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William Vainchenker

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Living Beings

Mice

Physiology

Chemicals & Drugs

Disorders

Myeloproliferative Disorders

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Publications

TOP 3
Gilles Laure; Bluteau Dominique; Boukour Siham; Chang Yunhua; Zhang Yanyan; Robert Thomas; Dessen Philippe; Debili Najet; Bernard Olivier A; Vainchenker William; Raslova Hana
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.
Bernard Olivier A; Delhommeau François; Fontenay Michaela; Vainchenker William
[Mutations in TET2 in myeloid cancers]
Kosmider Olivier; Gelsi-Boyer Véronique; Cheok Meyling; Grabar Sophie; Della-Valle Véronique; Picard Françoise; Viguié Franck; Quesnel Bruno; Beyne-Rauzy Odile; Solary Eric; Vey Norbert; Hunault-Berger Mathilde; Fenaux Pierre; Mansat-De Mas Véronique; Delabesse Eric; Guardiola Philippe; Lacombe Catherine; Vainchenker William; Preudhomme Claude; Dreyfus François; Bernard Olivier A; Birnbaum Daniel; Fontenay Michaëla;
TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

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All Publications

2009: Gilles Laure; Bluteau Dominique; Boukour Siham; Chang Yunhua; Zhang Yanyan; Robert Thomas; Dessen Philippe; Debili Najet; Bernard Olivier A; Vainchenker William; Raslova Hana
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.
Blood 2009;114(19):4221-32.
2009: Bernard Olivier A; Delhommeau François; Fontenay Michaela; Vainchenker William
[Mutations in TET2 in myeloid cancers]
Médecine sciences : M/S 2009;25(10):785-8.
2009: Kosmider Olivier; Gelsi-Boyer Véronique; Cheok Meyling; Grabar Sophie; Della-Valle Véronique; Picard Françoise; Viguié Franck; Quesnel Bruno; Beyne-Rauzy Odile; Solary Eric; Vey Norbert; Hunault-Berger Mathilde; Fenaux Pierre; Mansat-De Mas Véronique; Delabesse Eric; Guardiola Philippe; Lacombe Catherine; Vainchenker William; Preudhomme Claude; Dreyfus François; Bernard Olivier A; Birnbaum Daniel; Fontenay Michaëla;
TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).
Blood 2009;114(15):3285-91.
2009: Tefferi Ayalew; Lim Ken-Hong; Levine Ross
Mutation in TET2 in myeloid cancers.
The New England journal of medicine 2009;361(11):1117; author reply 1117-8.
2009: Plo Isabelle; Zhang Yanyan; Le Couédic Jean-Pierre; Nakatake Mayuka; Boulet Jean-Michel; Itaya Miki; Smith Steven O; Debili Najet; Constantinescu Stefan N; Vainchenker William; Louache Fawzia; de Botton Stéphane
An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.
The Journal of experimental medicine 2009;206(8):1701-7.
2009: Jedidi Abire; Marty Caroline; Oligo Charleen; Jeanson-Leh Laurence; Ribeil Jean-Antoine; Casadevall Nicole; Galy Anne; Vainchenker William; Villeval Jean-Luc
Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines.
Blood 2009;114(9):1842-51.
2009: Saint-Martin Cécile; Leroy Gwendoline; Delhommeau François; Panelatti Gérard; Dupont Sabrina; James Chloé; Plo Isabelle; Bordessoule Dominique; Chomienne Christine; Delannoy André; Devidas Alain; Gardembas-Pain Martine; Isnard Françoise; Plumelle Yves; Bernard Olivier; Vainchenker William; Najman Albert; Bellanné-Chantelot Christine;
Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms.
Blood 2009;114(8):1628-32.
2009: Klimchenko Olena; Mori Marcella; Distefano Antonio; Langlois Thierry; Larbret Frédéric; Lecluse Yann; Feraud Olivier; Vainchenker William; Norol Françoise; Debili Najet
A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.
Blood 2009;114(8):1506-17.
2009: Schaffner-Reckinger E; Salsmann A; Debili N; Bellis J; De Mey J; Vainchenker W; Ouwehand W H; Kieffer N
Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells.
Journal of thrombosis and haemostasis : JTH 2009;7(7):1207-17.
2009: Delhommeau François; Dupont Sabrina; Della Valle Véronique; James Chloé; Trannoy Severine; Massé Aline; Kosmider Olivier; Le Couedic Jean-Pierre; Robert Fabienne; Alberdi Antonio; Lécluse Yann; Plo Isabelle; Dreyfus François J; Marzac Christophe; Casadevall Nicole; Lacombe Catherine; Romana Serge P; Dessen Philippe; Soulier Jean; Viguié Franck; Fontenay Michaela; Vainchenker William; Bernard Olivier A
Mutation in TET2 in myeloid cancers.
The New England journal of medicine 2009;360(22):2289-301.
2009: Marty Caroline; Chaligné Ronan; Lacout Catherine; Constantinescu Stefan N; Vainchenker William; Villeval Jean-Luc
Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity.
The Journal of biological chemistry 2009;284(18):11781-91.
2009: Mercher Thomas; Raffel Glen D; Moore Sandra A; Cornejo Melanie G; Baudry-Bluteau Dominique; Cagnard Nicolas; Jesneck Jonathan L; Pikman Yana; Cullen Dana; Williams Ifor R; Akashi Koichi; Shigematsu Hirokazu; Bourquin Jean-Pierre; Giovannini Marco; Vainchenker William; Levine Ross L; Lee Benjamin H; Bernard Olivier A; Gilliland D Gary
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
The Journal of clinical investigation 2009;119(4):852-64.
2009: Coppo Paul; Dusanter-Fourt Isabelle; Vainchenker William; Turhan Ali G
BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels.
Cellular signalling 2009;21(1):52-60.
2009: Plo Isabelle; Vainchenker William
Molecular and genetic bases of myeloproliferative disorders: questions and perspectives.
Clinical lymphoma & myeloma 2009;9 Suppl 3():S329-39.
2008: Malinge Sébastien; Ragu Christine; Della-Valle Veronique; Pisani Didier; Constantinescu Stefan N; Perez Christelle; Villeval Jean-Luc; Reinhardt Dirk; Landman-Parker Judith; Michaux Lucienne; Dastugue Nicole; Baruchel André; Vainchenker William; Bourquin Jean-Pierre; Penard-Lacronique Virginie; Bernard Olivier A
Activating mutations in human acute megakaryoblastic leukemia.
Blood 2008;112(10):4220-6.
2008: Lordier Larissa; Jalil Abdelali; Aurade Fréderic; Larbret Fréderic; Larghero Jerôme; Debili Najet; Vainchenker William; Chang Yunhua
Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling.
Blood 2008;112(8):3164-74.
2008: James Chloe; Mazurier Frederic; Dupont Sabrina; Chaligne Ronan; Lamrissi-Garcia Isabelle; Tulliez Micheline; Lippert Eric; Mahon François-Xavier; Pasquet Jean-Max; Etienne Gabriel; Delhommeau François; Giraudier Stephane; Vainchenker William; de Verneuil Hubert
The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity.
Blood 2008;112(6):2429-38.
2008: Vainchenker William; Dusa Alexandra; Constantinescu Stefan N
JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.
Seminars in cell & developmental biology 2008;19(4):385-93.
2008: Bouilloux Fabrice; Juban Gaëtan; Cohet Nathalie; Buet Dorothée; Guyot Boris; Vainchenker William; Louache Fawzia; Morlé François
EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation.
Blood 2008;112(3):576-84.
2008: Plo Isabelle; Nakatake Mayuka; Malivert Laurent; de Villartay Jean-Pierre; Giraudier Stéphane; Villeval Jean-Luc; Wiesmuller Lisa; Vainchenker William
JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.
Blood 2008;112(4):1402-12.
2008: Kouroupi Eirini; Zoi Katerina; Parquet Nathalie; Zoi Christine; Kiladjian Jean-Jacques; Grigoraki Vassiliki; Vainchenker William; Lellouche Franck; Marzac Christophe; Schlageter Marie-Hélène; Dosquet Christine; Scott Linda M; Fenaux Pierre; Loukopoulos Dimitris; Chomienne Christine; Cassinat Bruno
Mutations in exon 12 of JAK2 are mainly found in JAK2 V617F-negative polycythaemia vera patients.
British journal of haematology 2008;142(4):676-9.
2008: Debili Najet; Vainchenker William
[From giant to micro: a platelet story]
Médecine sciences : M/S 2008;24(5):467-9.
2008: Gilles Laure; Guièze Romain; Bluteau Dominique; Cordette-Lagarde Véronique; Lacout Catherine; Favier Rémi; Larbret Fréderic; Debili Najet; Vainchenker William; Raslova Hana
P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.
Blood 2008;111(8):4081-91.
2008: Ghevaert Cedric; Salsmann Alexandre; Watkins Nicholas A; Schaffner-Reckinger Elisabeth; Rankin Angela; Garner Stephen F; Stephens Jonathan; Smith Graham A; Debili Najet; Vainchenker William; de Groot Philip G; Huntington James A; Laffan Mike; Kieffer Nelly; Ouwehand Willem H
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.
Blood 2008;111(7):3407-14.
2008: Lahmar Medhi; Catelain Cyril; Poirault Sonia; Dorsch Marion; Villeval Jean-Luc; Vainchenker William; Albagli Olivier; Lauret Evelyne
Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation.
Stem cells (Dayton, Ohio) 2008;26(3):621-9.
2008: Haond C; Drouet M; Derdouch S; Bonnet M-L; Norol F; Mayol J-F; Vainchenker W; LeGrand R; Turhan A G; Herodin F
In vitro and in vivo evaluation of the haematopoietic potential of skeletal muscle in a non-human primate model.
Bone marrow transplantation 2008;41(6):579-84.
2007: Chaligné Ronan; James Chloé; Tonetti Carole; Besancenot Rodolphe; Le Couédic Jean Pierre; Fava Fanny; Mazurier Fréderic; Godin Isabelle; Maloum Karim; Larbret Frédéric; Lécluse Yann; Vainchenker William; Giraudier Stéphane
Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis.
Blood 2007;110(10):3735-43.
2007: Motté Nelly; Saulnier Patrick; Le Couedic Jean-Pierre; Soria Jean-Charles; Delaloge Suzette; Boige Valérie; Pautier Patricia; Vainchenker William; Bidart Jean-Michel; Villeval Jean-Luc
Mutations in JAK2V617F homologous domain of JAK genes are uncommon in solid tumors.
