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Patricia Upton

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Kun Lu; Benjamin C Moeller; Husamettin Gul; Patricia B Upton; James A Swenberg
Formation of hydroxymethyl DNA adducts in rats orally exposed to stable isotope labeled methanol.
Esra Mutlu; Patricia B Upton; Darrell W Winsett; Leonard B Collins; Paul Evansky; Amy-Joan L Ham; Gary Hatch; Yo-Chan Jeong; James A Swenberg
A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-Oxoethyl)guanine in sprague-dawley rats.
James A Swenberg; Narisa K Bordeerat; Gunnar Boysen; Sujey Carro; Nadia I Georgieva; Jun Nakamura; John M Troutman; Patricia B Upton; Richard J Albertini; Pamela M Vacek; Vernon E Walker; Radim J Sram; Melissa Goggin; Natalia Tretyakova
1,3-Butadiene: Biomarkers and application to risk assessment.

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All Publications

2012: Kun Lu; Benjamin C Moeller; Husamettin Gul; Patricia B Upton; James A Swenberg
Formation of hydroxymethyl DNA adducts in rats orally exposed to stable isotope labeled methanol.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(1):28-38.
2012: Esra Mutlu; Patricia B Upton; Darrell W Winsett; Leonard B Collins; Paul Evansky; Amy-Joan L Ham; Gary Hatch; Yo-Chan Jeong; James A Swenberg
A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-Oxoethyl)guanine in sprague-dawley rats.
Chemical research in toxicology 2012;25(2):391-9.
2011: James A Swenberg; Narisa K Bordeerat; Gunnar Boysen; Sujey Carro; Nadia I Georgieva; Jun Nakamura; John M Troutman; Patricia B Upton; Richard J Albertini; Pamela M Vacek; Vernon E Walker; Radim J Sram; Melissa Goggin; Natalia Tretyakova
1,3-Butadiene: Biomarkers and application to risk assessment.
Chemico-biological interactions 2011;192(1-2):150-4.
2011: James A Swenberg; Kun Lu; Benjamin C Moeller; Lina Gao; Patricia B Upton; Jun Nakamura; Thomas B Starr
Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment.
Toxicological sciences : an official journal of the Society of Toxicology 2011;120 Suppl 1():S130-45.
2010: Pamela M Vacek; Richard J Albertini; Radim J Sram; Patricia B Upton; James A Swenberg
Hemoglobin adducts in 1,3-butadiene exposed Czech workers: female-male comparisons.
Chemico-biological interactions 2010;188(3):668-76.
2010: Esra Mutlu; Leonard B Collins; Matthew D Stout; Patricia B Upton; Laura R Daye; Darrell Winsett; Gary Hatch; Paul Evansky; James A Swenberg
Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N(2),3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC.
Chemical research in toxicology 2010;23(9):1485-91.
2009: Vernon E Walker; Dale M Walker; Quanxin Meng; Jacob D McDonald; Bobby R Scott; Steven K Seilkop; David J Claffey; Patricia B Upton; Mark W Powley; James A Swenberg; Rogene F Henderson
Genotoxicity of 1,3-butadiene and its epoxy intermediates.
Research report (Health Effects Institute) 2009;(144):3-79.
2009: Dale M Walker; Adriana E Kajon; Salina M Torres; Meghan M Carter; Consuelo L McCash; James A Swenberg; Patricia B Upton; Andrew W Hardy; Ofelia A Olivero; Gene M Shearer; Miriam C Poirier; Vernon E Walker
WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.
Environmental and molecular mutagenesis 2009;50(6):460-72.
2008: Matthew D Stout; Elmarie Bodes; Robert Schoonhoven; Patricia B Upton; Gregory S Travlos; James A Swenberg
Toxicity, DNA binding, and cell proliferation in male F344 rats following short-term gavage exposures to trans-2-hexenal.
Toxicologic pathology 2008;36(2):232-46.
2007: Lynn H Pottenger; Linda A Malley; Matthew S Bogdanffy; E Maria Donner; Patricia B Upton; Yutai Li; Vernon E Walker; Jack R Harkema; Marcy I Banton; James A Swenberg
Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):336-47.
2007: Mark W Powley; Vernon E Walker; Yutai Li; Patricia B Upton; James A Swenberg
The importance of 3,4-epoxy-1,2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-diol associated mutagenicity.
Chemico-biological interactions 2007;166(1-3):182-90.
2007: Gunnar Boysen; Nadia I Georgieva; Patricia B Upton; Vernon E Walker; James A Swenberg
N-terminal globin adducts as biomarkers for formation of butadiene derived epoxides.
Chemico-biological interactions 2007;166(1-3):84-92.
2007: Quanxin Meng; Dale M Walker; Jacob D McDonald; Rogene F Henderson; Meghan M Carter; Dennis L Cook; Consuelo L McCash; Salina M Torres; Michael J Bauer; Steven K Seilkop; Patricia B Upton; Nadia I Georgieva; Gunnar Boysen; James A Swenberg; Vernon E Walker
Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene.
