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Jashvant Unadkat

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Macaca nemestrina

Physiology

Chemicals & Drugs

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Publications

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Alice Ban Ke; Srikanth C Nallani; Amin Rostami-Hodjegan; Nina Isoherranen; Ping Zhao; Jashvant D Unadkat
A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.
Li Liu; Jashvant D Unadkat
Interaction between HIV protease inhibitors (PIs) and hepatic transporters in sandwich cultured human hepatocytes: implication for PI-based DDIs.
Alice Ban Ke; Jeanne M Link; David A Mankoff; Mark Muzi; Francisco S Chung; Sara Eyal; Jashvant D Unadkat
Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition.

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All Publications

2013: Alice Ban Ke; Srikanth C Nallani; Amin Rostami-Hodjegan; Nina Isoherranen; Ping Zhao; Jashvant D Unadkat
A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(4):801-13.
2013: Li Liu; Jashvant D Unadkat
Interaction between HIV protease inhibitors (PIs) and hepatic transporters in sandwich cultured human hepatocytes: implication for PI-based DDIs.
Biopharmaceutics & drug disposition 2013;34(3):155-64.
2013: Alice Ban Ke; Jeanne M Link; David A Mankoff; Mark Muzi; Francisco S Chung; Sara Eyal; Jashvant D Unadkat
Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013;54(3):437-46.
2013: Bhagwat Prasad; Yurong Lai; Yvonne Lin; Jashvant D Unadkat
Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype.
Journal of pharmaceutical sciences 2013;102(3):787-93.
2013: Ioannis Papageorgiou; Susan Grepper; Jashvant D Unadkat
Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(2):281-90.
2013: Kazuya Ishida; Hiroyoshi Matsukura; Toshio Miyawaki; Masato Taguchi; Osamu Uemura; Jashvant D Unadkat; Hitomi Watanabe; Zufei Zhang; Miki Fukao; Yukiya Hashimoto
Effect of salt intake on bioavailability of mizoribine in healthy Japanese males.
Drug metabolism and pharmacokinetics 2013;28(1):75-80.
2012: Aaron M Moss; Ana Ruiz-Garcia; Doo-Sup Choi; Christopher J Endres; Jashvant D Unadkat
Role of the equilibrative and concentrative nucleoside transporters in the intestinal absorption of the nucleoside drug, ribavirin, in wild-type and Ent1(-/-) mice.
Molecular pharmaceutics 2012;9(9):2442-9.
2012: Li Liu; Ganesh M Mugundu; Divya Samineni; Pankaj B Desai; Brian J Kirby; Jashvant D Unadkat
Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR.
Biopharmaceutics & drug disposition 2012;33(4):207-17.
2012: Anand K Deo; Yurong Lai; Bhagwat Prasad; Larissa Balogh; Jashvant D Unadkat
Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(5):852-5.
2012: Peng Hsiao; Jashvant D Unadkat
P-glycoprotein-based loperamide-cyclosporine drug interaction at the rat blood-brain barrier: prediction from in vitro studies and extrapolation to humans.
Molecular pharmaceutics 2012;9(3):629-33.
2012: Brian J Kirby; Kenneth E Thummel; Ann C Collier; Evan D Kharasch; Dale Whittington; Jashvant D Unadkat
Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(3):610-6.
2011: Brian J Kirby; Kenneth E Thummel; Dale Whittington; Ann C Collier; Pankaj Desai; Vaishali Dixit; Evan D Kharasch; Jashvant D Unadkat
Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2329-37.
2011: Joseph K Zolnerciks; Catherine L Booth-Genthe; Anshul Gupta; Jennifer Harris; Jashvant D Unadkat
Substrate- and species-dependent inhibition of P-glycoprotein-mediated transport: implications for predicting in vivo drug interactions.
Journal of pharmaceutical sciences 2011;100(8):3055-61.
2011: Brian J Kirby; Ann C Collier; Evan D Kharasch; Dale Whittington; Kenneth E Thummel; Jashvant D Unadkat
Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(6):1070-8.
2010: Brian J Kirby; Jashvant D Unadkat
Impact of ignoring extraction ratio when predicting drug-drug interactions, fraction metabolized, and intestinal first-pass contribution.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(11):1926-33.
2010: Lindsey A Burnett; Edik M Blais; Jashvant D Unadkat; Bertil Hille; Stephen L Tilley; Donner F Babcock
Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm.
The Journal of biological chemistry 2010;285(44):33662-70.
