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William Vainchenker

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Sébastien Malinge; Thomas Mercher; Clarisse Thiollier; William Vainchenker; Susan M. Winandy; Philippe Dessen; Lauren Diebold; Lou Dore; Vinciane Mabialah; Olivier Bluteau; Timothy M Chlon; John D Crispino
Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.
Raphaël Itzykson; Olivier Kosmider; Guillaume Meurice; Margot Morabito; Cédric Oréar; Uwe Platzbecker; Claude Preudhomme; Philippe Rameau; Aline Renneville; Lionel Adès; Olivier A Bernard; Céline Berthon; François Delhommeau; Nathalie M Droin; Pierre Fenaux; Michaëla Fontenay; Olivier Gagey; William Vainchenker; Eric Solary
Clonal architecture of chronic myelomonocytic leukemias.
Larissa Lordier; Valeria Naim; Jiajia Pan; Philippe Rameau; Filippo Rosselli; William Vainchenker; Idinath Badirou; Najet Debili; Abdelali Jalil; Jerôme Larghero; Yunhua Chang
Presence of a defect in karyokinesis during megakaryocyte endomitosis.

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All Publications

2013: Sébastien Malinge; Thomas Mercher; Clarisse Thiollier; William Vainchenker; Susan M. Winandy; Philippe Dessen; Lauren Diebold; Lou Dore; Vinciane Mabialah; Olivier Bluteau; Timothy M Chlon; John D Crispino
Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.
Blood 2013;121(13):2440-51.
2013: Raphaël Itzykson; Olivier Kosmider; Guillaume Meurice; Margot Morabito; Cédric Oréar; Uwe Platzbecker; Claude Preudhomme; Philippe Rameau; Aline Renneville; Lionel Adès; Olivier A Bernard; Céline Berthon; François Delhommeau; Nathalie M Droin; Pierre Fenaux; Michaëla Fontenay; Olivier Gagey; William Vainchenker; Eric Solary
Clonal architecture of chronic myelomonocytic leukemias.
Blood 2013;121(12):2186-98.
2012: Larissa Lordier; Valeria Naim; Jiajia Pan; Philippe Rameau; Filippo Rosselli; William Vainchenker; Idinath Badirou; Najet Debili; Abdelali Jalil; Jerôme Larghero; Yunhua Chang
Presence of a defect in karyokinesis during megakaryocyte endomitosis.
Cell cycle (Georgetown, Tex.) 2012;11(23):4385-9.
2012: Clarisse Thiollier; William Vainchenker; Qiang Wen; Arnaud Petit; Françoise Pflumio; Sandrine Poglio; Isabelle Radford; Dirk Reinhardt; Paola Rivera-Munoz; Paola Ballerini; Anne-Laure Bauchet; Olivier A Bernard; Olivier Bluteau; Beat Bornhauser; Jean-Pierre Bourquin; John D Crispino; Nicole Dastugue; Stéphane de Botton; Philippe Dessen; M'boyba Diop; Yannis Duffourd; Daniel Gautheret; Bastien Gerby; Justine Guégan; Cathy Ignacimouttou; Judith Landman-Parker; Yann Lecluse; Cécile K Lopez; Vinciane Mabialah; Thomas Mercher
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
The Journal of experimental medicine 2012;209(11):2017-31.
2012: Dominique Bluteau; Najet Debili; Remi Favier; Laure Gilles; Ana C Glembotsky; Paula G Heller; Paquita Nurden; Anna Raimbault; Philippe Rameau; Marie Christine Alessi; Nathalie Balayn; William Vainchenker; Hana Raslova
Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression.
Blood 2012;120(13):2708-18.
2012: Iléana Antony-Debré; Véronique Baccini; Dominique Bluteau; Françoise Boehlen; Yunhua Chang; Caroline Deswarte; Nathalie M Droin; Remi Favier; Raphael Itzykson; Guy Leverger; Margot Morabito; Aline Renneville; Eric Solary; William Vainchenker; Hana Raslova
MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.
Blood 2012;120(13):2719-22.
2012: Christian Pecquet; Yohan Royer; Judith Staerk; William Vainchenker; Jean-Luc Villeval; Rodolphe Besancenot; Pierre J Courtoy; Jean-Philippe Defour; Carmen C Diaconu; Alexandra Dusa; Michael Girardot; Stéphane Giraudier; Laurent Knoops; Caroline Marty; Stefan N Constantinescu
Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.
Blood 2012;119(20):4625-35.
2012: Thomas Mercher; Cyril Quivoron; William Vainchenker; Christian Bastard; Lucile Couronné; Olivier A Bernard
TET2, a tumor suppressor in hematological disorders.
Biochimica et biophysica acta 2012;1825(2):173-7.
2012: Stefan N Constantinescu; William Vainchenker
Small-molecule inhibitors in myeloproliferative neoplasms: are we aiming for the right targets?
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2012;2012():553-60.
2012: Larissa Lordier; Thomas Mercher; Jiajia Pan; Philippe Rameau; Hana Raslova; William Vainchenker; Najet Debili; Christian Gachet; Abdelali Jalil; Dima Jouni; Céline Legrand; Catherine Leon; Dominique Bluteau; Olivier Bluteau; Yunhua Chang
RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization.
Nature communications 2012;3():717.
2011: Paquita Nurden; Anne-Cécile Pons; Philippe Rameau; Caroline Rooryck; Guilhem Solé; William Vainchenker; Ibtissam Youlyouz-Marfak; Alexandre Kauskot; Didier Lacombe; Jean-Marie Daniel Lamazière; Alan Nurden; Frédéric Adam; Benoît Arveiler; Eliane Berrou; Marijke Bryckaert; Dorothée Cailley; Isabelle Coupry; Najet Debili; Patricia Fergelot; Cyril Goizet
Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome.
Blood 2011;118(22):5928-37.
2011: Judith Staerk; William Vainchenker; Hélène Antoine-Poirel; Ian Brett; Jean-Philippe Defour; Miki Itaya; Emilie Leroy; Christian Pecquet; Steven O Smith; Stefan N Constantinescu
Orientation-specific signalling by thrombopoietin receptor dimers.
The EMBO journal 2011;30(21):4398-413.
2011: Elodie Pronier; Jean-Luc Ravanat; Audrey Simon; Eric Solary; William Vainchenker; Aparna Vasanthakumar; Carole Almire; Olivier A Bernard; Bruno Carbonne; Nicole Casadevall; Barbara da Costa Reis Monte Mor; Nathalie Droin; Lucy A Godley; Jérôme Larghero; Jean Pierre Le Couédic; Aline Massé; Hayat Mokrani; Frédéric Pendino; Isabelle Plo; François Delhommeau
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
Blood 2011;118(9):2551-5.
2011: William Vainchenker; Stefan N Constantinescu; François Delhommeau; Olivier A Bernard
New mutations and pathogenesis of myeloproliferative neoplasms.
Blood 2011;118(7):1723-35.
2011: Cyril Quivoron; Eric Solary; Marc-Henri Stern; Hervé Tilly; William Vainchenker; Orianne Wagner-Ballon; Bertrand Arnulf; Christian Bastard; Lucile Couronné; Francois Delhommeau; Véronique Della Valle; Philippe Dessen; Marcio Do Cruzeiro; Yannis Duffourd; Michaëla Fontenay; Lucy Godley; Cécile K Lopez; Thomas Mercher; Hélène Merle-Beral; Florence Nguyen Khac; Paule Opolon; Isabelle Plo; Olivier A Bernard
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.
Cancer cell 2011;20(1):25-38.
2011: Claude Capron; Catherine Lacout; Yann Lécluse; Orianne Wagner-Ballon; Anna-Lila Kaushik; Elisabeth Cramer-Bordé; Fred Sablitzky; Dominique Duménil; William Vainchenker
LYL-1 deficiency induces a stress erythropoiesis.
Experimental hematology 2011;39(6):629-42.
2011: Christophe Desterke; Chrystele Bilhou-Nabéra; Bernadette Guerton; Christophe Martinaud; Carole Tonetti; Denis Clay; Paola Guglielmelli; Alessandro Vannucchi; Dominique Bordessoule; Hans Hasselbalch; Brigitte Dupriez; Nassima Benzoubir; Marie-Françoise Bourgeade; Olivier Pierre-Louis; Vladimir Lazar; William Vainchenker; Annelise Bennaceur-Griscelli; Heinz Gisslinger; Stéphane Giraudier; Marie-Caroline Le Bousse-Kerdilès
FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis.
Cancer research 2011;71(8):2901-15.
2011: A-S Gabet; Séverine Coulon; A Fricot; Joël Vandekerckhove; Y Chang; Jean-Antoine Ribeil; L Lordier; Yael Zermati; Vahid Asnafi; Z Belaid; Najet Debili; William Vainchenker; Bruno Varet; Olivier Hermine; Gilles Courtois
Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling.
Cell death and differentiation 2011;18(4):678-89.
2011: Olena Klimchenko; Antonio Di Stefano; Birgit Geoerger; Sofiane Hamidi; Paule Opolon; Thomas Robert; Mélanie Routhier; Jamel El Benna; Anne-Lise Delezoide; Siham Boukour; Bernadette lescure; Eric Solary; William Vainchenker; Françoise Norol
Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.
Blood 2011;117(11):3065-75.
2011: Ayalew Tefferi; William Vainchenker
Myeloproliferative neoplasms: molecular pathophysiology, essential clinical understanding, and treatment strategies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(5):573-82.
2011: Solène Evrard; Olivier Bluteau; Micheline Tulliez; Philippe Rameau; Patrick GONIN; Eva Zetterberg; Jan Palmblad; Arnaud Bonnefoy; Jean-Luc Villeval; William Vainchenker; Stéphane Giraudier; Orianne Wagner-Ballon
Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosis.
Blood 2011;117(1):246-9.
2010: Sonia Poirault-Chassac; Emmanuelle Six; Cyril Catelain; Mélanie Lavergne; Jean-Luc Villeval; William Vainchenker; Evelyne Lauret
Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation.
Blood 2010;116(25):5670-8.
2010: Christine Ragu; Gaelle Elain; Elena Mylonas; Chris Ottolenghi; Nicolas Cagnard; Dominique Daegelen; Emmanuelle Passegué; William Vainchenker; Olivier A Bernard; Virginie Penard-Lacronique
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood 2010;116(22):4464-73.
2010: Larissa Lordier; Yunhua Chang; Abdelali Jalil; Frédéric Aurade; Loïc Garçon; Yann Lécluse; Frédéric Larbret; Toshiyuki Kawashima; Toshio Kitamura; Jérôme Larghero; Najet Debili; William Vainchenker
Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process.
Blood 2010;116(13):2345-55.
2010: Claude Capron; Catherine Lacout; Yann Lécluse; Valérie Jalbert; Hédia Chagraoui; Sabine Charrier; Anne Galy; Annelise Bennaceur-Griscelli; Elisabeth Cramer-Bordé; William Vainchenker
A major role of TGF-beta1 in the homing capacities of murine hematopoietic stem cell/progenitors.
Blood 2010;116(8):1244-53.
2010: Olivier Nibourel; Olivier Kosmider; Meyling Cheok; Nicolas Boissel; Aline Renneville; Noël Philippe; Hervé Dombret; François Dreyfus; Bruno Quesnel; Sandrine Geffroy; Samuel Quentin; Catherine Roche-Lestienne; Jean-Michel Cayuela; Christophe Roumier; Pierre Fenaux; William Vainchenker; Olivier A Bernard; Jean Soulier; Michaëla Fontenay; Claude Preudhomme
Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission.
Blood 2010;116(7):1132-5.
2010: Caroline Marty; Catherine Lacout; Antoine Martin; Salma Hasan; Sylvie Jacquot; Marie-Christine Birling; William Vainchenker; Jean-Luc Villeval
Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.
Blood 2010;116(5):783-7.
2010: Michael Girardot; Christian Pecquet; Siham Boukour; Laurent Knoops; Augustin Ferrant; William Vainchenker; Stéphane Giraudier; Stefan N Constantinescu
miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets.
Blood 2010;116(3):437-45.
2010: C Ragu; S Boukour; G Elain; O Wagner-Ballon; H Raslova; Najet Debili; E N Olson; D Daegelen; William Vainchenker; Olivier A Bernard; Virginie Penard-Lacronique
The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development.
Leukemia 2010;24(6):1227-30.
2010: Philip A Beer; François Delhommeau; Jean-Pierre LeCouédic; Mark A Dawson; Edwin Chen; David Bareford; Rajko Kusec; Mary Frances McMullin; Claire N Harrison; Alessandro M Vannucchi; William Vainchenker; Anthony R Green
Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm.
Blood 2010;115(14):2891-900.
