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Neil Upton

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Andrew G Foley; Alison Prendergast; Claire Barry; Darren Scully; Neil Upton; Andrew D Medhurst; Ciaran M Regan
H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms.
Andrew G Foley; Warren D Hirst; Helen C Gallagher; Claire Barry; James Hagan; Neil Upton; Frank S Walsh; A Jackie Hunter; Ciaran M Regan
The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.
Kathryn R Starr; Gary W Price; Jeannette M Watson; Peter J Atkinson; Roberto Arban; Sergio Melotto; Lee A Dawson; James Hagan; Neil Upton; Mark S Duxon
SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.

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2009: Andrew G Foley; Alison Prendergast; Claire Barry; Darren Scully; Neil Upton; Andrew D Medhurst; Ciaran M Regan
H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(12):2585-600.
2008: Andrew G Foley; Warren D Hirst; Helen C Gallagher; Claire Barry; James Hagan; Neil Upton; Frank S Walsh; A Jackie Hunter; Ciaran M Regan
The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.
Neuropharmacology 2008;54(8):1166-74.
2007: Kathryn R Starr; Gary W Price; Jeannette M Watson; Peter J Atkinson; Roberto Arban; Sergio Melotto; Lee A Dawson; James Hagan; Neil Upton; Mark S Duxon
SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(10):2163-72.
2007: leann quinn; Marion J Perren; Kim T Brackenborough; Peter L Woodhams; Martin Vidgeon-Hart; Helen Chapman; Menelas Pangalos; Neil Upton; David J Virley
A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl.
Journal of neuroscience methods 2007;164(1):43-9.
2007: Andrew D Medhurst; Michael A Briggs; Gordon Bruton; Andy Robert Calver; Iain P Chessell; Barry Crook; John B Davis; Robert P Davis; Andrew G Foley; Teresa Heslop; Warren D Hirst; Stephen J Medhurst; Sandrine Ociepka; Alison Ray; Ciaran M Regan; Becky Sargent; Joanne Schogger; Tania O Stean; Brenda K Trail; Neil Upton; Trevor White; Barry Orlek; David M Wilson
Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.
Biochemical pharmacology 2007;73(8):1182-94.
2007: Perdita L Pugh; Jill C Richardson; Simon T Bate; Neil Upton; David Sunter
Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease.
Behavioural brain research 2007;178(1):18-28.
2007: Perdita L Pugh; Martin Vidgeon-Hart; Tracey E Ashmeade; Ainsley A Culbert; Zoe Seymour; Marion J Perren; Flora Joyce; Simon T Bate; Anna Babin; David J Virley; Jill C Richardson; Neil Upton; David Sunter
Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.
Journal of neuroinflammation 2007;4():8.
2006: Warren D Hirst; Tania O Stean; Derek C Rogers; David Sunter; Perdita L Pugh; Stephen F Moss; Steven M Bromidge; Graham Riley; Douglas R Smith; Sarah Bartlett; Christian A Heidbreder; Alan R Atkins; laurent lacroix; Lee A Dawson; Andrew G Foley; Ciaran M Regan; Neil Upton
SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.
European journal of pharmacology 2006;553(1-3):109-19.
2006: leann quinn; Tania O Stean; Helen Chapman; Matthew Brown; Martin Vidgeon-Hart; Neil Upton; Andrew Billinton; David J Virley
Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration.
Journal of neuroscience methods 2006;156(1-2):218-27.
2005: Mahmood Ahmed; Michael A Briggs; Steven M Bromidge; Tania Buck; Lorraine Campbell; Nigel J Deeks; Ashley Garner; Laurie Gordon; Dieter W Hamprecht; Vicky Holland; Christopher N Johnson; Andrew D Medhurst; Darren J Mitchell; Stephen F Moss; Jenifer Powles; Jon T Seal; Tania O Stean; Geoffrey Stemp; Mervyn Thompson; Brenda K Trail; Neil Upton; Kim Y Winborn; David R Witty
Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(21):4867-71.
