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Roger Unger

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Eric D Berglund; Roger H Unger
Role of fibroblast growth factor 21 in biology of glucagon.
May-Yun Wang; Xinxin Yu; Suzanne Strowig; Roger H Unger; GREGORY CLARK; Young Lee; S Kay McCorkle; Philip Raskin
Iatrogenic hyperinsulinemia in type 1 diabetes: its effect on atherogenic risk markers.
Young Lee; May-Yun Wang; Xinxin Yu; Eric D Berglund; Shawn C Burgess; Maureen J Charron; Xiaorong Fu; Roger H Unger
Metabolic manifestations of insulin deficiency do not occur without glucagon action.

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2013: Eric D Berglund; Roger H Unger
Role of fibroblast growth factor 21 in biology of glucagon.
Diabetes 2013;62(5):1376.
2013: May-Yun Wang; Xinxin Yu; Suzanne Strowig; Roger H Unger; GREGORY CLARK; Young Lee; S Kay McCorkle; Philip Raskin
Iatrogenic hyperinsulinemia in type 1 diabetes: its effect on atherogenic risk markers.
Journal of diabetes and its complications 2013;27(1):70-4.
2012: Young Lee; May-Yun Wang; Xinxin Yu; Eric D Berglund; Shawn C Burgess; Maureen J Charron; Xiaorong Fu; Roger H Unger
Metabolic manifestations of insulin deficiency do not occur without glucagon action.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):14972-6.
2011: Lijun Chen; Jacques Philippe; Roger H Unger
Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2011;17(5):819-25.
2010: Cuneyt Yilmaz; Priya Ravikumar; Dennis J Bellotto; Roger H Unger; Connie C W Hsia
Fatty diabetic lung: functional impairment in a model of metabolic syndrome.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;109(6):1913-9.
2010: Roger H Unger; Lelio Orci
Paracrinology of islets and the paracrinopathy of diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(37):16009-12.
2010: Roger H Unger; Philipp E Scherer
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.
Trends in endocrinology and metabolism: TEM 2010;21(6):345-52.
2010: May-Yun Wang; Lijun Chen; GREGORY CLARK; Young Lee; Robert D Stevens; Olga R Ilkayeva; Brett R Wenner; James R Bain; Maureen J Charron; Christopher B Newgard; Roger H Unger
Leptin therapy in insulin-deficient type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4813-9.
2010: David J Foster; Priya Ravikumar; Dennis J Bellotto; Roger H Unger; Connie C W Hsia
Fatty diabetic lung: altered alveolar structure and surfactant protein expression.
American journal of physiology. Lung cellular and molecular physiology 2010;298(3):L392-403.
2010: Roger H Unger; GREGORY CLARK; Philipp E Scherer; Lelio Orci
Lipid homeostasis, lipotoxicity and the metabolic syndrome.
Biochimica et biophysica acta 2010;1801(3):209-14.
2009: Christine M Kusminski; Shoba Shetty; Lelio Orci; Roger H Unger; Philipp E Scherer
Diabetes and apoptosis: lipotoxicity.
Apoptosis : an international journal on programmed cell death 2009;14(12):1484-95.
2008: Xinxin Yu; Byung-Hyun Park; May-Yun Wang; Zhao V Wang; Roger H Unger
Making insulin-deficient type 1 diabetic rodents thrive without insulin.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):14070-5.
2008: Roger H Unger
Noninvasive tracking of gene expression by reporter transgene imaging.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12641-2.
2008: May-Yun Wang; Paul Grayburn; Shuyuan Chen; Mariella Ravazzola; Lelio Orci; Roger H Unger
Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6139-44.
2008: Roger H Unger
Reinventing type 2 diabetes: pathogenesis, treatment, and prevention.
JAMA : the journal of the American Medical Association 2008;299(10):1185-7.
2007: Lidia S Szczepaniak; Ronald G Victor; Lelio Orci; Roger H Unger
Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America.
Circulation research 2007;101(8):759-67.
2007: Young Lee; Mariella Ravazzola; Byung-Hyun Park; Yuriy Bashmakov; Lelio Orci; Roger H Unger
Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin.
Diabetes 2007;56(9):2295-301.
2006: Byung-Hyun Park; May-Yun Wang; Young Lee; Xinxin Yu; Mariella Ravazzola; Lelio Orci; Roger H Unger
Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: implications for obesity treatment.
The Journal of biological chemistry 2006;281(52):40283-91.
