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Helmut Unruh

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Caveolin 1

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Saeid Ghavami; Thomas Klonisch; Mark M Mutawe; Dedmer Schaafsma; Helmut Unruh; Behzad Yeganeh; Andrew J Halayko
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
Reinoud Gosens; Sophie T Bos; Gordon Dueck; William T Gerthoffer; Herman Meurs; Mark M Mutawe; Dedmer Schaafsma; Gerald L Stelmack; Helmut Unruh; Johan Zaagsma; Andrew J Halayko
Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells.
Dedmer Schaafsma; Gordon Dueck; Saeid Ghavami; Andrea Kroeker; Mark M Mutawe; Kristin Hauff; Fred Y Xu; Karol D McNeill; Helmut Unruh; Grant M Hatch; Andrew J Halayko
The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle.

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All Publications

2012: Saeid Ghavami; Thomas Klonisch; Mark M Mutawe; Dedmer Schaafsma; Helmut Unruh; Behzad Yeganeh; Andrew J Halayko
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2012;302(4):L420-8.
2011: Reinoud Gosens; Sophie T Bos; Gordon Dueck; William T Gerthoffer; Herman Meurs; Mark M Mutawe; Dedmer Schaafsma; Gerald L Stelmack; Helmut Unruh; Johan Zaagsma; Andrew J Halayko
Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells.
Journal of cellular and molecular medicine 2011;15(11):2430-42.
2011: Dedmer Schaafsma; Gordon Dueck; Saeid Ghavami; Andrea Kroeker; Mark M Mutawe; Kristin Hauff; Fred Y Xu; Karol D McNeill; Helmut Unruh; Grant M Hatch; Andrew J Halayko
The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle.
American journal of respiratory cell and molecular biology 2011;44(3):394-403.
2011: Dedmer Schaafsma; Helmut Unruh; Jamila Chakir; Saeid Ghavami; Eric Jacques; Michel Laviolette; Karol D McNeill; Mark M Mutawe; Andrew J Halayko
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.
Respiratory research 2011;12():113.
2011: Saeid Ghavami; Mark M Mutawe; Pawan Sharma; Behzad Yeganeh; Karol D McNeill; Thomas Klonisch; Helmut Unruh; Hessam H Kashani; Dedmer Schaafsma; Marek Los; Andrew J Halayko
Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53.
PloS one 2011;6(1):e16523.
2010: Pawan Sharma; Saeid Ghavami; Gerald L Stelmack; Karol D McNeill; Mark M Mutawe; Thomas Klonisch; Helmut Unruh; Andrew J Halayko
beta-Dystroglycan binds caveolin-1 in smooth muscle: a functional role in caveolae distribution and Ca2+ release.
Journal of cell science 2010;123(Pt 18):3061-70.
2008: Pawan Sharma; Thai Tran; Gerald L Stelmack; Karol D McNeill; Reinoud Gosens; Mark M Mutawe; Helmut Unruh; William T Gerthoffer; Andrew J Halayko
Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation.
American journal of physiology. Lung cellular and molecular physiology 2008;294(1):L57-68.
2007: Reinoud Gosens; Gerald L Stelmack; Gordon Dueck; Mark M Mutawe; Martha Hinton; Karol D McNeill; Angela Paulson; Shyamala Dakshinamurti; William T Gerthoffer; James A Thliveris; Helmut Unruh; Johan Zaagsma; Andrew J Halayko
Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2007;293(6):L1406-18.
2007: Thai Tran; Karen Ens-Blackie; Edward S Rector; Gerald L Stelmack; Karol D McNeill; Guido Tarone; William T Gerthoffer; Helmut Unruh; Andrew J Halayko
Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes.
American journal of respiratory cell and molecular biology 2007;37(6):668-80.
2007: Reinoud Gosens; Gordon Dueck; Edward S Rector; Raquel O Nunes; William T Gerthoffer; Helmut Unruh; Johan Zaagsma; Herman Meurs; Andrew J Halayko
Cooperative regulation of GSK-3 by muscarinic and PDGF receptors is associated with airway myocyte proliferation.
American journal of physiology. Lung cellular and molecular physiology 2007;293(5):L1348-58.
2007: Keqin Zhang; Lianyu Shan; Muhammad Shahidur Rahman; Helmut Unruh; Andrew J Halayko; Abdelilah Soussi Gounni
Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease.
American journal of physiology. Lung cellular and molecular physiology 2007;293(2):L375-82.
2007: Reinoud Gosens; Gordon Dueck; William T Gerthoffer; Helmut Unruh; Johan Zaagsma; Herman Meurs; Andrew J Halayko
p42/p44 MAP kinase activation is localized to caveolae-free membrane domains in airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2007;292(5):L1163-72.
2007: Stéphane Dragon; Muhammad Shahidur Rahman; Jie Yang; Helmut Unruh; Andrew J Halayko; Abdelilah Soussi Gounni
IL-17 enhances IL-1beta-mediated CXCL-8 release from human airway smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2007;292(4):L1023-9.