2005: Tom D Heightman; Laramie M Gaster; Sarah L Pardoe; Jean-Pierre Pilleux; Michael S Hadley; Derek N Middlemiss; Gary W Price; Claire Roberts; Claire M Scott; Jeannette M Watson; Laurie J Gordon; Vicky Holland; Jenifer Powles; Graham J Riley; Tania O Stean; Brenda K Trail; Neil Upton; Nigel E Austin; Andrew Ayrton; Tanya Coleman; Leanne Cutler
8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: potent, selective, orally bioavailable 5-HT1 receptor ligands.
Bioorganic & medicinal chemistry letters 2005;15(19):4370-4.
2005: Y Ishii; John E Blundell; Jason C G Halford; Neil Upton; R Porter; A Johns; Robert John Rodgers
Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S.
Behavioural brain research 2005;160(1):11-24.
2005: Tania O Stean; Alan R Atkins; Christian A Heidbreder; leann quinn; Brenda K Trail; Neil Upton
Postsynaptic 5-HT1B receptors modulate electroshock-induced generalised seizures in rats.
British journal of pharmacology 2005;144(5):628-35.
2005: Y Ishii; John E Blundell; Jason C G Halford; Neil Upton; R Porter; A Johns; Phillip Jeffrey; Scott G Summerfield; Robert John Rodgers
Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867.
Behavioural brain research 2005;157(2):331-41.
2005: leann quinn; Robert Grundy; Colin A Campbell; Sarah Collier; Amanda Lawman; Tania O Stean; Andrew Billinton; Andrew A Parsons; Neil Upton; Mark S Duxon; Elaine A Irving
A novel behavioural registration system LABORAS and the social interaction paradigm detect long-term functional deficits following middle cerebral artery occlusion in the rat.
Brain research 2005;1031(1):118-24.
2004: Perdita L Pugh; Sharlin F Ahmed; Martin I Smith; Neil Upton; A Jackie Hunter
A behavioural characterisation of the FVB/N mouse strain.
Behavioural brain research 2004;155(2):283-9.
2004: Y Ishii; John E Blundell; Jason C G Halford; Neil Upton; R Porter; A Johns; Robert John Rodgers
Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats.
Physiology & behavior 2004;81(1):129-40.
2004: Andrew G Foley; Keith J Murphy; Warren D Hirst; Helen C Gallagher; James Hagan; Neil Upton; Frank S Walsh; Ciaran M Regan
The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(1):93-100.
2003: Paola Petrillo; Ornella Angelici; Sharon Bingham; Giovanna Ficalora; Martine Josette Garnier; paola francesca zaratin; Giuseppe Petrone; Ottorino Pozzi; Massimo Sbacchi; Tania O Stean; Neil Upton; Giulio Dondio; Mark A Scheideler
Evidence for a selective role of the delta-opioid agonist [8R-(4bS*,8aalpha,8abeta, 12bbeta)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline hydrochloride (SB-235863) in blocking hyperalgesia associated with inflammatory and neuropathic pain responses.
The Journal of pharmacology and experimental therapeutics 2003;307(3):1079-89.
2003: leann quinn; Tania O Stean; Brenda K Trail; Mark S Duxon; Sharon C Stratton; Andrew Billinton; Neil Upton
LABORAS: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour.
Journal of neuroscience methods 2003;130(1):83-92.
2003: Steve M Harrison; Alex J Harper; Julie Hawkins; Graham Duddy; Evelyn Grau; Perdita L Pugh; Panida H Winter; Claire S Shilliam; Zoë A Hughes; Lee A Dawson; M Isabel Gonzalez; Neil Upton; Menelas Pangalos; Colin Dingwall
BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.
Molecular and cellular neurosciences 2003;24(3):646-55.
