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Mathew Vadas

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Paul R Coleman; Christopher N Hahn; Matthew Grimshaw; Ying Lu; Xiaochun Li; Peter J Brautigan; Konstanze Beck; Roland Stocker; Mathew A Vadas; Jennifer R Gamble
Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.
Samantha L Williams; Ian R Milne; Christopher J Bagley; Jennifer R Gamble; Mathew A Vadas; Stuart M Pitson; Yeesim Khew-Goodall
A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration.
Jennifer R Gamble; Wai Y Sun; Xiaochun Li; Christopher N Hahn; Stuart M Pitson; Mathew A Vadas; Claudine S Bonder
Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival.

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2010: Paul R Coleman; Christopher N Hahn; Matthew Grimshaw; Ying Lu; Xiaochun Li; Peter J Brautigan; Konstanze Beck; Roland Stocker; Mathew A Vadas; Jennifer R Gamble
Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.
Blood 2010;116(19):4016-24.
2010: Samantha L Williams; Ian R Milne; Christopher J Bagley; Jennifer R Gamble; Mathew A Vadas; Stuart M Pitson; Yeesim Khew-Goodall
A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):3057-63.
2009: Jennifer R Gamble; Wai Y Sun; Xiaochun Li; Christopher N Hahn; Stuart M Pitson; Mathew A Vadas; Claudine S Bonder
Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival.
The American journal of pathology 2009;175(5):2217-25.
2009: Olga Sukocheva; Lijun Wang; Emily Verrier; Mathew A Vadas; Pu Xia
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway.
Endocrinology 2009;150(10):4484-92.
2009: Xiaochun Li; Milena Stankovic; Boris P-L Lee; michel AURRAND-LIONS; Chris N Hahn; Ying Lu; Beat A Imhof; Mathew A Vadas; Jennifer R Gamble
JAM-C induces endothelial cell permeability through its association and regulation of {beta}3 integrins.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(8):1200-6.
2009: Julia R Zebol; Niamh M Hewitt; Paul A B Moretti; Helen E Lynn; Julie A Lake; Peng Li; Mathew A Vadas; Binks W Wattenberg; Stuart M Pitson
The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.
The international journal of biochemistry & cell biology 2009;41(4):822-7.
2009: Claudine S Bonder; Wai Y Sun; Tyson Matthews; Carlos Cassano; Xiaochun Li; Hayley S Ramshaw; Stuart M Pitson; Angel F Lopez; P Toby Coates; Richard L Proia; Mathew A Vadas; Jennifer R Gamble
Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation.
Blood 2009;113(9):2108-17.
2009: Jennifer R Gamble; Mathew A Vadas
Insights into defibrotide as therapy for veno-occlusive disease.
Hepatology (Baltimore, Md.) 2009;49(2):689-90.
2009: Vidya Limaye; Mathew A Vadas; Stuart M Pitson; Jennifer R Gamble
The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells.
Cellular & molecular biology letters 2009;14(3):411-23.
2009: Vidya Limaye; Pu Xia; Chris Hahn; Malcolm Smith; Mathew A Vadas; Stuart M Pitson; Jennifer R Gamble
Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells.
Cellular & molecular biology letters 2009;14(3):424-41.
2008: Philip A Gregory; Andrew G Bert; Emily L Paterson; Simon C Barry; Anna Tsykin; Gelareh Farshid; Mathew A Vadas; Yeesim Khew-Goodall; Gregory J Goodall
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Nature cell biology 2008;10(5):593-601.
2008: Tamara M Leclercq; Paul A B Moretti; Mathew A Vadas; Stuart M Pitson
Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.
The Journal of biological chemistry 2008;283(15):9606-14.
2008: Xiaochun Li; Milena Stankovic; Claudine S Bonder; Chris Hahn; Michelle Parsons; Stuart M Pitson; Pu Xia; Richard L Proia; Mathew A Vadas; Jennifer R Gamble
Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1.
Blood 2008;111(7):3489-97.
2006: Pravin Hissaria; William Smith; Peter-John Wormald; James Taylor; Mathew A Vadas; David Gillis; Frank E Kette
Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures.
The Journal of allergy and clinical immunology 2006;118(1):128-33.
2006: Andrew G Bert; Renaud Grépin; Mathew A Vadas; Gregory J Goodall
Assessing IRES activity in the HIF-1alpha and other cellular 5' UTRs.
RNA (New York, N.Y.) 2006;12(6):1074-83.
2006: Jennifer R Gamble; Pu Xia; Chris Hahn; Jenny J Drew; Christopher J Drogemuller; David Brown; Mathew A Vadas
Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects.
International journal of cancer. Journal international du cancer 2006;118(10):2412-20.
2006: Catherine M Sutherland; Paul A B Moretti; Niamh M Hewitt; Christopher J Bagley; Mathew A Vadas; Stuart M Pitson
The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane.
The Journal of biological chemistry 2006;281(17):11693-701.
