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Linda Van Aelst

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
8
Boettner, Benjamin
7
Govek, Eve-Ellen
7
Wigler, Michael
6
Thevelein, Johan
5
Zhao, Mingming
5
Newey, Sarah
4
D'Souza-Schorey, Crislyn
4
Bar-Sagi, Dafna
4
Zhu, Julius
4
Pandolfi, Pier Paolo
3
Westwick, JK
3
White, Michael
3
Qin, Yi
3
Zhu, Yinghua
3
Di Cristofano, Antonio

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Publications

TOP 3
Boettner Benjamin; Van Aelst Linda
Control of cell adhesion dynamics by Rap1 signaling.
Nakano-Kobayashi Akiko; Kasri Nael Nadif; Newey Sarah E; Van Aelst Linda
The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.
Nadif Kasri Nael; Nakano-Kobayashi Akiko; Malinow Roberto; Li Bo; Van Aelst Linda
The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors.

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All Publications

2009: Boettner Benjamin; Van Aelst Linda
Control of cell adhesion dynamics by Rap1 signaling.
Current opinion in cell biology 2009;21(5):684-93.
2009: Nakano-Kobayashi Akiko; Kasri Nael Nadif; Newey Sarah E; Van Aelst Linda
The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.
Current biology : CB 2009;19(13):1133-9.
2009: Nadif Kasri Nael; Nakano-Kobayashi Akiko; Malinow Roberto; Li Bo; Van Aelst Linda
The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors.
Genes & development 2009;23(11):1289-302.
2008: Hu Hailan; Qin Yi; Bochorishvili Genrieta; Zhu Yinghua; van Aelst Linda; Zhu J Julius
Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(31):7847-62.
2008: Sordella Raffaella; Van Aelst Linda
Dialogue between RhoA/ROCK and members of the Par complex in cell polarity.
Developmental cell 2008;14(2):150-2.
2008: Nadif Kasri Nael; Van Aelst Linda
Rho-linked genes and neurological disorders.
Pflügers Archiv : European journal of physiology 2008;455(5):787-97.
2008: Kasri Nael Nadif; Govek Eve-Ellen; Van Aelst Linda
Characterization of oligophrenin-1, a RhoGAP lost in patients affected with mental retardation: lentiviral injection in organotypic brain slice cultures.
Methods in enzymology 2008;439():255-66.
2007: Boettner Benjamin; Van Aelst Linda
The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis.
Molecular and cellular biology 2007;27(22):7966-80.
2006: Watabe-Uchida Mitsuko; Govek Eve-Ellen; Van Aelst Linda
Regulators of Rho GTPases in neuronal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(42):10633-5.
2006: Watabe-Uchida Mitsuko; John Keisha A; Janas Justyna A; Newey Sarah E; Van Aelst Linda
The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.
Neuron 2006;51(6):727-39.
2006: Zhao Mingming; Janas Justyna A; Niki Masaru; Pandolfi Pier Paolo; Van Aelst Linda
Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.
Molecular and cellular biology 2006;26(7):2479-89.
2006: Janas Justyna; Skowronski Jacek; Van Aelst Linda
Lentiviral delivery of RNAi in hippocampal neurons.
Methods in enzymology 2006;406():593-605.
2005: Qin Yi; Zhu Yinghua; Baumgart Joel P; Stornetta Ruth L; Seidenman Kenneth; Mack Volker; van Aelst Linda; Zhu J Julius
State-dependent Ras signaling and AMPA receptor trafficking.
Genes & development 2005;19(17):2000-15.
2005: Newey Sarah E; Velamoor Vanisree; Govek Eve-Ellen; Van Aelst Linda
Rho GTPases, dendritic structure, and mental retardation.
Journal of neurobiology 2005;64(1):58-74.
2005: Zhu Yinghua; Pak Daniel; Qin Yi; McCormack Stefanie G; Kim Myung J; Baumgart Joel P; Velamoor Vanisree; Auberson Yves P; Osten Pavel; van Aelst Linda; Sheng Morgan; Zhu J Julius
Rap2-JNK removes synaptic AMPA receptors during depotentiation.
Neuron 2005;46(6):905-16.
2005: Govek Eve-Ellen; Newey Sarah E; Van Aelst Linda
The role of the Rho GTPases in neuronal development.
Genes & development 2005;19(1):1-49.
