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François Vallette

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Chemicals & Drugs

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Publications

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Claire Pecqueur; Lisenn Lalier; Kristell Oizel; Lisa Oliver; François M Vallette
Targeting metabolism to induce cell death in cancer cells and cancer stem cells.
Lisa Oliver; Muriel Priault; Erika Hue; François M Vallette
Basal autophagy decreased during the differentiation of human adult mesenchymal stem cells.
Pierre-François Cartron; Emilie Debien; Eric Hervouet; Delphine Loussouarn; Jean Menanteau; Christophe Olivier; Daniel Pouliquen; Mario Campone; Stephane A Martin; François M Vallette
Folate supplementation limits the tumourigenesis in rodent models of gliomagenesis.

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All Publications

2013: Claire Pecqueur; Lisenn Lalier; Kristell Oizel; Lisa Oliver; François M Vallette
Targeting metabolism to induce cell death in cancer cells and cancer stem cells.
International journal of cell biology 2013;2013():805975.
2012: Lisa Oliver; Muriel Priault; Erika Hue; François M Vallette
Basal autophagy decreased during the differentiation of human adult mesenchymal stem cells.
Stem cells and development 2012;21(15):2779-88.
2012: Pierre-François Cartron; Emilie Debien; Eric Hervouet; Delphine Loussouarn; Jean Menanteau; Christophe Olivier; Daniel Pouliquen; Mario Campone; Stephane A Martin; François M Vallette
Folate supplementation limits the tumourigenesis in rodent models of gliomagenesis.
European journal of cancer (Oxford, England : 1990) 2012;48(15):2431-41.
2012: Marie Morfouace; Philippe Naveilhan; Lisa Oliver; Pascal Reynier; Muriel Bahut; Virginie Bonnamain; Naig Gueguen; Catherine Guette; Lisenn Lalier; François M Vallette
Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications.
The Journal of biological chemistry 2012;287(40):33664-74.
2012: Lisa Oliver; François Paris; Claire Pecqueur; Quentin Séry; Erika Hue; Audrey Lafargue; François M Vallette
Differentiation-related response to DNA breaks in human mesenchymal stem cells.
Stem cells (Dayton, Ohio) 2012;31(4):800-7.
2012: Pierre-François Cartron; Delphine Loussouarn; S A Martin; Mario Campone; François M Vallette
Prognostic impact of the expression/phosphorylation of the BH3-only proteins of the BCL-2 family in glioblastoma multiforme.
Cell death & disease 2012;3():e421.
2012: Eric Hervouet; Arulraj Nadaradjane; François M Vallette; Marine Gueguen; Pierre-François Cartron
Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle.
Cell division 2012;7():5.
2011: Lisenn Lalier; Pierre-François Cartron; Christophe Olivier; Cédric Logé; Gwenola Bougras; Jean-Michel Robert; Lisa Oliver; François M Vallette
Prostaglandins antagonistically control Bax activation during apoptosis.
Cell death and differentiation 2011;18(3):528-37.
2011: Freddy Gautier; Y Guillemin; Pierre-François Cartron; T Gallenne; N Cauquil; T Le Diguarher; P Casara; François M Vallette; S Manon; John A Hickman; Olivier Geneste; Philippe Juin
Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.
Molecular and cellular biology 2011;31(4):832-44.
2011: Lisa Oliver; Erika Hue; Julien Rossignol; Gwenola Bougras; Philippe Hulin; Philippe Naveilhan; Dominique Heymann; Laurent Lescaudron; François M Vallette
Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
PloS one 2011;6(5):e19820.
2011: Eric Hervouet; Philippe Hulin; François M Vallette; Pierre-François Cartron
Proximity ligation in situ assay for monitoring the global DNA methylation in cells.
BMC biotechnology 2011;11():31.
2010: Eric Hervouet; François M Vallette; Pierre-François Cartron
Dnmt1/Transcription factor interactions: an alternative mechanism of DNA methylation inheritance.
Genes & cancer 2010;1(5):434-43.
2010: Eric Hervouet; Lisenn Lalier; Emilie Debien; Mathilde Cheray; Audrey Geairon; Hélène Rogniaux; Delphine Loussouarn; Stéphane A Martin; François M Vallette; Pierre-François Cartron
Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells.
