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Danila Valmori

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Disorders

Melanoma

Genes & Molecular Sequences

Amino Acid Sequence

Physiology

Concepts & Ideas

Molecular Sequence Data

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Publications

TOP 3
Bioley Gilles; Dousset Christelle; Yeh Alice; Dupont Bo; Bhardwaj Nina; Mears Gregory; Old Lloyd J; Ayyoub Maha; Valmori Danila
Vaccination with recombinant NY-ESO-1 protein elicits immunodominant HLA-DR52b-restricted CD4+ T cell responses with a conserved T cell receptor repertoire.
Qian Feng; Villella Jeannine; Wallace Paul K; Mhawech-Fauceglia Paulette; Tario Joseph D; Andrews Christopher; Matsuzaki Junko; Valmori Danila; Ayyoub Maha; Frederick Peter J; Beck Amy; Liao Jianqun; Cheney Richard; Moysich Kirsten; Lele Shashikant; Shrikant Protul; Old Lloyd J; Odunsi Kunle
Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer.
Ayyoub Maha; Deknuydt Florence; Raimbaud Isabelle; Dousset Christelle; Leveque Lucie; Bioley Gilles; Valmori Danila
Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t.

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All Publications

2009: Bioley Gilles; Dousset Christelle; Yeh Alice; Dupont Bo; Bhardwaj Nina; Mears Gregory; Old Lloyd J; Ayyoub Maha; Valmori Danila
Vaccination with recombinant NY-ESO-1 protein elicits immunodominant HLA-DR52b-restricted CD4+ T cell responses with a conserved T cell receptor repertoire.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4467-74.
2009: Qian Feng; Villella Jeannine; Wallace Paul K; Mhawech-Fauceglia Paulette; Tario Joseph D; Andrews Christopher; Matsuzaki Junko; Valmori Danila; Ayyoub Maha; Frederick Peter J; Beck Amy; Liao Jianqun; Cheney Richard; Moysich Kirsten; Lele Shashikant; Shrikant Protul; Old Lloyd J; Odunsi Kunle
Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer.
Cancer research 2009;69(13):5498-504.
2009: Ayyoub Maha; Deknuydt Florence; Raimbaud Isabelle; Dousset Christelle; Leveque Lucie; Bioley Gilles; Valmori Danila
Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(21):8635-40.
2009: Deknuydt Florence; Bioley Gilles; Valmori Danila; Ayyoub Maha
IL-1beta and IL-2 convert human Treg into T(H)17 cells.
Clinical immunology (Orlando, Fla.) 2009;131(2):298-307.
2009: Bioley Gilles; Guillaume Philippe; Luescher Immanuel; Bhardwaj Nina; Mears Gregory; Old Lloyd; Valmori Danila; Ayyoub Maha
Vaccination with a recombinant protein encoding the tumor-specific antigen NY-ESO-1 elicits an A2/157-165-specific CTL repertoire structurally distinct and of reduced tumor reactivity than that elicited by spontaneous immune responses to NY-ESO-1-expressing Tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(2):161-8.
2009: Leveque Lucie; Deknuydt Florence; Bioley Gilles; Old Lloyd J; Matsuzaki Junko; Odunsi Kunle; Ayyoub Maha; Valmori Danila
Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(2):101-8.
2009: Bioley Gilles; Guillaume Philippe; Luescher Immanuel; Yeh Alice; Dupont Bo; Bhardwaj Nina; Mears Gregory; Old Lloyd J; Valmori Danila; Ayyoub Maha
HLA class I - associated immunodominance affects CTL responsiveness to an ESO recombinant protein tumor antigen vaccine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(1):299-306.
2008: Garcia Casado Javier; Janda Jozef; Wei Joe; Chapatte Laurence; Colombetti Sara; Alves Pedro; Ritter Gerd; Ayyoub Maha; Valmori Danila; Chen Weisan; Lévy Frédéric
Lentivector immunization induces tumor antigen-specific B and T cell responses in vivo.
European journal of immunology 2008;38(7):1867-76.
2008: Tosello Valeria; Odunsi Kunle; Souleimanian Naira E; Lele Shashikant; Shrikant Protul; Old Lloyd J; Valmori Danila; Ayyoub Maha
Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs.
Clinical immunology (Orlando, Fla.) 2008;126(3):291-302.
2008: Susumu Seiya; Nagata Yasuhiro; Ito Shinichiro; Matsuo Mitsutoshi; Valmori Danila; Yui Katsuyuki; Udono Heiichiro; Kanematsu Takashi
Cross-presentation of NY-ESO-1 cytotoxic T lymphocyte epitope fused to human heat shock cognate protein 70 by dendritic cells.
Cancer science 2008;99(1):107-12.
