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Isao Usui

Research Profile

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Shiho Fujisaka; N Goda; M Ikutani; A Mahmood; Y Nagai; K Takatsu; A Takikawa; Koichi tsuneyama; Isao Usui; A Aminuddin; K Tobe
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.
Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Kenta Kambara; Yukiko Koshimizu; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Seisuke Okazawa; Masakiyo Sasahara; Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Yu Yamazaki; Ryuji Hayashi; Kazuyuki Tobe
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Ryuji Hayashi; Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Hirofumi Ogawa; Ikuo Saiki; Hiroaki Sakurai; Kazuyuki Tobe
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.

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All Publications

2013: Shiho Fujisaka; N Goda; M Ikutani; A Mahmood; Y Nagai; K Takatsu; A Takikawa; Koichi tsuneyama; Isao Usui; A Aminuddin; K Tobe
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.
Diabetologia 2013;56(6):1403-12.
2013: Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Kenta Kambara; Yukiko Koshimizu; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Seisuke Okazawa; Masakiyo Sasahara; Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Yu Yamazaki; Ryuji Hayashi; Kazuyuki Tobe
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.
Respirology (Carlton, Vic.) 2013;18(2):332-9.
2012: Kensuke Suzuki; Masaharu Urakaze; Isao Usui; Toru Yamada; Ryuji Hayashi; Tomomi Ichikawa; Shingo Imanishi; Minehiko Inomata; Shoko Matsui; Yuji Matsuya; Toshiro Miwa; Hirofumi Ogawa; Ikuo Saiki; Hiroaki Sakurai; Kazuyuki Tobe
SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.
Oncology reports 2012;27(6):1726-32.
2012: Isao Usui; Kazuyuki Tobe
[Roles of chronic inflammation as a pathogenesis of insulin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():191-5.
2012: Yasuharu Watanabe; Shizuo Akira; Shiho Fujisaka; Yoichiro Hirata; Yoshinori Ichihara; Sho Ishikawa; Hirofumi Izaki; Hiro-Omi Kanayama; Kensuke Miyake; Tomoya Nakamura; Yoshihiro Ogawa; Toshiyasu Sasaoka; Masataka Sata; Michio Shimabukuro; Takayoshi Suganami; Kiyoshi Takatsu; Kazuyuki Tobe; Koichi tsuneyama; Isao Usui; Tsutomu Wada; Yoshinori Nagai
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Diabetes 2012;61(5):1199-209.
2011: H Suzuki; S Takasawa; K Tobe; Masaharu Urakaze; Isao Usui; Y Yamazaki; S Senda; Shiho Fujisaka; Y Ishii; Yukiko Kanatani; I Kato; Masashi Kobayashi; A Mahmood; H Okamoto; T Oya; M Sasahara
Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca²⁺/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice.
Diabetologia 2011;54(11):2953-62.
2011: Shiho Fujisaka; Isao Usui; Yukiko Kanatani; Masashi Ikutani; Ichiro Takasaki; Koichi tsuneyama; Yoshiaki Tabuchi; Agussalim Bukhari; Yu Yamazaki; Hikari Suzuki; Satoko Senda; Aminuddin Aminuddin; Yoshinori Nagai; Kiyoshi Takatsu; Masashi Kobayashi; Kazuyuki Tobe
Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice.
Endocrinology 2011;152(5):1789-99.
2011: Isao Usui; Kazuyuki Tobe
[The role of inflammation in the development of insulin resistance in type 2 diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2011;69(3):555-62.
2011: Isao Usui; Kazuyuki Tobe
[Insulin action and its regulatory mechanisms].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 1():138-44.
2009: Yu Yamazaki; Koichi tsuneyama; Masaharu Urakaze; Isao Usui; Agussalim Bukhari; Shiho Fujisaka; Ryuji Hayashi; Kazuya Hirata; Shingo Imanishi; Manabu Ishiki; Yukiko Kanatani; Masashi Kobayashi; Yuji Matsuya; Hideo Nemoto; Satoko Senda; Hikari Suzuki; Kazuyuki Tobe
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.
American journal of physiology. Endocrinology and metabolism 2009;297(5):E1179-86.
2009: Sachie Asamizu; Masaharu Urakaze; Chikaaki Kobashi; Manabu Ishiki; Amal Khalifa Norel Din; Shiho Fujisaka; Yukiko Kanatani; Agussalim Bukahari; Satoko Senda; Hikari Suzuki; Yuh Yamazaki; Minoru Iwata; Isao Usui; Katsuya Yamazaki; Hirofumi Ogawa; Hiroshi Ogawa; Masashi Kobayashi; Kazuyuki Tobe
Angiotensin II enhances the increase in monocyte chemoattractant protein-1 production induced by tumor necrosis factor-{alpha} from 3T3-L1 preadipocytes.
The Journal of endocrinology 2009;202(2):199-205.
