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Julio Urbina

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Guiomar Pérez-Moreno; Carlos Rodrigues-Poveda; Luis M Ruiz-Pérez; Marco Sealey-Cardona; Julio A Urbina; Víctor Castillo-Acosta; Michael H Gelb; Dolores González-Pacanowska
Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.
Phercyles Veiga-Santos; Júlio F C Santos; Julio A Urbina; Emile S Barrias; Thiago Luiz de Barros Moreira; Tecia Maria Ulisses de Carvalho; Wanderley de Souza
Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi.
Carlos A Rodrígues-Poveda; Dolores González-Pacanowska; Guiomar Pérez-Moreno; Julio A Urbina; Antonio E Vidal; Luis M Ruiz-Pérez
Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.

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2012: Guiomar Pérez-Moreno; Carlos Rodrigues-Poveda; Luis M Ruiz-Pérez; Marco Sealey-Cardona; Julio A Urbina; Víctor Castillo-Acosta; Michael H Gelb; Dolores González-Pacanowska
Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.
International journal for parasitology 2012;42(11):975-89.
2012: Phercyles Veiga-Santos; Júlio F C Santos; Julio A Urbina; Emile S Barrias; Thiago Luiz de Barros Moreira; Tecia Maria Ulisses de Carvalho; Wanderley de Souza
Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi.
International journal of antimicrobial agents 2012;40(1):61-71.
2012: Carlos A Rodrígues-Poveda; Dolores González-Pacanowska; Guiomar Pérez-Moreno; Julio A Urbina; Antonio E Vidal; Luis M Ruiz-Pérez
Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.
Molecular and biochemical parasitology 2012;182(1-2):83-7.
2011: Kelly Ishida; Juliany C F Rodrigues; Julio A Urbina; Gonzalo Visbal; Wanderley de Souza; Sonia Rozental
Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2011;17(4):563-70.
2011: Sara Teixeira de Macedo-Silva; Thais Larissa Araújo de Oliveira Silva; Wanderley de Souza; Julio A Urbina; Juliany Cola Fernandes Rodrigues
Antiproliferative, Ultrastructural, and Physiological Effects of Amiodarone on Promastigote and Amastigote Forms of Leishmania amazonensis.
Molecular biology international 2011;2011():876021.
2011: Kelly Ishida; Juliany Cola Fernandes Rodrigues; Simon Cammerer; Julio A Urbina; Ian H Gilbert; Wanderley de Souza; Sonia Rozental
Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis.
Annals of clinical microbiology and antimicrobials 2011;10():3.
2011: Daniel Adesse; Eduardo Meirelles Azzam; Maria de Nazareth L Meirelles; Julio A Urbina; Luciana R Garzoni
Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro.
Antimicrobial agents and chemotherapy 2011;55(1):203-10.
2010: Bianca P Olivieri; Judith Tibisay Molina; Solange L de Castro; M C S Pereira; Claudia M Calvet; Julio A Urbina; Tania C Araújo-Jorge
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
International journal of antimicrobial agents 2010;36(1):79-83.
2010: Julio A Urbina
Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches.
Acta tropica 2010;115(1-2):55-68.
2009: Julio A Urbina
Ergosterol biosynthesis and drug development for Chagas disease.
Memórias do Instituto Oswaldo Cruz 2009;104 Suppl 1():311-8.
2009: Eduardo Caio Torres-Santos; Maria Isabel Sampaio-Santos; Frederick S Buckner; Kohei Yokoyama; Michael Gelb; Julio A Urbina; Bartira Rossi-Bergmann
Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.
The Journal of antimicrobial chemotherapy 2009;63(3):469-72.
2009: Kelly Ishida; Juliany Cola Fernandes Rodrigues; Marcos Dornelas Ribeiro; Taíssa Vieira Machado Vila; Wanderley de Souza; Julio A Urbina; Celso Vataru Nakamura; Sonia Rozental
Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms.
BMC microbiology 2009;9():74.
2008: Juliany Cola Fernandes Rodrigues; Juan Luis Concepcion; Carlos Rodrigues; Aura Caldera; Julio A Urbina; Wanderley de Souza
In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects.
