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Victor van Beusechem

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Verheije Monique H; Lamfers Martine L M; Würdinger Thomas; Grinwis Guy C M; Gerritsen Winald R; van Beusechem Victor W; Rottier Peter J M
Coronavirus genetically redirected to the epidermal growth factor receptor exhibits effective antitumor activity against a malignant glioblastoma.
Schagen Frederik H E; Graat Harm C A; Carette Jan E; Vellinga Jort; van Geer Michael A; Hoeben Rob C; Dermody Terence S; van Beusechem Victor W
Replacement of native adenovirus receptor-binding sites with a new attachment moiety diminishes hepatic tropism and enhances bioavailability in mice.
Graat Harm C A; van Beusechem Victor W; Schagen Frederik H E; Witlox M Adhiambo; Kleinerman Eugenie S; Helder Marco N; Gerritsen Winald R; Kaspers Gertjan J L; Wuisman Paul I J M
Intravenous administration of the conditionally replicative adenovirus Ad5-Delta24RGD induces regression of osteosarcoma lung metastases.

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2009: Verheije Monique H; Lamfers Martine L M; Würdinger Thomas; Grinwis Guy C M; Gerritsen Winald R; van Beusechem Victor W; Rottier Peter J M
Coronavirus genetically redirected to the epidermal growth factor receptor exhibits effective antitumor activity against a malignant glioblastoma.
Journal of virology 2009;83(15):7507-16.
2008: Schagen Frederik H E; Graat Harm C A; Carette Jan E; Vellinga Jort; van Geer Michael A; Hoeben Rob C; Dermody Terence S; van Beusechem Victor W
Replacement of native adenovirus receptor-binding sites with a new attachment moiety diminishes hepatic tropism and enhances bioavailability in mice.
Human gene therapy 2008;19(8):783-94.
2008: Graat Harm C A; van Beusechem Victor W; Schagen Frederik H E; Witlox M Adhiambo; Kleinerman Eugenie S; Helder Marco N; Gerritsen Winald R; Kaspers Gertjan J L; Wuisman Paul I J M
Intravenous administration of the conditionally replicative adenovirus Ad5-Delta24RGD induces regression of osteosarcoma lung metastases.
Molecular cancer 2008;7():9.
2007: Lamfers Martine L M; Idema Sander; Bosscher Lisette; Heukelom Stan; Moeniralm Sharif; van der Meulen-Muileman Ida H; Overmeer Renée M; van der Valk Paul; van Beusechem Victor W; Gerritsen Winald R; Vandertop W Peter; Dirven Clemens M F
Differential effects of combined Ad5- delta 24RGD and radiation therapy in in vitro versus in vivo models of malignant glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(24):7451-8.
2007: Idema Sander; Lamfers Martine L M; van Beusechem Victor W; Noske David P; Heukelom Stan; Moeniralm Sharif; Gerritsen Winald R; Vandertop W Peter; Dirven Clemens M F
AdDelta24 and the p53-expressing variant AdDelta24-p53 achieve potent anti-tumor activity in glioma when combined with radiotherapy.
The journal of gene medicine 2007;9(12):1046-56.
2007: Graat Harm C A; Carette Jan E; Schagen Frederik H E; Vassilev Lyubomir T; Gerritsen Winald R; Kaspers Gertjan J L; Wuisman Paul I J M; van Beusechem Victor W
Enhanced tumor cell kill by combined treatment with a small-molecule antagonist of mouse double minute 2 and adenoviruses encoding p53.
Molecular cancer therapeutics 2007;6(5):1552-61.
2007: Carette Jan E; Graat Harm C A; Schagen Frederik H E; Mastenbroek D C Jeroen; Rots Marianne G; Haisma Hidde J; Groothuis Geny M M; Schaap Gerard R; Bras Johannes; Kaspers Gertjan J L; Wuisman Paul I J M; Gerritsen Winald R; van Beusechem Victor W
A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor.
Virology 2007;361(1):56-67.
2006: Würdinger T; Verheije M H; van der Aa L M; Bosch B J; de Haan C A M; van Beusechem V W; Gerritsen W R; Rottier P J M
Antibody-mediated targeting of viral vectors to the Fc receptor expressed on acute myeloid leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(12):2182-4.
