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Uros Urleb

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Chemicals & Drugs

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Publications

TOP 3
Marija Petruševska; Uros Urleb; Luka Peternel
Evaluation of a high-throughput screening method for the detection of the excipient-mediated precipitation inhibition of poorly soluble drugs.
Jure Acimovic; Tina Korosec; Matej Seliskar; Ingemar Bjorkhem; Katalin Monostory; Pal Szabo; Jean-Marc Pascussi; A Belic; Uros Urleb; Darko Kocjan; Damjana Rozman
Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis.
Polona Smrdel; Manica Cerne; Marija Bogataj; Uros Urleb; Ales Mrhar
Enhanced therapeutic effect of LK-423 in treating experimentally induced colitis in rats when administered in colon delivery microcapsules.

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All Publications

2013: Marija Petruševska; Uros Urleb; Luka Peternel
Evaluation of a high-throughput screening method for the detection of the excipient-mediated precipitation inhibition of poorly soluble drugs.
Assay and drug development technologies 2013;11(2):117-29.
2011: Jure Acimovic; Tina Korosec; Matej Seliskar; Ingemar Bjorkhem; Katalin Monostory; Pal Szabo; Jean-Marc Pascussi; A Belic; Uros Urleb; Darko Kocjan; Damjana Rozman
Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(1):39-46.
2010: Polona Smrdel; Manica Cerne; Marija Bogataj; Uros Urleb; Ales Mrhar
Enhanced therapeutic effect of LK-423 in treating experimentally induced colitis in rats when administered in colon delivery microcapsules.
Journal of microencapsulation 2010;27(7):572-82.
2010: Marko Petek; Špela Baebler; Drago Kuzman; Ana Rotter; Zdravko Podlesek; Kristina Gruden; Maja Ravnikar; Uros Urleb
Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome: modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation.
BMC microbiology 2010;10():159.
2009: Polona Smrdel; Iztok Grabnar; Igor Locatelli; Manica Cerne; Samo Andrensek; Natasa Kovacic; Albin Kristl; Marija Bogataj; Uros Urleb; Ales Mrhar
Physicochemical and preclinical pharmacokinetic and toxicological evaluation of LK-423--a new phthalimido-desmuramyl-dipeptide derivative with immunomodulating activity.
Drug development and industrial pharmacy 2009;35(11):1293-304.
2009: Mihael Simcic; Milan Hodoscek; Jan Humljan; Katja Kristan; Uros Urleb; Darko Kocjan; Simona Golic Grdadolnik
NMR and molecular dynamics study of the binding mode of naphthalene-N-sulfonyl-D-glutamic acid derivatives: novel MurD ligase inhibitors.
Journal of medicinal chemistry 2009;52(9):2899-908.
2009: Katja Kristan; Miha Kotnik; Marko Oblak; Uros Urleb
New high-throughput fluorimetric assay for discovering inhibitors of UDP-N-acetylmuramyl-L-alanine: D-glutamate (MurD) ligase.
Journal of biomolecular screening 2009;14(4):412-8.
2009: Katja Kristan; Tomaž Bratkovič; Matej Sova; Stanislav Gobec; Andrej Prezelj; Uros Urleb
Novel inhibitors of beta-ketoacyl-ACP reductase from Escherichia coli.
Chemico-biological interactions 2009;178(1-3):310-6.
2009: Luka Peternel; Miha Kotnik; Andrej Prezelj; Uros Urleb
Comparison of 3 cytotoxicity screening assays and their application to the selection of novel antibacterial hits.
Journal of biomolecular screening 2009;14(2):142-50.
2009: Susanne Paukner; Lars Hesse; Andrej Prezelj; Tomaz Solmajer; Uros Urleb
In vitro activity of LK-157, a novel tricyclic carbapenem as broad-spectrum {beta}-lactamase inhibitor.
Antimicrobial agents and chemotherapy 2009;53(2):505-11.
2008: Jan Humljan; Miha Kotnik; Carlos A Contreras-Martel; Didier Blanot; Uros Urleb; Andréa Dessen; Tom Solmajer; Stanislav Gobec
Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme.
Journal of medicinal chemistry 2008;51(23):7486-94.
2008: Mojca Lunder; Tomaž Bratkovič; Uros Urleb; Samo Kreft; Borut Strukelj
Ultrasound in phage display: a new approach to nonspecific elution.
BioTechniques 2008;44(7):893-900.
