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Emil Unanue

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TOP 3
Jacques Neefjes; Emil R Unanue
The ever surprising field of antigen presentation.
James F Mohan; Emil R Unanue
A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity.
Chiao-Wen Yang; Emil R Unanue
Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process.

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All Publications

2013: Jacques Neefjes; Emil R Unanue
The ever surprising field of antigen presentation.
Molecular immunology 2013;55(2):105.
2013: James F Mohan; Emil R Unanue
A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity.
Molecular immunology 2013;55(2):166-8.
2013: Chiao-Wen Yang; Emil R Unanue
Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process.
The Journal of experimental medicine 2013;210(2):375-87.
2013: Javier A Carrero; Fadi Towfic; Maxim N Artyomov; Boris Calderon; Emil R Unanue
Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse.
PloS one 2013;8(3):e59701.
2012: James F Mohan; Emil R Unanue
Unconventional recognition of peptides by T cells and the implications for autoimmunity.
Nature reviews. Immunology 2012;12(10):721-8.
2012: Jamie M Ireland; Emil R Unanue
Processing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system.
Autophagy 2012;8(3):429-30.
2012: Boris Calderon; Emil R Unanue
Antigen presentation events in autoimmune diabetes.
Current opinion in immunology 2012;24(1):119-28.
2012: Javier A Carrero; Hector Vivanco-Cid; Emil R Unanue
Listeriolysin o is strongly immunogenic independently of its cytotoxic activity.
PloS one 2012;7(3):e32310.
2012: Javier A Carrero; Emil R Unanue
Mechanisms and immunological effects of apoptosis caused by Listeria monocytogenes.
Advances in immunology 2012;113():157-74.
2012: Emil R Unanue; Javier A Carrero
Studies with Listeria monocytogenes lead the way.
Advances in immunology 2012;113():1-5.
2011: James F Mohan; Shirley J Petzold; Emil R Unanue
Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.
The Journal of experimental medicine 2011;208(12):2375-83.
2011: Beverly S I Strong; Emil R Unanue
Presentation of type B peptide-MHC complexes from hen egg white lysozyme by TLR ligands and type I IFNs independent of H2-DM regulation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2193-201.
2011: Brian T Edelson; Katherine E Frederick; Kai Hildner; Wumesh KC; Mark J Miller; Taiki Aoshi; Roger Belizaire; Tara R Bradstreet; Javier A Carrero; Theresa L Murphy; Robert D Schreiber; Emil R Unanue; Kenneth M Murphy
CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.
Immunity 2011;35(2):236-48.
2011: Stephen A McCartney; william vermi; Silvia Lonardi; Cristina Rossini; Karel Otero; Boris Calderon; Susan Gilfillan; Michael S Diamond; Emil R Unanue; Marco COLONna
RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice.
The Journal of clinical investigation 2011;121(4):1497-507.
2011: Danielle F Atibalentja; Kenneth M Murphy; Emil R Unanue
Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1421-31.
2011: Boris Calderon; Carrero Javier; Mark J Miller; Emil R Unanue
Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1561-6.
2011: Boris Calderon; Carrero Javier; Mark J Miller; Emil R Unanue
Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1567-72.
2011: Brian T Edelson; Jeremy W Herzog; Kai Hildner; Theresa L Murphy; John H Russell; Julia Sim; Emil R Unanue; Wumesh KC; Tara R Bradstreet; Kenneth M Murphy
Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.
PloS one 2011;6(10):e25660.
2011: Emil R Unanue
Starting in immunology by way of immunopathology.
Annual review of pathology 2011;6():1-18.
2011: Emil R Unanue
Altered peptide ligands make their entry.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(1):7-8.
2010: Chiao-Wen Yang; Beverly S I Strong; Mark J Miller; Emil R Unanue
Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2927-34.
2010: James F Mohan; Matteo G Levisetti; Boris Calderon; Jeremy W Herzog; Shirley J Petzold; Emil R Unanue
Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes.
Nature immunology 2010;11(4):350-4.