PloS one 2010;5(6):e11333.
2010: Muriel Priault; Erika Hue; Fanny Marhuenda; Paul Pilet; Lisa Oliver; François M Vallette
Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells.
PloS one 2010;5(1):e8755.
2009: Lisa Oliver; C Olivier; F B Marhuenda; Mario Campone; François M Vallette
Hypoxia and the malignant glioma microenvironment: regulation and implications for therapy.
Current molecular pharmacology 2009;2(3):263-84.
2009: Gaelle Brien; Anne-Laure Debaud; Xavier Robert; Lisa Oliver; Marie-Claude Trescol-Biemont; Nicolas Cauquil; O Geneste; Nushin Aghajari; François M Vallette; Richard Haser; Nathalie Bonnefoy-Berard
C-terminal residues regulate localization and function of the antiapoptotic protein Bfl-1.
The Journal of biological chemistry 2009;284(44):30257-63.
2009: Eric Hervouet; François M Vallette; Pierre-François Cartron
Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.
Epigenetics : official journal of the DNA Methylation Society 2009;4(7):487-99.
2009: Tristan Gallenne; Fabien Gautier; Lisa Oliver; Eric Hervouet; Belinda Noël; John A Hickman; Olivier Geneste; Pierre-François Cartron; François M Vallette; Stephen Manon; Philippe Juin
Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members.
The Journal of cell biology 2009;185(2):279-90.
2008: Pierre-François Cartron; Gregory Bellot; Lisa Oliver; Xavier Grandier-Vazeille; Stéphen Manon; François M Vallette
Bax inserts into the mitochondrial outer membrane by different mechanisms.
FEBS letters 2008;582(20):3045-51.
2007: Nadine Platet; Shi Yong Liu; Michèle El Atifi; Lisa Oliver; François M Vallette; François Berger; didier wion
Influence of oxygen tension on CD133 phenotype in human glioma cell cultures.
Cancer letters 2007;258(2):286-90.
2007: Hubert Arokium; Hakim Ouerfelli; Gisèle Velours; Nadine Camougrand; François M Vallette; Stéphen Manon
Substitutions of potentially phosphorylatable serine residues of Bax reveal how they may regulate its interaction with mitochondria.
The Journal of biological chemistry 2007;282(48):35104-12.
2007: Emine Er; Lisenn Lalier; Pierre-François Cartron; Lisa Oliver; François M Vallette
Control of Bax homodimerization by its carboxyl terminus.
The Journal of biological chemistry 2007;282(34):24938-47.
2007: Lisenn Lalier; Pierre-François Cartron; F Pedelaborde; Christophe Olivier; D Loussouarn; S A Martin; Khaled Meflah; Jean Menanteau; François M Vallette
Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme.
Oncogene 2007;26(34):4999-5009.
2007: Lisa Oliver; Béatrice Mahé; René Gréé; François M Vallette; Philippe Juin
HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells.
Leukemia research 2007;31(6):859-63.
2007: Lisenn Lalier; Pierre-François Cartron; Philippe Juin; Svetlana Nedelkina; Stéphen Manon; Burkhart Bechinger; François M Vallette
Bax activation and mitochondrial insertion during apoptosis.
Apoptosis : an international journal on programmed cell death 2007;12(5):887-96.
2007: Gregory Bellot; Pierre-François Cartron; Emine Er; Lisa Oliver; Philippe Juin; Lucas C Armstrong; P Bornstein; K Mihara; Stéphen Manon; François M Vallette
TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.
Cell death and differentiation 2007;14(4):785-94.
2006: Maude Pelletier; Julien Rossignol; Lisa Oliver; Maryvonne Zampieri; Josiane Fontaine-Pérus; François M Vallette; Laurent Lescaudron
Soluble factors from neuronal cultures induce a specific proliferation and resistance to apoptosis of cognate mouse skeletal muscle precursor cells.
Neuroscience letters 2006;407(1):20-5.
2006: Emine Er; Lisa Oliver; Pierre-François Cartron; Philippe Juin; Stéphen Manon; François M Vallette
Mitochondria as the target of the pro-apoptotic protein Bax.
Biochimica et biophysica acta 2006;1757(9-10):1301-11.
