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Masaharu Urakaze

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Chemicals & Drugs

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Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Kenta Kambara; Yukiko Koshimizu; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Seisuke Okazawa; Masakiyo Sasahara; Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Yu Yamazaki; Ryuji Hayashi; Kazuyuki Tobe
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Ryuji Hayashi; Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Hirofumi Ogawa; Ikuo Saiki; Hiroaki Sakurai; Kazuyuki Tobe
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
H Suzuki; S Takasawa; K Tobe; Masaharu Urakaze; Isao Usui; Y Yamazaki; S Senda; Shiho Fujisaka; Y Ishii; Yukiko Kanatani; I Kato; Masashi Kobayashi; A Mahmood; H Okamoto; T Oya; M Sasahara
Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca²⁺/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice.

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All Publications

2013: Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Kenta Kambara; Yukiko Koshimizu; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Seisuke Okazawa; Masakiyo Sasahara; Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Yu Yamazaki; Ryuji Hayashi; Kazuyuki Tobe
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Respirology (Carlton, Vic.) 2013;18(2):332-9.
2012: Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Ryuji Hayashi; Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Hirofumi Ogawa; Ikuo Saiki; Hiroaki Sakurai; Kazuyuki Tobe
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Oncology reports 2012;27(6):1726-32.
2011: H Suzuki; S Takasawa; K Tobe; Masaharu Urakaze; Isao Usui; Y Yamazaki; S Senda; Shiho Fujisaka; Y Ishii; Yukiko Kanatani; I Kato; Masashi Kobayashi; A Mahmood; H Okamoto; T Oya; M Sasahara
Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca²⁺/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice.
Diabetologia 2011;54(11):2953-62.
2010: Yasuo Fukushima; Masaharu Urakaze; Kazuyuki Tobe
[Metabolic syndrome].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(2):299-304.
2009: Yu Yamazaki; Koichi tsuneyama; Masaharu Urakaze; Isao Usui; Agussalim Bukhari; Shiho Fujisaka; Ryuji Hayashi; Kazuya Hirata; Shingo Imanishi; Manabu Ishiki; Yukiko Kanatani; Masashi Kobayashi; Yuji Matsuya; Hideo Nemoto; Satoko Senda; Hikari Suzuki; Kazuyuki Tobe
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.
American journal of physiology. Endocrinology and metabolism 2009;297(5):E1179-86.
2009: Shiho Fujisaka; Isao Usui; Agussalim Bukhari; Masashi Ikutani; Takeshi Oya; Yukiko Kanatani; Koichi tsuneyama; Yoshinori Nagai; Kiyoshi Takatsu; Masaharu Urakaze; Masashi Kobayashi; Kazuyuki Tobe
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.
Diabetes 2009;58(11):2574-82.
2009: Sachie Asamizu; Masaharu Urakaze; Chikaaki Kobashi; Manabu Ishiki; Amal Khalifa Norel Din; Shiho Fujisaka; Yukiko Kanatani; Agussalim Bukahari; Satoko Senda; Hikari Suzuki; Yuh Yamazaki; Minoru Iwata; Isao Usui; Katsuya Yamazaki; Hirofumi Ogawa; Hiroshi Ogawa; Masashi Kobayashi; Kazuyuki Tobe
Angiotensin II enhances the increase in monocyte chemoattractant protein-1 production induced by tumor necrosis factor-{alpha} from 3T3-L1 preadipocytes.
The Journal of endocrinology 2009;202(2):199-205.
2009: Chikaaki Kobashi; Sachie Asamizu; Manabu Ishiki; Minoru Iwata; Isao Usui; Katusuya Yamazaki; Kazuyuki Tobe; Masashi Kobayashi; Masaharu Urakaze
Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway.
Journal of inflammation (London, England) 2009;6():25.
2008: T Uno; J He; Isao Usui; Yukiko Kanatani; Agussalim Bukhari; Shiho Fujisaka; Y Yamazaki; H Suzuki; Minoru Iwata; Manabu Ishiki; Masaharu Urakaze; Tetsuro Haruta; H Ogawa; Masashi Kobayashi
Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(1):8-12.
2007: Isao Usui; Shiho Fujisaka; Katsuya Yamazaki; Atsuko Takano; Shiho Murakami; Yu Yamazaki; Masaharu Urakaze; Haruo Hachiya; Michiyo Takata; Satoko Senda; Minoru Iwata; Akira Satoh; Toshiyasu Sasaoka; Norel Dim Ak; Rie Temaru; Masashi Kobayashi
Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients.