2007: Godefroy Emmanuelle; Wang Yu; Souleimanian Naira E; Scotto Luigi; Stevanovic Stefan; Chen Yao-Tseng; Valmori Danila; Ayyoub Maha
Assessment of CD4+ T cells specific for the tumor antigen SSX-1 in cancer-free individuals.
Cancer immunology, immunotherapy : CII 2007;56(8):1183-92.
2007: Valmori Danila; Souleimanian Naira E; Tosello Valeria; Bhardwaj Nina; Adams Sylvia; O'Neill David; Pavlick Anna; Escalon Juliet B; Cruz Crystal M; Angiulli Angelica; Angiulli Francesca; Mears Gregory; Vogel Susan M; Pan Linda; Jungbluth Achim A; Hoffmann Eric W; Venhaus Ralph; Ritter Gerd; Old Lloyd J; Ayyoub Maha
Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8947-52.
2007: Le Gal Frédérique-Anne; Widmer Valérie M; Dutoit Valérie; Rubio-Godoy Verena; Schrenzel Jacques; Walker Paul R; Romero Pedro J; Valmori Danila; Speiser Daniel E; Dietrich Pierre-Yves
Tissue homing and persistence of defined antigen-specific CD8+ tumor-reactive T-cell clones in long-term melanoma survivors.
The Journal of investigative dermatology 2007;127(3):622-9.
2007: Valmori Danila; Lévy Frédéric; Godefroy Emmanuelle; Scotto Luigi; Souleimanian Naira E; Karbach Julia; Tosello Valeria; Hesdorffer Charles S; Old Lloyd J; Jager Elke; Ayyoub Maha
Epitope clustering in regions undergoing efficient proteasomal processing defines immunodominant CTL regions of a tumor antigen.
Clinical immunology (Orlando, Fla.) 2007;122(2):163-72.
2006: Godefroy Emmanuelle; Scotto Luigi; Souleimanian Naira E; Ritter Gerd; Old Lloyd J; Jotereau Francine; Valmori Danila; Ayyoub Maha
Identification of two Melan-A CD4+ T cell epitopes presented by frequently expressed MHC class II alleles.
Clinical immunology (Orlando, Fla.) 2006;121(1):54-62.
2006: Jäger Elke; Karbach Julia; Gnjatic Sacha; Neumann Antje; Bender Armin; Valmori Danila; Ayyoub Maha; Ritter Erika; Ritter Gerd; Jäger Dirk; Panicali Dennis; Hoffman Eric; Pan Linda; Oettgen Herbert; Old Lloyd J; Knuth Alexander
Recombinant vaccinia/fowlpox NY-ESO-1 vaccines induce both humoral and cellular NY-ESO-1-specific immune responses in cancer patients.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14453-8.
2006: Ye Sheng-Wei; Wang Yu; Valmori Danila; Ayyoub Maha; Han Yan; Xu Xiao-Lan; Zhao Ai-Lian; Qu Li; Gnjatic Sacha; Ritter Gerd; Old Lloyd J; Gu Jin
Ex-vivo analysis of CD8+ T cells infiltrating colorectal tumors identifies a major effector-memory subset with low perforin content.
Journal of clinical immunology 2006;26(5):447-56.
2006: Valmori Danila; Tosello Valeria; Souleimanian Naira E; Godefroy Emmanuelle; Scotto Luigi; Wang Yu; Ayyoub Maha
Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):944-9.
2006: Chapatte Laurence; Ayyoub Maha; Morel Sandra; Peitrequin Anne-Lise; Lévy Nicole; Servis Catherine; Van den Eynde Benoît J; Valmori Danila; Lévy Frédéric
Processing of tumor-associated antigen by the proteasomes of dendritic cells controls in vivo T-cell responses.
Cancer research 2006;66(10):5461-8.
2006: Ayyoub Maha; Souleimanian Naira E; Godefroy Emmanuelle; Scotto Luigi; Hesdorffer Charles S; Old Lloyd J; Valmori Danila
A phenotype based approach for the immune monitoring of NY-ESO-1-specific CD4+ T cell responses in cancer patients.
Clinical immunology (Orlando, Fla.) 2006;118(2-3):188-94.
2006: Valmori Danila; Qian Feng; Ayyoub Maha; Renner Christoph; Merlo Andrea; Gnjatic Sacha; Stockert Elisabeth; Driscoll Deborah; Lele Shashikant; Old Lloyd J; Odunsi Kunle
Expression of synovial sarcoma X (SSX) antigens in epithelial ovarian cancer and identification of SSX-4 epitopes recognized by CD4+ T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):398-404.
2005: Valmori Danila; Souleimanian Naira E; Hesdorffer Charles S; Old Lloyd J; Ayyoub Maha
Quantitative and qualitative assessment of circulating NY-ESO-1 specific CD4+ T cells in cancer-free individuals.
Clinical immunology (Orlando, Fla.) 2005;117(2):161-7.