2009: Hikari Suzuki; Ichiro Kato; Isao Usui; Ichiro Takasaki; Yoshiaki Tabuchi; Takeshi Oya; Koichi tsuneyama; Hiroshi Kawaguchi; Koichi Hiraga; Shin Takasawa; Hiroshi Okamoto; Kazuyuki Tobe; Masakiyo Sasahara
Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.
Biochemical and biophysical research communications 2009;379(1):38-42.
2009: Chikaaki Kobashi; Sachie Asamizu; Manabu Ishiki; Minoru Iwata; Isao Usui; Katusuya Yamazaki; Kazuyuki Tobe; Masashi Kobayashi; Masaharu Urakaze
Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway.
Journal of inflammation (London, England) 2009;6():25.
2008: Tomoharu Gomi; Fusao Takusagawa; Mikio Nishizawa; Bukhari Agussalim; Isao Usui; Eiji Sugiyama; Hirofumi Taki; Kouichiro Shinoda; Hiroyuki Hounoki; Toshiro Miwa; Kazuyuki Tobe; Masashi Kobayashi; Tetsuya Ishimoto; Hirofumi Ogawa; Hisashi Mori
Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney.
Biochimica et biophysica acta 2008;1784(11):1786-94.
2008: T Uno; J He; Isao Usui; Yukiko Kanatani; Agussalim Bukhari; Shiho Fujisaka; Y Yamazaki; H Suzuki; Minoru Iwata; Manabu Ishiki; Masaharu Urakaze; Tetsuro Haruta; H Ogawa; Masashi Kobayashi
Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(1):8-12.
2007: Isao Usui; Shiho Fujisaka; Katsuya Yamazaki; Atsuko Takano; Shiho Murakami; Yu Yamazaki; Masaharu Urakaze; Haruo Hachiya; Michiyo Takata; Satoko Senda; Minoru Iwata; Akira Satoh; Toshiyasu Sasaoka; Norel Dim Ak; Rie Temaru; Masashi Kobayashi
Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients.
Diabetes research and clinical practice 2007;77(2):210-4.
2007: Ken Ishizuka; Isao Usui; Yukiko Kanatani; Agussalim Bukhari; Jianying He; Shiho Fujisaka; Yu Yamazaki; Hikari Suzuki; Kazuyuki Hiratani; Manabu Ishiki; Minoru Iwata; Masaharu Urakaze; Tetsuro Haruta; Masashi Kobayashi
Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes.
Endocrinology 2007;148(6):2994-3003.
2007: Yukiko Kanatani; Isao Usui; Ken Ishizuka; Agussalim Bukhari; Shiho Fujisaka; Masaharu Urakaze; Tetsuro Haruta; Tadamitsu Kishimoto; Tetsuji Naka; Masashi Kobayashi
Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.
Diabetes 2007;56(3):795-803.
2006: Jianying He; Isao Usui; Ken Ishizuka; Yukiko Kanatani; Kazuyuki Hiratani; Minoru Iwata; Agussalim Bukhari; Tetsuro Haruta; Toshiyasu Sasaoka; Masashi Kobayashi
Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2006;20(1):114-24.
2005: Kazuyuki Hiratani; Tetsuro Haruta; Akihiro Tani; Junko Kawahara; Isao Usui; Masashi Kobayashi
Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.
Biochemical and biophysical research communications 2005;335(3):836-42.
2004: Shihou Murakami; Toshiyasu Sasaoka; Tsutomu Wada; Kazuhito Fukui; Kiyofumi Nagira; Hajime Ishihara; Isao Usui; Masashi Kobayashi
Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.
Endocrinology 2004;145(7):3215-23.
2001: Atsuko Takano; Tetsuro Haruta; Minoru Iwata; Isao Usui; T Uno; Junko Kawahara; E Ueno; Toshiyasu Sasaoka; Masashi Kobayashi
Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.
Diabetes 2001;50(8):1891-900.
2001: Akira Sato; Toshiyasu Sasaoka; Katsuya Yamazaki; Norio Nakamura; Rie Temaru; Manabu Ishiki; Masanobu Takata; Mika Kishida; Tsutomu Wada; Hajime Ishihara; Isao Usui; Masaharu Urakaze; Masashi Kobayashi
Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via phosphatidylinositol 3-kinase pathway in rat aortic smooth muscle cells.
Atherosclerosis 2001;157(2):341-52.
2001: Atsuko Takano; Isao Usui; Tetsuro Haruta; Junko Kawahara; T Uno; Minoru Iwata; Masashi Kobayashi
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
Molecular and cellular biology 2001;21(15):5050-62.
2001: E Ueno; Tetsuro Haruta; T Uno; Isao Usui; Minoru Iwata; Atsuko Takano; Junko Kawahara; Toshiyasu Sasaoka; O Ishibashi; Masashi Kobayashi
Potential role of Gab1 and phospholipase C-gamma in osmotic shock-induced glucose uptake in 3T3-L1 adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(7):402-6.
2001: Minoru Iwata; Tetsuro Haruta; Isao Usui; Yoshimi Takata; Atsuko Takano; T Uno; Junko Kawahara; E Ueno; Toshiyasu Sasaoka; O Ishibashi; Masashi Kobayashi
Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma.