Chemico-biological interactions 2007;166(1-3):121-31.
2007: Nadia I Georgieva; Gunnar Boysen; Patricia B Upton; Karupiah Jayaraj; Avram Gold; James A Swenberg
Quantitative analysis of N-terminal valine peptide adducts specific for 1,2-epoxy-3-butene.
Chemico-biological interactions 2007;166(1-3):219-25.
2005: Ivan Rusyn; Shoji Asakura; Yutai Li; Oksana Kosyk; Hasan Koc; Jun Nakamura; Patricia B Upton; James A Swenberg
Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver.
DNA repair 2005;4(10):1099-110.
2005: Mark W Powley; Yutai Li; Patricia B Upton; Vernon E Walker; James A Swenberg
Quantification of DNA and hemoglobin adducts of 3,4-epoxy-1,2-butanediol in rodents exposed to 3-butene-1,2-diol.
Carcinogenesis 2005;26(9):1573-80.
2005: Yo-Chan Jeong; Jun Nakamura; Patricia B Upton; James A Swenberg
Pyrimido[1,2-a]-purin-10(3H)-one, M1G, is less prone to artifact than base oxidation.
Nucleic acids research 2005;33(19):6426-34.
2004: Gunnar Boysen; Nadia I Georgieva; Patricia B Upton; Karupiah Jayaraj; Yutai Li; Vernon E Walker; James A Swenberg
Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene.
Cancer research 2004;64(23):8517-20.
2003: Richard J Albertini; Radim J Srám; Pamela M Vacek; Jeremiah Lynch; Janice A Nicklas; Nico J van Sittert; Peter J Boogaard; Rogene F Henderson; James A Swenberg; Ad D Tates; Jonathan B Ward; Michael Wright; Marinel M Ammenheuser; Blanka Binkova; Walter B Blackwell; Franz A de Zwart; Dean Krako; Jennifer Krone; Hendricus Megens; Petra Musilová; Gabriela Rajská; Asoka Ranasinghe; Judah I Rosenblatt; Pavel Rössner; Jiri Rubes; Linda Sullivan; Patricia B Upton; Ailko H Zwinderman
Biomarkers in Czech workers exposed to 1,3-butadiene: a transitional epidemiologic study.
Research report (Health Effects Institute) 2003;(116):1-141; discussion 143-62.
2002: Melva N Ríos-Blanco; Asoka Ranasinghe; Patricia B Upton; Moung S Lee; Johannes G Filser; James A Swenberg
Exposure-dependent accumulation of N-(2-hydroxypropyl)valine in hemoglobin of F344 rats exposed to propylene oxide by the inhalation route.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;778(1-2):383-91.
2002: Eric J Morinello; Amy-Joan L Ham; Asoka Ranasinghe; Jun Nakamura; Patricia B Upton; James A Swenberg
Molecular dosimetry and repair of N(2),3-ethenoguanine in rats exposed to vinyl chloride.
Cancer research 2002;62(18):5189-95.
2002: James A Swenberg; Amy-Joan L Ham; Hasan Koc; David K La; Eric J Morinello; Brian F Pachkowski; Asoka Ranasinghe; Patricia B Upton
Methods for measuring DNA adducts and abasic sites II: methods for measurement of DNA adducts.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2002;Chapter 3():Unit3.9.
2002: Po-Hsiung Lin; David K La; Patricia B Upton; James A Swenberg
Analysis of DNA adducts in rats exposed to pentachlorophenol.
Carcinogenesis 2002;23(2):365-9.
2001: Petra Begemann; Patricia B Upton; Asoka Ranasinghe; James A Swenberg; Leonardo Soleo; Luigi Vimercati; A Gelormini; Silvia Fustinoni; I Zwirner-Baier; Hans-Günter Neumann
Hemoglobin adducts as biomarkers of 1,3-butadiene in occupationally low exposed Italian workers and a few diesel-exposed miners.
Chemico-biological interactions 2001;135-136():675-8.
2001: James A Swenberg; Hasan Koc; Patricia B Upton; N Georguieva; Asoka Ranasinghe; Vernon E Walker; R Henderson
Using DNA and hemoglobin adducts to improve the risk assessment of butadiene.
Chemico-biological interactions 2001;135-136():387-403.
2001: Quanxin Meng; Rogene F Henderson; L Long; L Blair; Dale M Walker; Patricia B Upton; James A Swenberg; Vernon E Walker
Mutagenicity at the Hprt locus in T cells of female mice following inhalation exposures to low levels of 1,3-butadiene.
Chemico-biological interactions 2001;135-136():343-61.
2001: Po-Hsiung Lin; Jun Nakamura; S Yamaguchi; David K La; Patricia B Upton; James A Swenberg
Induction of direct adducts, apurinic/apyrimidinic sites and oxidized bases in nuclear DNA of human HeLa S3 tumor cells by tetrachlorohydroquinone.
Carcinogenesis 2001;22(4):635-9.
