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Emil Unanue

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Belizaire Roger; Unanue Emil R
Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation.
Carrero Javier A; Calderon Boris; Vivanco-Cid Hector; Unanue Emil R
Recombinant Listeria monocytogenes expressing a cell wall-associated listeriolysin O is weakly virulent but immunogenic.
Chang Kuan Y; Unanue Emil R
Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells.

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All Publications

2009: Belizaire Roger; Unanue Emil R
Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17463-8.
2009: Carrero Javier A; Calderon Boris; Vivanco-Cid Hector; Unanue Emil R
Recombinant Listeria monocytogenes expressing a cell wall-associated listeriolysin O is weakly virulent but immunogenic.
Infection and immunity 2009;77(10):4371-82.
2009: Chang Kuan Y; Unanue Emil R
Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells.
International immunology 2009;21(6):705-13.
2009: Aoshi Taiki; Carrero Javier A; Konjufca Vjollca; Koide Yukio; Unanue Emil R; Miller Mark J
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen.
European journal of immunology 2009;39(2):417-25.
2008: Hildner Kai; Edelson Brian T; Purtha Whitney E; Diamond Mark; Matsushita Hirokazu; Kohyama Masako; Calderon Boris; Schraml Barbara U; Unanue Emil R; Diamond Michael S; Schreiber Robert D; Murphy Theresa L; Murphy Kenneth M
Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity.
Science (New York, N.Y.) 2008;322(5904):1097-100.
2008: Calderon Boris; Suri Anish; Pan Xiaoou O; Mills Jason C; Unanue Emil R
IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6964-74.
2008: Carrero Javier A; Vivanco-Cid Hector; Unanue Emil R
Granzymes drive a rapid listeriolysin O-induced T cell apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1365-74.
2008: Levisetti Matteo G; Lewis Danna M; Suri Anish; Unanue Emil R
Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice.
Diabetes 2008;57(7):1852-60.
2008: Calderon Boris; Suri Anish; Miller Mark J; Unanue Emil R
Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6121-6.
2008: Suri Anish; Walters James J; Rohrs Henry W; Gross Michael L; Unanue Emil R
First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3849-56.
2008: Unanue Emil R; McCluskey James
Dressing for the occasion: APCs make antigens presentable.
Current opinion in immunology 2008;20(1):49-51.
2008: Suri Anish; Levisetti Matteo G; Unanue Emil R
Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?
Current opinion in immunology 2008;20(1):105-10.
2008: Akilesh Shreeram; Huber Tobias B; Wu Hui; Wang Gary; Hartleben Björn; Kopp Jeffrey B; Miner Jeffrey H; Roopenian Derry C; Unanue Emil R; Shaw Andrey S
Podocytes use FcRn to clear IgG from the glomerular basement membrane.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(3):967-72.
2008: McDevitt Hugh O; Unanue Emil R
Autoimmune diabetes mellitus--much progress, but many challenges.
Advances in immunology 2008;100():1-12.
2007: Unanue Emil R
Viral infections and nonspecific protection--good or bad?
The New England journal of medicine 2007;357(13):1345-6.
2007: Ziegler Kirk; Unanue Emil R
Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J. Immunol. 1981. 127: 1869-1875.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):5-11.
2007: Levisetti Matteo G; Suri Anish; Petzold Shirley J; Unanue Emil R
The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6051-7.
2007: Chang Kuan Y; Suri Anish; Unanue Emil R
Predicting peptides bound to I-Ag7 class II histocompatibility molecules using a novel expectation-maximization alignment algorithm.
Proteomics 2007;7(3):367-77.
2007: Unanue Emil R
Ito cells, stellate cells, and myofibroblasts: new actors in antigen presentation.
Immunity 2007;26(1):9-10.
2007: Lovitch Scott B; Esparza Thomas J; Schweitzer George; Herzog Jeremy; Unanue Emil R
Activation of type B T cells after protein immunization reveals novel pathways of in vivo presentation of peptides.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):122-33.