2006: Olga A Sukocheva; Carol Wadham; Andrew Holmes; Nathaniel Albanese; Emily Verrier; Feng Feng; Alex Bernal; Claudia K Derian; Axel Ullrich; Mathew A Vadas; Pu Xia
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.
The Journal of cell biology 2006;173(2):301-10.
2005: Lijun Wang; Xiao-Ping Xing; Andrew Holmes; Carol Wadham; Jennifer R Gamble; Mathew A Vadas; Pu Xia
Activation of the sphingosine kinase-signaling pathway by high glucose mediates the proinflammatory phenotype of endothelial cells.
Circulation research 2005;97(9):891-9.
2005: Leeanne S Coles; Lidia Lambrusco; Julie Burrows; Julie Hunter; Peter Diamond; Andrew G Bert; Mathew A Vadas; Gregory J Goodall
Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3beta and repression of the human VEGF promoter.
FEBS letters 2005;579(24):5372-8.
2005: Chris Hahn; Z J Su; C J Drogemuller; Anna Tsykin; S R Waterman; P J Brautigan; S Yu; Gabriel Kremmidiotis; Alison Gardner; Patty J Solomon; Gregory J Goodall; Mathew A Vadas; Jennifer R Gamble
Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis.
Physiological genomics 2005;22(1):57-69.
2005: Vidya Limaye; Xiaochun Li; Chris Hahn; Pu Xia; Michael C Berndt; Mathew A Vadas; Jennifer R Gamble
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members.
Blood 2005;105(8):3169-77.
2005: Stuart M Pitson; Pu Xia; Tamara M Leclercq; Paul A B Moretti; Julia R Zebol; Helen E Lynn; Binks W Wattenberg; Mathew A Vadas
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling.
The Journal of experimental medicine 2005;201(1):49-54.
2004: Xiaochun Li; Chris Hahn; Michelle Parsons; Jenny J Drew; Mathew A Vadas; Jennifer R Gamble
Role of protein kinase Czeta in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1.
Blood 2004;104(6):1716-24.
2004: Zhi-Jian Su; Chris Hahn; Gregory J Goodall; Niamh M Reck; Annabell F Leske; Ann Davy; Gabriel Kremmidiotis; Mathew A Vadas; Jennifer R Gamble
A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12212-7.
2004: Jane L Roberts; Paul A B Moretti; Andrew L Darrow; Claudia K Derian; Mathew A Vadas; Stuart M Pitson
An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes.
Analytical biochemistry 2004;331(1):122-9.
2004: Emily Verrier; Lijun Wang; Carol Wadham; Nathaniel Albanese; Chris Hahn; Jennifer R Gamble; V Krishna K Chatterjee; Mathew A Vadas; Pu Xia
PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase.
Circulation research 2004;94(11):1515-22.
2004: Carol Wadham; Nathaniel Albanese; Jane Roberts; Lijun Wang; Christopher J Bagley; Jennifer R Gamble; Kerry-Anne Rye; Philip J Barter; Mathew A Vadas; Pu Xia
High-density lipoproteins neutralize C-reactive protein proinflammatory activity.
Circulation 2004;109(17):2116-22.
2004: Leeanne S Coles; M Antonetta Bartley; Andrew G Bert; Julie Hunter; Steven Polyak; Peter Diamond; Mathew A Vadas; Gregory J Goodall
A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization.
European journal of biochemistry / FEBS 2004;271(3):648-60.
2003: brian stein; Jennifer R Gamble; Stuart M Pitson; Mathew A Vadas; Yeesim Khew-Goodall
Activation of endothelial extracellular signal-regulated kinase is essential for neutrophil transmigration: potential involvement of a soluble neutrophil factor in endothelial activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6097-104.
2003: Stuart M Pitson; Paul A B Moretti; Julia R Zebol; Helen E Lynn; Pu Xia; Mathew A Vadas; Binks W Wattenberg
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation.
The EMBO journal 2003;22(20):5491-500.
2003: Beat A Imhof; Mathew A Vadas
New therapeutic targets in vascular biology.
Thrombosis and haemostasis 2003;90(4):557-9.
2003: Olga A Sukocheva; Lijun Wang; Nathaniel Albanese; Stuart M Pitson; Mathew A Vadas; Pu Xia
Sphingosine kinase transmits estrogen signaling in human breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2003;17(10):2002-12.
2003: Carol Wadham; Jennifer R Gamble; Mathew A Vadas; Yeesim Khew-Goodall
The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.
Molecular biology of the cell 2003;14(6):2520-9.
2002: Stuart M Pitson; Paul A B Moretti; Julia R Zebol; Reza Zareie; Claudia K Derian; Andrew L Darrow; Jenson Qi; Richard J D'Andrea; Christopher J Bagley; Mathew A Vadas; Binks W Wattenberg
The nucleotide-binding site of human sphingosine kinase 1.