International journal of cancer. Journal international du cancer 2007;121(9):2113-5.
2007: Haond Celine; Farace Françoise; Guillier Martine; Lécluse Yann; Mazurier Frederic; Vainchenker William; Turhan Ali G
Quantitative and qualitative in vitro analysis of the stem cell potential of hematopoietic cells purified from murine skeletal muscle.
Cell research 2007;17(9):783-91.
2007: Dupont Sabrina; Massé Aline; James Chloé; Teyssandier Irène; Lécluse Yann; Larbret Frédéric; Ugo Valérie; Saulnier Patrick; Koscielny Serge; Le Couédic Jean Pierre; Casadevall Nicole; Vainchenker William; Delhommeau François
The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera.
Blood 2007;110(3):1013-21.
2007: Wagner-Ballon Orianne; Pisani Didier F; Gastinne Thomas; Tulliez Micheline; Chaligné Ronan; Lacout Catherine; Auradé Frédéric; Villeval Jean-Luc; Gonin Patrick; Vainchenker William; Giraudier Stéphane
Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.
Blood 2007;110(1):345-53.
2007: Gaikwad Amos; Verstovsek Srdan; Yoon Donghoon; Chang Ko-Tung; Manshouri Taghi; Nussenzveig Roberto; Cortes Jorge; Vainchenker William; Prchal Josef T
Imatinib effect on growth and signal transduction in polycythemia vera.
Experimental hematology 2007;35(6):931-8.
2007: Hookham Michelle B; Elliott Joanne; Suessmuth Yvonne; Staerk Judith; Ward Alister C; Vainchenker William; Percy Melanie J; McMullin Mary Frances; Constantinescu Stefan N; Johnston James A
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3.
Blood 2007;109(11):4924-9.
2007: Zetterberg Eva; Vannucchi Alessandro M; Migliaccio Anna Rita; Vainchenker William; Tulliez Micheline; Dickie Renée; Hasselbalch Hans; Rogers Rick; Palmblad Jan
Pericyte coverage of abnormal blood vessels in myelofibrotic bone marrows.
Haematologica 2007;92(5):597-604.
2007: Buet D; Raslova H; Geay J-F; Jarrier P; Lazar V; Turhan A; Morlé F; Vainchenker W; Louache F
p210(BCR-ABL) reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(5):917-25.
2007: Chang Yunhua; Auradé Frédéric; Larbret Frédéric; Zhang Yanyan; Le Couedic Jean-Pierre; Momeux Laurence; Larghero Jerôme; Bertoglio Jacques; Louache Fawzia; Cramer Elisabeth; Vainchenker William; Debili Najet
Proplatelet formation is regulated by the Rho/ROCK pathway.
Blood 2007;109(10):4229-36.
2007: Raslova Hana; Kauffmann Audrey; Sekkaï Dalila; Ripoche Hugues; Larbret Fréderic; Robert Thomas; Le Roux Diana Tronik; Kroemer Guido; Debili Najet; Dessen Philippe; Lazar Vladimir; Vainchenker William
Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach.
Blood 2007;109(8):3225-34.
2007: Malinge Sebastien; Ben-Abdelali Raouf; Settegrana Catherine; Radford-Weiss Isabelle; Debre Marianne; Beldjord Kheira; Macintyre Elizabeth A; Villeval Jean-Luc; Vainchenker William; Berger Roland; Bernard Olivier A; Delabesse Eric; Penard-Lacronique Virginie
Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia.
Blood 2007;109(5):2202-4.
2007: Staerk J; Kallin A; Royer Y; Diaconu C C; Dusa A; Demoulin J-B; Vainchenker W; Constantinescu S N
JAK2, the JAK2 V617F mutant and cytokine receptors.
Pathologie-biologie 2007;55(2):88-91.
2007: Kiladjian J J; Casadevall N; Vainchenker W; Fenaux P
The first international meeting on V617F JAK2 mutation and its relevance in Philadelphia-negative myeloproliferative disorders.
Pathologie-biologie 2007;55(2):85-7.
2007: Gastinne Thomas; Vigant Frédéric; Lavenu-Bombled Cecile; Wagner-Ballon Orianne; Tulliez Micheline; Chagraoui Hédia; Villeval Jean-Luc; Lacout Catherine; Perricaudet Michel; Vainchenker William; Benihoud Karim; Giraudier Stéphane
Adenoviral-mediated TGF-beta1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development.
Experimental hematology 2007;35(1):64-74.
2007: Zhang Yanyan; Wittner Monika; Bouamar Hakim; Jarrier Peggy; Vainchenker William; Louache Fawzia
Identification of CXCR4 as a new nitric oxide-regulated gene in human CD34+ cells.
Stem cells (Dayton, Ohio) 2007;25(1):211-9.
2007: Delhommeau François; Dupont Sabrina; Tonetti Carole; Massé Aline; Godin Isabelle; Le Couedic Jean-Pierre; Debili Najet; Saulnier Patrick; Casadevall Nicole; Vainchenker William; Giraudier Stéphane
Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.
Blood 2007;109(1):71-7.
2007: Raoul William; Wagner-Ballon Orianne; Saber Guitanouch; Hulin Anne; Marcos Elisabeth; Giraudier Stéphane; Vainchenker William; Adnot Serge; Eddahibi Saadia; Maitre Bernard
Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.
Respiratory research 2007;8():8.
2006: Delhommeau F; Pisani D F; James C; Casadevall N; Constantinescu S; Vainchenker W
Oncogenic mechanisms in myeloproliferative disorders.
Cellular and molecular life sciences : CMLS 2006;63(24):2939-53.
2006: Martínez María Carmen; Larbret Fréderic; Zobairi Fatiha; Coulombe Josée; Debili Najet; Vainchenker William; Ruat Martial; Freyssinet Jean-Marie
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.
Blood 2006;108(9):3012-20.
2006: Nurden Paquita; Debili Najet; Vainchenker William; Bobe Regis; Bredoux Raymonde; Corvazier Elisabeth; Combrie Robert; Fressinaud Edith; Meyer Dominique; Nurden Alan T; Enouf Jocelyne
Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia.
Blood 2006;108(8):2587-95.
2006: Kiladjian Jean-Jacques; Cassinat Bruno; Turlure Pascal; Cambier Nathalie; Roussel Murielle; Bellucci Sylvia; Menot Marie-Laurence; Massonnet Gerald; Dutel Jean-Luc; Ghomari Kamel; Rousselot Philippe; Grange Marie-Jose; Chait Yasmina; Vainchenker William; Parquet Nathalie; Abdelkader-Aljassem Lina; Bernard Jean-François; Rain Jean-Didier; Chevret Sylvie; Chomienne Christine; Fenaux Pierre
High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a.
Blood 2006;108(6):2037-40.
2006: Garçon Loïc; Rivat Christine; James Chloé; Lacout Catherine; Camara-Clayette Valérie; Ugo Valérie; Lecluse Yann; Bennaceur-Griscelli Annelise; Vainchenker William
Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells.
Blood 2006;108(5):1551-4.
2006: Lacout Catherine; Pisani Didier F; Tulliez Micheline; Gachelin Françoise Moreau; Vainchenker William; Villeval Jean-Luc
JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.
Blood 2006;108(5):1652-60.
2006: Camara-Clayette Valérie; Le Pesteur Françoise; Vainchenker William; Sainteny Françoise
Quantitative Oct4 overproduction in mouse embryonic stem cells results in prolonged mesoderm commitment during hematopoietic differentiation in vitro.
Stem cells (Dayton, Ohio) 2006;24(8):1937-45.
2006: Coppo Paul; Flamant Stéphane; De Mas Véronique; Jarrier Peggy; Guillier Martine; Bonnet Marie-Laure; Lacout Catherine; Guilhot François; Vainchenker William; Turhan Ali G
BCR-ABL activates STAT3 via JAK and MEK pathways in human cells.
British journal of haematology 2006;134(2):171-9.
2006: Bellanné-Chantelot Christine; Chaumarel Isabelle; Labopin Myriam; Bellanger Florence; Barbu Véronique; De Toma Claudia; Delhommeau François; Casadevall Nicole; Vainchenker William; Thomas Gilles; Najman Albert
Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders.
Blood 2006;108(1):346-52.
2006: Sabri Siham; Foudi Adlen; Boukour Siham; Franc Brigitte; Charrier Sabine; Jandrot-Perrus Martine; Farndale Richard W; Jalil Abdelali; Blundell Mike P; Cramer Elisabeth M; Louache Fawzia; Debili Najet; Thrasher Adrian J; Vainchenker William
Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment.
Blood 2006;108(1):134-40.
2006: Villeval Jean-Luc; James Chloé; Pisani Didier F; Casadevall Nicole; Vainchenker William
New insights into the pathogenesis of JAK2 V617F-positive myeloproliferative disorders and consequences for the management of patients.
Seminars in thrombosis and hemostasis 2006;32(4 Pt 2):341-51.
2006: Wagner-Ballon Orianne; Chagraoui Hédia; Prina Eric; Tulliez Micheline; Milon Geneviève; Raslova Hana; Villeval Jean-Luc; Vainchenker William; Giraudier Stéphane
Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6425-33.
2006: Castedo Maria; Coquelle Arnaud; Vivet Sonia; Vitale Ilio; Kauffmann Audrey; Dessen Philippe; Pequignot Marie O; Casares Noelia; Valent Alexandre; Mouhamad Shahul; Schmitt Elise; Modjtahedi Nazanine; Vainchenker William; Zitvogel Laurence; Lazar Vladimir; Garrido Carmen; Kroemer Guido
Apoptosis regulation in tetraploid cancer cells.
The EMBO journal 2006;25(11):2584-95.
2006: Capron Claude; Lécluse Yann; Kaushik Anna Lila; Foudi Adlen; Lacout Catherine; Sekkai Dalila; Godin Isabelle; Albagli Olivier; Poullion Isabelle; Svinartchouk Fedor; Schanze Elisabeth; Vainchenker William; Sablitzky Fred; Bennaceur-Griscelli Annelise; Duménil Dominique
The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation.
Blood 2006;107(12):4678-86.