2004: Niki Masaru; Di Cristofano Antonio; Zhao Mingming; Honda Hiroaki; Hirai Hisamaru; Van Aelst Linda; Cordon-Cardo Carlos; Pandolfi Pier Paolo
Role of Dok-1 and Dok-2 in leukemia suppression.
The Journal of experimental medicine 2004;200(12):1689-95.
2004: Van Aelst Linda; Cline Hollis T
Rho GTPases and activity-dependent dendrite development.
Current opinion in neurobiology 2004;14(3):297-304.
2004: Govek Eve-Ellen; Newey Sarah E; Akerman Colin J; Cross Justin R; Van der Veken Lieven; Van Aelst Linda
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis.
Nature neuroscience 2004;7(4):364-72.
2003: Boettner Benjamin; Harjes Phoebe; Ishimaru Satoshi; Heke Michael; Fan Hong Qing; Qin Yi; Van Aelst Linda; Gaul Ulrike
The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo.
Genetics 2003;165(1):159-69.
2002: Zhu J Julius; Qin Yi; Zhao Mingming; Van Aelst Linda; Malinow Roberto
Ras and Rap control AMPA receptor trafficking during synaptic plasticity.
Cell 2002;110(4):443-55.
2002: Boettner Benjamin; Van Aelst Linda
The RASputin effect.
Genes & development 2002;16(16):2033-8.
2002: Van Aelst Linda; Symons Marc
Role of Rho family GTPases in epithelial morphogenesis.
Genes & development 2002;16(9):1032-54.
2002: Boettner Benjamin; Van Aelst Linda
The role of Rho GTPases in disease development.
Gene 2002;286(2):155-74.
2002: Schmitz Arndt A P; Lucito Robert; Van Aelst Linda
Using cDNA-representational difference analysis (cDNA-RDA) in combination with microarrays to identify Rac regulated genes.
Methods in molecular biology (Clifton, N.J.) 2002;189():25-43.
2001: Gumienny T L; Brugnera E; Tosello-Trampont A C; Kinchen J M; Haney L B; Nishiwaki K; Walk S F; Nemergut M E; Macara I G; Francis R; Schedl T; Qin Y; Van Aelst L; Hengartner M O; Ravichandran K S
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Cell 2001;107(1):27-41.
2001: Di Cristofano A; Niki M; Zhao M; Karnell F G; Clarkson B; Pear W S; Van Aelst L; Pandolfi P P
p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).
The Journal of experimental medicine 2001;194(3):275-84.
2001: Zhao M; Schmitz A A; Qin Y; Di Cristofano A; Pandolfi P P; Van Aelst L
Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation.
The Journal of experimental medicine 2001;194(3):265-74.
2001: Boettner B; Herrmann C; Van Aelst L
Ras and Rap1 interaction with AF-6 effector target.
Methods in enzymology 2001;332():151-68.
2000: Schmitz A A; Govek E E; Böttner B; Van Aelst L
Rho GTPases: signaling, migration, and invasion.
Experimental cell research 2000;261(1):1-12.
2000: Boettner B; Govek E E; Cross J; Van Aelst L
The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9064-9.
2000: Boshans R L; Szanto S; van Aelst L; D'Souza-Schorey C
ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA.
Molecular and cellular biology 2000;20(10):3685-94.
2000: Li Z; Van Aelst L; Cline H T
Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo.
Nature neuroscience 2000;3(3):217-25.
1999: Boettner B; Van Aelst L
Rac and Cdc42 effectors.
Progress in molecular and subcellular biology 1999;22():135-58.
1998: Lin A W; Barradas M; Stone J C; van Aelst L; Serrano M; Lowe S W
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling.
Genes & development 1998;12(19):3008-19.
1998: D'Souza-Schorey C; Boettner B; Van Aelst L
Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes.
Molecular and cellular biology 1998;18(7):3936-46.
1997: D'Souza-Schorey C; Boshans R L; McDonough M; Stahl P D; Van Aelst L
A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.
The EMBO journal 1997;16(17):5445-54.
1997: Van Aelst L; D'Souza-Schorey C
Rho GTPases and signaling networks.
Genes & development 1997;11(18):2295-322.
1997: Han J; Das B; Wei W; Van Aelst L; Mosteller R D; Khosravi-Far R; Westwick J K; Der C J; Broek D
Lck regulates Vav activation of members of the Rho family of GTPases.