2010: Wataru Ise; Masako Kohyama; Katherine M Nutsch; Hyang Mi Lee; Anish Suri; Emil R Unanue; Theresa L Murphy; Kenneth M Murphy
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
Nature immunology 2010;11(2):129-35.
2009: Danielle F Atibalentja; Craig A Byersdorfer; Emil R Unanue
Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7909-18.
2009: Roger Belizaire; Emil R Unanue
Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17463-8.
2009: Javier A Carrero; Boris Calderon; Hector Vivanco-Cid; Emil R Unanue
Recombinant Listeria monocytogenes expressing a cell wall-associated listeriolysin O is weakly virulent but immunogenic.
Infection and immunity 2009;77(10):4371-82.
2009: Kuan Y Chang; Emil R Unanue
Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells.
International immunology 2009;21(6):705-13.
2009: Taiki Aoshi; Javier A Carrero; Vjollca Konjufca; Yukio Koide; Emil R Unanue; Mark J Miller
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen.
European journal of immunology 2009;39(2):417-25.
2008: Boris Calderon; Anish Suri; Xiaoou O Pan; Jason C Mills; Emil R Unanue
IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6964-74.
2008: Kai Hildner; Brian T Edelson; Whitney E Purtha; Mark Diamond; Hirokazu Matsushita; Masako Kohyama; Boris Calderon; Barbara U Schraml; Emil R Unanue; Michael S Diamond; Robert D Schreiber; Theresa L Murphy; Kenneth M Murphy
Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity.
Science (New York, N.Y.) 2008;322(5904):1097-100.
2008: Carrero Javier; Hector Vivanco-Cid; Emil R Unanue
Granzymes drive a rapid listeriolysin O-induced T cell apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1365-74.
2008: Matteo G Levisetti; Danna M Lewis; Anish Suri; Emil R Unanue
Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice.
Diabetes 2008;57(7):1852-60.
2008: Boris Calderon; Anish Suri; Mark J Miller; Emil R Unanue
Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6121-6.
2008: Anish Suri; James J Walters; Henry W Rohrs; Michael L Gross; Emil R Unanue
First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3849-56.
2008: Emil R Unanue; James McCluskey
Dressing for the occasion: APCs make antigens presentable.
Current opinion in immunology 2008;20(1):49-51.
2008: Anish Suri; Matteo G Levisetti; Emil R Unanue
Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?
Current opinion in immunology 2008;20(1):105-10.
2008: Shreeram Akilesh; Tobias B Huber; Hui Wu; Gary Wang; Björn Hartleben; Jeffrey Kopp; Jeffrey H Miner; Derry C Roopenian; Emil R Unanue; Andrey S Shaw
Podocytes use FcRn to clear IgG from the glomerular basement membrane.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(3):967-72.
2008: Hugh O McDevitt; Emil R Unanue
Autoimmune diabetes mellitus--much progress, but many challenges.
Advances in immunology 2008;100():1-12.
2007: Emil R Unanue
Viral infections and nonspecific protection--good or bad?
The New England journal of medicine 2007;357(13):1345-6.
2007: Kirk Ziegler; Emil R Unanue
Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J. Immunol. 1981. 127: 1869-1875.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):5-11.
2007: Matteo G Levisetti; Anish Suri; Shirley J Petzold; Emil R Unanue
The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6051-7.
2007: Kuan Y Chang; Anish Suri; Emil R Unanue
Predicting peptides bound to I-Ag7 class II histocompatibility molecules using a novel expectation-maximization alignment algorithm.
Proteomics 2007;7(3):367-77.
2007: Carrero Javier; Emil R Unanue
Impact of lymphocyte apoptosis on the innate immune stages of infection.
Immunologic research 2007;38(1-3):333-41.
2007: Emil R Unanue
Ito cells, stellate cells, and myofibroblasts: new actors in antigen presentation.
Immunity 2007;26(1):9-10.
2007: Scott B Lovitch; Thomas J Esparza; George Schweitzer; Jeremy Herzog; Emil R Unanue
Activation of type B T cells after protein immunization reveals novel pathways of in vivo presentation of peptides.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):122-33.