2006: Olivier Aurelie; Jeanson-Leh Laurence; Bouma Gerben; Compagno Daniel; Blondeau Johanna; Seye Khalil; Charrier Sabine; Burns Siobhan; Thrasher Adrian J; Danos Olivier; Vainchenker William; Galy Anne
A partial down-regulation of WASP is sufficient to inhibit podosome formation in dendritic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(4):729-37.
2006: Foudi Adlen; Jarrier Peggy; Zhang Yanyan; Wittner Monika; Geay Jean-Francois; Lecluse Yann; Nagasawa Takashi; Vainchenker William; Louache Fawzia
Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice.
Blood 2006;107(6):2243-51.
2006: Raslova Hana; Baccini Véronique; Loussaief Lamya; Comba Béatrice; Larghero Jérôme; Debili Najet; Vainchenker William
Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.
Blood 2006;107(6):2303-10.
2006: Staerk Judith; Lacout Catherine; Sato Takeshi; Smith Steven O; Vainchenker William; Constantinescu Stefan N
An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.
Blood 2006;107(5):1864-71.
2006: James C; Delhommeau F; Marzac C; Teyssandier I; Couédic J-P Le; Giraudier S; Roy L; Saulnier P; Lacroix L; Maury S; Tulliez M; Vainchenker W; Ugo V; Casadevall N
Detection of JAK2 V617F as a first intention diagnostic test for erythrocytosis.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(2):350-3.
2006: Chagraoui Hedia; Wendling Françoise; Vainchenker William
Pathogenesis of myelofibrosis with myeloid metaplasia: Insight from mouse models.
Best practice & research. Clinical haematology 2006;19(3):399-412.
2005: Kosmider Olivier; Denis Nicole; Lacout Catherine; Vainchenker William; Dubreuil Patrice; Moreau-Gachelin Françoise
Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.
Cancer cell 2005;8(6):467-78.
2005: James Chloé; Ugo Valérie; Casadevall Nicole; Constantinescu Stefan N; Vainchenker William
A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects.
Trends in molecular medicine 2005;11(12):546-54.
2005: Staerk Judith; Kallin Anders; Demoulin Jean-Baptiste; Vainchenker William; Constantinescu Stefan N
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
The Journal of biological chemistry 2005;280(51):41893-9.
2005: Sekkaï Dalila; Gruel Gaëtan; Herry Magali; Moucadel Virginie; Constantinescu Stefan N; Albagli Olivier; Tronik-Le Roux Diana; Vainchenker William; Bennaceur-Griscelli Annelise
Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells.
Stem cells (Dayton, Ohio) 2005;23(10):1634-42.
2005: Berthebaud Magali; Rivière Christel; Jarrier Peggy; Foudi Adlen; Zhang Yanyan; Compagno Daniel; Galy Anne; Vainchenker William; Louache Fawzia
RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes.
Blood 2005;106(9):2962-8.
2005: Zhao Zhizhuang Joe; Vainchenker William; Krantz Sanford B; Casadevall Nicole; Constantinescu Stefan N
Role of tyrosine kinases and phosphatases in polycythemia vera.
Seminars in hematology 2005;42(4):221-9.
2005: Le Scolan Erwan; Pchejetski Dimitri; Banno Yoshiko; Denis Nicole; Mayeux Patrick; Vainchenker William; Levade Thierry; Moreau-Gachelin Françoise
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.
Blood 2005;106(5):1808-16.
2005: Flamant S; Kortulewski T; Dugray A; Bonnet M-L; Guillier M; Guilhot F; Bourhis J-H; Vainchenker W; Tronik-Le Roux D; Turhan A G
Osteopontin is upregulated by BCR-ABL.
Biochemical and biophysical research communications 2005;333(4):1378-84.
2005: Proust Alexis; Guillet Benoît; Pellier Isabelle; Rachieru Petronela; Hoarau Cyrille; Claeyssens Ségolène; Léonard Claude; Charrier Sabine; Vainchenker William; Tchernia Gil; Delaunay Jean
Recurrent V75M mutation within the Wiskott-Aldrich syndrome protein: description of a homozygous female patient.
European journal of haematology 2005;75(1):54-9.
2005: Ugo Valérie; James Chloé; Vainchenker William
[A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera]
Médecine sciences : M/S 2005;21(6-7):669-70.
2005: Bennaceur-Griscelli A; Vainchenker W
[Hope and limits in cell therapies]
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 2005;12(2):73-6.
2005: Komura Emiko; Tonetti Carole; Penard-Lacronique Virginie; Chagraoui Hédia; Lacout Catherine; Lecouédic Jean Pierre; Rameau Philippe; Debili Najet; Vainchenker William; Giraudier Stéphane
Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression.
Cancer research 2005;65(8):3281-9.
2005: Geay Jean-Francois; Buet Dorothée; Zhang Yanyan; Foudi Adlen; Jarrier Peggy; Berthebaud Magali; Turhan Ali G; Vainchenker William; Louache Fawzia
p210BCR-ABL inhibits SDF-1 chemotactic response via alteration of CXCR4 signaling and down-regulation of CXCR4 expression.
Cancer research 2005;65(7):2676-83.
2005: James Chloé; Ugo Valérie; Le Couédic Jean-Pierre; Staerk Judith; Delhommeau François; Lacout Catherine; Garçon Loïc; Raslova Hana; Berger Roland; Bennaceur-Griscelli Annelise; Villeval Jean Luc; Constantinescu Stefan N; Casadevall Nicole; Vainchenker William
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.
Nature 2005;434(7037):1144-8.
2005: Dando Jonathan S; Tavian Manuela; Catelain Cyril; Poirault Sonia; Bennaceur-Griscelli Annelise; Sainteny Françoise; Vainchenker William; Péault Bruno; Lauret Evelyne
Notch/Delta4 interaction in human embryonic liver CD34+ CD38- cells: positive influence on BFU-E production and LTC-IC potential maintenance.
Stem cells (Dayton, Ohio) 2005;23(4):550-60.
2005: Charrier S; Stockholm D; Seye K; Opolon P; Taveau M; Gross D-A; Bucher-Laurent S; Delenda C; Vainchenker W; Danos O; Galy A
A lentiviral vector encoding the human Wiskott-Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice.
Gene therapy 2005;12(7):597-606.
2005: Garçon Loïc; Lacout Catherine; Svinartchouk Fédor; Le Couédic Jean-Pierre; Villeval Jean-Luc; Vainchenker William; Duménil Dominique
Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells.
Blood 2005;105(4):1448-55.
2005: Vainchenker William; Constantinescu Stefan N
A unique activating mutation in JAK2 (V617F) is at the origin of polycythemia vera and allows a new classification of myeloproliferative diseases.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005;():195-200.
2004: Burns Siobhan; Cory Giles O; Vainchenker William; Thrasher Adrian J
Mechanisms of WASp-mediated hematologic and immunologic disease.
Blood 2004;104(12):3454-62.
2004: Raslova Hana; Favier Rémi; Albagli Olivier; Vainchenker William
[Fli1 haploinsufficiency underlies Paris-Trousseau thrombopenia]
Médecine sciences : M/S 2004;20(11):962-4.
2004: Sabri Siham; Jandrot-Perrus Martine; Bertoglio Jacques; Farndale Richard W; Mas Véronique Mansat-De; Debili Najet; Vainchenker William
Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes.
Blood 2004;104(10):3117-25.
2004: Borg Christophe; Jalil Abdelali; Laderach Diego; Maruyama Kouji; Wakasugi Hiro; Charrier Sabine; Ryffel Bernhard; Cambi Alessandra; Figdor Carl; Vainchenker William; Galy Anne; Caignard Anne; Zitvogel Laurence
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
Blood 2004;104(10):3267-75.
2004: Paulus Jean-Michel; Debili Najet; Larbret Frédéric; Levin Jack; Vainchenker William
Thrombopoietin responsiveness reflects the number of doublings undergone by megakaryocyte progenitors.
Blood 2004;104(8):2291-8.
2004: Charrier Sabine; Michaud Annie; Badaoui Sabrina; Giroux Sébastien; Ezan Eric; Sainteny Françoise; Corvol Pierre; Vainchenker William
Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells.
Blood 2004;104(4):978-85.
2004: Raslova Hana; Komura Emiko; Le Couédic Jean Pierre; Larbret Frederic; Debili Najet; Feunteun Jean; Danos Olivier; Albagli Olivier; Vainchenker William; Favier Rémi
FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia.
The Journal of clinical investigation 2004;114(1):77-84.
2004: Decraene C; Garçon L; Lacout C; Sabri S; Auffray C; Vainchenker W; Duménil D; Piétu G; Svinartchuk F
Zyxin is up-regulated during megakaryocytic differentiation of human UT-7/c-mpl cells.
Biochemical and biophysical research communications 2004;318(2):439-43.
2004: Castedo Maria; Perfettini Jean-Luc; Roumier Thomas; Valent Alexander; Raslova Hana; Yakushijin Kenichi; Horne David; Feunteun Jean; Lenoir Gilbert; Medema René; Vainchenker William; Kroemer Guido
Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.
Oncogene 2004;23(25):4362-70.
2004: Lauret E; Catelain C; Titeux M; Poirault S; Dando J S; Dorsch M; Villeval J-L; Groseil A; Vainchenker W; Sainteny F; Bennaceur-Griscelli A
Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(4):788-97.
2004: Millot Gaël A; Vainchenker William; Duménil Dominique; Svinarchuk Fédor
Differential signalling of NH2-terminal flag-labelled thrombopoietin receptor activated by TPO or anti-FLAG antibodies.
Cellular signalling 2004;16(3):355-63.
2004: Ugo Valérie; Marzac Christophe; Teyssandier Irène; Larbret Frédéric; Lécluse Yann; Debili Najet; Vainchenker William; Casadevall Nicole
Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera.
Experimental hematology 2004;32(2):179-87.
2004: Farace Francoise; Prestoz Laetitita; Badaoui Sabrina; Guillier Martine; Haond Celine; Opolon Paule; Thomas Jean-Leon; Zalc Bernard; Vainchenker William; Turhan Ali G
Evaluation of hematopoietic potential generated by transplantation of muscle-derived stem cells in mice.
Stem cells and development 2004;13(1):83-92.
2004: Zhang Yanyan; Foudi Adlen; Geay Jean-François; Berthebaud Magali; Buet Dorothée; Jarrier Peggy; Jalil Abdelali; Vainchenker William; Louache Fawzia
Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells.
Stem cells (Dayton, Ohio) 2004;22(6):1015-29.
