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Hideo Utsumi

Research Profile

Procedures

Electron Spin Resonance Spectroscopy

Chemicals & Drugs

Living Beings

Mouse
Rats

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Oxidation-Reduction

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Anatomy

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Lipid Peroxidation

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Publications

TOP 3
Nuttavut Kosem; Kazuhiro Ichikawa; Hideo Utsumi; Primchanien Moongkarndi
In vivo toxicity and antitumor activity of mangosteen extract.
Keiji Yasukawa; Hiroto Tokuda; Xin Tun; Hideo Utsumi; Ken-ichi Yamada
The detrimental effect of nitric oxide on tissue is associated with inflammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis.
Nuttavut Kosem; Tatsuya Naganuma; Noppawan Phumala Morales; Fuminori Hyodo; Kazuhiro Ichikawa; Ken-Ichi Yamada; Keiji Yasukawa; Hideo Utsumi
Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI.

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2013: Nuttavut Kosem; Kazuhiro Ichikawa; Hideo Utsumi; Primchanien Moongkarndi
In vivo toxicity and antitumor activity of mangosteen extract.
Journal of natural medicines 2013;67(2):255-63.
2012: Keiji Yasukawa; Hiroto Tokuda; Xin Tun; Hideo Utsumi; Ken-ichi Yamada
The detrimental effect of nitric oxide on tissue is associated with inflammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis.
Free radical research 2012;46(12):1427-36.
2012: Nuttavut Kosem; Tatsuya Naganuma; Noppawan Phumala Morales; Fuminori Hyodo; Kazuhiro Ichikawa; Ken-Ichi Yamada; Keiji Yasukawa; Hideo Utsumi
Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI.
Free radical biology & medicine 2012;53(2):328-36.
2012: Takahiro A Kato; Akira Monji; Sho Tsuboi; Hideo Utsumi; Motoki Watabe; Kazuhide Hashiya; Katsuhiko Ishikawa; Shigenobu Kanba
Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors.
PloS one 2012;7(7):e40461.
2012: Noppawan Phumala Morales; Kimiyo Murakami; Nuttavut Kosem; Yumiko Yamaguchi; Hideo Utsumi
Hepatic reduction of carbamoyl-PROXYL in ferric nitrilotriacetate induced iron overloaded mice: an in vivo ESR study.
Biological & pharmaceutical bulletin 2012;35(7):1035-40.
2012: Keisuke Shinohara; Yoshitaka Hirooka; Takuya Kishi; Kiyohiro Ogawa; Hideo Utsumi; Keiji Yasukawa; Kenji Sunagawa
Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2012;34(6):456-62.
2011: Hisato Deguchi; Kazuhiro Ichikawa; Yuichi Kinoshita; Fumiya Mito; Tatsuya Naganuma; Kiyoshi Sakai; Suguru Sato; Hideo Utsumi; Toshihide Yamasaki; Mayumi Yamato; Keiji Yasukawa; Ken-ichi Yamada
Nitroxides prevent exacerbation of indomethacin-induced gastric damage in adjuvant arthritis rats.
Free radical biology & medicine 2011;51(9):1799-805.
2011: Mayumi Yamato; Kazuhiro Ichikawa; Tatsuya Naganuma; Takeshi Shiba; Hideo Utsumi; Ken-ichi Yamada
Overhauser-enhanced magnetic resonance imaging characterization of mitochondria functional changes in the 6-hydroxydopamine rat model.
Neurochemistry international 2011;59(6):804-11.
2011: Takeshi Shiba; Hideo Utsumi; Toshiaki Watanabe; Wataru Kudo; Mayumi Yamato; Ken-ichi Yamada
In vivo imaging of mitochondrial function in methamphetamine-treated rats.
NeuroImage 2011;57(3):866-72.
2011: Takahiro A Kato; Yasutaka Maeda; Yoshito Mizoguchi; Akira Monji; Yoshihiro Seki; Noriyuki Sonoda; Hideo Utsumi; Keiji Yasukawa; Youn-Hee Han; Sadayuki Hashioka; Eiichi Hirata; Hideki Horikawa; Toyoshi Inoguchi; Mina Kasai; Shigenobu Kanba
Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia.