The Journal of biological chemistry 2002;277(51):49545-53.
2002: Leeanne S Coles; Peter Diamond; Lidia Lambrusco; Julie Hunter; Julie Burrows; Mathew A Vadas; Gregory J Goodall
A novel mechanism of repression of the vascular endothelial growth factor promoter, by single strand DNA binding cold shock domain (Y-box) proteins in normoxic fibroblasts.
Nucleic acids research 2002;30(22):4845-54.
2002: Abbas Hawwari; Julie Burrows; Mathew A Vadas; Peter N Cockerill
The human IL-3 locus is regulated cooperatively by two NFAT-dependent enhancers that have distinct tissue-specific activities.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):1876-86.
2002: Pu Xia; Lijun Wang; Paul A B Moretti; Nathaniel Albanese; Fugui Chai; Stuart M Pitson; Richard J D'Andrea; Jennifer R Gamble; Mathew A Vadas
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.
The Journal of biological chemistry 2002;277(10):7996-8003.
2001: Stuart M Pitson; Paul A B Moretti; Julia R Zebol; Mathew A Vadas; Richard J D'Andrea; Binks W Wattenberg
A point mutant of human sphingosine kinase 1 with increased catalytic activity.
FEBS letters 2001;509(2):169-73.
2001: M A Clay; DH Pyle; Kerry-Anne Rye; Mathew A Vadas; Jennifer R Gamble; P J Barter
Time sequence of the inhibition of endothelial adhesion molecule expression by reconstituted high density lipoproteins.
Atherosclerosis 2001;157(1):23-9.
2001: K L Jones; Christopher J Bagley; Carolyn M Butcher; S C Barry; Mathew A Vadas; Richard J D'Andrea
Peptide insertions in domain 4 of hbeta(c), the shared signalling receptor subunit for GM-CSF, IL3 and IL5, induce ligand-independent activation.
Cytokine 2001;14(6):303-15.
2001: JA Dibbens; S W Polyak; Annette Damert; Werner Risau; Mathew A Vadas; Gregory J Goodall
Nucleotide sequence of the mouse VEGF 3'UTR and quantitative analysis of sites of polyadenylation.
Biochimica et biophysica acta 2001;1518(1-2):57-62.
2001: Peter Diamond; M Frances Shannon; Mathew A Vadas; Leeanne S Coles
Cold shock domain factors activate the granulocyte-macrophage colony-stimulating factor promoter in stimulated Jurkat T cells.
The Journal of biological chemistry 2001;276(11):7943-51.
2001: D Ashby; J Gamble; Mathew A Vadas; N Fidge; S Siggins; Kerry-Anne Rye; Philip J Barter
Lack of effect of serum amyloid A (SAA) on the ability of high-density lipoproteins to inhibit endothelial cell adhesion molecule expression.
Atherosclerosis 2001;154(1):113-21.
2000: Pu Xia; Jennifer R Gamble; Lijun Wang; Stuart M Pitson; Paul A B Moretti; Binks W Wattenberg; Richard J D'Andrea; Mathew A Vadas
An oncogenic role of sphingosine kinase.
Current biology : CB 2000;10(23):1527-30.
2000: Andrew G Bert; Julie Burrows; Abbas Hawwari; Mathew A Vadas; Peter N Cockerill
Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5646-55.
2000: Stuart M Pitson; Paul A B Moretti; Julia R Zebol; Pu Xia; Jennifer R Gamble; Mathew A Vadas; Richard J D'Andrea; Binks W Wattenberg
Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase.
The Journal of biological chemistry 2000;275(43):33945-50.
2000: Jennifer R Gamble; Jenny J Drew; L Trezise; A Underwood; M Parsons; L Kasminkas; J Rudge; G Yancopoulos; Mathew A Vadas
Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions.
Circulation research 2000;87(7):603-7.
2000: Stuart M Pitson; Richard J D'Andrea; L Vandeleur; Paul A B Moretti; Pu Xia; Jennifer R Gamble; Mathew A Vadas; Binks W Wattenberg
Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes.
The Biochemical journal 2000;350 Pt 2():429-41.
2000: Carol Wadham; Jennifer R Gamble; Mathew A Vadas; Yeesim Khew-Goodall
Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation.
Journal of cell science 2000;113 ( Pt 17)():3117-23.
2000: Paul W Baker; Kerry-Anne Rye; Jennifer R Gamble; Mathew A Vadas; Philip J Barter
Phospholipid composition of reconstituted high density lipoproteins influences their ability to inhibit endothelial cell adhesion molecule expression.
Journal of lipid research 2000;41(8):1261-7.
2000: Leeanne S Coles; Peter Diamond; F Occhiodoro; Mathew A Vadas; M Frances Shannon
An ordered array of cold shock domain repressor elements across tumor necrosis factor-responsive elements of the granulocyte-macrophage colony-stimulating factor promoter.
The Journal of biological chemistry 2000;275(19):14482-93.
