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Brad Upham

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TOP 3
Brad L Upham
Role of integrative signaling through gap junctions in toxicology.
James E Trosko; Brad L Upham
A paradigm shift is required for the risk assessment of potential human health after exposure to low level chemical exposures: a response to the toxicity testing in the 21st century report.
Alla L Alpatova; Wenqian Shan; Pavel Babica; Brad L Upham; Adam R Rogensues; Susan J Masten; Edward Drown; Amar K Mohanty; Evangelyn C Alocilja; Volodymyr V Tarabara
Single-walled carbon nanotubes dispersed in aqueous media via non-covalent functionalization: effect of dispersant on the stability, cytotoxicity, and epigenetic toxicity of nanotube suspensions.

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All Publications

2011: Brad L Upham
Role of integrative signaling through gap junctions in toxicology.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2011;Chapter 2():Unit2.18.
2010: James E Trosko; Brad L Upham
A paradigm shift is required for the risk assessment of potential human health after exposure to low level chemical exposures: a response to the toxicity testing in the 21st century report.
International journal of toxicology 2010;29(4):344-57.
2010: Alla L Alpatova; Wenqian Shan; Pavel Babica; Brad L Upham; Adam R Rogensues; Susan J Masten; Edward Drown; Amar K Mohanty; Evangelyn C Alocilja; Volodymyr V Tarabara
Single-walled carbon nanotubes dispersed in aqueous media via non-covalent functionalization: effect of dispersant on the stability, cytotoxicity, and epigenetic toxicity of nanotube suspensions.
Water research 2010;44(2):505-20.
2009: Yasushi Nakamura; Akari Kominami; Yoshiyuki Tsujimoto; Yuko Nakayama; Tsukasa Kitahashi; Sonoko Yoshimoto; Asuka Kubo; Shinpei Watanabe; Minami Kageyama; Meiko Yokoyama; Yasuhiro Kido; Yukiko Kobayashi; Masashi Kuwahata; Chia-Cheng Chang; Brad L Upham; James E Trosko; Eun Young Park; Kenji Sato
Actin and Vimentin proteins with N-terminal deletion detected in tumor-bearing rat livers induced by intraportal-vein injection of Ha-ras-transfected rat liver cells.
International journal of cancer. Journal international du cancer 2009;124(11):2512-9.
2009: Brad L Upham; Joon-Suk Park; Pavel Babica; Iva Sovadinova; Alisa M Rummel; James E Trosko; Akihiko Hirose; Ryuichi Hasegawa; Jun Kanno; Kimie Sai
Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems.
Environmental health perspectives 2009;117(4):545-51.
2008: Yasushi Nakamura; Yuko Nakayama; Hitomi Ando; Atsuo Tanaka; T Matsuo; S Okamoto; Brad L Upham; Chia-Cheng Chang; James E Trosko; Eun Young Park; Kenji Sato
3-Methylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cells.
Journal of agricultural and food chemistry 2008;56(9):2977-84.
2008: Brad L Upham; Ludek Bláha; Pavel Babica; Joon-Suk Park; Iva Sovadinova; Charles Pudrith; Alisa M Rummel; Liliane M Weis; Kimie Sai; Patricia K Tithof; Miodrag Guzvić; Jan Vondrácek; Miroslav Machala; James E Trosko
Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C.
Cancer science 2008;99(4):696-705.
2007: Jan Vondrácek; Lenka Švihálková-Šindlerová; Katerina Pencíková; Sona Marvanová; Pavel Krcmár; Miroslav Ciganek; Jirí Neca; James E Trosko; Brad L Upham; Alois Kozubík; Miroslav Machala
Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines.
Environmental toxicology and chemistry / SETAC 2007;26(11):2308-16.
2007: Mei-Hui Tai; Brad L Upham; L Karl Olson; Ming Tsao; Donald N Reed; James E Trosko
Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells.
International journal of cancer. Journal international du cancer 2007;120(9):1855-62.
2007: Brad L Upham; Miodrag Guzvić; Jacob Scott; Joseph M Carbone; Ludek Blaha; Chad Coe; Lan Lan Li; Alisa M Rummel; James E Trosko
Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrol.
Nutrition and cancer 2007;57(1):38-47.
2005: James E Trosko; Chia-Cheng Chang; Brad L Upham; Mei-Hui Tai
The role of human adult stem cells and cell-cell communication in cancer chemoprevention and chemotherapy strategies.
Mutation research 2005;591(1-2):187-97.
2005: Rita Loch-Caruso; Brad L Upham; Craig Harris; James E Trosko
Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):417-26.
2005: James E Trosko; Chia-Cheng Chang; Brad L Upham; Mei-Hui Tai
Low-dose ionizing radiation: induction of differential intracellular signalling possibly affecting intercellular communication.
Radiation and environmental biophysics 2005;44(1):3-9.
2005: Rita Loch-Caruso; Brad L Upham; Craig Harris; James E Trosko
Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):694-702.
2005: James E Trosko; Brad L Upham
The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment.
Mutagenesis 2005;20(2):81-92.
2005: Yasushi Nakamura; Chia-Cheng Chang; Toshio Mori; Kenji Sato; Kozo Ohtsuki; Brad L Upham; James E Trosko
Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.
Carcinogenesis 2005;26(3):665-71.
2005: Yasushi Nakamura; Noriko Yoshikawa; Ikumi Hiroki; Kenji Sato; Kozo Ohtsuki; Chia-Cheng Chang; Brad L Upham; James E Trosko
Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cells.
