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Kestis Vaitkus

Research Profile

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Donald Lavelle; Yonghua Ling; Reda Mahfouz; Soledad Negrotto; Kwok Peng Ng; Maria A Ruiz; Kenneth K Chan; Joseph Covey; Joseph DeSimone; Kory J Engelke; Nicola Smith; Pramod Terse; Kestis Vaitkus; Yogen Saunthararajah
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine.
Donald Lavelle; Nadim Mahmud; Maria Armila Ruiz; Yogen Saunthararajah; Kestis Vaitkus; Vinzon Ibanez; Tatiana Kouznetsova; Joseph DeSimone
Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors.
Virryan Banzon; Vinzon Ibanez; Kestis Vaitkus; Maria Armila Ruiz; Kenneth Peterson; Joseph DeSimone; Donald Lavelle
siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures.

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All Publications

2012: Donald Lavelle; Yonghua Ling; Reda Mahfouz; Soledad Negrotto; Kwok Peng Ng; Maria A Ruiz; Kenneth K Chan; Joseph Covey; Joseph DeSimone; Kory J Engelke; Nicola Smith; Pramod Terse; Kestis Vaitkus; Yogen Saunthararajah
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine.
Blood 2012;119(5):1240-7.
2012: Donald Lavelle; Nadim Mahmud; Maria Armila Ruiz; Yogen Saunthararajah; Kestis Vaitkus; Vinzon Ibanez; Tatiana Kouznetsova; Joseph DeSimone
Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors.
PloS one 2012;7(5):e36846.
2011: Virryan Banzon; Vinzon Ibanez; Kestis Vaitkus; Maria Armila Ruiz; Kenneth Peterson; Joseph DeSimone; Donald Lavelle
siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures.
Experimental hematology 2011;39(1):26-36.e1.
2010: Imo Akpan; Virryan Banzon; Vinzon Ibanez; Kestis Vaitkus; Joseph DeSimone; Donald Lavelle
Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription.
Experimental hematology 2010;38(11):989-993.e1.
2010: Donald Lavelle; Yogen Saunthararajah; Kestis Vaitkus; Mahipal singh; Virryan Banzon; Pasit Phiasivongsva; Sanjeev Redkar; Sarath Kanekal; David J Bearss; Chongtie Shi; Roger Inloes; Joseph DeSimone
S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis).
Journal of translational medicine 2010;8():92.
2009: Janet Chin; Mahipal singh; Virryan Banzon; Kestis Vaitkus; Vinzon Ibanez; Tatiana Kouznetsova; Nadim Mahmud; Joseph DeSimone; Donald Lavelle
Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.
Experimental hematology 2009;37(10):1131-42.
2007: Donald Lavelle; Janet Chin; Kestis Vaitkus; Sanjeev Redkar; Pasit Phiasivongsa; Chunlin Tang; Roselle Will; Maria Hankewych; Bryan Roxas; Mahipal singh; Yogen Saunthararajah; Joseph DeSimone
Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis.
American journal of hematology 2007;82(11):981-5.
2007: Mahipal singh; Donald Lavelle; Kestis Vaitkus; Nadim Mahmud; Maria Hankewych; Joseph DeSimone
The gamma-globin gene promoter progressively demethylates as the hematopoietic stem progenitor cells differentiate along the erythroid lineage in baboon fetal liver and adult bone marrow.
Experimental hematology 2007;35(1):48-55.
2006: Donald Lavelle; Kestis Vaitkus; Maria Hankewych; Mahipal singh; Joseph DeSimone
Effect of 5-aza-2'-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin promoters in Papio anubis.
Experimental hematology 2006;34(3):339-47.
2006: Donald Lavelle; Kestis Vaitkus; Maria Hankewych; Mahipal singh; Joseph DeSimone
Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis.
Blood cells, molecules & diseases 2006;36(2):269-78.