Diabetes research and clinical practice 2007;77(2):210-4.
2007: Ken Ishizuka; Isao Usui; Yukiko Kanatani; Agussalim Bukhari; Jianying He; Shiho Fujisaka; Yu Yamazaki; Hikari Suzuki; Kazuyuki Hiratani; Manabu Ishiki; Minoru Iwata; Masaharu Urakaze; Tetsuro Haruta; Masashi Kobayashi
Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes.
Endocrinology 2007;148(6):2994-3003.
2007: Yukiko Kanatani; Isao Usui; Ken Ishizuka; Agussalim Bukhari; Shiho Fujisaka; Masaharu Urakaze; Tetsuro Haruta; Tadamitsu Kishimoto; Tetsuji Naka; Masashi Kobayashi
Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.
Diabetes 2007;56(3):795-803.
2005: Chikaaki Kobashi; Masaharu Urakaze; Mika Kishida; Etsuko Kibayashi; Hideki Kobayashi; Shinji Kihara; Tohru Funahashi; Michiyo Takata; Rie Temaru; Akira Sato; Katsuya Yamazaki; Norio Nakamura; Masashi Kobayashi
Adiponectin inhibits endothelial synthesis of interleukin-8.
Circulation research 2005;97(12):1245-52.
2005: Mika Kishida; Masaharu Urakaze; Masanobu Takata; Y Nobata; N Yamamoto; Rie Temaru; Akira Sato; Katsuya Yamazaki; Norio Nakamura; Masashi Kobayashi
PGE1 inhibits the expression of PAI-1 mRNA induced by TNF-alpha in human mesangial cells.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2005;113(7):365-71.
2005: Etsuko Kibayashi; Masaharu Urakaze; Chikaaki Kobashi; Mika Kishida; Michiyo Takata; Akira Sato; Katsuya Yamazaki; Masashi Kobayashi
Inhibitory effect of pitavastatin (NK-104) on the C-reactive-protein-induced interleukin-8 production in human aortic endothelial cells.
Clinical science (London, England : 1979) 2005;108(6):515-21.
2003: Hajime Ishihara; Toshiyasu Sasaoka; Syota Kagawa; Shihou Murakami; Kazuhito Fukui; Yukio Kawagishi; Katsuya Yamazaki; Akira Sato; Minoru Iwata; Masaharu Urakaze; Manabu Ishiki; Tsutomu Wada; Saori Yaguchi; Hiroshi Tsuneki; Ikuko Kimura; Masashi Kobayashi
Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population.
FEBS letters 2003;554(3):450-4.
2003: Norio Nakamura; Katsuya Yamazaki; Akira Satoh; Masaharu Urakaze; Masashi Kobayashi; Hideaki Yamabe; Hiroshi Osawa; Ken-Ichi Shirato; Toshiyuki Sugawara; Masayuki Nakamura; Michiko Tamura; Ken Okumura
Effects of eparlestat on plasma levels of advanced glycation end products in patients with type 2 diabetes.
In vivo (Athens, Greece) 2003;17(2):177-80.
2003: Norio Nakamura; Tomohito Hamazaki; H Johkaji; S Minami; Katsuya Yamazaki; Akira Satoh; Shigeki Sawazaki; Masaharu Urakaze; Masashi Kobayashi; Hiroshi Osawa; Hideaki Yamabe; K Okomura
Effects of cilostazol on serum lipid concentrations and plasma fatty acid composition in type 2 diabetic patients with peripheral vascular disease.
Clinical and experimental medicine 2003;2(4):180-4.
2002: Y Nobata; Masaharu Urakaze; Rie Temaru; Akira Sato; Norio Nakamura; Katsuya Yamazaki; Mika Kishida; Masanobu Takata; Masashi Kobayashi
alpha-Tocopherol Inhibits IL-8 synthesis induced by thrombin and high glucose in endothelial cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(2):49-54.
2001: Masanobu Takata; Masaharu Urakaze; Rie Temaru; Katsuya Yamazaki; Norio Nakamura; Y Nobata; Mika Kishida; Akira Sato; Masashi Kobayashi
Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase.
British journal of pharmacology 2001;134(4):753-62.
2001: Akira Sato; Toshiyasu Sasaoka; Katsuya Yamazaki; Norio Nakamura; Rie Temaru; Manabu Ishiki; Masanobu Takata; Mika Kishida; Tsutomu Wada; Hajime Ishihara; Isao Usui; Masaharu Urakaze; Masashi Kobayashi
Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via phosphatidylinositol 3-kinase pathway in rat aortic smooth muscle cells.