Antimicrobial agents and chemotherapy 2008;52(11):4098-114.
2008: Carmen Jiménez-Jiménez; Juana Carrero-Lérida; Marco Sealey-Cardona; Luis M Ruiz-Pérez; Julio A Urbina; Dolores González-Pacanowska
Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.
Molecular and biochemical parasitology 2008;160(1):52-9.
2007: Claudia Maia; Marcia Attias; Julio A Urbina; Ian H Gilbert; Filippo Magaraci; Wanderley de Souza
Azasterols impair Giardia lamblia proliferation and induces encystation.
Biochemical and biophysical research communications 2007;363(2):310-6.
2007: Simon Cammerer; Carmen Jimenez; Simon Jones; Ludovic Gros; Silvia Orenes; Carlos Rodrigues; Juliany C F Rodrigues; Aura Caldera; Luis M Ruiz-Perez; Wanderley da Souza; Marcel Kaiser; Reto Brun; Julio A Urbina; Dolores Gonzalez-Pacanowska; Ian H Gilbert
Quinuclidine derivatives as potential antiparasitics.
Antimicrobial agents and chemotherapy 2007;51(11):4049-61.
2007: Juliany C F Rodrigues; Celene F Bernardes; Gonzalo Visbal; Julio A Urbina; Anibal E Vercesi; Wanderley de Souza
Sterol methenyl transferase inhibitors alter the ultrastructure and function of the Leishmania amazonensis mitochondrion leading to potent growth inhibition.
Protist 2007;158(4):447-56.
2007: Marco Sealey-Cardona; Simon Cammerer; Simon Jones; Luis M Ruiz-Pérez; Reto Brun; Ian H Gilbert; Julio A Urbina; Dolores González-Pacanowska
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
Antimicrobial agents and chemotherapy 2007;51(6):2123-9.
2007: Ana Claudia Granthon; Marina V Braga; Juliany C F Rodrigues; Simon Cammerer; Silvia Orenes; Ian H Gilbert; Julio A Urbina; Wanderley de Souza
Alterations on the growth and ultrastructure of Leishmania chagasi induced by squalene synthase inhibitors.
Veterinary parasitology 2007;146(1-2):25-34.
2007: Carlos Sanz-Rodríguez; Juan L Concepción; Sara Pekerar; Eric Oldfield; Julio A Urbina
Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies.
The Journal of biological chemistry 2007;282(17):12377-87.
2006: Julio A Urbina
Mechanisms of action of lysophospholipid analogues against trypanosomatid parasites.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2006;100 Suppl 1():S9-S16.
2006: Ludovic Gros; Victor Manuel Castillo-Acosta; Carmen Jiménez Jiménez; Marco Sealey-Cardona; Sofia Vargas; Antonio Manuel Estévez; Vanessa Yardley; Lauren Rattray; Simon L Croft; Luis M Ruiz-Perez; Julio A Urbina; Ian H Gilbert; Dolores González-Pacanowska
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.
Antimicrobial agents and chemotherapy 2006;50(8):2595-601.
2006: Erica S Martins-Duarte; Julio A Urbina; Wanderley de Souza; Rossiane C Vommaro
Antiproliferative activities of two novel quinuclidine inhibitors against Toxoplasma gondii tachyzoites in vitro.
The Journal of antimicrobial chemotherapy 2006;58(1):59-65.
2006: Dayse T Silva; Maria de Nazareth S L de Meirelles; Danielle Almeida; Julio A Urbina; M C S Pereira
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors.
International journal of antimicrobial agents 2006;27(6):530-7.
2006: Gustavo Benaim; John M Sanders; Yael Garcia-Marchán; Claudia Colina; Renee Lira; Aura Caldera; gilberto payares; cristina sanoja; Juan M Burgos; Annette Leon-Rossell; Juan Luis Concepcion; Alejandro G Schijman; Mariano Levin; Eric Oldfield; Julio A Urbina
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
Journal of medicinal chemistry 2006;49(3):892-9.