2006: Lamfers Martine L M; Fulci Giulia; Gianni Davide; Tang Yi; Kurozumi Kazuhiko; Kaur Balveen; Moeniralm Sharif; Saeki Yoshinaga; Carette Jan E; Weissleder Ralph; Vandertop W Peter; van Beusechem Victor W; Dirven Clemens M F; Chiocca E Antonio
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(6):779-88.
2006: Graat H C A; Witlox M A; Schagen F H E; Kaspers G J L; Helder M N; Bras J; Schaap G R; Gerritsen W R; Wuisman P I J M; van Beusechem V W
Different susceptibility of osteosarcoma cell lines and primary cells to treatment with oncolytic adenovirus and doxorubicin or cisplatin.
British journal of cancer 2006;94(12):1837-44.
2006: Schagen Frederik H E; Wensveen Felix M; Carette Jan E; Dermody Terence S; Gerritsen Winald R; van Beusechem Victor W
Genetic targeting of adenovirus vectors using a reovirus sigma1-based attachment protein.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(5):997-1005.
2006: Verheije M H; Würdinger T; van Beusechem V W; de Haan C A M; Gerritsen W R; Rottier P J M
Redirecting coronavirus to a nonnative receptor through a virus-encoded targeting adapter.
Journal of virology 2006;80(3):1250-60.
2005: Würdinger T; Verheije M H; Broen K; Bosch B J; Haijema B J; de Haan C A M; van Beusechem V W; Gerritsen W R; Rottier P J M
Soluble receptor-mediated targeting of mouse hepatitis coronavirus to the human epidermal growth factor receptor.
Journal of virology 2005;79(24):15314-22.
2005: Heideman Daniëlle A M; Steenbergen Renske D M; van der Torre Jaco; Scheffner Martin; Alemany Ramon; Gerritsen Winald R; Meijer Chris J L M; Snijders Peter J F; van Beusechem Victor W
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1083-90.
2005: Heideman Daniëlle A M; Overmeer Renée M; van Beusechem Victor W; Lamers Wouter H; Hakvoort Theodorus B M; Snijders Peter J F; Craanen Mikael E; Offerhaus G Johan A; Meijer Chris J L M; Gerritsen Winald R
Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy.
Cancer gene therapy 2005;12(12):954-62.
2005: Lamfers Martine L M; Gianni Davide; Tung Ching-Hsuan; Idema Sander; Schagen Frederik H E; Carette Jan E; Quax Paul H A; Van Beusechem Victor W; Vandertop W Peter; Dirven Clemens M F; Chiocca E Antonio; Gerritsen Winald R
Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma.
Cancer research 2005;65(20):9398-405.
2005: Würdinger T; Verheije M H; Raaben M; Bosch B J; de Haan C A M; van Beusechem V W; Rottier P J M; Gerritsen W R
Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody.
Gene therapy 2005;12(18):1394-404.
2005: Carette Jan E; Graat Harm C A; Schagen Frederik H E; Abou El Hassan Mohamed A I; Gerritsen Winald R; van Beusechem Victor W
Replication-dependent transgene expression from a conditionally replicating adenovirus via alternative splicing to a heterologous splice-acceptor site.
The journal of gene medicine 2005;7(8):1053-62.
2005: van Beusechem Victor W; van den Doel Petra B; Gerritsen Winald R
Conditionally replicative adenovirus expressing degradation-resistant p53 for enhanced oncolysis of human cancer cells overexpressing murine double minute 2.
Molecular cancer therapeutics 2005;4(6):1013-8.
2005: Oosterhoff D; Pinedo H M; Witlox M A; Carette J E; Gerritsen W R; van Beusechem V W
Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24.
Gene therapy 2005;12(12):1011-8.
2005: Geoerger Birgit; van Beusechem Victor W; Opolon Paule; Morizet Jackie; Laudani Lysiane; Lecluse Yann; Barrois Michel; Idema Sander; Grill Jacques; Gerritsen Winald R; Vassal Gilles
Expression of p53, or targeting towards EGFR, enhances the oncolytic potency of conditionally replicative adenovirus against neuroblastoma.
The journal of gene medicine 2005;7(5):584-94.