2010: Christian Pecquet; Judith Staerk; Ronan Chaligné; Valerie Goss; Kimberly A Lee; Xiaowu Zhang; John Rush; Joanne Van Hees; Hélène A Poirel; Jean-Marie Scheiff; William Vainchenker; Stéphane Giraudier; Roberto D Polakiewicz; Stefan N Constantinescu
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.
Blood 2010;115(5):1037-48.
2010: Jinyun Yuan; Asokan Devarajan; Rosita Moya-Castro; Menghua Zhang; Stella Evans; Noam Bourquard; Peter Dias; Catherine Lacout; William Vainchenker; Srinivasa T Reddy; Prasad S Koka
Putative innate immunity of antiatherogenic paraoxanase-2 via STAT5 signal transduction in HIV-1 infection of hematopoietic TF-1 cells and in SCID-hu mice.
Journal of stem cells 2010;5(1):43-8.
2010: Rodolphe Besancenot; Ronan Chaligné; Carole Tonetti; Florence Pasquier; Caroline Marty; Yann Lécluse; William Vainchenker; Stefan N Constantinescu; Stéphane Giraudier
A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation.
PLoS biology 2010;8(9):.
2010: Dominique Goossens; Marie-Marcelle Trinh-Trang-Tan; Martine Debbia; Pierre Ripoche; Camilo Vilela-Lamego; Fawzia Louache; William Vainchenker; Yves Colin; Jean-Pierre Cartron
Generation and characterisation of Rhd and Rhag null mice.
British journal of haematology 2010;148(1):161-72.
2009: Olivier Kosmider; Véronique Gelsi-Boyer; Marion Ciudad; Cindy Racoeur; Valérie Jooste; Norbert Vey; Bruno Quesnel; Pierre Fenaux; Jean-Noël Bastie; Odile Beyne-Rauzy; Aspasia Stamatoulas; François Dreyfus; Norbert Ifrah; Stéphane de Botton; William Vainchenker; Olivier A Bernard; Daniel Birnbaum; Michaëla Fontenay; Eric Solary
TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia.
Haematologica 2009;94(12):1676-81.
2009: Laure Gilles; Dominique Bluteau; Siham Boukour; Yunhua Chang; Yanyan Zhang; Thomas Robert; Philippe Dessen; Najet Debili; Olivier A Bernard; William Vainchenker; Hana Raslova
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9.
Blood 2009;114(19):4221-32.
2009: Olivier Kosmider; Véronique Gelsi-Boyer; Meyling Cheok; Sophie Grabar; Véronique Della Valle; Françoise Picard; Franck Viguié; Bruno Quesnel; Odile Beyne-Rauzy; Eric Solary; Norbert Vey; Mathilde Hunault-Berger; Pierre Fenaux; Véronique Mansat-De Mas; Eric Delabesse; Philippe Guardiola; Catherine Lacombe; William Vainchenker; Claude Preudhomme; François Dreyfus; Olivier A Bernard; Daniel Birnbaum; Michaëla Fontenay
TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).
Blood 2009;114(15):3285-91.
2009: Olivier A Bernard; François Delhommeau; Michaela Fontenay; William Vainchenker
[Mutations in TET2 in myeloid cancers].
Médecine sciences : M/S 2009;25(10):785-8.
2009: Abire Jedidi; Caroline Marty; Charleen Oligo; Laurence Jeanson-Leh; Jean-Antoine Ribeil; Nicole Casadevall; Anne Galy; William Vainchenker; Jean-Luc Villeval
Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines.
Blood 2009;114(9):1842-51.
2009: Cécile Saint-Martin; Gwendoline Leroy; François Delhommeau; Gérard Panelatti; Sabrina Dupont; Chloé James; Isabelle Plo; Dominique Bordessoule; Christine Chomienne; André Delannoy; Alain Devidas; Martine Gardembas-Pain; Françoise Isnard; Yves Plumelle; Olivier Bernard; William Vainchenker; Albert Najman; Christine Bellanné-Chantelot
Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms.
Blood 2009;114(8):1628-32.
2009: Olena Klimchenko; Marcella Mori; Antonio Distefano; Thierry Langlois; Frédéric Larbret; Yann Lecluse; Olivier FERAUD; William Vainchenker; Françoise Norol; Najet Debili
A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.
Blood 2009;114(8):1506-17.
2009: Isabelle Plo; Yanyan Zhang; Jean Pierre Le Couédic; Mayuka Nakatake; Jean-Michel Boulet; Miki Itaya; Steven O Smith; Najet Debili; Stefan N Constantinescu; William Vainchenker; Fawzia Louache; Stéphane de Botton
An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.
The Journal of experimental medicine 2009;206(8):1701-7.
2009: Elisabeth Schaffner-Reckinger; Alexandre Salsmann; Najet Debili; J Bellis; J De Mey; William Vainchenker; Willem H Ouwehand; NELLY KIEFFER
Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells.
Journal of thrombosis and haemostasis : JTH 2009;7(7):1207-17.
2009: François Delhommeau; Sabrina Dupont; Véronique Della Valle; Chloé James; Severine Trannoy; Aline Massé; Olivier Kosmider; Jean-Pierre Le Couedic; Fabienne Robert; Antonio Alberdi; Yann Lécluse; Isabelle Plo; François J Dreyfus; Christophe Marzac; Nicole Casadevall; Catherine Lacombe; Serge P Romana; Philippe Dessen; Jean Soulier; Franck Viguié; Michaela Fontenay; William Vainchenker; Olivier A Bernard
Mutation in TET2 in myeloid cancers.
The New England journal of medicine 2009;360(22):2289-301.
2009: Caroline Marty; Ronan Chaligné; Catherine Lacout; Stefan N Constantinescu; William Vainchenker; Jean-Luc Villeval
Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity.
The Journal of biological chemistry 2009;284(18):11781-91.
2009: Thomas Mercher; Glen D Raffel; Sandra A Moore; Melanie G Cornejo; Dominique Baudry-Bluteau; Nicolas Cagnard; Jonathan L Jesneck; Yana Pikman; Dana Cullen; Ifor Williams; Koichi Akashi; Hirokazu Shigematsu; Jean-Pierre Bourquin; Marco Giovannini; William Vainchenker; Ross Levine; Benjamin H Lee; Olivier A Bernard; D Gary Gilliland
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
The Journal of clinical investigation 2009;119(4):852-64.
2009: Isabelle Plo; William Vainchenker
Molecular and genetic bases of myeloproliferative disorders: questions and perspectives.
Clinical lymphoma & myeloma 2009;9 Suppl 3():S329-39.
2009: Paul Coppo; Isabelle Dusanter-Fourt; William Vainchenker; Ali G Turhan
BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels.
Cellular signalling 2009;21(1):52-60.
2008: Sebastien Malinge; Christine Ragu; Véronique Della Valle; Didier F Pisani; Stefan N Constantinescu; Christelle Perez; Jean-Luc Villeval; Dirk Reinhardt; Judith Landman-Parker; Lucienne Michaux; Nicole Dastugue; André Baruchel; William Vainchenker; Jean-Pierre Bourquin; Virginie Penard-Lacronique; Olivier A Bernard
Activating mutations in human acute megakaryoblastic leukemia.
Blood 2008;112(10):4220-6.
2008: Larissa Lordier; Abdelali JALIL; Fréderic Aurade; Fréderic Larbret; Jerôme Larghero; Najet Debili; William Vainchenker; Yunhua Chang
Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling.
Blood 2008;112(8):3164-74.
2008: Chloé James; Frederic Mazurier; Sabrina Dupont; Ronan Chaligne; Isabelle Lamrissi-Garcia; Micheline Tulliez; Eric Lippert; François-Xavier Mahon; Jean-Max Pasquet; Gabriel Etienne; François Delhommeau; Stephane Giraudier; William Vainchenker; Hubert de Verneuil
The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity.
Blood 2008;112(6):2429-38.
2008: Isabelle Plo; Mayuka Nakatake; Laurent Malivert; Jean-Pierre De Villartay; Stéphane Giraudier; Jean-Luc Villeval; Lisa Wiesmuller; William Vainchenker
JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.
Blood 2008;112(4):1402-12.
2008: William Vainchenker; Alexandra Dusa; Stefan N Constantinescu
JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.
Seminars in cell & developmental biology 2008;19(4):385-93.
2008: Fabrice Bouilloux; Gaëtan Juban; Nathalie Cohet; Dorothée Buet; Boris Guyot; William Vainchenker; Fawzia Louache; François Morlé
EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation.
Blood 2008;112(3):576-84.
2008: Eirini Kouroupi; Katerina Zoi; Nathalie Parquet; Christine Zoi; Jean-Jacques Kiladjian; Vassiliki Grigoraki; William Vainchenker; Franck Lellouche; Christophe Marzac; Marie-Hélène Schlageter; Christine Dosquet; Linda Maree SCOTT; Pierre Fenaux; Dimitris Loukopoulos; Christine Chomienne; Bruno Cassinat
Mutations in exon 12 of JAK2 are mainly found in JAK2 V617F-negative polycythaemia vera patients.
British journal of haematology 2008;142(4):676-9.
2008: Najet Debili; William Vainchenker
[From giant to micro: a platelet story].
Médecine sciences : M/S 2008;24(5):467-9.
2008: Laure Gilles; Romain Guièze; Dominique Bluteau; Véronique Cordette-Lagarde; Catherine Lacout; Rémi Favier; Frédéric Larbret; Najet Debili; William Vainchenker; Hana Raslova
P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.
Blood 2008;111(8):4081-91.
2008: Cedric Ghevaert; Alexandre Salsmann; Nicholas A Watkins; Elisabeth Schaffner-Reckinger; Angela Rankin; Stephen F Garner; Jonathan Stephens; Graham Smith; Najet Debili; William Vainchenker; Philip G de Groot; James A Huntington; Mike Laffan; NELLY KIEFFER; Willem H Ouwehand
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.
Blood 2008;111(7):3407-14.
2008: mehdi lahmar; Cyril Catelain; Sonia Poirault; Marion Dorsch; Jean-Luc Villeval; William Vainchenker; Olivier Albagli; Evelyne Lauret
Distinct effects of the soluble versus membrane-bound forms of the notch ligand delta-4 on human CD34+CD38low cell expansion and differentiation.
Stem cells (Dayton, Ohio) 2008;26(3):621-9.
2008: C Haond; Michel Drouet; S Derdouch; Marie-Laure Bonnet; Françoise Norol; J-F Mayol; William Vainchenker; R LeGrand; Ali G Turhan; Francis Herodin
In vitro and in vivo evaluation of the haematopoietic potential of skeletal muscle in a non-human primate model.
Bone marrow transplantation 2008;41(6):579-84.
2007: Ronan Chaligné; Chloé James; Carole Tonetti; Rodolphe Besancenot; Jean Pierre Le Couédic; Fanny Fava; Fréderic Mazurier; Isabelle Godin; Karim Maloum; Frédéric Larbret; Yann Lécluse; William Vainchenker; Stéphane Giraudier
Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis.
Blood 2007;110(10):3735-43.
2007: Nelly Motté; Patrick Saulnier; Jean-Pierre Le Couedic; Jean-Charles Soria; Suzette Delaloge; Valérie Boige; Patricia Pautier; William Vainchenker; Jean-Michel Bidart; Jean-Luc Villeval
Mutations in JAK2V617F homologous domain of JAK genes are uncommon in solid tumors.
International journal of cancer. Journal international du cancer 2007;121(9):2113-5.
2007: Celine Haond; Françoise Farace; Martine Guillier; Yann Lécluse; Frederic Mazurier; William Vainchenker; Ali G Turhan
Quantitative and qualitative in vitro analysis of the stem cell potential of hematopoietic cells purified from murine skeletal muscle.
Cell research 2007;17(9):783-91.
2007: Sabrina Dupont; Aline Massé; Chloé James; Irène Teyssandier; Yann Lécluse; Frédéric Larbret; Valérie Ugo; Patrick Saulnier; serge koscielny; Jean Pierre Le Couédic; Nicole Casadevall; William Vainchenker; François Delhommeau
The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera.
Blood 2007;110(3):1013-21.
2007: Orianne Wagner-Ballon; Didier F Pisani; Thomas Gastinne; Micheline Tulliez; Ronan Chaligné; Catherine Lacout; Frédéric Auradé; Jean-Luc Villeval; Patrick GONIN; William Vainchenker; Stéphane Giraudier
Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.
Blood 2007;110(1):345-53.
2007: Amos Gaikwad; Srdan Verstovsek; Donghoon Yoon; Ko-Tung Chang; Taghi Manshouri; Roberto H Nussenzveig; Jorge Cortes; William Vainchenker; Josef T Prchal
Imatinib effect on growth and signal transduction in polycythemia vera.