2006: Isabella Vieira Palmié-Peixoto; Marcia Rosa Rocha; Julio A Urbina; Wanderley de Souza; Marcelo Einicker-Lamas; Maria Cristina M Motta
Effects of sterol biosynthesis inhibitors on endosymbiont-bearing trypanosomatids.
FEMS microbiology letters 2006;255(1):33-42.
2006: Michael P Hudock; Carlos Sanz-Rodríguez; Yongcheng Song; Julian M W Chan; Yonghui Zhang; Sarah Odeh; Thomas Kosztowski; Annette Leon-Rossell; J L Concepción; Vanessa Yardley; Simon L Croft; Julio A Urbina; Eric Oldfield
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Journal of medicinal chemistry 2006;49(1):215-23.
2005: Juliany C F Rodrigues; Julio A Urbina; Wanderley de Souza
Antiproliferative and ultrastructural effects of BPQ-OH, a specific inhibitor of squalene synthase, on Leishmania amazonensis.
Experimental parasitology 2005;111(4):230-8.
2005: Silvia Orenes Lorente; Rosario Gómez; Carmen Jiménez; Simon Cammerer; Vanessa Yardley; Kate de Luca-Fradley; Simon L Croft; Luis M Ruiz-Perez; Julio A Urbina; Dolores Gonzalez-Pacanowska; Ian H Gilbert
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa.
Bioorganic & medicinal chemistry 2005;13(10):3519-29.
2005: Ricardo Santa Rita; Renee Lira; Helene Santos Barbosa; Julio A Urbina; Solange L de Castro
Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis.
The Journal of antimicrobial chemotherapy 2005;55(5):780-4.
2005: Lucas Dantas-Leite; Julio A Urbina; Wanderley de Souza; Rossiane C Vommaro
Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii.
International journal of antimicrobial agents 2005;25(2):130-5.
2004: Silvia Orenes; Juliany C F Rodrigues; Carmen Jiménez Jiménez; Miranda Joyce-Menekse; Carlos Rodrigues; Simon L Croft; Vanessa Yardley; Kate de Luca-Fradley; Luis M Ruiz-Pérez; Julio A Urbina; Wanderley de Souza; Dolores González-Pacanowska; Ian H Gilbert
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
Antimicrobial agents and chemotherapy 2004;48(8):2937-50.
2004: Marina V Braga; Julio A Urbina; Wanderley de Souza
Effects of squalene synthase inhibitors on the growth and ultrastructure of Trypanosoma cruzi.
International journal of antimicrobial agents 2004;24(1):72-8.
2004: Julio A Urbina; Juan Luis Concepcion; Aura Caldera; gilberto payares; cristina sanoja; Takeshi Otomo; Hironobu Hiyoshi
In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi.
Antimicrobial agents and chemotherapy 2004;48(7):2379-87.
2004: Lucas Dantas-Leite; Julio A Urbina; Wanderley de Souza; Rossiane C Vommaro
Selective anti-Toxoplasma gondii activities of azasterols.
International journal of antimicrobial agents 2004;23(6):620-6.
2004: Luciana R Garzoni; Mariana C Waghabi; Marcos M Baptista; Solange L de Castro; Maria de Nazareth L Meirelles; Constança Britto; Roberto Docampo; Eric Oldfield; Julio A Urbina
Antiparasitic activity of risedronate in a murine model of acute Chagas' disease.
International journal of antimicrobial agents 2004;23(3):286-90.
2004: Luciana R Garzoni; Aura Caldera; Maria de Nazareth L Meirelles; Solange L de Castro; Roberto Docampo; Gary A Meints; Eric Oldfield; Julio A Urbina
Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi.
International journal of antimicrobial agents 2004;23(3):273-85.
2003: Julio A Urbina; Roberto Docampo
Specific chemotherapy of Chagas disease: controversies and advances.
Trends in parasitology 2003;19(11):495-501.
2003: Filippo Magaraci; Carmen Jimenez Jimenez; Carlos Rodrigues; Juliany C F Rodrigues; Marina V Braga; Vanessa Yardley; Kate de Luca-Fradley; Simon L Croft; Wanderley de Souza; Luis M Ruiz-Perez; Julio A Urbina; Dolores Gonzalez-Pacanowska; Ian H Gilbert
Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.