Schizophrenia research 2011;129(2-3):172-82.
2011: Fumiya Mito; Toshihide Yamasaki; Yuko Ito; Mayumi Yamato; Hiroyuki Mino; Hiromi Sadasue; Chisato Shirahama; Kiyoshi Sakai; Hideo Utsumi; Ken-ichi Yamada
Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical.
Chemical communications (Cambridge, England) 2011;47(17):5070-2.
2011: Toshihide Yamasaki; Fumiya Mito; Yuko Ito; Sokkar Pandian; Yuichi Kinoshita; Koji Nakano; Ramachandran Murugesan; Kiyoshi Sakai; Hideo Utsumi; Ken-ichi Yamada
Structure-reactivity relationship of piperidine nitroxide: electrochemical, ESR and computational studies.
The Journal of organic chemistry 2011;76(2):435-40.
2010: Daisuke Miura; Yoshinori Fujimura; Mayumi Yamato; Fuminori Hyodo; Hideo Utsumi; Hirofumi Tachibana; Hiroyuki Wariishi
Ultrahighly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors.
Analytical chemistry 2010;82(23):9789-96.
2010: Yuichi Kinoshita; Ken-ichi Yamada; Toshihide Yamasaki; Fumiya Mito; Mayumi Yamato; Nuttavut Kosem; Hisato Deguchi; Chisato Shirahama; Yuko Ito; Kana Kitagawa; Nobuhisa Okukado; Kiyoshi Sakai; Hideo Utsumi
In vivo evaluation of novel nitroxyl radicals with reduction stability.
Free radical biology & medicine 2010;49(11):1703-9.
2010: A Milton Franklin Benial; Hideo Utsumi; Kazuhiro Ichikawa; Ramachandran Murugesan; Ken-ichi Yamada; Yuichi Kinoshita; Tatsuya Naganuma; Masahisa Kato
Dynamic nuclear polarization studies of redox-sensitive nitroxyl spin probes in liposomal solution.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2010;204(1):131-8.
2010: Mayumi Yamato; Wataru Kudo; Takeshi Shiba; Ken-iichi Yamada; Toshiaki Watanabe; Hideo Utsumi
Determination of reactive oxygen species associated with the degeneration of dopaminergic neurons during dopamine metabolism.
Free radical research 2010;44(3):249-57.
2010: Sayo Kawai; Ken-Ichiro Matsumoto; Hideo Utsumi
An EPR method for estimating activity of antioxidants in mouse skin using an anthralin-derived radical model.
Free radical research 2010;44(3):267-74.
2009: Mayumi Yamato; Takeshi Shiba; Ken-ichi Yamada; Toshiaki Watanabe; Hideo Utsumi
Noninvasive assessment of the brain redox status after transient middle cerebral artery occlusion using Overhauser-enhanced magnetic resonance imaging.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(10):1655-64.
2009: Mayumi Yamato; Takeshi Shiba; Ken-Ichi Yamada; Toshiaki Watanabe; Hideo Utsumi
Separable detection of lipophilic- and hydrophilic-phase free radicals from the ESR spectrum of nitroxyl radical in transient MCAO mice.
Free radical research 2009;43(9):844-51.
2009: Yuichi Kinoshita; Ken-Ichi Yamada; Toshihide Yamasaki; Hiromi Sadasue; Kiyoshi Sakai; Hideo Utsumi
Development of novel nitroxyl radicals for controlling reactivity with ascorbic acid.
Free radical research 2009;43(6):565-71.
2009: Keiji Yasukawa; Reiko Miyakawa; Takashi Yao; Masazumi Tsuneyoshi; Hideo Utsumi
Non-invasive monitoring of redox status in mice with dextran sodium sulphate-induced colitis.
Free radical research 2009;43(5):505-13.
2009: Kazuhiro Ichikawa; Ken-Ichi Yamada; Keiji Yasukawa; Hideo Utsumi
[Analysis of in vivo redox status with magnetic resonance technique].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2009;129(3):273-8.