Experimental hematology 2007;35(6):931-8.
2007: Michelle B Hookham; Joanne Elliott; Yvonne Suessmuth; Judith Staerk; Alister Ward; William Vainchenker; Melanie J Percy; Mary Frances McMullin; Stefan N Constantinescu; James A Johnston
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3.
Blood 2007;109(11):4924-9.
2007: Yunhua Chang; Frédéric Auradé; Frédéric Larbret; Yanyan Zhang; Jean-Pierre Le Couedic; Laurence Momeux; Jérôme Larghero; Jacques Bertoglio; Fawzia Louache; Elisabeth M Cramer; William Vainchenker; Najet Debili
Proplatelet formation is regulated by the Rho/ROCK pathway.
Blood 2007;109(10):4229-36.
2007: Eva Zetterberg; Alessandro M Vannucchi; Anna Rita Migliaccio; William Vainchenker; Micheline Tulliez; Renée Dickie; Hans Carl Hasselbalch; Rick Rogers; Jan Palmblad
Pericyte coverage of abnormal blood vessels in myelofibrotic bone marrows.
Haematologica 2007;92(5):597-604.
2007: Dorothée Buet; Hana Raslova; Jean-François Geay; Peggy Jarrier; Vladimir Lazar; Ali G Turhan; F Morlé; William Vainchenker; Fawzia Louache
p210(BCR-ABL) reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription.
Leukemia 2007;21(5):917-25.
2007: Hana Raslova; Audrey Kauffmann; Dalila Sekkaï; Hugues Ripoche; Frédéric Larbret; Thomas Robert; Diana Tronik Le Roux; Guido Kroemer; Najet Debili; Philippe Dessen; Vladimir Lazar; William Vainchenker
Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach.
Blood 2007;109(8):3225-34.
2007: Sebastien Malinge; Raouf Ben-Abdelali; Catherine Settegrana; Isabelle Radford-Weiss; Marianne Debre; Kheira Beldjord; Elizabeth Macintyre; Jean-Luc Villeval; William Vainchenker; Roland Berger; Olivier A Bernard; Eric Delabesse; Virginie Penard-Lacronique
Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia.
Blood 2007;109(5):2202-4.
2007: Judith Staerk; Anders Kallin; Yohan Royer; C C Diaconu; A Dusa; Jean-Baptiste Demoulin; William Vainchenker; Stefan N Constantinescu
JAK2, the JAK2 V617F mutant and cytokine receptors.
Pathologie-biologie 2007;55(2):88-91.
2007: Jean-Jacques Kiladjian; Nicole Casadevall; William Vainchenker; Pierre Fenaux
The first international meeting on V617F JAK2 mutation and its relevance in Philadelphia-negative myeloproliferative disorders.
Pathologie-biologie 2007;55(2):85-7.
2007: william raoul; Orianne Wagner-Ballon; Guitanouch Saber; Anne Hulin; Elisabeth Marcos; Stéphane Giraudier; William Vainchenker; Serge Adnot; Saadia Eddahibi; Bernard Maitre
Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.
Respiratory research 2007;8():8.
2007: Thomas Gastinne; Frédéric Vigant; Cecile Lavenu-Bombled; Orianne Wagner-Ballon; Micheline Tulliez; Hédia Chagraoui; Jean-Luc Villeval; Catherine Lacout; Michel Perricaudet; William Vainchenker; Karim Benihoud; Stéphane Giraudier
Adenoviral-mediated TGF-beta1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development.
Experimental hematology 2007;35(1):64-74.
2007: Yanyan Zhang; Monika Wittner; Hakim Bouamar; Peggy Jarrier; William Vainchenker; Fawzia Louache
Identification of CXCR4 as a new nitric oxide-regulated gene in human CD34+ cells.
Stem cells (Dayton, Ohio) 2007;25(1):211-9.
2007: François Delhommeau; Sabrina Dupont; Carole Tonetti; Aline Massé; Isabelle Godin; Jean-Pierre Le Couedic; Najet Debili; Patrick Saulnier; Nicole Casadevall; William Vainchenker; Stéphane Giraudier
Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.
Blood 2007;109(1):71-7.
2006: François Delhommeau; Didier F Pisani; Chloé James; Nicole Casadevall; Stefan N Constantinescu; William Vainchenker
Oncogenic mechanisms in myeloproliferative disorders.
Cellular and molecular life sciences : CMLS 2006;63(24):2939-53.
2006: M Carmen Martínez; Frédéric Larbret; Fatiha Zobairi; Josée Coulombe; Najet Debili; William Vainchenker; Martial Ruat; Jean-Marie Freyssinet
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.
Blood 2006;108(9):3012-20.
2006: Paquita Nurden; Najet Debili; William Vainchenker; Regis BOBE; Raymonde Bredoux; Elisabeth Corvazier; Robert Combrie; Edith Fressinaud; Dominique Meyer; Alan T Nurden; Jocelyne Enouf
Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia.
Blood 2006;108(8):2587-95.
2006: Jean-Jacques Kiladjian; Bruno Cassinat; Pascal Turlure; Nathalie Cambier; Murielle Roussel; Sylvia Bellucci; Marie-Laurence Menot; Gerald Massonnet; Jean-Luc Dutel; Kamel Ghomari; Philippe Rousselot; Marie-Jose Grange; Yasmina Chait; William Vainchenker; Nathalie Parquet; Lina Abdelkader-Aljassem; Jean-François Bernard; Jean-Didier Rain; Sylvie Chevret; Christine Chomienne; Pierre Fenaux
High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a.
Blood 2006;108(6):2037-40.
2006: Loïc Garçon; Christine Rivat; Chloé James; Catherine Lacout; Valérie Camara-Clayette; Valérie Ugo; Yann Lecluse; Annelise Bennaceur-Griscelli; William Vainchenker
Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells.
Blood 2006;108(5):1551-4.
2006: Catherine Lacout; Didier F Pisani; Micheline Tulliez; Françoise Moreau Gachelin; William Vainchenker; Jean-Luc Villeval
JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.
Blood 2006;108(5):1652-60.
2006: Valérie Camara-Clayette; Françoise Le Pesteur; William Vainchenker; Françoise Sainteny
Quantitative Oct4 overproduction in mouse embryonic stem cells results in prolonged mesoderm commitment during hematopoietic differentiation in vitro.
Stem cells (Dayton, Ohio) 2006;24(8):1937-45.
2006: Paul Coppo; Stéphane Flamant; Véronique De Mas; Peggy Jarrier; Martine Guillier; Marie-Laure Bonnet; Catherine Lacout; françois guilhot; William Vainchenker; Ali G Turhan
BCR-ABL activates STAT3 via JAK and MEK pathways in human cells.
British journal of haematology 2006;134(2):171-9.
2006: Christine Bellanné-Chantelot; Isabelle Chaumarel; Myriam Labopin; Florence Bellanger; Véronique Barbu; Claudia De Toma; François Delhommeau; Nicole Casadevall; William Vainchenker; Gilles Thomas; Albert Najman
Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders.
Blood 2006;108(1):346-52.
2006: Siham Sabri; Adlen Foudi; Siham Boukour; Brigitte Franc; Sabine Charrier; Martine Jandrot-Perrus; Richard W Farndale; Abdelali JALIL; Mike P Blundell; Elisabeth M Cramer; Fawzia Louache; Najet Debili; Adrian J Thrasher; William Vainchenker
Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment.
Blood 2006;108(1):134-40.
2006: Claude Capron; Yann Lécluse; Anna Lila Kaushik; Adlen Foudi; Catherine Lacout; Dalila Sekkai; Isabelle Godin; Olivier Albagli; Isabelle Poullion; Fedor Svinartchouk; Elisabeth Schanze; William Vainchenker; Fred Sablitzky; Annelise Bennaceur-Griscelli; Dominique Duménil
The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation.
Blood 2006;107(12):4678-86.
2006: Maria Castedo; Arnaud Coquelle; Sonia Vivet; Ilio Vitale; Audrey Kauffmann; Philippe Dessen; Marie O Pequignot; Noelia Casares; Alexander Valent; Shahul Mouhamad; Elise Schmitt; Nazanine Modjtahedi; William Vainchenker; Laurence Zitvogel; Vladimir Lazar; Carmen Garrido; Guido Kroemer
Apoptosis regulation in tetraploid cancer cells.
The EMBO journal 2006;25(11):2584-95.
2006: Jean-Luc Villeval; Chloé James; Didier F Pisani; Nicole Casadevall; William Vainchenker
New insights into the pathogenesis of JAK2 V617F-positive myeloproliferative disorders and consequences for the management of patients.
Seminars in thrombosis and hemostasis 2006;32(4 Pt 2):341-51.
2006: Orianne Wagner-Ballon; Hédia Chagraoui; Eric Prina; Micheline Tulliez; Geneviève Milon; Hana Raslova; Jean-Luc Villeval; William Vainchenker; Stéphane Giraudier
Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6425-33.
2006: Aurelie Olivier; Laurence Jeanson-Leh; Gerben Bouma; Daniel Compagno; Johanna Blondeau; Khalil Seye; Sabine Charrier; Siobhan Burns; Adrian J Thrasher; Olivier Danos; William Vainchenker; Anne Galy
A partial down-regulation of WASP is sufficient to inhibit podosome formation in dendritic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(4):729-37.
2006: Adlen Foudi; Peggy Jarrier; Yanyan Zhang; Monika Wittner; Jean-François Geay; Yann Lecluse; Takashi Nagasawa; William Vainchenker; Fawzia Louache
Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice.
Blood 2006;107(6):2243-51.
2006: Hana Raslova; Véronique Baccini; Lamya Loussaief; Béatrice Comba; Jérôme Larghero; Najet Debili; William Vainchenker
Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.
Blood 2006;107(6):2303-10.
2006: Judith Staerk; Catherine Lacout; Takeshi Sato; Steven O Smith; William Vainchenker; Stefan N Constantinescu
An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.
Blood 2006;107(5):1864-71.
2006: Chloé James; François Delhommeau; Christophe Marzac; Irène Teyssandier; J-P Le Couédic; Stéphane Giraudier; L Roy; Patrick Saulnier; ludovic lacroix; Sébastien Maury; Micheline Tulliez; William Vainchenker; Valérie Ugo; Nicole Casadevall
Detection of JAK2 V617F as a first intention diagnostic test for erythrocytosis.
Leukemia 2006;20(2):350-3.
2006: Hédia Chagraoui; Françoise Wendling; William Vainchenker
Pathogenesis of myelofibrosis with myeloid metaplasia: Insight from mouse models.
Best practice & research. Clinical haematology 2006;19(3):399-412.
2005: Judith Staerk; Anders Kallin; Jean-Baptiste Demoulin; William Vainchenker; Stefan N Constantinescu
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
The Journal of biological chemistry 2005;280(51):41893-9.
2005: Olivier Kosmider; Nicole Denis; Catherine Lacout; William Vainchenker; Patrice Dubreuil; Françoise Moreau-Gachelin
Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.
Cancer cell 2005;8(6):467-78.
2005: Chloé James; Valérie Ugo; Nicole Casadevall; Stefan N Constantinescu; William Vainchenker
A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects.
Trends in molecular medicine 2005;11(12):546-54.
2005: Dalila Sekkaï; Gaëtan Gruel; Magali Herry; Virginie Moucadel; Stefan N Constantinescu; Olivier Albagli; Diana Tronik-Le Roux; William Vainchenker; Annelise Bennaceur-Griscelli
Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells.
Stem cells (Dayton, Ohio) 2005;23(10):1634-42.
2005: Magali Berthebaud; Christel Rivière; Peggy Jarrier; Adlen Foudi; Yanyan Zhang; Daniel Compagno; Anne Galy; William Vainchenker; Fawzia Louache
RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes.
Blood 2005;106(9):2962-8.
2005: Zhizhuang Joe Zhao; William Vainchenker; Sanford B Krantz; Nicole Casadevall; Stefan N Constantinescu
Role of tyrosine kinases and phosphatases in polycythemia vera.
Seminars in hematology 2005;42(4):221-9.
2005: Erwan Le Scolan; Dimitri Pchejetski; Yoshiko Banno; Nicole Denis; Patrick Mayeux; William Vainchenker; Thierry Levade; Françoise Moreau-Gachelin
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression.
Blood 2005;106(5):1808-16.
2005: Stéphane Flamant; Thierry Kortulewski; Aymeric DUGRAY; Marie-Laure Bonnet; Martine Guillier; françois guilhot; Jean-Henri Bourhis; William Vainchenker; Diana Tronik-Le Roux; Ali G Turhan
Osteopontin is upregulated by BCR-ABL.
Biochemical and biophysical research communications 2005;333(4):1378-84.