Nutrition and cancer 2005;51(2):218-25.
2004: James E Trosko; Chia-Cheng Chang; Brad L Upham; Mei-Hui Tai
Ignored hallmarks of carcinogenesis: stem cells and cell-cell communication.
Annals of the New York Academy of Sciences 2004;1028():192-201.
2004: Yasushi Nakamura; James E Trosko; Chia-Cheng Chang; Brad L Upham
Psyllium extracts decreased neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver oval cell line.
Cancer letters 2004;203(1):13-24.
2003: Miroslav Machala; Ludek Bláha; Jan Vondrácek; James E Trosko; Jacob Scott; Brad L Upham
Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action.
Toxicological sciences : an official journal of the Society of Toxicology 2003;76(1):102-11.
2003: Brad L Upham; Junji Suzuki; Gang Chen; Yurong Wang; Laura R McCabe; Chia-Cheng Chang; Vladimir A Krutovskikh; Hiroshi Yamasaki; James E Trosko
Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant-negative connexin 43.
Molecular carcinogenesis 2003;37(4):192-201.
2003: Brad L Upham; Alisa M Rummel; Joseph M Carbone; James E Trosko; Yanli Ouyang; Robert B Crawford; Norbert E Kaminski
Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line.
International journal of cancer. Journal international du cancer 2003;104(1):12-8.
2003: Brad L Upham; Tyler R Koski; Alisa M Rummel; Melinda R Wilson; Anelia Horvath; James E Trosko
Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis.
Cancer letters 2003;191(1):27-34.
2002: Wenyue Hu; Paul D Jones; Brad L Upham; James E Trosko; Christopher Lau; John P Giesy
Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(2):429-36.
2002: Anelia D Horvath; Brad L Upham; Varban S Ganev; James E Trosko
Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line.
Toxicon : official journal of the International Society on Toxinology 2002;40(3):273-82.
2002: Ludek Bláha; Petra Kapplová; Jan Vondrácek; Brad L Upham; Miroslav Machala
Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(1):43-51.
2001: Brad L Upham; James G Wagner
Toxicant-induced oxidative stress in cancer.
Toxicological sciences : an official journal of the Society of Toxicology 2001;64(1):1-3.
2001: Susan J Masten; M Tian; Brad L Upham; James E Trosko
Effect of selected pesticides and their ozonation by-products on gap junctional intercellular communication using rat liver epithelial cell lines.
Chemosphere 2001;44(3):457-65.
2000: G Chen; Brad L Upham; W Sun; C C Chang; Edward J Rothwell; K M Chen; H Yamasaki; James E Trosko
Effect of electromagnetic field exposure on chemically induced differentiation of friend erythroleukemia cells.
Environmental health perspectives 2000;108(10):967-72.
2000: James E Trosko; Chia-Cheng Chang; M R Wilson; Brad L Upham; T Hayashi; M Wade
Gap junctions and the regulation of cellular functions of stem cells during development and differentiation.
Methods (San Diego, Calif.) 2000;20(2):245-64.
2000: J Suzuki; Hye-Kyung Na; Brad L Upham; Chia-Cheng Chang; James E Trosko
Lambda-carrageenan-induced inhibition of gap-junctional intercellular communication in rat liver epithelial cells.
Nutrition and cancer 2000;36(1):122-8.
1999: Alisa M Rummel; James E Trosko; Melinda R Wilson; Brad L Upham
Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity.
Toxicological sciences : an official journal of the Society of Toxicology 1999;49(2):232-40.
1998: James E Trosko; C C Chang; Brad L Upham; M Wilson
Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication.
Toxicology letters 1998;102-103():71-8.
1998: Brad L Upham; ND Deocampo; B Wurl; James E Trosko
Inhibition of gap junctional intercellular communication by perfluorinated fatty acids is dependent on the chain length of the fluorinated tail.
International journal of cancer. Journal international du cancer 1998;78(4):491-5.
1998: Brad L Upham; L M Weis; James E Trosko
Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship.
Environmental health perspectives 1998;106 Suppl 4():975-81.
1998: L M Weis; Alisa M Rummel; Susan J Masten; James E Trosko; Brad L Upham
Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication.
Environmental health perspectives 1998;106(1):17-22.
1997: Brad L Upham; KS Kang; H Y Cho; James E Trosko
Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells.
Carcinogenesis 1997;18(1):37-42.
1996: Brad L Upham; L M Weis; Alisa M Rummel; S J Masten; James E Trosko
The effects of anthracene and methylated anthracenes on gap junctional intercellular communication in rat liver epithelial cells.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;34(2):260-4.
1996: L S Schnabelrauch; Marcia J Kieliszewski; Brad L Upham; H Alizedeh; D T Lamport
Isolation of pl 4.6 extensin peroxidase from tomato cell suspension cultures and identification of Val-Tyr-Lys as putative intermolecular cross-link site.
The Plant journal : for cell and molecular biology 1996;9(4):477-89.
1994: Brad L Upham; S J Masten; B R Lockwood; James E Trosko
Nongenotoxic effects of polycyclic aromatic hydrocarbons and their oxygenation by-products on the intercellular communication of rat liver epithelial cells.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;23(3):470-5.