2006: Boris Calderon; Anish Suri; Emil R Unanue
In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.
The American journal of pathology 2006;169(6):2137-47.
2006: Emil R Unanue
From antigen processing to peptide-MHC binding.
Nature immunology 2006;7(12):1277-9.
2006: Carrero Javier; Emil R Unanue
Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens.
Trends in immunology 2006;27(11):497-503.
2006: Jamie Ireland; Jeremy Herzog; Emil R Unanue
Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1421-5.
2006: Carrero Javier; Boris Calderon; Emil R Unanue
Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.
The Journal of experimental medicine 2006;203(4):933-40.
2006: Anish Suri; Boris Calderon; Thomas J Esparza; Katherine Frederick; Patrice Bittner; Emil R Unanue
Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.
Science (New York, N.Y.) 2006;311(5768):1778-80.
2006: Scott B Lovitch; Zheng Pu; Emil R Unanue
Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2958-68.
2006: Anish Suri; James J Walters; Matteo G Levisetti; Michael L Gross; Emil R Unanue
Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells.
European journal of immunology 2006;36(3):544-57.
2006: Anish Suri; Scott B Lovitch; Emil R Unanue
The wide diversity and complexity of peptides bound to class II MHC molecules.
Current opinion in immunology 2006;18(1):70-7.
2005: Scott B Lovitch; Emil R Unanue
Conformational isomers of a peptide-class II major histocompatibility complex.
Immunological reviews 2005;207():293-313.
2005: Craig A Byersdorfer; George Schweitzer; Emil R Unanue
Diabetes is predicted by the beta cell level of autoantigen.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4347-54.
2005: Bruce P Babbitt; Paul M Allen; Gary Matsueda; Edgar Haber; Emil R Unanue
Binding of immunogenic peptides to Ia histocompatibility molecules. 1985.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4163-5.
2005: Anish Suri; James J Walters; Michael L Gross; Emil R Unanue
Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity.
The Journal of clinical investigation 2005;115(8):2268-76.
2005: Jeremy Herzog; Yoichi Maekawa; Thomas P Cirrito; Beverly S Illian; Emil R Unanue
Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):7928-33.
2005: Anish Suri; Emil R Unanue
The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection.
Advances in immunology 2005;88():235-65.
2005: Emil R Unanue; Craig Byersdorfer; Carrero Javier; Matteo Levisetti; Scott B Lovitch; Zheng Pu; Anish Suri
Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?
Immunologic research 2005;32(1-3):267-92.
2004: Matteo G Levisetti; Anish Suri; Katherine Frederick; Emil R Unanue
Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes.
Diabetes 2004;53(12):3115-9.
2004: Craig A Byersdorfer; Richard DiPaolo; Shirley J Petzold; Emil R Unanue
Following immunization antigen becomes concentrated in a limited number of APCs including B cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6627-34.
2004: Carrero Javier; Boris Calderon; Emil R Unanue
Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.
The Journal of experimental medicine 2004;200(4):535-40.
2004: Carrero Javier; Boris Calderon; Emil R Unanue
Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4866-74.
2004: Zheng Pu; Scott B Lovitch; Elizabeth K Bikoff; Emil R Unanue
T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.
Immunity 2004;20(4):467-76.
2004: Anish Suri; Jun Shimizu; Jonathan D Katz; Shimon Sakaguchi; Emil R Unanue; Osami Kanagawa
Regulation of autoimmune diabetes by non-islet-specific T cells - a role for the glucocorticoid-induced TNF receptor.
European journal of immunology 2004;34(2):447-54.
2003: Matteo G Levisetti; Anish Suri; Ilan Vidavsky; Michael L Gross; Osami Kanagawa; Emil R Unanue
Autoantibodies and CD4 T cells target a beta cell retroviral envelope protein in non-obese diabetic mice.
International immunology 2003;15(12):1473-83.
2003: Scott B Lovitch; Shirley J Petzold; Emil R Unanue
Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(5):2183-6.
2003: Mickael Mogemark; Thomas P Cirrito; Petter Sjölin; Emil R Unanue; Jan Kihlberg
Influence of saccharide size on the cellular immune response to glycopeptides.