2005: Valmori Danila; Souleimanian Naira E; Hesdorffer Charles S; Ritter Gerd; Old Lloyd J; Ayyoub Maha
Identification of B cell epitopes recognized by antibodies specific for the tumor antigen NY-ESO-1 in cancer patients with spontaneous immune responses.
Clinical immunology (Orlando, Fla.) 2005;117(1):24-30.
2005: Valmori Danila; Merlo Andrea; Souleimanian Naira E; Hesdorffer Charles S; Ayyoub Maha
A peripheral circulating compartment of natural naive CD4 Tregs.
The Journal of clinical investigation 2005;115(7):1953-62.
2005: Le Gal Frédérique-Anne; Ayyoub Maha; Dutoit Valérie; Widmer Valérie; Jäger Elke; Cerottini Jean-Charles; Dietrich Pierre-Yves; Valmori Danila
Distinct structural TCR repertoires in naturally occurring versus vaccine-induced CD8+ T-cell responses to the tumor-specific antigen NY-ESO-1.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2005;28(3):252-7.
2005: Ayyoub Maha; Merlo Andrea; Hesdorffer Charles S; Rimoldi Donata; Speiser Daniel; Cerottini Jean-Charles; Chen Yao-Tseng; Old Lloyd J; Stevanovic Stefan; Valmori Danila
CD4+ T cell responses to SSX-4 in melanoma patients.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):5092-9.
2005: Ayyoub Maha; Merlo Andrea; Hesdorffer Charles S; Speiser Daniel; Rimoldi Donata; Cerottini Jean-Charles; Ritter Gerd; Chen Yao-Tseng; Old Lloyd J; Stevanovic Stefan; Valmori Danila
Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2.
Clinical immunology (Orlando, Fla.) 2005;114(1):70-8.
2005: Michielin Olivier; Blanchet Jean-Sebastien; Fagerberg Theres; Valmori Danila; Rubio-Godoy Verena; Speiser Daniel; Ayyoub Maha; Alves Pedro; Luescher Immanuel; Gairin Jean-Edouard; Cerottini Jean-Charles; Romero Pedro
Tinkering with nature: the tale of optimizing peptide based cancer vaccines.
Cancer treatment and research 2005;123():267-91.
2004: Valmori Danila; Ayyoub Maha
Using modified antigenic sequences to develop cancer vaccines: are we losing the focus?
PLoS medicine 2004;1(2):e26.
2004: Chapatte Laurence; Servis Catherine; Valmori Danila; Burlet-Schiltz Odile; Dayer Johanna; Monsarrat Bernard; Romero Pedro; Lévy Frédéric
Final antigenic Melan-A peptides produced directly by the proteasomes are preferentially selected for presentation by HLA-A*0201 in melanoma cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6033-40.
2004: Matsuo Mitsutoshi; Nagata Yasuhiro; Sato Eiichi; Atanackovic Djordje; Valmori Danila; Chen Yao-Tseng; Ritter Gerd; Mellman Ira; Old Lloyd J; Gnjatic Sacha
IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14467-72.
2004: Ayyoub Maha; Taub Robert N; Keohan Mary-Louise; Hesdorffer Mary; Metthez Genevieve; Memeo Lorenzo; Mansukhani Mahesh; Hibshoosh Hanina; Hesdorffer Charles S; Valmori Danila
The frequent expression of cancer/testis antigens provides opportunities for immunotherapeutic targeting of sarcoma.
Cancer immunity : a journal of the Academy of Cancer Immunology 2004;4():7.
2004: Ayyoub Maha; Hesdorffer Charles S; Metthez Genevieve; Stevanovic Stefan; Ritter Gerd; Chen Yao-Tseng; Old Lloyd J; Speiser Daniel; Cerottini Jean-Charles; Valmori Danila
Identification of an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7206-11.
2004: Ayyoub Maha; Hesdorffer Charles S; Montes Monica; Merlo Andrea; Speiser Daniel; Rimoldi Donata; Cerottini Jean-Charles; Ritter Gerd; Scanlan Matthew; Old Lloyd J; Valmori Danila
An immunodominant SSX-2-derived epitope recognized by CD4+ T cells in association with HLA-DR.
The Journal of clinical investigation 2004;113(8):1225-33.
2004: Nino-Vasquez J Javier; Allicotti Gina; Borras Eva; Wilson Darcy B; Valmori Danila; Simon Richard; Martin Roland; Pinilla Clemencia
A powerful combination: the use of positional scanning libraries and biometrical analysis to identify cross-reactive T cell epitopes.
Molecular immunology 2004;40(14-15):1063-74.
2003: Valmori Danila; Dutoit Valérie; Ayyoub Maha; Rimoldi Donata; Guillaume Philippe; Liénard Danielle; Lejeune Ferdy; Cerottini Jean-Charles; Romero Pedro; Speiser Daniel E
Simultaneous CD8+ T cell responses to multiple tumor antigen epitopes in a multipeptide melanoma vaccine.
