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Ganesan Vaidyanathan

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Marek Pruszynski; Hilde Revets; Ganesan Vaidyanathan; Nick Devoogdt; Eftychia Koumarianou; Tony Lahoutte; Michael R Zalutsky
Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody.
Ganesan Vaidyanathan; P C Welsh; B J White; Donna J Affleck; J Choi; D McDougald; Xiao-Guang Zhao; Michael R Zalutsky
SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies.
Bennett B Chin; Diana Dai; Kim L Greer; Anita Hjelemand; Christopher Lascola; Darryl McDougald; Roger McLendon; Scott D Metzler; Robert Reiman; Jeremy Rich; Haijing Song; Robert W Storms; Ganesan Vaidyanathan
Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.

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2013: Marek Pruszynski; Hilde Revets; Ganesan Vaidyanathan; Nick Devoogdt; Eftychia Koumarianou; Tony Lahoutte; Michael R Zalutsky
Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody.
Nuclear medicine and biology 2013;40(1):52-9.
2012: Ganesan Vaidyanathan; P C Welsh; B J White; Donna J Affleck; J Choi; D McDougald; Xiao-Guang Zhao; Michael R Zalutsky
SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies.
Bioorganic & medicinal chemistry 2012;20(24):6929-39.
2012: Bennett B Chin; Diana Dai; Kim L Greer; Anita Hjelemand; Christopher Lascola; Darryl McDougald; Roger McLendon; Scott D Metzler; Robert Reiman; Jeremy Rich; Haijing Song; Robert W Storms; Ganesan Vaidyanathan
Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.
Current radiopharmaceuticals 2012;5(1):47-58.
2011: Ganesan Vaidyanathan; Michael R Zalutsky; Linda Grasfeder; Darryl McDougald; Bennett Chin
An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2011;69(10):1401-6.
2011: Ganesan Vaidyanathan; Benjamin White; Donna J Affleck; Darryl McDougald; Michael R Zalutsky
Radioiodinated O(6)-Benzylguanine derivatives containing an azido function.
Nuclear medicine and biology 2011;38(1):77-92.
2010: Yukinari Kato; Ganesan Vaidyanathan; Mika Kato Kaneko; Kazuhiko Mishima; Nidhi Srivastava; Vidyalakshmi Chandramohan; Charles N Pegram; Stephen T Keir; Chien-Tsun Kuan; Darell D Bigner; Michael R Zalutsky
Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas.
Nuclear medicine and biology 2010;37(7):785-94.
2010: Marc Hens; Ganesan Vaidyanathan; Xiao-Guang Zhao; Darell D Bigner; Michael R Zalutsky
Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.
Nuclear medicine and biology 2010;37(7):741-50.
2009: Ganesan Vaidyanathan; Haijing Song; Donna J Affleck; Darryl L McDougald; Robert W Storms; Michael R Zalutsky; Bennett B Chin
Targeting aldehyde dehydrogenase: a potential approach for cell labeling.
Nuclear medicine and biology 2009;36(8):919-29.
2009: Ganesan Vaidyanathan; Emmanuelle Jestin; Tove Olafsen; Anna M Wu; Michael R Zalutsky
Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK.
Nuclear medicine and biology 2009;36(6):671-80.
2009: Marc Hens; Ganesan Vaidyanathan; Philip Welsh; Michael R Zalutsky
Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands.
Nuclear medicine and biology 2009;36(2):117-28.
2007: Ganesan Vaidyanathan; Donna J Affleck; Joseph Norman; Susan O'Dorisio; Michael R Zalutsky
A radioiodinated MIBG-octreotate conjugate exhibiting enhanced uptake and retention in SSTR2-expressing tumor cells.
Bioconjugate chemistry 2007;18(6):2122-30.
2007: Michael R Zalutsky; David A Reardon; Oscar R Pozzi; Ganesan Vaidyanathan; Darell D Bigner
Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies.