2009: Takahiro Inoue; Tomomi Ide; Mayumi Yamato; Masayoshi Yoshida; Takaki Tsutsumi; Makoto Andou; Hideo Utsumi; Hiroyuki Tsutsui; Kenji Sunagawa
Time-dependent changes of myocardial and systemic oxidative stress are dissociated after myocardial infarction.
Free radical research 2009;43(1):37-46.
2008: Ken-ichi Yamada; Yuichi Kinoshita; Toshihide Yamasaki; Hiromi Sadasue; Fumiya Mito; Mika Nagai; Shingo Matsumoto; Mariko Aso; Hiroshi Suemune; Kiyoshi Sakai; Hideo Utsumi
Synthesis of nitroxyl radicals for Overhauser-enhanced magnetic resonance imaging.
Archiv der Pharmazie 2008;341(9):548-53.
2008: Takeshi Shiba; Mayumi Yamato; Wataru Kudou; Kazuhiro Ichikawa; Ken-Ichi Yamada; Toshiaki Watanabe; Hideo Utsumi
Analysis of nitroxyl spin probes in mouse brain by X-band ESR with microdialysis technique.
Journal of pharmaceutical sciences 2008;97(9):4101-7.
2008: Wataru Kudo; Mayumi Yamato; Ken-Ichi Yamada; Yuichi Kinoshita; Takeshi Shiba; Toshiaki Watanabe; Hideo Utsumi
Formation of TEMPOL-hydroxylamine during reaction between TEMPOL and hydroxyl radical: HPLC/ECD study.
Free radical research 2008;42(5):505-12.
2008: Takaki Tsutsumi; Tomomi Ide; Mayumi Yamato; Makoto Andou; Takeshi Shiba; Hideo Utsumi; Kenji Sunagawa
Effect of anaesthesia-induced alterations in haemodynamics on in vivo kinetics of nitroxyl probes in electron spin resonance spectroscopy.
Free radical research 2008;42(4):305-11.
2008: Takaki Tsutsumi; Tomomi Ide; Mayumi Yamato; Wataru Kudou; Makoto Andou; Yoshitaka Hirooka; Hideo Utsumi; Hiroyuki Tsutsui; Kenji Sunagawa
Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction.
Cardiovascular research 2008;77(4):713-21.
2008: Satoshi Yasuda; Kenjiro Ikuta; Toyokazu Uwatoku; Keiji Oi; Kohtaro Abe; Fuminori Hyodo; Kengo Yoshimitsu; Kohtaro Sugimura; Hideo Utsumi; Yoshiki Katayama; Hiroaki Shimokawa
In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice.
Journal of vascular research 2008;45(2):123-8.
2007: Kazuhiro Ichikawa; Emiko Sakabe; Ken-Ichiro Kuninobu; Takao Yamori; Takashi Tsuruo; Takashi Yao; Masazumi Tsuneyoshi; Hideo Utsumi
Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad.
Antioxidants & redox signaling 2007;9(10):1699-707.
2007: Ryo Yamasaki; Jian Zhang; Ichiro Koshiishi; Dewi F Sastradipura Suniarti; Zhou Wu; Christoph Peters; Michael Schwake; Yasuo Uchiyama; Jun-ichi Kira; Paul Saftig; Hideo Utsumi; Hiroshi Nakanishi
Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.
Molecular and cellular neurosciences 2007;35(4):573-84.
2007: Shingo Matsumoto; Kenichi Yamada; Hiroshi Hirata; Keiji Yasukawa; Fuminori Hyodo; Kazuhiro Ichikawa; Hideo Utsumi
Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;57(4):806-11.
2007: Sadayuki Hashioka; Youn-Hee Han; Shunsuke Fujii; Takahiro Kato; Akira Monji; Hideo Utsumi; Makoto Sawada; Hiroshi Nakanishi; Shigenobu Kanba
Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation.
Free radical biology & medicine 2007;42(7):945-54.