2010: Nayoung Kang; Ah Hyun Jun; Yangzom Doma Bhutia; Natarajan Kannan; Jashvant D Unadkat; Rajgopal Govindarajan
Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorder mutations impair nucleoside transport, protein localization, and stability.
The Journal of biological chemistry 2010;285(36):28343-52.
2010: David A Plotnik; Lindsay E Emerick; Kenneth A Krohn; Jashvant D Unadkat; Jeffrey L Schwartz
Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(9):1464-71.
2010: Lin Zhou; Yi Zhang; Mary F Hebert; Jashvant D Unadkat; Qingcheng Mao
Increased glyburide clearance in the pregnant mouse model.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(9):1403-6.
2010: Lin Zhou; Suresh B Naraharisetti; Li Liu; Honggang Wang; Yvonne S Lin; Nina Isoherranen; Jashvant D Unadkat; Mary F Hebert; Qingcheng Mao
Contributions of human cytochrome P450 enzymes to glyburide metabolism.
Biopharmaceutics & drug disposition 2010;31(4):228-42.
2010: F S Chung; S Eyal; Mark Muzi; J M Link; David A Mankoff; Amal Kaddoumi; F O'Sullivan; P Hsiao; Jashvant D Unadkat
Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate.
British journal of pharmacology 2010;159(2):394-404.
2009: Christopher J Endres; Michael G Endres; Jashvant D Unadkat
Interplay of drug metabolism and transport: a real phenomenon or an artifact of the site of measurement?
Molecular pharmaceutics 2009;6(6):1756-65.
2009: Yi Zhang; Lin Zhou; Jashvant D Unadkat; Qingcheng Mao
Effect of pregnancy on nitrofurantoin disposition in mice.
Journal of pharmaceutical sciences 2009;98(11):4306-15.
2009: Christopher J Endres; Aaron M Moss; Rajgopal Govindarajan; Doo-Sup Choi; Jashvant D Unadkat
The role of nucleoside transporters in the erythrocyte disposition and oral absorption of ribavirin in the wild-type and equilibrative nucleoside transporter 1-/- mice.
The Journal of pharmacology and experimental therapeutics 2009;331(1):287-96.
2009: Mark Muzi; David A Mankoff; Jeanne M Link; Steve Shoner; Ann C Collier; Lucy Sasongko; Jashvant D Unadkat
Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(8):1267-75.
2009: Huixia Zhang; Xiaohui Wu; Suresh B Naraharisetti; Francisco Chung; Dale Whittington; Ahmad Mirfazaelian; Jashvant D Unadkat
Pregnancy does not increase CYP3A or P-glycoprotein activity in the non-human primate, Macaca nemestrina.
The Journal of pharmacology and experimental therapeutics 2009;330(2):586-95.
2009: Sara Eyal; Peng Hsiao; Jashvant D Unadkat
Drug interactions at the blood-brain barrier: fact or fantasy?
Pharmacology & therapeutics 2009;123(1):80-104.
2009: Huixia Zhang; Xiaohui Wu; Francisco Chung; Suresh B Naraharisetti; Dale Whittington; Ahmad Mirfazaelian; Jashvant D Unadkat
As in humans, pregnancy increases the clearance of the protease inhibitor nelfinavir in the nonhuman primate Macaca nemestrina.
The Journal of pharmacology and experimental therapeutics 2009;329(3):1016-22.
2009: Sara Eyal; Francisco S Chung; Mark Muzi; Jeanne M Link; David A Mankoff; Amal Kaddoumi; Finbarr O'Sullivan; Mary F Hebert; Jashvant D Unadkat
Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(5):798-806.
2009: Rajgopal Govindarajan; George P H Leung; Mingyan Zhou; Chung-Ming Tse; Joanne Wang; Jashvant D Unadkat
Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(4):G910-22.
2009: Christopher J Endres; Aaron M Moss; Ban Ke; Rajgopal Govindarajan; Doo-Sup Choi; Robert O Messing; Jashvant D Unadkat
The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes.
The Journal of pharmacology and experimental therapeutics 2009;329(1):387-98.
2008: Andrei M Mikheev; Tomo NABEKURA; Amal Kaddoumi; Theo K Bammler; Rajgopal Govindarajan; Mary F Hebert; Jashvant D Unadkat
Profiling gene expression in human placentae of different gestational ages: an OPRU Network and UW SCOR Study.
Reproductive sciences (Thousand Oaks, Calif.) 2008;15(9):866-77.
2008: Jashvant D Unadkat; Francisco Chung; Lucy Sasongko; Dale Whittington; Sara Eyal; David A Mankoff; Ann C Collier; Mark Muzi; Jeanne Link
Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites, in human and macaque plasma.