Nuclear medicine and biology 2007;34(7):779-85.
2007: Ganesan Vaidyanathan; Donna J Affleck; Kevin L Alston; Xiao-Guang Zhao; Marc Hens; Duncan H Hunter; John Babich; Michael R Zalutsky
A kit method for the high level synthesis of [211At]MABG.
Bioorganic & medicinal chemistry 2007;15(10):3430-6.
2007: Ganesan Vaidyanathan; Michael R Zalutsky
Synthesis of N-succinimidyl 4-guanidinomethyl-3-[*I]iodobenzoate: a radio-iodination agent for labeling internalizing proteins and peptides.
Nature protocols 2007;2(2):282-6.
2006: Ganesan Vaidyanathan; Kevin L Alston; Darell D Bigner; Michael R Zalutsky
Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies.
Bioconjugate chemistry 2006;17(4):1085-92.
2006: Sriram Shankar; Michael R Zalutsky; Henry Friedman; Ganesan Vaidyanathan
Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.
Nuclear medicine and biology 2006;33(3):399-407.
2006: Ganesan Vaidyanathan; Michael R Zalutsky
Synthesis of N-succinimidyl 4-[18F]fluorobenzoate, an agent for labeling proteins and peptides with 18F.
Nature protocols 2006;1(4):1655-61.
2006: Ganesan Vaidyanathan; Michael R Zalutsky
Preparation of N-succinimidyl 3-[*I]iodobenzoate: an agent for the indirect radioiodination of proteins.
Nature protocols 2006;1(2):707-13.
2006: Sriram Shankar; Ganesan Vaidyanathan; Chien-Tsun Kuan; Darell D Bigner; Michael R Zalutsky
Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance.
Nuclear medicine and biology 2006;33(1):101-10.
2006: Ganesan Vaidyanathan; Donna J Affleck; Margret Schottelius; Hans-Jürgen Wester; Henry S Friedman; Michael R Zalutsky
Synthesis and evaluation of glycosylated octreotate analogues labeled with radioiodine and 211At via a tin precursor.
Bioconjugate chemistry 2006;17(1):195-203.
2005: Sriram Shankar; Michael R Zalutsky; Ganesan Vaidyanathan
O6-3-[125I]iodobenzyl-2'-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT).
Bioorganic & medicinal chemistry 2005;13(12):3889-98.
2005: Ganesan Vaidyanathan; Donna J Affleck; Michael R Zalutsky
No-carrier-added synthesis of a 4-methyl-substituted meta-iodobenzylguanidine analogue.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2005;62(3):435-40.
2004: Ganesan Vaidyanathan; Abraham Boskovitz; Sriram Shankar; Michael R Zalutsky
Radioiodine and 211At-labeled guanidinomethyl halobenzoyl octreotate conjugates: potential peptide radiotherapeutics for somatostatin receptor-positive cancers.
Peptides 2004;25(12):2087-97.
2004: Sriram Shankar; Ganesan Vaidyanathan; Donna J Affleck; Katia Peixoto; Darell D Bigner; Michael R Zalutsky
Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent.
Nuclear medicine and biology 2004;31(7):909-19.
2004: Ganesan Vaidyanathan; Philip Welsh; Katia C Vitorello; Stacey Snyder; Henry S Friedman; Michael R Zalutsky
A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells.
European journal of nuclear medicine and molecular imaging 2004;31(10):1362-70.
2004: Ganesan Vaidyanathan; Donna J Affleck; Kevin L Alston; Philip Welsh; Michael R Zalutsky
Catabolism of 4-fluoro-3-iodobenzylguanidine and meta-iodobenzylguanidine by SK-N-SH neuroblastoma cells.
Nuclear medicine communications 2004;25(9):947-55.
2004: Marie Boyd; Robert J Mairs; Nicol Keith; Susan C Ross; Philip Welsh; Gamal Akabani; Jonathan Owens; Ganesan Vaidyanathan; Ross Carruthers; Jennifer Dorrens; Michael R Zalutsky
An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects.