2007: Mayumi Yamato; Shingo Matsumoto; Katsuaki Ura; Ken-Ichi Yamada; Tatsuya Naganuma; Toyoshi Inoguchi; Toshiaki Watanabe; Hideo Utsumi
Are free radical reactions increased in the diabetic eye?
Antioxidants & redox signaling 2007;9(3):367-73.
2007: Sadayuki Hashioka; Youn-Hee Han; Shunsuke Fujii; Takahiro Kato; Akira Monji; Hideo Utsumi; Makoto Sawada; Hiroshi Nakanishi; Shigenobu Kanba
Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia.
Neurochemistry international 2007;50(3):499-506.
2006: Fuminori Hyodo; Keiji Yasukawa; Ken-Ichi Yamada; Hideo Utsumi
Spatially resolved time-course studies of free radical reactions with an EPRI/MRI fusion technique.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;56(4):938-43.
2006: A Milton Franklin Benial; Kazuhiro Ichikawa; Ramachandran Murugesan; Ken-ichi Yamada; Hideo Utsumi
Dynamic nuclear polarization properties of nitroxyl radicals used in Overhauser-enhanced MRI for simultaneous molecular imaging.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;182(2):273-82.
2006: Ken-ichi Yamada; Ikuo Yamamiya; Hideo Utsumi
In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue.
Free radical biology & medicine 2006;40(11):2040-6.
2006: Ken-ichi Yamada; Toshitaka Nakamura; Hideo Utsumi
Enhanced intraarticular free radical reactions in adjuvant arthritis rats.
Free radical research 2006;40(5):455-60.
2006: Ken-ichiro Matsumoto; Sayo Kawai; Colin F Chignell; Hideo Utsumi
Location of anthralin radical generation in mouse skin by UV-A irradiation: an estimation using microscopic EPR spectral-spatial imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;55(4):738-42.
2006: Kazuhiro Ichikawa; Yasuko Sato; Hiroshi Kondo; Hideo Utsumi
An ESR contrast agent is transported to rat liver through organic anion transporter.
Free radical research 2006;40(4):403-8.
2006: Hideo Utsumi; Keiji Yasukawa; Tetsuhiro Soeda; Ken-ichi Yamada; Ryota Shigemi; Takashi Yao; Masazumi Tsuneyoshi
Noninvasive mapping of reactive oxygen species by in vivo electron spin resonance spectroscopy in indomethacin-induced gastric ulcers in rats.
The Journal of pharmacology and experimental therapeutics 2006;317(1):228-35.
2006: Hideo Utsumi; Ken-ichi Yamada; Kazuhiro Ichikawa; Kiyoshi Sakai; Yuichi Kinoshita; Shingo Matsumoto; Mika Nagai
Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14N- and 15N-labeled nitroxyl radicals.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1463-8.
2005: Hirohito Tsubouchi; Toyoshi Inoguchi; Toshiyo Sonta; Naoichi Sato; Naotaka Sekiguchi; Kunihisa Kobayashi; Hideki Sumimoto; Hideo Utsumi; Hajime Nawata
Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement.
Free radical biology & medicine 2005;39(4):444-52.
2005: Toshiyo Sonta; Toyoshi Inoguchi; Shingo Matsumoto; Keiji Yasukawa; Mieko Inuo; Hirohito Tsubouchi; Noriyuki Sonoda; Kunihisa Kobayashi; Hideo Utsumi; Hajime Nawata
In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type 1 receptor blocker.
Biochemical and biophysical research communications 2005;330(2):415-22.
2005: Ken-ichiro Matsumoto; Tomoaki Yahiro; Ken-ichi Yamada; Hideo Utsumi
In vivo EPR spectroscopic imaging for a liposomal drug delivery system.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;53(5):1158-65.
2004: Toshiyo Sonta; Toyoshi Inoguchi; Hirohito Tsubouchi; Naotaka Sekiguchi; Kunihisa Kobayashi; Shingo Matsumoto; Hideo Utsumi; Hajime Nawata
Evalution of oxidative stress in diabetic animals by in vivo electron spin resonance measurement--role of protein kinase C.