Journal of medicinal chemistry 2003;46(22):4714-27.
2003: Julio A Urbina; Juan Luis Concepcion; Andrea Montalvetti; Juan B Rodriguez; Roberto Docampo
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.
Antimicrobial agents and chemotherapy 2003;47(6):2047-50.
2003: Julio A Urbina; gilberto payares; cristina sanoja; Judith Molina; Renee Lira; Zigman Brener; Alvaro J Romanha
Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains.
International journal of antimicrobial agents 2003;21(1):39-48.
2003: Julio A Urbina; gilberto payares; cristina sanoja; Renee Lira; Alvaro J Romanha
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease.
International journal of antimicrobial agents 2003;21(1):27-38.
2002: Julio A Urbina; Juan Luis Concepcion; Salomé Rangel; Gonzalo Visbal; Renee Lira
Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana.
Molecular and biochemical parasitology 2002;125(1-2):35-45.
2002: Benjamin Moreno; Claudia Rodrigues; Brian N Bailey; Julio A Urbina; Silvia N J Moreno; Roberto Docampo; Eric Oldfield
Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible.
FEBS letters 2002;523(1-3):207-12.
2002: Noris Rodriguez; Brian N Bailey; Michael B Martin; Eric Oldfield; Julio A Urbina; Roberto Docampo
Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate.
The Journal of infectious diseases 2002;186(1):138-40.
2002: Juliany C F Rodrigues; Marcia Attias; Carlos Rodriguez; Julio A Urbina; Wanderley de Souza
Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis.
Antimicrobial agents and chemotherapy 2002;46(2):487-99.
2002: Julio A Urbina
Chemotherapy of Chagas disease.
Current pharmaceutical design 2002;8(4):287-95.
2001: Maribel Navarro; Efrén J Cisneros-Fajardo; T Lehmann; Roberto A Sánchez-Delgado; Reinaldo Atencio; Pedro Silva; Renee Lira; Julio A Urbina
Toward a novel metal-based chemotherapy against tropical diseases. 6. Synthesis and characterization of new copper(II) and gold(I) clotrimazole and ketoconazole complexes and evaluation of their activity against Trypanosoma cruzi.
Inorganic chemistry 2001;40(27):6879-84.
2001: Reinaldo Atencio; Gonzalo Visbal; S Pekerar; J Papale; Julio A Urbina
Studies of molecular structure parameters of 20-piperidin-2-yl-5alpha-pregnan-3beta,20-diol and its N-methyl derivative: two inhibitors of Delta24(25) sterol methyl transferase and Delta24(24') sterol methyl reductase of Trypanosoma cruzi.
Acta crystallographica. Section B, Structural science 2001;57(Pt 5):714-21.
2001: Claudia Rodrigues; Rosana Catisti; Sergio A Uyemura; Anibal E Vercesi; Renee Lira; C Rodriguez; Julio A Urbina; Roberto Docampo
The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in different sensitivity to digitonin-permeabilization.
The Journal of eukaryotic microbiology 2001;48(5):588-94.
2001: Renee Lira; L M Contreras; R M Rita; Julio A Urbina
Mechanism of action of anti-proliferative lysophospholipid analogues against the protozoan parasite Trypanosoma cruzi: potentiation of in vitro activity by the sterol biosynthesis inhibitor ketoconazole.
The Journal of antimicrobial chemotherapy 2001;47(5):537-46.
2001: Michael B Martin; Joshua S Grimley; Jared C Lewis; H T Heath; Brian N Bailey; Howard Kendrick; Vanessa Yardley; Aura Caldera; Renee Lira; Julio A Urbina; Silvia N J Moreno; Roberto Docampo; Simon L Croft; Eric Oldfield
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
Journal of medicinal chemistry 2001;44(6):909-16.
2001: Judith Molina; Julio A Urbina; R Gref; Zigman Brener
Cure of experimental Chagas' disease by the bis-triazole DO870 incorporated into 'stealth' polyethyleneglycol-polylactide nanospheres.