2005: Alexis Proust; Benoît Guillet; Isabelle Pellier; Petronela Rachieru; Cyrille Hoarau; Ségolène Claeyssens; Claude Léonard; Sabine Charrier; William Vainchenker; Gil Tchernia; Jean Delaunay
Recurrent V75M mutation within the Wiskott-Aldrich syndrome protein: description of a homozygous female patient.
European journal of haematology 2005;75(1):54-9.
2005: Valérie Ugo; Chloé James; William Vainchenker
[A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera].
Médecine sciences : M/S 2005;21(6-7):669-70.
2005: Annelise Bennaceur-Griscelli; William Vainchenker
[Hope and limits in cell therapies].
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 2005;12(2):73-6.
2005: Chloé James; Valérie Ugo; Jean Pierre Le Couédic; Judith Staerk; François Delhommeau; Catherine Lacout; Loïc Garçon; Hana Raslova; Roland Berger; Annelise Bennaceur-Griscelli; Jean-Luc Villeval; Stefan N Constantinescu; Nicole Casadevall; William Vainchenker
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.
Nature 2005;434(7037):1144-8.
2005: Emiko Komura; Carole Tonetti; Virginie Penard-Lacronique; Hédia Chagraoui; Catherine Lacout; Jean Pierre Lecouédic; Philippe Rameau; Najet Debili; William Vainchenker; Stéphane Giraudier
Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression.
Cancer research 2005;65(8):3281-9.
2005: Jean-François Geay; Dorothée Buet; Yanyan Zhang; Adlen Foudi; Peggy Jarrier; Magali Berthebaud; Ali G Turhan; William Vainchenker; Fawzia Louache
p210BCR-ABL inhibits SDF-1 chemotactic response via alteration of CXCR4 signaling and down-regulation of CXCR4 expression.
Cancer research 2005;65(7):2676-83.
2005: Jonathan S Dando; Manuela Tavian; Cyril Catelain; Sonia Poirault; Annelise Bennaceur-Griscelli; Françoise Sainteny; William Vainchenker; Bruno Péault; Evelyne Lauret
Notch/Delta4 interaction in human embryonic liver CD34+ CD38- cells: positive influence on BFU-E production and LTC-IC potential maintenance.
Stem cells (Dayton, Ohio) 2005;23(4):550-60.
2005: Sabine Charrier; Daniel Stockholm; K Seye; Paule Opolon; Mathieu Taveau; David-Alexandre Gross; S Bucher-Laurent; Christophe Delenda; William Vainchenker; Olivier Danos; Anne Galy
A lentiviral vector encoding the human Wiskott-Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice.
Gene therapy 2005;12(7):597-606.
2005: Loïc Garçon; Catherine Lacout; Fedor Svinartchouk; Jean Pierre Le Couédic; Jean-Luc Villeval; William Vainchenker; Dominique Duménil
Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells.
Blood 2005;105(4):1448-55.
2005: William Vainchenker; Stefan N Constantinescu
A unique activating mutation in JAK2 (V617F) is at the origin of polycythemia vera and allows a new classification of myeloproliferative diseases.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005;():195-200.
2004: Siobhan Burns; Giles O Cory; William Vainchenker; Adrian J Thrasher
Mechanisms of WASp-mediated hematologic and immunologic disease.
Blood 2004;104(12):3454-62.
2004: Siham Sabri; Martine Jandrot-Perrus; Jacques Bertoglio; Richard W Farndale; Véronique Mansat-De Mas; Najet Debili; William Vainchenker
Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes.
Blood 2004;104(10):3117-25.
2004: Christophe Borg; Abdelali JALIL; Diego Laderach; Kouji Maruyama; Hiro Wakasugi; Sabine Charrier; Bernhard Ryffel; Alessandra Cambi; Carl G Figdor; William Vainchenker; Anne Galy; Anne Caignard; Laurence Zitvogel
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
Blood 2004;104(10):3267-75.
2004: Hana Raslova; Rémi Favier; Olivier Albagli; William Vainchenker
[Fli1 haploinsufficiency underlies Paris-Trousseau thrombopenia].
Médecine sciences : M/S 2004;20(11):962-4.
2004: Jean-Michel Paulus; Najet Debili; Frédéric Larbret; Jack Levin; William Vainchenker
Thrombopoietin responsiveness reflects the number of doublings undergone by megakaryocyte progenitors.
Blood 2004;104(8):2291-8.
2004: Sabine Charrier; Annie Michaud; Sabrina Badaoui; Sébastien Giroux; Eric Ezan; Françoise Sainteny; Pierre Corvol; William Vainchenker
Inhibition of angiotensin I-converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells.
Blood 2004;104(4):978-85.
2004: Hana Raslova; Emiko Komura; Jean Pierre Le Couédic; Frédéric Larbret; Najet Debili; Jean Feunteun; Olivier Danos; Olivier Albagli; William Vainchenker; Rémi Favier
FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia.
The Journal of clinical investigation 2004;114(1):77-84.
2004: Charles Decraene; Loïc Garçon; Catherine Lacout; Siham Sabri; Charles Auffray; William Vainchenker; Dominique Duménil; Geneviève Piétu; F Svinartchuk
Zyxin is up-regulated during megakaryocytic differentiation of human UT-7/c-mpl cells.
Biochemical and biophysical research communications 2004;318(2):439-43.
2004: Maria Castedo; Jean-Luc PERFETTINI; Thomas Roumier; Alexander Valent; Hana Raslova; Kenichi Yakushijin; David A Horne; Jean Feunteun; Gilbert Lenoir; René Medema; William Vainchenker; Guido Kroemer
Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.
Oncogene 2004;23(25):4362-70.
2004: Evelyne Lauret; C Catelain; Monique Titeux; S Poirault; J S Dando; M Dorsch; Jean-Luc Villeval; A Groseil; William Vainchenker; Françoise Sainteny; Annelise Bennaceur-Griscelli
Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential.
Leukemia 2004;18(4):788-97.
2004: Gaël A Millot; William Vainchenker; Dominique Duménil; Fédor Svinarchuk
Differential signalling of NH2-terminal flag-labelled thrombopoietin receptor activated by TPO or anti-FLAG antibodies.
Cellular signalling 2004;16(3):355-63.
2004: Valérie Ugo; Christophe Marzac; Irène Teyssandier; Frédéric Larbret; Yann Lécluse; Najet Debili; William Vainchenker; Nicole Casadevall
Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera.
Experimental hematology 2004;32(2):179-87.
2004: Françoise Farace; prestoz laetitia; Sabrina Badaoui; Martine Guillier; Celine Haond; Paule Opolon; Jean-Leon Thomas; Bernard Zalc; William Vainchenker; Ali G Turhan
Evaluation of hematopoietic potential generated by transplantation of muscle-derived stem cells in mice.
Stem cells and development 2004;13(1):83-92.
2004: Yanyan Zhang; Adlen Foudi; Jean-François Geay; Magali Berthebaud; Dorothée Buet; Peggy Jarrier; Abdelali JALIL; William Vainchenker; Fawzia Louache
Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells.
Stem cells (Dayton, Ohio) 2004;22(6):1015-29.
2004: Najet Debili; Fawzia Louache; William Vainchenker
Isolation and culture of megakaryocyte precursors.
Methods in molecular biology (Clifton, N.J.) 2004;272():293-308.
2003: Hédia Chagraoui; Siham Sabri; Claude Capron; Jean-Luc Villeval; William Vainchenker; Françoise Wendling
Expression of osteoprotegerin mRNA and protein in murine megakaryocytes.
Experimental hematology 2003;31(11):1081-8.
2003: Diego Laderach; Daniel Compagno; Olivier Danos; William Vainchenker; Anne Galy
RNA interference shows critical requirement for NF-kappa B p50 in the production of IL-12 by human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1750-7.
2003: Catherine Lacout; Elie Haddad; Siham Sabri; Fedor Svinarchouk; Loïc Garçon; Claude Capron; Adlen Foudi; Rym Mzali; Scott B Snapper; Fawzia Louache; William Vainchenker; Dominique Duménil
A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome.
Blood 2003;102(4):1282-9.
2003: Emiko Komura; Hédia Chagraoui; Véronique Mansat-De Mas; Benoit Blanchet; Paulo de Sepulveda; Frédéric Larbret; Jérôme Larghero; Micheline Tulliez; Najet Debili; William Vainchenker; Stéphane Giraudier
Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: possible relationship with FKBP51 overexpression.
Experimental hematology 2003;31(7):622-30.
2003: Paul Coppo; Isabelle Dusanter-Fourt; Gaël A Millot; Maria Nogueira; Aymeric DUGRAY; Marie-Laure Bonnet; Maria Teresa Mitjavila-Garcia; Dominique Le Pesteur; françois guilhot; William Vainchenker; Françoise Sainteny; Ali G Turhan
Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.
Oncogene 2003;22(26):4102-10.
2003: Bassam Abdulkarim; Siham Sabri; Diana Zelenika; Eric Deutsch; Valerie Frascogna; Jerzy Klijanienko; William Vainchenker; Irene Joab; Jean Bourhis
Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies.
Oncogene 2003;22(15):2260-71.
2003: Hédia Chagraoui; Micheline Tulliez; Tarek Smayra; Emiko Komura; Stéphane Giraudier; Theodore Yun; Nathalie Lassau; William Vainchenker; Françoise Wendling
Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO.
Blood 2003;101(8):2983-9.
2003: Hana Raslova; Lydia Roy; Claire VOURC'H; Jean-Pierre Le Couedic; Olivier Brison; Didier Metivier; Jean Feunteun; Guido Kroemer; Najet Debili; William Vainchenker
Megakaryocyte polyploidization is associated with a functional gene amplification.
Blood 2003;101(2):541-4.
2002: Olivier Sordet; Cédric Rébé; Stéphanie Plenchette; Yael Zermati; Olivier Hermine; William Vainchenker; Carmen Garrido; Eric Solary; Laurence Dubrez-Daloz
Specific involvement of caspases in the differentiation of monocytes into macrophages.
Blood 2002;100(13):4446-53.
2002: François Delhommeau; Antoine Thierry; Danielle Feneux; Evelyne Lauret; Edwige Leclercq; Marie Hélène Courtier; Françoise Sainteny; William Vainchenker; Annelise Bennaceur-Griscelli
Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant.
Oncogene 2002;21(54):8262-71.
2002: Hédia Chagraoui; Emiko Komura; Micheline Tulliez; Stéphane Giraudier; William Vainchenker; Françoise Wendling
Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice.
Blood 2002;100(10):3495-503.
2002: Stéphane Giraudier; Hédia Chagraoui; Emiko Komura; Stéphane Barnache; Benoit Blanchet; Jean Pierre LeCouedic; David Smith; Frédéric Larbret; Anne-Laure Taksin; Françoise Moreau-Gachelin; Nicole Casadevall; Micheline Tulliez; Anne Hulin; Najet Debili; William Vainchenker
Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors.
Blood 2002;100(8):2932-40.
2002: Stéphane de Botton; Siham Sabri; Eric Daugas; Yael Zermati; Jacques-Emmanuel Guidotti; Olivier Hermine; Guido Kroemer; William Vainchenker; Najet Debili
Platelet formation is the consequence of caspase activation within megakaryocytes.
Blood 2002;100(4):1310-7.
2002: Françoise Norol; Michel Drouet; Françoise Pflumio; Marjorie Léonardi; Frédéric Mourcin; Najet Debili; Agnès Job; William Vainchenker; Mathieu Kuentz; Francis Hérodin
Ex vivo expansion marginally amplifies repopulating cells from baboon peripheral blood mobilized CD34+ cells.
British journal of haematology 2002;117(4):924-34.
2002: Gaël A Millot; William Vainchenker; Dominique Duménil; Fédor Svinarchuk
Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells.
Journal of cell science 2002;115(Pt 11):2329-37.
2002: Bassam Abdulkarim; Siham Sabri; Eric Deutsch; Hédia Chagraoui; Laurence Maggiorella; Jerome Thierry; François Eschwege; William Vainchenker; Salem Chouaïb; Jean Bourhis
Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers.
Oncogene 2002;21(15):2334-46.
2002: Maria Teresa Mitjavila-Garcia; Michel Cailleret; Isabelle Godin; Maria Nogueira; Karine Cohen-Solal; Valérie Schiavon; Yann Lecluse; Françoise Le Pesteur; Anne Hélène Lagrue; William Vainchenker
Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells.
Development (Cambridge, England) 2002;129(8):2003-13.
2002: Marie-Dominique Filippi; Françoise Porteu; Françoise Le Pesteur; Valérie Schiavon; Gaël A Millot; William Vainchenker; Frederic J de Sauvage; Anne Dubart Kupperschmitt; Françoise Sainteny
Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro.
