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Roland Valdes

Research Profile

Chemicals & Drugs

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Pharmacogenetics

Physiology

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Publications

TOP 3
Rif S el-Mallakh; Marcus Stoddard; Saeed A Jortani; M Adnan el-Masri; Sandra Sephton; Roland Valdes
Aberrant regulation of endogenous ouabain-like factor in bipolar subjects.
Mark W Linder; Marjorie Bon Homme; Kristen K Reynolds; Brian F Gage; Charles S Eby; Natalia Silvestrov; Roland Valdes
Interactive modeling for ongoing utility of pharmacogenetic diagnostic testing: application for warfarin therapy.
Marjorie Bon Homme; Kristen K Reynolds; Roland Valdes; Mark W Linder
Dynamic pharmacogenetic models in anticoagulation therapy.

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All Publications

2010: Rif S el-Mallakh; Marcus Stoddard; Saeed A Jortani; M Adnan el-Masri; Sandra Sephton; Roland Valdes
Aberrant regulation of endogenous ouabain-like factor in bipolar subjects.
Psychiatry research 2010;178(1):116-20.
2009: Mark W Linder; Marjorie Bon Homme; Kristen K Reynolds; Brian F Gage; Charles S Eby; Natalia Silvestrov; Roland Valdes
Interactive modeling for ongoing utility of pharmacogenetic diagnostic testing: application for warfarin therapy.
Clinical chemistry 2009;55(10):1861-8.
2008: Marjorie Bon Homme; Kristen K Reynolds; Roland Valdes; Mark W Linder
Dynamic pharmacogenetic models in anticoagulation therapy.
Clinics in laboratory medicine 2008;28(4):539-52.
2008: Mohammad Al-Ghoul; Roland Valdes
Fundamentals of pharmacology and applications in pharmacogenetics.
Clinics in laboratory medicine 2008;28(4):485-97.
2008: Mohammad Al-Ghoul; Roland Valdes
Mammalian cardenolides in cancer prevention and therapeutics.
Therapeutic drug monitoring 2008;30(2):234-8.
2008: Alan H B Wu; Ping Wang; Andrew Smith; Christine Haller; Katherine Drake; Mark Linder; Roland Valdes
Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations.
Pharmacogenomics 2008;9(2):169-78.
2007: Edward P Womack; Kristen K Reynolds; Roland Valdes; Mark W Linder
Identification of a synonymous polymorphism within the cytochrome P4502C9 gene that interferes with identification of the CYP2C9*2 allele.
Therapeutic drug monitoring 2007;29(5):607-11.
2007: Yusheng Zhu; Michael Shennan; Kristen K Reynolds; Nancy A Johnson; Matthew R Herrnberger; Roland Valdes; Mark W Linder
Estimation of warfarin maintenance dose based on VKORC1 (-1639 G>A) and CYP2C9 genotypes.
Clinical chemistry 2007;53(7):1199-205.
2007: Kenneth Ihenetu; Hassan M Qazzaz; Fabian A Crespo; Rafael Fernandez-Botran; Roland Valdes
Digoxin-like immunoreactive factors induce apoptosis in human acute T-cell lymphoblastic leukemia.
Clinical chemistry 2007;53(7):1315-22.
2007: Michael J Pugia; Roland Valdes; Saeed A Jortani
Bikunin (urinary trypsin inhibitor): structure, biological relevance, and measurement.
Advances in clinical chemistry 2007;44():223-45.
2007: Rif S el-Mallakh; James Miller; Roland Valdes; Tamella Buss Cassis; Rena Li
Digoxin-like immunoreactive factor in human cerebrospinal fluid.
The Journal of neuropsychiatry and clinical neurosciences 2007;19(1):91.
2007: Michael J Pugia; Saeed A Jortani; Manju Basu; Ronald Sommer; Hai-Hang Kuo; Solomon Murphy; Doug Williamson; James Vranish; Patrick J Boyle; Danny Budzinski; Roland Valdes; Subhash C Basu
Immunological evaluation of urinary trypsin inhibitors in blood and urine: role of N- & O-linked glycoproteins.
Glycoconjugate journal 2007;24(1):5-15.
2006: Yusheng Zhu; Roland Valdes; Christine Q Simmons; Mark W Linder; Michael J Pugia; Saeed A Jortani
Analysis of ligand binding by bioaffinity mass spectrometry.