Organic & biomolecular chemistry 2003;1(12):2063-9.
2003: Emil R Unanue
Intracellular pathogens and antigen presentation-new challenges with Legionella pneumophila.
Immunity 2003;18(6):722-4.
2003: Ravi K Veeraswamy; Marina Cella; Marco COLONna; Emil R Unanue
Dendritic cells process and present antigens across a range of maturation states.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5367-72.
2003: Jeong M Kim; Hui Wu; Gopa Green; Cheryl A Winkler; Jeffrey Kopp; Jeffrey H Miner; Emil R Unanue; Andrey S Shaw
CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility.
Science (New York, N.Y.) 2003;300(5623):1298-300.
2003: Anish Suri; James J Walters; Osami Kanagawa; Michael L Gross; Emil R Unanue
Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5330-5.
2003: Scott B Lovitch; James J Walters; Michael L Gross; Emil R Unanue
APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4155-60.
2003: Anne Krug; Ravi K Veeraswamy; Andrew Pekosz; Osami Kanagawa; Emil R Unanue; Marco COLONna; Marina Cella
Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells.
The Journal of experimental medicine 2003;197(7):899-906.
2002: Carlos Velazquez; Ilan Vidavsky; Koen van der Drift; Michael L Gross; Emil R Unanue
Chemical identification of a low abundance lysozyme peptide family bound to I-Ak histocompatibility molecules.
The Journal of biological chemistry 2002;277(45):42514-22.
2002: Laura Mandik-Nayak; Brian T Wipke; Fei F Shih; Emil R Unanue; Paul M Allen
Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14368-73.
2002: Brian T Edelson; Emil R Unanue
MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3869-75.
2002: Richard DiPaolo; Emil R Unanue
Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):2832-6.
2002: Emil R Unanue
Perspective on antigen processing and presentation.
Immunological reviews 2002;185():86-102.
2002: Richard DiPaolo; Emil R Unanue
Cutting edge: chemical dominance does not relate to immunodominance: studies of the CD4+ T cell response to a model antigen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):1-4.
2002: Zheng Pu; Carrero Javier; Emil R Unanue
Distinct recognition by two subsets of T cells of an MHC class II-peptide complex.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8844-9.
2002: Anish Suri; Ilan Vidavsky; Koen van der Drift; Osami Kanagawa; Michael L Gross; Emil R Unanue
In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1235-43.
2001: Richard DiPaolo; Emil R Unanue
The level of peptide-MHC complex determines the susceptibility to autoimmune diabetes: studies in HEL transgenic mice.
European journal of immunology 2001;31(12):3453-9.
2001: Thomas P Cirrito; Zheng Pu; MB Deck; Emil R Unanue
Deamidation of asparagine in a major histocompatibility complex-bound peptide affects T cell recognition but does not explain type B reactivity.
The Journal of experimental medicine 2001;194(8):1165-70.
2001: Daniel A Peterson; Richard DiPaolo; Osami Kanagawa; Emil R Unanue
Cutting edge: a single MHC anchor residue alters the conformation of a peptide-MHC complex inducing T cells that survive negative selection.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):5874-7.
2001: Brian T Edelson; Emil R Unanue
Intracellular antibody neutralizes Listeria growth.
Immunity 2001;14(5):503-12.
2001: Carlos Velazquez; Richard DiPaolo; Emil R Unanue
Quantitation of lysozyme peptides bound to class II MHC molecules indicates very large differences in levels of presentation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5488-94.
2000: RR Latek; Shirley J Petzold; Emil R Unanue
Hindering auxiliary anchors are potent modulators of peptide binding and selection by I-Ak class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11460-5.
2000: R Gugasyan; Carlos Velazquez; Ilan Vidavsky; B M Deck; Koen van der Drift; Michael L Gross; Emil R Unanue
Independent selection by I-Ak molecules of two epitopes found in tandem in an extended polypeptide antigen.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3206-13.
2000: Brian T Edelson; Emil R Unanue
Immunity to Listeria infection.