2004: Debili Najet; Louache Fawzia; Vainchenker William
Isolation and culture of megakaryocyte precursors.
Methods in molecular biology (Clifton, N.J.) 2004;272():293-308.
2003: Chagraoui Hédia; Sabri Siham; Capron Claude; Villeval Jean Luc; Vainchenker William; Wendling Françoise
Expression of osteoprotegerin mRNA and protein in murine megakaryocytes.
Experimental hematology 2003;31(11):1081-8.
2003: Laderach Diego; Compagno Daniel; Danos Olivier; Vainchenker William; Galy Anne
RNA interference shows critical requirement for NF-kappa B p50 in the production of IL-12 by human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1750-7.
2003: Lacout Catherine; Haddad Elie; Sabri Siham; Svinarchouk Fedor; Garçon Loic; Capron Claude; Foudi Adlen; Mzali Rym; Snapper Scott B; Louache Fawzia; Vainchenker William; Duménil Dominique
A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome.
Blood 2003;102(4):1282-9.
2003: Komura Emiko; Chagraoui Hédia; Mansat de Mas Véronique; Blanchet Benoit; de Sepulveda Paulo; Larbret Frédéric; Larghero Jérome; Tulliez Michel; Debili Najet; Vainchenker William; Giraudier Stéphane
Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: possible relationship with FKBP51 overexpression.
Experimental hematology 2003;31(7):622-30.
2003: Coppo Paul; Dusanter-Fourt Isabelle; Millot Gael; Nogueira Maria Manuela; Dugray Aymeric; Bonnet Marie Laure; Mitjavila-Garcia Maria Theresa; Le Pesteur Dominique; Guilhot Francosie; Vainchenker William; Sainteny Francoise; Turhan Ali G
Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.
Oncogene 2003;22(26):4102-10.
2003: Abdulkarim Bassam; Sabri Siham; Zelenika Diana; Deutsch Eric; Frascogna Valerie; Klijanienko Jerzy; Vainchenker William; Joab Irène; Bourhis Jean
Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies.
Oncogene 2003;22(15):2260-71.
2003: Chagraoui Hédia; Tulliez Micheline; Smayra Tarek; Komura Emiko; Giraudier Stéphane; Yun Theodore; Lassau Nathalie; Vainchenker William; Wendling Françoise
Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO.
Blood 2003;101(8):2983-9.
2003: Raslova Hana; Roy Lydia; Vourc'h Claire; Le Couedic Jean Pierre; Brison Olivier; Metivier Didier; Feunteun Jean; Kroemer Guido; Debili Najet; Vainchenker William
Megakaryocyte polyploidization is associated with a functional gene amplification.
Blood 2003;101(2):541-4.
2002: Sordet Olivier; Rébé Cédric; Plenchette Stéphanie; Zermati Yaël; Hermine Olivier; Vainchenker William; Garrido Carmen; Solary Eric; Dubrez-Daloz Laurence
Specific involvement of caspases in the differentiation of monocytes into macrophages.
Blood 2002;100(13):4446-53.
2002: Delhommeau François; Thierry Antoine; Feneux Danièle; Lauret Evelyne; Leclercq Edwige; Courtier Marie Hélène; Sainteny Françoise; Vainchenker William; Bennaceur-Griscelli Annelise
Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant.
Oncogene 2002;21(54):8262-71.
2002: Chagraoui Hédia; Komura Emiko; Tulliez Micheline; Giraudier Stéphane; Vainchenker William; Wendling Françoise
Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice.
Blood 2002;100(10):3495-503.
2002: Giraudier Stéphane; Chagraoui Hédia; Komura Emiko; Barnache Stéphane; Blanchet Benoit; LeCouedic Jean Pierre; Smith David F; Larbret Frédéric; Taksin Anne-Laure; Moreau-Gachelin Françoise; Casadevall Nicole; Tulliez Michel; Hulin Anne; Debili Najet; Vainchenker William
Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors.
Blood 2002;100(8):2932-40.
2002: De Botton Stephane; Sabri Siham; Daugas Eric; Zermati Yael; Guidotti Jacques Emmanuel; Hermine Olivier; Kroemer Guido; Vainchenker William; Debili Najet
Platelet formation is the consequence of caspase activation within megakaryocytes.
Blood 2002;100(4):1310-7.
2002: Norol Françoise; Drouet Michel; Pflumio Françoise; Léonardi Marjorie; Mourcin Frédéric; Debili Najet; Job Agnès; Vainchenker William; Kuentz Mathieu; Hérodin Francis
Ex vivo expansion marginally amplifies repopulating cells from baboon peripheral blood mobilized CD34+ cells.
British journal of haematology 2002;117(4):924-34.
2002: Millot Gaël A; Vainchenker William; Duménil Dominique; Svinarchuk Fédor
Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells.
Journal of cell science 2002;115(Pt 11):2329-37.
2002: Abdulkarim Bassam; Sabri Siham; Deutsch Eric; Chagraoui Heddia; Maggiorella Laurence; Thierry Jerome; Eschwege François; Vainchenker William; Chouaïb Salem; Bourhis Jean
Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers.
Oncogene 2002;21(15):2334-46.
2002: Mitjavila-Garcia Maria Teresa; Cailleret Michel; Godin Isabelle; Nogueira Maria Manuela; Cohen-Solal Karine; Schiavon Valérie; Lecluse Yann; Le Pesteur Françoise; Lagrue Anne Hélène; Vainchenker William
Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells.
Development (Cambridge, England) 2002;129(8):2003-13.
2002: Fleischman Roger A; Letestu Rémi; Mi Xiafang; Stevens David; Winters Jeffrey; Debili Najet; Vainchenker William
Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome.
British journal of haematology 2002;116(2):367-75.
2002: Filippi Marie-Dominique; Porteu Françoise; Le Pesteur Françoise; Schiavon Valérie; Millot Gaël A; Vainchenker William; de Sauvage Frédéric J; Dubart Kupperschmitt Anne; Sainteny Francoise
Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro.
Blood 2002;99(4):1174-82.
2002: Millot Gaël A; Feger Fréderic; Garçon Loic; Vainchenker William; Dumenil Dominique; Svinarchuk Fédor
MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin-mediated cell growth.
Experimental hematology 2002;30(2):166-75.
2001: Baccini V; Roy L; Vitrat N; Chagraoui H; Sabri S; Le Couedic J P; Debili N; Wendling F; Vainchenker W
Role of p21(Cip1/Waf1) in cell-cycle exit of endomitotic megakaryocytes.
Blood 2001;98(12):3274-82.
2001: Paulus J M; Levin J; Debili N; Albert A; Vainchenker W
Genesis of clone size heterogeneity in megakaryocytic and other hemopoietic colonies: the stochastic model revisited.
Experimental hematology 2001;29(11):1256-69.
2001: Chagraoui H; Giraudier S; Vainchenker W; Wendling F
Adenoviral supply of active transforming growth factor-beta1 (TGF-beta1) did not prevent lethality in transforming growth factor-beta1-knockout embryos.
European cytokine network 2001;12(4):561-7.
2001: Dugray A; Geay J F; Foudi A; Bonnet M L; Vainchenker W; Wendling F; Louache F; Turhan A G
Rapid generation of a tetracycline-inducible BCR-ABL defective retrovirus using a single autoregulatory retroviral cassette.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(10):1658-62.
2001: Scolan E L; Wendling F; Barnache S; Denis N; Tulliez M; Vainchenker W; Moreau-Gachelin F
Germ-line deletion of p53 reveals a multistage tumor progression in spi-1/PU.1 transgenic proerythroblasts.
Oncogene 2001;20(39):5484-92.
2001: Ahmed M; Dusanter-Fourt I; Dugray A; Dubrez L; Novault S; Bonnet M L; Gisselbrecht S; Varet B; Solary E; Vainchenker W; Turhan A G
BCR-ABL fails to inhibit apoptosis in U937 myelomonocytic cells expressing a carboxyl-terminal truncated STAT5.
Leukemia & lymphoma 2001;42(3):445-55.
2001: Vainchenker W
[Hematopoietic stem cells]
Thérapie 2001;56(4):379-81.
2001: Lagrue-Lak-Hal A H; Debili N; Kingbury G; Lecut C; Le Couedic J P; Villeval J L; Jandrot-Perrus M; Vainchenker W
Expression and function of the collagen receptor GPVI during megakaryocyte maturation.
The Journal of biological chemistry 2001;276(18):15316-25.
2001: Roy L; Coullin P; Vitrat N; Hellio R; Debili N; Weinstein J; Bernheim A; Vainchenker W
Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes.
Blood 2001;97(8):2238-47.
2001: Deutsch E; Dugray A; AbdulKarim B; Marangoni E; Maggiorella L; Vaganay S; M'Kacher R; Rasy S D; Eschwege F; Vainchenker W; Turhan A G; Bourhis J
BCR-ABL down-regulates the DNA repair protein DNA-PKcs.
Blood 2001;97(7):2084-90.
2001: Debili N; Robin C; Schiavon V; Letestu R; Pflumio F; Mitjavila-Garcia M T; Coulombel L; Vainchenker W
Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates.
Blood 2001;97(7):2023-30.
2001: Millot G A; Svinarchuk F; Lacout C; Vainchenker W; Dumenil D
The granulocyte colony-stimulating factor receptor supports erythroid differentiation in the absence of the erythropoietin receptor or Stat5.
British journal of haematology 2001;112(2):449-58.
2001: Bennaceur-Griscelli A; Pondarré C; Schiavon V; Vainchenker W; Coulombel L
Stromal cells retard the differentiation of CD34(+)CD38(low/neg) human primitive progenitors exposed to cytokines independent of their mitotic history.
Blood 2001;97(2):435-41.
2001: Haddad E; Zugaza J L; Louache F; Debili N; Crouin C; Schwarz K; Fischer A; Vainchenker W; Bertoglio J
The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.
Blood 2001;97(1):33-8.
2000: Filippi M D; Porteu F; Le Pesteur F; Rameau P; Nogueira M M; Debili N; Vainchenker W; de Sauvage F J; Kupperschmitt A D; Sainteny F
Embryonic stem cell differentiation to hematopoietic cells: A model to study the function of various regions of the intracytoplasmic domain of cytokine receptors in vitro.
Experimental hematology 2000;28(12):1363-72.
2000: Sirven A; Pflumio F; Zennou V; Titeux M; Vainchenker W; Coulombel L; Dubart-Kupperschmitt A; Charneau P
The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells.
