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Richard Van Breemen

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Kasim K. Kabirov; Izet M Kapetanovic; Aryamitra Banerjee; Doris M Benbrook; Lian Chen; Carol J Detrisac; Nancy Dinger; Irina Mankovskaya; Tomás Martín-Jiménez; Dejan Nikolic; Emmanuel Onua; Marcia Pereira; Richard B Van Breemen; Alexander Zakharov; Aleksander V. Lyubimov
Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs.
Richard B Van Breemen
Robert j. Cotter (1943-2012).
Ron Gaba; Grace Guzman-Hartman; Yongchao Li; Elizabeth M Martinez; Ahmad Parvinian; Richard B Van Breemen; Felix Y Yap; Nishant Kumar
Transarterial sorafenib chemoembolization: preliminary study of technical feasibility in a rabbit model.

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2013: Kasim K. Kabirov; Izet M Kapetanovic; Aryamitra Banerjee; Doris M Benbrook; Lian Chen; Carol J Detrisac; Nancy Dinger; Irina Mankovskaya; Tomás Martín-Jiménez; Dejan Nikolic; Emmanuel Onua; Marcia Pereira; Richard B Van Breemen; Alexander Zakharov; Aleksander V. Lyubimov
Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs.
Drug and chemical toxicology 2013;36(3):284-95.
2013: Richard B Van Breemen
Robert j. Cotter (1943-2012).
Journal of the American Society for Mass Spectrometry 2013;24(5):655-6.
2013: Ron Gaba; Grace Guzman-Hartman; Yongchao Li; Elizabeth M Martinez; Ahmad Parvinian; Richard B Van Breemen; Felix Y Yap; Nishant Kumar
Transarterial sorafenib chemoembolization: preliminary study of technical feasibility in a rabbit model.
Journal of vascular and interventional radiology : JVIR 2013;24(5):744-50.
2013: Xi Qiu; Michael A Tessel; Avani Vaishnav; Larisa Nonn; Yang Yuan; Richard B Van Breemen
Effects of lycopene on protein expression in human primary prostatic epithelial cells.
Cancer prevention research (Philadelphia, Pa.) 2013;6(5):419-27.
2013: Martin Conda-Sheridan; Daniel E Beck; Lian Chen; Bingjie Hu; Trung X Nguyen; Eun-Jung Park; John M Pezzuto; P V Narasimha Reddy; Richard B Van Breemen; Jerry J White; Mark Cushman
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.
Journal of medicinal chemistry 2013;56(6):2581-605.
2013: Rui Yu; Guiqing Zhao; John W Christman; Lei Xiao; Richard B Van Breemen
Method development and validation for ultra-high pressure liquid chromatography/tandem mass spectrometry determination of multiple prostanoids in biological samples.
Journal of AOAC International 2013;96(1):67-76.
2013: Yang Yuan; Li-Fang Yu; Alan P Kozikowski; Xi Qiu; Richard B Van Breemen
Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective α4β2-nAChR partial agonist and promising antidepressant.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2013;912():38-42.
2013: Guiqing Zhao; Qiong Zhao; Rui Yu; John W Christman; Jing Deng; Myungsoo Joo; Yongchao Li; Richard B Van Breemen; Lei Xiao
Pivotal role of reactive oxygen species in differential regulation of lipopolysaccharide-induced prostaglandins production in macrophages.
Molecular pharmacology 2013;83(1):167-78.
2012: Shi-Hui Dong; Dejan Nikolic; Guido F Pauli; Feng Qiu; Charlotte Simmler; Djaja D Soejarto; Richard B Van Breemen; Shao-Nong Chen
Diarylheptanoids from Dioscorea villosa (Wild Yam).
Journal of natural products 2012;75(12):2168-77.
2012: Maris A Cinelli; Keli Agama; Lian Chen; Jian-Hua Liang; Peng-Cheng Lv; Yves Pommier; P V Narasimha Reddy; Richard B Van Breemen; Mark Cushman
Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poisons.
Journal of medicinal chemistry 2012;55(24):10844-62.
2012: Sigrid Baumgarten; Ron Gaba; Richard B Van Breemen
Confirmation of drug delivery after liver chemoembolization: direct tissue doxorubicin measurement by UHPLC-MS-MS.
Biomedical chromatography : BMC 2012;26(12):1529-33.
2012: Yang Yuan; Jeffrey H Dahl; Dejan Nikolic; Xi Qiu; Richard B Van Breemen
Method development and validation for ultra-high-pressure LC/MS/MS determination of hop prenylflavonoids in human serum.
Journal of AOAC International 2012;95(6):1744-9.
2012: Aditya Sudheer Vaidya; Richard B Van Breemen; Hazem Abdelkarim; He Bai; Sylvie Y Blond; Antonett Madriaga; Emma Mendonca; Raghupathi Neelarapu; Pavel A Petukhov
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.
Bioorganic & medicinal chemistry letters 2012;22(21):6621-7.
2012: Aditya Sudheer Vaidya; Richard B Van Breemen; Hazem Abdelkarim; Bhargava Karumudi; Antonett Madriaga; Emma Mendonca; Pavel A Petukhov
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.
Bioorganic & medicinal chemistry letters 2012;22(15):5025-30.
2012: Hongling Zhu; Aurora Lopez-Rosas; Xi Qiu; Richard B Van Breemen; Ernesto R Bongarzone
Detection of the neurotoxin psychosine in samples of peripheral blood: application in diagnostics and follow-up of Krabbe disease.
Archives of pathology & laboratory medicine 2012;136(7):709-10.
2012: Lian Chen; Martin Conda-Sheridan; Tamara P Kondratyuk; Andrew Morrell; Eun-Jung Park; John M Pezzuto; P V Narasimha Reddy; Richard B Van Breemen; Mark Cushman
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.
Journal of medicinal chemistry 2012;55(12):5965-81.
2012: Dejan Nikolić; Guido F Pauli; Shao-Nong Chen; Tanja Gödecke; David C Lankin; Jerry White; Richard B Van Breemen
Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.).
Fitoterapia 2012;83(3):441-60.
2012: Umaima Al-Alem; Jeffrey Dahl; Mark D Evans; Peter H Gann; Patricia M W Lam; Vilas Mistry; Richard B Van Breemen; Linda Van Horn; Margaret E. Wright
Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women.
Genes & nutrition 2012;7(2):191-5.
2012: Tamara P Kondratyuk; Brian Thatcher Murphy; Eun-Jung Park; Ratnakar N Asolkar; William Fenical; Richard B Van Breemen; Rui Yu; John M Pezzuto
Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents.