Current opinion in immunology 2000;12(4):425-31.
2000: RR Latek; Anish Suri; Shirley J Petzold; C A Nelson; Osami Kanagawa; Emil R Unanue; daved fremont
Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice.
Immunity 2000;12(6):699-710.
1999: RR Latek; Emil R Unanue
Mechanisms and consequences of peptide selection by the I-Ak class II molecule.
Immunological reviews 1999;172():209-28.
1999: E Carrasco-Marín; Shirley J Petzold; Emil R Unanue
Two structural states of complexes of peptide and class II major histocompatibility complex revealed by photoaffinity-labeled peptides.
The Journal of biological chemistry 1999;274(44):31333-40.
1999: Brian T Edelson; P Cossart; Emil R Unanue
Cutting edge: paradigm revisited: antibody provides resistance to Listeria infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4087-90.
1999: Daniel A Peterson; Richard DiPaolo; Osami Kanagawa; Emil R Unanue
Quantitative analysis of the T cell repertoire that escapes negative selection.
Immunity 1999;11(4):453-62.
1999: E Carrasco-Marin; Osami Kanagawa; Emil R Unanue
The lack of consensus for I-A(g7)-peptide binding motifs: is there a requirement for anchor amino acid side chains?
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8621-6.
1999: MB Deck; Petter Sjölin; Emil R Unanue; Jan Kihlberg
MHC-restricted, glycopeptide-specific T cells show specificity for both carbohydrate and peptide residues.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4740-4.
1999: Daniel A Peterson; Richard DiPaolo; Osami Kanagawa; Emil R Unanue
Cutting edge: negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3117-20.
1999: Emil R Unanue
Rous-Whipple Award Lecture. Chemical features of peptide selection by the class II histocompatibility molecules.
The American journal of pathology 1999;154(3):651-64.
1998: R Gugasyan; Ilan Vidavsky; CA Nelson; Michael L Gross; Emil R Unanue
Isolation and quantitation of a minor determinant of hen egg white lysozyme bound to I-Ak by using peptide-specific immunoaffinity.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6074-83.
1998: Osami Kanagawa; Barbala A Vaupel; G Xu; Emil R Unanue; Jonathan D Katz
Thymic positive selection and peripheral activation of islet antigen-specific T cells: separation of two diabetogenic steps by an I-A(g7) class II MHC beta-chain mutant.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4489-92.
1998: Osami Kanagawa; S M Martin; Barbala A Vaupel; E Carrasco-Marin; Emil R Unanue
Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1721-4.
1998: V Bhardwaj; Osami Kanagawa; P E Swanson; Emil R Unanue
Chronic Listeria infection in SCID mice: requirements for the carrier state and the dual role of T cells in transferring protection or suppression.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):376-84.
1997: O Kanagawa; J Shimizu; Emil R Unanue
The role of I-Ag7 beta chain in peptide binding and antigen recognition by T cells.
International immunology 1997;9(10):1523-6.
1997: J C Merrick; Brian T Edelson; V Bhardwaj; P E Swanson; Emil R Unanue
Lymphocyte apoptosis during early phase of Listeria infection in mice.
The American journal of pathology 1997;151(3):785-92.
1997: Emil R Unanue
Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell response.
Immunological reviews 1997;158():11-25.
1997: Emil R Unanue
Why listeriosis? A perspective on cellular immunity to infection.
Immunological reviews 1997;158():5-9.
1997: M C Dinauer; MB Deck; Emil R Unanue
Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5581-3.
1997: E Carrasco-Marin; Osami Kanagawa; Emil R Unanue
Insights into the chemistry and biology of the I-Ag7 class II molecule.
Research in immunology 1997;148(5):291-301.
1997: G Dadaglio; C A Nelson; MB Deck; Shirley J Petzold; Emil R Unanue
Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody.
Immunity 1997;6(6):727-38.
1997: Michael L Dustin; Shannon K Bromley; Z Kan; Daniel A Peterson; Emil R Unanue
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3909-13.
