Willy Underberg

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Tempels F W Alexander; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
Design and applications of coupled SPE-CE.
Tempels F W Alexander; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
On-line coupling of SPE and CE-MS for peptide analysis.
Zacharis Constantinos K; Tempels F W Alexander; Theodoridis Georgios A; Voulgaropoulos Anastasios N; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
Coupling of sequential injection analysis and capillary electrophoresis - Laser-induced fluorescence via a valve interface for on-line derivatization and analysis of amino acids and peptides.

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2008: Tempels F W Alexander; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
Design and applications of coupled SPE-CE.
Electrophoresis 2008;29(1):108-28.
2007: Tempels F W Alexander; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
On-line coupling of SPE and CE-MS for peptide analysis.
Electrophoresis 2007;28(9):1319-26.
2006: Zacharis Constantinos K; Tempels F W Alexander; Theodoridis Georgios A; Voulgaropoulos Anastasios N; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
Coupling of sequential injection analysis and capillary electrophoresis - Laser-induced fluorescence via a valve interface for on-line derivatization and analysis of amino acids and peptides.
Journal of chromatography. A 2006;1132(1-2):297-303.
2006: Tempels F W Alexander; Wiese Gerard; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
On-line coupling of size exclusion chromatography and capillary electrophoresis via solid-phase extraction and a Tee-split interface.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;839(1-2):30-5.
2005: Stroink Thom; Ortiz Mireya Castillo; Bult Auke; Lingeman Henk; de Jong Gerhardus J; Underberg Willy J M
On-line multidimensional liquid chromatography and capillary electrophoresis systems for peptides and proteins.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;817(1):49-66.
2004: Tempels F W Alexander; Teeuwsen Jan; Kyriakou Ioannis K; Theodoridis Georgios; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
Chromatographic preconcentration coupled on-line to capillary electrophoresis via a tee-split interface.
Journal of chromatography. A 2004;1053(1-2):263-8.
2004: Tempels F W Alexander; Underberg Willy J M; Somsen Govert W; de Jong Gerhardus J
Chromatographic preconcentration coupled to capillary electrophoresis via an in-line injection valve.
Analytical chemistry 2004;76(15):4432-6.
2003: Stroink Thom; Schravendijk Pim; Wiese Gerard; Teeuwsen Jan; Lingeman Henk; Waterval Joop C M; Bult Auke; de Jong Gerhardus J; Underberg Willy J M
On-line coupling of size-exclusion chromatography and capillary zone electrophoresis via a reversed-phase C18 trapping column for the determination of peptides in biological samples.
Electrophoresis 2003;24(6):1126-34.
2003: Stroink Thom; Wiese Gerard; Teeuwsen Jan; Lingeman Henk; Waterval Joop C M; Bult Auke; de Jong Gerhardus J; Underberg Willy J M
On-line coupling of size exclusion and capillary zone electrophoresis via a reversed-phase C18 trapping column for the analysis of structurally related enkephalins in cerebrospinal fluid.
Electrophoresis 2003;24(5):897-903.
2002: Underberg Willy J M; Waterval Joop C M
Derivatization trends in capillary electrophoresis: an update.
Electrophoresis 2002;23(22-23):3922-33.
2002: Stroink Thom; Wiese Gerard; Teeuwsen Jan; Lingeman Henk; Waterval Joop C M; Bult Auke; de Jong Gerhardus J; Underberg Willy J M
On-line coupling of SEC and RP-LC for the determination of structurally related enkephalins in cerebrospinal fluid.
Journal of pharmaceutical and biomedical analysis 2002;30(4):1393-401.
2002: Vernooij E A A M; Kettenes-van den Bosch J J; Underberg W J M; Crommelin D J A
Chemical hydrolysis of DOTAP and DOPE in a liposomal environment.
Journal of controlled release : official journal of the Controlled Release Society 2002;79(1-3):299-303.
2002: Boone Carolien M; Manetto Giulia; Tagliaro Franco; Waterval Joop C M; Underberg Willy J M; Franke Jan-Piet; de Zeeuw Rokus A; Ensing Kees
Interlaboratory reproducibility of mobility parameters in capillary electrophoresis for substance identification in systematic toxicological analysis.
Electrophoresis 2002;23(1):67-73.
2001: Cadée J A; van Steenbergen M J; Versluis C; Heck A J; Underberg W J; den Otter W; Jiskoot W; Hennink W E
Oxidation of recombinant human interleukin-2 by potassium peroxodisulfate.
Pharmaceutical research 2001;18(10):1461-7.