Cancer immunity : a journal of the Academy of Cancer Immunology 2003;3():15.
2003: Zhao Yingdong; Pinilla Clemencia; Valmori Danila; Martin Roland; Simon Richard
Application of support vector machines for T-cell epitopes prediction.
Bioinformatics (Oxford, England) 2003;19(15):1978-84.
2003: Ayyoub Maha; Brehm Michelle; Metthez Geneviève; Talbot Susan; Dutoit Valerie; Taub Robert N; Keohan Mary-Louise; Gure Ali O; Chen Yao-Tseng; Williamson Barbara; Jungbluth Achim A; Old Lloyd J; Hesdorffer Charles S; Valmori Danila
SSX antigens as tumor vaccine targets in human sarcoma.
Cancer immunity : a journal of the Academy of Cancer Immunology 2003;3():13.
2003: Ayyoub Maha; Rimoldi Donata; Guillaume Philippe; Romero Pedro; Cerottini Jean-Charles; Valmori Danila; Speiser Daniel
Tumor-reactive, SSX-2-specific CD8+ T cells are selectively expanded during immune responses to antigen-expressing tumors in melanoma patients.
Cancer research 2003;63(17):5601-6.
2003: Valmori Danila; Ayyoub Maha; Hesdorffer Charles S; Keilholz Ulrich; Scheibenbogen Carmen
A monoclonal melanoma-specific T-cell population phenotypically indistinguishable from CD3+ LGL-leukemia.
Blood 2003;101(11):4643-4.
2003: Dutoit Valérie; Guillaume Philippe; Ayyoub Maha; Hesdorffer Charles S; Luescher Immanuel F; Valmori Danila
Decreased binding of peptides-MHC class I (pMHC) multimeric complexes to CD8 affects their binding avidity for the TCR but does not significantly impact on pMHC/TCR dissociation rate.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5110-7.
2003: Dietrich Pierre-Yves; Le Gal Frédérique-Anne; Dutoit Valérie; Pittet Mikäel J; Trautman Lydie; Zippelius Alfred; Cognet Isabelle; Widmer Valérie; Walker Paul R; Michielin Olivier; Guillaume Philippe; Connerotte Thierry; Jotereau Francine; Coulie Pierre G; Romero Pedro; Cerottini Jean-Charles; Bonneville Marc; Valmori Danila
Prevalent role of TCR alpha-chain in the selection of the preimmune repertoire specific for a human tumor-associated self-antigen.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5103-9.
2003: Ayyoub Maha; Zippelius Alfred; Pittet Mikaël J; Rimoldi Donata; Valmori Danila; Cerottini Jean-Charles; Romero Pedro; Lejeune Ferdy; Liénard Danielle; Speiser Daniel E
Activation of human melanoma reactive CD8+ T cells by vaccination with an immunogenic peptide analog derived from Melan-A/melanoma antigen recognized by T cells-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):669-77.
2003: Gnjatic Sacha; Atanackovic Djordje; Matsuo Mitsutoshi; Jäger Elke; Lee Sang Yull; Valmori Danila; Chen Yao-Tseng; Ritter Gerd; Knuth Alexander; Old Lloyd J
Cross-presentation of HLA class I epitopes from exogenous NY-ESO-1 polypeptides by nonprofessional APCs.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1191-6.
2002: Dutoit Valérie; Taub Robert N; Papadopoulos Kyriakos P; Talbot Susan; Keohan Mary-Louise; Brehm Michelle; Gnjatic Sacha; Harris Paul E; Bisikirska Brygida; Guillaume Philippe; Cerottini Jean-Charles; Hesdorffer Charles S; Old Lloyd J; Valmori Danila
Multiepitope CD8(+) T cell response to a NY-ESO-1 peptide vaccine results in imprecise tumor targeting.
The Journal of clinical investigation 2002;110(12):1813-22.
2002: Romero Pedro; Pittet Mikael; Dutoit Valerie; Zippelius Alfred; Liénard Danielle; Lejeune Ferdy; Guillaume Philippe; Rimoldi Donata; Valmori Danila; Speiser Daniel E; Cerottini Jean-Charles
Therapeutic cancer vaccines based on molecularly defined human tumor antigens.
Vaccine 2002;20 Suppl 4():A2-7.
2002: Dutoit Valérie; Guillaume Philippe; Cerottini Jean-Charles; Romero Pedro; Valmori Danila
Dissecting TCR-MHC/peptide complex interactions with A2/peptide multimers incorporating tumor antigen peptide variants: crucial role of interaction kinetics on functional outcomes.
European journal of immunology 2002;32(11):3285-93.
2002: Rubio-Godoy Verena; Dutoit Valérie; Zhao Yingdong; Simon Richard; Guillaume Philippe; Houghten Richard; Romero Pedro; Cerottini Jean-Charles; Pinilla Clemencia; Valmori Danila
Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5696-707.