Clinica chimica acta; international journal of clinical chemistry 2006;371(1-2):71-8.
2006: Glen L Hortin; Saeed A Jortani; James Ritchie; Roland Valdes; Daniel W Chan
Proteomics: a new diagnostic frontier.
Clinical chemistry 2006;52(7):1218-22.
2006: Yusheng Zhu; David W Hein; Mark A Doll; Kristen K Reynolds; Ntei Abudu; Roland Valdes; Mark W Linder
Simultaneous determination of 7 N-acetyltransferase-2 single-nucleotide variations by allele-specific primer extension assay.
Clinical chemistry 2006;52(6):1033-9.
2006: Zahoor Shah; Saeed A Jortani; Riva Tauman; Roland Valdes; David Gozal
Serum proteomic patterns associated with sleep-disordered breathing in children.
Pediatric research 2006;59(3):466-70.
2005: Yusheng Zhu; Roland Valdes; Saeed A Jortani
Application of bioaffinity mass spectrometry for analysis of ligands.
Therapeutic drug monitoring 2005;27(6):694-9.
2004: Roland Valdes; Mark W Linder
Fine-tuning pharmacogenetics: paradigm for linking laboratory results to clinical action.
Clinical chemistry 2004;50(9):1498-9.
2004: Bonny Bukaveckas; Roland Valdes; Mark W Linder
Pharmacogenetics as related to the practice of cardiothoracic and vascular anesthesia.
Journal of cardiothoracic and vascular anesthesia 2004;18(3):353-65.
2004: Hassan M Qazzaz; Zhimin Cao; Duane Bolanowski; Barbara J Clark; Roland Valdes
De novo biosynthesis and radiolabeling of mammalian digitalis-like factors.
Clinical chemistry 2004;50(3):612-20.
2004: Michael J Pugia; Ronald Sommer; Paul Corey; Linda Anderson; Shannon Gleason; Saeed A Jortani; Ronald J Elin; Darryl L Gopual; Roland Valdes; John A Lott
The uristatin dipstick is useful in distinguishing upper respiratory from urinary tract infections.
Clinica chimica acta; international journal of clinical chemistry 2004;341(1-2):73-81.
2004: Rif S el-Mallakh; Mark Linder; Roland Valdes; Stephen Warwick Looney
Dialysis of saliva improves accuracy of saliva lithium determinations.
Bipolar disorders 2004;6(1):87-9.
2004: Tarek Elbeik; Johan Surtihadi; Mark Destree; Jed Gorlin; Mark Holodniy; Saeed A Jortani; Ken Kuramoto; Valerie Ng; Roland Valdes; Alexandra Valsamakis; Norah A Terrault
Multicenter evaluation of the performance characteristics of the bayer VERSANT HCV RNA 3.0 assay (bDNA).
Journal of clinical microbiology 2004;42(2):563-9.
2004: Saeed A Jortani; Sumanth D Prabhu; Roland Valdes
Strategies for developing biomarkers of heart failure.
Clinical chemistry 2004;50(2):265-78.
2004: Saeed A Jortani; Michael J Pugia; Ronald J Elin; Meera Thomas; Edward P Womack; Todd Cast; Roland Valdes
Sensitive noninvasive marker for the diagnosis of probable bacterial or viral infection.
Journal of clinical laboratory analysis 2004;18(6):289-95.
2004: Ling O Qiu; Mark W Linder; Deborah M Antonino-Green; Roland Valdes
Suppression of cytochrome P450 2E1 promoter activity by interferon-gamma and loss of response due to the -71G>T nucleotide polymorphism of the CYP2E1*7B allele.
The Journal of pharmacology and experimental therapeutics 2004;308(1):284-8.
2003: Roland Valdes; Mark W Linder; Saeed A Jortani
What is next in pharmacogenomics? Translating it to clinical practice.
Pharmacogenomics 2003;4(4):499-505.
2003: Roland Valdes; Mary O Huff; M Adnan el-Masri; Rif S el-Mallakh
Effect of ethacrynic acid on sodium pump alpha isoforms in SH-SY5Y cells.
Bipolar disorders 2003;5(2):123-8.
2003: Fermin Barrueto; Saeed A Jortani; Roland Valdes; Robert S Hoffman; Lewis S Nelson
Cardioactive steroid poisoning from an herbal cleansing preparation.