2005: Graat Harm C A; Wuisman Paul I J M; van Beusechem Victor W; Carette Jan E; Gerritsen Winald R; Bras Johannes; Schaap Gerard R; Kaspers Gertjan J L; Ogose Akira; Gu Wenguang; Kawashima Hiroyuki; Hotta Tetsuo
Coxsackievirus and adenovirus receptor expression on primary osteosarcoma specimens and implications for gene therapy with recombinant adenoviruses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(6):2445-7; author reply 2447-8.
2005: Oosterhoff D; Overmeer R M; de Graaf M; van der Meulen I H; Giaccone G; van Beusechem V W; Haisma H J; Pinedo H M; Gerritsen W R
Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11.
British journal of cancer 2005;92(5):882-7.
2005: Grill Jacques; Lamfers Martine L M; van Beusechem Victor W; van der Valk Paul; Huisman Anne; Sminia Peter; Alemany Ramon; Curiel David T; Vandertop W Peter; Gerritsen Winald R; Dirven Clemens M F
Oncolytic virotherapy of meningiomas in vitro with replication-competent adenovirus.
Neurosurgery 2005;56(1):146-53; discussion 153-4.
2004: Geoerger Birgit; Vassal Gilles; Opolon Paule; Dirven Clemens M F; Morizet Jackie; Laudani Lysiane; Grill Jacques; Giaccone Giuseppe; Vandertop W Peter; Gerritsen Winald R; van Beusechem Victor W
Oncolytic activity of p53-expressing conditionally replicative adenovirus AdDelta24-p53 against human malignant glioma.
Cancer research 2004;64(16):5753-9.
2004: Oosterhoff Dinja; van Beusechem Victor W
Conditionally replicating adenoviruses as anticancer agents and ways to improve their efficacy.
Journal of experimental therapeutics & oncology 2004;4(1):37-57.
2004: Carette Jan E; Overmeer Renée M; Schagen Frederik H E; Alemany Ramon; Barski Oleg A; Gerritsen Winald R; Van Beusechem Victor W
Conditionally replicating adenoviruses expressing short hairpin RNAs silence the expression of a target gene in cancer cells.
Cancer research 2004;64(8):2663-7.
2004: Heideman Daniëlle A M; van Beusechem Victor W; Bloemena Elisabeth; Snijders Peter J F; Craanen Mikael E; Offerhaus G Johan A; Derksen Patrick W B; de Bruin Michiel; Witlox M Adhiambo; Molenaar Bonnie; Meijer Chris J L M; Gerritsen Winald R
Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4.
The journal of gene medicine 2004;6(3):317-27.
2004: Witlox Adhiambo M; Van Beusechem Victor W; Molenaar Bonnie; Bras Hans; Schaap Gerard R; Alemany Ramon; Curiel David T; Pinedo Herbert M; Wuisman Paul I J M; Gerritsen Winald R
Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):61-7.
2003: Grill Jacques; Geoerger Birgit; Lamfers Martine; Dirven Clemens; Van Beusechem Victor; Gerritsen Winald; Vassal Gilles
[Conditionally replicative adenoviruses: a second wind for cancer gene therapy]
Bulletin du cancer 2003;90(12):1039-48.
2003: van Beusechem V W; Mastenbroek D C J; van den Doel P B; Lamfers M L M; Grill J; Würdinger T; Haisma H J; Pinedo H M; Gerritsen W R
Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors.
Gene therapy 2003;10(23):1982-91.
2003: Oosterhoff Dinja; Witlox M Adhiambo; van Beusechem Victor W; Haisma Hidde J; Schaap Gerard R; Bras Johannes; Kruyt Frank A; Molenaar Bonnie; Boven Epie; Wuisman Paul I J M; Pinedo Herbert M; Gerritsen Winald R
Gene-directed enzyme prodrug therapy for osteosarcoma: sensitization to CPT-11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase-2.
Molecular cancer therapeutics 2003;2(8):765-71.
2003: Geoerger B; Grill J; Opolon P; Morizet J; Aubert G; Lecluse Y; van Beusechem V W; Gerritsen W R; Kirn D H; Vassal G
Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts.
British journal of cancer 2003;89(3):577-84.
2002: Dirven C M F; van Beusechem V W; Lamfers M L M; Grill J; Gerritsen W R; Vandertop W P
Oncolytic adenoviruses for treatment of brain tumours.
