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Spyros Vamvakas

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Angela Mally; Cheryl Lyn Walker; Jeffrey I Everitt; Wolfgang Dekant; Spyros Vamvakas
Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
Werner K Lutz; Spyros Vamvakas; Annette Kopp-Schneider; Josef Schlatter; Helga Stopper
Deviation from additivity in mixture toxicity: relevance of nonlinear dose-response relationships and cell line differences in genotoxicity assays with combinations of chemical mutagens and gamma-radiation.
Spyros Vamvakas; Thomas Brüning; Hermann M Bolt; D Henschler; K Ulm
Renal cell cancer correlated with occupational exposure to trichloroethene.

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2006: Angela Mally; Cheryl Lyn Walker; Jeffrey I Everitt; Wolfgang Dekant; Spyros Vamvakas
Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
Toxicology 2006;224(1-2):108-18.
2002: Werner K Lutz; Spyros Vamvakas; Annette Kopp-Schneider; Josef Schlatter; Helga Stopper
Deviation from additivity in mixture toxicity: relevance of nonlinear dose-response relationships and cell line differences in genotoxicity assays with combinations of chemical mutagens and gamma-radiation.
Environmental health perspectives 2002;110 Suppl 6():915-8.
2000: Spyros Vamvakas; Thomas Brüning; Hermann M Bolt; D Henschler; K Ulm
Renal cell cancer correlated with occupational exposure to trichloroethene.
Journal of cancer research and clinical oncology 2000;126(3):178-80.
2000: August Heidland; Udo Bahner; Spyros Vamvakas
Incidence and spectrum of dialysis-associated cancer in three continents.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2000;35(2):347-51; discussion 352-3.
1999: Helga Stopper; T Meysen; A Böckenförde; Udo Bahner; August Heidland; Spyros Vamvakas
Increased genomic damage in lymphocytes of patients before and after long-term maintenance hemodialysis therapy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1999;34(3):433-7.
1999: EH Vock; Werner K Lutz; O Ilinskaya; Spyros Vamvakas
Discrimination between genotoxicity and cytotoxicity for the induction of DNA double-strand breaks in cells treated with aldehydes and diepoxides.
Mutation research 1999;441(1):85-93.
1998: EH Vock; Spyros Vamvakas; R Gahlmann; Werner K Lutz
Investigation of the induction of DNA double-strand breaks by methylenediphenyl-4-4'-diisocyanate in cultured human lung epithelial cells.
Toxicological sciences : an official journal of the Society of Toxicology 1998;46(1):83-9.
1998: Hans-Günter Neumann; Spyros Vamvakas; Heinz Walter Thielmann; HP Gelbke; Johannes G Filser; Ulrike Reuter; H Greim; H Kappus; KH Norpoth; P Wardenbach; HE Wichmann
Changes in the classification of carcinogenic chemicals in the work area. Section III of the German List of MAK and BAT Values.
International archives of occupational and environmental health 1998;71(8):566-74.
1998: Katarína Sebeková; Reinhard Schinzel; H Ling; Andreas Simm; G Xiang; M Gekle; Gerald Münch; Spyros Vamvakas; August Heidland
Advanced glycated albumin impairs protein degradation in the kidney proximal tubules cell line LLC-PK1.
Cellular and molecular biology (Noisy-le-Grand, France) 1998;44(7):1051-60.
1998: Spyros Vamvakas; Markus Teschner; Udo Bahner; August Heidland
Alcohol abuse: potential role in electrolyte disturbances and kidney diseases.
Clinical nephrology 1998;49(4):205-13.
1998: Werner K Lutz; T Fekete; Spyros Vamvakas
Position- and base pair-specific comparison of p53 mutation spectra in human tumors: elucidation of relationships between organs for cancer etiology.
Environmental health perspectives 1998;106(4):207-11.
1998: EH Vock; Werner K Lutz; P Hormes; H D Hoffmann; Spyros Vamvakas
Discrimination between genotoxicity and cytotoxicity in the induction of DNA double-strand breaks in cells treated with etoposide, melphalan, cisplatin, potassium cyanide, Triton X-100, and gamma-irradiation.