The journal of gene medicine 2004;6(8):937-47.
2004: Ganesan Vaidyanathan; Sriram Shankar; Donna J Affleck; Kevin L Alston; Joseph Norman; Philip Welsh; Holly LeGrand; Michael R Zalutsky
Meta-iodobenzylguanidine derivatives containing a second guanidine moiety.
Bioorganic & medicinal chemistry 2004;12(7):1649-56.
2004: Ganesan Vaidyanathan; Donna J Affleck; Joseph Norman; Philip Welsh; Wenge Liu; Stewart P Johnson; Henry S Friedman; Michael R Zalutsky
O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase.
Bioconjugate chemistry 2004;15(2):402-8.
2004: Ganesan Vaidyanathan; Michael R Zalutsky
Imaging drug resistance with radiolabeled molecules.
Current pharmaceutical design 2004;10(24):2965-79.
2003: Ganesan Vaidyanathan; Donna J Affleck; Darell D Bigner; Michael R Zalutsky
N-succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: an acylation agent for labeling internalizing antibodies with alpha-particle emitting 211At.
Nuclear medicine and biology 2003;30(4):351-9.
2003: Ganesan Vaidyanathan; Henry S Friedman; Donna J Affleck; Margret Schottelius; Hans-Jürgen Wester; Michael R Zalutsky
Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1868-76.
2003: Sriram Shankar; Ganesan Vaidyanathan; Donna J Affleck; Philip Welsh; Michael R Zalutsky
N-succinimidyl 3-[(131)I]iodo-4-phosphonomethylbenzoate ([(131)I]SIPMB), a negatively charged substituent-bearing acylation agent for the radioiodination of peptides and mAbs.
Bioconjugate chemistry 2003;14(2):331-41.
2002: Ganesan Vaidyanathan; Donna J Affleck; Darell D Bigner; Michael R Zalutsky
Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate.
Nuclear medicine and biology 2002;29(1):1-11.
2001: Ganesan Vaidyanathan; Sriram Shankar; Donna J Affleck; Philip Welsh; SK Slade; Michael R Zalutsky
Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues.
Bioconjugate chemistry 2001;12(5):798-806.
2001: Ganesan Vaidyanathan; Sriram Shankar; Michael R Zalutsky
Synthesis of ring- and side-chain-substituted m-iodobenzylguanidine analogues.
Bioconjugate chemistry 2001;12(5):786-97.
2001: Ganesan Vaidyanathan; Donna J Affleck; J Li; Philip Welsh; Michael R Zalutsky
A polar substituent-containing acylation agent for the radioiodination of internalizing monoclonal antibodies: N-succinimidyl 4-guanidinomethyl-3-[131I]iodobenzoate ([131I]SGMIB).
Bioconjugate chemistry 2001;12(3):428-38.
2000: Ganesan Vaidyanathan; Donna J Affleck; C M Cavazos; Stewart P Johnson; Sriram Shankar; Henry S Friedman; M O Colvin; Michael R Zalutsky
Radiolabeled guanine derivatives for the in vivo mapping of O(6)-alkylguanine-DNA alkyltransferase: 6-(4-[(18)F]Fluoro-benzyloxy)-9H-purin-2-ylamine and 6-(3-[(131)I]Iodo-benzyloxy)-9H-purin-2-ylamine.
Bioconjugate chemistry 2000;11(6):868-75.
2000: Michael R Zalutsky; Ganesan Vaidyanathan
Astatine-211-labeled radiotherapeutics: an emerging approach to targeted alpha-particle radiotherapy.
Current pharmaceutical design 2000;6(14):1433-55.
2000: Ganesan Vaidyanathan; Donna J Affleck; Philip Welsh; A Srinivasan; M Schmidt; Michael R Zalutsky
Radioiodination and astatination of octreotide by conjugation labeling.