Atherosclerosis 2001;157(2):341-52.
1999: Norio Nakamura; Tomohito Hamazaki; M Ohta; K Okuda; Masaharu Urakaze; Shigeki Sawazaki; Katsuya Yamazaki; Akira Satoh; Rie Temaru; Y Ishikura; Masanobu Takata; Mika Kishida; Masashi Kobayashi
Joint effects of HMG-CoA reductase inhibitors and eicosapentaenoic acids on serum lipid profile and plasma fatty acid concentrations in patients with hyperlipidemia.
International journal of clinical & laboratory research 1999;29(1):22-5.
1997: Rie Temaru; Masaharu Urakaze; A Satou; Katsuya Yamazaki; Norio Nakamura; Masashi Kobayashi
High glucose enhances the gene expression of interleukin-8 in human endothelial cells, but not in smooth muscle cells: possible role of interleukin-8 in diabetic macroangiopathy.
Diabetologia 1997;40(5):610-3.
1996: Masaharu Urakaze; Rie Temaru; A Satou; Katsuya Yamazaki; Tomohito Hamazaki; Masashi Kobayashi
The IL-8 production in endothelial cells is stimulated by high glucose.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(8):400-1.
1996: Y Takada; Yoshimi Takata; M Iwanishi; T Imamura; T Sawa; H Morioka; Hajime Ishihara; Manabu Ishiki; Isao Usui; Rie Temaru; Masaharu Urakaze; Y Satoh; T Inami; S Tsuda; Masashi Kobayashi
Effect of glimepiride (HOE 490) on insulin receptors of skeletal muscles from genetically diabetic KK-Ay mouse.
European journal of pharmacology 1996;308(2):205-10.
1996: D R Robinson; Masaharu Urakaze; R Huang; Hirofumi Taki; E Sugiyama; C T Knoell; L Xu; E T Yeh; Philip E. auron
Dietary marine lipids suppress continuous expression of interleukin-1 beta gene transcription.
Lipids 1996;31 Suppl():S23-31.
1995: D R Robinson; C T Knoell; Masaharu Urakaze; R Huang; Hirofumi Taki; E Sugiyama; L L Xu; E T Yeh; W Olesiak; M Guo
Suppression of autoimmune disease by omega-3 fatty acids.
Biochemical Society transactions 1995;23(2):287-91.
1994: D R Robinson; L L Xu; C T Knoell; S Tateno; M Guo; Robert Colvin; W Olesiak; Masaharu Urakaze; E Sugiyama; Philip E. auron
Alleviation of autoimmune disease by omega 3 fatty acids.
World review of nutrition and dietetics 1994;76():95-102.
1992: Shigeki Sawazaki; Norio Nakamura; Tomohito Hamazaki; Katsuya Yamazaki; Masaharu Urakaze; S Yano
Intravenous infusion of trieicosapentaenoyl-glycerol and LTB4 and LTB5 production by leukocytes of rabbits.
The American journal of physiology 1992;262(6 Pt 2):H1711-8.
1992: Masaharu Urakaze; T Kamitani; R DeGasperi; E Sugiyama; H M Chang; C D Warren; E T Yeh
Identification of a missing link in glycosylphosphatidylinositol anchor biosynthesis in mammalian cells.
The Journal of biological chemistry 1992;267(10):6459-62.
1992: L J Thomas; Masaharu Urakaze; R DeGasperi; T Kamitani; E Sugiyama; H M Chang; C D Warren; E T Yeh
Differential expression of glycosylphosphatidylinositol-anchored proteins in a murine T cell hybridoma mutant producing limiting amounts of the glycolipid core. Implications for paroxysmal nocturnal hemoglobinuria.
The Journal of clinical investigation 1992;89(4):1172-7.
1992: J F Mahoney; Masaharu Urakaze; S Hall; R DeGasperi; H M Chang; E Sugiyama; C D Warren; Michael J Borowitz; A Nicholson-Weller; Wendell F Rosse
Defective glycosylphosphatidylinositol anchor synthesis in paroxysmal nocturnal hemoglobinuria granulocytes.
Blood 1992;79(6):1400-3.
1991: L J Thomas; R DeGasperi; E Sugiyama; H M Chang; P J Beck; P Orlean; Masaharu Urakaze; T Kamitani; J F Sambrook; C D Warren
Functional analysis of T-cell mutants defective in the biosynthesis of glycosylphosphatidylinositol anchor. Relative importance of glycosylphosphatidylinositol anchor versus N-linked glycosylation in T-cell activation.
The Journal of biological chemistry 1991;266(34):23175-84.