2006: Reinoud Gosens; Gerald L Stelmack; Gordon Dueck; Karol D McNeill; Akira Yamasaki; William T Gerthoffer; Helmut Unruh; Abdelilah Soussi Gounni; Johan Zaagsma; Andrew J Halayko
Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L523-34.
2006: Smita Pakhale; Helmut Unruh; Lawrence Tan; Sat Sharma
Has mediastinoscopy still a role in suspected stage I sarcoidosis?
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 2006;23(1):66-9.
2006: Thai Tran; Karol D McNeill; William T Gerthoffer; Helmut Unruh; Andrew J Halayko
Endogenous laminin is required for human airway smooth muscle cell maturation.
Respiratory research 2006;7():117.
2005: Muhammad Shahidur Rahman; Jie Yang; Lianyu Shan; Helmut Unruh; Xi Yang; Andrew J Halayko; Abdelilah Soussi Gounni
IL-17R activation of human airway smooth muscle cells induces CXCL-8 production via a transcriptional-dependent mechanism.
Clinical immunology (Orlando, Fla.) 2005;115(3):268-76.
2005: Andrew J Halayko; Gerald L Stelmack; Akira Yamasaki; Karol D McNeill; Helmut Unruh; Edward S Rector
Distribution of phenotypically disparate myocyte subpopulations in airway smooth muscle.
Canadian journal of physiology and pharmacology 2005;83(1):104-16.
2003: Newman L Stephens; Weilong Li; He Jiang; Helmut Unruh; Xuefei Ma
The biophysics of asthmatic airway smooth muscle.
Respiratory physiology & neurobiology 2003;137(2-3):125-40.
2002: Xuefei Ma; Zhaoqin Cheng; Hong Kong; Ying Wang; Helmut Unruh; Newman L Stephens; Michel Laviolette
Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects.
American journal of physiology. Lung cellular and molecular physiology 2002;283(6):L1181-9.
2000: A L Tan; Helmut Unruh; Steven N Mink
Lung volume reduction surgery for the treatment of severe emphysema: a study in a single Canadian institution.
Canadian journal of surgery. Journal canadien de chirurgie 2000;43(5):369-76.
1999: Carla Chrusch; S Sharma; Helmut Unruh; Edgar Bautista; Krika Duke; A Becker; Wayne Kepron; Steven N Mink
Histamine H3 receptor blockade improves cardiac function in canine anaphylaxis.
American journal of respiratory and critical care medicine 1999;160(4):1142-9.
1999: Steven N Mink; A Becker; S Sharma; Helmut Unruh; Krika Duke; Wayne Kepron
Role of autacoids in cardiovascular colapse in anaphylactic shock in anaesthetized dogs.
Cardiovascular research 1999;43(1):173-82.
1998: Steven N Mink; C Bands; A Becker; J Elkin; S Sharma; Helmut Unruh; Wayne Kepron
Effect of bolus epinephrine on systemic hemodynamics in canine anaphylactic shock.
Cardiovascular research 1998;40(3):546-56.
1998: Steven N Mink; A Becker; Helmut Unruh; Wayne Kepron
Effects of anaphylaxis mediators on partitioned pulmonary vascular resistance during ragweed shock in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;84(3):782-90.
1996: C M Baron; S E Kowalski; R Greengrass; T A Horan; Helmut Unruh; C L Baron
Epinephrine decreases postoperative requirements for continuous thoracic epidural fentanyl infusions.
Anesthesia and analgesia 1996;82(4):760-5.
1996: D Lieberman; J Littleford; T Horan; Helmut Unruh
Placement of left double-lumen endobronchial tubes with or without a stylet.
Canadian journal of anaesthesia = Journal canadien d'anesthésie 1996;43(3):238-42.
1996: Nasreen Khalil; R N O'Connor; K C Flanders; Helmut Unruh
TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.
American journal of respiratory cell and molecular biology 1996;14(2):131-8.
1995: Helmut Unruh
Lung preservation and lung injury.
Chest surgery clinics of North America 1995;5(1):91-106.
1994: D F Vretenar; J D Urschel; J C Parrott; Helmut Unruh
Cardiopulmonary bypass resuscitation for accidental hypothermia.
The Annals of thoracic surgery 1994;58(3):895-8.
1994: A Gomez; Helmut Unruh; Steven N Mink
Left ventricular systolic performance is depressed in chronic pulmonary emphysema in dogs.
The American journal of physiology 1994;267(1 Pt 2):H232-47.
1993: R Bigsby; R Greengrass; Helmut Unruh
Diagnostic algorithm for acute superior vena caval obstruction (SVCO).
The Journal of cardiovascular surgery 1993;34(4):347-50.
1993: Helmut Unruh
Pulmonary endothelial cell function after modified Eurocollins solution infusion.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1993;12(4):700-5.