2006: Young Lee; R Haris Naseem; Byung-Hyun Park; Daniel J Garry; James A Richardson; Jean E Schaffer; Roger H Unger
Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice.
Biochemical and biophysical research communications 2006;344(1):446-52.
2006: Jonathan M McGavock; Ronald G Victor; Roger H Unger; Lidia S Szczepaniak
Adiposity of the heart, revisited.
Annals of internal medicine 2006;144(7):517-24.
2006: Roger H Unger; Joel K Elmquist
Movin' on up: adipocytes become regulators of nutrient homeostasis.
Cell metabolism 2006;3(3):147-8.
2005: May-Yun Wang; Lelio Orci; Mariella Ravazzola; Roger H Unger
Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18011-6.
2005: Roger H Unger
Hyperleptinemia: protecting the heart from lipid overload.
Hypertension 2005;45(6):1031-4.
2005: May-Yun Wang; Roger H Unger
Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone.
American journal of physiology. Endocrinology and metabolism 2005;288(1):E216-21.
2004: Xinxin Yu; S McCorkle; M Wang; Young Lee; Jinping Li; A K Saha; Roger H Unger; N B Ruderman
Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.
Diabetologia 2004;47(11):2012-21.
2004: Byung-Hyun Park; Young Lee; Marlei Walton; Laurence Duplomb; Roger H Unger
Demonstration of reverse fatty acid transport from rat cardiomyocytes.
Journal of lipid research 2004;45(11):1992-9.
2004: Laurence Duplomb; Kiyosumi Takaishi; Byung-Hyun Park; Theo J Visser; Roger H Unger
Independence of hyperleptinemia-induced fat disappearance from thyroid hormone.
Biochemical and biophysical research communications 2004;323(1):49-51.
2004: Young Lee; R Haris Naseem; Laurence Duplomb; Byung-Hyun Park; Daniel J Garry; James A Richardson; Jean E Schaffer; Roger H Unger
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(37):13624-9.
2004: Kiyosumi Takaishi; Laurence Duplomb; May-Yun Wang; Jinping Li; Roger H Unger
Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7106-11.
2004: Roger H Unger
The hyperleptinemia of obesity-regulator of caloric surpluses.
Cell 2004;117(2):145-6.
2004: Lelio Orci; William S Cook; Mariella Ravazzola; May-Yun Wang; Byung-Hyun Park; Roberto Montesano; Roger H Unger
Rapid transformation of white adipocytes into fat-oxidizing machines.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2058-63.
2004: Laurence Duplomb; Young Lee; May-Yun Wang; Byung-Hyun Park; Kiyosumi Takaishi; Anil K Agarwal; Roger H Unger
Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone.
Biochemical and biophysical research communications 2004;313(3):594-9.
2003: Roger H Unger
Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome.
Endocrinology 2003;144(12):5159-65.
2003: Roger H Unger
Lipid overload and overflow: metabolic trauma and the metabolic syndrome.
Trends in endocrinology and metabolism: TEM 2003;14(9):398-403.
2003: Jinping Li; Kiyosumi Takaishi; William Cook; Sara Kay McCorkle; Roger H Unger
Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9476-81.
2003: Roger H Unger
The physiology of cellular liporegulation.
Annual review of physiology 2003;65():333-47.
2002: Roger H Unger; Lelio Orci
Lipoapoptosis: its mechanism and its diseases.
Biochimica et biophysica acta 2002;1585(2-3):202-12.
2002: Tetsuya Kakuma; Young Lee; Roger H Unger
Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase.
Biochemical and biophysical research communications 2002;297(5):1259-63.
2002: Young Lee; Xinxin Yu; F Gonzales; David J Mangelsdorf; May-Yun Wang; C Richardson; L A Witters; Roger H Unger
PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11848-53.
2002: Jinping Li; Xinxin Yu; Wentong Pan; Roger H Unger
Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1334-41.
2002: W S Cook; Roger H Unger
Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity.
Developmental cell 2002;2(4):385-7.
2002: Roger H Unger
Lipotoxic diseases.
Annual review of medicine 2002;53():319-36.
2001: Young Lee; May-Yun Wang; Tetsuya Kakuma; ZW Wang; Evelyn E Babcock; K McCorkle; M Higa; YT Zhou; Roger H Unger
Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia.
The Journal of biological chemistry 2001;276(8):5629-35.
2001: Roger H Unger; YT Zhou
Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.
Diabetes 2001;50 Suppl 1():S118-21.
2001: Roger H Unger; Lelio Orci
Diseases of liporegulation: new perspective on obesity and related disorders.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):312-21.