1997: C A Parra-López; R Lindner; Ilan Vidavsky; M Gross; Emil R Unanue
Presentation on class II MHC molecules of endogenous lysozyme targeted to the endocytic pathway.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2670-9.
1997: Emil R Unanue
Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistance.
Current opinion in immunology 1997;9(1):35-43.
1997: CA Nelson; Ilan Vidavsky; N J Viner; Michael L Gross; Emil R Unanue
Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):628-33.
1996: R Lindner; Emil R Unanue
Distinct antigen MHC class II complexes generated by separate processing pathways.
The EMBO journal 1996;15(24):6910-20.
1996: Emil R Unanue
Macrophages, NK cells and neutrophils in the cytokine loop of Listeria resistance.
Research in immunology 1996;147(8-9):499-505.
1996: Michael L Dustin; J M Miller; Sheila Ranganath; D A Vignali; N J Viner; CA Nelson; Emil R Unanue
TCR-mediated adhesion of T cell hybridomas to planar bilayers containing purified MHC class II/peptide complexes and receptor shedding during detachment.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2014-21.
1996: CA Nelson; N J Viner; Stephen Young; S J Petzold; Emil R Unanue
A negatively charged anchor residue promotes high affinity binding to the MHC class II molecule I-Ak.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):755-62.
1996: CA Nelson; N J Viner; Emil R Unanue
Appreciating the complexity of MHC class II peptide binding: lysozyme peptide and I-Ak.
Immunological reviews 1996;151():81-105.
1996: N J Viner; CA Nelson; B Deck; Emil R Unanue
Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(7):2365-8.
1996: H W Rogers; M P Callery; B Deck; Emil R Unanue
Listeria monocytogenes induces apoptosis of infected hepatocytes.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):679-84.
1996: E Carrasco-Marin; J Shimizu; Osami Kanagawa; Emil R Unanue
The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):450-8.
1996: CA Nelson; N Viner; S Young; S Petzold; C Benoist; D Mathis; Emil R Unanue
Amino acid residues on the I-Ak alpha-chain required for the binding and stability of two antigenic peptides.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(1):176-82.
1995: J Shimizu; E Carrasco-Marin; Osami Kanagawa; Emil R Unanue
Relationship between beta cell injury and antigen presentation in NOD mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):4095-9.
1995: C S Tripp; Osami Kanagawa; Emil R Unanue
Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3427-32.
1995: B Deck; M Elofsson; Jan Kihlberg; Emil R Unanue
Specificity of glycopeptide-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1074-8.
1995: C S Tripp; Karen Beckerman; Emil R Unanue
Immune complexes inhibit antimicrobial responses through interleukin-10 production. Effects in severe combined immunodeficient mice during Listeria infection.
The Journal of clinical investigation 1995;95(4):1628-34.
1995: N J Viner; CA Nelson; Emil R Unanue
Identification of a major I-Ek-restricted determinant of hen egg lysozyme: limitations of lymph node proliferation studies in defining immunodominance and crypticity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2214-8.
1994: CA Nelson; S J Petzold; Emil R Unanue
Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell.
Nature 1994;371(6494):250-2.
1994: H W Rogers; C S Tripp; Robert D Schreiber; Emil R Unanue
Endogenous IL-1 is required for neutrophil recruitment and macrophage activation during murine listeriosis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):2093-101.
1994: C S Tripp; M K Gately; J Hakimi; P Ling; Emil R Unanue
Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1883-7.
1993: H W Rogers; Emil R Unanue
Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice.
Infection and immunity 1993;61(12):5090-6.
1993: John A Corbett; A Mikhael; J Shimizu; K Frederick; TP Misko; Michael L McDaniel; O Kanagawa; Emil R Unanue
Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8992-5.
1993: Clifford V Harding; Jan Kihlberg; M Elofsson; G Magnusson; Emil R Unanue
Glycopeptides bind MHC molecules and elicit specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2419-25.
1993: J Shimizu; O Kanagawa; Emil R Unanue
Presentation of beta-cell antigens to CD4+ and CD8+ T cells of non-obese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1723-30.
1993: C S Tripp; Stanley Wolf; Emil R Unanue
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3725-9.