Marine drugs 2012;10(2):451-64.
2012: Ron Gaba; Kelly D Garcia; Andrew C Larson; Benedictta O Omene; Sigrid Baumgarten; Richard B Van Breemen; Reed A Omary
Ethiodized oil uptake does not predict doxorubicin drug delivery after chemoembolization in VX2 liver tumors.
Journal of vascular and interventional radiology : JVIR 2012;23(2):265-73.
2012: Chenqi Hu; Andrew D Mesecar; Dejan Nikolic; Aimee L Eggler; Richard B Van Breemen
Screening for natural chemoprevention agents that modify human Keap1.
Analytical biochemistry 2012;421(1):108-14.
2012: Tanja Goedecke; José G Napolitano; Ping Yao; Birgit M Dietz; David C Lankin; Dejan Nikolić; Richard B Van Breemen; Norman R Farnsworth; Judy L Bolton; Shao-Nong Chen; Guido F Pauli
Integrated standardization concept for Angelica botanicals using quantitative NMR.
Fitoterapia 2012;83(1):18-32.
2011: Rui Yu; Guiqing Zhao; John W Christman; Lei Xiao; Richard B Van Breemen
Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2.
The Journal of pharmacology and experimental therapeutics 2011;339(2):716-25.
2011: Tamara P Kondratyuk; Laura E Marler; Andrew D Mesecar; Eun-Jung Park; Soyoun Ahn; Yongsoo Choi; Mark Cushman; Clinton J Grubbs; Juma Hoshino; Katherine C Jermihov; Bin Sun; Richard B Van Breemen; Rui Yu; Yang Yuan; John M Pezzuto
Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity.
Molecular nutrition & food research 2011;55(8):1249-65.
2011: Ludovico Cantuti Castelvetri; Maria I Givogri; Aurora Lopez-Rosas; Xi Qiu; Benjamin Smith; Richard B Van Breemen; Hongling Zhu; Ernesto R Bongarzone
Axonopathy is a compounding factor in the pathogenesis of Krabbe disease.
Acta neuropathologica 2011;122(1):35-48.
2011: Shaonong Chen; John Brent Friesen; Donna Webster; Dejan Nikolic; Richard B Van Breemen; Zaijie Jim Wang; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Phytoconstituents from Vitex agnus-castus fruits.
Fitoterapia 2011;82(4):528-33.
2011: Richard B Van Breemen; Roohollah Sharifi; Marlos Viana; Natasa Pajkovic; Dongwei Zhu; Long Yuan; Yanan Yang; Phyllis E Bowen; Maria Stacewicz-Sapuntzakis
Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: a randomized, controlled trial.
Cancer prevention research (Philadelphia, Pa.) 2011;4(5):711-8.
2011: Chenqi Hu; Aimee L Eggler; Andrew D Mesecar; Richard B Van Breemen
Modification of keap1 cysteine residues by sulforaphane.
Chemical research in toxicology 2011;24(4):515-21.
2011: Eun-Jung Park; Tamara P Kondratyuk; Andrew Morrell; Evgeny Kiselev; Martin Conda-Sheridan; Mark Cushman; Soyoun Ahn; Yongsoo Choi; Jerry J White; Richard B Van Breemen; John M Pezzuto
Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells.
Cancer prevention research (Philadelphia, Pa.) 2011;4(4):592-607.
2011: A B White; Francesca Galbiati; Maria I Givogri; A Lopez Rosas; X Qiu; Richard B Van Breemen; Ernesto R Bongarzone
Persistence of psychosine in brain lipid rafts is a limiting factor in the therapeutic recovery of a mouse model for Krabbe disease.
Journal of neuroscience research 2011;89(3):352-64.
2011: Jian-Hong Yang; Tamara P Kondratyuk; Katherine C Jermihov; Laura E Marler; Xi Qiu; Yongsoo Choi; Hongmei Cao; Rui Yu; Megan Sturdy; Rong Huang; Ying Liu; Li-Qin Wang; Andrew D Mesecar; Richard B Van Breemen; John M Pezzuto; Harry H S Fong; Ye-Gao Chen; Hong-Jie Zhang
Bioactive compounds from the fern Lepisorus contortus.
Journal of natural products 2011;74(2):129-36.
2011: Yongsoo Choi; Katherine Jermihov; Sang-Jip Nam; Megan Sturdy; Katherine Maloney; Xi Qiu; Lucas R Chadwick; Matthew Main; Shaonong Chen; Andrew D Mesecar; Norman R Farnsworth; Guido F Pauli; William Fenical; John M Pezzuto; Richard B van Breemen; Richard B Van Breemen
Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS.
Analytical chemistry 2011;83(3):1048-52.
2011: Hongmei Cao; Rui Yu; Yi Tao; Dejan Nikolic; Richard B Van Breemen
Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2011;54(1):230-5.
2011: Richard B Van Breemen; Yi Tao; Wenkui Li
Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale).
Fitoterapia 2011;82(1):38-43.
2010: Laura Marler; Martin Conda-Sheridan; Maris A Cinelli; Andrew E Morrell; Mark Cushman; Lian Chen; Ke Huang; Richard B Van Breemen; John M Pezzuto
Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives.
Anticancer research 2010;30(12):4873-82.
2010: Jeffrey H Dahl; Richard B Van Breemen
Rapid quantitative analysis of 8-iso-prostaglandin-F(2alpha) using liquid chromatography-tandem mass spectrometry and comparison with an enzyme immunoassay method.
Analytical biochemistry 2010;404(2):211-6.
2010: Zhican Wang; Ranepuradewage Chandrasena; Yang Yuan; Kuan-Wei Peng; Richard B Van Breemen; Gregory R J Thatcher; Judy L Bolton
Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens.
Chemical research in toxicology 2010;23(8):1365-73.
2010: Juma Hoshino; Eun-Jung Park; Tamara P Kondratyuk; Laura Marler; John M Pezzuto; Richard B Van Breemen; Shunyan Mo; Yongchao Li; Mark Cushman
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.
Journal of medicinal chemistry 2010;53(13):5033-43.
2010: Jian Guo; Dacheng Peng; Qing Dai; Shutsung Liao; Brian J Wright; Richard B Van Breemen
Quantitative analysis of 3alpha,6alpha,24-trihydroxy-24,24-di(trifluoromethyl)-5beta-cholane, a potent synthetic steroidal liver X receptor agonist in plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(21):1885-8.
