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Ina Urbatsch

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TOP 3
Douglas J Swartz; Joachim Weber; Ina L Urbatsch
P-glycoprotein is fully active after multiple tryptophan substitutions.
Christian Schölz; David Parcej; Christer S Ejsing; Horst Robenek; Ina L Urbatsch; Robert Tampé
Specific lipids modulate the transporter associated with antigen processing (TAP).
Houchao Tao; Yue Weng; Rupeng Zhuo; Geoffrey Chang; Ina L Urbatsch; Qinghai Zhang
Design and synthesis of Selenazole-containing peptides for cocrystallization with P-glycoprotein.

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All Publications

2013: Douglas J Swartz; Joachim Weber; Ina L Urbatsch
P-glycoprotein is fully active after multiple tryptophan substitutions.
Biochimica et biophysica acta 2013;1828(3):1159-68.
2011: Christian Schölz; David Parcej; Christer S Ejsing; Horst Robenek; Ina L Urbatsch; Robert Tampé
Specific lipids modulate the transporter associated with antigen processing (TAP).
The Journal of biological chemistry 2011;286(15):13346-56.
2011: Houchao Tao; Yue Weng; Rupeng Zhuo; Geoffrey Chang; Ina L Urbatsch; Qinghai Zhang
Design and synthesis of Selenazole-containing peptides for cocrystallization with P-glycoprotein.
Chembiochem : a European journal of chemical biology 2011;12(6):868-73.
2011: Jiangping Bai; Christie G Brouillette; Geoffrey Chang; Brigitte Gasser; Patina M Harrell; Ellen Hildebrandt; Diethard Mattanovich; Irina I Protasevich; Douglas J Swartz; Andrew Ward; Ina L Urbatsch
A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris.
PloS one 2011;6(8):e22577.
2010: Andrea D Hoffman; Ina L Urbatsch; Pia D Vogel
Nucleotide binding to the human multidrug resistance protein 3, MRP3.
The protein journal 2010;29(5):373-9.
2010: Brandy J Harvey Johnson; Jyh-Yeuan Lee; Amanda Pickert; Ina L Urbatsch
Bile acids stimulate ATP hydrolysis in the purified cholesterol transporter ABCG5/G8.
Biochemistry 2010;49(16):3403-11.
2010: Daniel A P Gutmann; Andrew Ward; Ina L Urbatsch; Geoffrey A. Chang; Hendrik W Van Veen
Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1.
Trends in biochemical sciences 2010;35(1):36-42.
2009: Britta Zehnpfennig; Ina L Urbatsch; Hans-Joachim Galla
Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity.
Biochemistry 2009;48(20):4423-30.
2009: Stephen G Aller; Jodie Yu; Andrew Ward; Yue Weng; Srinivas Chittaboina; Rupeng Zhuo; Patina M Harrell; Yenphuong T Trinh; Qinghai Zhang; Ina L Urbatsch; Geoffrey A. Chang
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science (New York, N.Y.) 2009;323(5922):1718-22.
2008: Jyh-Yeuan Lee; Ina L Urbatsch; Alan E Senior; Stephan Wilkens
Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.
The Journal of biological chemistry 2008;283(9):5769-79.
2007: Maria Chloupkova; Amanda Pickert; Jyh-Yeuan Lee; Shiloe Souza; Yenphuong T Trinh; Sara M Connelly; Mark E Dumont; Michael Dean; Ina L Urbatsch
Expression of 25 human ABC transporters in the yeast Pichia pastoris and characterization of the purified ABCC3 ATPase activity.
Biochemistry 2007;46(27):7992-8003.
2007: Isabelle Carrier; Ina L Urbatsch; Alan E Senior; Philippe Gros
Mutational analysis of conserved aromatic residues in the A-loop of the ABC transporter ABCB1A (mouse Mdr3).
FEBS letters 2007;581(2):301-8.
2006: Zhanling Wang; Lindsay D Stalcup; Brandy J Harvey; Joachim Weber; Maria Chloupkova; Mark E Dumont; Michael Dean; Ina L Urbatsch
Purification and ATP hydrolysis of the putative cholesterol transporters ABCG5 and ABCG8.
Biochemistry 2006;45(32):9929-39.
2006: Gregory Tombline; Ina L Urbatsch; Navneet Virk; Alma Muharemagic; Lori Bartholomew White; Alan E Senior
Expression, purification, and characterization of cysteine-free mouse P-glycoprotein.
Archives of biochemistry and biophysics 2006;445(1):124-8.
2005: Sabine Delannoy; Ina L Urbatsch; Gregory Tombline; Alan E Senior; Pia Vogel
Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy.
Biochemistry 2005;44(42):14010-9.
2004: Gregory Tombline; Lori A Bartholomew; Grace A Tyndall; Khursheed Gimi; Ina L Urbatsch; Alan E Senior
Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues.
The Journal of biological chemistry 2004;279(45):46518-26.
2004: Gregory Tombline; Lori A Bartholomew; Ina L Urbatsch; Alan E Senior
Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly.
The Journal of biological chemistry 2004;279(30):31212-20.
2003: Ina L Urbatsch; Grace A Tyndall; Gregory Tombline; Alan E Senior
P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state.
The Journal of biological chemistry 2003;278(25):23171-9.
2002: Jyh-Yeuan Lee; Ina L Urbatsch; Alan E Senior; Stephan Wilkens
Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains.
The Journal of biological chemistry 2002;277(42):40125-31.
2001: Ina L Urbatsch; Khursheed Gimi; Susan Wilke-Mounts; nicole lerner-marmarosh; M E Rousseau; P Gros; Alan E Senior
Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein.
The Journal of biological chemistry 2001;276(29):26980-7.
2001: Ina L Urbatsch; Susan Wilke-Mounts; Khursheed Gimi; Alan E Senior
Purification and characterization of N-glycosylation mutant mouse and human P-glycoproteins expressed in Pichia pastoris cells.
Archives of biochemistry and biophysics 2001;388(1):171-7.
2000: Ina L Urbatsch; Michel Julien; Isabelle Carrier; M E Rousseau; R Cayrol; Philippe Gros
Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein.
Biochemistry 2000;39(46):14138-49.
2000: Ina L Urbatsch; Khursheed Gimi; Susan Wilke-Mounts; Alan E Senior
Investigation of the role of glutamine-471 and glutamine-1114 in the two catalytic sites of P-glycoprotein.
Biochemistry 2000;39(39):11921-7.
2000: Ina L Urbatsch; Khursheed Gimi; Susan Wilke-Mounts; Alan E Senior
Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.
The Journal of biological chemistry 2000;275(32):25031-8.
2000: T Kwan; H Loughrey; M Brault; Samantha Gruenheid; Ina L Urbatsch; Alan E Senior; Philippe Gros
Functional analysis of a tryptophan-less P-glycoprotein: a tool for tryptophan insertion and fluorescence spectroscopy.
Molecular pharmacology 2000;58(1):37-47.
1999: nicole lerner-marmarosh; Khursheed Gimi; Ina L Urbatsch; P Gros; Alan E Senior
Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.
The Journal of biological chemistry 1999;274(49):34711-8.
1998: Alan E Senior; P Gros; Ina L Urbatsch
Residues in P-glycoprotein catalytic sites that react with the inhibitor 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole.
Archives of biochemistry and biophysics 1998;357(1):121-5.
1998: Philippe Gros; L Beaudet; Ina L Urbatsch
Yeast as an expression system for the study of P-glycoprotein and other ABC transporters.
Acta physiologica Scandinavica. Supplementum 1998;643():219-25.
1998: L Beaudet; Ina L Urbatsch; Philippe Gros
Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity.
Biochemistry 1998;37(25):9073-82.
1998: Ina L Urbatsch; L Beaudet; Isabelle Carrier; Philippe Gros
Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.
Biochemistry 1998;37(13):4592-602.
1998: Alan E Senior; Marwan Al-Shawi; Ina L Urbatsch
ATPase activity of Chinese hamster P-glycoprotein.
Methods in enzymology 1998;292():514-23.
1998: L Beaudet; Ina L Urbatsch; Philippe Gros
High-level expression of mouse Mdr3 P-glycoprotein in yeast Pichia pastoris and characterization of ATPase activity.
Methods in enzymology 1998;292():397-413.
1995: Alan E Senior; Marwan Al-Shawi; Ina L Urbatsch
The catalytic cycle of P-glycoprotein.
FEBS letters 1995;377(3):285-9.
1995: Ina L Urbatsch; B Sankaran; Sumedha Bhagat; Alan E Senior
Both P-glycoprotein nucleotide-binding sites are catalytically active.
The Journal of biological chemistry 1995;270(45):26956-61.
1995: Ina L Urbatsch; B Sankaran; Joachim Weber; Alan E Senior
P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site.
The Journal of biological chemistry 1995;270(33):19383-90.
1995: Alan E Senior; Marwan Al-Shawi; Ina L Urbatsch
ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells.
Journal of bioenergetics and biomembranes 1995;27(1):31-6.
1995: Ina L Urbatsch; Alan E Senior
Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein.
Archives of biochemistry and biophysics 1995;316(1):135-40.
1994: Ina L Urbatsch; Marwan Al-Shawi; Alan E Senior
Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein.
Biochemistry 1994;33(23):7069-76.
1994: Marwan Al-Shawi; Ina L Urbatsch; Alan E Senior
Covalent inhibitors of P-glycoprotein ATPase activity.
The Journal of biological chemistry 1994;269(12):8986-92.