2000: Terrence D Mulhern; Angel F Lopez; Richard J D'Andrea; C Gaunt; L Vandeleur; Mathew A Vadas; Grant W Booker; Christopher J Bagley
The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5.
Journal of molecular biology 2000;297(4):989-1001.
1999: Peter N Cockerill; Andrew G Bert; D Roberts; Mathew A Vadas
The human granulocyte-macrophage colony-stimulating factor gene is autonomously regulated in vivo by an inducible tissue-specific enhancer.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15097-102.
1999: Pu Xia; Lijun Wang; Jennifer R Gamble; Mathew A Vadas
Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells.
The Journal of biological chemistry 1999;274(48):34499-505.
1999: Pu Xia; Mathew A Vadas; Kerry-Anne Rye; Philip J Barter; Jennifer R Gamble
High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL.
The Journal of biological chemistry 1999;274(46):33143-7.
1999: Terrence D Mulhern; Christopher J Bagley; C Gaunt; Angel F Lopez; Mathew A Vadas; Richard J D'Andrea; Grant W Booker
1H and 15N chemical shift assignments for domain 4 of the common beta-chain of the IL-3, IL-5 and GM-CSF receptors.
Journal of biomolecular NMR 1999;14(3):281-2.
1999: Yeesim Khew-Goodall; Carol Wadham; brian stein; Jennifer R Gamble; Mathew A Vadas
Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(6):1421-9.
1999: K Hiki; Richard J D'Andrea; J Furze; J Crawford; Erica Woollatt; Grant R Sutherland; Mathew A Vadas; Jennifer R Gamble
Cloning, characterization, and chromosomal location of a novel human K+-Cl- cotransporter.
The Journal of biological chemistry 1999;274(15):10661-7.
1999: JA Dibbens; D L Miller; Annette Damert; Werner Risau; Mathew A Vadas; Gregory J Goodall
Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements.
Molecular biology of the cell 1999;10(4):907-19.
1999: Paul W Baker; Kerry-Anne Rye; Jennifer R Gamble; Mathew A Vadas; Philip J Barter
Ability of reconstituted high density lipoproteins to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells.
Journal of lipid research 1999;40(2):345-53.
1999: J Gamble; G Meyer; L Noack; J Furze; L Matthias; N Kovach; J Harlant; Mathew A Vadas
B1 integrin activation inhibits in vitro tube formation: effects on cell migration, vacuole coalescence and lumen formation.
Endothelium : journal of endothelial cell research 1999;7(1):23-34.
1998: Richard J D'Andrea; D Harrison-Findik; Carolyn M Butcher; John W Finnie; P Blumbergs; Paul A Bartley; MP McCormack; K Jones; R Rowland; Thomas J Gonda; Mathew A Vadas
Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common beta chain in transgenic mice.
The Journal of clinical investigation 1998;102(11):1951-60.
1998: Pu Xia; Jennifer R Gamble; Kerry-Anne Rye; Lijun Wang; Charles S T Hii; Peter N Cockerill; Yeesim Khew-Goodall; Andrew G Bert; Philip J Barter; Mathew A Vadas
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14196-201.
1998: C T Hua; Jennifer R Gamble; Mathew A Vadas; D E Jackson
Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates.
The Journal of biological chemistry 1998;273(43):28332-40.
1998: D L Miller; JA Dibbens; Annette Damert; Werner Risau; Mathew A Vadas; Gregory J Goodall
The vascular endothelial growth factor mRNA contains an internal ribosome entry site.
FEBS letters 1998;434(3):417-20.
1998: D T Ashby; Kerry-Anne Rye; M A Clay; Mathew A Vadas; Jennifer R Gamble; P J Barter
Factors influencing the ability of HDL to inhibit expression of vascular cell adhesion molecule-1 in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(9):1450-5.
1998: S Isenmann; Y Khew-Goodall; J Gamble; Mathew A Vadas; Binks W Wattenberg
A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal.
Molecular biology of the cell 1998;9(7):1649-60.
1997: M Litwin; K Clark; L Noack; J Furze; M Berndt; S Albelda; Mathew A Vadas; J Gamble
Novel cytokine-independent induction of endothelial adhesion molecules regulated by platelet/endothelial cell adhesion molecule (CD31).
The Journal of cell biology 1997;139(1):219-28.
1997: Christopher J Bagley; Angel F Lopez; Mathew A Vadas
New frontiers for IL-5.
The Journal of allergy and clinical immunology 1997;99(6 Pt 1):725-8.
1997: Mathew A Vadas; Jennifer R Gamble; Kerry-Anne Rye; P Barter
Regulation of leucocyte-endothelial interactions of special relevance to atherogenesis.
Clinical and experimental pharmacology & physiology 1997;24(5):A33-5.
1997: K N Duncliffe; Andrew G Bert; Mathew A Vadas; Peter N Cockerill
A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site.
Immunity 1997;6(2):175-85.
