Peter van Bladeren

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Punt Ans; Paini Alicia; Boersma Marelle G; Freidig Andreas P; Delatour Thierry; Scholz Gabriele; Schilter Benoît; van Bladeren Peter J; Rietjens Ivonne M C M
Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats.
Vermeulen Martijn; Boerboom Anne-Marie M J F; Blankvoort Barry M G; Aarts Jac M M J G; Rietjens Ivonne M C M; van Bladeren Peter J; Vaes Wouter H J
Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.
Punt Ans; Freidig Andreas P; Delatour Thierry; Scholz Gabriele; Boersma Marelle G; Schilter Benoît; van Bladeren Peter J; Rietjens Ivonne M C M
A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat.

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2009: Punt Ans; Paini Alicia; Boersma Marelle G; Freidig Andreas P; Delatour Thierry; Scholz Gabriele; Schilter Benoît; van Bladeren Peter J; Rietjens Ivonne M C M
Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(2):255-69.
2009: Vermeulen Martijn; Boerboom Anne-Marie M J F; Blankvoort Barry M G; Aarts Jac M M J G; Rietjens Ivonne M C M; van Bladeren Peter J; Vaes Wouter H J
Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.
Toxicology in vitro : an international journal published in association with BIBRA 2009;23(4):617-21.
2008: Punt Ans; Freidig Andreas P; Delatour Thierry; Scholz Gabriele; Boersma Marelle G; Schilter Benoît; van Bladeren Peter J; Rietjens Ivonne M C M
A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat.
Toxicology and applied pharmacology 2008;231(2):248-59.
2008: Brand Walter; van der Wel Petronella A I; Rein Maarit J; Barron Denis; Williamson Gary; van Bladeren Peter J; Rietjens Ivonne M C M
Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(9):1794-802.
2007: Usta Mustafa; Wortelboer Heleen M; Vervoort Jacques; Boersma Marelle G; Rietjens Ivonne M C M; van Bladeren Peter J; Cnubben Nicole H P
Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells.
Chemical research in toxicology 2007;20(12):1895-902.
2007: Punt Ans; Delatour Thierry; Scholz Gabriele; Schilter Benoît; van Bladeren Peter J; Rietjens Ivonne M C M
Tandem mass spectrometry analysis of N2-(trans-Isoestragol-3'-yl)-2'-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1'-hydroxyestragole.
Chemical research in toxicology 2007;20(7):991-8.
2007: Grigorov Martin G; van Bladeren Peter J
Functional peptides by genome reverse engineering.
Current opinion in drug discovery & development 2007;10(3):341-6.
2007: Jeurissen Suzanne M F; Punt Ans; Boersma Marelle G; Bogaards Jan J P; Fiamegos Yiannis C; Schilter Benoit; van Bladeren Peter J; Cnubben Nicole H P; Rietjens Ivonne M C M
Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.
Chemical research in toxicology 2007;20(5):798-806.
2006: Brand Walter; Schutte Maaike E; Williamson Gary; van Zanden Jelmer J; Cnubben Nicole H P; Groten John P; van Bladeren Peter J; Rietjens Ivonne M C M
Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(9):508-19.
2006: Vermeulen Martijn; van den Berg Robin; Freidig Andreas P; van Bladeren Peter J; Vaes Wouter H J
Association between consumption of cruciferous vegetables and condiments and excretion in urine of isothiocyanate mercapturic acids.
Journal of agricultural and food chemistry 2006;54(15):5350-8.
2006: Boerboom Anne-Marie J F; Vermeulen Martijn; van der Woude Hester; Bremer Birgit I; Lee-Hilz Yee Y; Kampman Ellen; van Bladeren Peter J; Rietjens Ivonne M C M; Aarts Jac M M J G
Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity.
Biochemical pharmacology 2006;72(2):217-26.
2005: Cnubben Nicole H P; Wortelboer Heleen M; van Zanden Jelmer J; Rietjens Ivonne M C M; van Bladeren Peter J
Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance.
Expert opinion on drug metabolism & toxicology 2005;1(2):219-32.
2005: van Zanden Jelmer J; de Mul Anika; Wortelboer Heleen M; Usta Mustafa; van Bladeren Peter J; Rietjens Ivonne M C M; Cnubben Nicole H P
Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin.
Biochemical pharmacology 2005;69(11):1657-65.
2005: Wortelboer Heleen M; Usta Mustafa; van Zanden Jelmer J; van Bladeren Peter J; Rietjens Ivonne M C M; Cnubben Nicole H P
Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds.
Biochemical pharmacology 2005;69(12):1879-90.
2005: van Erk Marjan J; Roepman Paul; van der Lende Ted R; Stierum Rob H; Aarts Jac M M J G; van Bladeren Peter J; van Ommen Ben
Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro.
European journal of nutrition 2005;44(3):143-56.