2001: Po-Hsiung Lin; Jun Nakamura; S Yamaguchi; Patricia B Upton; David K La; James A Swenberg
Oxidative damage and direct adducts in calf thymus DNA induced by the pentachlorophenol metabolites, tetrachlorohydroquinone and tetrachloro-1,4-benzoquinone.
Carcinogenesis 2001;22(4):627-34.
2000: Ivan Rusyn; Mikhail F Denissenko; Victoria A Wong; Byron E Butterworth; Michael L Cunningham; Patricia B Upton; Ronald G Thurman; James A Swenberg
Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency.
Carcinogenesis 2000;21(12):2141-5.
2000: Vernon E Walker; KY Wu; Patricia B Upton; Asoka Ranasinghe; N Scheller; M H Cho; J S Vergnes; Thomas R Skopek; James A Swenberg
Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide.
Carcinogenesis 2000;21(9):1661-9.
2000: Po-Hsiung Lin; Ramiah Sangaiah; Asoka Ranasinghe; Patricia B Upton; David K La; Avram Gold; James A Swenberg
Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5, 5'-tetrachlorobiphenyl.
Chemical research in toxicology 2000;13(8):710-8.
2000: S Holt; G Roy; S Mitra; Patricia B Upton; Matthew S Bogdanffy; James A Swenberg
Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride.
Mutation research 2000;460(2):105-15.
2000: James A Swenberg; N I Christova-Gueorguieva; Patricia B Upton; Asoka Ranasinghe; N Scheller; KY Wu; TY Yen; R Hayes
1,3-butadiene: cancer, mutations, and adducts. Part V: Hemoglobin adducts as biomarkers of 1,3-butadiene exposure and metabolism.
Research report (Health Effects Institute) 2000;(92):191-210; discussion 211-9.
2000: James A Swenberg; Amy-Joan L Ham; Hasan Koc; Eric J Morinello; Asoka Ranasinghe; NY Tretyakova; Patricia B Upton; K Wu
DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene.
Mutation research 2000;464(1):77-86.
1999: Vernon E Walker; I M Jones; T L Crippen; Quanxin Meng; Dale M Walker; Michael J Bauer; AA Reilly; A D Tates; Jun Nakamura; Patricia B Upton; Thomas R Skopek
Relationships between exposure, cell loss and proliferation, and manifestation of Hprt mutant T cells following treatment of preweanling, weanling, and adult male mice with N-ethyl-N-nitrosourea.
Mutation research 1999;431(2):371-88.
1999: Amy-Joan L Ham; Asoka Ranasinghe; Eric J Morinello; Jun Nakamura; Patricia B Upton; F Johnson; James A Swenberg
Immunoaffinity/gas chromatography/high-resolution mass spectrometry method for the detection of N(2),3-ethenoguanine.
Chemical research in toxicology 1999;12(12):1240-6.
1999: KY Wu; Asoka Ranasinghe; Patricia B Upton; Vernon E Walker; James A Swenberg
Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents.
Carcinogenesis 1999;20(9):1787-92.
1999: James A Swenberg; Matthew S Bogdanffy; Amy-Joan L Ham; S Holt; A Kim; Eric J Morinello; Asoka Ranasinghe; N Scheller; Patricia B Upton
Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis.
IARC scientific publications 1999;(150):29-43.
1999: Vernon E Walker; JL Andrews; Patricia B Upton; Thomas R Skopek; J G deBoer; Dale M Walker; X Shi; HE Sussman; Nancy J Gorelick
Detection of cyclophosphamide-induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice.
Environmental and molecular mutagenesis 1999;34(2-3):167-81.
1998: Asoka Ranasinghe; N Scheller; KY Wu; Patricia B Upton; James A Swenberg
Application of gas chromatography/electron capture negative chemical ionization high-resolution mass spectrometry for analysis of DNA and protein adducts.
Chemical research in toxicology 1998;11(5):520-6.
1998: Jun Nakamura; Vernon E Walker; Patricia B Upton; SY Chiang; Y W Kow; James A Swenberg
Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions.
Cancer research 1998;58(2):222-5.
1997: Vernon E Walker; S C Sisk; Patricia B Upton; Brian A Wong; Leslie Recio
In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure.
Mutation research 1997;392(3):211-22.
1997: NY Tretyakova; Y Lin; Ramiah Sangaiah; Patricia B Upton; James A Swenberg
Identification and quantitation of DNA adducts from calf thymus DNA exposed to 3,4-epoxy-1-butene.
Carcinogenesis 1997;18(1):137-47.
1996: Y P Lin; Patricia B Upton; Ramiah Sangaiah; James A Swenberg
Macromolecular adducts of butadiene.
Toxicology 1996;113(1-3):70-6.
1993: Vernon E Walker; Timothy R Fennell; Patricia B Upton; J P MacNeela; James A Swenberg
Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide.
Environmental health perspectives 1993;99():11-7.
1992: Vernon E Walker; Timothy R Fennell; Patricia B Upton; Thomas R Skopek; V Prevost; D E Shuker; James A Swenberg
Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice.
Cancer research 1992;52(16):4328-34.