2001: ZW Wang; W T Pan; Young Lee; Tetsuya Kakuma; YT Zhou; Roger H Unger
The role of leptin resistance in the lipid abnormalities of aging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):108-114.
2000: Tetsuya Kakuma; ZW Wang; W Pan; Roger H Unger; YT Zhou
Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression.
Endocrinology 2000;141(12):4576-82.
2000: Roger H Unger; Lelio Orci
Lipotoxic diseases of nonadipose tissues in obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 4():S28-32.
2000: Z w Wang; YT Zhou; Tetsuya Kakuma; Young Lee; SP Kalra; Pushpa S Kalra; W Pan; Roger H Unger
Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling.
Biochemical and biophysical research communications 2000;277(1):20-6.
2000: Tetsuya Kakuma; Young Lee; M Higa; Z w Wang; W Pan; Iichiro Shimomura; Roger H Unger
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8536-41.
2000: Ralph V Shohet; Shuyuan Chen; YT Zhou; Z w Wang; Robert S Meidell; Roger H Unger; Paul A Grayburn
Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium.
Circulation 2000;101(22):2554-6.
2000: YT Zhou; Paul A Grayburn; A Karim; Michio Shimabukuro; M Higa; Danielle Baetens; Lelio Orci; Roger H Unger
Lipotoxic heart disease in obese rats: implications for human obesity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1784-9.
1999: M Higa; YT Zhou; Mariella Ravazzola; Danielle Baetens; Lelio Orci; Roger H Unger
Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11513-8.
1999: ZW Wang; YT Zhou; Tetsuya Kakuma; Young Lee; M Higa; SP Kalra; M G Dube; Pushpa S Kalra; Roger H Unger
Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10373-8.
1999: ZW Wang; YT Zhou; Young Lee; M Higa; SP Kalra; Roger H Unger
Hyperleptinemia depletes fat from denervated fat tissue.
Biochemical and biophysical research communications 1999;260(3):653-7.
1999: May-Yun Wang; Young Lee; Roger H Unger
Novel form of lipolysis induced by leptin.
The Journal of biological chemistry 1999;274(25):17541-4.
1999: May-Yun Wang; Michio Shimabukuro; Young Lee; KY Trinh; J L Chen; Christopher B Newgard; Roger H Unger
Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.
Diabetes 1999;48(5):1020-5.
1999: YT Zhou; ZW Wang; M Higa; Christopher B Newgard; Roger H Unger
Reversing adipocyte differentiation: implications for treatment of obesity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2391-5.
1999: Roger H Unger; YT Zhou; Lelio Orci
Regulation of fatty acid homeostasis in cells: novel role of leptin.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2327-32.
1998: Michio Shimabukuro; M Higa; YT Zhou; May-Yun Wang; Christopher B Newgard; Roger H Unger
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression.
The Journal of biological chemistry 1998;273(49):32487-90.
1998: YT Zhou; Michio Shimabukuro; Young Lee; K Koyama; M Higa; T Ferguson; Roger H Unger
Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes.
Diabetes 1998;47(12):1904-8.
1998: May-Yun Wang; K Koyama; Michio Shimabukuro; David J Mangelsdorf; Christopher B Newgard; Roger H Unger
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11921-6.
1998: K Koyama; Michio Shimabukuro; Guoxun Chen; May-Yun Wang; Young Lee; Pushpa S Kalra; M G Dube; SP Kalra; Christopher B Newgard; Roger H Unger
Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors.
The Journal of clinical investigation 1998;102(4):728-33.
1998: Michio Shimabukuro; May-Yun Wang; YT Zhou; Christopher B Newgard; Roger H Unger
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9558-61.
1998: YT Zhou; Michio Shimabukuro; May-Yun Wang; Young Lee; M Higa; J L Milburn; Christopher B Newgard; Roger H Unger
Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8898-903.
1998: Michio Shimabukuro; YT Zhou; Moshe Levi; Roger H Unger
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2498-502.
1998: Michio Shimabukuro; YT Zhou; Young Lee; Roger H Unger
Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats.
The Journal of biological chemistry 1998;273(6):3547-50.
1998: May-Yun Wang; K Koyama; Michio Shimabukuro; Christopher B Newgard; Roger H Unger
OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):714-8.
1997: YT Zhou; Michio Shimabukuro; Young Lee; K Koyama; F Trieu; Roger H Unger
Leptin normalizes the impaired response of proinsulin mRNA to long chain fatty acids in heterozygous Zucker diabetic fatty rats.