2002: Romero Pedro; Valmori Danila; Pittet Mikael J; Zippelius Alfred; Rimoldi Donata; Lévy Frederic; Dutoit Valérie; Ayyoub Maha; Rubio-Godoy Verena; Michielin Olivier; Guillaume Philippe; Batard Pascal; Luescher Immanuel F; Lejeune Ferdy; Liénard Danielle; Rufer Nathalie; Dietrich Pierre-Yves; Speiser Daniel E; Cerottini Jean-Charles
Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.
Immunological reviews 2002;188():81-96.
2002: Borràs Eva; Martin Roland; Judkowski Valeria; Shukaliak Jacqueline; Zhao Yingdong; Rubio-Godoy Verena; Valmori Danila; Wilson Darcy; Simon Richard; Houghten Richard; Pinilla Clemencia
Findings on T cell specificity revealed by synthetic combinatorial libraries.
Journal of immunological methods 2002;267(1):79-97.
2002: Rubio-Godoy Verena; Ayyoub Maha; Dutoit Valerie; Servis Catherine; Schink Amy; Rimoldi Donata; Romero Pedro; Cerottini Jean-Charles; Simon Richard; Zhao Yindong; Houghten Richard A; Pinilla Clemencia; Valmori Danila
Combinatorial peptide library-based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity.
European journal of immunology 2002;32(8):2292-9.
2002: Nagata Yasuhiro; Ono Satoru; Matsuo Mitsutoshi; Gnjatic Sacha; Valmori Danila; Ritter Gerd; Garrett Wendy; Old Lloyd J; Mellman Ira
Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10629-34.
2002: Dutoit Valérie; Guillaume Philippe; Romero Pedro; Cerottini Jean-Charles; Valmori Danila
Functional analysis of HLA-A*0201/Melan-A peptide multimer+ CD8+ T cells isolated from an HLA-A*0201- donor: exploring tumor antigen allorestricted recognition.
Cancer immunity : a journal of the Academy of Cancer Immunology 2002;2():7.
2002: Dutoit Valérie; Rubio-Godoy Verena; Pittet Mikäel J; Zippelius Alfred; Dietrich Pierre-Yves; Legal Frédérique Anne; Guillaume Philippe; Romero Pedro; Cerottini Jean-Charles; Houghten Richard A; Pinilla Clemencia; Valmori Danila
Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans.
The Journal of experimental medicine 2002;196(2):207-16.
2002: Pittet Mikaël J; Zippelius Alfred; Valmori Danila; Speiser Daniel E; Cerottini Jean-Charles; Romero Pedro
Melan-A/MART-1-specific CD8 T cells: from thymus to tumor.
Trends in immunology 2002;23(7):325-8.
2002: Valmori Danila; Dutoit Valerie; Schnuriger Valerie; Quiquerez Anne-Lise; Pittet Mikaël J; Guillaume Philippe; Rubio-Godoy Verena; Walker Paul R; Rimoldi Donata; Liénard Danielle; Cerottini Jean-Charles; Romero Pedro; Dietrich Pierre-Yves
Vaccination with a Melan-A peptide selects an oligoclonal T cell population with increased functional avidity and tumor reactivity.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4231-40.
2002: Rubio-Godoy Verena; Pinilla Clemencia; Dutoit Valerie; Borras Eva; Simon Richard; Zhao Yingdong; Cerottini Jean-Charles; Romero Pedro; Houghten Richard; Valmori Danila
Toward synthetic combinatorial peptide libraries in positional scanning format (PS-SCL)-based identification of CD8+ Tumor-reactive T-Cell Ligands: a comparative analysis of PS-SCL recognition by a single tumor-reactive CD8+ cytolytic T-lymphocyte clone.
Cancer research 2002;62(7):2058-63.
2002: Arévalo-Herrera Myriam; Valencia Anais Zully; Vergara Juana; Bonelo Anilza; Fleischhauer Katharina; González John Mario; Restrepo Juan Carlos; López José Alejandro; Valmori Danila; Corradin Giampietro; Herrera Sócrates
Identification of HLA-A2 restricted CD8(+) T-lymphocyte responses to Plasmodium vivax circumsporozoite protein in individuals naturally exposed to malaria.
Parasite immunology 2002;24(3):161-9.
2002: Valmori Danila; Scheibenbogen Carmen; Dutoit Valerie; Nagorsen Dirk; Asemissen Anne Marie; Rubio-Godoy Verena; Rimoldi Donata; Guillaume Philippe; Romero Pedro; Schadendorf Dirk; Lipp Martin; Dietrich Pierre-Yves; Thiel Eckhard; Cerottini Jean-Charles; Liénard Danielle; Keilholz Ulrich
Circulating Tumor-reactive CD8(+) T cells in melanoma patients contain a CD45RA(+)CCR7(-) effector subset exerting ex vivo tumor-specific cytolytic activity.