Nuclear medicine and biology 2008;35(8):911-7.
2008: Rajgopal Govindarajan; Christopher J Endres; Dale Whittington; Edward LeCluyse; Marçal Pastor-Anglada; Chung-Ming Tse; Jashvant D Unadkat
Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(3):G570-80.
2008: Huixia Zhang; Xiaohui Wu; Honggang Wang; Andrei M Mikheev; Qingcheng Mao; Jashvant D Unadkat
Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course.
Molecular pharmacology 2008;74(3):714-23.
2008: Stephan A Veltkamp; Dick Pluim; Monique van Eijndhoven; Maria J Bolijn; Felix H G Ong; Rajgopal Govindarajan; Jashvant D Unadkat; Jos H Beijnen; Jan H M Schellens
New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine.
Molecular cancer therapeutics 2008;7(8):2415-25.
2008: Brian J Kirby; Thomas F Kalhorn; Mary Hebert; Tom Easterling; Jashvant D Unadkat
Sensitive and specific LC-MS assay for quantification of digoxin in human plasma and urine.
Biomedical chromatography : BMC 2008;22(7):712-8.
2008: Anshul Gupta; Ganesh M Mugundu; Pankaj B Desai; Kenneth E Thummel; Jashvant D Unadkat
Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1172-80.
2008: Leslie J Dickmann; Suzanne Tay; Tauri D Senn; Huixia Zhang; Anthony Visone; Jashvant D Unadkat; Mary F Hebert; Nina Isoherranen
Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy.
Biochemical pharmacology 2008;75(8):1677-87.
2008: Lin Zhou; Suresh B Naraharisetti; Honggang Wang; Jashvant D Unadkat; Mary F Hebert; Qingcheng Mao
The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study.
Molecular pharmacology 2008;73(3):949-59.
2008: Peng Hsiao; Tot Bui; Rodney J Y Ho; Jashvant D Unadkat
In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(3):481-4.
2008: Honggang Wang; Eun-Woo Lee; Lin Zhou; Peter C K Leung; Douglas Ross; Jashvant D Unadkat; Qingcheng Mao
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells.
Molecular pharmacology 2008;73(3):845-54.
2008: Honggang Wang; Jashvant D Unadkat; Qingcheng Mao
Hormonal regulation of BCRP expression in human placental BeWo cells.
Pharmaceutical research 2008;25(2):444-52.
2007: Suresh B Naraharisetti; Brian J Kirby; Mary F Hebert; Thomas R Easterling; Jashvant D Unadkat
Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-transhydroxy glyburide in plasma and urine: an OPRU Network study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;860(1):34-41.
2007: Yi Zhang; Honggang Wang; Jashvant D Unadkat; Qingcheng Mao
Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(12):2154-8.
2007: Anshul Gupta; Jashvant D Unadkat; Qingcheng Mao
Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP).
Journal of pharmaceutical sciences 2007;96(12):3226-35.
2007: Rajgopal Govindarajan; Aimee H Bakken; Kelly Hudkins; Yurong Lai; F Javier Casado; Marçal Pastor-Anglada; Chung-Ming Tse; Jun Hayashi; Jashvant D Unadkat
In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(5):R1809-22.
2007: Vaishali Dixit; Niresh Hariparsad; Fang Li; Pankaj Desai; Kenneth E Thummel; Jashvant D Unadkat
Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1853-9.
2007: Amal Kaddoumi; Sung-Up Choi; Loren Kinman; Dale Whittington; Che-Chung Tsai; Rodney J Y Ho; Bradley D Anderson; Jashvant D Unadkat
Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(9):1459-62.
2007: Vaishali Dixit; Niresh Hariparsad; Pankaj Desai; Jashvant D Unadkat
In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities.
Biopharmaceutics & drug disposition 2007;28(5):257-62.
2007: B J Kirby; Jashvant D Unadkat
Grapefruit juice, a glass full of drug interactions?
Clinical pharmacology and therapeutics 2007;81(5):631-3.
2007: Jashvant D Unadkat; Diane Wara; Michael D Hughes; Anita A Mathias; Diane T Holland; Mary E Paul; James Connor; Sharon Huang; Bach-Yen Nguyen; D Heather Watts; Lynne M Mofenson; Elizabeth Smith; Paul Deutsch; Kathleen A Kaiser; Ruth E Tuomala
Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women.
Antimicrobial agents and chemotherapy 2007;51(2):783-6.
2006: Honggang Wang; Xiaohui Wu; Kelly Hudkins; Andrei Mikheev; Huixia Zhang; Anshul Gupta; Jashvant D Unadkat; Qingcheng Mao
Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors.