Blood 2002;99(4):1174-82.
2002: Roger A Fleischman; Rémi Letestu; Xiafang Mi; David Stevens; Jeffrey Winters; Najet Debili; William Vainchenker
Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome.
British journal of haematology 2002;116(2):367-75.
2002: Gaël A Millot; Fréderic Feger; Loïc Garçon; William Vainchenker; Dominique Dumenil; Fédor Svinarchuk
MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin-mediated cell growth.
Experimental hematology 2002;30(2):166-75.
2001: V Baccini; Lydia Roy; N Vitrat; Hédia Chagraoui; Siham Sabri; Jean-Pierre Le Couedic; Najet Debili; Françoise Wendling; William Vainchenker
Role of p21(Cip1/Waf1) in cell-cycle exit of endomitotic megakaryocytes.
Blood 2001;98(12):3274-82.
2001: Jean-Michel Paulus; J Levin; Najet Debili; Adelin Albert; William Vainchenker
Genesis of clone size heterogeneity in megakaryocytic and other hemopoietic colonies: the stochastic model revisited.
Experimental hematology 2001;29(11):1256-69.
2001: Hédia Chagraoui; Stéphane Giraudier; William Vainchenker; Françoise Wendling
Adenoviral supply of active transforming growth factor-beta1 (TGF-beta1) did not prevent lethality in transforming growth factor-beta1-knockout embryos.
European cytokine network 2001;12(4):561-7.
2001: Aymeric DUGRAY; Jean-François Geay; Adlen Foudi; Marie-Laure Bonnet; William Vainchenker; F Wendling; Fawzia Louache; Ali G Turhan
Rapid generation of a tetracycline-inducible BCR-ABL defective retrovirus using a single autoregulatory retroviral cassette.
Leukemia 2001;15(10):1658-62.
2001: E L Scolan; Françoise Wendling; Stéphane Barnache; Nicole Denis; Micheline Tulliez; William Vainchenker; Françoise Moreau-Gachelin
Germ-line deletion of p53 reveals a multistage tumor progression in spi-1/PU.1 transgenic proerythroblasts.
Oncogene 2001;20(39):5484-92.
2001: M Ahmed; Isabelle Dusanter-Fourt; Aymeric DUGRAY; L Dubrez; Sophie Novault; Marie-Laure Bonnet; Sylvie Gisselbrecht; B Varet; Eric Solary; William Vainchenker; Ali G Turhan
BCR-ABL fails to inhibit apoptosis in U937 myelomonocytic cells expressing a carboxyl-terminal truncated STAT5.
Leukemia & lymphoma 2001;42(3):445-55.
2001: William Vainchenker
[Hematopoietic stem cells].
Thérapie 2001;56(4):379-81.
2001: A H Lagrue-Lak-Hal; Najet Debili; G Kingbury; Christelle Lecut; Jean-Pierre Le Couedic; Jean-Luc Villeval; Martine Jandrot-Perrus; William Vainchenker
Expression and function of the collagen receptor GPVI during megakaryocyte maturation.
The Journal of biological chemistry 2001;276(18):15316-25.
2001: Lydia Roy; Philippe Coullin; N Vitrat; R Hellio; Najet Debili; J Weinstein; Alain BERNHEIM; William Vainchenker
Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes.
Blood 2001;97(8):2238-47.
2001: Eric Deutsch; Aymeric DUGRAY; Bassam Abdulkarim; Elizabeth Marangoni; Laurence Maggiorella; Sabine Vaganay; Radhia M'kacher; S D Rasy; François Eschwege; William Vainchenker; Ali G Turhan; Jean Bourhis
BCR-ABL down-regulates the DNA repair protein DNA-PKcs.
Blood 2001;97(7):2084-90.
2001: Najet Debili; Catherine Robin; Valérie Schiavon; Rémi Letestu; Françoise Pflumio; Maria Teresa Mitjavila-Garcia; Laure Coulombel; William Vainchenker
Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates.
Blood 2001;97(7):2023-30.
2001: Gaël A Millot; Fédor Svinarchuk; Catherine Lacout; William Vainchenker; Dominique Dumenil
The granulocyte colony-stimulating factor receptor supports erythroid differentiation in the absence of the erythropoietin receptor or Stat5.
British journal of haematology 2001;112(2):449-58.
2001: Annelise Bennaceur-Griscelli; C Pondarré; Valérie Schiavon; William Vainchenker; Laure Coulombel
Stromal cells retard the differentiation of CD34(+)CD38(low/neg) human primitive progenitors exposed to cytokines independent of their mitotic history.
Blood 2001;97(2):435-41.
2001: Elie Haddad; José L Zugaza; Fawzia Louache; Najet Debili; Catherine Crouin; K Schwarz; A Fischer; William Vainchenker; Jacques Bertoglio
The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.
Blood 2001;97(1):33-8.
2000: Aude Sirven; Françoise Pflumio; Véronique Zennou; Monique Titeux; William Vainchenker; Laure Coulombel; Anne Dubart Kupperschmitt; Pierre Charneau
The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells.
Blood 2000;96(13):4103-10.
2000: Marie-Dominique Filippi; Françoise Porteu; Françoise Le Pesteur; Philippe Rameau; Maria Nogueira; Najet Debili; William Vainchenker; Frederic J de Sauvage; A D Kupperschmitt; Françoise Sainteny
Embryonic stem cell differentiation to hematopoietic cells: A model to study the function of various regions of the intracytoplasmic domain of cytokine receptors in vitro.
Experimental hematology 2000;28(12):1363-72.
2000: Maria Nogueira; Maria Teresa Mitjavila-Garcia; Françoise Le Pesteur; Marie-Dominique Filippi; William Vainchenker; Anne Dubart Kupperschmitt; Françoise Sainteny
Regulation of Id gene expression during embryonic stem cell-derived hematopoietic differentiation.
Biochemical and biophysical research communications 2000;276(2):803-12.
2000: Martine Jandrot-Perrus; Samantha J Busfield; AH Lagrue; Ximing Xiong; Najet Debili; TW Chickering; Jean-Pierre Le Couedic; Andrew Goodearl; B Dussault; C Fraser; William Vainchenker; Jean-Luc Villeval
Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.
Blood 2000;96(5):1798-807.
2000: N Vitrat; Rémi Letestu; Aline Massé; Vladimir Lazar; William Vainchenker; Najet Debili
Thromboxane synthase has the same pattern of expression as platelet specific glycoproteins during human megakaryocyte differentiation.
Thrombosis and haemostasis 2000;83(5):759-68.
2000: Bassam Abdulkarim; Siham Sabri; Eric Deutsch; Sabine Vaganay; Elizabeth Marangoni; William Vainchenker; P Bongrand; Pierre Busson; Jean Bourhis
Radiation-induced expression of functional Fas ligand in EBV-positive human nasopharyngeal carcinoma cells.
International journal of cancer. Journal international du cancer 2000;86(2):229-37.
2000: Françoise Norol; Michel Drouet; J Mathieu; Najet Debili; H Jouault; Nancy Grenier; A Laplanche; William Vainchenker; Francis Hérodin
Ex vivo expanded mobilized peripheral blood CD34+ cells accelerate haematological recovery in a baboon model of autologous transplantation.
British journal of haematology 2000;109(1):162-72.
2000: C Issaad; M Ahmed; Sophie Novault; Marie-Laure Bonnet; T Bennardo; B Varet; William Vainchenker; Ali G Turhan
Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7.
Leukemia 2000;14(4):662-70.
2000: Rémi Letestu; N Vitrat; Aline Massé; Jean-Pierre Le Couedic; Vladimir Lazar; Philippe Rameau; Françoise Wendling; J Vuillier; Patrick Boutard; Emmanuel Plouvier; M Plasse; Remi Favier; William Vainchenker; Najet Debili
Existence of a differentiation blockage at the stage of a megakaryocyte precursor in the thrombocytopenia and absent radii (TAR) syndrome.
Blood 2000;95(5):1633-41.
1999: Ali G Turhan; Jean-Henri Bourhis; Marie-Laure Bonnet; Sophie Novault; Chantal Bayle; Annelise Bennaceur; William Vainchenker; José-Luis Pico; Françoise Beaujean
Unfractionated peripheral blood stem cell autografts and CD(34+)-enriched autografts have similar long-term culture initiating capacity in multiple myeloma.
Hematology and cell therapy 1999;41(5):197-204.
1999: Annelise Bennaceur-Griscelli; Cristina Tourino; Brigitte Izac; William Vainchenker; Laure Coulombel
Murine stromal cells counteract the loss of long-term culture-initiating cell potential induced by cytokines in CD34(+)CD38(low/neg) human bone marrow cells.
Blood 1999;94(2):529-38.
1999: Elie Haddad; Elisabeth M Cramer; Christel Rivière; Philippe Rameau; Fawzia Louache; Josette Guichard; D L Nelson; A Fischer; William Vainchenker; Najet Debili
The thrombocytopenia of Wiskott Aldrich syndrome is not related to a defect in proplatelet formation.
Blood 1999;94(2):509-18.
1999: Catherine Robin; Françoise Pflumio; William Vainchenker; Laure Coulombel
Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells.
The Journal of experimental medicine 1999;189(10):1601-10.
1999: Karine Cohen-Solal; N Vitrat; Monique Titeux; William Vainchenker; Françoise Wendling
High-level expression of Mpl in platelets and megakaryocytes is independent of thrombopoietin.
Blood 1999;93(9):2859-66.
1999: Françoise Norol; Michel Drouet; Najet Debili; William Vainchenker; Francis Herodin
[Ex-vivo expansion of hematopoietic stem cells: study in the primate model].
Hematology and cell therapy 1999;41(2):75-7.
1999: Catherine Robin; Annelise Bennaceur-Griscelli; Fawzia Louache; William Vainchenker; Laure Coulombel
Identification of human T-lymphoid progenitor cells in CD34+ CD38low and CD34+ CD38+ subsets of human cord blood and bone marrow cells using NOD-SCID fetal thymus organ cultures.
British journal of haematology 1999;104(4):809-19.
1999: Christel Rivière; Frédéric Subra; Karine Cohen-Solal; V Cordette-Lagarde; Rémi Letestu; Christian Auclair; William Vainchenker; Fawzia Louache
Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis.
Blood 1999;93(5):1511-23.
1999: SA Burstein; A Dubart; Françoise Norol; Najet Debili; Paul Friese; Tamyra Downs; X Yu; P W Kincade; Jean-Luc Villeval; William Vainchenker
Expression of a foreign protein in human megakaryocytes and platelets by retrovirally mediated gene transfer.
Experimental hematology 1999;27(1):110-6.
1999: Anne-Laure Taksin; J P Couedic; Isabelle Dusanter-Fourt; Aline Massé; Stéphane Giraudier; A Katz; Françoise Wendling; William Vainchenker; Nicole Casadevall; Najet Debili
Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L.
Blood 1999;93(1):125-39.
1998: T Byk; Hedi Haddada; William Vainchenker; Fawzia Louache
Lipofectamine and related cationic lipids strongly improve adenoviral infection efficiency of primitive human hematopoietic cells.
Human gene therapy 1998;9(17):2493-502.
1998: William Vainchenker; Najet Debili; Françoise Norol; Françoise Wendling
[Thrombopoietin and megakaryocyte differentiation].
Schweizerische medizinische Wochenschrift 1998;128(42):1575-81.
1998: Ali G Turhan; Eric Solary; William Vainchenker; Isabelle Dusanter-Fourt
Molecular pathophysiology of chronic myelogenous leukemia.
Hematology and cell therapy 1998;40(5):217-21.
1998: Françoise Wendling; William Vainchenker
Thrombopoietin and its receptor.
European cytokine network 1998;9(3):221-31.
1998: F Goncalves; Catherine Lacout; F Féger; Karine Cohen-Solal; Josette Guichard; Elisabeth M Cramer; William Vainchenker; Dominique Duménil
Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7/c-mpl and TF-1/c-mpl cell lines.
Leukemia 1998;12(9):1355-66.
1998: A Marandin; Anne Dubart; Françoise Pflumio; François-Loïc Cosset; V Cordette; S Chapel-Fernandes; Laure Coulombel; William Vainchenker; Fawzia Louache
Retrovirus-mediated gene transfer into human CD34+38low primitive cells capable of reconstituting long-term cultures in vitro and nonobese diabetic-severe combined immunodeficiency mice in vivo.
Human gene therapy 1998;9(10):1497-511.
1998: Stéphane Barnache; Françoise Wendling; C Lacombe; Nicole Denis; Monique Titeux; William Vainchenker; Françoise Moreau-Gachelin
Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation.
Oncogene 1998;16(23):2989-95.