Cancer research 2002;62(6):1743-50.
2002: Zippelius Alfred; Pittet Mikaël J; Batard Pascal; Rufer Nathalie; de Smedt Magda; Guillaume Philippe; Ellefsen Kim; Valmori Danila; Liénard Danielle; Plum Jean; MacDonald H Robson; Speiser Daniel E; Cerottini Jean-Charles; Romero Pedro
Thymic selection generates a large T cell pool recognizing a self-peptide in humans.
The Journal of experimental medicine 2002;195(4):485-94.
2002: Ayyoub Maha; Stevanovic Stefan; Sahin Ugur; Guillaume Philippe; Servis Catherine; Rimoldi Donata; Valmori Danila; Romero Pedro; Cerottini Jean-Charles; Rammensee Hans-Georg; Pfreundschuh Michael; Speiser Daniel; Lévy Frédéric
Proteasome-assisted identification of a SSX-2-derived epitope recognized by tumor-reactive CTL infiltrating metastatic melanoma.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1717-22.
2002: Dutoit Valérie; Rubio-Godoy Verena; Doucey Marie-Agnès; Batard Pascal; Liénard Danielle; Rimoldi Donata; Speiser Daniel; Guillaume Philippe; Cerottini Jean-Charles; Romero Pedro; Valmori Danila
Functional avidity of tumor antigen-specific CTL recognition directly correlates with the stability of MHC/peptide multimer binding to TCR.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1167-71.
2001: Puente Navazo M D; Valmori D; Rüegg C
The alternatively spliced domain TnFnIII A1A2 of the extracellular matrix protein tenascin-C suppresses activation-induced T lymphocyte proliferation and cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6431-40.
2001: Speiser D E; Colonna M; Ayyoub M; Cella M; Pittet M J; Batard P; Valmori D; Guillaume P; Liénard D; Cerottini J C; Romero P
The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6165-70.
2001: Rimoldi D; Muehlethaler K; Salvi S; Valmori D; Romero P; Cerottini J C; Levy F
Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope.
The Journal of biological chemistry 2001;276(46):43189-96.
2001: Ayyoub M; Migliaccio M; Guillaume P; Liénard D; Cerottini J C; Romero P; Lévy F; Speiser D E; Valmori D
Lack of tumor recognition by hTERT peptide 540-548-specific CD8(+) T cells from melanoma patients reveals inefficient antigen processing.
European journal of immunology 2001;31(9):2642-51.
2001: Rubio-Godoy V; Dutoit V; Rimoldi D; Lienard D; Lejeune F; Speiser D; Guillaume P; Cerottini J C; Romero P; Valmori D
Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10302-7.
2001: Dutoit V; Rubio-Godoy V; Dietrich P Y; Quiqueres A L; Schnuriger V; Rimoldi D; Liénard D; Speiser D; Guillaume P; Batard P; Cerottini J C; Romero P; Valmori D
Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activity.
Cancer research 2001;61(15):5850-6.
2001: Pinilla C; Rubio-Godoy V; Dutoit V; Guillaume P; Simon R; Zhao Y; Houghten R A; Cerottini J C; Romero P; Valmori D
Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes.
Cancer research 2001;61(13):5153-60.
2001: Pittet M J; Zippelius A; Speiser D E; Assenmacher M; Guillaume P; Valmori D; Liénard D; Lejeune F; Cerottini J C; Romero P
Ex vivo IFN-gamma secretion by circulating CD8 T lymphocytes: implications of a novel approach for T cell monitoring in infectious and malignant diseases.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7634-40.
2001: Pittet M J; Speiser D E; Liénard D; Valmori D; Guillaume P; Dutoit V; Rimoldi D; Lejeune F; Cerottini J C; Romero P
Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3 Suppl):796s-803s.
2001: Romero P; Dutoit V; Rubio-Godoy V; Liénard D; Speiser D; Guillaume P; Servis K; Rimoldi D; Cerottini J C; Valmori D
CD8+ T-cell response to NY-ESO-1: relative antigenicity and in vitro immunogenicity of natural and analogue sequences.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3 Suppl):766s-772s.
2001: Dietrich P Y; Walker P R; Quiquerez A L; Perrin G; Dutoit V; Liénard D; Guillaume P; Cerottini J C; Romero P; Valmori D
Melanoma patients respond to a cytotoxic T lymphocyte-defined self-peptide with diverse and nonoverlapping T-cell receptor repertoires.
Cancer research 2001;61(5):2047-54.
2001: Speiser D E; Migliaccio M; Pittet M J; Valmori D; Liénard D; Lejeune F; Reichenbach P; Guillaume P; Lüscher I; Cerottini J C; Romero P
Human CD8(+) T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells.
European journal of immunology 2001;31(2):459-66.