2010: Selin Bolca; Jinghu Li; Dejan Nikolic; Nathalie Roche; Phillip Blondeel; Sam Possemiers; Denis De Keukeleire; Marc Bracke; Arne Heyerick; Richard B Van Breemen; Herman Depypere
Disposition of hop prenylflavonoids in human breast tissue.
Molecular nutrition & food research 2010;54 Suppl 2():S284-94.
2010: Hongmei Cao; Rui Yu; Yongsoo Choi; Zhong-Ze Ma; Hongjie Zhang; Wei Xiang; David Yue-Wei Lee; Brian Berman; Kamal D Moudgil; Harry H S Fong; Richard B Van Breemen
Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;61(6):519-24.
2010: Carolien A Van Loo-Bouwman; Ton H J Naber; Richard B Van Breemen; Dongwei Zhu; Heleen Dicke; Els Siebelink; Paul J M Hulshof; Frans G M Russel; Gertjan Schaafsma; Clive E West
Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique.
The British journal of nutrition 2010;103(12):1836-43.
2010: Jian-Hong Yang; Tamara P Kondratyuk; Laura E Marler; Xi Qiu; Yongsoo Choi; Hongmei Cao; Rui Yu; Megan Sturdy; Scott Pegan; Ying Liu; Li-Qin Wang; Andrew D Mesecar; Richard B Van Breemen; John M Pezzuto; Harry H S Fong; Ye-Gao Chen; Hong-Jie Zhang
Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata.
Phytochemistry 2010;71(5-6):641-7.
2010: Muriel Cuendet; Jian Guo; Yan Luo; Shaonong Chen; Carol P Oteham; Richard C Moon; Richard B Van Breemen; Laura E Marler; John M Pezzuto
Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice.
Cancer prevention research (Philadelphia, Pa.) 2010;3(2):221-32.
2010: Richard B Van Breemen; W Liang; Suzanne Banuvar; Lee P Shulman; Y Pang; Y Tao; Dejan Nikolic; K M Krock; Daniel S Fabricant; Shaonong Chen; Samad Hedayat; Judy L Bolton; Guido F Pauli; Colleen E Piersen; E C Krause; Stacie E Geller; Norman R Farnsworth
Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh.
Clinical pharmacology and therapeutics 2010;87(2):219-25.
2009: Bai He; Subash Velaparthi; Gilles Pieffet; Chris Pennington; Aruna Mahesh; Denise L Holzle; Michael Brunsteiner; Richard B Van Breemen; Sylvie Blond; Pavel A Petukhov
Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors.
Journal of medicinal chemistry 2009;52(22):7003-13.
2009: Jialin Mao; Hai Yuan; Yuehong Wang; Baojie Wan; Marco Pieroni; Qingqing Huang; Richard B Van Breemen; Alan P Kozikowski; Scott Franzblau
From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters.
Journal of medicinal chemistry 2009;52(22):6966-78.
2009: Yi Tao; Wenkui Li; Wenzhong Liang; Richard B Van Breemen
Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry.
Journal of agricultural and food chemistry 2009;57(21):10014-21.
2009: Stacie E Geller; Lee P Shulman; Richard B Van Breemen; Suzanne Banuvar; Ying Zhou; Geena Epstein; Samad Hedayat; Dejan Nikolic; Elizabeth C Krause; Colleen E Piersen; Judy L Bolton; Guido F Pauli; Norman R Farnsworth
Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.
Menopause (New York, N.Y.) 2009;16(6):1156-66.
2009: Angela I Calderón; Brian J Wright; W Jeffrey Hurst; Richard B Van Breemen
Screening antioxidants using LC-MS: case study with cocoa.
Journal of agricultural and food chemistry 2009;57(13):5693-9.
2009: Francesca Galbiati; Maria I Givogri; L Cantuti; A Lopez Rosas; Hongmei Cao; Richard B Van Breemen; Ernesto R Bongarzone
Combined hematopoietic and lentiviral gene-transfer therapies in newborn Twitcher mice reveal contemporaneous neurodegeneration and demyelination in Krabbe disease.
Journal of neuroscience research 2009;87(8):1748-59.
2009: Carolien A Van Loo-Bouwman; Clive E West; Richard B Van Breemen; Dongwei Zhu; Els Siebelink; Pieter Versloot; Paul J M Hulshof; Machteld van Lieshout; Frans G M Russel; Gertjan Schaafsma; Ton H J Naber
Vitamin A equivalency of beta-carotene in healthy adults: limitation of the extrinsic dual-isotope dilution technique to measure matrix effect.
The British journal of nutrition 2009;101(12):1837-45.
2009: Adam B White; Maria I Givogri; Aurora Lopez-Rosas; Hongmei Cao; Richard B Van Breemen; Gopal Thinakaran; Ernesto R Bongarzone
Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(19):6068-77.
2009: Tanja Gödecke; David C Lankin; Dejan Nikolic; Shaonong Chen; Richard B Van Breemen; Norman R Farnsworth; Guido F Pauli
Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).
Journal of natural products 2009;72(3):433-7.
2009: Zhican Wang; Gihani Wijewickrama; Kuan-Wei Peng; Birgit M Dietz; Long Yuan; Richard B Van Breemen; Judy L Bolton; Gregory R J Thatcher
Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus.
The Journal of biological chemistry 2009;284(13):8633-42.
2009: Tanja Gödecke; Dejan Nikolic; David C Lankin; Shaonong Chen; Sharla L Powell; Birgit M Dietz; Judy L Bolton; Richard B Van Breemen; Norman R Farnsworth; Guido F Pauli
Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts.
Phytochemical analysis : PCA 2009;20(2):120-33.
2009: Zhihui Qin; Irida Kastrati; Rezene T Ashgodom; Daniel D Lantvit; Cassia R Overk; Yongsoo Choi; Richard B Van Breemen; Judy L Bolton; Gregory R J Thatcher
Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(1):161-9.
2008: Sharla L Powell; Tanja Gödecke; Dejan Nikolic; Shaonong Chen; Soyoun Ahn; Birgit M Dietz; Norman R Farnsworth; Richard B Van Breemen; David C Lankin; Guido F Pauli; Judy L Bolton
In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent.
Journal of agricultural and food chemistry 2008;56(24):11718-26.
2008: Cassia R Overk; Jian Guo; Lucas R Chadwick; Daniel D Lantvit; Alberto Minassi; Giovanni Appendino; Shaonong Chen; David C Lankin; Norman R Farnsworth; Guido F Pauli; Richard B Van Breemen; Judy L Bolton
In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.