1998: N Vitrat; Karine Cohen-Solal; Claudine Pique; Jean-Pierre Le Couedic; Françoise Norol; Annette K Larsen; A Katz; William Vainchenker; Najet Debili
Endomitosis of human megakaryocytes are due to abortive mitosis.
Blood 1998;91(10):3711-23.
1998: Mohamed Amine Abina; Micheline Tulliez; Marie-Thérèse Duffour; Najet Debili; Catherine Lacout; Jean-Luc Villeval; Françoise Wendling; William Vainchenker; Hedi Haddada
Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4481-9.
1998: Mohamed Amine Abina; Micheline Tulliez; Catherine Lacout; Najet Debili; Jean-Luc Villeval; Françoise Pflumio; Françoise Wendling; William Vainchenker; Hedi Haddada
Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression.
Gene therapy 1998;5(4):497-506.
1998: M T Mitjavila; Marie-Dominique Filippi; Karine Cohen-Solal; Françoise Le Pesteur; William Vainchenker; Françoise Sainteny
The Mpl-ligand is involved in the growth-promoting activity of the murine stromal cell line MS-5 on ES cell-derived hematopoiesis.
Experimental hematology 1998;26(2):124-34.
1998: Françoise Norol; N Vitrat; Elisabeth M Cramer; Josette Guichard; SA Burstein; William Vainchenker; Najet Debili
Effects of cytokines on platelet production from blood and marrow CD34+ cells.
Blood 1998;91(3):830-43.
1998: A L Taskin; Karine Cohen-Solal; Jean-Pierre Le Couedic; Mohamed Amine Abina; Jean-Luc Villeval; Najet Debili; Nicole Casadevall; William Vainchenker; Françoise Wendling
Myelofibrosis: experimental models and human studies.
Stem cells (Dayton, Ohio) 1998;16 Suppl 2():155-64.
1998: N Vitrat; Karine Cohen-Solal; Françoise Norol; Josette Guichard; Elisabeth M Cramer; William Vainchenker; Françoise Wendling; Najet Debili
Compared effects of Mpl ligand and other cytokines on human MK differentiation.
Stem cells (Dayton, Ohio) 1998;16 Suppl 2():37-51.
1998: Françoise Wendling; Karine Cohen-Solal; Jean-Luc Villeval; Najet Debili; William Vainchenker
Mpl ligand or thrombopoietin: biological activities.
Biotherapy (Dordrecht, Netherlands) 1998;10(4):269-77.
1997: Jean-Luc Villeval; Karine Cohen-Solal; Micheline Tulliez; Stéphane Giraudier; Josette Guichard; SA Burstein; Elisabeth M Cramer; William Vainchenker; Françoise Wendling
High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice.
Blood 1997;90(11):4369-83.
1997: Karine Cohen-Solal; Najet Debili; William Vainchenker; Françoise Wendling
Thrombopoietin (Mpl ligand) and the regulation of platelet production.
European cytokine network 1997;8(3):311-4.
1997: Karine Cohen-Solal; Najet Debili; William Vainchenker; Françoise Wendling
Thrombopoietin (Mpl-ligand) and the regulation of platelet production.
Thrombosis and haemostasis 1997;78(1):37-41.
1997: A C Berardi; Eric Meffre; Françoise Pflumio; A Katz; William Vainchenker; Claudine Schiff; Laure Coulombel
Individual CD34+CD38lowCD19-CD10- progenitor cells from human cord blood generate B lymphocytes and granulocytes.
Blood 1997;89(10):3554-64.
1997: F Goncalves; Catherine Lacout; Jean-Luc Villeval; Françoise Wendling; William Vainchenker; Dominique Dumenil
Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation.
Blood 1997;89(10):3544-53.
1997: Elisabeth M Cramer; Françoise Norol; Josette Guichard; J Breton-Gorius; William Vainchenker; Jean-Marc Massé; Najet Debili
Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand.
Blood 1997;89(7):2336-46.
1997: J M Pignon; Stéphane Giraudier; Philippe Duquesnoy; Hélène Jouault; Michèle Imbert; William Vainchenker; Jean-Paul Vernant; Micheline Tulliez
A new c-kit mutation in a case of aggressive mast cell disease.
British journal of haematology 1997;96(2):374-6.
1997: F Féger; Anne Dubart; Catherine Lacout; Isabelle Dusanter-Fourt; Patrick Mayeux; William Vainchenker; Dominique Duménil
Ectopic expression of the erythropoietin receptor in a murine interleukin-6-dependent plasmacytoma cell line (TEPC-2027) confers proliferative responsiveness to erythropoietin.
Blood 1997;89(2):435-45.
1996: A Marandin; A Katz; E Oksenhendler; Micheline Tulliez; F Picard; William Vainchenker; Fawzia Louache
Loss of primitive hematopoietic progenitors in patients with human immunodeficiency virus infection.
Blood 1996;88(12):4568-78.
1996: Françoise Pflumio; B Izac; A Katz; L D Shultz; William Vainchenker; Laure Coulombel
Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells.
Blood 1996;88(10):3731-40.
1996: Karine Cohen-Solal; Jean-Luc Villeval; Monique Titeux; S Lok; William Vainchenker; Françoise Wendling
Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.
Blood 1996;88(7):2578-84.
1996: F Goncalves; Anne Dubart; Catherine Lacout; William Vainchenker; Dominique Duménil
Stromal cells maintain the radioprotective capacity of CFU-S during retroviral infection.
Gene therapy 1996;3(9):761-8.
1996: I Auffray; Sylvie Chevalier; Josy Froger; B Izac; William Vainchenker; Hugues Gascan; Laure Coulombel
Nerve growth factor is involved in the supportive effect by bone marrow--derived stromal cells of the factor-dependent human cell line UT-7.
Blood 1996;88(5):1608-18.
1996: Najet Debili; Laure Coulombel; L Croisille; A Katz; Josette Guichard; J Breton-Gorius; William Vainchenker
Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow.
Blood 1996;88(4):1284-96.
1996: Anne Dubart; Paul-Henri Roméo; William Vainchenker; D Dumenil
Constitutive expression of GATA-1 interferes with the cell-cycle regulation.
Blood 1996;87(9):3711-21.
1996: O Hermine; Anne Dubart; F Porteux; Patrick Mayeux; Monique Titeux; D Dumenil; William Vainchenker
Inhibition of the erythropoietin-induced erythroid differentiation by granulocyte-macrophage colony-stimulating factor in the human UT-7 cell line is not due to a negative regulation of the erythropoietin receptor.
Blood 1996;87(5):1746-53.
1996: Jean-Pierre Le Couedic; M T Mitjavila; Jean-Luc Villeval; F Feger; S Gobert; Patrick Mayeux; Nicole Casadevall; William Vainchenker
Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies.
Blood 1996;87(4):1502-11.
1996: Françoise Wendling; Karine Cohen-Solal; Najet Debili; Jean-Luc Villeval; Monique Titeux; William Vainchenker
[Mpl ligand (thrombopoietin) and platelet regulation].
Annales pharmaceutiques françaises 1996;54(4):177-82.
1996: Catherine Lacout; Anne Dubart; William Vainchenker; Dominique Duménil
Pluripotent stem cells constitutively expressing a normal erythropoietin receptor give rise to normal hematopoiesis in lethally irradiated recipient mice.
Experimental hematology 1996;24(1):18-25.
1995: A Huyhn; M Dommergues; B Izac; L Croisille; A Katz; William Vainchenker; Laure Coulombel
Characterization of hematopoietic progenitors from human yolk sacs and embryos.
Blood 1995;86(12):4474-85.
1995: A Marandin; Bruno Canque; Laure Coulombel; Jean Claude Gluckman; William Vainchenker; Fawzia Louache
In vitro infection of bone marrow-adherent cells by human immunodeficiency virus type 1 (HIV-1) does not alter their ability to support hematopoiesis.
Virology 1995;213(1):245-8.
1995: Najet Debili; Françoise Wendling; A Katz; Josette Guichard; J Breton-Gorius; P Hunt; William Vainchenker
The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors.
Blood 1995;86(7):2516-25.
1995: Françoise Wendling; William Vainchenker
Thrombopoietin and its receptor, the proto-oncogene c-mpl.
Current opinion in hematology 1995;2(5):331-8.
1995: Philippe Bierling; Bertrand Godeau; Patricia Fromont; A Bettaieb; Najet Debili; N el-Kassar; J J Rouby; William Vainchenker; N Duedari
Posttransfusion purpura-like syndrome associated with CD36 (Naka) isoimmunization.
Transfusion 1995;35(9):777-82.
1995: William Vainchenker; Najet Debili; Marc-André Mouthon; Françoise Wendling
Megakaryocytopoiesis: cellular aspects and regulation.
Critical reviews in oncology/hematology 1995;20(1-2):165-92.
1995: William Vainchenker; N Methia; Najet Debili; Monique Titeux; Françoise Wendling
c-mpl, the thrombopoietin receptor.
Thrombosis and haemostasis 1995;74(1):526-8.
1995: L Kobari; Anne Dubart; Françoise Le Pesteur; William Vainchenker; Françoise Sainteny
Hematopoietic-promoting activity of the murine stromal cell line MS-5 is not related to the expression of the major hematopoietic cytokines.
Journal of cellular physiology 1995;163(2):295-304.
1995: Bruno Canque; A Marandin; Michelle Rosenzwajg; Fawzia Louache; William Vainchenker; Jean Claude Gluckman
Susceptibility of human bone marrow stromal cells to human immunodeficiency virus (HIV).
Virology 1995;208(2):779-83.
1995: Nadia Naffakh; A Henri; Jean-Luc Villeval; Philippe Rouyer-Fessard; Philippe Moullier; N Blumenfeld; O Danos; William Vainchenker; Jean Michel Heard; Y Beuzard
Sustained delivery of erythropoietin in mice by genetically modified skin fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3194-8.
1995: J Breton-Gorius; R Favier; Josette Guichard; D Cherif; R Berger; Najet Debili; William Vainchenker; L Douay
A new congenital dysmegakaryopoietic thrombocytopenia (Paris-Trousseau) associated with giant platelet alpha-granules and chromosome 11 deletion at 11q23.
Blood 1995;85(7):1805-14.
1995: N Methia; Najet Debili; Monique Titeux; William Vainchenker; Françoise Wendling
From the v-mpl oncogene to thrombopoietin.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1995;318(4):479-82.
1994: L Croisille; I Auffray; A Katz; B Izac; William Vainchenker; Laure Coulombel
Hydrocortisone differentially affects the ability of murine stromal cells and human marrow-derived adherent cells to promote the differentiation of CD34++/CD38- long-term culture-initiating cells.
Blood 1994;84(12):4116-24.
1994: C Issaad; William Vainchenker
Growth of erythroid colonies in chronic myelogenous leukemia is independent of erythropoietin only in the presence of steel factor.
Blood 1994;84(10):3447-56.
1994: Fawzia Louache; Najet Debili; A Marandin; Laure Coulombel; William Vainchenker
Expression of CD4 by human hematopoietic progenitors.
Blood 1994;84(10):3344-55.
1994: Jean-Luc Villeval; M T Mitjavila; Isabelle Dusanter-Fourt; Françoise Wendling; Patrick Mayeux; William Vainchenker
Autocrine stimulation by erythropoietin (Epo) requires Epo secretion.
Blood 1994;84(8):2649-62.
1994: Fawzia Louache; William Vainchenker
Thrombocytopenia in HIV infection.
Current opinion in hematology 1994;1(5):369-72.
1994: Marc-André Mouthon; M Freund; Monique Titeux; A Katz; Josette Guichard; J Breton-Gorius; William Vainchenker
Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis.
Blood 1994;84(4):1085-97.
1994: Jean-Luc Villeval; Philippe Rouyer-Fessard; N Blumenfeld; A Henri; William Vainchenker; Y Beuzard
Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia.
Blood 1994;84(3):928-33.
1994: V Descamps; N Blumenfeld; Jean-Luc Villeval; William Vainchenker; Michel Perricaudet; Y Beuzard
Erythropoietin gene transfer and expression in adult normal mice: use of an adenovirus vector.
Human gene therapy 1994;5(8):979-85.
1994: Anne Dubart; F Feger; Catherine Lacout; F Goncalves; William Vainchenker; D Dumenil
Murine pluripotent hematopoietic progenitors constitutively expressing a normal erythropoietin receptor proliferate in response to erythropoietin without preferential erythroid cell differentiation.
Molecular and cellular biology 1994;14(7):4834-42.
1994: Françoise Wendling; Eugene Maraskovsky; Najet Debili; C Florindo; Mark Teepe; Monique Titeux; N Methia; J Breton-Gorius; David Cosman; William Vainchenker
cMpl ligand is a humoral regulator of megakaryocytopoiesis.