The Journal of antimicrobial chemotherapy 2001;47(1):101-4.
2000: Benjamin Moreno; Julio A Urbina; Eric Oldfield; Brian N Bailey; Claudia Rodrigues; Roberto Docampo
31P NMR spectroscopy of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Evidence for high levels of condensed inorganic phosphates.
The Journal of biological chemistry 2000;275(37):28356-62.
2000: Julio A Urbina; Renee Lira; Gonzalo Visbal; J Bartrolí
In vitro antiproliferative effects and mechanism of action of the new triazole derivative UR-9825 against the protozoan parasite Trypanosoma (Schizotrypanum) cruzi.
Antimicrobial agents and chemotherapy 2000;44(9):2498-502.
2000: Claudia Rodrigues; David A Scott; Brian N Bailey; Wanderley de Souza; Marlene Benchimol; Benjamin Moreno; Julio A Urbina; Eric Oldfield; Silvia N J Moreno
Vacuolar proton pyrophosphatase activity and pyrophosphate (PPi) in Toxoplasma gondii as possible chemotherapeutic targets.
The Biochemical journal 2000;349 Pt 3():737-45.
2000: Judith Molina; Zigman Brener; Alvaro J Romanha; Julio A Urbina
In vivo activity of the bis-triazole D0870 against drug-susceptible and drug-resistant strains of the protozoan parasite Trypanosoma cruzi.
The Journal of antimicrobial chemotherapy 2000;46(1):137-40.
2000: Judith Molina; Olindo Martins-Filho; Zigman Brener; Alvaro J Romanha; D Loebenberg; Julio A Urbina
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts.
Antimicrobial agents and chemotherapy 2000;44(1):150-5.
1999: Julio A Urbina; Benjamin Moreno; S Vierkotter; Eric Oldfield; gilberto payares; cristina sanoja; Brian N Bailey; W Yan; David A Scott; Silvia N J Moreno; Roberto Docampo
Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs.
The Journal of biological chemistry 1999;274(47):33609-15.
1999: Marcos André Vannier-Santos; A Martiny; Ulysses Lins; Julio A Urbina; VM Borges; Wanderley de Souza
Impairment of sterol biosynthesis leads to phosphorus and calcium accumulation in Leishmania acidocalcisomes.
Microbiology (Reading, England) 1999;145 ( Pt 11)():3213-20.
1999: A Liendo; Gonzalo Visbal; Marta Piras; Romano Piras; Julio A Urbina
Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes.
Molecular and biochemical parasitology 1999;104(1):81-91.
1999: Michael B Martin; W Arnold; H T Heath; Julio A Urbina; Eric Oldfield
Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis.
Biochemical and biophysical research communications 1999;263(3):754-8.
1999: Julio A Urbina
Chemotherapy of Chagas' disease: the how and the why.
Journal of molecular medicine (Berlin, Germany) 1999;77(3):332-8.
1999: Julio A Urbina
Parasitological cure of Chagas disease: is it possible? Is it relevant?
Memórias do Instituto Oswaldo Cruz 1999;94 Suppl 1():349-55.
1998: Julio A Urbina; gilberto payares; L M Contreras; A Liendo; cristina sanoja; Judith Molina; Marta Piras; Romano Piras; N Perez; P Wincker; D Loebenberg
Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Antimicrobial agents and chemotherapy 1998;42(7):1771-7.
1998: Juan Luis Concepcion; Dolores Gonzalez-Pacanowska; Julio A Urbina
3-Hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: subcellular localization and kinetic properties.
Archives of biochemistry and biophysics 1998;352(1):114-20.
1998: A Liendo; K Lazardi; Julio A Urbina
In-vitro antiproliferative effects and mechanism of action of the bis-triazole D0870 and its S(-) enantiomer against Trypanosoma cruzi.
The Journal of antimicrobial chemotherapy 1998;41(2):197-205.
1997: Julio A Urbina; Gonzalo Visbal; L M Contreras; G McLaughlin; Roberto Docampo
Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii.