1993: CA Nelson; S J Petzold; Emil R Unanue
Identification of two distinct properties of class II major histocompatibility complex-associated peptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1227-31.
1993: Karen Beckerman; H W Rogers; John A Corbett; Robert D Schreiber; Michael L McDaniel; Emil R Unanue
Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):888-95.
1992: CA Nelson; R W Roof; D W McCourt; Emil R Unanue
Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7380-3.
1992: D Ulaeto; P E Lacy; D M Kipnis; O Kanagawa; Emil R Unanue
A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3927-31.
1992: C V Harding; D Collins; Emil R Unanue
Processing of liposome-encapsulated antigens targeted to specific subcellular compartments.
Research in immunology 1992;143(2):188-91.
1992: H W Rogers; Kathleen C F Sheehan; L M Brunt; S K Dower; Emil R Unanue; Robert D Schreiber
Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(3):1011-5.
1992: C A Nelson; C V Harding; Emil R Unanue
Biochemical anatomy of antigen processing.
Cold Spring Harbor symposia on quantitative biology 1992;57():557-63.
1991: D S Collins; Emil R Unanue; Clifford V Harding
Reduction of disulfide bonds within lysosomes is a key step in antigen processing.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(12):4054-9.
1991: Ifor Williams; Emil R Unanue
Characterization of accessory cell costimulation of Th1 cytokine synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3752-60.
1991: Clifford V Harding; D S Collins; O Kanagawa; Emil R Unanue
Liposome-encapsulated antigens engender lysosomal processing for class II MHC presentation and cytosolic processing for class I presentation.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):2860-3.
1991: K A Hogquist; M A Nett; Emil R Unanue; D D Chaplin
Interleukin 1 is processed and released during apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8485-9.
1991: K A Hogquist; Emil R Unanue; D D Chaplin
Release of IL-1 from mononuclear phagocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(7):2181-6.
1991: Clifford V Harding; Emil R Unanue
Modulation of antigen presentation and peptide-MHC-specific, LFA-1-dependent T cell-macrophage adhesion.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):767-73.
1991: J C Wherry; Robert D Schreiber; Emil R Unanue
Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli.
Infection and immunity 1991;59(5):1709-15.
1991: C V Harding; R W Roof; P M Allen; Emil R Unanue
Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2740-4.
1991: Clifford V Harding; D S Collins; J W Slot; H J Geuze; Emil R Unanue
Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells.
Cell 1991;64(2):393-401.
1991: L M Duncan; L S Meegan; Emil R Unanue
IL-1 gene expression in lymphoid tissues.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):565-71.
1990: I F Luescher; Emil R Unanue
Purification and photoaffinity labeling of the I-Ak histocompatibility molecule.
Journal of immunological methods 1990;135(1-2):233-45.
1990: L M Brunt; D A Portnoy; Emil R Unanue
Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3540-6.
1990: Clifford V Harding; Emil R Unanue
Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation.
Nature 1990;346(6284):574-6.
1990: I F Luescher; D L Crimmins; B D Schwartz; Emil R Unanue
The sites in the I-Ak histocompatibility molecule photoaffinity labeled by an immunogenic lysozyme peptide.
The Journal of biological chemistry 1990;265(19):11177-84.
1990: Ifor Williams; Emil R Unanue
Costimulatory requirements of murine Th1 clones. The role of accessory cell-derived signals in responses to anti-CD3 antibody.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):85-93.
1990: R W Roof; I F Luescher; Emil R Unanue
Phospholipids enhance the binding of peptides to class II major histocompatibility molecules.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1735-9.
1990: C T Weaver; Emil R Unanue
The costimulatory function of antigen-presenting cells.
Immunology today 1990;11(2):49-55.
1990: Clifford V Harding; Emil R Unanue
Low-temperature inhibition of antigen processing and iron uptake from transferrin: deficits in endosome functions at 18 degrees C.
European journal of immunology 1990;20(2):323-9.
1989: C M Hawrylowicz; S A Santoro; F M Platt; Emil R Unanue
Activated platelets express IL-1 activity.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):4015-8.