Blood 2000;96(13):4103-10.
2000: Nogueira M M; Mitjavila-Garcia M T; Le Pesteur F; Filippi M D; Vainchenker W; Dubart Kupperschmitt A; Sainteny F
Regulation of Id gene expression during embryonic stem cell-derived hematopoietic differentiation.
Biochemical and biophysical research communications 2000;276(2):803-12.
2000: Jandrot-Perrus M; Busfield S; Lagrue A H; Xiong X; Debili N; Chickering T; Le Couedic J P; Goodearl A; Dussault B; Fraser C; Vainchenker W; Villeval J L
Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.
Blood 2000;96(5):1798-807.
2000: Vitrat N; Letestu R; Massé A; Lazar V; Vainchenker W; Debili N
Thromboxane synthase has the same pattern of expression as platelet specific glycoproteins during human megakaryocyte differentiation.
Thrombosis and haemostasis 2000;83(5):759-68.
2000: Norol F; Drouet M; Mathieu J; Debili N; Jouault H; Grenier N; Laplanche A; Vainchenker W; Hérodin F
Ex vivo expanded mobilized peripheral blood CD34+ cells accelerate haematological recovery in a baboon model of autologous transplantation.
British journal of haematology 2000;109(1):162-72.
2000: Issaad C; Ahmed M; Novault S; Bonnet M L; Bennardo T; Varet B; Vainchenker W; Turhan A G
Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(4):662-70.
2000: Abdulkarim B; Sabri S; Deutsch E; Vaganay S; Marangoni E; Vainchenker W; Bongrand P; Busson P; Bourhis J
Radiation-induced expression of functional Fas ligand in EBV-positive human nasopharyngeal carcinoma cells.
International journal of cancer. Journal international du cancer 2000;86(2):229-37.
2000: Letestu R; Vitrat N; Massé A; Le Couedic J P; Lazar V; Rameau P; Wendling F; Vuillier J; Boutard P; Plouvier E; Plasse M; Favier R; Vainchenker W; Debili N
Existence of a differentiation blockage at the stage of a megakaryocyte precursor in the thrombocytopenia and absent radii (TAR) syndrome.
Blood 2000;95(5):1633-41.
1999: Turhan A G; Bourhis J H; Bonnet M L; Novault S; Bayle C; Bennaceur A; Vainchenker W; Pico J L; Beaujean F
Unfractionated peripheral blood stem cell autografts and CD(34+)-enriched autografts have similar long-term culture initiating capacity in multiple myeloma.
Hematology and cell therapy 1999;41(5):197-204.
1999: Bennaceur-Griscelli A; Tourino C; Izac B; Vainchenker W; Coulombel L
Murine stromal cells counteract the loss of long-term culture-initiating cell potential induced by cytokines in CD34(+)CD38(low/neg) human bone marrow cells.
Blood 1999;94(2):529-38.
1999: Haddad E; Cramer E; Rivière C; Rameau P; Louache F; Guichard J; Nelson D L; Fischer A; Vainchenker W; Debili N
The thrombocytopenia of Wiskott Aldrich syndrome is not related to a defect in proplatelet formation.
Blood 1999;94(2):509-18.
1999: Robin C; Pflumio F; Vainchenker W; Coulombel L
Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells.
The Journal of experimental medicine 1999;189(10):1601-10.
1999: Cohen-Solal K; Vitrat N; Titeux M; Vainchenker W; Wendling F
High-level expression of Mpl in platelets and megakaryocytes is independent of thrombopoietin.
Blood 1999;93(9):2859-66.
1999: Norol F; Drouet M; Debili N; Vainchenker W; Herodin F
[Ex-vivo expansion of hematopoietic stem cells: study in the primate model]
Hematology and cell therapy 1999;41(2):75-7.
1999: Robin C; Bennaceur-Griscelli A; Louache F; Vainchenker W; Coulombel L
Identification of human T-lymphoid progenitor cells in CD34+ CD38low and CD34+ CD38+ subsets of human cord blood and bone marrow cells using NOD-SCID fetal thymus organ cultures.
British journal of haematology 1999;104(4):809-19.
1999: Rivière C; Subra F; Cohen-Solal K; Cordette-Lagarde V; Letestu R; Auclair C; Vainchenker W; Louache F
Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis.
Blood 1999;93(5):1511-23.
1999: Burstein S A; Dubart A; Norol F; Debili N; Friese P; Downs T; Yu X; Kincade P W; Villeval J L; Vainchenker W
Expression of a foreign protein in human megakaryocytes and platelets by retrovirally mediated gene transfer.
Experimental hematology 1999;27(1):110-6.
1999: Taksin A L; Couedic J P; Dusanter-Fourt I; Massé A; Giraudier S; Katz A; Wendling F; Vainchenker W; Casadevall N; Debili N
Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L.
Blood 1999;93(1):125-39.
1998: Byk T; Haddada H; Vainchenker W; Louache F
Lipofectamine and related cationic lipids strongly improve adenoviral infection efficiency of primitive human hematopoietic cells.
Human gene therapy 1998;9(17):2493-502.
1998: Turhan A G; Solary E; Vainchenker W; Dusanter-Fourt I
Molecular pathophysiology of chronic myelogenous leukemia.
Hematology and cell therapy 1998;40(5):217-21.
1998: Vainchenker W; Debili N; Norol F; Wendling F
[Thrombopoietin and megakaryocyte differentiation]
Schweizerische medizinische Wochenschrift 1998;128(42):1575-81.
1998: Wendling F; Vainchenker W
Thrombopoietin and its receptor.
European cytokine network 1998;9(3):221-31.
1998: Goncalves F; Lacout C; Féger F; Cohen-Solal K; Guichard J; Cramer E; Vainchenker W; Duménil D
Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7/c-mpl and TF-1/c-mpl cell lines.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(9):1355-66.
1998: Marandin A; Dubart A; Pflumio F; Cosset F L; Cordette V; Chapel-Fernandes S; Coulombel L; Vainchenker W; Louache F
Retrovirus-mediated gene transfer into human CD34+38low primitive cells capable of reconstituting long-term cultures in vitro and nonobese diabetic-severe combined immunodeficiency mice in vivo.
Human gene therapy 1998;9(10):1497-511.
1998: Barnache S; Wendling F; Lacombe C; Denis N; Titeux M; Vainchenker W; Moreau-Gachelin F
Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.
Oncogene 1998;16(23):2989-95.
1998: Abina M A; Tulliez M; Duffour M T; Debili N; Lacout C; Villeval J L; Wendling F; Vainchenker W; Haddada H
Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4481-9.
1998: Vitrat N; Cohen-Solal K; Pique C; Le Couedic J P; Norol F; Larsen A K; Katz A; Vainchenker W; Debili N
Endomitosis of human megakaryocytes are due to abortive mitosis.
Blood 1998;91(10):3711-23.
1998: Abina M A; Tulliez M; Lacout C; Debili N; Villeval J L; Pflumio F; Wendling F; Vainchenker W; Haddada H
Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression.
Gene therapy 1998;5(4):497-506.
1998: Mitjavila M T; Filippi M D; Cohen-Solal K; Le Pesteur F; Vainchenker W; Sainteny F
The Mpl-ligand is involved in the growth-promoting activity of the murine stromal cell line MS-5 on ES cell-derived hematopoiesis.
Experimental hematology 1998;26(2):124-34.
1998: Norol F; Vitrat N; Cramer E; Guichard J; Burstein S A; Vainchenker W; Debili N
Effects of cytokines on platelet production from blood and marrow CD34+ cells.
Blood 1998;91(3):830-43.
1998: Taskin A L; Cohen-Solal K; Le Couedic J P; Abina M A; Villeval J L; Debili N; Casadevall N; Vainchenker W; Wendling F
Myelofibrosis: experimental models and human studies.
Stem cells (Dayton, Ohio) 1998;16 Suppl 2():155-64.
1998: Vitrat N; Cohen-Solal K; Norol F; Guichard J; Cramer E; Vainchenker W; Wendling F; Debili N
Compared effects of Mpl ligand and other cytokines on human MK differentiation.
Stem cells (Dayton, Ohio) 1998;16 Suppl 2():37-51.
1998: Wendling F; Cohen-Solal K; Villeval J L; Debili N; Vainchenker W
Mpl ligand or thrombopoietin: biological activities.
Biotherapy (Dordrecht, Netherlands) 1998;10(4):269-77.
1997: Villeval J L; Cohen-Solal K; Tulliez M; Giraudier S; Guichard J; Burstein S A; Cramer E M; Vainchenker W; Wendling F
High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice.
Blood 1997;90(11):4369-83.
1997: Cohen-Solal K; Debili N; Vainchenker W; Wendling F
Thrombopoietin (Mpl ligand) and the regulation of platelet production.
European cytokine network 1997;8(3):311-4.
1997: Cohen-Solal K; Debili N; Vainchenker W; Wendling F
Thrombopoietin (Mpl-ligand) and the regulation of platelet production.
Thrombosis and haemostasis 1997;78(1):37-41.
1997: Berardi A C; Meffre E; Pflumio F; Katz A; Vainchenker W; Schiff C; Coulombel L
Individual CD34+CD38lowCD19-CD10- progenitor cells from human cord blood generate B lymphocytes and granulocytes.
Blood 1997;89(10):3554-64.
1997: Goncalves F; Lacout C; Villeval J L; Wendling F; Vainchenker W; Dumenil D
Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation.
Blood 1997;89(10):3544-53.
1997: Cramer E M; Norol F; Guichard J; Breton-Gorius J; Vainchenker W; Massé J M; Debili N
Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand.
Blood 1997;89(7):2336-46.
1997: Pignon J M; Giraudier S; Duquesnoy P; Jouault H; Imbert M; Vainchenker W; Vernant J P; Tulliez M
A new c-kit mutation in a case of aggressive mast cell disease.
British journal of haematology 1997;96(2):374-6.
1997: Féger F; Dubart A; Lacout C; Dusanter-Fourt I; Mayeux P; Vainchenker W; Duménil D
Ectopic expression of the erythropoietin receptor in a murine interleukin-6-dependent plasmacytoma cell line (TEPC-2027) confers proliferative responsiveness to erythropoietin.
Blood 1997;89(2):435-45.
1996: Marandin A; Katz A; Oksenhendler E; Tulliez M; Picard F; Vainchenker W; Louache F
Loss of primitive hematopoietic progenitors in patients with human immunodeficiency virus infection.