2001: Waterval J C; Hommels G; Bestebreurtje P; Versluis C; Heck A J; Bult A; Lingeman H; Underberg W J
Capillary electrophoretic bioanalysis of therapeutically active peptides with UV and mass spectrometric detection after on-capillary preconcentration.
Electrophoresis 2001;22(13):2709-16.
2001: Waterval J C; Bestebreurtje P; Lingeman H; Versluis C; Heck A J; Bult A; Underberg W J
Robust and cost-effective capillary electrophoresis-mass spectrometry interfaces suitable for combination with on-line analyte preconcentration.
Electrophoresis 2001;22(13):2701-8.
2001: Stroink T; Paarlberg E; Waterval J C; Bult A; Underberg W J
On-line sample preconcentration in capillary electrophoresis, focused on the determination of proteins and peptides.
Electrophoresis 2001;22(12):2375-83.
2001: Waterval J C; Bloks J C; Sparidans R W; Beijnen J H; Rodriguez-Campos I M; Bult A; Lingeman H; Underberg W J
Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.
Journal of chromatography. B, Biomedical sciences and applications 2001;754(1):161-8.
2000: Waterval J C; Lingeman H; Bult A; Underberg W J
Derivatization trends in capillary electrophoresis.
Electrophoresis 2000;21(18):4029-45.
2000: Waterval J C; Hommels G; Teeuwsen J; Bult A; Lingeman H; Underberg W J
Quantitative analysis of pharmaceutically active peptides using on-capillary analyte preconcentration transient isotachophoresis.
Electrophoresis 2000;21(14):2851-8.
2000: Underberg W J; Hoitink M A; Reubsaet J L; Waterval J C
Separation and detection techniques for peptides and proteins in stability research and bioanalysis.
Journal of chromatography. B, Biomedical sciences and applications 2000;742(2):401-9.
2000: Hoitink M A; Beijnen J H; Bult A; Damen J M; van der Houwen O A; Kruijtzer J A; Tibben M M; Wiese G; Underberg W J
Degradation of azaglycinamido residues in model tripeptides derived from goserelin.
Journal of pharmaceutical sciences 2000;89(1):108-14.
1999: Waterval J C; Krabbe H; Teeuwsen J; Bult A; Lingeman H; Underberg W J
Comparison between transient isotachophoretic capillary zone electrophoresis and reversed-phase liquid chromatography for the determination of peptides in plasma.
Electrophoresis 1999;20(14):2909-16.
1999: Boone C M; Waterval J C; Lingeman H; Ensing K; Underberg W J
Capillary electrophoresis as a versatile tool for the bioanalysis of drugs--a review.
Journal of pharmaceutical and biomedical analysis 1999;20(6):831-63.
1999: Sluiter C; Kettenes-van den Bosch J J; Hop E; van der Houwen O A; Underberg W J; Bult A
Degradation study of the investigational anticancer drug clanfenur.
International journal of pharmaceutics 1999;185(2):227-35.
1999: Léon J; Reubsaet E; Beijnen J H; van Bennekom W P; Bult A; Hoekstra A J; Hop E; van Os P J; Teeuwsen J; Underberg W J
Reduction of Cys36-Cys42 and Cys64-Cys74 disulfide bonds in recombinant human granulocyte colony stimulating factor.
Journal of pharmaceutical and biomedical analysis 1999;19(6):837-45.
1999: Oussoren C; Magnani M; Fraternale A; Casabianca A; Chiarantini L; Ingebrigsten R; Underberg W J; Storm G
Liposomes as carriers of the antiretroviral agent dideoxycytidine-5'-triphosphate.
International journal of pharmaceutics 1999;180(2):261-70.
1999: Reubsaet J L; Beijnen J H; Belshof E H; Bouyakhrichan M; Bult A; Hop E; Kellekule Y; van Maanen R J; Teeuwsen J; Underberg W J
Qualitative and quantitative aspects of the degradation of several tripeptides derived from the antitumour peptide antagonist [Arg(6), D-Trp(7,9), MePhe(8)] substance P[6-11].
Journal of pharmaceutical and biomedical analysis 1999;19(3-4):277-84.
1998: Waterval J C; la Porte C J; van 't Hof R; Teeuwsen J; Bult A; Lingeman H; Underberg W J
Development and validation of transient isotachophoretic capillary zone electrophoresis for determination of peptides.
Electrophoresis 1998;19(18):3171-7.
1998: Reubsaet J L; Beijnen J H; Bult A; van Maanen R J; Marchal J A; Underberg W J
Analytical techniques used to study the degradation of proteins and peptides: physical instability.