Chemico-biological interactions 2008;176(1):30-9.
2008: Richard B Van Breemen; Natasa Pajkovic
Multitargeted therapy of cancer by lycopene.
Cancer letters 2008;269(2):339-51.
2008: Birgit M Dietz; Dongting Liu; Ghenet Hagos; Ping Yao; Andreas Schinkovitz; Samuel M Pro; Shixin Deng; Norman R Farnsworth; Guido F Pauli; Richard B Van Breemen; Judy L Bolton
Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.
Chemical research in toxicology 2008;21(10):1939-48.
2008: Jian Guo; Ang Liu; Hongmei Cao; Yan Luo; John M Pezzuto; Richard B Van Breemen
Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2104-12.
2008: Shuang Ding; Yan Wang; Alexander Kolbanovskiy; Alexander Durandin; Judy L Bolton; Richard B Van Breemen; Suse Broyde; Nicholas E Geacintov
Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry.
Chemical research in toxicology 2008;21(9):1739-48.
2008: Shaonong Chen; Allison Turner; Birgit U Jaki; Dejan Nikolic; Richard B Van Breemen; John Brent Friesen; Guido F Pauli
An experimental implementation of chemical subtraction.
Journal of pharmaceutical and biomedical analysis 2008;46(4):692-8.
2008: Richard B Van Breemen; Harry H S Fong; Norman R Farnsworth
Ensuring the safety of botanical dietary supplements.
The American journal of clinical nutrition 2008;87(2):509S-13S.
2008: Norman R Farnsworth; Elizabeth C Krause; Judy L Bolton; Guido F Pauli; Richard B Van Breemen; James G Graham
The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use.
The American journal of clinical nutrition 2008;87(2):504S-8S.
2008: Stephen Barnes; Diane F Birt; Barrie R Cassileth; William T Cefalu; Floyd H Chilton; Norman R Farnsworth; Ilya Raskin; Richard B Van Breemen; Connie M Weaver
Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers.
The American journal of clinical nutrition 2008;87(2):476S-80S.
2008: Jian Guo; Dongting Liu; Dejan Nikolic; Dongwei Zhu; John M Pezzuto; Richard B Van Breemen
In vitro metabolism of isoliquiritigenin by human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):461-8.
2008: Yongsoo Choi; Richard B Van Breemen
Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS.
Combinatorial chemistry & high throughput screening 2008;11(1):1-6.
2008: Hongmei Cao; Lei Xiao; Gyeyoung Park; Xuerong Wang; anser azim; John W Christman; Richard B Van Breemen
An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids.
Analytical biochemistry 2008;372(1):41-51.
2007: Dongting Liu; Jian Guo; Yan Luo; David Broderick; Michael I Schimerlik; John M Pezzuto; Richard B Van Breemen
Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry.
Analytical chemistry 2007;79(24):9398-402.
2007: Francesca Galbiati; Veronica Basso; Ludovico Cantuti; Maria I Givogri; Aurora Lopez-Rosas; Nicolas Perez; Chenthamarakshan Vasu; Hongmei Cao; Richard B Van Breemen; Anna Mondino; Ernesto R Bongarzone
Autonomic denervation of lymphoid organs leads to epigenetic immune atrophy in a mouse model of Krabbe disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(50):13730-8.
2007: anser azim; Xuerong Wang; Gye Young Parkgy; Ruxana T Sadikot; Hongmei Cao; Biji Mathew; Michael Atchison; Richard B Van Breemen; Myungsoo Joo; John W Christman
NF-kappaB-inducing kinase regulates cyclooxygenase 2 gene expression in macrophages by phosphorylation of PU.1.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7868-75.
2007: Yan Luo; Aimee L Eggler; Dongting Liu; Guowen Liu; Andrew D Mesecar; Richard B Van Breemen
Sites of alkylation of human Keap1 by natural chemoprevention agents.
Journal of the American Society for Mass Spectrometry 2007;18(12):2226-32.
2007: Aimee L Eggler; Yan Luo; Richard B Van Breemen; Andrew D Mesecar
Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.
Chemical research in toxicology 2007;20(12):1878-84.
2007: anser azim; Hongmei Cao; Xiao-Pei Gao; Myungsoo Joo; Asrar B Malik; Richard B Van Breemen; Ruxana T Sadikot; Gyeyoung Park; John W Christman
Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages.
American journal of physiology. Lung cellular and molecular physiology 2007;293(3):L668-73.
2007: Yan Pang; Dejan Nikolic; Dongwei Zhu; Lucas R Chadwick; Guido F Pauli; Norman R Farnsworth; Richard B Van Breemen
Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells.
Molecular nutrition & food research 2007;51(7):872-9.
2007: Shaonong Chen; David C Lankin; Dejan Nikolic; Daniel S Fabricant; Zhi-Zhen Lu; Benjamin Ramirez; Richard B Van Breemen; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Chlorination diversifies Cimicifuga racemosa triterpene glycosides.
Journal of natural products 2007;70(6):1016-23.
2007: Biji Mathew; Gye Young Parkgy; Hongmei Cao; anser azim; Xuerong Wang; Richard B Van Breemen; Ruxana T Sadikot; John W Christman
Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages.
American journal of respiratory cell and molecular biology 2007;36(5):562-72.
2007: Richard B Van Breemen; Harry H S Fong; Norman R Farnsworth
The role of quality assurance and standardization in the safety of botanical dietary supplements.
Chemical research in toxicology 2007;20(4):577-82.
2007: Wenkui Li; Xudong Xu; Hong-Jie Zhang; Cuiying Ma; Harry H S Fong; Richard B Van Breemen; John F Fitzloff
Secondary metabolites from Andrographis paniculata.
Chemical & pharmaceutical bulletin 2007;55(3):455-8.
2007: Allison Turner; Shaonong Chen; Dejan Nikolic; Richard B Van Breemen; Norman R Farnsworth; Guido F Pauli
Coumaroyl iridoids and a depside from cranberry (Vaccinium macrocarpon).
Journal of natural products 2007;70(2):253-8.
2006: Zhiyong Wang; Hai Yuan; Dejan Nikolic; Richard B Van Breemen; Richard B Silverman
(+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway.
Biochemistry 2006;45(48):14513-22.
2006: Izet M Kapetanovic; R Krishnaraj; T Martin-Jimenez; L Yuan; Richard B Van Breemen; Aleksander V. Lyubimov
Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics.
Chemico-biological interactions 2006;164(1-2):68-75.