2005: Heijne Wilbert H M; Lamers Robert-Jan A N; van Bladeren Peter J; Groten John P; van Nesselrooij Joop H J; van Ommen Ben
Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis.
Toxicologic pathology 2005;33(4):425-33.
2004: Heijne Wilbert H M; Slitt Angela L; van Bladeren Peter J; Groten John P; Klaassen Curtis D; Stierum Rob H; van Ommen Ben
Bromobenzene-induced hepatotoxicity at the transcriptome level.
Toxicological sciences : an official journal of the Society of Toxicology 2004;79(2):411-22.
2004: van Zanden Jelmer J; Geraets Liesbeth; Wortelboer Heleen M; van Bladeren Peter J; Rietjens Ivonne M C M; Cnubben Nicole H P
Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.
Biochemical pharmacology 2004;67(8):1607-17.
2003: Wortelboer Heleen M; Usta Mustafa; van der Velde Astrid E; Boersma Marelle G; Spenkelink Bert; van Zanden Jelmer J; Rietjens Ivonne M C M; van Bladeren Peter J; Cnubben Nicole H P
Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.
Chemical research in toxicology 2003;16(12):1642-51.
2003: Dommels Yvonne E M; Heemskerk Suzanne; van den Berg Hans; Alink Gerrit M; van Bladeren Peter J; van Ommen Ben
Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(12):1739-47.
2003: Awad Hanem M; Boersma Marelle G; Boeren Sjef; Van Bladeren Peter J; Vervoort Jacques; Rietjens Ivonne M C M
Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation.
Chemical research in toxicology 2003;16(7):822-31.
2003: van Haaften Rachel I M; Haenen Guido R M M; van Bladeren Peter J; Bogaards Jan J P; Evelo Chris T A; Bast Aalt
Inhibition of various glutathione S-transferase isoenzymes by RRR-alpha-tocopherol.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(3):245-51.
2003: van Zanden Jelmer J; Ben Hamman Omar; van Iersel Marlou L P S; Boeren Sjef; Cnubben Nicole H P; Lo Bello Mario; Vervoort Jacques; van Bladeren Peter J; Rietjens Ivonne M C M
Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin.
Chemico-biological interactions 2003;145(2):139-48.
2003: Dommels Yvonne E M; Haring Merel M G; Keestra Nynke G M; Alink Gerrit M; van Bladeren Peter J; van Ommen Ben
The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE(2) synthesis and cytotoxicity in human colorectal carcinoma cell lines.
Carcinogenesis 2003;24(3):385-92.
2003: Heijne Wilbert H M; Stierum Rob H; Slijper Monique; van Bladeren Peter J; van Ommen Ben
Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach.
Biochemical pharmacology 2003;65(5):857-75.
2002: Awad Hanem M; Boersma Marelle G; Boeren Sjef; van der Woude Hester; van Zanden Jelmer; van Bladeren Peter J; Vervoort Jacques; Rietjens Ivonne M C M
Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system.
FEBS letters 2002;520(1-3):30-4.
2002: Boersma Marelle G; van der Woude Hester; Bogaards Jan; Boeren Sjef; Vervoort Jacques; Cnubben Nicole H P; van Iersel Marlou L P S; van Bladeren Peter J; Rietjens Ivonne M C M
Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases.
Chemical research in toxicology 2002;15(5):662-70.
2002: Awad Hanem M; Boersma Marelle G; Boeren Sjef; van Bladeren Peter J; Vervoort Jacques; Rietjens Ivonne M C M
The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent.
Chemical research in toxicology 2002;15(3):343-51.
2001: Bogaards J J; Freidig A P; van Bladeren P J
Prediction of isoprene diepoxide levels in vivo in mouse, rat and man using enzyme kinetic data in vitro and physiologically-based pharmacokinetic modelling.
Chemico-biological interactions 2001;138(3):247-65.
2001: Awad H M; Boersma M G; Boeren S; van Bladeren P J; Vervoort J; Rietjens I M
Structure-activity study on the quinone/quinone methide chemistry of flavonoids.
Chemical research in toxicology 2001;14(4):398-408.
2001: van Bladeren P J; Bogaards J J; Cnubben N H; Hissink E M
Modelling the responses to biological reactive intermediates: establishing the borderlines of risk.
Advances in experimental medicine and biology 2001;500():551-8.
2001: Rietjens I M; Awad H M; Boersma M G; van Iersel M L; Vervoort J; Van Bladeren P J
Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides.
Advances in experimental medicine and biology 2001;500():11-21.
2000: Bogaards J J; Bertrand M; Jackson P; Oudshoorn M J; Weaver R J; van Bladeren P J; Walther B
Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(12):1131-52.
2000: Bogaards J J; Hissink E M; Briggs M; Weaver R; Jochemsen R; Jackson P; Bertrand M; van Bladeren P J
Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(2):117-24.