2001: Valmori D; Dutoit V; Rubio-Godoy V; Chambaz C; Liénard D; Guillaume P; Romero P; Cerottini J C; Rimoldi D
Frequent cytolytic T-cell responses to peptide MAGE-A10(254-262) in melanoma.
Cancer research 2001;61(2):509-12.
2000: Rimoldi D; Rubio-Godoy V; Dutoit V; Lienard D; Salvi S; Guillaume P; Speiser D; Stockert E; Spagnoli G; Servis C; Cerottini J C; Lejeune F; Romero P; Valmori D
Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7253-61.
2000: Bonelo A; Valmori D; Triponez F; Tiercy J M; Mentha G; Oberholzer J; Champagne P; Romero J F; Esposito F; Nebié I; Barbey C; Romero P; Herrera S; Corradin G; López J A
Generation and characterization of malaria-specific human CD8(+) lymphocyte clones: effect of natural polymorphism on T cell recognition and endogenous cognate antigen presentationby liver cells.
European journal of immunology 2000;30(11):3079-88.
2000: Migliaccio M; Amacker M; Just T; Reichenbach P; Valmori D; Cerottini J C; Romero P; Nabholz M
Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4978-84.
2000: González J M; Peter K; Esposito F; Nebié I; Tiercy J M; Bonelo A; Arévalo-Herrera M; Valmori D; Romero P; Herrera S; Corradin G; López J A
HLA-A*0201 restricted CD8+ T-lymphocyte responses to malaria: identification of new Plasmodium falciparum epitopes by IFN-gamma ELISPOT.
Parasite immunology 2000;22(10):501-14.
2000: Valmori D; Dutoit V; Liénard D; Rimoldi D; Pittet M J; Champagne P; Ellefsen K; Sahin U; Speiser D; Lejeune F; Cerottini J C; Romero P
Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.
Cancer research 2000;60(16):4499-506.
2000: Valmori D; Dutoit V; Liénard D; Lejeune F; Speiser D; Rimoldi D; Cerundolo V; Dietrich P Y; Cerottini J C; Romero P
Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):533-8.
2000: Pittet M J; Speiser D E; Valmori D; Cerottini J C; Romero P
Cutting edge: cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1148-52.
2000: Valmori D; Lévy F; Miconnet I; Zajac P; Spagnoli G C; Rimoldi D; Liénard D; Cerundolo V; Cerottini J C; Romero P
Induction of potent antitumor CTL responses by recombinant vaccinia encoding a melan-A peptide analogue.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):1125-31.
1999: Valmori D; Fonteneau J F; Valitutti S; Gervois N; Dunbar R; Liénard D; Rimoldi D; Cerundolo V; Jotereau F; Cerottini J C; Speiser D E; Romero P
Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues.
International immunology 1999;11(12):1971-80.
1999: Speiser D E; Pittet M J; Valmori D; Dunbar R; Rimoldi D; Liénard D; MacDonald H R; Cerottini J C; Cerundolo V; Romero P
In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.
The Journal of experimental medicine 1999;190(6):775-82.
1999: Pittet M J; Valmori D; Dunbar P R; Speiser D E; Liénard D; Lejeune F; Fleischhauer K; Cerundolo V; Cerottini J C; Romero P
High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals.
The Journal of experimental medicine 1999;190(5):705-15.
1999: Valmori D; Pittet M J; Vonarbourg C; Rimoldi D; Liénard D; Speiser D; Dunbar R; Cerundolo V; Cerottini J C; Romero P
Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.
Cancer research 1999;59(16):4050-5.
1999: Speiser D E; Valmori D; Rimoldi D; Pittet M J; Liénard D; Cerundolo V; MacDonald H R; Cerottini J C; Romero P
CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients.
European journal of immunology 1999;29(6):1990-9.
1999: Schneider P; MacKay F; Steiner V; Hofmann K; Bodmer J L; Holler N; Ambrose C; Lawton P; Bixler S; Acha-Orbea H; Valmori D; Romero P; Werner-Favre C; Zubler R H; Browning J L; Tschopp J
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
The Journal of experimental medicine 1999;189(11):1747-56.
1999: Valmori D; Pittet M J; Rimoldi D; Liénard D; Dunbar R; Cerundolo V; Lejeune F; Cerottini J C; Romero P
An antigen-targeted approach to adoptive transfer therapy of cancer.
Cancer research 1999;59(9):2167-73.
1999: Men Y; Miconnet I; Valmori D; Rimoldi D; Cerottini J C; Romero P
Assessment of immunogenicity of human Melan-A peptide analogues in HLA-A*0201/Kb transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3566-73.
1999: Valmori D; Gileadi U; Servis C; Dunbar P R; Cerottini J C; Romero P; Cerundolo V; Lévy F
Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3.
The Journal of experimental medicine 1999;189(6):895-906.