2006: Florence Manero; Fabien Gautier; Tristan Gallenne; Nicolas Cauquil; Danielle Grée; Pierre-François Cartron; Olivier Geneste; René Grée; François M Vallette; Philippe Juin
The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.
Cancer research 2006;66(5):2757-64.
2006: D Pouliquen; Gregory Bellot; Gilles Guihard; P Fichet; Khaled Meflah; François M Vallette
Mitochondrial membrane permeabilization produced by PTP, Bax and apoptosis: a 1H-NMR relaxation study.
Cell death and differentiation 2006;13(2):301-10.
2006: Daniel Pouliquen; Christophe Olivier; Emilie Debien; Khaled Meflah; François M Vallette; Jean Menanteau
Changes in liver mitochondrial plasticity induced by brain tumor.
BMC cancer 2006;6():234.
2005: Muriel Priault; Bénédicte Salin; J Schaeffer; François M Vallette; Jean-Paul di Rago; Jean-Claude Martinou
Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast.
Cell death and differentiation 2005;12(12):1613-21.
2005: Anne-Laure Genestier; Marie-Cécile Michallet; Gilles Prévost; Gregory Bellot; Lara Chalabreysse; Simone Peyrol; Françoise Thivolet; Jerome Etienne; Gerard Lina; François M Vallette; François Vandenesch; Laurent Genestier
Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils.
The Journal of clinical investigation 2005;115(11):3117-27.
2005: Lisa Oliver; François M Vallette
The role of caspases in cell death and differentiation.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(3):163-70.
2005: Philippe Juin; Pierre-François Cartron; François M Vallette
Activation of Bax by BH3 domains during apoptosis: the unfolding of a deadly plot.
Cell cycle (Georgetown, Tex.) 2005;4(5):637-42.
2005: Maude Pelletier; Lisa Oliver; Khaled Meflah; François M Vallette
Caspase-3 can be pseudo-activated by a Ca2+-dependent proteolysis at a non-canonical site.
FEBS letters 2005;579(11):2364-8.
2005: Pierre-François Cartron; Hubert Arokium; Lisa Oliver; Khaled Meflah; Stéphen Manon; François M Vallette
Distinct domains control the addressing and the insertion of Bax into mitochondria.
The Journal of biological chemistry 2005;280(11):10587-98.
2005: Lisa Oliver; Marie-Thérèse LeCabellec; Gilbert Pradal; Khaled Meflah; G Kroemer; François M Vallette
Constitutive presence of cytochrome c in the cytosol of a chemoresistant leukemic cell line.
Apoptosis : an international journal on programmed cell death 2005;10(2):277-87.
2004: Hubert Arokium; Nadine Camougrand; François M Vallette; Stéphen Manon
Studies of the interaction of substituted mutants of BAX with yeast mitochondria reveal that the C-terminal hydrophobic alpha-helix is a second ART sequence and plays a role in the interaction with anti-apoptotic BCL-xL.
The Journal of biological chemistry 2004;279(50):52566-73.
2004: Pierre-François Cartron; Lisa Oliver; Ebrahim Mayat; Khaled Meflah; François M Vallette
Impact of pH on Bax alpha conformation, oligomerisation and mitochondrial integration.
FEBS letters 2004;578(1-2):41-6.
2004: Pierre-François Cartron; Tristan Gallenne; Gwenola Bougras; Fabien Gautier; Florence Manero; Patricia Vusio; Khaled Meflah; François M Vallette; Philippe Juin
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.
Molecular cell 2004;16(5):807-18.
2004: Gilles Guihard; Gregory Bellot; Carole Moreau; Gilbert Pradal; Nicolas Ferry; Raphael Thomy; Paulette Fichet; Khaled Meflah; François M Vallette
The mitochondrial apoptosis-induced channel (MAC) corresponds to a late apoptotic event.
The Journal of biological chemistry 2004;279(45):46542-50.
2004: Sandra Frank; Lisa Oliver; Corinne Lebreton-De Coster; Carole Moreau; Marie-Thérèse LeCabellec; Laurence Michel; François M Vallette; Louis Dubertret; Bernard Coulomb
Infrared radiation affects the mitochondrial pathway of apoptosis in human fibroblasts.