2000: Hissink A M; Wormhoudt L W; Sherratt P J; Hayes J D; Commandeur J N; Vermeulen N P; van Bladeren P J
A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(8):707-16.
1999: Cashman J R; Xiong Y; Lin J; Verhagen H; van Poppel G; van Bladeren P J; Larsen-Su S; Williams D E
In vitro and in vivo inhibition of human flavin-containing monooxygenase form 3 (FMO3) in the presence of dietary indoles.
Biochemical pharmacology 1999;58(6):1047-55.
1999: van Iersel M L; Verhagen H; van Bladeren P J
The role of biotransformation in dietary (anti)carcinogenesis.
Mutation research 1999;443(1-2):259-70.
1999: van Iersel M L; Cnubben N H; Smink N; Koeman J H; van Bladeren P J
Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system.
Biochemical pharmacology 1999;57(12):1383-90.
1999: Bogaards J J; Venekamp J C; Salmon F G; van Bladeren P J
Conjugation of isoprene monoepoxides with glutathione, catalyzed by alpha, mu, pi and theta-class glutathione S-transferases of rat and man.
Chemico-biological interactions 1999;117(1):1-14.
1998: van Iersel M L; van Lipzig M M; Rietjens I M; Vervoort J; van Bladeren P J
GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid.
FEBS letters 1998;441(1):153-7.
1998: Sherratt P J; Manson M M; Thomson A M; Hissink E A; Neal G E; van Bladeren P J; Green T; Hayes J D
Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1.
The Biochemical journal 1998;335 ( Pt 3)():619-30.
1998: Cnubben N H; Rommens A J; Oudshoorn M J; Van Bladeren P J
Glutathione-dependent biotransformation of the alkylating drug thiotepa and transport of its metabolite monoglutathionylthiotepa in human MCF-7 breast cancer cells.
Cancer research 1998;58(20):4616-23.
1998: Wormhoudt L W; Hissink A M; Commandeur J N; van Bladeren P J; Vermeulen N P
Disposition of 1,2-[14C]Dibromoethane in male Wistar rats.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(5):437-47.
1998: Cassee F R; Groten J P; van Bladeren P J; Feron V J
Toxicological evaluation and risk assessment of chemical mixtures.
Critical reviews in toxicology 1998;28(1):73-101.
1998: Feron V J; Groten J P; van Bladeren P J
Exposure of humans to complex chemical mixtures: hazard identification and risk assessment.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1998;20():363-73.
1997: van Iersel M L; Ploemen J P; Lo Bello M; Federici G; van Bladeren P J
Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1.
Chemico-biological interactions 1997;108(1-2):67-78.
1997: Evers R; Cnubben N H; Wijnholds J; van Deemter L; van Bladeren P J; Borst P
Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.
FEBS letters 1997;419(1):112-6.
1997: Ouwerkerk-Mahadevan S; Tirona R G; Ripping R A; Ploemen J H; van Bladeren P J; Pang K S; van Boom J H; Mulder G J
Inhibition of glutathione conjugation by glutathione analogues in the perfused rat liver. Effect of esterification on the potency of gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(10):1137-43.
1997: Hissink A M; Van Ommen B; Krüse J; Van Bladeren P J
A physiologically based pharmacokinetic (PB-PK) model for 1,2-dichlorobenzene linked to two possible parameters of toxicity.
Toxicology and applied pharmacology 1997;145(2):301-10.
1997: Hissink A M; Oudshoorn M J; Van Ommen B; Van Bladeren P J
Species and strain differences in the hepatic cytochrome P450-mediated biotransformation of 1,4-dichlorobenzene.
Toxicology and applied pharmacology 1997;145(1):1-9.
1997: Wormhoudt L W; Commandeur J N; Ploemen J H; Abdoelgafoer R S; Makansi A; Van Bladeren P J; Vermeulen N P
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):508-15.
1997: Bogaards J J; Venekamp J C; van Bladeren P J
Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1.
Chemical research in toxicology 1997;10(3):310-7.
1997: Ploemen J P; Wormhoudt L W; Haenen G R; Oudshoorn M J; Commandeur J N; Vermeulen N P; de Waziers I; Beaune P H; Watabe T; van Bladeren P J
The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: the case of ethylene dibromide.
Toxicology and applied pharmacology 1997;143(1):56-69.
1997: Groten J P; Schoen E D; van Bladeren P J; Kuper C F; van Zorge J A; Feron V J
Subacute toxicity of a mixture of nine chemicals in rats: detecting interactive effects with a fractionated two-level factorial design.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1997;36(1):15-29.
1997: Hissink A M; Dunnewijk R; van Ommen B; van Bladeren P J
Kinetics and metabolism of 1,4-dichlorobenzene in male Wistar rats: no evidence for quinone metabolites.
Chemico-biological interactions 1997;103(1):17-33.