2006: Shixin Deng; Shaonong Chen; Jian Lu; Zaijie Jim Wang; Dejan Nikolic; Richard B Van Breemen; Bernard D Santarsiero; Andrew D Mesecar; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.
Phytochemical analysis : PCA 2006;17(6):398-405.
2006: Ang Liu; Natasa Pajkovic; Yan Pang; Dongwei Zhu; Barbara Calamini; Andrew D Mesecar; Richard B Van Breemen
Absorption and subcellular localization of lycopene in human prostate cancer cells.
Molecular cancer therapeutics 2006;5(11):2879-85.
2006: Alida Melse-Boonstra; Petra Verhoef; Clive E West; Johannes A van Rhijn; Richard B Van Breemen; Johan J P Lasaroms; Spiros D Garbis; Martijn B Katan; Frans J Kok
A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses.
The American journal of clinical nutrition 2006;84(5):1128-33.
2006: Jian Guo; Dejan Nikolic; Lucas R Chadwick; Guido F Pauli; Richard B Van Breemen
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1152-9.
2006: Dejan Nikolic; Yongmei Li; Lucas R Chadwick; Richard B Van Breemen
In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.).
Pharmaceutical research 2006;23(5):864-72.
2006: Uppuluri V Mallavadhani; Kilambi Narasimhan; Akella Venkata Subrahmanya Sudhakar; Anita Mahapatra; Wenkui Li; Richard B Van Breemen
Three new pentacyclic triterpenes and some flavonoids from the fruits of an Indian Ayurvedic plant Dendrophthoe falcata and their estrogen receptor binding activity.
Chemical & pharmaceutical bulletin 2006;54(5):740-4.
2006: Shixin Deng; Shaonong Chen; Ping Yao; Dejan Nikolic; Richard B Van Breemen; Judy L Bolton; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis.
Journal of natural products 2006;69(4):536-41.
2006: Nancy Booth; Cassia R Overk; Ping Yao; Joanna E Burdette; Dejan Nikolic; Shaonong Chen; Judy L Bolton; Richard B Van Breemen; Guido F Pauli; Norman R Farnsworth
The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract.
Journal of alternative and complementary medicine (New York, N.Y.) 2006;12(2):133-9.
2006: Dongwei Zhu; Yan Wang; Yan Pang; Ang Liu; Jian Guo; Carolien A Bouwman; Clive E West; Richard B Van Breemen
Quantitative analyses of beta-carotene and retinol in serum and feces in support of clinical bioavailability studies.
Rapid communications in mass spectrometry : RCM 2006;20(16):2427-32.
2005: Yan Li; Xiaofeng Yang; Richard B Van Breemen; Judy L Bolton
Characterization of two new variants of human catechol O-methyltransferase in vitro.
Cancer letters 2005;230(1):81-9.
2005: Xun Cheng; Richard B Van Breemen
Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation.
Analytical chemistry 2005;77(21):7012-5.
2005: Guowen Liu; Aimee L Eggler; Birgit M Dietz; Andrew D Mesecar; Judy L Bolton; John M Pezzuto; Richard B Van Breemen
Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.
Analytical chemistry 2005;77(19):6407-14.
2005: Jianhua Liu; Qian Li; Xiaofeng Yang; Richard B Van Breemen; Judy L Bolton; Gregory R J Thatcher
Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study.
Chemical research in toxicology 2005;18(9):1485-96.
2005: Cassia R Overk; Ping Yao; Lucas R Chadwick; Dejan Nikolic; Yongkai Sun; Muriel Cuendet; Yunfan Deng; Samad Hedayat; Guido F Pauli; Norman R Farnsworth; Richard B Van Breemen; Judy L Bolton
Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).
Journal of agricultural and food chemistry 2005;53(16):6246-53.
2005: Richard B Van Breemen; Yongmei Li
Caco-2 cell permeability assays to measure drug absorption.
Expert opinion on drug metabolism & toxicology 2005;1(2):175-85.
2005: Daniel S Fabricant; Dejan Nikolic; David C Lankin; Shaonong Chen; Birgit U Jaki; Aleksej Krunic; Richard B Van Breemen; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa.
Journal of natural products 2005;68(8):1266-70.
2005: Birgit M Dietz; Young-Hwa Kang; Guowen Liu; Aimee L Eggler; Ping Yao; Lucas R Chadwick; Guido F Pauli; Norman R Farnsworth; Andrew D Mesecar; Richard B Van Breemen; Judy L Bolton
Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.
Chemical research in toxicology 2005;18(8):1296-305.
2005: Richard B Van Breemen
How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia?
The Journal of nutrition 2005;135(8):2062S-4S.
2005: A W Chow; Genoveva Murillo; Chongwoo Yu; Richard B Van Breemen; AW Boddie; John M Pezzuto; Tapas K Das Gupta; Rajendra Mehta
Resveratrol inhibits rhabdomyosarcoma cell proliferation.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2005;14(4):351-6.
2005: Aimee L Eggler; Guowen Liu; John M Pezzuto; Richard B Van Breemen; Andrew D Mesecar
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10070-5.
2005: Yan Li; Xiaofeng Yang; Minsun Chang; James D Yager; Richard B Van Breemen; Judy L Bolton
Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase.
Chemico-biological interactions 2005;152(2-3):151-63.
2005: Andreas I Constantinou; Bethany E P White; Debra A Tonetti; Yanan Yang; Wenzhong Liang; Wenkui Li; Richard B Van Breemen
The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours.
European journal of cancer (Oxford, England : 1990) 2005;41(4):647-54.
2005: Yongkai Sun; Wenkui Li; John F Fitzloff; Richard B Van Breemen
Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba.
Journal of mass spectrometry : JMS 2005;40(3):373-9.
2005: Dejan Nikolic; Yongmei Li; Lucas R Chadwick; Guido F Pauli; Richard B Van Breemen
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes.
Journal of mass spectrometry : JMS 2005;40(3):289-99.
2005: Jianhua Liu; Hong Liu; Richard B Van Breemen; Gregory R J Thatcher; Judy L Bolton
Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
Chemical research in toxicology 2005;18(2):174-82.
2005: Hong Liu; Jianhua Liu; Richard B Van Breemen; Gregory R J Thatcher; Judy L Bolton
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
Chemical research in toxicology 2005;18(2):162-73.
2005: Yongkai Sun; Chungang Gu; Xuemei Liu; Wenzhong Liang; Ping Yao; Judy L Bolton; Richard B Van Breemen
Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors.