American journal of physiology. Endocrinology and metabolism 2006;291(6):E1295-304.
2006: Brian Kirby; Evan D Kharasch; Kenneth T Thummel; Vishal S Narang; Christine Hoffer; Jashvant D Unadkat
Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities.
Journal of clinical pharmacology 2006;46(11):1313-9.
2006: Anshul Gupta; Yang Dai; R Robert Vethanayagam; Mary F Hebert; Kenneth E Thummel; Jashvant D Unadkat; Douglas Ross; Qingcheng Mao
Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan.
Cancer chemotherapy and pharmacology 2006;58(3):374-83.
2006: Eun-Woo Lee; Yurong Lai; Huixia Zhang; Jashvant D Unadkat
Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine.
The Journal of biological chemistry 2006;281(24):16700-6.
2006: Huankai Hu; Christopher J Endres; Cheng Chang; Umapathy Siddaramappa; Eun-Woo Lee; You-Jun Fei; Shirou Itagaki; Peter Swaan; Vadivel Ganapathy; Jashvant D Unadkat
Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3).
Molecular pharmacology 2006;69(5):1542-53.
2006: Peng Hsiao; Lucy Sasongko; Jeanne M Link; David A Mankoff; Mark Muzi; Ann C Collier; Jashvant D Unadkat
Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data.
The Journal of pharmacology and experimental therapeutics 2006;317(2):704-10.
2006: Honggang Wang; Lin Zhou; Anshul Gupta; R Robert Vethanayagam; Yi Zhang; Jashvant D Unadkat; Qingcheng Mao
Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E798-807.
2006: Christopher J Endres; Peng Hsiao; Francisco S Chung; Jashvant D Unadkat
The role of transporters in drug interactions.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;27(5):501-17.
2006: Anita A Mathias; Lillian Maggio-Price; Yurong Lai; Anshul Gupta; Jashvant D Unadkat
Changes in pharmacokinetics of anti-HIV protease inhibitors during pregnancy: the role of CYP3A and P-glycoprotein.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1202-9.
2005: Yi Zhang; Anshul Gupta; Honggang Wang; Lin Zhou; R Robert Vethanayagam; Jashvant D Unadkat; Qingcheng Mao
BCRP transports dipyridamole and is inhibited by calcium channel blockers.
Pharmaceutical research 2005;22(12):2023-34.
2005: Anita A Mathias; Jane Hitti; Jashvant D Unadkat
P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(4):R963-9.
2005: Helen R Winter; Jashvant D Unadkat
Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):969-76.
2005: Lucy Sasongko; Jeanne M Link; Mark Muzi; David A Mankoff; Xiaodong Yang; Ann C Collier; Steven C Shoner; Jashvant D Unadkat
Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography.
Clinical pharmacology and therapeutics 2005;77(6):503-14.
2005: R Robert Vethanayagam; Honggang Wang; Anshul Gupta; Yi Zhang; Fred Lewis; Jashvant D Unadkat; Qingcheng Mao
Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(6):697-705.
2005: Christopher J Endres; Jashvant D Unadkat
Residues Met89 and Ser160 in the human equilibrative nucleoside transporter 1 affect its affinity for adenosine, guanosine, S6-(4-nitrobenzyl)-mercaptopurine riboside, and dipyridamole.
Molecular pharmacology 2005;67(3):837-44.
2005: Qingcheng Mao; Jashvant D Unadkat
Role of the breast cancer resistance protein (ABCG2) in drug transport.
The AAPS journal 2005;7(1):E118-33.
2005: Yurong Lai; Eun-Woo Lee; Carl C Ton; Shashi Vijay; Huixia Zhang; Jashvant D Unadkat
Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively.
American journal of physiology. Cell physiology 2005;288(1):C39-45.
2004: Nancy A Wade; Jashvant D Unadkat; Sharon Huang; David E Shapiro; Anita Mathias; Salih Yasin; Gregory Ciupak; D Heather Watts; Isaac Delke; Mobeen H Rathore; Jane Hitti; Lisa M Frenkel; Renee Samelson; Mary Elizabeth Smith; Lynne Mofenson; Sandra K Burchett
Pharmacokinetics and safety of stavudine in HIV-infected pregnant women and their infants: Pediatric AIDS Clinical Trials Group protocol 332.
The Journal of infectious diseases 2004;190(12):2167-74.
2004: Helen R Winter; Carol B Trapnell; John T Slattery; Mark Jacobson; Debra L Greenspan; Thomas Hooton; Jashvant D Unadkat
The effect of clarithromycin, fluconazole, and rifabutin on dapsone hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283).