Annals of emergency medicine 2003;41(3):396-9.
2002: Mark W Linder; Stephen Warwick Looney; Jesse E Adams; Nancy Johnson; Deborah M Antonino-Green; Nichole Lacefield; Bonny Bukaveckas; Roland Valdes
Warfarin dose adjustments based on CYP2C9 genetic polymorphisms.
Journal of thrombosis and thrombolysis 2002;14(3):227-32.
2002: M Adnan el-Masri; Barbara J Clark; Hassan M Qazzaz; Roland Valdes
Human adrenal cells in culture produce both ouabain-like and dihydroouabain-like factors.
Clinical chemistry 2002;48(10):1720-30.
2002: Roland Valdes; Saeed A Jortani
Unexpected suppression of immunoassay results by cross-reactivity: now a demonstrated cause for concern.
Clinical chemistry 2002;48(3):405-6.
2001: Mark W Linder; Roland Valdes
Genetic mechanisms for variability in drug response and toxicity.
Journal of analytical toxicology 2001;25(5):405-13.
2001: Saeed A Jortani; Roland Valdes
Mammalian cardenolides as biomarkers in congestive heart failure.
Cardiovascular toxicology 2001;1(2):165-70.
2000: Saeed A Jortani; James W Snyder; Roland Valdes
The role of the clinical laboratory in managing chemical or biological terrorism.
Clinical chemistry 2000;46(12):1883-93.
2000: Hassan M Qazzaz; M Adnan el-Masri; Roland Valdes
Secretion of a lactone-hydrogenated ouabain-like effector of sodium, potassium-adenosine triphosphatase activity by adrenal cells.
Endocrinology 2000;141(9):3200-9.
2000: Mark W Linder; George M Bosse; M T Henderson; G Midkiff; Roland Valdes
Detection of cocaine metabolite in serum and urine: frequency and correlation with medical diagnosis.
Clinica chimica acta; international journal of clinical chemistry 2000;295(1-2):179-85.
2000: A M Rose; Hassan M Qazzaz; N Zolotarjova; B J Mellett; Alvin W Martin; Roland Valdes
Sodium pump isoforms in xenotransplantation: importance of biochemical compatibility.
Clinical chemistry 2000;46(2):234-41.
1999: Mark W Linder; Roland Valdes
Pharmacogenetics in the practice of laboratory medicine.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 1999;4(4):365-79.
1999: Hassan M Qazzaz; M Adnan el-Masri; Neal J Stolowich; Roland Valdes
Two biologically active isomers of dihydroouabain isolated from a commercial preparation.
Biochimica et biophysica acta 1999;1472(3):486-97.
1999: Z Cao; Mark W Linder; Anthony W Jevans; G Brown; Roland Valdes
Comparison of tacrolimus concentrations measured by the IMx tacrolimus II vs the PRO-TRAC II FK506 ELISA assays.
Clinical chemistry 1999;45(10):1868-70.
1999: G Grider; Rif S el-Mallakh; M O Huff; T J Buss; J Miller; Roland Valdes
Endogenous digoxin-like immunoreactive factor (DLIF) serum concentrations are decreased in manic bipolar patients compared to normal controls.
Journal of affective disorders 1999;54(3):261-7.
1999: Z Cao; R Bideau; Roland Valdes; Ronald J Elin
Acute hypermagnesemia and respiratory arrest following infusion of MgSO4 for tocolysis.
Clinica chimica acta; international journal of clinical chemistry 1999;285(1-2):191-3.
1999: Alan H B Wu; F S Apple; W B Gibler; Robert L Jesse; M M Warshaw; Roland Valdes
National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases.
Clinical chemistry 1999;45(7):1104-21.
1999: Roland Valdes; Saeed A Jortani
Standardizing utilization of biomarkers in diagnosis and management of acute cardiac syndromes.
Clinica chimica acta; international journal of clinical chemistry 1999;284(2):135-40.
1999: Saeed A Jortani; Ahmet Pinar; Nancy A Johnson; Roland Valdes
Validity of unbound digoxin measurements by immunoassays in presence of antidote (Digibind).
Clinica chimica acta; international journal of clinical chemistry 1999;283(1-2):159-69.
1999: Mark W Linder; Roland Valdes
Fundamentals and applications of pharmacogenetics for the clinical laboratory.
