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DA Vallera

Research Profile

Procedures

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Graft vs Host Disease

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Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; A H Sharpe; DA Vallera
Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells.
Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; H Yagita; Jonathan Bromberg; DA Vallera
A critical role for CD48 antigen in regulating alloengraftment and lymphohematopoietic recovery after bone marrow transplantation.
Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; S K Narula; S R Smith; M G Roncarolo; DA Vallera
Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease.

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All Publications

1999: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; A H Sharpe; DA Vallera
Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6368-77.
1998: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; H Yagita; Jonathan Bromberg; DA Vallera
A critical role for CD48 antigen in regulating alloengraftment and lymphohematopoietic recovery after bone marrow transplantation.
Blood 1998;92(11):4453-63.
1998: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; S K Narula; S R Smith; M G Roncarolo; DA Vallera
Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease.
Transplantation 1998;66(9):1220-9.
1998: Angela Panoskaltsis-Mortari; David L Lacey; DA Vallera; Bruce R Blazar
Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice.
Blood 1998;92(10):3960-7.
1998: Bruce R Blazar; Patricia A Taylor; Ron T McElmurry; L Tian; Angela Panoskaltsis-Mortari; S Lam; C Lees; Thomas J Waldschmidt; DA Vallera
Engraftment of severe combined immune deficient mice receiving allogeneic bone marrow via In utero or postnatal transfer.
Blood 1998;92(10):3949-59.
1998: William Murphy; Lisbeth A Welniak; D D Taub; Robert Wiltrout; Patricia A Taylor; DA Vallera; M Kopf; H Young; Dan Longo; Bruce R Blazar
Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice.
The Journal of clinical investigation 1998;102(9):1742-8.
1998: Bruce R Blazar; Patricia A Taylor; Randolph J Noelle; DA Vallera
CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses.
The Journal of clinical investigation 1998;102(3):473-82.
1998: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; DA Vallera
Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5355-65.
1997: Bruce R Blazar; Marc K Jenkins; Patricia A Taylor; J White; Angela Panoskaltsis-Mortari; Robert Korngold; DA Vallera
Anti-CD3 epsilon F(ab')2 fragments inhibit T cell expansion in vivo during graft-versus-host disease or the primary immune response to nominal antigen.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5821-33.
1997: Bruce R Blazar; Patricia A Taylor; M W Boyer; Angela Panoskaltsis-Mortari; J P Allison; DA Vallera
CD28/B7 interactions are required for sustaining the graft-versus-leukemia effect of delayed post-bone marrow transplantation splenocyte infusion in murine recipients of myeloid or lymphoid leukemia cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3460-73.
1997: Angela Panoskaltsis-Mortari; Patricia A Taylor; T M Yaeger; O Douglas Wangensteen; P B Bitterman; David H Ingbar; DA Vallera; Bruce R Blazar
The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide.
The Journal of clinical investigation 1997;100(5):1015-27.
1997: Bruce R Blazar; Patricia A Taylor; DA Vallera
CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients.
Transplantation 1997;64(4):571-6.
1997: Bruce R Blazar; Robert Korngold; DA Vallera
Recent advances in graft-versus-host disease (GVHD) prevention.
Immunological reviews 1997;157():79-109.
1997: M W Boyer; DA Vallera; Patricia A Taylor; G S Gray; E Katsanis; K Gorden; Paul J Orchard; Bruce R Blazar
The role of B7 costimulation by murine acute myeloid leukemia in the generation and function of a CD8+ T-cell line with potent in vivo graft-versus-leukemia properties.