Mutation research 1998;413(1):83-94.
1998: Thomas Brüning; Spyros Vamvakas; V Makropoulos; G Birner
Acute intoxication with trichloroethene: clinical symptoms, toxicokinetics, metabolism, and development of biochemical parameters for renal damage.
Toxicological sciences : an official journal of the Society of Toxicology 1998;41(2):157-65.
1998: H Richter; Spyros Vamvakas
S-(1,2-dichlorovinyl)-L-cysteine-induced dedifferentiation and p53 gene mutations in LLC-PK1 cells: a comparative investigation with S-(2-chloroethyl)cysteine, potassium bromate, cis-platinum and styrene oxide.
Toxicology letters 1998;94(2):145-57.
1998: Hans-Günter Neumann; Heinz Walter Thielmann; Johannes G Filser; HP Gelbke; H Greim; H Kappus; KH Norpoth; Ulrike Reuter; Spyros Vamvakas; P Wardenbach; HE Wichmann
Changes in the classification of carcinogenic chemicals in the work area. (Section III of the German List of MAK and BAT values).
Journal of cancer research and clinical oncology 1998;124(12):661-9.
1998: Spyros Vamvakas; Thomas Brüning; B Thomasson; Marga Lammert; A Baumüller; Hermann M Bolt; Wolfgang Dekant; G Birner; D Henschler; K Ulm
Renal cell cancer correlated with occupational exposure to trichloroethene.
Journal of cancer research and clinical oncology 1998;124(7):374-82.
1998: Spyros Vamvakas; Udo Bahner; August Heidland
Cancer in end-stage renal disease: potential factors involved -editorial-.
American journal of nephrology 1998;18(2):89-95.
1998: O Schenk; H Ling; Katarína Sebeková; Spyros Vamvakas; August Heidland
High-glucose media enhance the responsiveness of tubular cells to growth promoters: effect on lysosomal cathepsins and protein degradation.
Mineral and electrolyte metabolism 1998;24(4):254-60.
1997: Hans-Günter Neumann; Heinz Walter Thielmann; Johannes G Filser; HP Gelbke; H Greim; H Kappus; KH Norpoth; Ulrike Reuter; Spyros Vamvakas; P Wardenbach; HE Wichmann
Proposed changes in the classification of carcinogenic chemicals in the work area.
Regulatory toxicology and pharmacology : RTP 1997;26(3):288-95.
1997: August Heidland; Spyros Vamvakas; Udo Bahner; L Paczek
Cancer in endstage renal failure: potential pathogenic factors.
Polskie Archiwum Medycyny Wewnętrznej 1997;98(10):319-26.
1997: Andreas Simm; Gerald Münch; F Seif; O Schenk; August Heidland; H Richter; Spyros Vamvakas; Reinhard Schinzel
Advanced glycation endproducts stimulate the MAP-kinase pathway in tubulus cell line LLC-PK1.
FEBS letters 1997;410(2-3):481-4.
1997: Spyros Vamvakas; Udo Bahner; August Heidland
[Increased cancer incidence in terminal kidney failure: potential pathogenetic mechanisms].
Schweizerische medizinische Wochenschrift 1997;127(14):597-604.
1997: Spyros Vamvakas; EH Vock; Werner K Lutz
On the role of DNA double-strand breaks in toxicity and carcinogenesis.
Critical reviews in toxicology 1997;27(2):155-74.
1997: Spyros Vamvakas; H Richter; D Bittner
Poly(ADP-ribosyl)ation and nuclear matrix/intermediate filament proteins in renal carcinogenesis.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1997;143():195-208.
1996: Wolfgang Dekant; Spyros Vamvakas
Biotransformation and membrane transport in nephrotoxicity.
Critical reviews in toxicology 1996;26(3):309-34.
1996: Spyros Vamvakas; H Richter; D Bittner
Induction of dedifferentiated clones of LLC-PK1 cells upon long-term exposure to dichlorovinylcysteine.