Antimicrobial agents and chemotherapy 1997;41(7):1428-32.
1997: Gioconda San-Blas; Julio A Urbina; E Marchán; L M Contreras; Françoise Sorais; F San-Blas
Inhibition of Paracoccidioides brasiliensis by ajoene is associated with blockade of phosphatidylcholine biosynthesis.
Microbiology (Reading, England) 1997;143 ( Pt 5)():1583-6.
1997: L M Contreras; J Vivas; Julio A Urbina
Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors.
Biochemical pharmacology 1997;53(5):697-704.
1997: J Vivas; Julio A Urbina; W de Souza
Ultrastructural alterations in Trypanosoma (Schizotrypanum) cruzi induced by Delta(24(25)) sterol methyl transferase inhibitors and their combinations with ketoconazole.
International journal of antimicrobial agents 1997;8(1):1-6.
1996: Hector Rangel; Fracehuli Dagger; A Hernandez; A Liendo; Julio A Urbina
Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes.
Antimicrobial agents and chemotherapy 1996;40(12):2785-91.
1996: J Vivas; Julio A Urbina; W de Souza
Ultrastructural alterations in Trypanosoma (Schizotrypanum) cruzi induced by Delta(24(25)) sterol methyl transferase inhibitors and their combinations with ketoconazole.
International journal of antimicrobial agents 1996;7(4):235-40.
1996: Julio A Urbina; gilberto payares; J Molina; cristina sanoja; A Liendo; K Lazardi; M M Piras; R Piras; N Perez; P Wincker; J F Ryley
Cure of short- and long-term experimental Chagas' disease using D0870.
Science (New York, N.Y.) 1996;273(5277):969-71.
1996: Julio A Urbina; J Vivas; K Lazardi; J Molina; gilberto payares; M M Piras; R Piras
Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Chemotherapy 1996;42(4):294-307.
1996: R A Sánchez-Delgado; M Navarro; H Pérez; Julio A Urbina
Toward a novel metal-based chemotherapy against tropical diseases. 2. Synthesis and antimalarial activity in vitro and in vivo of new ruthenium- and rhodium-chloroquine complexes.
Journal of medicinal chemistry 1996;39(5):1095-99.
1995: Julio A Urbina; S Pekerar; H B Le; J Patterson; B Montez; Eric Oldfield
Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparative study using 2H-, 13C- and 31P-NMR spectroscopy.
Biochimica et biophysica acta 1995;1238(2):163-76.
1995: Julio A Urbina; J Vivas; Gonzalo Visbal; L M Contreras
Modification of the sterol composition of Trypanosoma (Schizotrypanum) cruzi epimastigotes by delta 24(25)-sterol methyl transferase inhibitors and their combinations with ketoconazole.
Molecular and biochemical parasitology 1995;73(1-2):199-210.
1993: B Montez; Eric Oldfield; Julio A Urbina; S Pekerar; C Husted; J Patterson
Editing 13C-NMR spectra of membranes.
Biochimica et biophysica acta 1993;1152(2):314-8.
1993: R A Sánchez-Delgado; K Lazardi; L Rincón; Julio A Urbina
Toward a novel metal-based chemotherapy against tropical diseases. 1. Enhancement of the efficacy of clotrimazole against Trypanosoma cruzi by complexation to ruthenium in RuCl2(clotrimazole)2.
Journal of medicinal chemistry 1993;36(14):2041-3.
1993: Julio A Urbina; E Marchan; K Lazardi; Gonzalo Visbal; Rafael Apitz-Castro; F Gil; T Aguirre; M M Piras; R Piras
Inhibition of phosphatidylcholine biosynthesis and cell proliferation in Trypanosoma cruzi by ajoene, an antiplatelet compound isolated from garlic.
Biochemical pharmacology 1993;45(12):2381-7.
1993: R A Maldonado; J Molina; gilberto payares; Julio A Urbina
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease.
Antimicrobial agents and chemotherapy 1993;37(6):1353-9.