2007: Carrero Javier A; Unanue Emil R
Impact of lymphocyte apoptosis on the innate immune stages of infection.
Immunologic research 2007;38(1-3):333-41.
2006: Calderon Boris; Suri Anish; Unanue Emil R
In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.
The American journal of pathology 2006;169(6):2137-47.
2006: Unanue Emil R
From antigen processing to peptide-MHC binding.
Nature immunology 2006;7(12):1277-9.
2006: Carrero Javier A; Unanue Emil R
Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens.
Trends in immunology 2006;27(11):497-503.
2006: Ireland Jamie; Herzog Jeremy; Unanue Emil R
Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1421-5.
2006: Carrero Javier A; Calderon Boris; Unanue Emil R
Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.
The Journal of experimental medicine 2006;203(4):933-40.
2006: Suri Anish; Calderon Boris; Esparza Thomas J; Frederick Katherine; Bittner Patrice; Unanue Emil R
Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.
Science (New York, N.Y.) 2006;311(5768):1778-80.
2006: Lovitch Scott B; Pu Zheng; Unanue Emil R
Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2958-68.
2006: Suri Anish; Walters James J; Levisetti Matteo G; Gross Michael L; Unanue Emil R
Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells.
European journal of immunology 2006;36(3):544-57.
2006: Suri Anish; Lovitch Scott B; Unanue Emil R
The wide diversity and complexity of peptides bound to class II MHC molecules.
Current opinion in immunology 2006;18(1):70-7.
2005: Lovitch Scott B; Unanue Emil R
Conformational isomers of a peptide-class II major histocompatibility complex.
Immunological reviews 2005;207():293-313.
2005: Byersdorfer Craig A; Schweitzer George G; Unanue Emil R
Diabetes is predicted by the beta cell level of autoantigen.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4347-54.
2005: Babbitt Bruce P; Allen Paul M; Matsueda Gary; Haber Edgar; Unanue Emil R
Binding of immunogenic peptides to Ia histocompatibility molecules. 1985.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4163-5.
2005: Suri Anish; Walters James J; Gross Michael L; Unanue Emil R
Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity.
The Journal of clinical investigation 2005;115(8):2268-76.
2005: Herzog Jeremy; Maekawa Yoichi; Cirrito Thomas P; Illian Beverly S; Unanue Emil R
Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):7928-33.
2005: Suri Anish; Unanue Emil R
The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection.
Advances in immunology 2005;88():235-65.
2005: Unanue Emil; Byersdorfer Craig; Carrero Javier; Levisetti Matteo; Lovitch Scott; Pu Zheng; Suri Anish
Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?
Immunologic research 2005;32(1-3):267-92.
2004: Levisetti Matteo G; Suri Anish; Frederick Katherine; Unanue Emil R
Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes.
Diabetes 2004;53(12):3115-9.
2004: Byersdorfer Craig A; Dipaolo Richard J; Petzold Shirley J; Unanue Emil R
Following immunization antigen becomes concentrated in a limited number of APCs including B cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6627-34.
2004: Carrero Javier A; Calderon Boris; Unanue Emil R
Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.
The Journal of experimental medicine 2004;200(4):535-40.
2004: Pu Zheng; Lovitch Scott B; Bikoff Elizabeth K; Unanue Emil R
T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.
Immunity 2004;20(4):467-76.
2004: Carrero Javier A; Calderon Boris; Unanue Emil R
Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4866-74.
2004: Suri Anish; Shimizu Jun; Katz Jonathan D; Sakaguchi Shimon; Unanue Emil R; Kanagawa Osami
Regulation of autoimmune diabetes by non-islet-specific T cells - a role for the glucocorticoid-induced TNF receptor.
European journal of immunology 2004;34(2):447-54.
2003: Levisetti Matteo G; Suri Anish; Vidavsky Ilan; Gross Michael L; Kanagawa Osami; Unanue Emil R
Autoantibodies and CD4 T cells target a beta cell retroviral envelope protein in non-obese diabetic mice.