1996: Bogaards J J; Venekamp J C; van Bladeren P J
The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes.
Chemico-biological interactions 1996;102(3):169-82.
1996: Hissink A M; Oudshoorn M J; Van Ommen B; Haenen G R; Van Bladeren P J
Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.
Chemical research in toxicology 1996;9(8):1249-56.
1996: Nanjee M N; Verhagen H; van Poppel G; Rompelberg C J; van Bladeren P J; Miller N E
Do dietary phytochemicals with cytochrome P-450 enzyme-inducing activity increase high-density-lipoprotein concentrations in humans?
The American journal of clinical nutrition 1996;64(5):706-11.
1996: Iersel M L; Ploemen J P; Struik I; van Amersfoort C; Keyzer A E; Schefferlie J G; van Bladeren P J
Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal.
Chemico-biological interactions 1996;102(2):117-32.
1996: Wormhoudt L W; Ploemen J H; de Waziers I; Commandeur J N; Beaune P H; van Bladeren P J; Vermeulen N P
Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes.
Chemico-biological interactions 1996;101(3):175-92.
1996: Haenen H E; Spenkelink A; Teunissen C; Temmink J H; Koeman J H; van Bladeren P J
Transport and metabolism of glutathione conjugates of menadione and ethacrynic acid in confluent monolayers of rat renal proximal tubular cells.
Toxicology 1996;112(2):117-30.
1996: Ploemen J P; van Iersel M L; Wormhoudt L W; Commandeur J N; Vermeulen N P; van Bladeren P J
In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate.
Biochemical pharmacology 1996;52(2):197-204.
1996: Soffers A E; Ploemen J H; Moonen M J; Wobbes T; van Ommen B; Vervoort J; van Bladeren P J; Rietjens I M
Regioselectivity and quantitative structure-activity relationships for the conjugation of a series of fluoronitrobenzenes by purified glutathione S-transferase enzymes from rat and man.
Chemical research in toxicology 1996;9(3):638-46.
1996: Dirven H A; van Ommen B; van Bladeren P J
Glutathione conjugation of alkylating cytostatic drugs with a nitrogen mustard group and the role of glutathione S-transferases.
Chemical research in toxicology 1996;9(2):351-60.
1996: van der Aar E M; Buikema D; Commandeur J N; te Koppele J M; van Ommen B; van Bladeren P J; Vermeulen N P
Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(2):143-55.
1996: Jespersen S; Ploemen J H; van Bladeren P J; Niessen W M; Tjaden U R; van der Greef J
Identification of multiple target sites for a glutathione conjugate on glutathione-S-transferase by matrix-assisted laser desorption/ionization mass spectrometry.
Journal of mass spectrometry : JMS 1996;31(1):101-7.
1996: Peters M M; Lau S S; Dulik D; Murphy D; van Ommen B; van Bladeren P J; Monks T J
Metabolism of tert-butylhydroquinone to S-substituted conjugates in the male Fischer 344 rat.
Chemical research in toxicology 1996;9(1):133-9.
1996: Hissink A M; Van Ommen B; Van Bladeren P J
Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat: effect of pretreatment with phenobarbital.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(1):89-105.
1996: Rompelberg C J; Ploemen J H; Jespersen S; van der Greef J; Verhagen H; van Bladeren P J
Inhibition of rat, mouse, and human glutathione S-transferase by eugenol and its oxidation products.
Chemico-biological interactions 1996;99(1-3):85-97.
1996: Wormhoudt L W; Ploemen J H; Commandeur J N; van Ommen B; van Bladeren P; Vermeulen N P
Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats.
Chemico-biological interactions 1996;99(1-3):41-53.
1996: Hissink E; van Ommen B; Bogaards J J; van Bladeren P J
Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4-dichlorobenzene: the use of in vitro and in vivo metabolism, kinetics and PB-PK modeling.
Advances in experimental medicine and biology 1996;387():129-33.
1995: Rietjens I M; Steensma A; Den Besten C; van Tintelen G; Haas J; van Ommen B; van Bladeren P J
Comparative biotransformation of hexachlorobenzene and hexafluorobenzene in relation to the induction of porphyria.
European journal of pharmacology 1995;293(4):293-9.
1995: Feron V J; Groten J P; van Zorge J A; Cassee F R; Jonker D; van Bladeren P J
Toxicity studies in rats of simple mixtures of chemicals with the same or different target organs.
Toxicology letters 1995;82-83():505-12.
1995: Feron V J; Groten J P; Jonker D; Cassee F R; van Bladeren P J
Toxicology of chemical mixtures: challenges for today and the future.
Toxicology 1995;105(2-3):415-27.
1995: Haenen H E; Rietjens I M; Vervoort J; Temmink J H; van Bladeren P J
In vitro metabolism of 5-fluoro-2-glutathionyl-nitrobenzene by kidney proximal tubular cells studied by 19F-NMR.