2003: Nigel E Austin; Michael S Hadley; John D Harling; Frank P Harrington; Gregor Macdonald; Darren J Mitchell; Graham J Riley; Tania O Stean; Geoffrey Stemp; Sharon C Stratton; Mervyn Thompson; Neil Upton
The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents.
Bioorganic & medicinal chemistry letters 2003;13(10):1627-9.
2003: Martin I Smith; DC Piper; Mark S Duxon; Neil Upton
Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat.
Neuroscience letters 2003;341(3):256-8.
2003: Neil Upton; Sharon Stratton
Recent developments from genetic mouse models of seizures.
Current opinion in pharmacology 2003;3(1):19-26.
2002: Elaine A Irving; David C Harrison; A J Babbs; A C Mayes; Colin A Campbell; A Jackie Hunter; Neil Upton; Andrew A Parsons
Increased cortical expression of the orexin-1 receptor following permanent middle cerebral artery occlusion in the rat.
Neuroscience letters 2002;324(1):53-6.
2002: Tania O Stean; Warren D Hirst; David R Thomas; Gary W Price; Derek Rogers; Graham Riley; Steven M Bromidge; Halina T Serafinowska; Douglas R Smith; Sarah Bartlett; Nigel J Deeks; Mark S Duxon; Neil Upton
Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist.
Pharmacology, biochemistry, and behavior 2002;71(4):645-54.
2002: Martin I Smith; DC Piper; Mark S Duxon; Neil Upton
Effect of SB-243213, a selective 5-HT(2C) receptor antagonist, on the rat sleep profile: a comparison to paroxetine.
Pharmacology, biochemistry, and behavior 2002;71(4):599-605.
2001: H M Prosser; Catherine H Gill; Warren D Hirst; Evelyn Grau; M Robbins; Andy Robert Calver; Ellen M Soffin; C E Farmer; Christophe Lanneau; J Gray; E Schenck; B S Warmerdam; C Clapham; Charlie Reavill; Derek C Rogers; Tania O Stean; Neil Upton; K Humphreys; Andrew Randall; M Geppert; Ceri H Davies; Menelas Pangalos
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice.
Molecular and cellular neurosciences 2001;17(6):1059-70.
2001: Jackie Cilia; DC Piper; Neil Upton; James Hagan
Clozapine enhances breakpoint in common marmosets responding on a progressive ratio schedule.
Psychopharmacology 2001;155(2):135-43.
2001: Sharon Bingham; Philip T Davey; A J Babbs; Elaine A Irving; MJ Sammons; M Wyles; Phillip Jeffrey; Leanne Cutler; I Riba; A Johns; Rod A Porter; Neil Upton; A Jackie Hunter; Andrew A Parsons
Orexin-A, an hypothalamic peptide with analgesic properties.
Pain 2001;92(1-2):81-90.
2001: Robert John Rodgers; Jason C G Halford; Ricardo Luiz Nunes-de-Souza; Azair Canto-de-Souza; DC Piper; Jonathan R S Arch; Neil Upton; Rod A Porter; A Johns; John E Blundell
SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats.
The European journal of neuroscience 2001;13(7):1444-52.
2001: Simon Read; Warren D Hirst; Neil Upton; Andrew A Parsons
Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan.
Brain research 2001;891(1-2):69-77.
2001: Andrew Billinton; VH Baird; M Thom; John S Duncan; Neil Upton; Norman G Bowery
GABA(B(1)) mRNA expression in hippocampal sclerosis associated with human temporal lobe epilepsy.
Brain research. Molecular brain research 2001;86(1-2):84-9.
2001: Declan N C Jones; Jane E Gartlon; F Parker; SG Taylor; Carol Routledge; P Hemmati; Richard Munton; Tracey E Ashmeade; Jonathan P Hatcher; A Johns; Rod A Porter; James Hagan; A Jackie Hunter; Neil Upton
Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.