Blood 1996;88(12):4568-78.
1996: Pflumio F; Izac B; Katz A; Shultz L D; Vainchenker W; Coulombel L
Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells.
Blood 1996;88(10):3731-40.
1996: Cohen-Solal K; Villeval J L; Titeux M; Lok S; Vainchenker W; Wendling F
Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.
Blood 1996;88(7):2578-84.
1996: Goncalves F; Dubart A; Lacout C; Vainchenker W; Duménil D
Stromal cells maintain the radioprotective capacity of CFU-S during retroviral infection.
Gene therapy 1996;3(9):761-8.
1996: Auffray I; Chevalier S; Froger J; Izac B; Vainchenker W; Gascan H; Coulombel L
Nerve growth factor is involved in the supportive effect by bone marrow--derived stromal cells of the factor-dependent human cell line UT-7.
Blood 1996;88(5):1608-18.
1996: Debili N; Coulombel L; Croisille L; Katz A; Guichard J; Breton-Gorius J; Vainchenker W
Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow.
Blood 1996;88(4):1284-96.
1996: Dubart A; Roméo P H; Vainchenker W; Dumenil D
Constitutive expression of GATA-1 interferes with the cell-cycle regulation.
Blood 1996;87(9):3711-21.
1996: Hermine O; Dubart A; Porteux F; Mayeux P; Titeux M; Dumenil D; Vainchenker W
Inhibition of the erythropoietin-induced erythroid differentiation by granulocyte-macrophage colony-stimulating factor in the human UT-7 cell line is not due to a negative regulation of the erythropoietin receptor.
Blood 1996;87(5):1746-53.
1996: Le Couedic J P; Mitjavila M T; Villeval J L; Feger F; Gobert S; Mayeux P; Casadevall N; Vainchenker W
Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies.
Blood 1996;87(4):1502-11.
1996: Lacout C; Dubart A; Vainchenker W; Duménil D
Pluripotent stem cells constitutively expressing a normal erythropoietin receptor give rise to normal hematopoiesis in lethally irradiated recipient mice.
Experimental hematology 1996;24(1):18-25.
1996: Wendling F; Cohen-Solal K; Debili N; Villeval J L; Titeux M; Vainchenker W
[Mpl ligand (thrombopoietin) and platelet regulation]
Annales pharmaceutiques françaises 1996;54(4):177-82.
1995: Huyhn A; Dommergues M; Izac B; Croisille L; Katz A; Vainchenker W; Coulombel L
Characterization of hematopoietic progenitors from human yolk sacs and embryos.
Blood 1995;86(12):4474-85.
1995: Debili N; Wendling F; Katz A; Guichard J; Breton-Gorius J; Hunt P; Vainchenker W
The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors.
Blood 1995;86(7):2516-25.
1995: Marandin A; Canque B; Coulombel L; Gluckman J C; Vainchenker W; Louache F
In vitro infection of bone marrow-adherent cells by human immunodeficiency virus type 1 (HIV-1) does not alter their ability to support hematopoiesis.
Virology 1995;213(1):245-8.
1995: Wendling F; Vainchenker W
Thrombopoietin and its receptor, the proto-oncogene c-mpl.
Current opinion in hematology 1995;2(5):331-8.
1995: Bierling P; Godeau B; Fromont P; Bettaieb A; Debili N; el-Kassar N; Rouby J J; Vainchenker W; Duedari N
Posttransfusion purpura-like syndrome associated with CD36 (Naka) isoimmunization.
Transfusion 1995;35(9):777-82.
1995: Vainchenker W; Debili N; Mouthon M A; Wendling F
Megakaryocytopoiesis: cellular aspects and regulation.
Critical reviews in oncology/hematology 1995;20(1-2):165-92.
1995: Vainchenker W; Methia N; Debili N; Titeux M; Wendling F
c-mpl, the thrombopoietin receptor.
Thrombosis and haemostasis 1995;74(1):526-8.
1995: Kobari L; Dubart A; Le Pesteur F; Vainchenker W; Sainteny F
Hematopoietic-promoting activity of the murine stromal cell line MS-5 is not related to the expression of the major hematopoietic cytokines.
Journal of cellular physiology 1995;163(2):295-304.
1995: Canque B; Marandin A; Rosenzwajg M; Louache F; Vainchenker W; Gluckman J C
Susceptibility of human bone marrow stromal cells to human immunodeficiency virus (HIV).
Virology 1995;208(2):779-83.
1995: Naffakh N; Henri A; Villeval J L; Rouyer-Fessard P; Moullier P; Blumenfeld N; Danos O; Vainchenker W; Heard J M; Beuzard Y
Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3194-8.
1995: Breton-Gorius J; Favier R; Guichard J; Cherif D; Berger R; Debili N; Vainchenker W; Douay L
A new congenital dysmegakaryopoietic thrombocytopenia (Paris-Trousseau) associated with giant platelet alpha-granules and chromosome 11 deletion at 11q23.
Blood 1995;85(7):1805-14.
1995: Methia N; Debili N; Titeux M; Vainchenker W; Wendling F
From the v-mpl oncogene to thrombopoietin.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1995;318(4):479-82.
1994: Croisille L; Auffray I; Katz A; Izac B; Vainchenker W; Coulombel L
Hydrocortisone differentially affects the ability of murine stromal cells and human marrow-derived adherent cells to promote the differentiation of CD34++/CD38- long-term culture-initiating cells.
Blood 1994;84(12):4116-24.
1994: Issaad C; Vainchenker W
Growth of erythroid colonies in chronic myelogenous leukemia is independent of erythropoietin only in the presence of steel factor.
Blood 1994;84(10):3447-56.
1994: Louache F; Debili N; Marandin A; Coulombel L; Vainchenker W
Expression of CD4 by human hematopoietic progenitors.
Blood 1994;84(10):3344-55.
1994: Villeval J L; Mitjavila M T; Dusanter-Fourt I; Wendling F; Mayeux P; Vainchenker W
Autocrine stimulation by erythropoietin (Epo) requires Epo secretion.
Blood 1994;84(8):2649-62.
1994: Louache F; Vainchenker W
Thrombocytopenia in HIV infection.
Current opinion in hematology 1994;1(5):369-72.
1994: Villeval J L; Rouyer-Fessard P; Blumenfeld N; Henri A; Vainchenker W; Beuzard Y
Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia.
Blood 1994;84(3):928-33.
1994: Descamps V; Blumenfeld N; Villeval J L; Vainchenker W; Perricaudet M; Beuzard Y
Erythropoietin gene transfer and expression in adult normal mice: use of an adenovirus vector.
Human gene therapy 1994;5(8):979-85.
1994: Mouthon M A; Freund M; Titeux M; Katz A; Guichard J; Breton-Gorius J; Vainchenker W
Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis.
Blood 1994;84(4):1085-97.
1994: Dubart A; Feger F; Lacout C; Goncalves F; Vainchenker W; Dumenil D
Murine pluripotent hematopoietic progenitors constitutively expressing a normal erythropoietin receptor proliferate in response to erythropoietin without preferential erythroid cell differentiation.
Molecular and cellular biology 1994;14(7):4834-42.
1994: Wendling F; Maraskovsky E; Debili N; Florindo C; Teepe M; Titeux M; Methia N; Breton-Gorius J; Cosman D; Vainchenker W
cMpl ligand is a humoral regulator of megakaryocytopoiesis.
Nature 1994;369(6481):571-4.
1994: Vainchenker W; Debili N; Methia N; Mouthon M A; Wendling F
[Hematopoiesis and its regulation. Comparison between erythropoiesis and megakaryocytopoiesis]
Bulletin de l'Académie nationale de médecine 1994;178(5):753-78; discussion 778-9.
1994: Auffray I; Dubart A; Izac B; Vainchenker W; Coulombel L
A murine stromal cell line promotes the proliferation of the human factor-dependent leukemic cell line UT-7.
Experimental hematology 1994;22(5):417-24.
1994: Mouthon M A; Mitjavila M T; Marquet J; Vainchenker W; Wendling F
Erroneous results of 3H-thymidine incorporation are related to position of thymidine residues in oligodeoxynucleotides.
Experimental hematology 1994;22(4):384-7.
1994: Bierling P; Pignon J M; Kuentz M; Mitjavila M T; Fromont P; Barbu V; Goossens M; Duedari N; Vainchenker W; Vernant J P
Thrombocytopenia after bone marrow transplantation caused by a recipient origin Br(a) allo-antibody: presence of mixed chimerism 3 years after the graft without hematologic relapse.
Blood 1994;83(1):274-9.
1993: Mayeux P; Dusanter-Fourt I; Muller O; Mauduit P; Sabbah M; Druker B; Vainchenker W; Fischer S; Lacombe C; Gisselbrecht S
Erythropoietin induces the association of phosphatidylinositol 3'-kinase with a tyrosine-phosphorylated protein complex containing the erythropoietin receptor.
European journal of biochemistry / FEBS 1993;216(3):821-8.
1993: Methia N; Louache F; Vainchenker W; Wendling F
Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis.
Blood 1993;82(5):1395-401.
1993: Debili N; Massé J M; Katz A; Guichard J; Breton-Gorius J; Vainchenker W
Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells.
Blood 1993;82(1):84-95.
1993: Saadane N; Rouyer-Fessard P; Villeval J L; Blumenfeld-Charbit N; Henri A; Leroy-Viard K; Sauvage C; Vicaut E; Maurel A; Vainchenker W
[Physiopathologic and therapeutic importance of animal models of hemoglobinopathies]
Nouvelle revue française d'hématologie 1993;35(3):301-2.
1993: Casadevall N; Vainchenker W
[Erythropoiesis and its regulation]
La Revue du praticien 1993;43(11):1335-40.
1993: Vainchenker W
[Regulation of erythropoiesis]
Nouvelle revue française d'hématologie 1993;35(3):309-12.
1993: Issaad C; Croisille L; Katz A; Vainchenker W; Coulombel L
A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38- progenitor cells in long-term cultures and semisolid assays.
Blood 1993;81(11):2916-24.
1993: Fermand J P; Mitjavila M T; Le Couedic J P; Tsapis A; Berger R; Modigliani R; Seligmann M; Brouet J C; Vainchenker W
Role of granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5 in the eosinophilia associated with T cell lymphoma.
British journal of haematology 1993;83(3):359-64.