Toxicology 1996;106(1-3):65-74.
1996: O Ilinskaja; Spyros Vamvakas
Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine.
Archives of toxicology 1996;70(3-4):224-9.
1996: H Ling; Spyros Vamvakas; Michael Gekle; Liliana Schaefer; Markus Teschner; Roland M Schaefer; August Heidland
Role of lysosomal cathepsin activities in cell hypertrophy induced by NH4Cl in cultured renal proximal tubule cells.
Journal of the American Society of Nephrology : JASN 1996;7(1):73-80.
1996: August Heidland; H Ling; Spyros Vamvakas; L Paczek
Impaired proteolytic activity as a potential cause of progressive renal disease.
Mineral and electrolyte metabolism 1996;22(1-3):157-61.
1995: H Ling; Spyros Vamvakas; GL Busch; J Dämmrich; Lothar Schramm; Florian Lang; August Heidland
Suppressing role of transforming growth factor-beta 1 on cathepsin activity in cultured kidney tubule cells.
The American journal of physiology 1995;269(6 Pt 2):F911-7.
1995: H Ling; Spyros Vamvakas; Liliana Schaefer; Lothar Schramm; L Paczek; J Daemmrich; Roland M Schaefer; August Heidland
Dose-dependent stimulation/inhibition effects of cyclosporin A on lysosomal cathepsin activities in cultured proximal tubule cells.
Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie 1995;195(6):355-64.
1995: H Ling; Spyros Vamvakas; Liliana Schaefer; Hans-Joachim Schnittler; Roland M Schaefer; August Heidland
Angiotensin-II-induced cell hypertrophy: potential role of impaired proteolytic activity in cultured LLC-PK1 cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10(8):1305-12.
1995: H Ling; Spyros Vamvakas; Liliana Schaefer; Roland M Schaefer; Markus Teschner; Lothar Schramm; August Heidland
Insulin-like growth factor I induced reduction in cysteine proteinase activity in freshly isolated proximal tubule cells of the rat.
Nephron 1995;69(1):83-5.
1995: D Henschler; Spyros Vamvakas; Marga Lammert; Wolfgang Dekant; B Kraus; B Thomas; K Ulm
Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene.
Archives of toxicology 1995;69(5):291-9.
1994: J McLaren; Teni Boulikas; Spyros Vamvakas
Induction of poly(ADP-ribosyl)ation in the kidney after in vivo application of renal carcinogens.
Toxicology 1994;88(1-3):101-12.
1994: M B Finkelstein; Spyros Vamvakas; D Bittner; MW Anders
Structure-mutagenicity and structure-cytotoxicity studies on bromine-containing cysteine S-conjugates and related compounds.
Chemical research in toxicology 1994;7(2):157-63.
1994: Spyros Vamvakas; MW Anders
Bioconversion of prodrugs by conjugate-processing enzymes.
Advances in pharmacology (San Diego, Calif.) 1994;27():479-99.
1994: Wolfgang Dekant; Spyros Vamvakas; MW Anders
Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway.
Advances in pharmacology (San Diego, Calif.) 1994;27():115-62.
1993: A Mentzschel; Spyros Vamvakas; Wolfgang Dekant; D Henschler
DNA adduct formation in Salmonella typhimurium, cultured liver cells and in Fischer 344 rats treated with o-tolyl phosphates and their metabolites.
Carcinogenesis 1993;14(10):2039-43.
1993: Wolfgang Dekant; Spyros Vamvakas
Glutathione-dependent bioactivation of xenobiotics.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(8):873-87.
1993: Spyros Vamvakas; D Bittner; U Köster
Enhanced expression of the protooncogenes c-myc and c-fos in normal and malignant renal growth.
Toxicology letters 1993;67(1-3):161-72.
1993: G Birner; Spyros Vamvakas; Wolfgang Dekant; D Henschler
Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure.
Environmental health perspectives 1993;99():281-4.
