of B cell memory and affinity maturation. Induction with Th1 and Th2 T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):3733-9.
1991: Luiz Vicente Rizzo; Dale T Umetsu; Rosemarie H Dekruyff
Differential regulation of antigen presentation in high- and low-IgE responder mice.
European journal of immunology 1991;21(7):1767-70.
1991: Andrew D Zelenetz; M J Campbell; D W Bahler; S Takahashi; R Oren; L Esserman; Dale T Umetsu; L W Kwak; D G Maloney; S Brown
Follicular lymphoma: a model of lymphoid tumor progression in man.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1991;2 Suppl 2():115-22.
1990: Rosemarie H Dekruyff; R R Mosmann; Dale T Umetsu
Induction of antibody synthesis by CD4+ T cells: IL 5 is essential for induction of antigen-specific antibody responses by TH2 but not TH1 clones.
European journal of immunology 1990;20(10):2219-27.
1990: Dale T Umetsu; L Esserman; T A Donlon; Rosemarie H Dekruyff; Ronald Levy
Induction of proliferation of human follicular (B type) lymphoma cells by cognate interaction with CD4+ T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2550-7.
1989: Rosemarie H Dekruyff; T Turner; J S Abrams; M A Palladino; Dale T Umetsu
Induction of human IgE synthesis by CD4+ T cell clones. Requirement for interleukin 4 and low molecular weight B cell growth factor.
The Journal of experimental medicine 1989;170(5):1477-93.
1989: Rosemarie H Dekruyff; S T Ju; A J Hunt; T R Mosmann; Dale T Umetsu
Induction of antigen-specific antibody responses in primed and unprimed B cells. Functional heterogeneity among Th1 and Th2 T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2575-82.