Chemico-biological interactions 1995;98(2):97-112.
1995: Dirven H A; Megens L; Oudshoorn M J; Dingemanse M A; van Ommen B; van Bladeren P J
Glutathione conjugation of the cytostatic drug ifosfamide and the role of human glutathione S-transferases.
Chemical research in toxicology 1995;8(7):979-86.
1995: Bogaards J J; van Ommen B; Wolf C R; van Bladeren P J
Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes.
Toxicology and applied pharmacology 1995;132(1):44-52.
1995: Verhagen H; Poulsen H E; Loft S; van Poppel G; Willems M I; van Bladeren P J
Reduction of oxidative DNA-damage in humans by brussels sprouts.
Carcinogenesis 1995;16(4):969-70.
1995: Ploemen J H; Wormhoudt L W; van Ommen B; Commandeur J N; Vermeulen N P; van Bladeren P J
Polymorphism in the glutathione conjugation activity of human erythrocytes towards ethylene dibromide and 1,2-epoxy-3-(p-nitrophenoxy)-propane.
Biochimica et biophysica acta 1995;1243(3):469-76.
1995: Dirven H A; Dictus E L; Broeders N L; van Ommen B; van Bladeren P J
The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa.
Cancer research 1995;55(8):1701-6.
1995: Schielen P; Den Besten C; Vos J G; Van Bladeren P J; Seinen W; Bloksma N
Immune effects of hexachlorobenzene in the rat: role of metabolism in a 13-week feeding study.
Toxicology and applied pharmacology 1995;131(1):37-43.
1995: Morse D C; Wehler E K; van de Pas M; de Bie A T; van Bladeren P J; Brouwer A
Metabolism and biochemical effects of 3,3',4,4'-tetrachlorobiphenyl in pregnant and fetal rats.
Chemico-biological interactions 1995;95(1-2):41-56.
1995: Morse D C; Van Bladeren P J; Klasson Wehler E; Brouwer A
beta-Naphthoflavone- and self-induced metabolism of 3,3',4,4'-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant female and foetal rat.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(3):245-60.
1995: Feron V J; Woutersen R A; Arts J H; Cassee F R; de Vrijer F; van Bladeren P J
Safety evaluation of the mixture of chemicals at a specific workplace: theoretical considerations and a suggested two-step procedure.
Toxicology letters 1995;76(1):47-55.
1995: Goeptar A R; Commandeur J N; van Ommen B; van Bladeren P J; Vermeulen N P
Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway.
Chemical research in toxicology 1995;8(1):3-21.
1994: Dirven H A; van Ommen B; van Bladeren P J
Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione.
Cancer research 1994;54(23):6215-20.
1994: Dirven H A; Venekamp J C; van Ommen B; van Bladeren P J
The interaction of glutathione with 4-hydroxycyclophosphamide and phosphoramide mustard, studied by 31P nuclear magnetic resonance spectroscopy.
Chemico-biological interactions 1994;93(3):185-96.
1994: den Besten C; Brouwer A; Rietjens I M; van Bladeren P J
Biotransformation and toxicity of halogenated benzenes.
Human & experimental toxicology 1994;13(12):866-75.
1994: Groten J P; Koeman J H; van Nesselrooij J H; Luten J B; Fentener van Vlissingen J M; Stenhuis W S; van Bladeren P J
Comparison of renal toxicity after long-term oral administration of cadmium chloride and cadmium-metallothionein in rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;23(4):544-52.
1994: Ploemen J H; Johnson W W; Jespersen S; Vanderwall D; van Ommen B; van der Greef J; van Bladeren P J; Armstrong R N
Active-site tyrosyl residues are targets in the irreversible inhibition of a class Mu glutathione transferase by 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone.
The Journal of biological chemistry 1994;269(43):26890-7.
1994: Bogaards J J; Verhagen H; Willems M I; van Poppel G; van Bladeren P J
Consumption of Brussels sprouts results in elevated alpha-class glutathione S-transferase levels in human blood plasma.
Carcinogenesis 1994;15(5):1073-5.
1994: Ploemen J H; Van Schanke A; Van Ommen B; Van Bladeren P J
Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1.
Cancer research 1994;54(4):915-9.
1994: den Besten C; Bennik M M; van Iersel M; Peters M A; Teunis C; van Bladeren P J
Comparison of the urinary metabolite profiles of hexachlorobenzene and pentachlorobenzene in the rat.
Chemico-biological interactions 1994;90(2):121-37.
1994: Ploemen J H; Van Ommen B; De Haan A; Venekamp J C; Van Bladeren P J
Inhibition of human glutathione S-transferases by dopamine, alpha-methyldopa and their 5-S-glutathionyl conjugates.
Chemico-biological interactions 1994;90(1):87-99.