Clinical pharmacology and therapeutics 2004;76(6):579-87.
2004: Helen R Winter; Carol B Trapnell; John T Slattery; Mark Jacobson; Debra L Greenspan; Thomas Hooton; Jashvant D Unadkat
The effect of clarithromycin, fluconazole, and rifabutin on sulfamethoxazole hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283).
Clinical pharmacology and therapeutics 2004;76(4):313-22.
2004: Qingcheng Mao; Gwenaëlle Conseil; Anshul Gupta; SUSAN COLE; Jashvant D Unadkat
Functional expression of the human breast cancer resistance protein in Pichia pastoris.
Biochemical and biophysical research communications 2004;320(3):730-7.
2004: Anshul Gupta; Yi Zhang; Jashvant D Unadkat; Qingcheng Mao
HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2).
The Journal of pharmacology and experimental therapeutics 2004;310(1):334-41.
2004: Christopher J Endres; Dhruba SenGupta; Jashvant D Unadkat
Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1.
The Biochemical journal 2004;380(Pt 1):131-7.
2004: Cheng Chang; Peter Swaan; LY Ngo; Pek Y Lum; SD Patil; Jashvant D Unadkat
Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1.
Molecular pharmacology 2004;65(3):558-70.
2004: Yurong Lai; Chung-Ming Tse; Jashvant D Unadkat
Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.
The Journal of biological chemistry 2004;279(6):4490-7.
2004: Dhruba SenGupta; Jashvant D Unadkat
Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep.
Biochemical pharmacology 2004;67(3):453-8.
2004: Jashvant D Unadkat; Amber Dahlin; Shashi Vijay
Placental drug transporters.
Current drug metabolism 2004;5(1):125-31.
2002: Yurong Lai; Aimee H Bakken; Jashvant D Unadkat
Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies.
The Journal of biological chemistry 2002;277(40):37711-7.
2002: Dhruba SenGupta; Pek Y Lum; Yurong Lai; Elena Shubochkina; Aimee H Bakken; Glenda Schneider; Jashvant D Unadkat
A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine.
Biochemistry 2002;41(5):1512-9.
2001: Rodney J Y Ho; Kay Larsen; Loren Kinman; C Sherbert; XY Wang; Eric E Finn; C Nosbisch; Ann Schmidt; David Anderson; Shiu-Lok Hu; Michael B Agy; Hans D Ochs; William R Morton; Jashvant D Unadkat
Characterization of a maternal-fetal HIV transmission model using pregnant macaques infected with HIV-2(287).
Journal of medical primatology 2001;30(3):131-40.
2001: A Weber; M Kaplan; S A Chughtai; L A Cohn; Arnold L. Smith; Jashvant D Unadkat
CYP3A inductive potential of the rifamycins, rifabutin and rifampin, in the rabbit.
Biopharmaceutics & drug disposition 2001;22(4):157-68.
2001: LY Ngo; SD Patil; Jashvant D Unadkat
Ontogenic and longitudinal activity of Na(+)-nucleoside transporters in the human intestine.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(3):G475-81.
2000: Rodney J Y Ho; Kay Larsen; Tot Bui; XY Wang; Arnd M Herz; C Sherbert; Eric E Finn; C Nosbisch; Ann Schmidt; David Anderson; Michael B Agy; William R Morton; Jashvant D Unadkat
Suppression of maternal virus load with zidovudine, didanosine, and indinavir combination therapy prevents mother-to-fetus HIV transmission in macaques.
Journal of acquired immune deficiency syndromes (1999) 2000;25(2):140-9.
2000: Helen R Winter; Y Wang; Jashvant D Unadkat
CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(8):865-8.
2000: SD Patil; LY Ngo; Jashvant D Unadkat
Structure-inhibitory profiles of nucleosides for the human intestinal N1 and N2 Na+-nucleoside transporters.
Cancer chemotherapy and pharmacology 2000;46(5):394-402.
2000: Pek Y Lum; LY Ngo; Aimee H Bakken; Jashvant D Unadkat
Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles.
Cancer chemotherapy and pharmacology 2000;45(4):273-8.
1999: Y Wang; Elizabeth Livingston; S Patil; R E McKinney; Arlene Bardeguez; Jorge Gandia; Mary J O'Sullivan; P Clax; Sharon Huang; Jashvant D Unadkat
Pharmacokinetics of didanosine in antepartum and postpartum human immunodeficiency virus--infected pregnant women and their neonates: an AIDS clinical trials group study.