1993: Spyros Vamvakas; U Köster
The nephrotoxin dichlorovinylcysteine induces expression of the protooncogenes c-fos and c-myc in LLC-PK1 cells--a comparative investigation with growth factors and 12-O-tetradecanoylphorbolacetate.
Cell biology and toxicology 1993;9(1):1-13.
1992: Spyros Vamvakas; D Bittner; Wolfgang Dekant; MW Anders
Events that precede and that follow S-(1,2-dichlorovinyl)-L-cysteine-induced release of mitochondrial Ca2+ and their association with cytotoxicity to renal cells.
Biochemical pharmacology 1992;44(6):1131-8.
1992: MW Anders; W Dekant; Spyros Vamvakas
Glutathione-dependent toxicity.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(9-10):1135-45.
1992: Spyros Vamvakas; D Bittner; M Koob; S Glück; Wolfgang Dekant
Glutathione depletion, lipid peroxidation, DNA double-strand breaks and the cytotoxicity of 2-bromo-3-(N-acetylcystein-S-yl)hydroquinone in rat renal cortical cells.
Chemico-biological interactions 1992;83(2):183-99.
1992: M Hashmi; Spyros Vamvakas; MW Anders
Bioactivation mechanism of S-(3-oxopropyl)-N-acetyl-L-cysteine, the mercapturic acid of acrolein.
Chemical research in toxicology 1992;5(3):360-5.
1992: S B Park; J D Osterloh; Spyros Vamvakas; M Hashmi; MW Anders; J R Cashman
Flavin-containing monooxygenase-dependent stereoselective S-oxygenation and cytotoxicity of cysteine S-conjugates and mercapturates.
Chemical research in toxicology 1992;5(2):193-201.
1992: Wolfgang Dekant; Spyros Vamvakas
Mechanisms of xenobiotic-induced renal carcinogenicity.
Advances in pharmacology (San Diego, Calif.) 1992;23():297-337.
1991: Y Gietl; Spyros Vamvakas; MW Anders
Intestinal absorption of S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(3):703-7.
1991: Spyros Vamvakas; MW Anders
Formation of reactive intermediates by phase II enzymes: glutathione-dependent bioactivation reactions.
Advances in experimental medicine and biology 1991;283():13-24.
1990: Spyros Vamvakas; Virendra K Sharma; Shey-Shing Sheu; MW Anders
Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates.
Molecular pharmacology 1990;38(4):455-61.
1990: Wolfgang Dekant; Spyros Vamvakas; M W Anders
Biosynthesis, bioactivation, and mutagenicity of S-conjugates.
Toxicology letters 1990;53(1-2):53-8.
1990: Spyros Vamvakas; M W Anders
Perturbation of calcium homeostasis as a link between acute cell injury and carcinogenesis in the kidney.
Toxicology letters 1990;53(1-2):115-20.
1990: Wolfgang Dekant; Spyros Vamvakas; M Koob; A Köchling; W Kanhai; D Müller; D Henschler
A mechanism of haloalkene-induced renal carcinogenesis.
Environmental health perspectives 1990;88():107-10.
1990: Wolfgang Dekant; Spyros Vamvakas; MW Anders
Bioactivation of hexachlorobutadiene by glutathione conjugation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1990;28(4):285-93.
1989: Spyros Vamvakas; E Kremling; Wolfgang Dekant
Metabolic activation of the nephrotoxic haloalkene 1,1,2-trichloro-3,3,3-trifluoro-1-propene by glutathione conjugation.
Biochemical pharmacology 1989;38(14):2297-304.
1989: Spyros Vamvakas; Wolfgang Dekant; D Henschler
Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine S-conjugates of haloalkenes and haloalkanes.
Mutation research 1989;222(4):329-35.
1989: Spyros Vamvakas; Wolfgang Dekant; MW Anders
Mutagenicity of benzyl S-haloalkyl and S-haloalkenyl sulfides in the Ames-test.
Biochemical pharmacology 1989;38(6):935-9.
1989: Spyros Vamvakas; Wolfgang Dekant; D Henschler
Genotoxicity of haloalkene and haloalkane glutathione S-conjugates in porcine kidney cells.