2008: Tomaž Bratkovič; Mojca Lunder; Uros Urleb; Borut Strukelj
Peptide inhibitors of MurD and MurE, essential enzymes of bacterial cell wall biosynthesis.
Journal of basic microbiology 2008;48(3):202-6.
2008: Ian Chopra; Christopher Schofield; Martin Everett; Alex O'Neill; Keith Miller; Mark H Wilcox; Jean-Marie Frère; Mike Dawson; Lloyd Czaplewski; Uros Urleb; Patrice Courvalin
Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement.
The Lancet infectious diseases 2008;8(2):133-9.
2008: Tina Korosec; Jure Acimovic; Matej Seliskar; Darko Kocjan; Klementina Fon Tacer; Damjana Rozman; Uros Urleb
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).
Bioorganic & medicinal chemistry 2008;16(1):209-21.
2007: Ivan Plantan; Lovro Selic; Tomaz Mesar; Petra Stefanic Anderluh; Marko Oblak; Andrej Prezelj; Lars Hesse; Miha Andrejasic; Mateja Vilar; Dusan Turk; Andrej Kocijan; Tadeja Prevec; Gregor Vilfan; Darko Kocjan; Anton Copar; Uros Urleb; Tom Solmajer
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.
Journal of medicinal chemistry 2007;50(17):4113-21.
2007: Miha Kotnik; Jan Humljan; Carlos A Contreras-Martel; Marko Oblak; Katja Kristan; Mireille Hervé; Didier Blanot; Uros Urleb; Stanislav Gobec; Andréa Dessen; Tom Solmajer
Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase.
Journal of molecular biology 2007;370(1):107-15.
2007: I Smolnikar; Andrej Perdih; Mojca Stegnar; Andrej Prezelj; Tom Solmajer; Uros Urleb; Ales Obreza
Design, synthesis and molecular modelling of 1-amidinopiperidine thrombin inhibitors.
Die Pharmazie 2007;62(4):243-54.
2007: Andrej Prezelj; Petra Stefanic Anderluh; Luka Peternel; Uros Urleb
Recent advances in serine protease inhibitors as anticoagulant agents.
Current pharmaceutical design 2007;13(3):287-312.
2006: Tomaž Bratkovič; Ales Berlec; Tatjana Popovic; Mojca Lunder; Samo Kreft; Uros Urleb; Borut Strukelj
Engineered staphylococcal protein A's IgG-binding domain with cathepsin L inhibitory activity.
Biochemical and biophysical research communications 2006;349(1):449-53.
2006: Mateja Stempelj; Matjaz Zorko; Luka Peternel; Uros Urleb; Ilonka Ferjan
Histamine release, an undesired effect of thrombin inhibitors with basic character, is mediated through direct activation of G(i) proteins.
European journal of pharmacology 2006;538(1-3):182-7.
2006: Luka Peternel; Manica Cerne; Gorazd Drevensek; Mateja Stempelj; Uros Urleb; Lovro Stanovnik; Metka V Budihna
Inhibition of mast cell degranulation-induced drop of blood pressure with clemastine, cromolyn and compound 48/80 pretreatment.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2006;55 Suppl 1():S07-8.
2006: Luka Peternel; Mateja Stempelj; Manica Cerne; Anamarija Zega; Ales Obreza; Marko Oblak; Gorazd Drevensek; Metka V Budihna; Lovro Stanovnik; Uros Urleb
Direct thrombin inhibitors built on the azaphenylalanine scaffold provoke degranulation of mast cells.
Thrombosis and haemostasis 2006;95(2):294-300.
2006: Tina Korosec; Joze Grdadolnik; Uros Urleb; Darko Kocjan; Simona Golic Grdadolnik
Synthesis, conformation, and stereodynamics of a salt of 2-{[2-(3,4-dichlorophenyl)- ethyl]propylamino}-1-pyridin-3-ylethanol.
The Journal of organic chemistry 2006;71(2):792-5.
2005: Primoz Pristovsek; Sasa Simcic; Branka Wraber; Uros Urleb
Structure of a synthetic fragment of the lipopolysaccharide (LPS) binding protein when bound to LPS and design of a peptidic LPS inhibitor.
Journal of medicinal chemistry 2005;48(24):7911-4.
2005: Mojca Lunder; Tomaž Bratkovič; Bojan Doljak; Samo Kreft; Uros Urleb; Borut Strukelj; Nadja Plazar
Comparison of bacterial and phage display peptide libraries in search of target-binding motif.
Applied biochemistry and biotechnology 2005;127(2):125-31.
2005: Tomaž Bratkovič; Mojca Lunder; Tatjana Popovic; Samo Kreft; Boris Turk; Borut Strukelj; Uros Urleb
Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K.
Biochemical and biophysical research communications 2005;332(3):897-903.