1993: Rompelberg C J; Verhagen H; van Bladeren P J
Effects of the naturally occurring alkenylbenzenes eugenol and trans-anethole on drug-metabolizing enzymes in the rat liver.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(9):637-45.
1993: den Besten C; van Bladeren P J; Duizer E; Vervoort J; Rietjens I M
Cytochrome P450-mediated oxidation of pentafluorophenol to tetrafluorobenzoquinone as the primary reaction product.
Chemical research in toxicology 1993;6(5):674-80.
1993: van Poppel G; Verhagen H; van 't Veer P; van Bladeren P J
Markers for cytogenetic damage in smokers: associations with plasma antioxidants and glutathione S-transferase mu.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1993;2(5):441-7.
1993: Ploemen J H; van Ommen B; Bogaards J J; van Bladeren P J
Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(8):913-23.
1993: Ploemen J H; van Ommen B; de Haan A; Schefferlie J G; van Bladeren P J
In vitro and in vivo reversible and irreversible inhibition of rat glutathione S-transferase isoenzymes by caffeic acid and its 2-S-glutathionyl conjugate.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(7):475-82.
1993: Bogaards J J; van Ommen B; van Bladeren P J
Interindividual differences in the in vitro conjugation of methylene chloride with glutathione by cytosolic glutathione S-transferase in 22 human liver samples.
Biochemical pharmacology 1993;45(10):2166-9.
1993: den Besten C; Bennik M H; Bruggeman I; Schielen P; Kuper F; Brouwer A; Koeman J H; Vos J G; Van Bladeren P J
The role of oxidative metabolism in hexachlorobenzene-induced porphyria and thyroid hormone homeostasis: a comparison with pentachlorobenzene in a 13-week feeding study.
Toxicology and applied pharmacology 1993;119(2):181-94.
1993: Jonker D; Woutersen R A; van Bladeren P J; Til H P; Feron V J
Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: comparison with the toxicity of the individual compounds.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(2):125-36.
1993: Ploemen J H; Bogaards J J; Veldink G A; van Ommen B; Jansen D H; van Bladeren P J
Isoenzyme selective irreversible inhibition of rat and human glutathione S-transferases by ethacrynic acid and two brominated derivatives.
Biochemical pharmacology 1993;45(3):633-9.
1993: Jonker D; Jones M A; van Bladeren P J; Woutersen R A; Til H P; Feron V J
Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(1):45-52.
1992: den Besten C; Ellenbroek M; van der Ree M A; Rietjens I M; van Bladeren P J
The involvement of primary and secondary metabolism in the covalent binding of 1,2- and 1,4-dichlorobenzenes.
Chemico-biological interactions 1992;84(3):259-75.
1992: Bogaards J J; van Ommen B; van Bladeren P J
Purification and characterization of eight glutathione S-transferase isoenzymes of hamster. Comparison of subunit composition of enzymes from liver, kidney, testis, pancreas and trachea.
The Biochemical journal 1992;286 ( Pt 2)():383-8.
1992: Wortelboer H M; van der Linden E C; de Kruif C A; Noordhoek J; Blaauboer B J; van Bladeren P J; Falke H E
Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(7):589-99.
1992: Groten J P; Luten J B; van Bladeren P J
Dietary iron lowers the intestinal uptake of cadmium-metallothionein in rats.
European journal of pharmacology 1992;228(1):23-8.
1992: Willems M I; Dubois G; Boyd D R; Davies R J; Hamilton L; McCullough J J; van Bladeren P J
Comparison of the mutagenicity of quinoline and all monohydroxyquinolines with a series of arene oxide, trans-dihydrodiol, diol epoxide, N-oxide and arene hydrate derivatives of quinoline in the Ames/Salmonella microsome test.
Mutation research 1992;278(4):227-36.
1992: Wortelboer H M; de Kruif C A; van Iersel A A; Noordhoek J; Blaauboer B J; van Bladeren P J; Falke H E
Effects of cooked brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(1):17-27.
1992: Groten J P; Hissink E; van Bladeren P J
Differences in chromatographic behaviour of rat and pig metallothionein isoforms: a possible method of distinguishing between exogenous and endogenous metallothioneins.
IARC scientific publications 1992;(118):219-24.
1991: Groten J P; Sinkeldam E J; Luten J B; van Bladeren P J
Cadmium accumulation and metallothionein concentrations after 4-week dietary exposure to cadmium chloride or cadmium-metallothionein in rats.
Toxicology and applied pharmacology 1991;111(3):504-13.
1991: den Besten C; Vet J J; Besselink H T; Kiel G S; van Berkel B J; Beems R; van Bladeren P J
The liver, kidney, and thyroid toxicity of chlorinated benzenes.
Toxicology and applied pharmacology 1991;111(1):69-81.
1991: Mertens J J; Temmink J H; van Bladeren P J; Jones T W; Lo H H; Lau S S; Monks T J
Inhibition of gamma-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones.