Nature 1994;369(6481):571-4.
1994: William Vainchenker; Najet Debili; N Methia; Marc-André Mouthon; Françoise Wendling
[Hematopoiesis and its regulation. Comparison between erythropoiesis and megakaryocytopoiesis].
Bulletin de l'Académie nationale de médecine 1994;178(5):753-78; discussion 778-9.
1994: I Auffray; Anne Dubart; B Izac; William Vainchenker; Laure Coulombel
A murine stromal cell line promotes the proliferation of the human factor-dependent leukemic cell line UT-7.
Experimental hematology 1994;22(5):417-24.
1994: Marc-André Mouthon; M T Mitjavila; J Marquet; William Vainchenker; Françoise Wendling
Erroneous results of 3H-thymidine incorporation are related to position of thymidine residues in oligodeoxynucleotides.
Experimental hematology 1994;22(4):384-7.
1994: Philippe Bierling; J M Pignon; Mathieu Kuentz; M T Mitjavila; Patricia Fromont; V Barbu; Michel Goossens; N Duedari; William Vainchenker; Jean-Paul Vernant
Thrombocytopenia after bone marrow transplantation caused by a recipient origin Br(a) allo-antibody: presence of mixed chimerism 3 years after the graft without hematologic relapse.
Blood 1994;83(1):274-9.
1993: Patrick Mayeux; Isabelle Dusanter-Fourt; Odile Muller; P Mauduit; M Sabbah; Brian J Druker; William Vainchenker; S Fischer; Catherine Lacombe; Sylvie Gisselbrecht
Erythropoietin induces the association of phosphatidylinositol 3'-kinase with a tyrosine-phosphorylated protein complex containing the erythropoietin receptor.
European journal of biochemistry / FEBS 1993;216(3):821-8.
1993: N Methia; Fawzia Louache; William Vainchenker; Françoise Wendling
Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis.
Blood 1993;82(5):1395-401.
1993: Najet Debili; Jean-Marc Massé; A Katz; Josette Guichard; J Breton-Gorius; William Vainchenker
Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells.
Blood 1993;82(1):84-95.
1993: N Saadane; Philippe Rouyer-Fessard; Jean-Luc Villeval; N Blumenfeld-Charbit; A Henri; K Leroy-Viard; C Sauvage; E Vicaut; A Maurel; William Vainchenker
[Physiopathologic and therapeutic importance of animal models of hemoglobinopathies].
Nouvelle revue française d'hématologie 1993;35(3):301-2.
1993: Nicole Casadevall; William Vainchenker
[Erythropoiesis and its regulation].
La Revue du praticien 1993;43(11):1335-40.
1993: William Vainchenker
[Regulation of erythropoiesis].
Nouvelle revue française d'hématologie 1993;35(3):309-12.
1993: C Issaad; L Croisille; A Katz; William Vainchenker; Laure Coulombel
A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38- progenitor cells in long-term cultures and semisolid assays.
Blood 1993;81(11):2916-24.
1993: Jean-Paul Fermand; M T Mitjavila; Jean-Pierre Le Couedic; A Tsapis; Roland Berger; Robert Modigliani; M Seligmann; Jean-Claude Brouet; William Vainchenker
Role of granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5 in the eosinophilia associated with T cell lymphoma.
British journal of haematology 1993;83(3):359-64.
1993: Marc-André Mouthon; O Bernard; M T Mitjavila; P H Romeo; William Vainchenker; D Mathieu-Mahul
Expression of tal-1 and GATA-binding proteins during human hematopoiesis.
Blood 1993;81(3):647-55.
1992: O Hermine; Patrick Mayeux; Monique Titeux; M T Mitjavila; Nicole Casadevall; Josette Guichard; N Komatsu; T Suda; Y Miura; William Vainchenker
Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7.
Blood 1992;80(12):3060-9.
1992: Najet Debili; C Issaad; Jean-Marc Massé; Josette Guichard; A Katz; J Breton-Gorius; William Vainchenker
Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation.
Blood 1992;80(12):3022-35.
1992: Fawzia Louache; A Henri; A Bettaieb; E Oksenhendler; G Raguin; Micheline Tulliez; William Vainchenker
Role of human immunodeficiency virus replication in defective in vitro growth of hematopoietic progenitors.
Blood 1992;80(12):2991-9.
1992: Marc-André Mouthon; S Navarro; A Katz; J Breton-Gorius; William Vainchenker
c-jun and c-fos are expressed by human megakaryocytes.
Experimental hematology 1992;20(7):909-15.
1992: A Bettaieb; Patricia Fromont; Fawzia Louache; E Oksenhendler; William Vainchenker; N Duédari; Philippe Bierling
Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura.
Blood 1992;80(1):162-9.
1992: J Breton-Gorius; Philippe Clezardin; Josette Guichard; Najet Debili; Luc Malaval; William Vainchenker; Elisabeth M Cramer; Pierre D Delmas
Localization of platelet osteonectin at the internal face of the alpha-granule membranes in platelets and megakaryocytes.
Blood 1992;79(4):936-41.
1992: Najet Debili; J Breton-Gorius; William Vainchenker
Hematopoietic growth factors and human megakaryocyte differentiation.
Bone marrow transplantation 1992;9 Suppl 1():11-5.
1991: Fawzia Louache; A Bettaieb; A Henri; E Oksenhendler; Jean-Pierre Farcet; Philippe Bierling; M Seligmann; William Vainchenker
Infection of megakaryocytes by human immunodeficiency virus in seropositive patients with immune thrombocytopenic purpura.
Blood 1991;78(7):1697-705.
1991: M T Mitjavila; Jean-Pierre Le Couedic; Nicole Casadevall; S Navarro; Jean-Luc Villeval; Anne Dubart; William Vainchenker
Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitro.
The Journal of clinical investigation 1991;88(3):789-97.
1991: Najet Debili; E Hegyi; S Navarro; A Katz; Marc-André Mouthon; J Breton-Gorius; William Vainchenker
In vitro effects of hematopoietic growth factors on the proliferation, endoreplication, and maturation of human megakaryocytes.
Blood 1991;77(11):2326-38.
1991: E Hegyi; M Nakazawa; Najet Debili; S Navarro; A Katz; J Breton-Gorius; William Vainchenker
Developmental changes in human megakaryocyte ploidy.
Experimental hematology 1991;19(2):87-94.
1991: S Navarro; Najet Debili; Jean-Pierre Le Couedic; B Klein; J Breton-Gorius; J Doly; William Vainchenker
Interleukin-6 and its receptor are expressed by human megakaryocytes: in vitro effects on proliferation and endoreplication.
Blood 1991;77(3):461-71.
1991: Fawzia Louache; Najet Debili; Elisabeth M Cramer; J Breton-Gorius; William Vainchenker
Fibrinogen is not synthesized by human megakaryocytes.
Blood 1991;77(2):311-6.
1991: J Breton-Gorius; M H Vuillet-Gaugler; Laure Coulombel; Josette Guichard; F Teillet; William Vainchenker
Association between leukemic erythroid progenitors and bone marrow macrophages.
Blood cells 1991;17(1):127-42; discussion 142-6.
1990: Najet Debili; NELLY KIEFFER; M Nakazawa; Josette Guichard; Monique Titeux; Elisabeth M Cramer; J Breton-Gorius; William Vainchenker
Expression of platelet glycoprotein Ib by cultured human megakaryocytes: ultrastructural localization and biosynthesis.
Blood 1990;76(2):368-76.
1990: E Hegyi; S Navarro; Najet Debili; Marc-André Mouthon; A Katz; J Breton-Gorius; William Vainchenker
Regulation of human megakaryocytopoiesis: analysis of proliferation, ploidy and maturation in liquid cultures.
International journal of cell cloning 1990;8(4):236-44.
1990: S Navarro; Fawzia Louache; Najet Debili; William Vainchenker; J Doly
Autocrine regulation of terminal differentiation by interleukin-6 in the pluripotent KU812 cell line.
Biochemical and biophysical research communications 1990;169(1):184-91.
1990: Y Levy; Jean-Paul Fermand; S Navarro; C Schmitt; William Vainchenker; M Seligmann; J C Brouet
Interleukin 6 dependence of spontaneous in vitro differentiation of B cells from patients with IgM gammapathy.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3309-13.
1990: P H Romeo; M H Prandini; Virginie Joulin; V Mignotte; Michel Prenant; William Vainchenker; G Marguerie; Georges Uzan
Megakaryocytic and erythrocytic lineages share specific transcription factors.
Nature 1990;344(6265):447-9.
1990: M H Vuillet-Gaugler; J Breton-Gorius; William Vainchenker; Josette Guichard; C Leroy; G Tchernia; Laure Coulombel
Loss of attachment to fibronectin with terminal human erythroid differentiation.
Blood 1990;75(4):865-73.
1990: Elisabeth M Cramer; P Harrison; G F Savidge; B Wilbourn; Najet Debili; William Vainchenker; J Breton-Gorius
Uncoordinated expression of alpha-granule proteins in human megakaryocytes.
Progress in clinical and biological research 1990;356():131-42.
1989: Caroline Le Van Kim; Yves Colin; M T Mitjavila; M Clerget; Anne Dubart; M Nakazawa; William Vainchenker; Jean-Pierre Cartron
Structure of the promoter region and tissue specificity of the human glycophorin C gene.
The Journal of biological chemistry 1989;264(34):20407-14.
1989: P Harrison; B Wilbourn; Najet Debili; William Vainchenker; J Breton-Gorius; A S Lawrie; J M Masse; G F Savidge; Elisabeth M Cramer
Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets.
The Journal of clinical investigation 1989;84(4):1320-4.
1989: Xavier Mariette; M T Mitjavila; J P Moulinie; A Bussel; Jean-Claude Brouet; William Vainchenker; Jean-Paul Fermand
Rifampicin-induced pure red cell aplasia.
The American journal of medicine 1989;87(4):459-60.
1989: NELLY KIEFFER; A Bettaieb; C Legrand; Laure Coulombel; William Vainchenker; L Edelman; J Breton-Gorius
Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor.
The Biochemical journal 1989;262(3):835-42.
1989: Najet Debili; NELLY KIEFFER; M T Mitjavila; Jean-Luc Villeval; Josette Guichard; F Teillet; A Henri; Kenneth J Clemetson; William Vainchenker; J Breton-Gorius
Expression of platelet glycoproteins by erythroid blasts in four cases of trisomy 21.
Leukemia 1989;3(9):669-78.
1989: J F Caubet; M T Mitjavila; Anne Dubart; D Roten; S C Weil; William Vainchenker
Expression of the c-fos protooncogene by human and murine erythroblasts.
Blood 1989;74(3):947-51.
1989: S Navarro; Najet Debili; J F Bernaudin; William Vainchenker; J Doly
Regulation of the expression of IL-6 in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4339-45.
1989: Jean-Luc Villeval; Caroline Le Van Kim; A Bettaieb; Najet Debili; Y Colin; B el Maliki; D Blanchard; William Vainchenker; J P Cartron
Early expression of glycophorin C during normal and leukemic human erythroid differentiation.
Cancer research 1989;49(10):2626-32.
1989: M T Mitjavila; M Natazawa; P Brignaschi; Najet Debili; J Breton-Gorius; William Vainchenker
Effects of five recombinant hematopoietic growth factors on enriched human erythroid progenitors in serum-replaced cultures.
Journal of cellular physiology 1989;138(3):617-23.
1989: J Breton-Gorius; Jean-Luc Villeval; NELLY KIEFFER; M T Mitjavila; Josette Guichard; William Vainchenker
Limits of phenotypic markers for the diagnosis of megakaryoblastic leukemia.
Blood cells 1989;15(1):259-77.
1988: G Vinci; Jean-Paul Vernant; M Nakazawa; M Zohair; A Katz; A Henri; H Rochant; J Breton-Gorius; William Vainchenker
In vitro inhibition of normal human hematopoiesis by marrow CD3+, CD8+, HLA-DR+, HNK1+ lymphocytes.
Blood 1988;72(5):1616-21.
1988: Françoise Farace; M T Mitjavila; A Betaieb; M C Dokhelar; Joëlle Wiels; Y Finale; NELLY KIEFFER; J Breton-Gorius; William Vainchenker; Thomas Tursz
New hematopoietic differentiation antigens detected by anti-K562 monoclonal antibodies.
Cancer research 1988;48(20):5759-65.
1988: NELLY KIEFFER; J L Wautier; Laure Coulombel; Monique Titeux; M P Wautier; William Vainchenker; C Ruan; J Breton-Gorius
Uncoupling in the expression of platelet GP IIb/IIIa in human endothelial cells and K562 cells: absence of immunologic crossreactivity between platelet GP IIb and the vitronectin receptor alpha chain.