International immunology 2003;15(12):1473-83.
2003: Lovitch Scott B; Petzold Shirley J; Unanue Emil R
Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(5):2183-6.
2003: Mogemark Mickael; Cirrito Thomas P; Sjölin Petter; Unanue Emil R; Kihlberg Jan
Influence of saccharide size on the cellular immune response to glycopeptides.
Organic & biomolecular chemistry 2003;1(12):2063-9.
2003: Unanue Emil R
Intracellular pathogens and antigen presentation-new challenges with Legionella pneumophila.
Immunity 2003;18(6):722-4.
2003: Veeraswamy Ravi K; Cella Marina; Colonna Marco; Unanue Emil R
Dendritic cells process and present antigens across a range of maturation states.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5367-72.
2003: Kim Jeong M; Wu Hui; Green Gopa; Winkler Cheryl A; Kopp Jeffrey B; Miner Jeffrey H; Unanue Emil R; Shaw Andrey S
CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility.
Science (New York, N.Y.) 2003;300(5623):1298-300.
2003: Suri Anish; Walters James J; Kanagawa Osami; Gross Michael L; Unanue Emil R
Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5330-5.
2003: Lovitch Scott B; Walters James J; Gross Michael L; Unanue Emil R
APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4155-60.
2003: Krug Anne; Veeraswamy Ravi; Pekosz Andrew; Kanagawa Osami; Unanue Emil R; Colonna Marco; Cella Marina
Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells.
The Journal of experimental medicine 2003;197(7):899-906.
2002: Velazquez Carlos; Vidavsky Ilan; van der Drift Koen; Gross Michael L; Unanue Emil R
Chemical identification of a low abundance lysozyme peptide family bound to I-Ak histocompatibility molecules.
The Journal of biological chemistry 2002;277(45):42514-22.
2002: Mandik-Nayak Laura; Wipke Brian T; Shih Fei F; Unanue Emil R; Allen Paul M
Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14368-73.
2002: Edelson Brian T; Unanue Emil R
MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3869-75.
2002: DiPaolo Richard J; Unanue Emil R
Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):2832-6.
2002: Unanue Emil R
Perspective on antigen processing and presentation.
Immunological reviews 2002;185():86-102.
2002: DiPaolo Richard J; Unanue Emil R
Cutting edge: chemical dominance does not relate to immunodominance: studies of the CD4+ T cell response to a model antigen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):1-4.
2002: Pu Zheng; Carrero Javier A; Unanue Emil R
Distinct recognition by two subsets of T cells of an MHC class II-peptide complex.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8844-9.
2002: Suri Anish; Vidavsky Ilan; van der Drift Koen; Kanagawa Osami; Gross Michael L; Unanue Emil R
In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1235-43.
2001: DiPaolo R J; Unanue E R
The level of peptide-MHC complex determines the susceptibility to autoimmune diabetes: studies in HEL transgenic mice.
European journal of immunology 2001;31(12):3453-9.
2001: Cirrito T P; Pu Z; Deck M B; Unanue E R
Deamidation of asparagine in a major histocompatibility complex-bound peptide affects T cell recognition but does not explain type B reactivity.
The Journal of experimental medicine 2001;194(8):1165-70.
2001: Edelson B T; Unanue E R
Intracellular antibody neutralizes Listeria growth.
Immunity 2001;14(5):503-12.
2001: Peterson D A; DiPaolo R J; Kanagawa O; Unanue E R
Cutting edge: a single MHC anchor residue alters the conformation of a peptide-MHC complex inducing T cells that survive negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):5874-7.
2001: Velazquez C; DiPaolo R; Unanue E R
Quantitation of lysozyme peptides bound to class II MHC molecules indicates very large differences in levels of presentation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5488-94.