1989: Emil R Unanue; J C Cerottini
Antigen presentation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(13):2496-502.
1989: L E Lambert; Emil R Unanue
Analysis of the interaction of peptide hen egg white lysozyme (34-45) with the I-Ak molecule.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):802-7.
1989: G J Bancroft; Kathleen C F Sheehan; Robert D Schreiber; Emil R Unanue
Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):127-30.
1989: C V Harding; R W Roof; Emil R Unanue
Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4230-4.
1989: C T Weaver; L M Duncan; Emil R Unanue
T cell induction of macrophage IL-1 during antigen presentation. Characterization of a lymphokine mediator and comparison of TH1 and TH2 subsets.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(10):3469-76.
1989: C M Hawrylowicz; L M Duncan; R C Fuhlbrigge; Emil R Unanue
Regulation of antigen presentation. II. Anti-Ig and IL-2 induce IL-1 production by murine splenic B cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(10):3361-8.
1989: Clifford V Harding; Emil R Unanue
Antigen processing and intracellular Ia. Possible roles of endocytosis and protein synthesis in Ia function.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):12-9.
1989: Emil R Unanue; C V Harding; I F Luescher; R W Roof
Antigen-binding function of class II MHC molecules.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():383-92.
1989: R C Fuhlbrigge; K A Hogquist; Emil R Unanue; D D Chaplin
Molecular biology and genetics of interleukin-1.
The Year in immunology 1989;5():21-37.
1989: P M Allen; G R Matsueda; S Adams; J Freeman; R W Roof; L Lambert; Emil R Unanue
Enhanced immunogenicity of a T cell immunogenic peptide by modifications of its N and C termini.
International immunology 1989;1(2):141-50.
1988: C M Hawrylowicz; Emil R Unanue
Regulation of antigen-presentation-I. IFN-gamma induces antigen-presenting properties on B cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4083-8.
1988: Clifford V Harding; Francisco Leyva-Cobian; Emil R Unanue
Mechanisms of antigen processing.
Immunological reviews 1988;106():77-92.
1988: C T Weaver; C M Hawrylowicz; Emil R Unanue
T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8181-5.
1988: R C Fuhlbrigge; Kathleen C F Sheehan; Robert D Schreiber; D D Chaplin; Emil R Unanue
Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(8):2643-50.
1988: Francisco Leyva-Cobian; Emil R Unanue
Intracellular interference with antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(5):1445-50.
1988: R C Fuhlbrigge; S M Fine; Emil R Unanue; D D Chaplin
Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5649-53.
1988: K Deschryver-Kecskemeti; G J Bancroft; Gayle C Bosma; Melvin J Bosma; Emil R Unanue
Pathology of Listeria infection in murine severe combined immunodeficiency. A study by immunohistochemistry and electron microscopy.
Laboratory investigation; a journal of technical methods and pathology 1988;58(6):698-705.
1988: I F Luescher; P M Allen; Emil R Unanue
Binding of photoreactive lysozyme peptides to murine histocompatibility class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):871-4.
1987: G J Bancroft; Robert D Schreiber; Gayle C Bosma; Melvin J Bosma; Emil R Unanue
A T cell-independent mechanism of macrophage activation by interferon-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(4):1104-7.
1987: P M Allen; B P Babbitt; Emil R Unanue
T-cell recognition of lysozyme: the biochemical basis of presentation.
Immunological reviews 1987;98():171-87.
1987: R C Fuhlbrigge; D D Chaplin; J M Kiely; Emil R Unanue
Regulation of interleukin 1 gene expression by adherence and lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(11):3799-802.
1987: Emil R Unanue; C T Weaver; R C Fuhlbrigge; J M Kiely; D D Chaplin
Membrane IL-1: a key protein in antigen presentation.
Annales de l'Institut Pasteur. Immunology 1987;138(3):489-92.
1986: G J Bancroft; Melvin J Bosma; Gayle C Bosma; Emil R Unanue
Regulation of macrophage Ia expression in mice with severe combined immunodeficiency: induction of Ia expression by a T cell-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(1):4-9.