1998: Valmori D; Gervois N; Rimoldi D; Fonteneau J F; Bonelo A; Liénard D; Rivoltini L; Jotereau F; Cerottini J C; Romero P
Diversity of the fine specificity displayed by HLA-A*0201-restricted CTL specific for the immunodominant Melan-A/MART-1 antigenic peptide.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6956-62.
1998: Romero P; Dunbar P R; Valmori D; Pittet M; Ogg G S; Rimoldi D; Chen J L; Liénard D; Cerottini J C; Cerundolo V
Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes.
The Journal of experimental medicine 1998;188(9):1641-50.
1998: Fleischhauer K; Zino E; Arevalo-Herrera M; Herrera S; Valmori D; Cerottini J C; Benazzi E; Bordignon C; Romero P
Differential expression of HLA-A*02 subtypes in Colombian Blacks and Mestizos.
Tissue antigens 1998;51(2):204-9.
1998: Valmori D; Fonteneau J F; Lizana C M; Gervois N; Liénard D; Rimoldi D; Jongeneel V; Jotereau F; Cerottini J C; Romero P
Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1750-8.
1998: Cerottini J C; Valmori D; Rimoldi D; Romero P
Human tumor immunotherapy. New opportunities as well as new challenges.
Advances in experimental medicine and biology 1998;451():247-50.
1997: Romero P; Gervois N; Schneider J; Escobar P; Valmori D; Pannetier C; Steinle A; Wolfel T; Lienard D; Brichard V; van Pel A; Jotereau F; Cerottini J C
Cytolytic T lymphocyte recognition of the immunodominant HLA-A*0201-restricted Melan-A/MART-1 antigenic peptide in melanoma.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2366-74.
1997: Valmori D; Liénard D; Waanders G; Rimoldi D; Cerottini J C; Romero P
Analysis of MAGE-3-specific cytolytic T lymphocytes in human leukocyte antigen-A2 melanoma patients.
Cancer research 1997;57(4):735-41.
1996: Eberl G; Kessler B; Eberl L P; Brunda M J; Valmori D; Corradin G
Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12.
European journal of immunology 1996;26(11):2709-16.
1995: Renggli J; Valmori D; Romero J F; Eberl G; Romero P; Betschart B; Corradin G
CD8+ T-cell protective immunity induced by immunization with Plasmodium berghei CS protein-derived synthetic peptides: evidence that localization of peptide-specific CTLs is crucial for protection against malaria.
Immunology letters 1995;46(1-2):199-205.
1995: Blum-Tirouvanziam U; Servis C; Habluetzel A; Valmori D; Men Y; Esposito F; Del Nero L; Holmes N; Fasel N; Corradin G
Localization of HLA-A2.1-restricted T cell epitopes in the circumsporozoite protein of Plasmodium falciparum.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):3922-31.
1994: Blum-Tirouvanziam U; Beghdadi-Rais C; Roggero M A; Valmori D; Bertholet S; Bron C; Fasel N; Corradin G
Elicitation of specific cytotoxic T cells by immunization with malaria soluble synthetic polypeptides.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4134-41.
1994: Valmori D; Romero J F; Men Y; Maryanski J L; Romero P; Corradin G
Induction of a cytotoxic T cell response by co-injection of a T helper peptide and a cytotoxic T lymphocyte peptide in incomplete Freund's adjuvant (IFA): further enhancement by pre-injection of IFA alone.
European journal of immunology 1994;24(6):1458-62.
1994: Valmori D; Sabbatini A; Lanzavecchia A; Corradin G; Matricardi P M
Functional analysis of two tetanus toxin universal T cell epitopes in their interaction with DR1101 and DR1104 alleles.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2921-9.
1994: Yu Z; Healy F; Valmori D; Escobar P; Corradin G; Mach J P
Peptide-antibody conjugates for tumour therapy: a MHC-class-II-restricted tetanus toxin peptide coupled to an anti-Ig light chain antibody can induce cytotoxic lysis of a human B-cell lymphoma by specific CD4 T cells.
International journal of cancer. Journal international du cancer 1994;56(2):244-8.
1993: Grillot D; Valmori D; Lambert P H; Corradin G; Del Giudice G
Presentation of T-cell epitopes assembled as multiple-antigen peptides to murine and human T lymphocytes.
Infection and immunity 1993;61(7):3064-7.
1992: Widmann C; Romero P; Maryanski J L; Corradin G; Valmori D
T helper epitopes enhance the cytotoxic response of mice immunized with MHC class I-restricted malaria peptides.
Journal of immunological methods 1992;155(1):95-9.
1992: Valmori D; Pessi A; Bianchi E; Corradin G
Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):717-21.
1991: Pessi A; Valmori D; Migliorini P; Tougne C; Bianchi E; Lambert P H; Corradin G; Del Giudice G
Lack of H-2 restriction of the Plasmodium falciparum (NANP) sequence as multiple antigen peptide.
European journal of immunology 1991;21(9):2273-6.

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