Blood 1988;72(4):1209-15.
1988: I Max-Audit; D Kechemir; M T Mitjavila; William Vainchenker; D Rotten; R Rosa
Pyruvate kinase synthesis and degradation by normal and pathologic cells during erythroid maturation.
Blood 1988;72(3):1039-44.
1988: William Vainchenker; NELLY KIEFFER
Human megakaryocytopoiesis: in vitro regulation and characterization of megakaryocytic precursor cells by differentiation markers.
Blood reviews 1988;2(2):102-7.
1988: William Vainchenker; Jean-Luc Villeval; A Tabilio; H Matamis; G Karianakis; Josette Guichard; A Henri; Jean-Paul Vernant; H Rochant; J Breton-Gorius
Immunophenotype of leukemic blasts with small peroxidase-positive granules detected by electron microscopy.
Leukemia 1988;2(5):274-81.
1988: A Bettaieb; Françoise Farace; M T Mitjavila; Z Mishal; M C Dokhelar; Thomas Tursz; J Breton-Gorius; William Vainchenker; NELLY KIEFFER
Use of a monoclonal antibody (GA3) to demonstrate lineage restricted O-glycosylation on leukosialin during terminal erythroid differentiation.
Blood 1988;71(5):1226-33.
1988: M T Mitjavila; G Vinci; Jean-Luc Villeval; NELLY KIEFFER; A Henri; U Testa; J Breton-Gorius; William Vainchenker
Human platelet alpha granules contain a nonspecific inhibitor of megakaryocyte colony formation: its relationship to type beta transforming growth factor (TGF-beta).
Journal of cellular physiology 1988;134(1):93-100.
1987: A Bettaieb; Jean-Luc Villeval; NELLY KIEFFER; Françoise Farace; L Edelman; J P Cartron; William Vainchenker
Early erythroid markers as probes for normal and leukaemic erythroid differentiation.
Annales de l'Institut Pasteur. Immunology 1987;138(6):877-83.
1987: M T Mitjavila; Jean-Luc Villeval; P Cramer; A Henri; J Gasson; G Krystal; Micheline Tulliez; R Berger; J Breton-Gorius; William Vainchenker
Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias.
Blood 1987;70(4):965-73.
1987: P Cramer; William Vainchenker; Jean-Claude Brouet; Roland Berger
Cytogenetic study of myeloid and erythroid colonies in chronic myeloid leukaemia with stable Ph1 mosaicism.
British journal of haematology 1987;67(1):51-4.
1987: J Breton-Gorius; Jean-Luc Villeval; M T Mitjavila; G Vinci; Josette Guichard; H Rochant; G Flandrin; William Vainchenker
Ultrastructural and cytochemical characterization of blasts from early erythroblastic leukemias.
Leukemia 1987;1(3):173-81.
1987: J Breton-Gorius; J C Lewis; Josette Guichard; NELLY KIEFFER; William Vainchenker
Monoclonal antibodies specific for human platelet membrane glycoproteins bind to monocytes by focal absorption of platelet membrane fragments: an ultrastructural immunogold study.
Leukemia 1987;1(2):131-41.
1987: Micheline Tulliez; Jean-Luc Villeval; F Lejeune; A Henri; U Testa; Monique Titeux; H Rochant; J Breton-Gorius; William Vainchenker
Expression of blood group A antigen during erythroid differentiation in A1 and A2 subjects.
Leukemia 1987;1(1):44-51.
1987: G Vinci; Jean-Paul Vernant; C Cordonnier; A Henri; J Breton-Gorius; H Rochant; William Vainchenker
In vitro inhibition of hematopoiesis by HNK1, DR-positive T cells and monocytes after allogeneic bone marrow transplantation.
Experimental hematology 1987;15(1):54-64.
1986: P Edelman; G Vinci; Jean-Luc Villeval; William Vainchenker; A Henri; R Miglierina; P Rouger; J Reviron; J Breton-Gorius; C Sureau
A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors.
Blood 1986;67(1):56-63.
1986: William Vainchenker; NELLY KIEFFER; Elisabeth M Cramer; G Vinci; Najet Debili; A Henri; Monique Titeux; Josette Guichard; Z Mishal; J Breton-Gorius
Expression of platelet proteins during maturation of human megakaryocytes and of the K 562/HEL cell lines.
Progress in clinical and biological research 1986;215():227-40.
1985: Elisabeth M Cramer; William Vainchenker; G Vinci; Josette Guichard; J Breton-Gorius
Gray platelet syndrome: immunoelectron microscopic localization of fibrinogen and von Willebrand factor in platelets and megakaryocytes.
Blood 1985;66(6):1309-16.
1985: William Vainchenker; G Vinci; U Testa; A Henri; A Tabilio; M P Fache; H Rochant; J P Cartron
Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome.
The Journal of clinical investigation 1985;75(2):541-6.
1984: I Max-Audit; U Testa; D Kechemir; M Titeux; William Vainchenker; R Rosa
Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts.
Blood 1984;64(4):930-6.
1984: G Vinci; A Tabilio; J F Deschamps; D Van Haeke; A Henri; Josette Guichard; P Tetteroo; P M Lansdorp; T Hercend; William Vainchenker
Immunological study of in vitro maturation of human megakaryocytes.
British journal of haematology 1984;56(4):589-605.
1984: A Tabilio; William Vainchenker; D Van Haecke; G Vinci; Josette Guichard; A Henri; F Reyes; J Breton-Gorius
Immunological characterization of the leukemic megakaryocytic line at light and electron microscopic levels.
Leukemia research 1984;8(5):769-81.
1983: J Breton-Gorius; A Tabilio; William Vainchenker; G Vinci; D van Haeke; A Henri; Josette Guichard; M C Canizo
Diagnosis of megakaryoblastic leukemias.
Verhandlungen der Deutschen Gesellschaft für Pathologie 1983;67():166-81.
1983: J Breton-Gorius; D Vanhaeke; A Tabilio; William Vainchenker; J F Deschamps; F S Xu
Glycoprotein I identification during normal and pathological megakaryocytic maturation.
Blood cells 1983;9(2):275-91.
1982: U Testa; A Henri; A Bettaieb; Monique Titeux; William Vainchenker; H Tonthat; M C Docklear; H Rochant
Regulation of i- and I-antigen expression in the K562 cell line.
Cancer research 1982;42(11):4694-700.
1982: William Vainchenker; J Chapman; J F Deschamps; G Vinci; J Bouguet; Monique Titeux; J Breton-Gorius
Normal human serum contains a factor(s) capable of inhibiting megakaryocyte colony formation.
Experimental hematology 1982;10(8):650-60.
1982: U Testa; P Thomopoulos; G Vinci; Monique Titeux; A Bettaieb; William Vainchenker; H Rochant
Transferrin binding to K562 cell line. Effect of heme and sodium butyrate induction.
Experimental cell research 1982;140(2):251-60.
1982: William Vainchenker; Josette Guichard; J F Deschamps; J Bouguet; Monique Titeux; J Chapman; A J McMichael; J Breton-Gorius
Megakaryocyte cultures in the chronic phase and in the blast crisis of chronic myeloid leukaemia: studies on the differentiation of the megakaryocyte progenitors and on the maturation of megakaryocytes in vitro.
British journal of haematology 1982;51(1):131-46.
1982: William Vainchenker; U Testa; J F Deschamps; A Henri; Monique Titeux; J Breton-Gorius; H Rochant; D Lee; J P Cartron
Clonal expression of the Tn antigen in erythroid and granulocyte colonies and its application to determination of the clonality of the human megakaryocyte colony assay.
The Journal of clinical investigation 1982;69(5):1081-91.
1982: William Vainchenker; J F Deschamps; J M Bastin; Josette Guichard; Monique Titeux; J Breton-Gorius; A J McMichael
Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients.
Blood 1982;59(3):514-21.
1982: U Testa; William Vainchenker; Y Beuzard; Philippe Rouyer-Fessard; A Guerrasio; Monique Titeux; P Lapotre; J Bouguet; J Breton-Gorius; J Rosa
Hemoglobin expression in clones of K562 cell line.
European journal of biochemistry / FEBS 1982;121(3):649-55.
1982: M C Dokhelar; U Testa; William Vainchenker; Y Finale; C Tetaud; P Salem; Thomas Tursz
NK cell sensitivity of the leukemic K 562 cells; effect of sodium butyrate and hemin induction.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(1):211-6.
1982: U Testa; William Vainchenker; Y Beuzard; Philippe Rouyer-Fessard; Monique Titeux; J Bouguet; J Breton-Gorius; J Rosa
Hemoglobin expression in clones of K-562 cell line.
Birth defects original article series 1982;18(7):117-30.
1981: U Testa; A Henri; William Vainchenker; H Tonthat; Jean Riou; Y Beuzard; H Rochant; J Rosa
F-cells are preferentially distributed among high density erythrocytes.
Biomedicine / [publiée pour l'A.A.I.C.I.G.] 1981;35(3):94-7.
1981: A Tsapis; N Hinard; U Testa; Anne Dubart; William Vainchenker; Philippe Rouyer-Fessard; Y Beuzard; J Rosa
Study of hemoglobin synthesis by affinity chromatography on Sepharose haptoglobin.
Progress in clinical and biological research 1981;60():95-114.
1981: Y Beuzard; M Tulliez; U Testa; William Vainchenker; Anne Dubart; A Tsapis; F Galacteros; J Breton-Gorius; J Rosa
Beta-thalassemia and sickle cell disease in culture of early erythroid precursors: hemoglobin synthesis and ultrastructural study.
Blood cells 1981;7(1):179-200.
1981: William Vainchenker; U Testa; H Rochant; Monique Titeux; A Henri; J Bouguet; J Breton-Gorius
Cellular regulation of i and I antigen expressions in human erythroblasts grown in vitro.
Stem cells 1981;1(2):97-110.
1981: F Feuilhade; U Testa; William Vainchenker; A Henri; H T That; Y Beuzard; F Galacteros; B Dreyfus; H Rochant
Comparative patterns of i-antigen expression, F-cell frequency and Hb A2 level in acute myeloid leukemia and in acute lymphoid leukemia.
Leukemia research 1981;5(3):203-13.
1980: A Tsapis; N Hinard; U Testa; Anne Dubart; William Vainchenker; Philippe Rouyer-Fessard; Y Beuzard; J Rosa
Globin-chain affinity chromatography on Sepharose-haptoglobin: a new method of study of hemoglobin synthesis in reticulocytes, in bone marrow and in colonies of erythroid precursors.
European journal of biochemistry / FEBS 1980;112(3):513-9.
1980: H Rochant; U Testa; William Vainchenker; A Henri; Monique Titeux; H Tonthat; F Feuilhade
[Cellular regulation of the expression of i and I antigens during the in vitro differentiation of BFU-E].
Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles 1980;291(2):229-32.
1980: William Vainchenker; Josette Guichard; J Bouguet; J Breton-Gorius
Congenital dyserythropoietic anaemia type I: absence of clonal expression in the nuclear abnormalities of cultured erythroblasts.
British journal of haematology 1980;46(1):33-7.
1980: William Vainchenker; J Breton-Gorius; Josette Guichard; J Bouguet; A Henri; H Rochant; R Goudsmit
Congenital dyserythropoietic anemia type III. studies on erythroid differentiation of blood erythroid progenitor cells (BFUE) in vitro.
Experimental hematology 1980;8(8):1057-62.
1980: William Vainchenker; Anne Dubart; J Bouguet; U Testa; A Tsapis; H Tonthat; A Henri; N Monplaisir; Y Beuzard; H Rochant; J Rosa
Fetal hemoglobin synthesis in culture of early erythroid precursors (BFU-E) from the blood of normal adults.
Journal of cellular physiology 1980;102(3):297-303.
1980: A Henri; U Testa; H Tonthat; Jean Riou; Monique Titeux; William Vainchenker; F Feuilhade; F Galacteros; H Rochant
Disappearance of Hb F and i antigen during the first year of life.
American journal of hematology 1980;9(2):161-70.
1980: U Testa; Anne Dubart; N Hinard; F Galacteros; William Vainchenker; Philippe Rouyer-Fessard; Y Beuzard; J Rosa
Beta O-thalassemia/Hb E association. Hemoglobin synthesis in blood reticulocytes and bone marrow cells fractionated by density gradient and in blood erythroid colonies in culture.
Acta haematologica 1980;64(1):42-52.
1980: William Vainchenker; U Testa; N Hinard; Y Beuzard; Anne Dubart; A Tsapis; N Monplaisir; Philippe Rouyer-Fessard; J Rosa
Hemoglobin synthesis in 7-day and 14-day-old erythroid colonies from the bone marrow of normal individuals.
Hemoglobin 1980;4(1):53-67.