Toxicology and applied pharmacology 1991;110(1):45-60.
1991: van Ommen B; Ploemen J H; Bogaards J J; Monks T J; Gau S S; van Bladeren P J
Irreversible inhibition of rat glutathione S-transferase 1-1 by quinones and their glutathione conjugates. Structure-activity relationship and mechanism.
The Biochemical journal 1991;276 ( Pt 3)():661-6.
1991: Ploemen J H; van Ommen B; van Bladeren P J
Irreversible inhibition of human glutathione S-transferase isoenzymes by tetrachloro-1,4-benzoquinone and its glutathione conjugate.
Biochemical pharmacology 1991;41(11):1665-9.
1991: Groten J P; Sinkeldam E J; Muys T; Luten J B; van Bladeren P J
Interaction of dietary Ca, P, Mg, Mn, Cu, Fe, Zn and Se with the accumulation and oral toxicity of cadmium in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1991;29(4):249-58.
1991: den Besten C; Smink M C; de Vries E J; van Bladeren P J
Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: a major role for quinone metabolites.
Toxicology and applied pharmacology 1991;108(2):223-33.
1991: Peters M M; Walters D G; van Ommen B; van Bladeren P J; Lake B G
Effect of inducers of cytochrome P-450 on the metabolism of [3-14C]coumarin by rat hepatic microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(4):499-514.
1991: Feron V J; Til H P; de Vrijer F; Woutersen R A; Cassee F R; van Bladeren P J
Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment.
Mutation research 1991;259(3-4):363-85.
1991: van Ommen B; Bogaards J J; Ploemen J P; van der Greef J; van Bladeren P J
Quinones and their glutathione conjugates as irreversible inhibitors of glutathione S-transferases.
Advances in experimental medicine and biology 1991;283():403-6.
1991: Vos R M; van Welie R T; Peters W H; Evelo C T; Boogaards J J; Vermeulen N P; van Bladeren P J
Genetic deficiency of human class mu glutathione S-transferase isoenzymes in relation to the urinary excretion of the mercapturic acids of Z- and E-1,3-dichloropropene.
Archives of toxicology 1991;65(2):95-9.
1991: Monks T J; Lau S S; Mertens J J; Temmink J H; van Bladeren P J
The nephrotoxicity of 2,5-dichloro-3-(glutathion-S-yl)-1,4-benzoquinone, and 2,5,6-trichloro-3-(glutathion-S-yl)-1,4-benzoquinone is potentiated by ascorbic acid and AT-125.
Advances in experimental medicine and biology 1991;283():767-9.
1990: Feron V J; van Bladeren P J; Hermus R J
A viewpoint on the extrapolation of toxicological data from animals to man.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1990;28(11):783-8.
1990: Monks T J; Anders M W; Dekant W; Stevens J L; Lau S S; van Bladeren P J
Glutathione conjugate mediated toxicities.
Toxicology and applied pharmacology 1990;106(1):1-19.
1990: Ploemen J H; van Ommen B; van Bladeren P J
Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate.
Biochemical pharmacology 1990;40(7):1631-5.
1990: Jonker D; Woutersen R A; van Bladeren P J; Til H P; Feron V J
4-week oral toxicity study of a combination of eight chemicals in rats: comparison with the toxicity of the individual compounds.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1990;28(9):623-31.
1990: Bruggeman I M; Van Bladeren P J; Temmink J H
Transport and toxicity of CdCl2 in LLC-PK1 cells.
Toxicology letters 1990;53(1-2):167-8.
1990: Mertens J J; Sterck J G; Lau S S; Monks T J; van Bladeren P J; Temmink J H
Cytotoxicity of nephrotoxic glutathione-conjugated halohydroquinones.
Toxicology letters 1990;53(1-2):147-9.
1990: van Ommen B; Bogaards J J; Peters W H; Blaauboer B; van Bladeren P J
Quantification of human hepatic glutathione S-transferases.
The Biochemical journal 1990;269(3):609-13.
1990: Groten J P; Sinkeldam E J; Luten J B; van Bladeren P J
Comparison of the toxicity of inorganic and liver-incorporated cadmium: a 4-wk feeding study in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1990;28(6):435-41.
1990: Bogaards J J; van Ommen B; Falke H E; Willems M I; van Bladeren P J
Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1990;28(2):81-8.
1990: Mertens J J; Keukens E A; Appel M; Spenkelink B; Temmink J H; van Bladeren P J
Cytotoxicity of S-(1,2,3,4,4-pentachlorobutadienyl)-L cysteine after apical and basolateral exposure of LLC-PK monolayers. Involvement of an amino acid transport system.
Chemico-biological interactions 1990;75(1):119-30.
1990: Vos R M; Van Bladeren P J
Glutathione S-transferases in relation to their role in the biotransformation of xenobiotics.