1991: E Sugiyama; R DeGasperi; Masaharu Urakaze; H M Chang; L J Thomas; R Hyman; C D Warren; E T Yeh
Identification of defects in glycosylphosphatidylinositol anchor biosynthesis in the Thy-1 expression mutants.
The Journal of biological chemistry 1991;266(19):12119-22.
1990: Tomohito Hamazaki; E Takazakura; K Osawa; Masaharu Urakaze; S Yano
Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester.
Lipids 1990;25(9):541-5.
1989: M Fujikawa; Katsuya Yamazaki; Shigeki Sawazaki; Hirofumi Taki; M Kaneda; Masaharu Urakaze; Tomohito Hamazaki; S Yano; T Fujita
Effect of eicosapentaenoic acid ethyl ester on proteinuria of streptozotocin-induced diabetes mellitus in rats.
Lipids 1989;24(9):765-8.
1989: Masaharu Urakaze; Tomohito Hamazaki; S Yano
Fish oil and hypertension.
Journal of human hypertension 1989;3(4):277-8.
1989: Tomohito Hamazaki; S Fischer; Masaharu Urakaze; Shigeki Sawazaki; S Yano; T Kuwamori
Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake.
Prostaglandins 1989;37(4):417-24.
1989: Masaharu Urakaze; Tomohito Hamazaki; S Yano; H Kashiwabara; K Oomori; T Yokoyama
Effect of fish oil concentrate on risk factors of cardiovascular complications in renal transplantation.
Transplantation proceedings 1989;21(1 Pt 2):2134-6.
1989: Masaharu Urakaze; Tomohito Hamazaki; H Kashiwabara; K Omori; S Fischer; S Yano; A Kumagai
Favorable effects of fish oil concentrate on risk factors for thrombosis in renal allograft recipients.
Nephron 1989;53(2):102-9.
1988: Tomohito Hamazaki; Masaharu Urakaze; Shigeki Sawazaki; Katsuya Yamazaki; Hirofumi Taki; S Yano
Comparison of pulse wave velocity of the aorta between inhabitants of fishing and farming villages in Japan.
Atherosclerosis 1988;73(2-3):157-60.
1988: Tomohito Hamazaki; S Fischer; Horst Schweer; C O Meese; Masaharu Urakaze; A Yokoyama; S Yano
The infusion of trieicosapentaenoyl-glycerol into humans and the in vivo formation of prostaglandin I3 and thromboxane A3.
Biochemical and biophysical research communications 1988;151(3):1386-94.
1987: Tomohito Hamazaki; Masaharu Urakaze; S Yano; Y Soda; A Miyamoto; K Kubota; F Ibuki
Injection of tridocosahexaenoyl-glycerol emulsion and fatty acid composition of blood cells.
Lipids 1987;22(12):1031-4.
1987: Tomohito Hamazaki; Masaharu Urakaze; M Makuta; A Ozawa; Y Soda; H Tatsumi; S Yano; A Kumagai
Intake of different eicosapentaenoic acid-containing lipids and fatty acid pattern of plasma lipids in the rats.
Lipids 1987;22(12):994-8.
1987: Masaharu Urakaze; Tomohito Hamazaki; M Makuta; F Ibuki; S Kobayashi; S Yano; A Kumagai
Infusion of fish oil emulsion: effects on platelet aggregation and fatty acid composition in phospholipids of plasma, platelets, and red blood cell membranes in rabbits.
The American journal of clinical nutrition 1987;46(6):936-40.
1986: Masaharu Urakaze; Tomohito Hamazaki; Y Soda; A Miyamoto; F Ibuki; S Yano; A Kumagai
Infusion of emulsified trieicosapentaenoyl-glycerol into rabbits--the effects on platelet aggregation, polymorphonuclear leukocyte adhesion, and fatty acid composition in plasma and platelet phospholipids.
Thrombosis research 1986;44(5):673-82.
1986: Tomohito Hamazaki; S Fischer; Masaharu Urakaze; Shigeki Sawazaki; S Yano
Comparison of the urinary metabolites of prostacyclin and thromboxane of the 2- and 3-series in a Japanese fishing and a Japanese farming village.
Prostaglandins 1986;32(5):655-64.
1985: Tomohito Hamazaki; S Kobayashi; Masaharu Urakaze; S Yano; T Fujita
Viscosities of some triglycerides and ethylester of fatty acids frequently found in cell membranes--a possible effect of viscosity of fatty acids in phospholipids on hemorheology.
Biorheology 1985;22(3):221-6.