Journal of pharmaceutical and biomedical analysis 1998;17(6-7):979-84.
1998: Reubsaet J L; Beijnen J H; Bult A; van Maanen R J; Marchal J A; Underberg W J
Analytical techniques used to study the degradation of proteins and peptides: chemical instability.
Journal of pharmaceutical and biomedical analysis 1998;17(6-7):955-78.
1998: Koppenhagen F J; Storm G; Underberg W J
Development of a routine analysis method for liposome encapsulated recombinant interleukin-2.
Journal of chromatography. B, Biomedical sciences and applications 1998;716(1-2):285-91.
1998: Hoitink M A; Beijnen J H; Boschma M U; Bult A; van der Houwen O A; Wiese G; Underberg W J
Degradation kinetics of three gonadorelin analogues: developing a method for calculating epimerization parameters.
Pharmaceutical research 1998;15(9):1449-55.
1998: Reubsaet J L; Beijnen J H; Bult A; Hop E; Scholten S D; Teeuwsen J; Underberg W J
Oxidation of recombinant methionyl human granulocyte colony stimulating factor.
Journal of pharmaceutical and biomedical analysis 1998;17(2):283-9.
1998: Kaijser G P; De Kraker J; Bult A; Underberg W J; Beijnen J H
Pharmacokinetics of ifosfamide and some metabolites in children.
Anticancer research 1998;18(3B):1941-9.
1998: Bardelmeijer H A; Lingeman H; de Ruiter C; Underberg W J
Derivatization in capillary electrophoresis.
Journal of chromatography. A 1998;807(1):3-26.
1997: Bardelmeijer H A; Waterval J C; Lingeman H; van't Hof R; Bult A; Underberg W J
Pre-, on- and post-column derivatization in capillary electrophoresis.
Electrophoresis 1997;18(12-13):2214-27.
1997: van Dijk-Wolthuis W N; van Steenbergen M J; Underberg W J; Hennink W E
Degradation kinetics of methacrylated dextrans in aqueous solution.
Journal of pharmaceutical sciences 1997;86(4):413-7.
1997: Kaijser G P; Ter Riet P G; de Kraker J; Bult A; Beijnen J H; Underberg W J
Determination of 4-hydroxyifosfamide in biological matrices by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis 1997;15(6):773-81.
1997: Jonkman-de Vries J D; Van den Bemt B J; ten Bokkel-Huinink W W; Underberg W J; Kettenes-van den Bosch J J; Henrar R E; Bult A; Beijnen J H
Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur.
PDA journal of pharmaceutical science and technology / PDA 1997;51(2):89-95.
1997: Kaijser G P; Beijnen J H; Bult A; Keizer H J; Underberg W J
Chromatographic analysis of the enantiomers of ifosfamide and some of its metabolites in plasma and urine.
Journal of chromatography. B, Biomedical sciences and applications 1997;690(1-2):131-8.
1996: Kaijser G P; Beijnen J H; Rozendom E; Bult A; Underberg W J
Analysis of ifosforamide mustard, the active metabolite of ifosfamide, in plasma.
Journal of chromatography. B, Biomedical applications 1996;686(2):249-55.
1996: Hoitink M A; Beijnen J H; Bult A; van der Houwen O A; Nijholt J; Underberg W J
Degradation kinetics of gonadorelin in aqueous solution.
Journal of pharmaceutical sciences 1996;85(10):1053-9.
1996: Kaijser G P; Keizer H J; Beijnen J H; Bult A; Underberg W J
Pharmacokinetics of ifosfamide, 2- and 3-dechloroethylifosfamide in plasma and urine of cancer patients treated with a 10-day continuous infusion of ifosfamide.
Anticancer research 1996;16(5B):3247-57.
1995: Reubsaet J L; Beijnen J H; Bult A; Hop E; Vermaas R; Kellekule Y; Kettenes-van den Bosch J J; Underberg W J
Structural identification of the degradation products of the antitumor peptide antagonist [Arg6,D-Trp7,9,MePhe8]substance P (6-11).
Analytical chemistry 1995;67(23):4431-6.
1995: Reubsaet J L; Beijnen J H; Bult A; van der Houwen O A; Teeuwsen J; Koster E H; Underberg W J
Degradation kinetics of antagonist [Arg6, D-Trp7,9, MePhe8]-substance P [6-11] in aqueous solutions.
Analytical biochemistry 1995;227(2):334-41.