Chemico-biological interactions 1990;75(3):241-65.
1990: Vroomen L H; Berghmans M C; van Bladeren P J; Groten J P; Wissink C J; Kuiper H A
In vivo and in vitro metabolic studies of furazolidone: a risk evaluation.
Drug metabolism reviews 1990;22(6-8):663-76.
1989: van Ommen B; Hendriks W; Bessems J G; Geesink G; Müller F; van Bladeren P J
The relation between the oxidative biotransformation of hexachlorobenzene and its porphyrinogenic activity.
Toxicology and applied pharmacology 1989;100(3):517-28.
1989: den Besten C; Peters M M; van Bladeren P J
The metabolism of pentachlorobenzene by rat liver microsomes: the nature of the reactive intermediates formed.
Biochemical and biophysical research communications 1989;163(3):1275-81.
1989: Bogaards J J; van Ommen B; van Bladeren P J
An improved method for the separation and quantification of glutathione S-transferase subunits in rat tissue using high-performance liquid chromatography.
Journal of chromatography 1989;474(2):435-40.
1989: van Ommen B; Ploemen J H; Ruven H J; Vos R M; Bogaards J J; van Berkel W J; van Bladeren P J
Studies on the active site of rat glutathione S-transferase isoenzyme 4-4. Chemical modification by tetrachloro-1,4-benzoquinone and its glutathione conjugate.
European journal of biochemistry / FEBS 1989;181(2):423-9.
1989: Vos R M; Rietjens I M; Stevens L H; Van Bladeren P J
Methyl linoleate ozonide as a substrate for rat glutathione S-transferases: reaction pathway and isoenzyme selectivity.
Chemico-biological interactions 1989;69(2-3):269-78.
1989: van Ommen B; van Bladeren P J
Possible reactive intermediates in the oxidative biotransformation of hexachlorobenzene.
Drug metabolism and drug interactions 1989;7(2-3):213-43.
1989: Vos R M; Van Ommen B; Hoekstein M S; De Goede J H; Van Bladeren P J
Irreversible inhibition of rat hepatic glutathione S-transferase isoenzymes by a series of structurally related quinones.
Chemico-biological interactions 1989;71(4):381-92.
1988: Jongen W M; Sandker G W; Goertz M P; Topp R J; van Bladeren P J
Modulating effects of beta-naphthoflavone on the induction of SCEs by model compounds with emphasis on benzo[a]pyrene.
Mutation research 1988;202(1):155-61.
1988: van Ommen B; den Besten C; Rutten A L; Ploemen J H; Vos R M; Müller F; van Bladeren P J
Active site-directed irreversible inhibition of glutathione S-transferases by the glutathione conjugate of tetrachloro-1,4-benzoquinone.
The Journal of biological chemistry 1988;263(26):12939-42.
1988: Vroomen L H; Berghmans M C; Groten J P; Koeman J H; van Bladeren P J
Reversible interaction of a reactive intermediate derived from furazolidone with glutathione and protein.
Toxicology and applied pharmacology 1988;95(1):53-60.
1988: Vos R M; Snoek M C; van Berkel W J; Müller F; van Bladeren P J
Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene.
Biochemical pharmacology 1988;37(6):1077-82.
1988: Mertens J J; Weijnen J G; van Doorn W J; Spenkelink B; Temmink J H; van Bladeren P J
Differential toxicity as a result of apical and basolateral treatment of LLC-PK1 monolayers with S-(1,2,3,4,4-pentachlorobutadienyl)glutathione and N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine.
Chemico-biological interactions 1988;65(3):283-93.
1988: van Ommen B; Voncken J W; Müller F; van Bladeren P J
The oxidation of tetrachloro-1,4-hydroquinone by microsomes and purified cytochrome P-450b. Implications for covalent binding to protein and involvement of reactive oxygen species.
Chemico-biological interactions 1988;65(3):247-59.
1987: Vos R M; Rietjens I M; Alink G M; van Bladeren P J
Methyl linoleate ozonide: a substrate for rat glutathione S-transferases.
European journal of drug metabolism and pharmacokinetics 1987;12(4):275-7.
1987: Vroomen L H; Groten J P; van Muiswinkel K; van Velduizen A; van Bladeren P J
Identification of a reactive intermediate of furazolidone formed by swine liver microsomes.
Chemico-biological interactions 1987;64(1-2):167-79.
1986: Temmink J H; Bruggeman I M; van Bladeren P J
Cytomorphological changes in liver cells exposed to allyl and benzyl isothiocyanate and their cysteine and glutathione conjugates.
Archives of toxicology 1986;59(2):103-10.
1986: Bruggeman I M; Temmink J H; van Bladeren P J
Glutathione- and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate.
Toxicology and applied pharmacology 1986;83(2):349-59.

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