Nuclear medicine and biology 2000;27(4):329-37.
1998: Ganesan Vaidyanathan; Michael R Zalutsky; Timothy R DeGrado
Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine.
Bioconjugate chemistry 1998;9(6):758-64.
1998: Ganesan Vaidyanathan; Michael R Zalutsky
Preparation of 5-[131I]iodo- and 5-[211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction.
Nuclear medicine and biology 1998;25(5):487-96.
1998: SH Cunningham; Robert J Mairs; TE Wheldon; Philip Welsh; Ganesan Vaidyanathan; Michael R Zalutsky
Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissions.
British journal of cancer 1998;77(12):2061-8.
1998: Timothy R DeGrado; Michael R Zalutsky; R Edward Coleman; Ganesan Vaidyanathan
Effects of specific activity on meta-[(131)I]iodobenzylguanidine kinetics in isolated rat heart.
Nuclear medicine and biology 1998;25(1):59-64.
1997: Ganesan Vaidyanathan; Donna J Affleck; Michael R Zalutsky
Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate.
Bioconjugate chemistry 1997;8(5):724-9.
1997: Roy H Larsen; Ganesan Vaidyanathan; Michael R Zalutsky
Cytotoxicity of alpha-particle-emitting 5-[211At]astato-2'-deoxyuridine in human cancer cells.
International journal of radiation biology 1997;72(1):79-90.
1997: Ganesan Vaidyanathan; Michael R Zalutsky
Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue.
Nuclear medicine and biology 1997;24(2):171-8.
1997: Ganesan Vaidyanathan; Xiao-Guang Zhao; Dudley K Strickland; Michael R Zalutsky
No-carrier-added iodine-131-FIBG: evaluation of an MIBG analog.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(2):330-4.
1997: Ganesan Vaidyanathan; Xiao-Guang Zhao; Roy H Larsen; Michael R Zalutsky
3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells.
British journal of cancer 1997;76(2):226-33.
1996: Ganesan Vaidyanathan; Michael R Zalutsky
Targeted therapy using alpha emitters.
Physics in medicine and biology 1996;41(10):1915-31.
1996: Ganesan Vaidyanathan; Henry S Friedman; Stephen T Keir; Michael R Zalutsky
Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model.
Nuclear medicine and biology 1996;23(6):851-6.
1996: Ganesan Vaidyanathan; Henry S Friedman; Stephen T Keir; Michael R Zalutsky
Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
British journal of cancer 1996;73(10):1171-7.
1996: Ganesan Vaidyanathan; Roy H Larsen; Michael R Zalutsky
5-[211 At]astato-2'-deoxyuridine, an alpha particle-emitting endoradiotherapeutic agent undergoing DNA incorporation.
Cancer research 1996;56(6):1204-9.
1996: Ganesan Vaidyanathan; Donna J Affleck; Michael R Zalutsky
No-carrier-added (4-fluoro-3-[131I]iodobenzyl)guanidine and (3-[211At]astato-4-fluorobenzyl)guanidine.
Bioconjugate chemistry 1996;7(1):102-7.
1995: Craig J Reist; Gary E Archer; S N Kurpad; Carol J Wikstrand; Ganesan Vaidyanathan; M C Willingham; Moscatello David; Albert J Wong; Darell D Bigner; Michael R Zalutsky
Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts.
Cancer research 1995;55(19):4375-82.
1995: Ganesan Vaidyanathan; Michael R Zalutsky
Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection.
Nuclear medicine and biology 1995;22(6):759-64.
1995: Ganesan Vaidyanathan; Donna J Affleck; Michael R Zalutsky
Validation of 4-[fluorine-18]fluoro-3-iodobenzylguanidine as a positron-emitting analog of MIBG.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(4):644-50.
1995: Dudley K Strickland; Ganesan Vaidyanathan; Henry S Friedman; Michael R Zalutsky
Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines.