2000: Latek R R; Petzold S J; Unanue E R
Hindering auxiliary anchors are potent modulators of peptide binding and selection by I-Ak class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11460-5.
2000: Gugasyan R; Velazquez C; Vidavsky I; Deck B M; van der Drift K; Gross M L; Unanue E R
Independent selection by I-Ak molecules of two epitopes found in tandem in an extended polypeptide antigen.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3206-13.
2000: Edelson B T; Unanue E R
Immunity to Listeria infection.
Current opinion in immunology 2000;12(4):425-31.
2000: Latek R R; Suri A; Petzold S J; Nelson C A; Kanagawa O; Unanue E R; Fremont D H
Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice.
Immunity 2000;12(6):699-710.
1999: Latek R R; Unanue E R
Mechanisms and consequences of peptide selection by the I-Ak class II molecule.
Immunological reviews 1999;172():209-28.
1999: Peterson D A; DiPaolo R J; Kanagawa O; Unanue E R
Quantitative analysis of the T cell repertoire that escapes negative selection.
Immunity 1999;11(4):453-62.
1999: Carrasco-Marín E; Petzold S; Unanue E R
Two structural states of complexes of peptide and class II major histocompatibility complex revealed by photoaffinity-labeled peptides.
The Journal of biological chemistry 1999;274(44):31333-40.
1999: Edelson B T; Cossart P; Unanue E R
Cutting edge: paradigm revisited: antibody provides resistance to Listeria infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4087-90.
1999: Carrasco-Marin E; Kanagawa O; Unanue E R
The lack of consensus for I-A(g7)-peptide binding motifs: is there a requirement for anchor amino acid side chains?
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8621-6.
1999: Deck M B; Sjölin P; Unanue E R; Kihlberg J
MHC-restricted, glycopeptide-specific T cells show specificity for both carbohydrate and peptide residues.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4740-4.
1999: Peterson D A; DiPaolo R J; Kanagawa O; Unanue E R
Cutting edge: negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3117-20.
1999: Unanue E R
Rous-Whipple Award Lecture. Chemical features of peptide selection by the class II histocompatibility molecules.
The American journal of pathology 1999;154(3):651-64.
1998: Gugasyan R; Vidavsky I; Nelson C A; Gross M L; Unanue E R
Isolation and quantitation of a minor determinant of hen egg white lysozyme bound to I-Ak by using peptide-specific immunoaffinity.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6074-83.
1998: Kanagawa O; Vaupel B A; Xu G; Unanue E R; Katz J D
Thymic positive selection and peripheral activation of islet antigen-specific T cells: separation of two diabetogenic steps by an I-A(g7) class II MHC beta-chain mutant.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4489-92.
1998: Kanagawa O; Martin S M; Vaupel B A; Carrasco-Marin E; Unanue E R
Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1721-4.
1998: Bhardwaj V; Kanagawa O; Swanson P E; Unanue E R
Chronic Listeria infection in SCID mice: requirements for the carrier state and the dual role of T cells in transferring protection or suppression.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):376-84.
1997: Kanagawa O; Shimizu J; Unanue E R
The role of I-Ag7 beta chain in peptide binding and antigen recognition by T cells.
International immunology 1997;9(10):1523-6.
1997: Merrick J C; Edelson B T; Bhardwaj V; Swanson P E; Unanue E R
Lymphocyte apoptosis during early phase of Listeria infection in mice.
The American journal of pathology 1997;151(3):785-92.
1997: Unanue E R
Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell response.
Immunological reviews 1997;158():11-25.
1997: Unanue E R
Why listeriosis? A perspective on cellular immunity to infection.
Immunological reviews 1997;158():5-9.
1997: Carrasco-Marin E; Kanagawa O; Unanue E R
Insights into the chemistry and biology of the I-Ag7 class II molecule.
Research in immunology 1997;148(5):291-301.
1997: Dadaglio G; Nelson C A; Deck M B; Petzold S J; Unanue E R
Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody.