Expert opinion on biological therapy 2002;2(8):943-52.
2002: van Beusechem Victor W; van den Doel Petra B; Grill Jacques; Pinedo Herbert M; Gerritsen Winald R
Conditionally replicative adenovirus expressing p53 exhibits enhanced oncolytic potency.
Cancer research 2002;62(21):6165-71.
2002: Grill Jacques; Lamfers Martine L M; van Beusechem Victor W; Dirven Clemens M; Pherai D Shareen; Kater Mathijs; Van der Valk Paul; Vogels Ronald; Vandertop W Peter; Pinedo Herbert M; Curiel David T; Gerritsen Winald R
The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):609-14.
2002: Lamfers Martine L M; Grill Jacques; Dirven Clemens M F; Van Beusechem Victor W; Geoerger Birgit; Van Den Berg Jaap; Alemany Ramon; Fueyo Juan; Curiel David T; Vassal Gilles; Pinedo Herbert M; Vandertop W Peter; Gerritsen Winald R
Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.
Cancer research 2002;62(20):5736-42.
2002: Heideman Daniëlle A M; van Beusechem Victor W; Offerhaus G Johan A; Wickham Thomas J; Roelvink Peter W; Craanen Mikael E; Pinedo Herbert M; Meijer Chris J L M; Gerritsen Winald R
Selective gene transfer into primary human gastric tumors using epithelial cell adhesion molecule-targeted adenoviral vectors with ablated native tropism.
Human gene therapy 2002;13(14):1677-85.
2002: Oosterhoff D; Pinedo H M; van der Meulen I H; de Graaf M; Sone T; Kruyt F A; van Beusechem V W; Haisma H J; Gerritsen W R
Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
British journal of cancer 2002;87(6):659-64.
2002: Witlox M A; Van Beusechem V W; Grill J; Haisma H J; Schaap G; Bras J; Van Diest P; De Gast A; Curiel D T; Pinedo H M; Gerritsen W R; Wuisman P I J M
Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma.
The journal of gene medicine 2002;4(5):510-6.
2002: Dirven Clemens M F; Grill Jacques; Lamfers Martine L M; Van der Valk Paul; Leonhart Angelique M; Van Beusechem Victor W; Haisma Hidde J; Pinedo Herbert M; Curiel David T; Vandertop W Peter; Gerritsen Winald R
Gene therapy for meningioma: improved gene delivery with targeted adenoviruses.
Journal of neurosurgery 2002;97(2):441-9.
2002: van der Poel H G; Molenaar B; van Beusechem V W; Haisma H J; Rodriguez R; Curiel D T; Gerritsen W R
Epidermal growth factor receptor targeting of replication competent adenovirus enhances cytotoxicity in bladder cancer.
The Journal of urology 2002;168(1):266-72.
2002: van Beusechem Victor W; Grill Jacques; Mastenbroek D C Jeroen; Wickham Thomas J; Roelvink Peter W; Haisma Hidde J; Lamfers Martine L M; Dirven Clemens M F; Pinedo Herbert M; Gerritsen Winald R
Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished.
Journal of virology 2002;76(6):2753-62.
2001: Heideman D A; Snijders P J; Craanen M E; Bloemena E; Meijer C J; Meuwissen S G; van Beusechem V W; Pinedo H M; Curiel D T; Haisma H J; Gerritsen W R
Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors.
Cancer gene therapy 2001;8(5):342-51.
2001: Grill J; Van Beusechem V W; Van Der Valk P; Dirven C M; Leonhart A; Pherai D S; Haisma H J; Pinedo H M; Curiel D T; Gerritsen W R
Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3):641-50.
2000: van Beusechem V W; van Rijswijk A L; van Es H H; Haisma H J; Pinedo H M; Gerritsen W R
Recombinant adenovirus vectors with knobless fibers for targeted gene transfer.
Gene therapy 2000;7(22):1940-6.
2000: Haisma H J; Grill J; Curiel D T; Hoogeland S; van Beusechem V W; Pinedo H M; Gerritsen W R
Targeting of adenoviral vectors through a bispecific single-chain antibody.
Cancer gene therapy 2000;7(6):901-4.

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Victor van Beusechem

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