1994: Reubsaet J L; Beijnen J H; Bult A; Teeuwsen J; Koster E H; Waterval J C; Underberg W J
Reversed-phase high-performance liquid chromatography and capillary electrophoresis in the stability study of the neuropeptide growth factor antagonist [Arg6,D-Trp7,9,MePhe8]-substance P (6-11): a comparative study.
Analytical biochemistry 1994;220(1):98-102.
1994: Burger D M; Meenhorst P L; Underberg W J; van der Heijde J F; Koks C H; Beijnen J H
Short-term, combined use of paracetamol and zidovudine does not alter the pharmacokinetics of either drug.
The Netherlands journal of medicine 1994;44(5):161-5.
1994: Kaijser G P; Beijnen J H; Bult A; Underberg W J
Ifosfamide metabolism and pharmacokinetics (review).
Anticancer research 1994;14(2A):517-31.
1993: Wafelman A R; Nortier Y L; Rosing H; Underberg W J; Maes R A; Beijnen J H
High-performance liquid chromatographic determination of m-iodobenzylguanidine in urine of cancer patients.
Journal of chromatography 1993;622(1):71-7.
1993: Knoester P D; Underberg W J; Beijnen J H
Clinical pharmacokinetics and pharmacodynamics of anticancer agents in pediatric patients (review).
Anticancer research 1993;13(5C):1795-808.
1993: Kaijser G P; Korst A; Beijnen J H; Bult A; Underberg W J
The analysis of ifosfamide and its metabolites (review).
Anticancer research 1993;13(5A):1311-24.
1993: Bekers O; Beijnen J H; Tank M J; Burger D M; Meenhorst P L; Lombarts A J; Underberg W J
2',3'-dideoxyinosine (ddI): its chemical stability and cyclodextrin complexation in aqueous media.
Journal of pharmaceutical and biomedical analysis 1993;11(6):489-93.
1993: Grit M; Zuidam N J; Underberg W J; Crommelin D J
Hydrolysis of partially saturated egg phosphatidylcholine in aqueous liposome dispersions and the effect of cholesterol incorporation on hydrolysis kinetics.
The Journal of pharmacy and pharmacology 1993;45(6):490-5.
1993: Kaijser G P; Beijnen J H; Jeunink E L; Bult A; Keizer H J; de Kraker J; Underberg W J
Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma.
Journal of chromatography 1993;614(2):253-9.
1993: Grit M; Underberg W J; Crommelin D J
Hydrolysis of saturated soybean phosphatidylcholine in aqueous liposome dispersions.
Journal of pharmaceutical sciences 1993;82(4):362-6.
1992: Kaijser G P; Beijnen J H; Bult A; Wiese G; de Kraker J; Keizer H J; Underberg W J
Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine.
Journal of chromatography 1992;583(2):175-82.
1992: Beijnen J H; van Gijn R; Challa E E; Kaijser G P; Underberg W J
Chemical stability of two sterile, parenteral formulations of cyclophosphamide (Endoxan) after reconstitution and dilution in commonly used infusion fluids.
Journal of parenteral science and technology : a publication of the Parenteral Drug Association 1992;46(4):111-6.
1992: Hodes T J; Underberg W J; Los G; Beijnen J H
Platinum antitumour agents: a review of (bio)analysis.
Pharmaceutisch weekblad. Scientific edition 1992;14(3):61-77.
1991: Kaijser G P; Beijnen J H; Bult A; Wiese G; de Kraker J; Underberg W J
Gas chromatographic determination of ifosfamide in microvolumes of urine and plasma.
Journal of chromatography 1991;571(1-2):121-31.
1991: Beijnen J H; Beijnen-Bandhoe A U; Dubbelman A C; van Gijn R; Underberg W J
Chemical and physical stability of etoposide and teniposide in commonly used infusion fluids.
Journal of parenteral science and technology : a publication of the Parenteral Drug Association 1991;45(2):108-12.
1991: Beijnen J H; Meenhorst P L; van Gijn R; Fromme M; Rosing H; Underberg W J
HPLC determination of doxorubicin, doxorubicinol and four aglycone metabolites in plasma of AIDS patients.
Journal of pharmaceutical and biomedical analysis 1991;9(10-12):995-1002.
1991: Beijnen J H; Meenhorst P L; van Gijn R; Hazelager W A; Koks C H; Underberg W J
Gas chromatographic analysis, with electron capture detection, of the antifungal drug fluconazole in microvolumes of human plasma.
Journal of pharmaceutical and biomedical analysis 1991;9(10-12):1173-5.
1991: Kaijser G P; Beijnen J H; Bult A; Hogeboom M H; Underberg W J
A systematic study on the chemical stability of ifosfamide.