Journal of neuro-oncology 1995;25(1):9-17.
1995: Ganesan Vaidyanathan; Michael R Zalutsky
No-carrier-added meta-[123I]iodobenzylguanidine: synthesis and preliminary evaluation.
Nuclear medicine and biology 1995;22(1):61-4.
1995: E L Johnson; Timothy G Turkington; Ronald J Jaszczak; David Gilland; Ganesan Vaidyanathan; Kim L Greer; R Edward Coleman; Michael R Zalutsky
Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models.
Nuclear medicine and biology 1995;22(1):45-54.
1995: Timothy R DeGrado; Michael R Zalutsky; Ganesan Vaidyanathan
Uptake mechanisms of meta-[123I]iodobenzylguanidine in isolated rat heart.
Nuclear medicine and biology 1995;22(1):1-12.
1994: Dudley K Strickland; Ganesan Vaidyanathan; Michael R Zalutsky
Cytotoxicity of alpha-particle-emitting m-[211At]astatobenzylguanidine on human neuroblastoma cells.
Cancer research 1994;54(20):5414-9.
1994: Ganesan Vaidyanathan; Donna J Affleck; Michael R Zalutsky
(4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography.
Journal of medicinal chemistry 1994;37(21):3655-62.
1994: Rodney L Page; Pradeep K Garg; Ganesan Vaidyanathan; M R Zalutsky
Preclinical evaluation and PET imaging of 18F-labeled Mel-14 F(ab')2 fragment in normal dogs.
Nuclear medicine and biology 1994;21(7):911-9.
1994: Ganesan Vaidyanathan; Michael R Zalutsky
Improved synthesis of N-succinimidyl 4-[18F]fluorobenzoate and its application to the labeling of a monoclonal antibody fragment.
Bioconjugate chemistry 1994;5(4):352-6.
1994: Ganesan Vaidyanathan; Dudley K Strickland; Michael R Zalutsky
Meta-[211At]astatobenzylguanidine: further evaluation of a potential therapeutic agent.
International journal of cancer. Journal international du cancer 1994;57(6):908-13.
1994: Ganesan Vaidyanathan; Donna J Affleck; Michael R Zalutsky
Monoclonal antibody F(ab')2 fragment labeled with N-succinimidyl 2,4-dimethoxy-3-halobenzoates: in vivo comparison of iodinated and astatinated fragments.
Nuclear medicine and biology 1994;21(1):105-10.
1993: Timothy G Turkington; Michael R Zalutsky; Ronald J Jaszczak; Pradeep K Garg; Ganesan Vaidyanathan; R Edward Coleman
Measuring astatine-211 distributions with SPECT.
Physics in medicine and biology 1993;38(8):1121-30.
1993: Ganesan Vaidyanathan; Michael R Zalutsky
No-carrier-added synthesis of meta-[131I]iodobenzylguanidine.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1993;44(3):621-8.
1993: Ganesan Vaidyanathan; Donna J Affleck; Michael R Zalutsky
Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate.
Bioconjugate chemistry 1993;4(1):78-84.
1992: Ganesan Vaidyanathan; Michael R Zalutsky
1-(m-[211At]astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation.
Bioconjugate chemistry 1992;3(6):499-503.
1992: Ganesan Vaidyanathan; Darell D Bigner; Michael R Zalutsky
Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(8):1535-41.
1992: Ganesan Vaidyanathan; Michael R Zalutsky
Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(3):275-81.
1990: Ganesan Vaidyanathan; Michael R Zalutsky
Radioiodination of antibodies via N-succinimidyl 2,4-dimethoxy-3-(trialkylstannyl)benzoates.
Bioconjugate chemistry 1990;1(6):387-93.
1990: Ganesan Vaidyanathan; Michael R Zalutsky
Protein radiohalogenation: observations on the design of N-succinimidyl ester acylation agents.
Bioconjugate chemistry 1990;1(4):269-73.