2005: Luka Peternel; Mojca Stegnar; Gorazd Drevensek; Metka V Budihna; Mojca Bozic; Anamarija Zega; Anton Stalc; Manica Cerne; Uros Urleb
Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models.
Thrombosis and haemostasis 2005;93(3):437-42.
2004: Jernej Murn; Uros Urleb; Irena Mlinaric-Rascan
Internucleosomal DNA cleavage in apoptotic WEHI 231 cells is mediated by a chymotrypsin-like protease.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(11):1103-11.
2004: Ales Obreza; Mojca Stegnar; Alenka Trampus-Bakija; Andrej Prezelj; Uros Urleb
Synthesis and in vitro evaluation of new azaphenylalanine derivatives as serine protease inhibitors.
Die Pharmazie 2004;59(10):739-43.
2004: Ales Obreza; Mojca Stegnar; Uros Urleb
Novel non-covalent azaphenylalanine thrombin inhibitors with an aminomethyl or amino group at the P1 position.
Die Pharmazie 2004;59(9):659-67.
2004: Stanislav Gobec; Marija Sollner-Dolenc; Uros Urleb; Branka Wraber; Sasa Simcic; Metka Filipic
Modulation of cytokine production by some phthalimido-desmuramyl dipeptides and their cytotoxicity.
Farmaco (Società chimica italiana : 1989) 2004;59(5):345-52.
2004: Anamarija Zega; Gregor Mlinsek; Tom Solmajer; Alenka Trampus-Bakija; Mojca Stegnar; Uros Urleb
Thrombin inhibitors built on an azaphenylalanine scaffold.
Bioorganic & medicinal chemistry letters 2004;14(6):1563-7.
2003: Metka Filipic; P Kuhar; Bojana Zegura; Uros Urleb; Stanislav Gobec
Determination of cytotoxic activity of adamantyl-desmuramyl dipeptides.
Die Pharmazie 2003;58(6):442-3.
2001: Anamarija Zega; Gregor Mlinsek; P Sepic; S Golic Grdadolnik; Tom Solmajer; T B Tschopp; B Steiner; Danijel Kikelj; Uros Urleb
Design and structure-activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization.
Bioorganic & medicinal chemistry 2001;9(10):2745-56.
2001: Anamarija Zega; Alenka Trampus-Bakija; M Fortuna; Mojca Stegnar; T B Tschopp; B Steiner; Uros Urleb
Novel thrombin inhibitors with azaphenylalanine scaffold.
Die Pharmazie 2001;56(9):683-5.
2001: Stanislav Gobec; Uros Urleb; Sasa Simcic; Branka Wraber
Synthesis and modulation of cytokine production by two new adamantane substituted acyclic desmuramyldipeptide analogs.
Die Pharmazie 2001;56(7):523-6.
2001: Stanislav Gobec; Uros Urleb; Geneviève Auger; Didier Blanot
Synthesis and biochemical evaluation of some novel N-acyl phosphono- and phosphinoalanine derivatives as potential inhibitors of the D-glutamic acid-adding enzyme.
Die Pharmazie 2001;56(4):295-7.
2001: Bojan Doljak; Mojca Stegnar; Uros Urleb; Samo Kreft; Andrej Umek; M Ciglaric; Borut Strukelj; Tatjana Popovic
Screening for selective thrombin inhibitors in mushrooms.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2001;12(2):123-8.
2000: Marija Bogataj; Ales Mrhar; Iztok Grabnar; Z Rajtman; Peter Bukovec; Stane Srcic; Uros Urleb
The influence of magnesium stearate on the characteristics of mucoadhesive microspheres.
Journal of microencapsulation 2000;17(4):499-508.
2000: O Z Rojs; Manica Cerne; I Mrzel; Uros Urleb; S Muraoka
Immunostimulatory effects of the muramyl dipeptide analogue LK415 in chickens immunized with a vaccine strain of infectious bursal disease virus.
Acta veterinaria Hungarica 2000;48(2):237-48.
2000: Sasa Simcic; Branka Wraber; M Sollner; Uros Urleb; Stanislav Gobec
Modulation of tumour necrosis factor production with desmuramyldipeptide analogues.
Pflügers Archiv : European journal of physiology 2000;440(5 Suppl):R64-6.
1999: M Moriguchi; K Urabe; Nobuyoshi Norisada; C Ochi; Anton Stalc; Uros Urleb; Shizuko Muraoka
Therapeutic effects of LK 423, a phthalimido-desmuramyl-dipeptide compound, on dextran sulfate sodium-induced colitis in rodents through restoring their interleukin-10 producing capacity.
Arzneimittel-Forschung 1999;49(2):184-92.
1999: C Ochi; Nobuyoshi Norisada; M Moriguchi; Anton Stalc; Uros Urleb; Shizuko Muraoka
Interleukin-10 inducing activity of LK423, a phthalimido-desmuramyldipeptide compound.
Arzneimittel-Forschung 1999;49(1):72-9.