The Journal of infectious diseases 1999;180(5):1536-41.
1999: Ying Wang; Jashvant D Unadkat
Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes.
Biopharmaceutics & drug disposition 1999;20(7):341-6.
1999: L Y Ngo; Ram Yogev; Wayne M Dankner; WALTER HUGHES; S Burchett; J Xu; B Sadler; Jashvant D Unadkat
Pharmacokinetics of azithromycin administered alone and with atovaquone in human immunodeficiency virus-infected children. The ACTG 254 Team.
Antimicrobial agents and chemotherapy 1999;43(6):1516-9.
1999: Tove tuntland; A Odinecs; C M Pereira; C Nosbisch; Jashvant D Unadkat
In vitro models to predict the in vivo mechanism, rate, and extent of placental transfer of dideoxynucleoside drugs against human immunodeficiency virus.
American journal of obstetrics and gynecology 1999;180(1 Pt 1):198-206.
1998: SD Patil; LY Ngo; P Glue; Jashvant D Unadkat
Intestinal absorption of ribavirin is preferentially mediated by the Na+-nucleoside purine (N1) transporter.
Pharmaceutical research 1998;15(6):950-2.
1998: James C Ha; C Nosbisch; Janis L Abkowitz; S H Conrad; N K Mottet; Gerald C Ruppenthal; RL Robinette; Gene P Sackett; Jashvant D Unadkat
Fetal, infant, and maternal toxicity of zidovudine (azidothymidine) administered throughout pregnancy in Macaca nemestrina.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;18(1):27-38.
1998: Tove tuntland; A Odinecs; C Nosbisch; Jashvant D Unadkat
In vivo maternal-fetal-amniotic fluid pharmacokinetics of zidovudine in the pigtailed macaque: comparison of steady-state and single-dose regimens.
The Journal of pharmacology and experimental therapeutics 1998;285(1):54-62.
1998: D Hickman; J Pope; SD Patil; Giannoulis Fakis; VA Smelt; LA Stanley; Mark Payton; Jashvant D Unadkat; Edith Sim
Expression of arylamine N-acetyltransferase in human intestine.
Gut 1998;42(3):402-9.
1998: D Hickman; J P Wang; Y Wang; Jashvant D Unadkat
Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(3):207-15.
1997: Tove tuntland; C Nosbisch; Jashvant D Unadkat
Effect of pregnancy, mode of administration and neonatal age on the pharmacokinetics of zalcitabine (2', 3'-dideoxycytidine) in the pigtailed macaque (Macaca nemestrina).
The Journal of antimicrobial chemotherapy 1997;40(5):687-93.
1997: G Chandrasena; R Giltay; SD Patil; Aimee H Bakken; Jashvant D Unadkat
Functional expression of human intestinal Na+-dependent and Na+-independent nucleoside transporters in Xenopus laevis oocytes.
Biochemical pharmacology 1997;53(12):1909-18.
1997: SD Patil; Jashvant D Unadkat
Sodium-dependent nucleoside transport in the human intestinal brush-border membrane.
The American journal of physiology 1997;272(6 Pt 1):G1314-20.
1996: A Odinecs; C Pereira; C Nosbisch; Jashvant D Unadkat
Prenatal and postpartum pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) and didanosine (dideoxyinosine) in pigtailed macaques (Macaca nemestrina).
Antimicrobial agents and chemotherapy 1996;40(10):2423-5.
1996: Rodney J Y Ho; Michael B Agy; William R Morton; M Scheibel; Janela McClure; A Watson; Shiu-Lok Hu; C Nosbisch; N Dorofeeva; Jashvant D Unadkat
Development of a chronically catheterized maternal-fetal macaque model to study in utero mother-to-fetus HIV transmission: a preliminary report.
Journal of medical primatology 1996;25(3):218-24.
1996: A Odinecs; C Nosbisch; Jashvant D Unadkat
Zidovudine does not affect transplacental transfer or systemic clearance of stavudine (2',3'-didehydro-3'-deoxythymidine) in the pigtailed macaque (Macaca nemestrina).
Antimicrobial agents and chemotherapy 1996;40(6):1569-71.
1996: A K Mitra; Kenneth E Thummel; Thomas F Kalhorn; Evan D Kharasch; Jashvant D Unadkat; John T Slattery
Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers.
Clinical pharmacology and therapeutics 1996;59(3):332-40.
1996: Tove tuntland; C Nosbisch; W L Baughman; J Massarella; Jashvant D Unadkat
Mechanism and rate of placental transfer of zalcitabine (2',3'-dideoxycytidine) in Macaca nemestrina.
