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Cecilia Unson

Research Profile

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Lada Krilov; Norman H Lee; Teruo Miyazaki; Amy Nguyen; Cecilia G Unson; Russell Williams; Susan Ceryak; Bernard Bouscarel
Dual mode of glucagon receptor internalization: role of PKCα, GRKs and β-arrestins.
Pallavi Sachdev; Laxmi Manohar Tirunagari; Dennis Kappei; Cecilia G Unson
Monitoring glucagon and glucagon antagonist-mediated internalization: a useful approach to study glucagon receptor pharmacology.
Lada Krilov; Amy Nguyen; Teruo Miyazaki; Cecilia G Unson; Bernard Bouscarel
Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton.

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2011: Lada Krilov; Norman H Lee; Teruo Miyazaki; Amy Nguyen; Cecilia G Unson; Russell Williams; Susan Ceryak; Bernard Bouscarel
Dual mode of glucagon receptor internalization: role of PKCα, GRKs and β-arrestins.
Experimental cell research 2011;317(20):2981-94.
2009: Pallavi Sachdev; Laxmi Manohar Tirunagari; Dennis Kappei; Cecilia G Unson
Monitoring glucagon and glucagon antagonist-mediated internalization: a useful approach to study glucagon receptor pharmacology.
Advances in experimental medicine and biology 2009;611():325-6.
2008: Lada Krilov; Amy Nguyen; Teruo Miyazaki; Cecilia G Unson; Bernard Bouscarel
Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton.
American journal of physiology. Cell physiology 2008;295(5):C1230-7.
2008: Cecilia G Unson
Merrifield laboratory: last member standing.
Biopolymers 2008;90(3):243-4.
2008: Cecilia G Unson
Expression of glucagon receptors in tetracycline-inducible HEK293S GnT1- stable cell lines: an approach toward purification of receptor protein for structural studies.
Biopolymers 2008;90(3):287-96.
2007: Alexandre Charbonneau; Cecilia G Unson; Jean-Marc Lavoie
High-fat diet-induced hepatic steatosis reduces glucagon receptor content in rat hepatocytes: potential interaction with acute exercise.
The Journal of physiology 2007;579(Pt 1):255-67.
2006: Clemence MERLEN; Sylvie Fabrega; Bernard Desbuquois; Cecilia G Unson; François Authier
Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver.
FEBS letters 2006;580(24):5697-704.
2005: Andy J Fischer; Ghezal Omar; Nathaniel A Walton; Thomas A Verrill; Cecilia G Unson
Glucagon-expressing neurons within the retina regulate the proliferation of neural progenitors in the circumferential marginal zone of the avian eye.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(44):10157-66.
2002: Cecilia G Unson; Cui-Rong Wu; Youwei Jiang; Barney Yoo; Connie Cheung; Thomas P Sakmar; RB Merrifield
Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling.
Biochemistry 2002;41(39):11795-803.
2002: Anne-Marie Sapse; Robert Rothchild; Duli C Jain; Cecilia G Unson
The role of salt bridge formation in glucagon: an experimental and theoretical study of glucagon analogs and peptide fragments of glucagon.
Molecular medicine (Cambridge, Mass.) 2002;8(5):251-62.
2002: Cecilia G Unson
Molecular determinants of glucagon receptor signaling.
Biopolymers 2002;66(4):218-35.
2001: Y Jiang; AM Cypess; E D Muse; Cui-Rong Wu; Cecilia G Unson; RB Merrifield; Thomas P Sakmar
Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10102-7.
2000: Cecilia G Unson; Cui-Rong Wu; Thomas P Sakmar; RB Merrifield
Selective stabilization of the high affinity binding conformation of glucagon receptor by the long splice variant of Galpha(s).
The Journal of biological chemistry 2000;275(28):21631-8.
1999: AM Cypess; Cecilia G Unson; Cui-Rong Wu; Thomas P Sakmar
Two cytoplasmic loops of the glucagon receptor are required to elevate cAMP or intracellular calcium.
The Journal of biological chemistry 1999;274(27):19455-64.
1998: Cecilia G Unson; Cui-Rong Wu; C P Cheung; RB Merrifield
Positively charged residues at positions 12, 17, and 18 of glucagon ensure maximum biological potency.
