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Ana Valdes

Research Profile

Physiology

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Genes & Molecular Sequences

Single Nucleotide Polymorphism

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Publications

TOP 3
Alireza Moayyeri; Christopher J Hammond; Ana M Valdes; Timothy D Spector
Cohort Profile: TwinsUK and healthy ageing twin study.
Ana M Valdes; Margaret Wheeler; Weiya Zhang; Nigel Arden; Cyrus Cooper; Sally Doherty; Rose A Maciewicz; Kenneth R Muir; M Doherty
Genetic contribution to radiographic severity in osteoarthritis of the knee.
F M K Williams; M Popham; D J Hart; E de Schepper; S Bierma-Zeinstra; Albert Hofman; André G Uitterlinden; N K Arden; C Cooper; Tim D Spector; Ana M Valdes; J van Meurs
GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women.

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All Publications

2013: Alireza Moayyeri; Christopher J Hammond; Ana M Valdes; Timothy D Spector
Cohort Profile: TwinsUK and healthy ageing twin study.
International journal of epidemiology 2013;42(1):76-85.
2012: Ana M Valdes; Margaret Wheeler; Weiya Zhang; Nigel Arden; Cyrus Cooper; Sally Doherty; Rose A Maciewicz; Kenneth R Muir; M Doherty
Genetic contribution to radiographic severity in osteoarthritis of the knee.
Annals of the rheumatic diseases 2012;71(9):1537-40.
2011: F M K Williams; M Popham; D J Hart; E de Schepper; S Bierma-Zeinstra; Albert Hofman; André G Uitterlinden; N K Arden; C Cooper; Tim D Spector; Ana M Valdes; J van Meurs
GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women.
Arthritis and rheumatism 2011;63(3):708-12.
2011: Ana M Valdes; Frances L Vaughn; Weiya Zhang; Nigel K Arden; Cyrus Cooper; Elaine M Dennison; Sally A Doherty; Mark H Edwards; Karen A Jameson; M Kassim Javaid; Paul E Leaverton; Rose A Maciewicz; Kenneth R Muir; Evadnie Rampersaud; Tim D Spector; Michael Doherty
Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain.
Arthritis care & research 2011;63(3):440-4.
2011: Toby Andrew; Cassandra D Calloway; Philip Chowienczyk; Gail Clement; Raj Gill; Sang Hoon Lee; Tim D Spector; Sarah Stuart; Ana M Valdes
A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity.
PloS one 2011;6(8):e22332.
2011: Ana M Valdes; Timothy J Vyse; Margaret Wheeler; Weiya Zhang; Cyrus Cooper; Elaine M Dennison; Michael Doherty; Sally A Doherty; Deborah J Hart; Thorvaldur Ingvarsson; Ingileif Jonsdottir; Gudbjorn F Jonsson; Helgi Jonsson; Irina Kerna; Kai E Kisand; Rose A Maciewicz; Massimo Mangino; Sarah Metrustry; David L Morris; Kenneth R Muir; Tim D Spector; Kari Stefansson; Unnur Styrkarsdottir; Agu Tamm; Ann Tamm; Nigel K Arden
Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.
PloS one 2011;6(8):e23371.
2011: Ana M Valdes; Tim D Spector
Genetic epidemiology of hip and knee osteoarthritis.
Nature reviews. Rheumatology 2011;7(1):23-32.
2010: Ana M Valdes; Nigel K Arden; A Tamm; Kai E Kisand; S Doherty; E Pola; Cyrus Cooper; A Tamm; K R Muir; I Kerna; D Hart; F O'Neil; W Zhang; Tim D Spector; R A Maciewicz; Michael Doherty
A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(5):699-704.
2010: Ana M Valdes; Tim D Spector
The genetic epidemiology of osteoarthritis.
Current opinion in rheumatology 2010;22(2):139-43.
2010: Ana M Valdes; Tim D Spector
The clinical relevance of genetic susceptibility to osteoarthritis.
Best practice & research. Clinical rheumatology 2010;24(1):3-14.
2009: Ana M Valdes; Tim D Spector; S Doherty; M Wheeler; D J Hart; M Doherty
Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations.
Annals of the rheumatic diseases 2009;68(12):1916-20.
2009: Guangju Zhai; J B J van Meurs; Gregory Livshits; I Meulenbelt; Ana M Valdes; N Soranzo; D Hart; F Zhang; Bernet S Kato; J B Richards; F M K Williams; M Inouye; M Kloppenburg; Panos Deloukas; E Slagboom; André G Uitterlinden; Tim D Spector
A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.
Journal of medical genetics 2009;46(9):614-6.
2009: Ana M Valdes; Timothy D Spector
The contribution of genes to osteoarthritis.
The Medical clinics of North America 2009;93(1):45-66, x.
2008: Ana M Valdes; Timothy D Spector
The contribution of genes to osteoarthritis.
Rheumatic diseases clinics of North America 2008;34(3):581-603.
2008: G Zhai; Deborah J Hart; Ana M Valdes; Bernet S Kato; J Brent Richards; A Hakim; Tim D Spector
Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008;19(8):1211-7.
2008: Ana M Valdes; John Loughlin; Kirsten M Timms; Joyce J B van Meurs; Lorraine Southam; Scott G Wilson; Sally Doherty; Rik J Lories; Frank P Luyten; Alexander Gutin; Victor Abkevich; Dongliang Ge; Albert Hofman; André G Uitterlinden; Deborah J Hart; Feng Zhang; Guangju Zhai; Rainer Egli; Michael Doherty; Jerry S Lanchbury; Tim D Spector
Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.
American journal of human genetics 2008;82(6):1231-40.
2008: J B Richards; Fernando Rivadeneira; M Inouye; T M Pastinen; N Soranzo; S G Wilson; T Andrew; Mario Falchi; Rhian Gwilliam; K R Ahmadi; Ana M Valdes; P Arp; P Whittaker; D J Verlaan; M Jhamai; V Kumanduri; M Moorhouse; J B van Meurs; Albert Hofman; H A P Pols; D Hart; G Zhai; Bernet S Kato; B H Mullin; F Zhang; P Deloukas; André G Uitterlinden; Tim D Spector
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.
Lancet 2008;371(9623):1505-12.
2007: Guangju Zhai; Ana M Valdes; Lynn F Cherkas; Gail Clement; David Strachan; Tim D Spector
The interaction of genes and smoking on forced expiratory volume: a classic twin study.
Chest 2007;132(6):1772-7.
2007: J Brent Richards; Ana M Valdes; Jeffrey P Gardner; Dimitri Paximadas; Masayuki Kimura; Ayrun Nessa; Xiaobin Lu; Gabriela L Surdulescu; Rami Swaminathan; Tim D Spector; Abraham Aviv
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.
The American journal of clinical nutrition 2007;86(5):1420-5.
2007: Ana M Valdes; J Brent Richards; Jeffrey P Gardner; R Swaminathan; Masayuki Kimura; L Xiaobin; Abraham Aviv; Tim D Spector
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2007;18(9):1203-10.
2007: Veronique Bataille; Bernet S Kato; Mario Falchi; Jeffrey Gardner; Masayuki Kimura; Marko Lens; Ursula Perks; Ana M Valdes; Dorothy C Bennett; Abraham Aviv; Tim D Spector
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(7):1499-502.
2007: J Brent Richards; Ana M Valdes; K Burling; Ursula Perks; Tim D Spector
Serum adiponectin and bone mineral density in women.
The Journal of clinical endocrinology and metabolism 2007;92(4):1517-23.
2007: Ana M Valdes; John Loughlin; Mark Van Oene; Kay Chapman; Gabriela L Surdulescu; Michael Doherty; Tim D Spector
Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee.
Arthritis and rheumatism 2007;56(1):137-46.
2006: Abraham Aviv; Ana M Valdes; Tim D Spector
Human telomere biology: pitfalls of moving from the laboratory to epidemiology.
International journal of epidemiology 2006;35(6):1424-9.
2006: Guangju Zhai; Abraham Aviv; D J Hunter; Deborah J Hart; Jeffrey P Gardner; Masayuki Kimura; X Lu; Ana M Valdes; Tim D Spector
Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study.
Annals of the rheumatic diseases 2006;65(11):1444-8.
2006: Lynn F Cherkas; Abraham Aviv; Ana M Valdes; J L Hunkin; Jeffrey P Gardner; Gabriela L Surdulescu; Masayuki Kimura; Tim D Spector
The effects of social status on biological aging as measured by white-blood-cell telomere length.
Aging cell 2006;5(5):361-5.
2006: Toby Andrew; Abraham Aviv; Mario Falchi; Gabriela L Surdulescu; Jeffrey P Gardner; Xiaobin Lu; Masayuki Kimura; Bernet S Kato; Ana M Valdes; Tim D Spector
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs.
American journal of human genetics 2006;78(3):480-6.
2006: Ana M Valdes; Mark Van Oene; Deborah J Hart; Gabriela L Surdulescu; John Loughlin; Michael Doherty; Tim D Spector
Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women.
Arthritis and rheumatism 2006;54(2):533-9.
2006: Tim D Spector; Rikard Reneland; Steven Mah; Ana M Valdes; Deborah J Hart; Stefan Kammerer; Maria Langdown; Carolyn R Hoyal; Josephine Atienza; Michael Doherty; Proton Rahman; Matthew Nelson; Andreas Braun
Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling.
Arthritis and rheumatism 2006;54(2):524-32.
2006: Abraham Aviv; Ana M Valdes; Jeffrey P Gardner; Rami Swaminathan; Masayuki Kimura; Tim D Spector
Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation.
The Journal of clinical endocrinology and metabolism 2006;91(2):635-40.
2005: Ana M Valdes; Geraldine Hassett; Deborah J Hart; Tim D Spector
Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort.
Spine 2005;30(21):2445-51.
2005: Ana M Valdes; Toby Andrew; Jeffrey P Gardner; M Kimura; E Oelsner; Lynn F Cherkas; Abraham Aviv; Tim D Spector
Obesity, cigarette smoking, and telomere length in women.
Lancet 2005;366(9486):662-4.
2004: Lynn F Cherkas; Elizabeth C Oelsner; Y T Mak; Ana M Valdes; Tim D Spector
Genetic influences on female infidelity and number of sexual partners in humans: a linkage and association study of the role of the vasopressin receptor gene (AVPR1A).
Twin research : the official journal of the International Society for Twin Studies 2004;7(6):649-58.
2004: Ana M Valdes; Deborah J Hart; Karen A Jones; Gabriela L Surdulescu; Peter Swarbrick; David V Doyle; Alan J Schafer; Tim D Spector
Association study of candidate genes for the prevalence and progression of knee osteoarthritis.
Arthritis and rheumatism 2004;50(8):2497-507.