1993: C W Sawchuk; B Ong; Helmut Unruh; T A Horan; R Greengrass
Thoracic versus lumbar epidural fentanyl for postthoracotomy pain.
The Annals of thoracic surgery 1993;55(6):1472-6.
1993: A Gomez; Helmut Unruh; Steven N Mink
Altered left ventricular chamber stiffness and isovolumic relaxation in dogs with chronic pulmonary hypertension caused by emphysema.
Circulation 1993;87(1):247-60.
1992: Helmut Unruh
Vascular and interstitial effect of University of Wisconsin solution on canine lung.
The Annals of thoracic surgery 1992;54(6):1168-71.
1992: J D Urschel; T A Horan; Helmut Unruh
Plasma cell granuloma of the lung.
The Journal of thoracic and cardiovascular surgery 1992;104(4):870-5.
1992: J D Urschel; J C Parrott; T A Horan; Helmut Unruh
Pneumothorax complicating cardiac surgery.
The Journal of cardiovascular surgery 1992;33(4):492-5.
1992: P McDonald; Merv Letts; G Sutherland; Helmut Unruh
Aneurysmal bone cyst of the upper thoracic spine. An operative approach through a manubrial sternotomy.
Clinical orthopaedics and related research 1992;(279):127-32.
1991: Helmut Unruh; R Wang; Deepak Bose; Steven N Mink
Does pentobarbital anesthesia depress left ventricular contractility in dogs?
The American journal of physiology 1991;261(3 Pt 2):H700-6.
1991: Nasreen Khalil; R N O'Connor; Helmut Unruh; P W Warren; K C Flanders; A Kemp; O H Bereznay; Arnold H Greenberg
Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis.
American journal of respiratory cell and molecular biology 1991;5(2):155-62.
1991: E Correa; Steven N Mink; Helmut Unruh; Wayne Kepron
Left ventricular contractility is depressed in IgE-mediated anaphylactic shock in dogs.
The American journal of physiology 1991;260(3 Pt 2):H744-51.
1991: E L MacIntosh; J C Parrott; Helmut Unruh
Fistulas between the aorta and tracheobronchial tree.
The Annals of thoracic surgery 1991;51(3):515-9.
1991: Nasreen Khalil; R O'Connor; Helmut Unruh; Peter Warren; A Kemp; A Greenberg
Enhanced expression and immunohistochemical distribution of transforming growth factor-beta in idiopathic pulmonary fibrosis.
Chest 1991;99(3 Suppl):65S-66S.
1991: F Baldwin; A Hovey; T McEwen; R O'Connor; Helmut Unruh; D H Bowden
Surface to nuclear distances in human bronchial epithelium: relationships to penetration by Rn daughters.
Health physics 1991;60(2):155-62.
1990: A Gomez; R Wang; Helmut Unruh; R Bruce Light; Deepak Bose; T Chau; E Correa; Steven N Mink
hemofiltration reverses left ventricular dysfunction during sepsis in dogs.
Anesthesiology 1990;73(4):671-85.
1990: I Ali; Helmut Unruh
Management of empyema thoracis.
The Annals of thoracic surgery 1990;50(3):355-9.
1990: Helmut Unruh; M Hoppensack; L Oppenheimer
Vascular properties of canine lungs perfused with Eurocollins solution and prostacyclin.
The Annals of thoracic surgery 1990;49(2):292-8.
1989: R P Guzman; R Wightman; Esther Ravinsky; Helmut Unruh
Primary malignant melanoma of the esophagus with diffuse melanocytic atypia and melanoma in situ.
American journal of clinical pathology 1989;92(6):802-4.
1988: R T Onotera; Helmut Unruh
Closure of a post-pneumonectomy bronchopleural fistula with fibrin sealant (Tisseel).
Thorax 1988;43(12):1015-6.
1985: Steven N Mink; Helmut Unruh; L Oppenheimer
Vascular and interstitial mechanics in canine pulmonary emphysema.
Journal of applied physiology (Bethesda, Md. : 1985) 1985;59(6):1704-15.
1984: Helmut Unruh; H S Goldberg; L Oppenheimer
Pulmonary interstitial compartments and tissue resistance to fluid flux.
Journal of applied physiology: respiratory, environmental and exercise physiology 1984;57(5):1512-9.
1984: J Malo; H Goldberg; R Graham; Helmut Unruh; C Skoog
Effect of hypoxic hypoxia on systemic vasculature.
Journal of applied physiology: respiratory, environmental and exercise physiology 1984;56(5):1403-10.
1983: J Ali; Helmut Unruh; C Skoog; H S Goldberg
The effect of lung edema on pulmonary vasoactivity of furosemide.
The Journal of surgical research 1983;35(5):383-90.
1983: L Oppenheimer; Helmut Unruh; C Skoog; H S Goldberg
Transvascular fluid flux measured from intravascular water concentration changes.
Journal of applied physiology: respiratory, environmental and exercise physiology 1983;54(1):64-72.