The Journal of biological chemistry 1998;273(17):10308-12.
1996: Cecilia G Unson; A M Cypess; Cui-Rong Wu; Paul K Goldsmith; RB Merrifield; Thomas P Sakmar
Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):310-5.
1995: Cecilia G Unson; A M Cypess; H N Kim; Paul K Goldsmith; C J Carruthers; RB Merrifield; Thomas P Sakmar
Characterization of deletion and truncation mutants of the rat glucagon receptor. Seven transmembrane segments are necessary for receptor transport to the plasma membrane and glucagon binding.
The Journal of biological chemistry 1995;270(46):27720-7.
1994: C J Carruthers; Cecilia G Unson; H N Kim; Thomas P Sakmar
Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding.
The Journal of biological chemistry 1994;269(46):29321-8.
1994: Cecilia G Unson; Cui-Rong Wu; RB Merrifield
Roles of aspartic acid 15 and 21 in glucagon action: receptor anchor and surrogates for aspartic acid 9.
Biochemistry 1994;33(22):6884-7.
1994: Cecilia G Unson; Cui-Rong Wu; K J Fitzpatrick; RB Merrifield
Multiple-site replacement analogs of glucagon. A molecular basis for antagonist design.
The Journal of biological chemistry 1994;269(17):12548-51.
1994: Cecilia G Unson; RB Merrifield
Identification of an essential serine residue in glucagon: implication for an active site triad.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(2):454-8.
1993: Cecilia G Unson; D Macdonald; RB Merrifield
The role of histidine-1 in glucagon action.
Archives of biochemistry and biophysics 1993;300(2):747-50.
1991: A Shenker; P Goldsmith; Cecilia G Unson; Allen Spiegel
The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family.
The Journal of biological chemistry 1991;266(14):9309-13.
1991: William F Simonds; J E Butrynski; N Gautam; Cecilia G Unson; Allen Spiegel
G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.
The Journal of biological chemistry 1991;266(9):5363-6.
1991: Cecilia G Unson; D Macdonald; K Ray; T L Durrah; RB Merrifield
Position 9 replacement analogs of glucagon uncouple biological activity and receptor binding.
The Journal of biological chemistry 1991;266(5):2763-6.
1991: A Shenker; P Goldsmith; Cecilia G Unson; Allen Spiegel
The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family.
Transactions of the Association of American Physicians 1991;104():11-20.
1990: C Carr; C Loney; Cecilia G Unson; J Knowler; Graeme Milligan
Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gs).
European journal of pharmacology 1990;188(4-5):203-9.
1990: Allen Spiegel; William F Simonds; Teresa L Z Jones; Paul K Goldsmith; Cecilia G Unson
Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment.
Biochemical Society symposium 1990;56():61-9.
1990: Allen Spiegel; William F Simonds; Teresa L Z Jones; Paul K Goldsmith; Cecilia G Unson
Antibodies against synthetic peptides as probes of G protein structure and function.
Society of General Physiologists series 1990;45():185-95.
1989: Cecilia G Unson; E M Gurzenda; RB Merrifield
Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist.
Peptides 1989;10(6):1171-7.
1989: William F Simonds; Paul K Goldsmith; J Codina; Cecilia G Unson; Allen Spiegel
Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7809-13.
1989: Graeme Milligan; Cecilia G Unson; Michael J O Wakelam
Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs).
The Biochemical journal 1989;262(2):643-9.
1989: Graeme Milligan; Cecilia G Unson
Persistent activation of the alpha subunit of Gs promotes its removal from the plasma membrane.
The Biochemical journal 1989;260(3):837-41.
1989: William F Simonds; Paul K Goldsmith; C J Woodard; Cecilia G Unson; Allen Spiegel
Receptor and effector interactions of Gs. Functional studies with antibodies to the alpha s carboxyl-terminal decapeptide.
FEBS letters 1989;249(2):189-94.
1989: Graeme Milligan; Z Tanfin; O Goureau; Cecilia G Unson; Simone Harbon
Identification of both Gi2 and a novel, immunologically distinct, form of Go in rat myometrial membranes.
FEBS letters 1989;244(2):411-6.
1989: Cecilia G Unson; E M Gurzenda; K Iwasa; RB Merrifield
Glucagon antagonists: contribution to binding and activity of the amino-terminal sequence 1-5, position 12, and the putative alpha-helical segment 19-27.