Psychopharmacology 2001;153(2):210-8.
2001: Mark S Duxon; J Stretton; Kathryn R Starr; Declan N C Jones; Vicky Holland; Graham Riley; Jeffrey C Jerman; Stephen J Brough; Darren Smart; A Johns; W Chan; Rod A Porter; Neil Upton
Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement.
Psychopharmacology 2001;153(2):203-9.
2001: Andrew Billinton; VH Baird; M Thom; John S Duncan; Neil Upton; Norman G Bowery
GABA(B) receptor autoradiography in hippocampal sclerosis associated with human temporal lobe epilepsy.
British journal of pharmacology 2001;132(2):475-80.
2000: Andrew Billinton; Tania O Stean; Norman G Bowery; Neil Upton
GABA(B(1)) splice variant mRNAs are differentially affected by electroshock induced seizure in rats.
Neuroreport 2000;11(17):3817-22.
2000: WN Chan; Michael S Hadley; John D Harling; Hugh J Herdon; Barry Orlek; Graham J Riley; R E Stead; Tania O Stean; Mervyn Thompson; Neil Upton; Robert W Ward
Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides.
Bioorganic & medicinal chemistry 2000;8(8):2085-94.
2000: Mark S Duxon; Kathryn R Starr; Neil Upton
Latency to paroxetine-induced anxiolysis in the rat is reduced by co-administration of the 5-HT(1A) receptor antagonist WAY100635.
British journal of pharmacology 2000;130(7):1713-9.
2000: Carol Routledge; Steven M Bromidge; S F Moss; Gary W Price; Warren D Hirst; H Newman; Graham Riley; TL Gager; Tania O Stean; Neil Upton; S E Clarke; AM Brown; Derek N Middlemiss
Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.
British journal of pharmacology 2000;130(7):1606-12.
2000: Martin I Smith; Simon Read; WN Chan; Mervyn Thompson; A Jackie Hunter; Neil Upton; Andrew A Parsons
Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453.
Cephalalgia : an international journal of headache 2000;20(6):546-53.
2000: James Hagan; Gary W Price; Phillip Jeffrey; Nigel J Deeks; Tania O Stean; DC Piper; Martin I Smith; Neil Upton; Andrew D Medhurst; Derek N Middlemiss; Graham J Riley; Peter J Lovell; Steven M Bromidge; David R Thomas
Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.
British journal of pharmacology 2000;130(3):539-48.
2000: Simon Read; Martin I Smith; A Jackie Hunter; Neil Upton; Andrew A Parsons
SB-220453, a potential novel antimigraine agent, inhibits nitric oxide release following induction of cortical spreading depression in the anaesthetized cat.
Cephalalgia : an international journal of headache 2000;20(2):92-9.
2000: DC Piper; Neil Upton; Martin I Smith; A Jackie Hunter
The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats.
The European journal of neuroscience 2000;12(2):726-30.
2000: Neil Upton; Mervyn Thompson
Benzo[b]pyranols and related novel antiepileptic agents.
Progress in medicinal chemistry 2000;37():177-200.
1999: James Hagan; Ronald A Leslie; S Patel; ML Evans; T A Wattam; S Holmes; Christopher D Benham; SG Taylor; Carol Routledge; P Hemmati; Richard Munton; Tracey E Ashmeade; A S Shah; Jonathan P Hatcher; Paula D Hatcher; Declan N C Jones; Martin I Smith; DC Piper; A Jackie Hunter; Rod A Porter; Neil Upton
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10911-6.
1999: Andrew Billinton; Neil Upton; Norman G Bowery
GABA(B) receptor isoforms GBR1a and GBR1b, appear to be associated with pre- and post-synaptic elements respectively in rat and human cerebellum.
British journal of pharmacology 1999;126(6):1387-92.