The Journal of biological chemistry 1997;272(41):25648-51.
1997: K Koyama; G Chen; Y Lee; Roger H Unger
Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity.
The American journal of physiology 1997;273(4 Pt 1):E708-13.
1997: Michio Shimabukuro; K Koyama; Young Lee; Roger H Unger
Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.
The Journal of clinical investigation 1997;100(7):1750-4.
1997: Roger H Unger
How obesity causes diabetes in Zucker diabetic fatty rats.
Trends in endocrinology and metabolism: TEM 1997;8(7):276-82.
1997: Michio Shimabukuro; YT Zhou; Young Lee; Roger H Unger
Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats.
Biochemical and biophysical research communications 1997;237(2):359-61.
1997: K Koyama; G Chen; M Y Wang; Young Lee; Michio Shimabukuro; C B Newgard; Roger H Unger
beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy.
Diabetes 1997;46(8):1276-80.
1997: Michio Shimabukuro; M Ohneda; Young Lee; Roger H Unger
Role of nitric oxide in obesity-induced beta cell disease.
The Journal of clinical investigation 1997;100(2):290-5.
1997: YT Zhou; Michio Shimabukuro; K Koyama; Young Lee; May-Yun Wang; F Trieu; Christopher B Newgard; Roger H Unger
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6386-90.
1997: Michio Shimabukuro; K Koyama; Guoxun Chen; May-Yun Wang; F Trieu; Young Lee; Christopher B Newgard; Roger H Unger
Direct antidiabetic effect of leptin through triglyceride depletion of tissues.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4637-41.
1997: Young Lee; H Hirose; YT Zhou; Victoria Esser; J Denis McGarry; Roger H Unger
Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.
Diabetes 1997;46(3):408-13.
1996: Guoxun Chen; K Koyama; X Yuan; Young Lee; YT Zhou; R O'Doherty; Christopher B Newgard; Roger H Unger
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14795-9.
1996: May-Yun Wang; YT Zhou; Christopher B Newgard; Roger H Unger
A novel leptin receptor isoform in rat.
FEBS letters 1996;392(2):87-90.
1996: H Hirose; Y H Lee; L R Inman; Y Nagasawa; J H Johnson; Roger H Unger
Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes.
The Journal of biological chemistry 1996;271(10):5633-7.
1995: Roger H Unger
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.
Diabetes 1995;44(8):863-70.
1995: M Ohneda; L R Inman; Roger H Unger
Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence.
Diabetologia 1995;38(2):173-9.
1995: J L Milburn; H Hirose; Y H Lee; Y Nagasawa; A Ogawa; M Ohneda; H BeltrandelRio; Christopher B Newgard; J H Johnson; Roger H Unger
Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids.
The Journal of biological chemistry 1995;270(3):1295-9.
1994: M Ohneda; J H Johnson; Y H Lee; Y Nagasawa; Roger H Unger
Post-GLUT-2 defects in beta-cells of non-insulin-dependent diabetic obese rats.
The American journal of physiology 1994;267(6 Pt 1):E968-74.
1994: Young Lee; H Hirose; M Ohneda; J H Johnson; J Denis McGarry; Roger H Unger
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10878-82.
1994: S Chen; A Ogawa; M Ohneda; Roger H Unger; Daniel W Foster; J Denis McGarry
More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling.
Diabetes 1994;43(7):878-83.
1993: M Ohneda; J H Johnson; L R Inman; Roger H Unger
GLUT-2 function in glucose-unresponsive beta cells of dexamethasone-induced diabetes in rats.
The Journal of clinical investigation 1993;92(4):1950-6.
1993: J L Milburn; M Ohneda; J H Johnson; Roger H Unger
Beta-cell GLUT-2 loss and non-insulin-dependent diabetes mellitus: current status of the hypothesis.
Diabetes/metabolism reviews 1993;9(3):231-6.
1993: T R Pieber; Daniel Stein; A Ogawa; T Alam; M Ohneda; K McCorkle; L Chen; J Denis McGarry; Roger H Unger
Amylin-insulin relationships in insulin resistance with and without diabetic hyperglycemia.
The American journal of physiology 1993;265(3 Pt 1):E446-53.
1993: M Ohneda; J H Johnson; L R Inman; L Chen; K Suzuki; Y Goto; T Alam; M Ravazzola; L Orci; Roger H Unger
GLUT2 expression and function in beta-cells of GK rats with NIDDM. Dissociation between reductions in glucose transport and glucose-stimulated insulin secretion.