Diabetes research and clinical practice 2004;66 Suppl 1():S109-13.
2004: Toshiyo Sonta; Toyoshi Inoguchi; Hirohito Tsubouchi; Naotaka Sekiguchi; Kunihisa Kobayashi; Shingo Matsumoto; Hideo Utsumi; Hajime Nawata
Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity.
Free radical biology & medicine 2004;37(1):115-23.
2004: Tatsuhiro Yamamoto; Kenjiro Ikuta; Keiji Oi; Kohtaro Abe; Toyokazu Uwatoku; Fuminori Hyodo; Masaharu Murata; Noboru Shigetani; Kengo Yoshimitsu; Hiroaki Shimokawa; Hideo Utsumi; Yoshiki Katayama
In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.
Bioorganic & medicinal chemistry letters 2004;14(11):2787-90.
2004: Keizo Takeshita; Tokuko Takajo; Hiroshi Hirata; Mitsuhiro Ono; Hideo Utsumi
In vivo oxygen radical generation in the skin of the protoporphyria model mouse with visible light exposure: an L-band ESR study.
The Journal of investigative dermatology 2004;122(6):1463-70.
2004: Ken-Ichi Yamada; Daisuke Inoue; Shingo Matsumoto; Hideo Utsumi
In vivo measurement of redox status in streptozotocin-induced diabetic rat using targeted nitroxyl probes.
Antioxidants & redox signaling 2004;6(3):605-11.
2004: Tetsuya Shiomi; Hiroyuki Tsutsui; Hidenori Matsusaka; Kimiyo Murakami; Shunji Hayashidani; Masaki Ikeuchi; Jing Wen; Toru Kubota; Hideo Utsumi; Akira Takeshita
Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice.
Circulation 2004;109(4):544-9.
2004: Keiji Yasukawa; Keiko Kasazaki; Fuminori Hyodo; Hideo Utsumi
Non-invasive analysis of reactive oxygen species generated in rats with water immersion restraint-induced gastric lesions using in vivo electron spin resonance spectroscopy.
Free radical research 2004;38(2):147-55.
2004: Tetsuro Ago; Takanari Kitazono; Hiroaki Ooboshi; Teruaki Iyama; Youn Hee Han; Junichi Takada; Masanori Wakisaka; Setsuro Ibayashi; Hideo Utsumi; Mitsuo Iida
Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase.
Circulation 2004;109(2):227-33.
2004: Youn-Hee Han; Kazuhiro Ichikawa; Hideo Utsumi
A kinetic study of enhancing effect by phenolic compounds on the hydroxyl radical generation during ozonation.
Water science and technology : a journal of the International Association on Water Pollution Research 2004;50(8):97-102.
2003: Mayumi Yamato; Toru Egashira; Hideo Utsumi
Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke.
Free radical biology & medicine 2003;35(12):1619-31.
2003: Hideo Utsumi; Youn-Hee Han; Kazuhiro Ichikawa
A kinetic study of 3-chlorophenol enhanced hydroxyl radical generation during ozonation.
Water research 2003;37(20):4924-8.
2003: Toyoshi Inoguchi; Hirohito Tsubouchi; Takashi Etoh; Maiko Kakimoto; Toshiyo Sonta; Hideo Utsumi; Hideki Sumimoto; Hai Yan Yu; Noriyuki Sonoda; Mieko Inuo; Naoichi Sato; Naotaka Sekiguchi; Kunihisa Kobayashi; Hajime Nawata
A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase.
Current medicinal chemistry 2003;10(17):1759-64.
2003: Toyoshi Inoguchi; Toshiyo Sonta; Hirohito Tsubouchi; Takashi Etoh; Maiko Kakimoto; Noriyuki Sonoda; Naoichi Sato; Naotaka Sekiguchi; Kunihisa Kobayashi; Hideki Sumimoto; Hideo Utsumi; Hajime Nawata
Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase.
Journal of the American Society of Nephrology : JASN 2003;14(8 Suppl 3):S227-32.