The Journal of investigative dermatology 2004;123(5):823-31.
2004: Céline Chipoy; Martine Berreur; Séverine Couillaud; Gilbert Pradal; François M Vallette; Caroline Colombeix; Françoise Rédini; Dominique Heymann; Frédéric Blanchard
Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(11):1850-61.
2004: Gwenola Bougras; Pierre-François Cartron; Fabien Gautier; Stéphane Martin; Marie-Thérèse LeCabellec; Khaled Meflah; Marc Gregoire; François M Vallette
Opposite role of Bax and BCL-2 in the anti-tumoral responses of the immune system.
BMC cancer 2004;4():54.
2004: Delphine Poncet; Nathanael Larochette; Anne-Laure Pauleau; Marian Mellen; Abdelali JALIL; Pierre-Francois Cartron; François M Vallette; Céline Schnebelen; Laura M Bartle; Anna Skaletskaya; David Boutolleau; Jean-Claude Martinou; Victor S Goldmacher; Guido Kroemer; Naoufal Zamzami
An anti-apoptotic viral protein that recruits Bax to mitochondria.
The Journal of biological chemistry 2004;279(21):22605-14.
2004: Maude Pelletier; Pierre-François Cartron; Floriane Delaval; Khaled Meflah; François M Vallette; Lisa Oliver
Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit.
Biochemical and biophysical research communications 2004;316(1):93-9.
2004: Pierre-François Cartron; Lisa Oliver; Philippe Juin; Khaled Meflah; François M Vallette
The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein.
The Journal of biological chemistry 2004;279(12):11503-12.
2003: Muriel Priault; Nadine Camougrand; Kathleen W Kinnally; François M Vallette; Stéphen Manon
Yeast as a tool to study Bax/mitochondrial interactions in cell death.
FEMS yeast research 2003;4(1):15-27.
2003: Muriel Priault; Pierre-François Cartron; Nadine Camougrand; Bruno Antonsson; François M Vallette; Stéphen Manon
Investigation of the role of the C-terminus of Bax and of tc-Bid on Bax interaction with yeast mitochondria.
Cell death and differentiation 2003;10(9):1068-77.
2003: Pierre-François Cartron; Philippe Juin; Lisa Oliver; Khaled Meflah; François M Vallette
Impact of proapoptotic proteins Bax and Bak in tumor progression and response to treatment.
Expert review of anticancer therapy 2003;3(4):563-70.
2003: Pierre-François Cartron; Philippe Juin; Lisa Oliver; Stéphane Martin; Khaled Meflah; François M Vallette
Nonredundant role of Bax and Bak in Bid-mediated apoptosis.
Molecular and cellular biology 2003;23(13):4701-12.
2003: Carole Moreau; Pierre-François Cartron; Abigail Hunt; Khaled Meflah; Douglas R Green; Gerard I Evan; François M Vallette; Philippe Juin
Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins.
The Journal of biological chemistry 2003;278(21):19426-35.
2003: Pierre-François Cartron; Muriel Priault; Lisa Oliver; Khaled Meflah; Stéphen Manon; François M Vallette
The N-terminal end of Bax contains a mitochondrial-targeting signal.
The Journal of biological chemistry 2003;278(13):11633-41.
2003: Dorian McIlroy; Pierre-François Cartron; Pierre Tuffery; Yasmine Dudoit; Assia Samri; Brigitte Autran; François M Vallette; Patrice Debré; Ioannis Theodorou
A triple-mutated allele of granzyme B incapable of inducing apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2562-7.
2002: Lisa Oliver; Fabienne Vavasseur; Beatrice Mahé; Pascale Perrin; Jean-Luc Harousseau; Khaled Meflah; François M Vallette
Assessment of caspase activity as a possible prognostic factor in acute myeloid leukaemia.
British journal of haematology 2002;118(2):434-7.
2002: Pierre-François Cartron; Lisa Oliver; Stéphane Martin; Carole Moreau; Marie-Thérèse LeCabellec; Pascal Jezequel; Khaled Meflah; François M Vallette
The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients.
Human molecular genetics 2002;11(6):675-87.
2002: Jean-Marc Philippe; Jean-Marc Dubois; Béatrice Rouzaire-Dubois; Pierre-François Cartron; François M Vallette; Nicolas Morel
Functional expression of V-ATPases in the plasma membrane of glial cells.