1997: S C Barry; E Korpelainen; Q Sun; Frank C Stomski; Paul A B Moretti; H Wakao; Richard J D'Andrea; Mathew A Vadas; Angel F Lopez; Gregory J Goodall
Roles of the N and C terminal domains of the interleukin-3 receptor alpha chain in receptor function.
Blood 1997;89(3):842-52.
1997: M Frances Shannon; Leeanne S Coles; Mathew A Vadas; Peter N Cockerill
Signals for activation of the GM-CSF promoter and enhancer in T cells.
Critical reviews in immunology 1997;17(3-4):301-23.
1996: Christopher J Bagley; J Phillips; B Cambareri; Mathew A Vadas; Angel F Lopez
A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor.
The Journal of biological chemistry 1996;271(50):31922-8.
1996: C Y Brown; C A Lagnado; Mathew A Vadas; G J Goodall
Differential regulation of the stability of cytokine mRNAs in lipopolysaccharide-activated blood monocytes in response to interleukin-10.
The Journal of biological chemistry 1996;271(33):20108-12.
1996: W B Smith; L Noack; Yeesim Khew-Goodall; S Isenmann; Mathew A Vadas; Jennifer R Gamble
Transforming growth factor-beta 1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):360-8.
1996: L S Coles; P Diamond; F Occhiodoro; Mathew A Vadas; M Frances Shannon
Cold shock domain proteins repress transcription from the GM-CSF promoter.
Nucleic acids research 1996;24(12):2311-7.
1996: Richard J D'Andrea; S C Barry; P A Moretti; K Jones; S Ellis; Mathew A Vadas; G J Goodall
Extracellular truncations of h beta c, the common signaling subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5, lead to ligand-independent activation.
Blood 1996;87(7):2641-8.
1996: Yeesim Khew-Goodall; C M Butcher; M S Litwin; S Newlands; E I Korpelainen; L M Noack; M C Berndt; Angel F Lopez; Jennifer R Gamble; Mathew A Vadas
Chronic expression of P-selectin on endothelial cells stimulated by the T-cell cytokine, interleukin-3.
Blood 1996;87(4):1432-8.
1996: E I Korpelainen; Jennifer R Gamble; Mathew A Vadas; Angel F Lopez
IL-3 receptor expression, regulation and function in cells of the vasculature.
Immunology and cell biology 1996;74(1):1-7.
1996: Q Sun; Joanna M Woodcock; Aaron P Rapoport; Frank C Stomski; E I Korpelainen; Christopher J Bagley; G J Goodall; W B Smith; Jennifer R Gamble; Mathew A Vadas; Angel F Lopez
Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.
Blood 1996;87(1):83-92.
1995: W B Smith; L Guida; Q Sun; E I Korpelainen; C van den Heuvel; D Gillis; C M Hawrylowicz; Mathew A Vadas; Angel F Lopez
Neutrophils activated by granulocyte-macrophage colony-stimulating factor express receptors for interleukin-3 which mediate class II expression.
Blood 1995;86(10):3938-44.
1995: G W Cockerill; Kerry-Anne Rye; Jennifer R Gamble; Mathew A Vadas; P J Barter
High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(11):1987-94.
1995: G W Cockerill; Andrew G Bert; G R Ryan; Jennifer R Gamble; Mathew A Vadas; Peter N Cockerill
Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT.
Blood 1995;86(7):2689-98.
1995: C S Osborne; Mathew A Vadas; Peter N Cockerill
Transcriptional regulation of mouse granulocyte-macrophage colony-stimulating factor/IL-3 locus.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):226-35.
1995: Jennifer R Gamble; S Bradley; L Noack; Mathew A Vadas
TGF-beta and endothelial cells inhibit VCAM-1 expression on human vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(7):949-55.
1995: E I Korpelainen; Jennifer R Gamble; W B Smith; M Dottore; Mathew A Vadas; Angel F Lopez
Interferon-gamma upregulates interleukin-3 (IL-3) receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production.
Blood 1995;86(1):176-82.
1995: D Cooper; F P Lindberg; J R Gamble; E J Brown; Mathew A Vadas
Transendothelial migration of neutrophils involves integrin-associated protein (CD47).
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3978-82.
1995: Peter N Cockerill; Andrew G Bert; F Jenkins; G R Ryan; M Frances Shannon; Mathew A Vadas
Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c.
Molecular and cellular biology 1995;15(4):2071-9.
1995: G W Cockerill; Jennifer R Gamble; Mathew A Vadas
Angiogenesis: models and modulators.
International review of cytology 1995;159():113-60.
1994: Mathew A Vadas; A Lopez; J Gamble; Yeesim Khew-Goodall; W Smith; C Bernard; G Cockerill; Peter N Cockerill; F Shannon; Q Sun
Cytokines and allergy.
The Journal of allergy and clinical immunology 1994;94(6 Pt 2):1289-93.