Molecular and cellular biology 1997;17(3):1346-53.
1997: Westwick J K; Lambert Q T; Clark G J; Symons M; Van Aelst L; Pestell R G; Der C J
Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.
Molecular and cellular biology 1997;17(3):1324-35.
1996: Joneson T; McDonough M; Bar-Sagi D; Van Aelst L
RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase.
Science (New York, N.Y.) 1996;274(5291):1374-6.
1996: Barr M M; Tu H; Van Aelst L; Wigler M
Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.
Molecular and cellular biology 1996;16(10):5597-603.
1996: Van Aelst L; Joneson T; Bar-Sagi D
Identification of a novel Rac1-interacting protein involved in membrane ruffling.
The EMBO journal 1996;15(15):3778-86.
1996: Khosravi-Far R; White M A; Westwick J K; Solski P A; Chrzanowska-Wodnicka M; Van Aelst L; Wigler M H; Der C J
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.
Molecular and cellular biology 1996;16(7):3923-33.
1995: Yang S S; Van Aelst L; Bar-Sagi D
Differential interactions of human Sos1 and Sos2 with Grb2.
The Journal of biological chemistry 1995;270(31):18212-5.
1995: White M A; Nicolette C; Minden A; Polverino A; Van Aelst L; Karin M; Wigler M H
Multiple Ras functions can contribute to mammalian cell transformation.
Cell 1995;80(4):533-41.
1994: Jung V; Wei W; Ballester R; Camonis J; Mi S; Van Aelst L; Wigler M; Broek D
Two types of RAS mutants that dominantly interfere with activators of RAS.
Molecular and cellular biology 1994;14(6):3707-18.
1994: Van Aelst L; White M A; Wigler M H
Ras partners.
Cold Spring Harbor symposia on quantitative biology 1994;59():181-6.
1993: Van Aelst L; Barr M; Marcus S; Polverino A; Wigler M
Complex formation between RAS and RAF and other protein kinases.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6213-7.
1993: Chardin P; Camonis J H; Gale N W; van Aelst L; Schlessinger J; Wigler M H; Bar-Sagi D
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Science (New York, N.Y.) 1993;260(5112):1338-43.
1993: Van Aelst L; Hohmann S; Bulaya B; de Koning W; Sierkstra L; Neves M J; Luyten K; Alijo R; Ramos J; Coccetti P
Molecular cloning of a gene involved in glucose sensing in the yeast Saccharomyces cerevisiae.
Molecular microbiology 1993;8(5):927-43.
1991: Van Aelst L; Hohmann S; Zimmermann F K; Jans A W; Thevelein J M
A yeast homologue of the bovine lens fibre MIP gene family complements the growth defect of a Saccharomyces cerevisiae mutant on fermentable sugars but not its defect in glucose-induced RAS-mediated cAMP signalling.
The EMBO journal 1991;10(8):2095-104.
1991: van Aelst L; Jans A W; Thevelein J M
Involvement of the CDC25 gene product in the signal transmission pathway of the glucose-induced RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae.
Journal of general microbiology 1991;137(2):341-9.
1990: Van Aelst L; Boy-Marcotte E; Camonis J H; Thevelein J M; Jacquet M
The C-terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose-induced modulation of cAMP level in Saccharomyces cerevisiae.
European journal of biochemistry / FEBS 1990;193(3):675-80.
1990: Mbonyi K; van Aelst L; Argüelles J C; Jans A W; Thevelein J M
Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase.
Molecular and cellular biology 1990;10(9):4518-23.
1990: Argüelles J C; Mbonyi K; Van Aelst L; Vanhalewyn M; Jans A W; Thevelein J M
Absence of glucose-induced cAMP signaling in the Saccharomyces cerevisiae mutants cat1 and cat3 which are deficient in derepression of glucose-repressible proteins.
Archives of microbiology 1990;154(2):199-205.
1989: Thevelein J M; Beullens M; Mbonyi K; Van Aelst L
The glucose-induced CDC25- and RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae.
Yeast (Chichester, England) 1989;5 Spec No():S421-5.

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