Glia 2002;37(4):365-73.
2002: Pierre-François Cartron; Carole Moreau; Lisa Oliver; Ebrahim Mayat; Khaled Meflah; François M Vallette
Involvement of the N-terminus of Bax in its intracellular localization and function.
FEBS letters 2002;512(1-3):95-100.
2002: Lisa Oliver; Sandrine Cordel; Isabelle Barbieux; Marie-Thérèse LeCabellec; Khaled Meflah; Marc Grégoire; François M Vallette
Resistance to apoptosis is increased during metastatic dissemination of colon cancer.
Clinical & experimental metastasis 2002;19(2):175-80.
2001: M Campone; Fabienne Vavasseur; M T Le Cabellec; Khaled Meflah; François M Vallette; Lisa Oliver
Induction of chemoresistance in HL-60 cells concomitantly causes a resistance to apoptosis and the synthesis of P-glycoprotein.
Leukemia 2001;15(9):1377-87.
2001: S Martin; C Toquet; Lisa Oliver; Pierre-François Cartron; Pascale Perrin; Khaled Meflah; P Cuillère; François M Vallette
Expression of bcl-2, bax and bcl-xl in human gliomas: a re-appraisal.
Journal of neuro-oncology 2001;52(2):129-39.
2000: Lisa Oliver; Muriel Priault; K Tremblais; Marie-Thérèse LeCabellec; Khaled Meflah; Stéphen Manon; François M Vallette
The substitution of the C-terminus of bax by that of bcl-xL does not affect its subcellular localization but abrogates its pro-apoptotic properties.
FEBS letters 2000;487(2):161-5.
2000: Lisa Oliver; K Tremblais; N Guriec; S Martin; Khaled Meflah; Jean Menanteau; François M Vallette
Influence of bcl-2-related proteins on matrix metalloproteinase expression in a rat glioma cell line.
Biochemical and biophysical research communications 2000;273(2):411-6.
1999: K Tremblais; Lisa Oliver; Philippe Juin; T M Le Cabellec; Khaled Meflah; François M Vallette
The C-terminus of bax is not a membrane addressing/anchoring signal.
Biochemical and biophysical research communications 1999;260(3):582-91.
1998: Philippe Juin; K Tremblais; Marie-Thérèse LeCabellec; Marc Grégoire; Khaled Meflah; François M Vallette
Potentiation of apoptosis by mitochondria in a cell-free system.
Biochemical and biophysical research communications 1998;253(1):185-91.
1998: Philippe Juin; Maude Pelletier; Lisa Oliver; K Tremblais; Marc Grégoire; Khaled Meflah; François M Vallette
Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system.
The Journal of biological chemistry 1998;273(28):17559-64.
1997: Philippe Juin; M Thieffry; JP Henry; François M Vallette
Relationship between the peptide-sensitive channel and the mitochondrial outer membrane protein translocation machinery.
The Journal of biological chemistry 1997;272(9):6044-50.
1997: O Boisteau; Fabien Gautier; Sandrine Cordel; Frédéric Henry; Jean Harb; J Y Douillard; François M Vallette; Khaled Meflah; Marc Grégoire
Apoptosis induced by sodium butyrate treatment increases immunogenicity of a rat colon tumor cell line.
Apoptosis : an international journal on programmed cell death 1997;2(4):403-12.
1996: Jean-Pierre Henry; Philippe Juin; François M Vallette; M Thieffry
Characterization and function of the mitochondrial outer membrane peptide-sensitive channel.
Journal of bioenergetics and biomembranes 1996;28(2):101-8.
1995: Philippe Juin; M Pelleschi; Corinne Sagné; Jean-Pierre Henry; M Thieffry; François M Vallette
Involvement of the peptide sensitive channel in the translocation of basic peptides into mitochondria.
Biochemical and biophysical research communications 1995;211(1):92-9.
1994: François M Vallette; Philippe Juin; M Pelleschi; Jean-Pierre Henry
Basic peptides can be imported into yeast mitochondria by two distinct targeting pathways. Involvement of the peptide-sensitive channel of the outer membrane.
The Journal of biological chemistry 1994;269(18):13367-74.