1994: L S Coles; F Occhiodoro; Mathew A Vadas; M Frances Shannon
A sequence-specific single-strand DNA binding protein that contacts repressor sequences in the human GM-CSF promoter.
Nucleic acids research 1994;22(20):4276-83.
1994: G R Ryan; Mathew A Vadas; M Frances Shannon
T-cell functional regions of the human IL-3 proximal promoter.
Molecular reproduction and development 1994;39(2):200-7.
1994: G W Cockerill; G Meyer; L Noack; Mathew A Vadas; Jennifer R Gamble
Characterization of a spontaneously transformed human endothelial cell line.
Laboratory investigation; a journal of technical methods and pathology 1994;71(4):497-509.
1994: D Cooper; C M Butcher; M C Berndt; Mathew A Vadas
P-selectin interacts with a beta 2-integrin to enhance phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):3199-209.
1994: P Moretti; P Simmons; P Thomas; D Haylock; P Rathjen; Mathew A Vadas; Richard J D'Andrea
Identification of homeobox genes expressed in human haemopoietic progenitor cells.
Gene 1994;144(2):213-9.
1994: Tim Hercus; Christopher J Bagley; B Cambareri; M Dottore; Joanna M Woodcock; Mathew A Vadas; M Frances Shannon; Angel F Lopez
Specific human granulocyte-macrophage colony-stimulating factor antagonists.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):5838-42.
1994: Tim Hercus; B Cambareri; M Dottore; J Woodcock; Christopher J Bagley; Mathew A Vadas; M Frances Shannon; Angel F Lopez
Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor.
Blood 1994;83(12):3500-8.
1994: Richard J D'Andrea; J Rayner; P Moretti; A Lopez; G J Goodall; Thomas J Gonda; Mathew A Vadas
A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity.
Blood 1994;83(10):2802-8.
1994: S M Dunn; L S Coles; R K Lang; S Gerondakis; Mathew A Vadas; M Frances Shannon
Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter.
Blood 1994;83(9):2469-79.
1994: S C Barry; Christopher J Bagley; J Phillips; M Dottore; B Cambareri; P Moretti; Richard J D'Andrea; G J Goodall; M Frances Shannon; Mathew A Vadas
Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function.
The Journal of biological chemistry 1994;269(11):8488-92.
1994: W B Smith; Jennifer R Gamble; Mathew A Vadas
The role of granulocyte-macrophage and granulocyte colony-stimulating factors in neutrophil transendothelial migration: comparison with interleukin-8.
Experimental hematology 1994;22(3):329-34.
1994: J A Barbara; W B Smith; Jennifer R Gamble; X Van Ostade; P Vandenabeele; Jan Tavernier; Walter Fiers; Mathew A Vadas; Angel F Lopez
Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.
The EMBO journal 1994;13(4):843-50.
1993: E I Korpelainen; Jennifer R Gamble; W B Smith; G J Goodall; S Qiyu; Joanna M Woodcock; M Dottore; Mathew A Vadas; Angel F Lopez
The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11137-41.
1993: E Kremer; Elizabeth Baker; Richard J D'Andrea; R Slim; H Phillips; P A Moretti; Angel F Lopez; C Petit; Mathew A Vadas; G R Sutherland
A cytokine receptor gene cluster in the X-Y pseudoautosomal region?
Blood 1993;82(1):22-8.
1993: Jennifer R Gamble; Yeesim Khew-Goodall; Mathew A Vadas
Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4494-503.
1993: J R Gamble; L J Matthias; G Meyer; P Kaur; G Russ; R Faull; M C Berndt; Mathew A Vadas
Regulation of in vitro capillary tube formation by anti-integrin antibodies.
The Journal of cell biology 1993;121(4):931-43.
1993: Peter N Cockerill; M Frances Shannon; Andrew G Bert; G R Ryan; Mathew A Vadas
The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2466-70.
1993: W B Smith; Jennifer R Gamble; I Clark-Lewis; Mathew A Vadas
Chemotactic desensitization of neutrophils demonstrates interleukin-8 (IL-8)-dependent and IL-8-independent mechanisms of transmigration through cytokine-activated endothelium.
Immunology 1993;78(3):491-7.
1993: G J Goodall; Christopher J Bagley; Mathew A Vadas; Angel F Lopez
A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands.
Growth factors (Chur, Switzerland) 1993;8(2):87-97.
1993: Yeesim Khew-Goodall; Jennifer R Gamble; Mathew A Vadas
Regulation of adhesion and adhesion molecules in endothelium by transforming growth factor-beta.
Current topics in microbiology and immunology 1993;184():187-99.
1992: Angel F Lopez; M Frances Shannon; S Barry; J A Phillips; B Cambareri; M Dottore; P Simmons; Mathew A Vadas
A human interleukin 3 analog with increased biological and binding activities.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):11842-6.
1992: Angel F Lopez; M J Elliott; J Woodcock; Mathew A Vadas
GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells.