2003: Hideo Utsumi; Ken-ichi Yamada
In vivo electron spin resonance-computed tomography/nitroxyl probe technique for non-invasive analysis of oxidative injuries.
Archives of biochemistry and biophysics 2003;416(1):1-8.
2003: Shingo Matsumoto; Ichiro Koshiishi; Toyoshi Inoguchi; Hajime Nawata; Hideo Utsumi
Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice.
Free radical research 2003;37(7):767-72.
2003: Keiko Kasazaki; Keiji Yasukawa; Hiroaki Sano; Hideo Utsumi
Non-invasive analysis of reactive oxygen species generated in NH4OH-induced gastric lesions of rats using a 300 MHz in vivo ESR technique.
Free radical research 2003;37(7):757-66.
2003: Yukiko Yonekura; Ichiro Koshiishi; Ken-ichi Yamada; Akiko Mori; Soshi Uchida; Toshitaka Nakamura; Hideo Utsumi
Association between the expression of inducible nitric oxide synthase by chondrocytes and its nitric oxide-generating activity in adjuvant arthritis in rats.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;8(3):164-9.
2003: Yoji Machida; Toru Kubota; Natsumi Kawamura; Hajime Funakoshi; Tomomi Ide; Hideo Utsumi; Yun You Li; Arthur M Feldman; Hiroyuki Tsutsui; Hiroaki Shimokawa; Akira Takeshita
Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.
American journal of physiology. Heart and circulatory physiology 2003;284(2):H449-55.
2002: Ryo Nakamura; Kensuke Egashira; Youji Machida; Shunji Hayashidani; Motohiro Takeya; Hideo Utsumi; Hiroyuki Tsutsui; Akira Takeshita
Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: roles of oxidative stress and inflammation.
Circulation 2002;106(3):362-7.
2002: Akira Monji; Hideo Utsumi; Tadashi Ueda; Taiji Imoto; Ichiro Yoshida; Sadayuki Hashioka; Ken-ichiro Tashiro; Nobutada Tashiro
Amyloid-beta-protein (A beta) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides.
Life sciences 2002;70(7):833-41.
2002: S H Kim; Kazuhiro Ichikawa; Ichiro Koshiishi; Hideo Utsumi
Development of rapid in vitro assay for oxidative liver injury and its application to 230 chemicals.
Water science and technology : a journal of the International Association on Water Pollution Research 2002;46(11-12):337-41.
2002: Hideo Utsumi; Hiroaki Sano; Masaichi Naruse; Ken-ichiro Matsumoto; Kazuhiro Ichikawa; Tetsuo Oi
Nitroxyl probes for brain research and their application to brain imaging.
Methods in enzymology 2002;352():494-506.
2001: Hiroyuki Tsutsui; Tomomi Ide; Tetsuya Shiomi; Dongchon Kang; Shunji Hayashidani; Nobuhiro Suematsu; Jing Wen; Hideo Utsumi; Naotaka Hamasaki; Akira Takeshita
8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts.
Circulation 2001;104(24):2883-5.
2001: Hiroyuki Tsutsui; Tomomi Ide; Shunji Hayashidani; Nobuhiro Suematsu; Tetsuya Shiomi; Jing Wen; Kazuhiro Ichikawa; Hideo Utsumi; Akira Takeshita
Enhanced generation of reactive oxygen species in the limb skeletal muscles from a murine infarct model of heart failure.
Circulation 2001;104(2):134-6.
2001: Akira Monji; Hideo Utsumi; T Ueda; Taiji Imoto; Ichiro Yoshida; Sadayuki Hashioka; K Tashiro ; Nobutada Tashiro
The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides.
Journal of neurochemistry 2001;77(6):1425-32.
2001: Hiroyuki Tsutsui; Tomomi Ide; Shunji Hayashidani; Shintaro Kinugawa; Nobuhiro Suematsu; Hideo Utsumi; Akira Takeshita
Effects of ACE inhibition on left ventricular failure and oxidative stress in Dahl salt-sensitive rats.
Journal of cardiovascular pharmacology 2001;37(6):725-33.