1993: Mouthon M A; Bernard O; Mitjavila M T; Romeo P H; Vainchenker W; Mathieu-Mahul D
Expression of tal-1 and GATA-binding proteins during human hematopoiesis.
Blood 1993;81(3):647-55.
1992: Hermine O; Mayeux P; Titeux M; Mitjavila M T; Casadevall N; Guichard J; Komatsu N; Suda T; Miura Y; Vainchenker W
Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7.
Blood 1992;80(12):3060-9.
1992: Debili N; Issaad C; Massé J M; Guichard J; Katz A; Breton-Gorius J; Vainchenker W
Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation.
Blood 1992;80(12):3022-35.
1992: Louache F; Henri A; Bettaieb A; Oksenhendler E; Raguin G; Tulliez M; Vainchenker W
Role of human immunodeficiency virus replication in defective in vitro growth of hematopoietic progenitors.
Blood 1992;80(12):2991-9.
1992: Mouthon M A; Navarro S; Katz A; Breton-Gorius J; Vainchenker W
c-jun and c-fos are expressed by human megakaryocytes.
Experimental hematology 1992;20(7):909-15.
1992: Bettaieb A; Fromont P; Louache F; Oksenhendler E; Vainchenker W; Duédari N; Bierling P
Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura.
Blood 1992;80(1):162-9.
1992: Breton-Gorius J; Clezardin P; Guichard J; Debili N; Malaval L; Vainchenker W; Cramer E M; Delmas P D
Localization of platelet osteonectin at the internal face of the alpha-granule membranes in platelets and megakaryocytes.
Blood 1992;79(4):936-41.
1992: Debili N; Breton-Gorius J; Vainchenker W
Hematopoietic growth factors and human megakaryocyte differentiation.
Bone marrow transplantation 1992;9 Suppl 1():11-5.
1991: Louache F; Bettaieb A; Henri A; Oksenhendler E; Farcet J P; Bierling P; Seligmann M; Vainchenker W
Infection of megakaryocytes by human immunodeficiency virus in seropositive patients with immune thrombocytopenic purpura.
Blood 1991;78(7):1697-705.
1991: Mitjavila M T; Le Couedic J P; Casadevall N; Navarro S; Villeval J L; Dubart A; Vainchenker W
Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro.
The Journal of clinical investigation 1991;88(3):789-97.
1991: Debili N; Hegyi E; Navarro S; Katz A; Mouthon M A; Breton-Gorius J; Vainchenker W
In vitro effects of hematopoietic growth factors on the proliferation, endoreplication, and maturation of human megakaryocytes.
Blood 1991;77(11):2326-38.
1991: Hegyi E; Nakazawa M; Debili N; Navarro S; Katz A; Breton-Gorius J; Vainchenker W
Developmental changes in human megakaryocyte ploidy.
Experimental hematology 1991;19(2):87-94.
1991: Navarro S; Debili N; Le Couedic J P; Klein B; Breton-Gorius J; Doly J; Vainchenker W
Interleukin-6 and its receptor are expressed by human megakaryocytes: in vitro effects on proliferation and endoreplication.
Blood 1991;77(3):461-71.
1991: Louache F; Debili N; Cramer E; Breton-Gorius J; Vainchenker W
Fibrinogen is not synthesized by human megakaryocytes.
Blood 1991;77(2):311-6.
1991: Breton-Gorius J; Vuillet-Gaugler M H; Coulombel L; Guichard J; Teillet F; Vainchenker W
Association between leukemic erythroid progenitors and bone marrow macrophages.
Blood cells 1991;17(1):127-42; discussion 142-6.
1990: Hegyi E; Navarro S; Debili N; Mouthon M A; Katz A; Breton-Gorius J; Vainchenker W
Regulation of human megakaryocytopoiesis: analysis of proliferation, ploidy and maturation in liquid cultures.
International journal of cell cloning 1990;8(4):236-44.
1990: Debili N; Kieffer N; Nakazawa M; Guichard J; Titeux M; Cramer E; Breton-Gorius J; Vainchenker W
Expression of platelet glycoprotein Ib by cultured human megakaryocytes: ultrastructural localization and biosynthesis.
Blood 1990;76(2):368-76.
1990: Navarro S; Louache F; Debili N; Vainchenker W; Doly J
Autocrine regulation of terminal differentiation by interleukin-6 in the pluripotent KU812 cell line.
Biochemical and biophysical research communications 1990;169(1):184-91.
1990: Levy Y; Fermand J P; Navarro S; Schmitt C; Vainchenker W; Seligmann M; Brouet J C
Interleukin 6 dependence of spontaneous in vitro differentiation of B cells from patients with IgM gammapathy.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3309-13.
1990: Romeo P H; Prandini M H; Joulin V; Mignotte V; Prenant M; Vainchenker W; Marguerie G; Uzan G
Megakaryocytic and erythrocytic lineages share specific transcription factors.
Nature 1990;344(6265):447-9.
1990: Vuillet-Gaugler M H; Breton-Gorius J; Vainchenker W; Guichard J; Leroy C; Tchernia G; Coulombel L
Loss of attachment to fibronectin with terminal human erythroid differentiation.
Blood 1990;75(4):865-73.
1990: Cramer E M; Harrison P; Savidge G F; Wilbourn B; Debili N; Vainchenker W; Breton-Gorius J
Uncoordinated expression of alpha-granule proteins in human megakaryocytes.
Progress in clinical and biological research 1990;356():131-42.
1989: Le Van Kim C; Colin Y; Mitjavila M T; Clerget M; Dubart A; Nakazawa M; Vainchenker W; Cartron J P
Structure of the promoter region and tissue specificity of the human glycophorin C gene.
The Journal of biological chemistry 1989;264(34):20407-14.
1989: Harrison P; Wilbourn B; Debili N; Vainchenker W; Breton-Gorius J; Lawrie A S; Masse J M; Savidge G F; Cramer E M
Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets.
The Journal of clinical investigation 1989;84(4):1320-4.
1989: Mariette X; Mitjavila M T; Moulinie J P; Bussel A; Brouet J C; Vainchenker W; Fermand J P
Rifampicin-induced pure red cell aplasia.
The American journal of medicine 1989;87(4):459-60.
1989: Debili N; Kieffer N; Mitjavila M T; Villeval J L; Guichard J; Teillet F; Henri A; Clemetson K J; Vainchenker W; Breton-Gorius J
Expression of platelet glycoproteins by erythroid blasts in four cases of trisomy 21.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1989;3(9):669-78.
1989: Kieffer N; Bettaieb A; Legrand C; Coulombel L; Vainchenker W; Edelman L; Breton-Gorius J
Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor.
The Biochemical journal 1989;262(3):835-42.
1989: Caubet J F; Mitjavila M T; Dubart A; Roten D; Weil S C; Vainchenker W
Expression of the c-fos protooncogene by human and murine erythroblasts.
Blood 1989;74(3):947-51.
1989: Navarro S; Debili N; Bernaudin J F; Vainchenker W; Doly J
Regulation of the expression of IL-6 in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4339-45.
1989: Villeval J L; Le Van Kim C; Bettaieb A; Debili N; Colin Y; el Maliki B; Blanchard D; Vainchenker W; Cartron J P
Early expression of glycophorin C during normal and leukemic human erythroid differentiation.
Cancer research 1989;49(10):2626-32.
1989: Mitjavila M T; Natazawa M; Brignaschi P; Debili N; Breton-Gorius J; Vainchenker W
Effects of five recombinant hematopoietic growth factors on enriched human erythroid progenitors in serum-replaced cultures.
Journal of cellular physiology 1989;138(3):617-23.
1989: Breton-Gorius J; Villeval J L; Kieffer N; Mitjavila M T; Guichard J; Vainchenker W
Limits of phenotypic markers for the diagnosis of megakaryoblastic leukemia.
Blood cells 1989;15(1):259-77.
1988: Vinci G; Vernant J P; Nakazawa M; Zohair M; Katz A; Henri A; Rochant H; Breton-Gorius J; Vainchenker W
In vitro inhibition of normal human hematopoiesis by marrow CD3+, CD8+, HLA-DR+, HNK1+ lymphocytes.
Blood 1988;72(5):1616-21.
1988: Farace F; Mitjavila M T; Betaieb A; Dokhelar M C; Wiels J; Finale Y; Kieffer N; Breton-Gorius J; Vainchenker W; Tursz T
New hematopoietic differentiation antigens detected by anti-K562 monoclonal antibodies.
Cancer research 1988;48(20):5759-65.
1988: Kieffer N; Wautier J L; Coulombel L; Titeux M; Wautier M P; Vainchenker W; Ruan C; Breton-Gorius J
Uncoupling in the expression of platelet GP IIb/IIIa in human endothelial cells and K562 cells: absence of immunologic crossreactivity between platelet GP IIb and the vitronectin receptor alpha chain.
Blood 1988;72(4):1209-15.
1988: Max-Audit I; Kechemir D; Mitjavila M T; Vainchenker W; Rotten D; Rosa R
Pyruvate kinase synthesis and degradation by normal and pathologic cells during erythroid maturation.
Blood 1988;72(3):1039-44.
1988: Vainchenker W; Kieffer N
Human megakaryocytopoiesis: in vitro regulation and characterization of megakaryocytic precursor cells by differentiation markers.
Blood reviews 1988;2(2):102-7.
1988: Vainchenker W; Villeval J L; Tabilio A; Matamis H; Karianakis G; Guichard J; Henri A; Vernant J P; Rochant H; Breton-Gorius J
Immunophenotype of leukemic blasts with small peroxidase-positive granules detected by electron microscopy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(5):274-81.
1988: Bettaieb A; Farace F; Mitjavila M T; Mishal Z; Dokhelar M C; Tursz T; Breton-Gorius J; Vainchenker W; Kieffer N
Use of a monoclonal antibody (GA3) to demonstrate lineage restricted O-glycosylation on leukosialin during terminal erythroid differentiation.
Blood 1988;71(5):1226-33.
1988: Mitjavila M T; Vinci G; Villeval J L; Kieffer N; Henri A; Testa U; Breton-Gorius J; Vainchenker W
Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta).
Journal of cellular physiology 1988;134(1):93-100.
1987: Bettaieb A; Villeval J L; Kieffer N; Farace F; Edelman L; Cartron J P; Vainchenker W
Early erythroid markers as probes for normal and leukaemic erythroid differentiation.
Annales de l'Institut Pasteur. Immunology 1987;138(6):877-83.