Immunity 1997;6(6):727-38.
1997: Dinauer M C; Deck M B; Unanue E R
Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5581-3.
1997: Dustin M L; Bromley S K; Kan Z; Peterson D A; Unanue E R
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3909-13.
1997: Parra-López C A; Lindner R; Vidavsky I; Gross M; Unanue E R
Presentation on class II MHC molecules of endogenous lysozyme targeted to the endocytic pathway.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2670-9.
1997: Unanue E R
Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistance.
Current opinion in immunology 1997;9(1):35-43.
1997: Nelson C A; Vidavsky I; Viner N J; Gross M L; Unanue E R
Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):628-33.
1996: Lindner R; Unanue E R
Distinct antigen MHC class II complexes generated by separate processing pathways.
The EMBO journal 1996;15(24):6910-20.
1996: Unanue E R
Macrophages, NK cells and neutrophils in the cytokine loop of Listeria resistance.
Research in immunology 1996;147(8-9):499-505.
1996: Dustin M L; Miller J M; Ranganath S; Vignali D A; Viner N J; Nelson C A; Unanue E R
TCR-mediated adhesion of T cell hybridomas to planar bilayers containing purified MHC class II/peptide complexes and receptor shedding during detachment.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2014-21.
1996: Nelson C A; Viner N J; Young S P; Petzold S J; Unanue E R
A negatively charged anchor residue promotes high affinity binding to the MHC class II molecule I-Ak.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):755-62.
1996: Nelson C A; Viner N J; Unanue E R
Appreciating the complexity of MHC class II peptide binding: lysozyme peptide and I-Ak.
Immunological reviews 1996;151():81-105.
1996: Viner N J; Nelson C A; Deck B; Unanue E R
Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2365-8.
1996: Nelson C A; Viner N; Young S; Petzold S; Benoist C; Mathis D; Unanue E R
Amino acid residues on the I-Ak alpha-chain required for the binding and stability of two antigenic peptides.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(1):176-82.
1996: Rogers H W; Callery M P; Deck B; Unanue E R
Listeria monocytogenes induces apoptosis of infected hepatocytes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):679-84.
1996: Carrasco-Marin E; Shimizu J; Kanagawa O; Unanue E R
The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):450-8.
1995: Shimizu J; Carrasco-Marin E; Kanagawa O; Unanue E R
Relationship between beta cell injury and antigen presentation in NOD mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):4095-9.
1995: Tripp C S; Kanagawa O; Unanue E R
Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3427-32.
1995: Deck B; Elofsson M; Kihlberg J; Unanue E R
Specificity of glycopeptide-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1074-8.
1995: Tripp C S; Beckerman K P; Unanue E R
Immune complexes inhibit antimicrobial responses through interleukin-10 production. Effects in severe combined immunodeficient mice during Listeria infection.
The Journal of clinical investigation 1995;95(4):1628-34.
1995: Viner N J; Nelson C A; Unanue E R
Identification of a major I-Ek-restricted determinant of hen egg lysozyme: limitations of lymph node proliferation studies in defining immunodominance and crypticity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2214-8.
1994: Nelson C A; Petzold S J; Unanue E R
Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell.
Nature 1994;371(6494):250-2.
1994: Rogers H W; Tripp C S; Schreiber R D; Unanue E R
Endogenous IL-1 is required for neutrophil recruitment and macrophage activation during murine listeriosis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2093-101.
1994: Tripp C S; Gately M K; Hakimi J; Ling P; Unanue E R
Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1883-7.
1993: Rogers H W; Unanue E R
Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice.
Infection and immunity 1993;61(12):5090-6.
1993: Corbett J A; Mikhael A; Shimizu J; Frederick K; Misko T P; McDaniel M L; Kanagawa O; Unanue E R
Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8992-5.
1993: Harding C V; Kihlberg J; Elofsson M; Magnusson G; Unanue E R
Glycopeptides bind MHC molecules and elicit specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2419-25.