2001: Akira Monji; Hideo Utsumi; Ichiro Yoshida; Sadayuki Hashioka; Ken-ichiro Tashiro; Nobutada Tashiro
The relationship between Abeta-associated free radical generation and Abeta fibril formation revealed by negative stain electron microscopy and thioflavine-T fluorometric assay.
Neuroscience letters 2001;304(1-2):65-8.
2001: Tomomi Ide; Hiroyuki Tsutsui; Shunji Hayashidani; Dongchon Kang; Nobuhiro Suematsu; K Nakamura; Hideo Utsumi; Naotaka Hamasaki; Akira Takeshita
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction.
Circulation research 2001;88(5):529-35.
2001: J Y Han; Keizo Takeshita; Hideo Utsumi
Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles.
Free radical biology & medicine 2001;30(5):516-25.
2001: Hiroyuki Tsutsui; Tomomi Ide; Shunji Hayashidani; Nobuhiro Suematsu; Hideo Utsumi; R Nakamura; Kensuke Egashira; Akira Takeshita
Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury.
Cardiovascular research 2001;49(1):103-9.
2000: Ken-ichiro Matsumoto; Hideo Utsumi
Development of separable electron spin resonance-computed tomography imaging for multiple radical species: an application to .OH and .NO.
Biophysical journal 2000;79(6):3341-9.
2000: Toyoshi Inoguchi; P Li; Fumio Umeda; Hai Yan Yu; Maiko Kakimoto; Minako Imamura; T Aoki; Takashi Etoh; Toshihiko Hashimoto; M Naruse; H Sano; Hideo Utsumi; Hajime Nawata
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.
Diabetes 2000;49(11):1939-45.
2000: Shintaro Kinugawa; Hiroyuki Tsutsui; Shunji Hayashidani; Tomomi Ide; Nobuhiro Suematsu; S Satoh; Hideo Utsumi; Akira Takeshita
Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress.
Circulation research 2000;87(5):392-8.
2000: H Sano; M Naruse; Ken-ichiro Matsumoto; T Oi; Hideo Utsumi
A new nitroxyl-probe with high retention in the brain and its application for brain imaging.
Free radical biology & medicine 2000;28(6):959-69.
2000: Tomomi Ide; Hiroyuki Tsutsui; Shintaro Kinugawa; Nobuhiro Suematsu; Shunji Hayashidani; Kazuhiro Ichikawa; Hideo Utsumi; Yoji Machida; Kensuke Egashira; Akira Takeshita
Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium.
Circulation research 2000;86(2):152-7.
1999: Tomomi Ide; Hiroyuki Tsutsui; Shintaro Kinugawa; Hideo Utsumi; Dongchon Kang; N Hattori; K Uchida; K i Arimura; Kensuke Egashira; Akira Takeshita
Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium.
Circulation research 1999;85(4):357-63.
1999: Tomomi Ide; Hiroyuki Tsutsui; Shintaro Kinugawa; Hideo Utsumi; Akira Takeshita
Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action.
Circulation 1999;100(7):690-2.
1999: H Sano; Hideo Utsumi
[Non-invasive measurement of in vivo free radical reactions].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114(2):107-13.
1999: N Phumala; Tomomi Ide; Hideo Utsumi
Noninvasive evaluation of in vivo free radical reactions catalyzed by iron using in vivo ESR spectroscopy.
Free radical biology & medicine 1999;26(9-10):1209-17.
1999: Keizo Takeshita; A Hamada; Hideo Utsumi
Mechanisms related to reduction of radical in mouse lung using an L-band ESR spectrometer.
Free radical biology & medicine 1999;26(7-8):951-60.
1998: T Sano; Fumio Umeda; Toshihiko Hashimoto; Hajime Nawata; Hideo Utsumi
Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes.
Diabetologia 1998;41(11):1355-60.
1997: H Sano; Ken-ichiro Matsumoto; Hideo Utsumi
Synthesis and imaging of blood-brain-barrier permeable nitroxyl-probes for free radical reactions in brain of living mice.
Biochemistry and molecular biology international 1997;42(3):641-7.