Immunology today 1992;13(12):495-500.
1992: P G Bardy; Angel F Lopez; S Moore; L S Park; Mathew A Vadas; M Frances Shannon
Human GM-CSF receptor alpha-chain gene is highly polymorphic but not rearranged in AML.
Leukemia 1992;6(9):893-7.
1992: L C Dunlop; M P Skinner; Linda Bendall; Emmanuel Favaloro; P A Castaldi; Jeffrey J Gorman; Jennifer R Gamble; Mathew A Vadas; M C Berndt
Characterization of GMP-140 (P-selectin) as a circulating plasma protein.
The Journal of experimental medicine 1992;175(4):1147-50.
1992: Angel F Lopez; M Frances Shannon; Tim Hercus; N A Nicola; B Cambareri; M Dottore; M J Layton; L Eglinton; Mathew A Vadas
Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding.
The EMBO journal 1992;11(3):909-16.
1992: M J Elliott; J Moss; M Dottore; L S Park; Mathew A Vadas; Angel F Lopez
Differential binding of IL-3 and GM-CSF to human monocytes.
Growth factors (Chur, Switzerland) 1992;6(1):15-29.
1992: Angel F Lopez; M Frances Shannon; M M Chia; L Park; Mathew A Vadas
Regulation of human eosinophil production and function by interleukin-5.
Immunology series 1992;57():549-71.
1992: M Frances Shannon; L S Coles; R K Fielke; G J Goodall; C A Lagnado; Mathew A Vadas
Three essential promoter elements mediate tumour necrosis factor and interleukin-1 activation of the granulocyte-colony stimulating factor gene.
Growth factors (Chur, Switzerland) 1992;7(3):181-93.
1991: Angel F Lopez; Mathew A Vadas; Joanna M Woodcock; S E Milton; A Lewis; M J Elliott; D Gillis; R Ireland; E Olwell; L S Park
Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils.
The Journal of biological chemistry 1991;266(36):24741-7.
1991: M J Elliott; Jennifer R Gamble; L S Park; Mathew A Vadas; Angel F Lopez
Inhibition of human monocyte adhesion by interleukin-4.
Blood 1991;77(12):2739-45.
1991: E S Kuczek; M Frances Shannon; L M Pell; Mathew A Vadas
A granulocyte-colony-stimulating factor gene promoter element responsive to inflammatory mediators is functionally distinct from an identical sequence in the granulocyte-macrophage colony-stimulating factor gene.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2426-33.
1991: G R Ryan; S E Milton; Angel F Lopez; P G Bardy; Mathew A Vadas; M Frances Shannon
Human interleukin-3 mRNA accumulation is controlled at both the transcriptional and posttranscriptional level.
Blood 1991;77(6):1195-202.
1991: M O DeNichilo; alastair stewart; Mathew A Vadas; Angel F Lopez
Granulocyte-macrophage colony-stimulating factor is a stimulant of platelet-activating factor and superoxide anion generation by human neutrophils.
The Journal of biological chemistry 1991;266(8):4896-902.
1991: C S Wong; Jennifer R Gamble; M P Skinner; C M Lucas; M C Berndt; Mathew A Vadas
Adhesion protein GMP140 inhibits superoxide anion release by human neutrophils.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2397-401.
1991: Jennifer R Gamble; Mathew A Vadas
Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta 1.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(4):1149-54.
1991: Mathew A Vadas; Angel F Lopez; Jennifer R Gamble; M J Elliot
Role of colony-stimulating factors in leucocyte responses to inflammation and infection.
Current opinion in immunology 1991;3(1):97-104.
1991: W B Smith; Jennifer R Gamble; I Clark-Lewis; Mathew A Vadas
Interleukin-8 induces neutrophil transendothelial migration.
Immunology 1991;72(1):65-72.
1990: Angel F Lopez; J M Eglinton; A B Lyons; P M Tapley; L Bik To; L S Park; S C Clark; Mathew A Vadas
Human interleukin-3 inhibits the binding of granulocyte-macrophage colony-stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity.
Journal of cellular physiology 1990;145(1):69-77.
1990: Jennifer R Gamble; T H Rand; Angel F Lopez; I Clark-Lewis; Mathew A Vadas
Heterogeneity of recombinant granulocyte-macrophage colony-stimulating factor-mediated enhancement of neutrophil adherence to endothelium.
Experimental hematology 1990;18(8):897-902.
1990: Jennifer R Gamble; M P Skinner; M C Berndt; Mathew A Vadas
Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140.
Science (New York, N.Y.) 1990;249(4967):414-7.
1990: M J Elliott; Mathew A Vadas; L G Cleland; Jennifer R Gamble; Angel F Lopez
IL-3 and granulocyte-macrophage colony-stimulating factor stimulate two distinct phases of adhesion in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):167-76.