1993: Julio A Urbina; K Lazardi; E Marchan; Gonzalo Visbal; T Aguirre; M M Piras; R Piras; R A Maldonado; gilberto payares; W de Souza
Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Antimicrobial agents and chemotherapy 1993;37(3):580-91.
1993: Julio A Urbina; I Machin; L Jurado
The limitations of paradigms: studies on the intermediary metabolism of Trypanosoma cruzi.
Biological research 1993;26(1-2):81-8.
1991: K Lazardi; Julio A Urbina; W de Souza
Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi.
Antimicrobial agents and chemotherapy 1991;35(4):736-40.
1991: Julio A Urbina; K Lazardi; T Aguirre; M M Piras; R Piras
Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.
Antimicrobial agents and chemotherapy 1991;35(4):730-5.
1990: K Lazardi; Julio A Urbina; W de Souza
Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.
Antimicrobial agents and chemotherapy 1990;34(11):2097-105.
1990: Julio A Urbina; C E Osorno; A Rojas
Inhibition of phosphoenolpyruvate carboxykinase from Trypanosoma (Schizotrypanum) cruzi epimastigotes by 3-mercaptopicolinic acid: in vitro and in vivo studies.
Archives of biochemistry and biophysics 1990;282(1):91-9.
1990: Julio A Urbina; X Ysern; A S Mildvan
Involvement of a divalent cation in the binding of fructose 6-phosphate to Trypanosoma cruzi phosphofructokinase: kinetic and magnetic resonance studies.
Archives of biochemistry and biophysics 1990;278(1):187-94.
1990: Gustavo Benaim; R Bermudez; Julio A Urbina
Ca2+ transport in isolated mitochondrial vesicles from Leishmania braziliensis promastigotes.
Molecular and biochemical parasitology 1990;39(1):61-8.
1988: Julio A Urbina; K Lazardi; T Aguirre; M M Piras; R Piras
Antiproliferative synergism of the allylamine SF 86-327 and ketoconazole on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.
Antimicrobial agents and chemotherapy 1988;32(8):1237-42.
1988: Julio A Urbina; J Vivas; H Ramos; G Larralde; Z Aguilar; L Avilán
Alteration of lipid order profile and permeability of plasma membranes from Trypanosoma cruzi epimastigotes grown in the presence of ketoconazole.
Molecular and biochemical parasitology 1988;30(2):185-95.
1988: R Maingon; R Gerke; M Rodriguez; Julio A Urbina; J Hoenicka; S Negri; T Aguirre; Jan Nehlin; T Knapp; J Crampton
The tubulin genes of Trypanosoma cruzi.
European journal of biochemistry / FEBS 1988;171(1-2):285-91.
1988: G Larralde; J Vivas; Julio A Urbina
Concentration and time dependence of the effects of ketoconazole on growth and sterol synthesis by Trypanosoma (Schizotrypanum) cruzi epimastigotes.
Acta científica venezolana 1988;39(2):140-6.
1988: Julio A Urbina; K Lazardi; G Larralde; T Aguirre; M M Piras; R Piras
Synergistic effects of ketoconazole and SF-86327 on the proliferation of epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.
Annals of the New York Academy of Sciences 1988;544():357-8.
1987: Julio A Urbina
The phosphoenolpyruvate carboxykinase of Trypanosoma (Schizotrypanum) cruzi epimastigotes: molecular, kinetic, and regulatory properties.
Archives of biochemistry and biophysics 1987;258(1):186-95.
1986: Z Aguilar; Julio A Urbina
The phosphofructokinase of Trypanosoma (Schizotrypanum) cruzi: purification and kinetic mechanism.
Molecular and biochemical parasitology 1986;21(2):103-11.
1986: B E Cohen; H Ramos; M Gamargo; Julio A Urbina
The water and ionic permeability induced by polyene antibiotics across plasma membrane vesicles from Leishmania sp.
Biochimica et biophysica acta 1986;860(1):57-65.
1982: J Vivas; Julio A Urbina
Energy-dependent lectin-induced agglutination in Trypanosoma (Schizotrypanum) Cruzi epimastigotes.
Acta científica venezolana 1982;33(5):396-401.