Journal of the American Society for Mass Spectrometry 2005;16(2):271-9.
2005: Yaoqiu Zhu; Dejan Nikolic; Richard B Van Breemen; Richard B Silverman
Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.
Journal of the American Chemical Society 2005;127(3):858-68.
2005: Tomoyoshi Kobayashi; Xiaofeng Yang; Lori A Walker; Richard B Van Breemen; R John Solaro
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C.
Journal of molecular and cellular cardiology 2005;38(1):213-8.
2004: Lucas R Chadwick; Dejan Nikolic; Joanna E Burdette; Cassia R Overk; Judy L Bolton; Richard B Van Breemen; Roland Fröhlich; Harry H S Fong; Norman R Farnsworth; Guido F Pauli
Estrogens and congeners from spent hops (Humulus lupulus).
Journal of natural products 2004;67(12):2024-32.
2004: Nancy Booth; Dejan Nikolic; Richard B Van Breemen; Stacie E Geller; Suzanne Banuvar; Lee P Shulman; Norman R Farnsworth
Confusion regarding anticoagulant coumarins in dietary supplements.
Clinical pharmacology and therapeutics 2004;76(6):511-6.
2004: S V Santhana Mariappan; Xun Cheng; Richard B Van Breemen; Louis A Silks; Goutam Gupta
Analysis of GAA/TTC DNA triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry.
Analytical biochemistry 2004;334(2):216-26.
2004: Linning Yu; Hong Liu; Wenkui Li; Fagen Zhang; Connie Luckie; Richard B Van Breemen; Gregory R J Thatcher; Judy L Bolton
Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones.
Chemical research in toxicology 2004;17(7):879-88.
2004: Yongmei Li; Simonida Grubjesic; Dejan Nikolic; D Zhu; Jerome W Kosmeder; Robert M Moriarty; John M Pezzuto; Richard B Van Breemen
In vitro assessment of intestinal permeability and hepatic metabolism of 4'-bromoflavone, a promising cancer chemopreventive agent.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(6):535-47.
2004: Colleen E Piersen; Nancy Booth; Yongkai Sun; W Liang; Joanna E Burdette; Richard B Van Breemen; Stacie E Geller; C Gu; Suzanne Banuvar; Lee P Shulman; Judy L Bolton; Norman R Farnsworth
Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model.
Current medicinal chemistry 2004;11(11):1361-74.
2004: Yan Li; Jiaqin Yao; Minsun Chang; Dejan Nikolic; Linning Yu; James D Yager; Andrew D Mesecar; Richard B Van Breemen; Judy L Bolton
Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase.
Chemical research in toxicology 2004;17(4):512-20.
2004: Dejan Nikolic; Richard B Van Breemen
New metabolic pathways for flavanones catalyzed by rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(4):387-97.
2004: Xiaofeng Yang; Huaping Wu; Tomoyoshi Kobayashi; R John Solaro; Richard B Van Breemen
Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry.
Analytical chemistry 2004;76(5):1532-6.
2004: Dejan Nikolic; Yongmei Li; Lucas R Chadwick; Simonida Grubjesic; Pia Schwab; Peter Metz; Richard B Van Breemen
Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(2):272-9.
2004: Keith W Singletary; Sean L Barnes; Richard B Van Breemen
Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells.
Cancer letters 2004;203(2):139-44.
2004: Jianhua Liu; Joanna E Burdette; Yongkai Sun; S Deng; S M Schlecht; W Zheng; Dejan Nikolic; Gail B Mahady; Richard B Van Breemen; Harry H S Fong; John M Pezzuto; Judy L Bolton; Norman R Farnsworth
Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(1):18-23.
2003: Keith W Singletary; Matthew J Stansbury; Monica Giusti; Richard B Van Breemen; Matthew A Wallig; Agnes Rimando
Inhibition of rat mammary tumorigenesis by concord grape juice constituents.
Journal of agricultural and food chemistry 2003;51(25):7280-6.
2003: Yongmei Li; Young Geun Shin; Chongwoo Yu; Jerome W Kosmeder; Wendy H Hirschelman; John M Pezzuto; Richard B Van Breemen
Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism.
Combinatorial chemistry & high throughput screening 2003;6(8):757-67.
2003: Xingliang Lu; Dejan Nikolic; Deanna J Mitchell; Richard B Van Breemen; John A Mersfelder; Russ Hille; Richard B Silverman
A mechanism for substrate-Induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase.
Bioorganic & medicinal chemistry letters 2003;13(22):4129-32.
2003: Mary M Lyons; Chongwoo Yu; Ramses B Toma; Sool Yeon Cho; Wendy Reiboldt; Jacqueline Lee; Richard B Van Breemen
Resveratrol in raw and baked blueberries and bilberries.
Journal of agricultural and food chemistry 2003;51(20):5867-70.
2003: Joanna E Burdette; Jianhua Liu; Shaonong Chen; Daniel S Fabricant; Colleen E Piersen; Eric L Barker; John M Pezzuto; Andrew D Mesecar; Richard B Van Breemen; Norman R Farnsworth; Judy L Bolton
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.
Journal of agricultural and food chemistry 2003;51(19):5661-70.
2003: Machteld van Lieshout; Clive E West; Peter Van De Bovenkamp; Yan Wang; Yongkai Sun; Richard B Van Breemen; Dewi Permaesih Muhilal; Michiel A Verhoeven; Alain F L Creemers; Johan Lugtenburg
Extraction of carotenoids from feces, enabling the bioavailability of beta-carotene to be studied in Indonesian children.
Journal of agricultural and food chemistry 2003;51(17):5123-30.
2003: Bao-Ning Su; Eun Jung Park; Dejan Nikolic; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Richard B Van Breemen; Harry H S Fong; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora.
Journal of natural products 2003;66(8):1089-93.
2003: Vasilis N Kouloumbos; Despina F Tsipi; Anastasia E Hiskia; Dejan Nikolic; Richard B Van Breemen
Identification of photocatalytic degradation products of diazinon in TiO2 aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry.
Journal of the American Society for Mass Spectrometry 2003;14(8):803-17.
2003: Benjamin M Johnson; Richard B Van Breemen
In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh).
Chemical research in toxicology 2003;16(7):838-46.
2003: Xuemei Liu; Fagen Zhang; Hong Liu; Joanna E Burdette; Yan Li; Cassia R Overk; Emily Pisha; Jiaqin Yao; Richard B Van Breemen; Steven M Swanson; Judy L Bolton
Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin.