Annals of clinical and laboratory science 1999;29(2):140-9.
1999: Fred S Apple; Robert H Christenson; Roland Valdes; A J Andriak; A Berg; Show-Hong Duh; Y J Feng; Saeed A Jortani; Nancy A Johnson; B Koplen; Kristin Mascotti; Alan H B Wu
Simultaneous rapid measurement of whole blood myoglobin, creatine kinase MB, and cardiac troponin I by the triage cardiac panel for detection of myocardial infarction.
Clinical chemistry 1999;45(2):199-205.
1998: A M Rose; B J Mellett; Roland Valdes; J E Kleinman; M M Herman; Rena Li; Rif S el-Mallakh
Alpha 2 isoform of the Na,K-adenosine triphosphatase is reduced in temporal cortex of bipolar individuals.
Biological psychiatry 1998;44(9):892-7.
1998: Roland Valdes; Saeed A Jortani
Monitoring of unbound digoxin in patients treated with anti-digoxin antigen-binding fragments: a model for the future?
Clinical chemistry 1998;44(9):1883-5.
1998: Roland Valdes; Saeed A Jortani; Mihai Gheorghiade
Standards of laboratory practice: cardiac drug monitoring. National Academy of Clinical Biochemistry.
Clinical chemistry 1998;44(5):1096-109.
1997: A Gupta; P Joshi; Saeed A Jortani; Roland Valdes; T Thorkelsson; Zul Verjee; Sam D Shemie
A case of nondigitalis cardiac glycoside toxicity.
Therapeutic drug monitoring 1997;19(6):711-4.
1997: G A Hobbs; Saeed A Jortani; Roland Valdes
Implementation of a successful on-call system in clinical chemistry.
American journal of clinical pathology 1997;108(5):556-63.
1997: Saeed A Jortani; Daniel J Trepanier; Randall W Yatscoff; Roland Valdes
Convergence of three methods to resolve discrepant immunoassay digitoxin results.
Clinical chemistry 1997;43(9):1805-8.
1997: Mark W Linder; Russell A Prough; Roland Valdes
Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency.
Clinical chemistry 1997;43(2):254-66.
1997: Saeed A Jortani; Roland Valdes
Digoxin and its related endogenous factors.
Critical reviews in clinical laboratory sciences 1997;34(3):225-74.
1996: Saeed A Jortani; R A Helm; Roland Valdes
Inhibition of Na,K-ATPase by oleandrin and oleandrigenin, and their detection by digoxin immunoassays.
Clinical chemistry 1996;42(10):1654-8.
1996: H M Qazzaz; Saeed A Jortani; J M Poole; Roland Valdes
Evidence for presence of a reduced form of digoxin-like immunoreactive factor (dihydro-DLIF) in mammalian tissues.
Clinical chemistry 1996;42(7):1092-9.
1996: H M Qazzaz; S L Goudy; Roland Valdes
Deglycosylated products of endogenous digoxin-like immunoreactive factor in mammalian tissue.
The Journal of biological chemistry 1996;271(15):8731-7.
1996: H M Qazzaz; Roland Valdes
Simultaneous isolation of endogenous digoxin-like immunoreactive factor, ouabain-like factor, and deglycosylated congeners from mammalian tissues.
Archives of biochemistry and biophysics 1996;328(1):193-200.
1996: J J Miller; R W Straub; Roland Valdes
Analytical performance of a monoclonal digoxin assay with increased specificity on the ACS:180.
Therapeutic drug monitoring 1996;18(1):65-72.
1995: H M Qazzaz; S Goudy; J J Miller; Roland Valdes
Treatment of human serum with sulfosalicylic acid structurally alters digoxin and endogenous digoxin-like immunoreactive factor.
Therapeutic drug monitoring 1995;17(1):53-9.
1995: A M Rose; C Tongate; Roland Valdes
A hemoglobin A1C immunoassay method not affected by carbamylated hemoglobin.
Annals of clinical and laboratory science 1995;25(1):13-9.
1994: J J Miller; R W Straub; Roland Valdes
Digoxin immunoassay with cross-reactivity of digoxin metabolites proportional to their biological activity.
Clinical chemistry 1994;40(10):1898-903.
1994: A M Rose; Roland Valdes
Understanding the sodium pump and its relevance to disease.