Toxicology in vitro : an international journal published in association with BIBRA 1989;3(2):151-6.
1989: Spyros Vamvakas; A Köchling; K Berthold; Wolfgang Dekant
Cytotoxicity of cysteine S-conjugates: structure-activity relationships.
Chemico-biological interactions 1989;71(1):79-90.
1989: Spyros Vamvakas; M Herkenhoff; Wolfgang Dekant; D Henschler
Mutagenicity of tetrachloroethene in the Ames test--metabolic activation by conjugation with glutathione.
Journal of biochemical toxicology 1989;4(1):21-7.
1989: Wolfgang Dekant; Spyros Vamvakas; MW Anders
Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase.
Drug metabolism reviews 1989;20(1):43-83.
1988: Spyros Vamvakas; Wolfgang Dekant; Dietmar Schiffmann; D Henschler
Induction of unscheduled DNA synthesis and micronucleus formation in Syrian hamster embryo fibroblasts treated with cysteine S-conjugates of chlorinated hydrocarbons.
Cell biology and toxicology 1988;4(4):393-403.
1988: W Dekant; Spyros Vamvakas; D Henschler; MW Anders
Enzymatic conjugation of hexachloro-1,3-butadiene with glutathione. Formation of 1-(glutathion-S-yl)-1,2,3,4,4-pentachlorobuta-1,3-diene and 1,4-bis(glutathion-S-yl)-1,2,3,4-tetrachlorobuta-1,3-diene.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(5):701-6.
1988: Spyros Vamvakas; A A Elfarra; Wolfgang Dekant; D Henschler; MW Anders
Mutagenicity of amino acid and glutathione S-conjugates in the Ames test.
Mutation research 1988;206(1):83-90.
1988: Wolfgang Dekant; D Schrenk; Spyros Vamvakas; D Henschler
Metabolism of hexachloro-1,3-butadiene in mice: in vivo and in vitro evidence for activation by glutathione conjugation.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(7):803-16.
1988: Spyros Vamvakas; F J Kordowich; Wolfgang Dekant; T Neudecker; D Henschler
Mutagenicity of hexachloro-1,3-butadiene and its S-conjugates in the Ames test--role of activation by the mercapturic acid pathway in its nephrocarcinogenicity.
Carcinogenesis 1988;9(6):907-10.
1988: Wolfgang Dekant; K Berthold; Spyros Vamvakas; D Henschler; MW Anders
Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate beta-lyase.
Chemical research in toxicology 1988;1(3):175-8.
1988: Spyros Vamvakas; K Berthold; Wolfgang Dekant; D Henschler
Bacterial cysteine conjugate beta-lyase and the metabolism of cysteine S-conjugates: structural requirements for the cleavage of S-conjugates and the formation of reactive intermediates.
Chemico-biological interactions 1988;65(1):59-71.
1988: Wolfgang Dekant; K Berthold; Spyros Vamvakas; D Henschler
Thioacylating agents as ultimate intermediates in the beta-lyase catalysed metabolism of S-(pentachloro-butadienyl)-L-cysteine.
Chemico-biological interactions 1988;67(1-2):139-48.
1988: Spyros Vamvakas; D A Müller; Wolfgang Dekant; D Henschler
DNA-binding of sulfur-containing metabolites from 35S-(pentachlorobutadienyl)-L-cysteine in bacteria and isolated renal tubular cells.
Drug metabolism and drug interactions 1988;6(3-4):349-58.
1987: Spyros Vamvakas; Wolfgang Dekant; K Berthold; S Schmidt; D Wild; D Henschler
Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates.
Biochemical pharmacology 1987;36(17):2741-8.
1987: Wolfgang Dekant; G Martens; Spyros Vamvakas; M Metzler; D Henschler
Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(5):702-9.
1986: Wolfgang Dekant; Spyros Vamvakas; K Berthold; S Schmidt; D Wild; D Henschler
Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene.
Chemico-biological interactions 1986;60(1):31-45.