Chemical research in toxicology 2003;16(6):741-9.
2003: Benjamin M Johnson; Samuel X Qiu; Shide Zhang; Fagen Zhang; Joanna E Burdette; Linning Yu; Judy L Bolton; Richard B Van Breemen
Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).
Chemical research in toxicology 2003;16(6):733-40.
2003: Jiaqin Yao; Yan Li; Minsun Chang; Huaping Wu; Xiaofeng Yang; Julie E Goodman; Xuemei Liu; Hong Liu; Andrew D Mesecar; Richard B Van Breemen; James D Yager; Judy L Bolton
Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase.
Chemical research in toxicology 2003;16(5):668-75.
2003: Jian-Qiao Gu; Wenkui Li; Young-Hwa Kang; Bao-Ning Su; Harry H S Fong; Richard B Van Breemen; John M Pezzuto; A Douglas Kinghorn
Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts.
Chemical & pharmaceutical bulletin 2003;51(5):530-9.
2003: Bao-Ning Su; Eun Jung Park; Dejan Nikolic; Bernard D Santarsiero; Andrew D Mesecar; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Richard B Van Breemen; Harry H S Fong; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity.
The Journal of organic chemistry 2003;68(6):2350-61.
2003: Liqiong Fang; Natasa Pajkovic; Yan Wang; Chungang Gu; Richard B Van Breemen
Quantitative analysis of lycopene isomers in human plasma using high-performance liquid chromatography-tandem mass spectrometry.
Analytical chemistry 2003;75(4):812-7.
2003: Wenkui Li; Yongkai Sun; Joy Joseph; John F Fitzloff; Harry H S Fong; Richard B Van Breemen
p-Hydroxybenzoic acid alkyl esters in Andrographis paniculata herbs, commercial extracts, and formulated products.
Journal of agricultural and food chemistry 2003;51(2):524-9.
2003: Xun Cheng; Young Geun Shin; Barry S Levine; Adaline C Smith; Joseph E Tomaszewski; Richard B Van Breemen
Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray liquid chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM 2003;17(18):2089-92.
2003: Wenkui Li; Yongkai Sun; Wenzhong Liang; John F Fitzloff; Richard B Van Breemen
Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2003;17(9):978-82.
2003: Chongwoo Yu; Young Geun Shin; Jerome W Kosmeder; John M Pezzuto; Richard B Van Breemen
Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.
Rapid communications in mass spectrometry : RCM 2003;17(4):307-13.
2003: Machteld van Lieshout; Clive E West; Richard B Van Breemen
Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly beta-carotene, in humans: a review.
The American journal of clinical nutrition 2003;77(1):12-28.
2002: Chongwoo Yu; Young Geun Shin; Anita Chow; Yongmei Li; Jerome W Kosmeder; Yong Sup Lee; Wendy H Hirschelman; John M Pezzuto; Rajendra Mehta; Richard B Van Breemen
Human, rat, and mouse metabolism of resveratrol.
Pharmaceutical research 2002;19(12):1907-14.
2002: Joanna E Burdette; Shaonong Chen; Zhi-Zhen Lu; Haiyan Xu; Bethany E P White; Daniel S Fabricant; Jianhua Liu; Harry H S Fong; Norman R Farnsworth; Andreas I Constantinou; Richard B Van Breemen; John M Pezzuto; Judy L Bolton
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.
Journal of agricultural and food chemistry 2002;50(24):7022-8.
2002: Phyllis E Bowen; Longwen Chen; Maria Stacewicz-Sapuntzakis; Claudine Duncan; Roohollah Sharifi; Luna Ghosh; Hyung-Sook Kim; Konstantin Christov-Tzelkov; Richard B Van Breemen
Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis.
Experimental biology and medicine (Maywood, N.J.) 2002;227(10):886-93.
2002: Yanan Yang; Dejan Nikolic; Steven M Swanson; Richard B Van Breemen
Quantitative determination of N7-methyldeoxyguanosine and O6-methyldeoxyguanosine in DNA by LC-UV-MS-MS.
Analytical chemistry 2002;74(20):5376-82.
2002: Wenkui Li; Yongkai Sun; John F Fitzloff; Richard B Van Breemen
Evaluation of commercial ginkgo and echinacea dietary supplements for colchicine using liquid chromatography-tandem mass spectrometry.
Chemical research in toxicology 2002;15(9):1174-8.
2002: Gail S Prins; William Y Chang; Yan Wang; Richard B Van Breemen
Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure.
Endocrinology 2002;143(9):3628-40.
2002: Richard B Van Breemen; Xiaoying Xu; Marlos Viana; Longwen Chen; Maria Stacewicz-Sapuntzakis; Claudine Duncan; Phyllis E Bowen; Roohollah Sharifi
Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce.
Journal of agricultural and food chemistry 2002;50(8):2214-9.
2002: Xuemei Liu; Jiaqin Yao; Emily Pisha; Yanan Yang; Yousheng Hua; Richard B Van Breemen; Judy L Bolton
Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha.
Chemical research in toxicology 2002;15(4):512-9.
2002: Benjamin M Johnson; Dejan Nikolic; Richard B Van Breemen
Applications of pulsed ultrafiltration-mass spectrometry.
Mass spectrometry reviews 2002;21(2):76-86.
2002: Young Geun Shin; Judy L Bolton; Richard B Van Breemen
Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry.
Combinatorial chemistry & high throughput screening 2002;5(1):59-64.
2002: Yan Wang; Florentina Catana; Yanan Yang; Robin Roderick; Richard B Van Breemen
An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine.
Journal of agricultural and food chemistry 2002;50(3):431-5.
2002: Joanna E Burdette; Jianhua Liu; Daniel D Lantvit; Eula Lim; Nancy Booth; Krishna P L Bhat; Samad Hedayat; Richard B Van Breemen; Andreas I Constantinou; John M Pezzuto; Norman R Farnsworth; Judy L Bolton
Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.
The Journal of nutrition 2002;132(1):27-30.
2001: Longwen Chen; Maria Stacewicz-Sapuntzakis; Claudine Duncan; Roohollah Sharifi; Luna Ghosh; Richard B Van Breemen; D Ashton; Phyllis E Bowen
Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.
Journal of the National Cancer Institute 2001;93(24):1872-9.
2001: Fagen Zhang; Steven M Swanson; Richard B Van Breemen; Xuemei Liu; Yanan Yang; C Gu; Judy L Bolton
Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases.
Chemical research in toxicology 2001;14(12):1654-9.