Diabetes 1993;42(7):1065-72.
1993: L R Inman; C T McAllister; L Chen; S Hughes; Christopher B Newgard; J R Kettman; Roger H Unger; J H Johnson
Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1281-4.
1992: Abhimanyu Garg; Scott M Grundy; Roger H Unger
Comparison of effects of high and low carbohydrate diets on plasma lipoproteins and insulin sensitivity in patients with mild NIDDM.
Diabetes 1992;41(10):1278-85.
1992: A Ogawa; J H Johnson; M Ohneda; C T McAllister; L Inman; T Alam; Roger H Unger
Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes.
The Journal of clinical investigation 1992;90(2):497-504.
1992: T Alam; L Chen; A Ogawa; J D Leffert; Roger H Unger; Kenneth Luskey
Coordinate regulation of amylin and insulin expression in response to hypoglycemia and fasting.
Diabetes 1992;41(4):508-14.
1992: Roger H Unger
[Role of the glut 2 transporters in the pathogenesis of type II diabetes].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1992;():53-62.
1992: L Chen; M C Appel; T Alam; C Miyaura; A Sestak; J O'Neil; Roger H Unger; Christopher B Newgard
Factors regulating islet regeneration in the post-insulinoma NEDH rat.
Advances in experimental medicine and biology 1992;321():71-80; discussion 81-4.
1991: Roger H Unger
Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells.
Science (New York, N.Y.) 1991;251(4998):1200-5.
1991: C Miyaura; L Chen; M Appel; T Alam; L Inman; S D Hughes; J L Milburn; Roger H Unger; Christopher B Newgard
Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass.
Molecular endocrinology (Baltimore, Md.) 1991;5(2):226-34.
1990: L Orci; Mariella Ravazzola; D Baetens; L Inman; Mylene Amherdt; R G Peterson; Christopher B Newgard; J H Johnson; Roger H Unger
Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9953-7.
1990: L Orci; Roger H Unger; Mariella Ravazzola; A Ogawa; I Komiya; D Baetens; Harvey Lodish; B Thorens
Reduced beta-cell glucose transporter in new onset diabetic BB rats.
The Journal of clinical investigation 1990;86(5):1615-22.
1990: J H Johnson; A Ogawa; L Chen; L Orci; Christopher B Newgard; T Alam; Roger H Unger
Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes.
Science (New York, N.Y.) 1990;250(4980):546-9.
1990: I Komiya; D Baetens; M Kuwajima; L Orci; Roger H Unger
Compensatory capabilities of islets of BB/Wor rats exposed to sustained hyperglycemia.
Metabolism: clinical and experimental 1990;39(6):614-8.
1990: L Chen; T Alam; J H Johnson; S Hughes; Christopher B Newgard; Roger H Unger
Regulation of beta-cell glucose transporter gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(11):4088-92.
1990: J H Johnson; Bill P Crider; K McCorkle; M Alford; Roger H Unger
Inhibition of glucose transport into rat islet cells by immunoglobulins from patients with new-onset insulin-dependent diabetes mellitus.
The New England journal of medicine 1990;322(10):653-9.
1990: A Ogawa; V Harris; S K McCorkle; Roger H Unger; Kenneth Luskey
Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment.
The Journal of clinical investigation 1990;85(3):973-6.
1989: L Chen; I Komiya; L Inman; J O'Neil; M Appel; T Alam; Roger H Unger
Effects of hypoglycemia and prolonged fasting on insulin and glucagon gene expression. Studies with in situ hybridization.
The Journal of clinical investigation 1989;84(2):711-4.
1989: L Chen; I Komiya; L Inman; K McCorkle; T Alam; Roger H Unger
Molecular and cellular responses of islets during perturbations of glucose homeostasis determined by in situ hybridization histochemistry.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1367-71.
1988: Abhimanyu Garg; Andrea Bonanome; Scott M Grundy; Z J Zhang; Roger H Unger
Comparison of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin-dependent diabetes mellitus.
The New England journal of medicine 1988;319(13):829-34.
1988: T Imamura; M Koffler; J Harold Helderman; D Prince; R Thirlby; L Inman; Roger H Unger
Severe diabetes induced in subtotally depancreatized dogs by sustained hyperglycemia.
Diabetes 1988;37(5):600-9.
1988: I Komiya; Roger H Unger
Absence of glucopenic inhibition of the insulin response to arginine at the onset of diabetes in BB/W rats.
Diabetologia 1988;31(4):225-7.