1990: M Frances Shannon; L M Pell; M J Lenardo; E S Kuczek; F S Occhiodoro; S M Dunn; Mathew A Vadas
A novel tumor necrosis factor-responsive transcription factor which recognizes a regulatory element in hemopoietic growth factor genes.
Molecular and cellular biology 1990;10(6):2950-9.
1990: Y H Atkinson; A W Murray; S Krilis; Mathew A Vadas; Angel F Lopez
Human tumour necrosis factor-alpha (TNF-alpha) directly stimulates arachidonic acid release in human neutrophils.
Immunology 1990;70(1):82-7.
1990: Angel F Lopez; A B Lyons; J M Eglinton; L S Park; L Bik To; S C Clark; Mathew A Vadas
Specific binding of human interleukin-3 and granulocyte-macrophage colony-stimulating factor to human basophils.
The Journal of allergy and clinical immunology 1990;85(1 Pt 1):99-102.
1990: G W Krissansen; C M Lucas; Frank C Stomski; M J Elliott; M C Berndt; A W Boyd; M A Horton; D A Cheresh; Mathew A Vadas; Gordon F Burns
Blood leukocytes bind platelet glycoprotein (IIb-IIIa)' but do not express the vitronectin receptor.
International immunology 1990;2(3):267-77.
1989: J A Phillips; Angel F Lopez; S E Milton; Mathew A Vadas; M Frances Shannon
Synthesis and expression of the gene encoding human interleukin-3.
Gene 1989;84(2):501-7.
1989: M J Elliott; Mathew A Vadas; J M Eglinton; L S Park; L Bik To; Leslie G Cleland; S C Clark; Angel F Lopez
Recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor show common biological effects and binding characteristics on human monocytes.
Blood 1989;74(7):2349-59.
1989: Jennifer R Gamble; M J Elliott; E Jaipargas; Angel F Lopez; Mathew A Vadas
Regulation of human monocyte adherence by granulocyte-macrophage colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7169-73.
1989: Angel F Lopez; J M Eglinton; D Gillis; L S Park; S Clark; Mathew A Vadas
Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7022-6.
1989: B Jin; J L Scott; Mathew A Vadas; Gordon F Burns
TGF beta down-regulates TLiSA1 expression and inhibits the differentiation of precursor lymphocytes into CTL and LAK cells.
Immunology 1989;66(4):570-6.
1989: B Q Jin; A F Lopez; S Gillis; CA Juttner; Mathew A Vadas; Gordon F Burns
Human interleukin 4 regulates the phenotype of lymphocytes generated during mixed lymphocyte culture and inhibits the IL-2-induced development of LAK function in normal and leukaemic cells.
Leukemia research 1989;13(4):297-305.
1988: Angel F Lopez; P G Dyson; L Bik To; M J Elliott; S E Milton; J A Russell; CA Juttner; Y C Yang; S C Clark; Mathew A Vadas
Recombinant human interleukin-3 stimulation of hematopoiesis in humans: loss of responsiveness with differentiation in the neutrophilic myeloid series.
Blood 1988;72(5):1797-804.
1988: Jennifer R Gamble; Mathew A Vadas
Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-beta.
Science (New York, N.Y.) 1988;242(4875):97-9.
1988: Gordon F Burns; C M Lucas; G W Krissansen; J A Werkmeister; D B Scanlon; R J Simpson; Mathew A Vadas
Synergism between membrane gangliosides and Arg-Gly-Asp-directed glycoprotein receptors in attachment to matrix proteins by melanoma cells.
The Journal of cell biology 1988;107(3):1225-30.
1988: Y H Atkinson; Angel F Lopez; Wayne A Marasco; C M Lucas; G G Wong; Gordon F Burns; Mathew A Vadas
Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates f Met-Leu-Phe receptors on human neutrophils.
Immunology 1988;64(3):519-25.
1988: Y H Atkinson; Wayne A Marasco; Angel F Lopez; Mathew A Vadas
Recombinant human tumor necrosis factor-alpha. Regulation of N-formylmethionylleucylphenylalanine receptor affinity and function on human neutrophils.
The Journal of clinical investigation 1988;81(3):759-65.
1988: M Frances Shannon; Jennifer R Gamble; Mathew A Vadas
Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):674-8.
1988: T H Rand; Angel F Lopez; Jennifer R Gamble; Mathew A Vadas
Nedocromil sodium and cromolyn (sodium cromoglycate) selectively inhibit antibody-dependent granulocyte-mediated cytotoxicity.
International archives of allergy and applied immunology 1988;87(2):151-8.
1988: Angel F Lopez; C J Sanderson; Jennifer R Gamble; Hugh D Campbell; Ian G Young; Mathew A Vadas
Recombinant human interleukin 5 is a selective activator of human eosinophil function.
The Journal of experimental medicine 1988;167(1):219-24.
1987: Mathew A Vadas; Angel F Lopez; M F Shannon; Y Atkinson
Human myeloid growth factors.
Immunology and cell biology 1987;65 ( Pt 2)():141-5.