The Journal of biological chemistry 1989;264(2):789-94.
1988: R Cortés; Tomas Hökfelt; Martin Schalling; M Goldstein; P Goldsmith; Allen Spiegel; Cecilia G Unson; J Walsh
Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9351-5.
1988: Ian Mullaney; A I Magee; Cecilia G Unson; Graeme Milligan
Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.
The Biochemical journal 1988;256(2):649-56.
1988: P Goldsmith; P S Backlund; K Rossiter; A Carter; G Milligan; Cecilia G Unson; Allen Spiegel
Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go.
Biochemistry 1988;27(18):7085-90.
1988: Graeme Milligan; Ian Mullaney; Cecilia G Unson; L Marshall; Allen Spiegel; H McArdle
GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells.
The Biochemical journal 1988;254(2):391-6.
1988: F R McKenzie; Ian Mullaney; Cecilia G Unson; Allen Spiegel; Graeme Milligan
The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins.
Biochemical Society transactions 1988;16(4):434-7.
1988: Richard A Cerione; S Kroll; R Rajaram; Cecilia G Unson; P Goldsmith; Allen Spiegel
An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function.
The Journal of biological chemistry 1988;263(19):9345-52.
1988: P Goldsmith; K Rossiter; A Carter; William F Simonds; Cecilia G Unson; R Vinitsky; Allen Spiegel
Identification of the GTP-binding protein encoded by Gi3 complementary DNA.
The Journal of biological chemistry 1988;263(14):6476-9.
1988: H McArdle; Ian Mullaney; A Magee; Cecilia G Unson; Graeme Milligan
GTP analogues cause release of the alpha subunit of the GTP binding protein, GO, from the plasma membrane of NG108-15 cells.
Biochemical and biophysical research communications 1988;152(1):243-51.
1988: P S Backlund; R R Aksamit; Cecilia G Unson; P Goldsmith; Allen Spiegel; G Milligan
Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line.
Biochemistry 1988;27(6):2040-6.
1988: R Collu; C Bouvier; G Lagacé; Cecilia G Unson; G Milligan; P Goldsmith; Allen Spiegel
Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors.
Endocrinology 1988;122(3):1176-8.
1988: F R McKenzie; E C Kelly; Cecilia G Unson; Allen Spiegel; Graeme Milligan
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
The Biochemical journal 1988;249(3):653-9.
1987: B Eide; P Gierschik; G Milligan; Ian Mullaney; Cecilia G Unson; P Goldsmith; Allen Spiegel
GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini.
Biochemical and biophysical research communications 1987;148(3):1398-405.
1987: P Goldsmith; P Gierschik; G Milligan; Cecilia G Unson; R Vinitsky; H L Malech; Allen Spiegel
Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.
The Journal of biological chemistry 1987;262(30):14683-8.
1987: Graeme Milligan; Allen Spiegel; Cecilia G Unson; E D Saggerson
Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins.
The Biochemical journal 1987;247(1):223-7.
1987: Cecilia G Unson; David Andreu; E M Gurzenda; RB Merrifield
Synthetic peptide antagonists of glucagon.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4083-7.
1987: S E Senogles; J L Benovic; N Amlaiky; Cecilia G Unson; G Milligan; R Vinitsky; Allen Spiegel; Marc G Caron
The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.
The Journal of biological chemistry 1987;262(10):4860-7.
1987: H Ogawa; Tomoharu Gomi; M M Mueckler; Motoji Fujioka; P S Backlund; R R Aksamit; Cecilia G Unson; G L Cantoni
Amino acid sequence of S-adenosyl-L-homocysteine hydrolase from rat liver as derived from the cDNA sequence.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(3):719-23.
1986: G de la Haba; S Agostini; A Bozzi; A Merta; Cecilia G Unson; G L Cantoni
S-adenosylhomocysteinase: mechanism of reversible and irreversible inactivation by ATP, cAMP, and 2'-deoxyadenosine.
Biochemistry 1986;25(25):8337-42.
1986: J Falloon; H Malech; G Milligan; Cecilia G Unson; R Kahn; P Goldsmith; Allen Spiegel
Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides.
FEBS letters 1986;209(2):352-6.