1993: Shimizu J; Kanagawa O; Unanue E R
Presentation of beta-cell antigens to CD4+ and CD8+ T cells of non-obese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1723-30.
1993: Tripp C S; Wolf S F; Unanue E R
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3725-9.
1993: Nelson C A; Petzold S J; Unanue E R
Identification of two distinct properties of class II major histocompatibility complex-associated peptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1227-31.
1993: Beckerman K P; Rogers H W; Corbett J A; Schreiber R D; McDaniel M L; Unanue E R
Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):888-95.
1992: Nelson C A; Roof R W; McCourt D W; Unanue E R
Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7380-3.
1992: Ulaeto D; Lacy P E; Kipnis D M; Kanagawa O; Unanue E R
A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3927-31.
1992: Harding C V; Collins D; Unanue E R
Processing of liposome-encapsulated antigens targeted to specific subcellular compartments.
Research in immunology 1992;143(2):188-91.
1992: Rogers H W; Sheehan K C; Brunt L M; Dower S K; Unanue E R; Schreiber R D
Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(3):1011-5.
1992: Nelson C A; Harding C V; Unanue E R
Biochemical anatomy of antigen processing.
Cold Spring Harbor symposia on quantitative biology 1992;57():557-63.
1991: Collins D S; Unanue E R; Harding C V
Reduction of disulfide bonds within lysosomes is a key step in antigen processing.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(12):4054-9.
1991: Williams I R; Unanue E R
Characterization of accessory cell costimulation of Th1 cytokine synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3752-60.
1991: Harding C V; Collins D S; Kanagawa O; Unanue E R
Liposome-encapsulated antigens engender lysosomal processing for class II MHC presentation and cytosolic processing for class I presentation.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):2860-3.
1991: Hogquist K A; Nett M A; Unanue E R; Chaplin D D
Interleukin 1 is processed and released during apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8485-9.
1991: Hogquist K A; Unanue E R; Chaplin D D
Release of IL-1 from mononuclear phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(7):2181-6.
1991: Harding C V; Unanue E R
Modulation of antigen presentation and peptide-MHC-specific, LFA-1-dependent T cell-macrophage adhesion.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):767-73.
1991: Wherry J C; Schreiber R D; Unanue E R
Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli.
Infection and immunity 1991;59(5):1709-15.
1991: Harding C V; Roof R W; Allen P M; Unanue E R
Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2740-4.
1991: Duncan L M; Meegan L S; Unanue E R
IL-1 gene expression in lymphoid tissues.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):565-71.
1991: Harding C V; Collins D S; Slot J W; Geuze H J; Unanue E R
Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells.
Cell 1991;64(2):393-401.
1990: Luescher I F; Unanue E R
Purification and photoaffinity labeling of the I-Ak histocompatibility molecule.
Journal of immunological methods 1990;135(1-2):233-45.
1990: Brunt L M; Portnoy D A; Unanue E R
Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3540-6.
1990: Harding C V; Unanue E R
Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation.
Nature 1990;346(6284):574-6.
1990: Luescher I F; Crimmins D L; Schwartz B D; Unanue E R
The sites in the I-Ak histocompatibility molecule photoaffinity labeled by an immunogenic lysozyme peptide.
The Journal of biological chemistry 1990;265(19):11177-84.
1990: Williams I R; Unanue E R
Costimulatory requirements of murine Th1 clones. The role of accessory cell-derived signals in responses to anti-CD3 antibody.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):85-93.
1990: Roof R W; Luescher I F; Unanue E R
Phospholipids enhance the binding of peptides to class II major histocompatibility molecules.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1735-9.
1990: Weaver C T; Unanue E R
The costimulatory function of antigen-presenting cells.
Immunology today 1990;11(2):49-55.
1990: Harding C V; Unanue E R
Low-temperature inhibition of antigen processing and iron uptake from transferrin: deficits in endosome functions at 18 degrees C.