Diabetes 2001;50(5):1083-92.
2000: Isao Usui; Tetsuro Haruta; Minoru Iwata; Atsuko Takano; T Uno; Junko Kawahara; E Ueno; Toshiyasu Sasaoka; Masashi Kobayashi
Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation.
Biochemical and biophysical research communications 2000;275(1):115-20.
1999: Isao Usui; Tetsuro Haruta; Yoshimi Takata; Minoru Iwata; T Uno; Atsuko Takano; E Ueno; O Ishibashi; Hajime Ishihara; Tsutomu Wada; Toshiyasu Sasaoka; Masashi Kobayashi
Differential effects of palmitate on glucose uptake in rat-1 fibroblasts and 3T3-L1 adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(10):546-52.
1999: Toshiyasu Sasaoka; Tsutomu Wada; Hajime Ishihara; Yoshimi Takata; Tetsuro Haruta; Isao Usui; Manabu Ishiki; Masashi Kobayashi
Synergistic role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking.
Endocrinology 1999;140(8):3826-34.
1998: Hajime Ishihara; Toshiyasu Sasaoka; Tsutomu Wada; Manabu Ishiki; Tetsuro Haruta; Isao Usui; Minoru Iwata; Atsuko Takano; T Uno; E Ueno; Masashi Kobayashi
Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors.
Biochemical and biophysical research communications 1998;252(1):139-44.
1998: T Imamura; Tetsuro Haruta; Yoshimi Takata; Isao Usui; Minoru Iwata; Hajime Ishihara; Manabu Ishiki; O Ishibashi; E Ueno; Toshiyasu Sasaoka; Masashi Kobayashi
Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome.
The Journal of biological chemistry 1998;273(18):11183-8.
1998: Isao Usui; Tetsuro Haruta; Masashi Kobayashi
[Anti insulin receptor antibody].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():51-4.
1997: Manabu Ishiki; Toshiyasu Sasaoka; Hajime Ishihara; T Imamura; Isao Usui; Yoshimi Takata; Masashi Kobayashi
Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors.
Endocrinology 1997;138(11):4950-8.
1997: Yoshimi Takata; T Imamura; Minoru Iwata; Isao Usui; Tetsuro Haruta; N Nandachi; Manabu Ishiki; Toshiyasu Sasaoka; Masashi Kobayashi
Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis.
Biochemical and biophysical research communications 1997;237(2):345-7.
1997: Isao Usui; Yoshimi Takata; T Imamura; H Morioka; Toshiyasu Sasaoka; T Sawa; Hajime Ishihara; Manabu Ishiki; Masashi Kobayashi
Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity.
Diabetologia 1997;40(8):894-901.
1997: Hajime Ishihara; Toshiyasu Sasaoka; Manabu Ishiki; Yoshimi Takata; T Imamura; Isao Usui; W J Langlois; T Sawa; Masashi Kobayashi
Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors.
The Journal of biological chemistry 1997;272(14):9581-6.
1996: Yoshimi Takata; T Imamura; Tetsuro Haruta; Toshiyasu Sasaoka; H Morioka; Hajime Ishihara; T Sawa; Isao Usui; Manabu Ishiki; Masashi Kobayashi
The dominant negative effect of a kinase-defective insulin receptor on insulin-like growth factor-I-stimulated signaling in Rat-1 fibroblasts.
Metabolism: clinical and experimental 1996;45(12):1474-82.
1996: Toshiyasu Sasaoka; Manabu Ishiki; T Sawa; Hajime Ishihara; Yoshimi Takata; T Imamura; Isao Usui; Jerrold M Olefsky; Masashi Kobayashi
Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.
Endocrinology 1996;137(10):4427-34.
1996: Toshiyasu Sasaoka; Hajime Ishihara; T Sawa; Manabu Ishiki; H Morioka; T Imamura; Isao Usui; Yoshimi Takata; Masashi Kobayashi
Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.
The Journal of biological chemistry 1996;271(33):20082-7.
1996: Y Takada; Yoshimi Takata; M Iwanishi; T Imamura; T Sawa; H Morioka; Hajime Ishihara; Manabu Ishiki; Isao Usui; Rie Temaru; Masaharu Urakaze; Y Satoh; T Inami; S Tsuda; Masashi Kobayashi
Effect of glimepiride (HOE 490) on insulin receptors of skeletal muscles from genetically diabetic KK-Ay mouse.
European journal of pharmacology 1996;308(2):205-10.
1996: T Sawa; T Imamura; Tetsuro Haruta; Toshiyasu Sasaoka; Manabu Ishiki; Yoshimi Takata; Y Takada; H Morioka; Hajime Ishihara; Isao Usui; Masashi Kobayashi
Hsp70 family molecular chaperones and mutant insulin receptor: differential binding specificities of BiP and Hsp70/Hsc70 determines accumulation or degradation of insulin receptor.
Biochemical and biophysical research communications 1996;218(2):449-53.