Blood 1997;89(9):3477-85.
1997: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; J Buhlman; J Xu; R A Flavell; Robert Korngold; Randolph J Noelle; DA Vallera
Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):29-39.
1996: Bruce R Blazar; A H Sharpe; Patricia A Taylor; Angela Panoskaltsis-Mortari; G S Gray; Robert Korngold; DA Vallera
Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3250-9.
1996: Bruce R Blazar; Patricia A Taylor; J A Bluestone; DA Vallera
Murine gamma/delta-expressing T cells affect alloengraftment via the recognition of nonclassical major histocompatibility complex class Ib antigens.
Blood 1996;87(10):4463-72.
1996: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; S Sehgal; DA Vallera
In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A.
Blood 1996;87(9):4001-9.
1996: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; Terrence Anthony Barrett; J A Bluestone; DA Vallera
Lethal murine graft-versus-host disease induced by donor gamma/delta expressing T cells with specificity for host nonclassical major histocompatibility complex class Ib antigens.
Blood 1996;87(2):827-37.
1995: Bruce R Blazar; C A Brennan; H E Broxmeyer; L D Shultz; DA Vallera
Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo.
Experimental hematology 1995;23(13):1397-406.
1995: Bruce R Blazar; Patricia A Taylor; DA Vallera
In utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities.
Blood 1995;86(11):4353-66.
1995: Bruce R Blazar; Patricia A Taylor; Angela Panoskaltsis-Mortari; G S Gray; DA Vallera
Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts.
Blood 1995;85(9):2607-18.
1995: Bruce R Blazar; Patricia A Taylor; S Smith; DA Vallera
Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts.
Blood 1995;85(3):842-51.
1994: Bruce R Blazar; Patricia A Taylor; G S Gray; DA Vallera
The role of T cell subsets in regulating the in vivo efficacy of CTLA4-Ig in preventing graft-versus-host disease in recipients of fully MHC or multiple minor histocompatibility-disparate donor inocula.
Transplantation 1994;58(12):1422-6.
1994: Bruce R Blazar; Patricia A Taylor; W E Fitzsimmons; DA Vallera
FK506 inhibits graft-versus-host disease and bone marrow graft rejection in murine recipients of MHC disparate donor grafts by interfering with mature peripheral T cell expansion post-transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1836-46.
1994: Bruce R Blazar; Patricia A Taylor; P S Linsley; DA Vallera
In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice.
Blood 1994;83(12):3815-25.
1994: Bruce R Blazar; Patricia A Taylor; DA Vallera
In vivo or in vitro anti-CD3 epsilon chain monoclonal antibody therapy for the prevention of lethal murine graft-versus-host disease across the major histocompatibility barrier in mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3665-74.
1994: Bruce R Blazar; Patricia A Taylor; S N Sehgal; DA Vallera
Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow.
Blood 1994;83(2):600-9.
1993: Bruce R Blazar; Patricia A Taylor; D C Snover; S N Sehgal; DA Vallera
Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5726-41.
1993: Paul J Orchard; R A Detrick; K Gorden; C E Dunbar; DA Vallera; P Taylor; R S McIvor; Bruce R Blazar
Retroviral-mediated transfer of the murine interleukin-3 gene engineered for intracellular retention results in a myeloproliferative syndrome but is associated with circulating interleukin-3 levels.
Experimental hematology 1993;21(9):1245-54.
1993: Bruce R Blazar; Patricia A Taylor; S N Sehgal; DA Vallera
Rapamycin prolongs survival of murine recipients of fully allogeneic donor grafts when administered during the graft-versus-host disease process.
Annals of the New York Academy of Sciences 1993;685():73-85.
1993: Bruce R Blazar; Patricia A Taylor; D C Snover; J A Bluestone; DA Vallera
Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):265-77.
1993: Bruce R Blazar; P A Taylor; DA Vallera