European journal of immunology 1990;20(2):323-9.
1989: Hawrylowicz C M; Santoro S A; Platt F M; Unanue E R
Activated platelets express IL-1 activity.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):4015-8.
1989: Unanue E R; Cerottini J C
Antigen presentation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(13):2496-502.
1989: Lambert L E; Unanue E R
Analysis of the interaction of peptide hen egg white lysozyme (34-45) with the I-Ak molecule.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):802-7.
1989: Bancroft G J; Sheehan K C; Schreiber R D; Unanue E R
Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):127-30.
1989: Harding C V; Roof R W; Unanue E R
Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4230-4.
1989: Weaver C T; Duncan L M; Unanue E R
T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of TH1 and TH2 subsets.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(10):3469-76.
1989: Hawrylowicz C M; Duncan L M; Fuhlbrigge R C; Unanue E R
Regulation of antigen presentation. II. Anti-Ig and IL-2 induce IL-1 production by murine splenic B cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(10):3361-8.
1989: Harding C V; Unanue E R
Antigen processing and intracellular Ia. Possible roles of endocytosis and protein synthesis in Ia function.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):12-9.
1989: Unanue E R; Harding C V; Luescher I F; Roof R W
Antigen-binding function of class II MHC molecules.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():383-92.
1989: Fuhlbrigge R C; Hogquist K A; Unanue E R; Chaplin D D
Molecular biology and genetics of interleukin-1.
The Year in immunology 1989;5():21-37.
1989: Allen P M; Matsueda G R; Adams S; Freeman J; Roof R W; Lambert L; Unanue E R
Enhanced immunogenicity of a T cell immunogenic peptide by modifications of its N and C termini.
International immunology 1989;1(2):141-50.
1988: Harding C V; Leyva-Cobian F; Unanue E R
Mechanisms of antigen processing.
Immunological reviews 1988;106():77-92.
1988: Hawrylowicz C M; Unanue E R
Regulation of antigen-presentation-I. IFN-gamma induces antigen-presenting properties on B cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4083-8.
1988: Weaver C T; Hawrylowicz C M; Unanue E R
T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8181-5.
1988: Fuhlbrigge R C; Sheehan K C; Schreiber R D; Chaplin D D; Unanue E R
Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(8):2643-50.
1988: Leyva-Cobian F; Unanue E R
Intracellular interference with antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1445-50.
1988: Fuhlbrigge R C; Fine S M; Unanue E R; Chaplin D D
Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5649-53.
1988: Deschryver-Kecskemeti K; Bancroft G J; Bosma G C; Bosma M J; Unanue E R
Pathology of Listeria infection in murine severe combined immunodeficiency. A study by immunohistochemistry and electron microscopy.
Laboratory investigation; a journal of technical methods and pathology 1988;58(6):698-705.
1988: Luescher I F; Allen P M; Unanue E R
Binding of photoreactive lysozyme peptides to murine histocompatibility class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):871-4.
1987: Bancroft G J; Schreiber R D; Bosma G C; Bosma M J; Unanue E R
A T cell-independent mechanism of macrophage activation by interferon-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(4):1104-7.
1987: Allen P M; Babbitt B P; Unanue E R
T-cell recognition of lysozyme: the biochemical basis of presentation.
Immunological reviews 1987;98():171-87.
1987: Fuhlbrigge R C; Chaplin D D; Kiely J M; Unanue E R
Regulation of interleukin 1 gene expression by adherence and lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(11):3799-802.
1987: Unanue E R; Weaver C T; Fuhlbrigge R C; Kiely J M; Chaplin D D
Membrane IL-1: a key protein in antigen presentation.
Annales de l'Institut Pasteur. Immunology 1987;138(3):489-92.
1986: Bancroft G J; Bosma M J; Bosma G C; Unanue E R
Regulation of macrophage Ia expression in mice with severe combined immunodeficiency: induction of Ia expression by a T cell-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(1):4-9.

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