1999: WN Chan; JM Evans; Michael S Hadley; Hugh J Herdon; Jeffrey C Jerman; Andrew A Parsons; Simon Read; Tania O Stean; Mervyn Thompson; Neil Upton
Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent.
Bioorganic & medicinal chemistry letters 1999;9(2):285-90.
1998: WN Chan; Michael S Hadley; John D Harling; Hugh J Herdon; Jeffrey C Jerman; Barry Orlek; Tania O Stean; Mervyn Thompson; Neil Upton; Robert W Ward
Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl-benzamides with potential anticonvulsant activity.
Bioorganic & medicinal chemistry letters 1998;8(20):2903-6.
1998: Neil Upton; Tania O Stean; Derek N Middlemiss; Thomas Blackburn; Guy A Kennett
Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents.
European journal of pharmacology 1998;359(1):33-40.
1998: Jackie Cilia; DC Piper; Neil Upton; James Hagan
A comparison of rectal and subcutaneous body temperature measurement in the common marmoset.
Journal of pharmacological and toxicological methods 1998;40(1):21-6.
1998: Ian T Forbes; S Dabbs; DM Duckworth; AJ Jennings; Frank D King; Peter J Lovell; AM Brown; LJ Collin; James Hagan; Derek N Middlemiss; Graham J Riley; David R Thomas; Neil Upton
(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.
Journal of medicinal chemistry 1998;41(5):655-7.
1997: Hugh J Herdon; Jeffrey C Jerman; Tania O Stean; Derek N Middlemiss; WN Chan; Antonio K K Vong; JM Evans; Mervyn Thompson; Neil Upton
Characterization of the binding of [3H]-SB-204269, a radiolabelled form of the new anticonvulsant SB-204269, to a novel binding site in rat brain membranes.
British journal of pharmacology 1997;121(8):1687-91.
1997: Neil Upton; Thomas Blackburn; Colin A Campbell; D Cooper; ML Evans; Hugh J Herdon; PD King; Alison M Ray; Tania O Stean; WN Chan; JM Evans; Mervyn Thompson
Profile of SB-204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures.
British journal of pharmacology 1997;121(8):1679-86.
1997: Guy A Kennett; Martyn D Wood; F Bright; Brenda K Trail; Graham Riley; Vicky Holland; KY Avenell; Tania O Stean; Neil Upton; Steven M Bromidge; Ian T Forbes; AM Brown; Derek N Middlemiss; Thomas Blackburn
SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.
Neuropharmacology 1997;36(4-5):609-20.
1996: WN Chan; J M Evans; Michael S Hadley; Hugh J Herdon; Jeffrey C Jerman; H K Morgan; Tania O Stean; Mervyn Thompson; Neil Upton; Antonio K K Vong
Synthesis of novel trans-4-(substituted-benzamido)-3,4-dihydro-2H-benzo[b]-pyran-3-ol derivatives as potential anticonvulsant agents with a distinctive binding profile.
Journal of medicinal chemistry 1996;39(23):4537-9.
1996: Hugh J Herdon; Jeffrey C Jerman; Tania O Stean; W Chan; Derek N Middlemiss; Neil Upton
The novel anticonvulsant SB 204269 binds to a stereospecific site in the mouse brain.
European journal of pharmacology 1996;314(3):R7-8.
1994: Neil Upton
Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings.
Trends in pharmacological sciences 1994;15(12):456-63.
1993: Thomas Blackburn; G S Baxter; Guy A Kennett; Frank D King; DC Piper; GJ Sanger; D R Thomas; Neil Upton; Martyn D Wood
BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties.
Psychopharmacology 1993;110(3):257-64.
1990: Ian T Forbes; C N Johnson; GE Jones; J Loudon; J M Nicholass; Mervyn Thompson; Neil Upton
Synthesis and evaluation of a series of aryl[e]fused pyrazolo[4,3-c]pyridines with potential anxiolytic activity.
Journal of medicinal chemistry 1990;33(9):2640-5.