Journal of pharmaceutical and biomedical analysis 1991;9(10-12):1061-7.
1991: Bekers O; Beijnen J H; Tank M J; Bult A; Underberg W J
Effect of cyclodextrins on the chemical stability of mitomycins in alkaline solution.
Journal of pharmaceutical and biomedical analysis 1991;9(10-12):1055-60.
1990: Kaijser G P; Underberg W J; Beijnen J H
The risks of handling cytotoxic drugs. II. Recommendations for working with cytotoxic drugs.
Pharmaceutisch weekblad. Scientific edition 1990;12(6):228-35.
1990: Kaijser G P; Underberg W J; Beijnen J H
The risks of handling cytotoxic drugs. I. Methods of testing exposure.
Pharmaceutisch weekblad. Scientific edition 1990;12(6):217-27.
1990: Beijnen J H; van Gijn R; Horenblas S; Underberg W J
Chemical stability of suramin in commonly used infusion fluids.
DICP : the annals of pharmacotherapy 1990;24(11):1056-8.
1990: Beijnen J H; van Gijn R; Underberg W J
Chemical stability of the antitumor drug mitomycin C in solutions for intravesical instillation.
Journal of parenteral science and technology : a publication of the Parenteral Drug Association 1990;44(6):332-5.
1990: Beijnen J H; van Gijn R; Underberg W J
Gas chromatographic analysis, with nitrogen detection, of tocainide in plasma.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):1101-3.
1990: Beijnen J H; Smith B R; Keijer W J; van Gijn R; ten Bokkel Huinink W W; Vlasveld L T; Rodenhuis S; Underberg W J
High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):789-94.
1990: Underberg W J; Goossen R M; Smith B R; Beijnen J H
Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):681-3.
1990: Bekers O; Beijnen J H; Otagiri M; Bult A; Underberg W J
Inclusion complexation of doxorubicin and daunorubicin with cyclodextrins.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):671-4.
1989: Underberg W J; Hofman G A; Lubbers S C; Bekers O; Ten Bokkel Huinink W W; Beijnen J H
Bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug LL-D49194 alpha 1.
Journal of pharmaceutical and biomedical analysis 1989;7(12):1791-7.
1988: Bekers O; Beijnen J H; Groot Bramel E H; Otagiri M; Underberg W J
Effect of cyclodextrins on anthracycline stability in acidic aqueous media.
Pharmaceutisch weekblad. Scientific edition 1988;10(5):207-12.
1988: van der Nat J M; Beijnen J H; Driebergen R J; Thart L A; van Dijk H; Underberg W J; Labadie R P
In vitro immunosuppressive activities of recently developed anthracycline cytostatics.
Anticancer research 1988;8(3):489-93.
1987: Underberg W J; Beijnen J H
Re-use of mitomycin C in the treatment of superficial tumours of the urinary bladder: an evaluation in view of its chemical stability.
Anticancer research 1987;7(4B):707-10.
1986: Beijnen J H; van der Houwen O A; Rosing H; Underberg W J
A systematic study on the chemical stability of mitomycin A and mitomycin B.
Chemical & pharmaceutical bulletin 1986;34(7):2900-13.
1986: Lingeman H; van Munster H A; Beynen J H; Underberg W J; Hulshoff A
High-performance liquid chromatographic analysis of basic compounds on non-modified silica gel and aluminium oxide with aqueous solvent mixtures.
Journal of chromatography 1986;352():261-74.
1986: Beijnen J H; Van der Nat J M; Labadie R P; Underberg W J
Decomposition of mitomycin and anthracycline cytostatics in cell culture media.
Anticancer research 1986;6(1):39-43.
1985: Beijnen J H; Rosing H; de Vries P A; Underberg W J
Stability of anthracycline antitumour agents in infusion fluids.
Journal of parenteral science and technology : a publication of the Parenteral Drug Association 1985;39(6):220-2.
1985: Beijnen J H; Wiese G; Underberg W J
Aspects of the chemical stability of doxorubicin and seven other anthracyclines in acidic solution.
Pharmaceutisch weekblad. Scientific edition 1985;7(3):109-16.
1983: Underberg W J; Lingeman H
Aspects of the chemical stability of mitomycin and porfiromycin in acidic solution.
Journal of pharmaceutical sciences 1983;72(5):549-53.
1983: Underberg W J; Lingeman H
Determination of pKa values of some prototropic functions in mitomycin and porfiromycin.
Journal of pharmaceutical sciences 1983;72(5):553-6.

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Willy Underberg

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