American journal of obstetrics and gynecology 1996;174(3):856-63.
1996: A Odinecs; C Nosbisch; R D Keller; W L Baughman; Jashvant D Unadkat
In vivo maternal-fetal pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in pigtailed macaques (Macaca nemestrina).
Antimicrobial agents and chemotherapy 1996;40(1):196-202.
1995: R D Keller; C Nosbisch; Jashvant D Unadkat
Pharmacokinetics of stavudine (2',3'-didehydro-3'-deoxythymidine) in the neonatal macaque (Macaca nemestrina).
Antimicrobial agents and chemotherapy 1995;39(12):2829-31.
1995: A K Mitra; Kenneth E Thummel; Thomas F Kalhorn; Evan D Kharasch; Jashvant D Unadkat; John T Slattery
Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.
Clinical pharmacology and therapeutics 1995;58(5):556-66.
1995: D Hickman; J R Palamanda; Jashvant D Unadkat; Edith Sim
Enzyme kinetic properties of human recombinant arylamine N-acetyltransferase 2 allotypic variants expressed in Escherichia coli.
Biochemical pharmacology 1995;50(5):697-703.
1995: Tot Bui; R Watanabe; B Kennedy; Jashvant D Unadkat; William R Morton; Rodney J Y Ho
Simian immunodeficiency virus infection of macaque primary placental cells.
AIDS research and human retroviruses 1995;11(8):955-61.
1995: Timothy W Schacker; Ann C Collier; R Coombs; Jashvant D Unadkat; I Fox; J Alam; J P Wang; E Eggert; Lawrence Corey
Phase I study of high-dose, intravenous rsCD4 in subjects with advanced HIV-1 infection.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1995;9(2):145-52.
1995: J R Palamanda; D Hickman; A Ward; Edith Sim; M Romkes-Sparks; Jashvant D Unadkat
Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(4):473-7.
1995: C M Pereira; C Nosbisch; W L Baughman; Jashvant D Unadkat
Effect of zidovudine on transplacental pharmacokinetics of ddI in the pigtailed macaque (Macaca nemestrina).
Antimicrobial agents and chemotherapy 1995;39(2):343-5.
1994: M Qian; G Chandrasena; Rodney J Y Ho; Jashvant D Unadkat
Comparison of rates of intracellular metabolism of zidovudine in human and primate peripheral blood mononuclear cells.
Antimicrobial agents and chemotherapy 1994;38(10):2398-403.
1994: M Qian; Tot Bui; Rodney J Y Ho; Jashvant D Unadkat
Metabolism of 3'-azido-3'-deoxythymidine (AZT) in human placental trophoblasts and Hofbauer cells.
Biochemical pharmacology 1994;48(2):383-9.
1994: J P Wang; Jashvant D Unadkat; S McNamara; T A O'Sullivan; Arnold L. Smith; William F Trager; Bonnie W Ramsey
Disposition of drugs in cystic fibrosis. VI. In vivo activity of cytochrome P450 isoforms involved in the metabolism of (R)-warfarin (including P450 3A4) is not enhanced in cystic fibrosis.
Clinical pharmacology and therapeutics 1994;55(5):528-34.
1994: R M Hutabarat; Arnold L. Smith; Jashvant D Unadkat
Disposition of drugs in cystic fibrosis. VII. Acetylation of sulfamethoxazole in blood cells: in vitro-in vivo correlation and characterization of its kinetics of acetylation in lymphocytes.
Clinical pharmacology and therapeutics 1994;55(4):427-33.
1994: C M Pereira; C Nosbisch; Jashvant D Unadkat
Pharmacokinetics of dideoxyinosine in neonatal pigtailed macaques.
Antimicrobial agents and chemotherapy 1994;38(4):787-9.
1994: C M Pereira; C Nosbisch; H R Winter; W L Baughman; Jashvant D Unadkat
Transplacental pharmacokinetics of dideoxyinosine in pigtailed macaques.
Antimicrobial agents and chemotherapy 1994;38(4):781-6.
1994: James C Ha; C Nosbisch; S H Conrad; G C Ruppenthal; Gene P Sackett; J Abkowitz; Jashvant D Unadkat
Fetal toxicity of zidovudine (azidothymidine) in Macaca nemestrina: preliminary observations.
Journal of acquired immune deficiency syndromes 1994;7(2):154-7.
1994: Tove tuntland; R J Ravasco; S al-Habet; Jashvant D Unadkat
Efflux of zidovudine and 2',3'-dideoxyinosine out of the cerebrospinal fluid when administered alone and in combination to Macaca nemestrina.