1987: Mitjavila M T; Villeval J L; Cramer P; Henri A; Gasson J; Krystal G; Tulliez M; Berger R; Breton-Gorius J; Vainchenker W
Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias.
Blood 1987;70(4):965-73.
1987: Cramer P; Vainchenker W; Brouet J C; Berger R
Cytogenetic study of myeloid and erythroid colonies in chronic myeloid leukaemia with stable Ph1 mosaicism.
British journal of haematology 1987;67(1):51-4.
1987: Breton-Gorius J; Villeval J L; Mitjavila M T; Vinci G; Guichard J; Rochant H; Flandrin G; Vainchenker W
Ultrastructural and cytochemical characterization of blasts from early erythroblastic leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(3):173-81.
1987: Breton-Gorius J; Lewis J C; Guichard J; Kieffer N; Vainchenker W
Monoclonal antibodies specific for human platelet membrane glycoproteins bind to monocytes by focal absorption of platelet membrane fragments: an ultrastructural immunogold study.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(2):131-41.
1987: Tulliez M; Villeval J L; Lejeune F; Henri A; Testa U; Titeux M; Rochant H; Breton-Gorius J; Vainchenker W
Expression of blood group A antigen during erythroid differentiation in A1 and A2 subjects.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(1):44-51.
1987: Vinci G; Vernant J P; Cordonnier C; Henri A; Breton-Gorius J; Rochant H; Vainchenker W
In vitro inhibition of hematopoiesis by HNK1, DR-positive T cells and monocytes after allogeneic bone marrow transplantation.
Experimental hematology 1987;15(1):54-64.
1986: Edelman P; Vinci G; Villeval J L; Vainchenker W; Henri A; Miglierina R; Rouger P; Reviron J; Breton-Gorius J; Sureau C
A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors.
Blood 1986;67(1):56-63.
1986: Vainchenker W; Kieffer N; Cramer E; Vinci G; Debili N; Henri A; Titeux M; Guichard J; Mishal Z; Breton-Gorius J
Expression of platelet proteins during maturation of human megakaryocytes and of the K 562/HEL cell lines.
Progress in clinical and biological research 1986;215():227-40.
1985: Cramer E M; Vainchenker W; Vinci G; Guichard J; Breton-Gorius J
Gray platelet syndrome: immunoelectron microscopic localization of fibrinogen and von Willebrand factor in platelets and megakaryocytes.
Blood 1985;66(6):1309-16.
1985: Vainchenker W; Vinci G; Testa U; Henri A; Tabilio A; Fache M P; Rochant H; Cartron J P
Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome.
The Journal of clinical investigation 1985;75(2):541-6.
1984: Max-Audit I; Testa U; Kechemir D; Titeux M; Vainchenker W; Rosa R
Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts.
Blood 1984;64(4):930-6.
1984: Vinci G; Tabilio A; Deschamps J F; Van Haeke D; Henri A; Guichard J; Tetteroo P; Lansdorp P M; Hercend T; Vainchenker W
Immunological study of in vitro maturation of human megakaryocytes.
British journal of haematology 1984;56(4):589-605.
1984: Tabilio A; Vainchenker W; Van Haecke D; Vinci G; Guichard J; Henri A; Reyes F; Breton-Gorius J
Immunological characterization of the leukemic megakaryocytic line at light and electron microscopic levels.
Leukemia research 1984;8(5):769-81.
1983: Breton-Gorius J; Tabilio A; Vainchenker W; Vinci G; van Haeke D; Henri A; Guichard J; Canizo M C
Diagnosis of megakaryoblastic leukemias.
Verhandlungen der Deutschen Gesellschaft für Pathologie 1983;67():166-81.
1983: Breton-Gorius J; Vanhaeke D; Tabilio A; Vainchenker W; Deschamps J F; Xu F S
Glycoprotein I identification during normal and pathological megakaryocytic maturation.
Blood cells 1983;9(2):275-91.
1982: Testa U; Henri A; Bettaieb A; Titeux M; Vainchenker W; Tonthat H; Docklear M C; Rochant H
Regulation of i- and I-antigen expression in the K562 cell line.
Cancer research 1982;42(11):4694-700.
1982: Vainchenker W; Chapman J; Deschamps J F; Vinci G; Bouguet J; Titeux M; Breton-Gorius J
Normal human serum contains a factor(s) capable of inhibiting megakaryocyte colony formation.
Experimental hematology 1982;10(8):650-60.
1982: Testa U; Thomopoulos P; Vinci G; Titeux M; Bettaieb A; Vainchenker W; Rochant H
Transferrin binding to K562 cell line. Effect of heme and sodium butyrate induction.
Experimental cell research 1982;140(2):251-60.
1982: Vainchenker W; Guichard J; Deschamps J F; Bouguet J; Titeux M; Chapman J; McMichael A J; Breton-Gorius J
Megakaryocyte cultures in the chronic phase and in the blast crisis of chronic myeloid leukaemia: studies on the differentiation of the megakaryocyte progenitors and on the maturation of megakaryocytes in vitro.
British journal of haematology 1982;51(1):131-46.
1982: Vainchenker W; Testa U; Deschamps J F; Henri A; Titeux M; Breton-Gorius J; Rochant H; Lee D; Cartron J P
Clonal expression of the Tn antigen in erythroid and granulocyte colonies and its application to determination of the clonality of the human megakaryocyte colony assay.
The Journal of clinical investigation 1982;69(5):1081-91.
1982: Vainchenker W; Deschamps J F; Bastin J M; Guichard J; Titeux M; Breton-Gorius J; McMichael A J
Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients.
Blood 1982;59(3):514-21.
1982: Testa U; Vainchenker W; Beuzard Y; Rouyer-Fessard P; Guerrasio A; Titeux M; Lapotre P; Bouguet J; Breton-Gorius J; Rosa J
Hemoglobin expression in clones of K562 cell line.
European journal of biochemistry / FEBS 1982;121(3):649-55.
1982: Dokhelar M C; Testa U; Vainchenker W; Finale Y; Tetaud C; Salem P; Tursz T
NK cell sensitivity of the leukemic K 562 cells; effect of sodium butyrate and hemin induction.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(1):211-6.
1982: Testa U; Vainchenker W; Beuzard Y; Rouyer-Fessard P; Titeux M; Bouguet J; Breton-Gorius J; Rosa J
Hemoglobin expression in clones of K-562 cell line.
Birth defects original article series 1982;18(7):117-30.
1981: Testa U; Henri A; Vainchenker W; Tonthat H; Riou J; Beuzard Y; Rochant H; Rosa J
F-cells are preferentially distributed among high density erythrocytes.
Biomedicine / [publiée pour l'A.A.I.C.I.G.] 1981;35(3):94-7.
1981: Tsapis A; Hinard N; Testa U; Dubart A; Vainchenker W; Rouyer-Fessard P; Beuzard Y; Rosa J
Study of hemoglobin synthesis by affinity chromatography on Sepharose haptoglobin.
Progress in clinical and biological research 1981;60():95-114.
1981: Beuzard Y; Tulliez M; Testa U; Vainchenker W; Dubart A; Tsapis A; Galacteros F; Breton-Gorius J; Rosa J
Beta-thalassemia and sickle cell disease in culture of early erythroid precursors: hemoglobin synthesis and ultrastructural study.
Blood cells 1981;7(1):179-200.
1981: Vainchenker W; Testa U; Rochant H; Titeux M; Henri A; Bouguet J; Breton-Gorius J
Cellular regulation of i and I antigen expressions in human erythroblasts grown in vitro.
Stem cells 1981;1(2):97-110.
1981: Feuilhade F; Testa U; Vainchenker W; Henri A; That H T; Beuzard Y; Galacteros F; Dreyfus B; Rochant H
Comparative patterns of i-antigen expression, F-cell frequency and Hb A2 level in acute myeloid leukemia and in acute lymphoid leukemia.
Leukemia research 1981;5(3):203-13.
1980: Tsapis A; Hinard N; Testa U; Dubart A; Vainchenker W; Rouyer-Fessard P; Beuzard Y; Rosa J
Globin-chain affinity chromatography on Sepharose-haptoglobin: a new method of study of hemoglobin synthesis in reticulocytes, in bone marrow and in colonies of erythroid precursors.
European journal of biochemistry / FEBS 1980;112(3):513-9.
1980: Vainchenker W; Guichard J; Bouguet J; Breton-Gorius J
Congenital dyserythropoietic anaemia type I: absence of clonal expression in the nuclear abnormalities of cultured erythroblasts.
British journal of haematology 1980;46(1):33-7.
1980: Vainchenker W; Breton-Gorius J; Guichard J; Bouguet J; Henri A; Rochant H; Goudsmit R
Congenital dyserythropoietic anemia type III. studies on erythroid differentiation of blood erythroid progenitor cells (BFUE) in vitro.
Experimental hematology 1980;8(8):1057-62.
1980: Rochant H; Testa U; Vainchenker W; Henri A; Titeux M; Tonthat H; Feuilhade F
[Cellular regulation of the expression of i and I antigens during the in vitro differentiation of BFU-E]
Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles 1980;291(2):229-32.
1980: Vainchenker W; Dubart A; Bouguet J; Testa U; Tsapis A; Tonthat H; Henri A; Monplaisir N; Beuzard Y; Rochant H; Rosa J
Fetal hemoglobin synthesis in culture of early erythroid precursors (BFU-E) from the blood of normal adults.
Journal of cellular physiology 1980;102(3):297-303.
1980: Henri A; Testa U; Tonthat H; Riou J; Titeux M; Vainchenker W; Feuilhade F; Galacteros F; Rochant H
Disappearance of Hb F and i antigen during the first year of life.
American journal of hematology 1980;9(2):161-70.
1980: Testa U; Dubart A; Hinard N; Galacteros F; Vainchenker W; Rouyer-Fessard P; Beuzard Y; Rosa J
Beta O-thalassemia/Hb E association. Hemoglobin synthesis in blood reticulocytes and bone marrow cells fractionated by density gradient and in blood erythroid colonies in culture.
Acta haematologica 1980;64(1):42-52.
1980: Vainchenker W; Testa U; Hinard N; Beuzard Y; Dubart A; Tsapis A; Monplaisir N; Rouyer-Fessard P; Rosa J
Hemoglobin synthesis in 7-day and 14-day-old erythroid colonies from the bone marrow of normal individuals.
Hemoglobin 1980;4(1):53-67.

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