In vivo T-cell receptor ligation facilitates alloengraftment and prevents lethal graft-versus-host disease (GVHD) in mice.
Bone marrow transplantation 1993;12 Suppl 3():S38-40.
1993: M T Poss; J L Swanson; Marilyn J Telen; L C Lasky; DA Vallera
Monoclonal antibody recognizing a unique Rh-related specificity.
Vox sanguinis 1993;64(4):231-9.
1992: Bruce R Blazar; M B Widmer; Patricia A Taylor; DA Vallera
Promotion of murine marrow alloengraftment and hematopoietic recovery across the major histocompatibility barrier by administration of recombinant human interleukin-1 alpha.
Blood 1992;80(6):1614-22.
1992: Bruce R Blazar; S L Aukerman; DA Vallera
Effect of recombinant human macrophage colony-stimulating factor in irradiated murine recipients of T-cell-depleted allogeneic or non-depleted syngeneic bone marrow transplants.
Blood 1992;79(6):1636-42.
1991: Bruce R Blazar; R Hirsch; R E Gress; S F Carroll; DA Vallera
In vivo administration of anti-CD3 monoclonal antibodies or immunotoxins in murine recipients of allogeneic T cell-depleted marrow for the promotion of engraftment.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1492-503.
1991: Daniel J Weisdorf; R Haake; Wesley J Miller; Philip B McGlave; T W LeBien; DA Vallera; L C Lasky; T H Kim; B A Peterson; Norma K C Ramsay
Autologous bone marrow transplantation for progressive non-Hodgkin's lymphoma: clinical impact of immunophenotype and in vitro purging.
Bone marrow transplantation 1991;8(2):135-42.
1990: Bruce R Blazar; D L Thiele; DA Vallera
Pretreatment of murine donor grafts with L-leucyl-L-leucine methyl ester: elimination of graft-versus-host disease without detrimental effects on engraftment.
Blood 1990;75(3):798-805.
1989: Bruce R Blazar; M B Widmer; David Cosman; H M Sassenfeld; DA Vallera
Improved survival and leukocyte reconstitution without detrimental effects on engraftment in murine recipients of human recombinant granulocyte colony-stimulating factor after transplantation of T-cell-depleted histoincompatible bone marrow.
Blood 1989;74(6):2264-9.
1989: Bruce R Blazar; John H Kersey; Philip B McGlave; DA Vallera; L C Lasky; R J Haake; Bruce C Bostrom; D R Weisdorf; C Epstein; Norma K C Ramsay
In vivo administration of recombinant human granulocyte/macrophage colony-stimulating factor in acute lymphoblastic leukemia patients receiving purged autografts.
Blood 1989;73(3):849-57.
1988: DA Vallera; Bruce R Blazar
Depressed leukocyte reconstitution and engraftment in murine recipients of T cell-depleted histoincompatible marrow pretreated with interleukin 3.
Transplantation 1988;46(4):616-20.
1988: Bruce R Blazar; M B Widmer; C C Soderling; S Gillis; DA Vallera
Enhanced survival but reduced engraftment in murine recipients of recombinant granulocyte/macrophage colony-stimulating factor following transplantation of T-cell-depleted histoincompatible bone marrow.
Blood 1988;72(4):1148-54.
1988: Bruce R Blazar; M B Widmer; John H Kersey; Norma K C Ramsay; Philip B McGlave; D L Urdal; S Gillis; C Henney; DA Vallera
Recombinant granulocyte/macrophage-colony stimulating factor in human and murine bone marrow transplantation.
Behring Institute Mitteilungen 1988;(83):170-80.
1988: Bruce R Blazar; C C Soderling; Leslie L Robison; DA Vallera
Short-course total-lymphoid irradiation combined with total-body irradiation to facilitate engraftment of T cell-depleted marrow across a major histocompatibility barrier in mice.
Transplantation 1988;46(2):324-7.
1988: Bruce R Blazar; C C Soderling; G C Koo; DA Vallera
Absence of a facilitory role for NK 1.1-positive donor cells in engraftment across a major histocompatibility barrier in mice.
Transplantation 1988;45(5):876-83.
1988: Bruce R Blazar; M B Widmer; C C Soderling; D L Urdal; S Gillis; Leslie L Robison; DA Vallera
Augmentation of donor bone marrow engraftment in histoincompatible murine recipients by granulocyte/macrophage colony-stimulating factor.
Blood 1988;71(2):320-8.