Pharmaceutical research 1994;11(2):312-7.
1994: S M al-Habet; C Nosbisch; T Williamson; C C Tsai; Jashvant D Unadkat
Interaction of zidovudine (azidothymidine) with isoprinosine and probenecid in Macaca fascicularis.
Pharmaceutical research 1994;11(1):181-3.
1993: T A O'Sullivan; J P Wang; Jashvant D Unadkat; S M al-Habet; William F Trager; Arnold L. Smith; S McNamara; Moira L Aitken
Disposition of drugs in cystic fibrosis. V. In vivo CYP2C9 activity as probed by (S)-warfarin is not enhanced in cystic fibrosis.
Clinical pharmacology and therapeutics 1993;54(3):323-8.
1993: J P Wang; Jashvant D Unadkat; S M al-Habet; T A O'Sullivan; J Williams-Warren; Arnold L. Smith; Bonnie W Ramsey
Disposition of drugs in cystic fibrosis. IV. Mechanisms for enhanced renal clearance of ticarcillin.
Clinical pharmacology and therapeutics 1993;54(3):293-302.
1993: A Lopez-Anaya; Jashvant D Unadkat; D F Calkins; Arnold L. Smith
Effect of age on distribution of zidovudine (azidothymidine) into the cerebrospinal fluid of Macaca nemestrina.
Pharmaceutical research 1993;10(9):1338-40.
1993: Tot Bui; D Bark; M Perkins; H Vu; Jashvant D Unadkat; Rodney J Y Ho
Effect of zidovudine on human placental trophoblast and Hofbauer cell functions.
Journal of acquired immune deficiency syndromes 1993;6(2):120-6.
1992: R J Ravasco; Jashvant D Unadkat; Che-Chung Tsai; C Nosbisch
Pharmacokinetics of dideoxyinosine in pigtailed macaques (Macaca nemestrina) after intravenous and subcutaneous administration.
Journal of acquired immune deficiency syndromes 1992;5(10):1016-8.
1992: R J Ravasco; Jashvant D Unadkat; Che-Chung Tsai
A high-performance liquid chromatographic assay for dideoxyinosine in monkey plasma and urine.
Journal of pharmaceutical sciences 1992;81(7):690-1.
1991: R M Hutabarat; Jashvant D Unadkat; P Kushmerick; Moira L Aitken; John T Slattery; Arnold L. Smith
Disposition of drugs in cystic fibrosis. III. Acetaminophen.
Clinical pharmacology and therapeutics 1991;50(6):695-701.
1991: T A O'Sullivan; L A Bauer; J R Horn; Brenda K Zierler; D Eugene Strandness; J Williams-Warren; Arnold L. Smith; Jashvant D Unadkat
Disposition of drugs in cystic fibrosis. II. Hepatic blood flow.
Clinical pharmacology and therapeutics 1991;50(4):450-5.
1991: R M Hutabarat; Jashvant D Unadkat; C Sahajwalla; S McNamara; Bonnie W Ramsey; Arnold L. Smith
Disposition of drugs in cystic fibrosis. I. Sulfamethoxazole and trimethoprim.
Clinical pharmacology and therapeutics 1991;49(4):402-9.
1991: A Lopez-Anaya; Jashvant D Unadkat; L A Schumann; Arnold L. Smith
Pharmacokinetics of zidovudine (azidothymidine). III. Effect of pregnancy.
Journal of acquired immune deficiency syndromes 1991;4(1):64-8.
1990: A Lopez-Anaya; Jashvant D Unadkat; L A Schumann
Simple and effective procedure for complete urine collection from infant macaques (Macaca nemestrina).
Journal of pharmacological methods 1990;24(2):105-9.
1990: A Lopez-Anaya; Jashvant D Unadkat; L A Schumann; Arnold L. Smith
Pharmacokinetics of zidovudine (azidothymidine). I. Transplacental transfer.
Journal of acquired immune deficiency syndromes 1990;3(10):959-64.
1990: A Lopez-Anaya; Jashvant D Unadkat; L A Schumann; Arnold L. Smith
Pharmacokinetics of zidovudine (azidothymidine). II. Development of metabolic and renal clearance pathways in the neonate.
Journal of acquired immune deficiency syndromes 1990;3(11):1052-8.
1989: Jashvant D Unadkat; J P Wang; D Pulham; R L Semmes
Dose-ranging pharmacokinetics of zidovudine (azidothymidine) in the rat.
Pharmaceutical research 1989;6(8):734-6.