Clinical chemistry 1994;40(9):1674-85.
1994: Mark W Linder; Roland Valdes
Mechanism and elimination of aspirin-induced interference in Emit II d.a.u. assays.
Clinical chemistry 1994;40(8):1512-6.
1994: A H Wu; Roland Valdes; Fred S Apple; T Gornet; M A Stone; S Mayfield-Stokes; A M Ingersoll-Stroubos; B Wiler
Cardiac troponin-T immunoassay for diagnosis of acute myocardial infarction.
Clinical chemistry 1994;40(6):900-7.
1994: R E Wagener; Mark W Linder; Roland Valdes
Decreased signal in Emit assays of drugs of abuse in urine after ingestion of aspirin: potential for false-negative results.
Clinical chemistry 1994;40(4):608-12.
1993: P P Hess; M A Stone; Roland Valdes
Demonstrating instrument-reagent flexibility: a carbamazepine enzyme immunoassay reagent system.
Therapeutic drug monitoring 1993;15(2):129-33.
1992: R W Hardy; R H Ng; R E Hill; S Walker; K M Sparks; S Kent; C Lakes; C E Hiar; Roland Valdes; B E Statland
A multicenter evaluation of lipid profiling with a compact analyzer (Miles Clinistat).
Clinical chemistry 1992;38(8 Pt 1):1437-9.
1992: Roland Valdes
Improving the specificity of digoxin immunoassays.
Wiener klinische Wochenschrift. Supplementum 1992;191():55-9.
1991: I M Shaikh; B W Lau; B A Siegfried; Roland Valdes
Isolation of digoxin-like immunoreactive factors from mammalian adrenal cortex.
The Journal of biological chemistry 1991;266(21):13672-8.
1991: J J Miller; Roland Valdes
Approaches to minimizing interference by cross-reacting molecules in immunoassays.
Clinical chemistry 1991;37(2):144-53.
1989: M L Matheke; Roland Valdes
A physician's office-based digoxin assay (Seralyzer) evaluated for interference by endogenous digoxin-like immunoreactive factors.
Annals of clinical and laboratory science 1989;19(3):168-74.
1988: B W Lau; Roland Valdes
Criteria for identifying endogenous compounds as digoxin-like immunoreactive factors in humans.
Clinica chimica acta; international journal of clinical chemistry 1988;175(1):67-77.
1988: T E Lackner; B W Lau; C Parvin; Roland Valdes
Endogenous digoxin-like immunoreactivity in elderly patients with normal serum creatinine concentrations.
Clinical pharmacy 1988;7(6):449-53.
1988: B A Siegfried; Roland Valdes
Excretion of endogenous digoxin-like immunoreactive factors in human urine is a function of urine flow rate.
Clinical chemistry 1988;34(5):960-4.
1988: Roland Valdes; James M. Hagberg; T E Vaughan; B W Lau; D R Seals; A A Ehsani
Endogenous digoxin-like immunoreactivity in blood is increased during prolonged strenuous exercise.
Life sciences 1988;42(1):103-10.
1987: W F Skogen; M R Rea; Roland Valdes
Improved interassay correlation of digoxin results in patients with and without renal failure by elimination of digoxin-like immunoreactive factors.
Clinical chemistry 1987;33(6):837-9.
1987: W F Skogen; M R Rea; Roland Valdes
Endogenous digoxin-like immunoreactive factors eliminated from serum samples by hydrophobic silica-gel extraction and enzyme immunoassay.
Clinical chemistry 1987;33(3):401-4.
1987: D M Delfert; M R Rea; G Kessler; B A Siegfried; Roland Valdes
Criteria for evaluating nonquantitative assays: application to serum choriogonadotropin.
Clinical chemistry 1987;33(1):150-3.
1986: R L Christensen; M R Rea; G Kessler; J P Crane; Roland Valdes
Implementation of a screening program for diagnosing open neural tube defects: selection, evaluation, and utilization of alpha-fetoprotein methodology.
Clinical chemistry 1986;32(10):1812-7.
1984: T E Lackner; Roland Valdes
Spurious digoxin concentrations.
European journal of clinical pharmacology 1984;26(4):531.
1983: R H Ng; B A Brown; Roland Valdes
Three commercial methods for serum ferritin compared and the high-dose "hook effect" eliminated.
Clinical chemistry 1983;29(6):1109-13.