2001: Dan Yao; Fagen Zhang; Linning Yu; Yanan Yang; Richard B Van Breemen; Judy L Bolton
Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.
Chemical research in toxicology 2001;14(12):1643-53.
2001: Spiros D Garbis; Alida Melse-Boonstra; Clive E West; Richard B Van Breemen
Determination of folates in human plasma using hydrophilic interaction chromatography-tandem mass spectrometry.
Analytical chemistry 2001;73(22):5358-64.
2001: Benjamin M Johnson; Judy L Bolton; Richard B Van Breemen
Screening botanical extracts for quinoid metabolites.
Chemical research in toxicology 2001;14(11):1546-51.
2001: Young Geun Shin; Richard B Van Breemen
Analysis and screening of combinatorial libraries using mass spectrometry.
Biopharmaceutics & drug disposition 2001;22(7-8):353-72.
2001: Yihan Wang; W Y Chang; Gail S Prins; Richard B Van Breemen
Simultaneous determination of all-trans, 9-cis, 13-cis retinoic acid and retinol in rat prostate using liquid chromatography-mass spectrometry.
Journal of mass spectrometry : JMS 2001;36(8):882-8.
2001: Deanna J Mitchell; Dejan Nikolic; M H Jang; Richard B Van Breemen; R Hille; Richard B Silverman
Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine.
Biochemistry 2001;40(29):8523-30.
2001: Deanna J Mitchell; Dejan Nikolic; Richard B Van Breemen; Richard B Silverman
Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct.
Bioorganic & medicinal chemistry letters 2001;11(13):1757-60.
2001: Fagen Zhang; Dan Yao; Yousheng Hua; Richard B Van Breemen; Judy L Bolton
Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone.
Chemical research in toxicology 2001;14(6):754-63.
2001: Deanna J Mitchell; Dejan Nikolic; E Rivera; SO Sablin; S Choi; Richard B Van Breemen; TP Singer; Richard B Silverman
Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N.
Biochemistry 2001;40(18):5447-56.
2001: Jianhua Liu; Joanna E Burdette; Haiyan Xu; C Gu; Richard B Van Breemen; Krishna P L Bhat; Nancy Booth; Andreas I Constantinou; John M Pezzuto; Harry H S Fong; Norman R Farnsworth; Judy L Bolton
Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.
Journal of agricultural and food chemistry 2001;49(5):2472-9.
2001: Machteld van Lieshout; Clive E West; D Permaesih; Yan Wang; Lucy Xu; Richard B Van Breemen; Alain F L Creemers; Michiel A Verhoeven; Johan Lugtenburg
Bioefficacy of beta-carotene dissolved in oil studied in children in Indonesia.
The American journal of clinical nutrition 2001;73(5):949-58.
2001: E J Park; D Lee; Young Geun Shin; Daniel D Lantvit; Richard B Van Breemen; A Douglas Kinghorn; John M Pezzuto
Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2001;754(2):327-32.
2001: Minsun Chang; Young Geun Shin; Richard B Van Breemen; Sylvie Blond; Judy L Bolton
Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin.
Biochemistry 2001;40(15):4811-20.
2001: Dejan Nikolic; Richard B Van Breemen
DNA oxidation induced by cyclooxygenase-2.
Chemical research in toxicology 2001;14(4):351-4.
2001: Andreas I Constantinou; Daniel D Lantvit; Michael E Hawthorne; Xiping Xu; Richard B Van Breemen; John M Pezzuto
Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats.
Nutrition and cancer 2001;41(1-2):75-81.
2001: Y Hua; S B Wainhaus; Y Yang; L Shen; Y Xiong; X Xu; F Zhang; Judy L Bolton; Richard B Van Breemen
Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides.
Journal of the American Society for Mass Spectrometry 2001;12(1):80-7.
2000: HE Westenburg; K J Lee; Sang Kook Lee; Harry H S Fong; Richard B Van Breemen; John M Pezzuto; A Douglas Kinghorn
Activity-guided isolation of antioxidative constituents of Cotinus coggygria.
Journal of natural products 2000;63(12):1696-8.
2000: Wenkui Li; C Gu; Hong-Jie Zhang; D V Awang; John F Fitzloff; Harry H S Fong; Richard B Van Breemen
Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng).
Analytical chemistry 2000;72(21):5417-22.
2000: Yan Wang; Lucy Xu; Machteld van Lieshout; Clive E West; Johan Lugtenburg; Michiel A Verhoeven; Alain F L Creemers; Richard B Van Breemen
A liquid chromatography-mass spectrometry method for the quantification of bioavailability and bioconversion of beta-carotene to retinol in humans.
Analytical chemistry 2000;72(20):4999-5003.
2000: L K Henry; N L Puspitasari-Nienaber; M Jarén-Galán; Richard B Van Breemen; George L Catignani; S J Schwartz
Effects of ozone and oxygen on the degradation of carotenoids in an aqueous model system.
Journal of agricultural and food chemistry 2000;48(10):5008-13.
2000: Dejan Nikolic; S Habibi-Goudarzi; D G Corley; S Gafner; John M Pezzuto; Richard B Van Breemen
Evaluation of cyclooxygenase-2 inhibitors using pulsed ultrafiltration mass spectrometry.
Analytical chemistry 2000;72(16):3853-9.
2000: Ying Chen; Xuemei Liu; Emily Pisha; Andreas I Constantinou; Yousheng Hua; L Shen; Richard B Van Breemen; Ebrahim Elguindi; Sylvie Blond; Fagen Zhang; Judy L Bolton
A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines.
Chemical research in toxicology 2000;13(5):342-50.
1999: C Gu; Dejan Nikolic; J Lai; X Xu; Richard B Van Breemen
Assays of ligand-human serum albumin binding using pulsed ultrafiltration and liquid chromatography-mass spectrometry.
Combinatorial chemistry & high throughput screening 1999;2(6):353-9.
1999: Xiping Xu; Yihan Wang; Andreas I Constantinou; Maria Stacewicz-Sapuntzakis; Phyllis E Bowen; Richard B Van Breemen
Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture.
Lipids 1999;34(10):1031-6.
1999: W L Hadden; R H Watkins; L W Levy; E Regalado; D M Rivadeneira; Richard B Van Breemen; Steven J Schwartz
Carotenoid composition of marigold (Tagetes erecta) flower extract used as nutritional supplement.
Journal of agricultural and food chemistry 1999;47(10):4189-94.
1999: Magdalena Korecka; Dejan Nikolic; Richard B Van Breemen; Leslie M Shaw
The apparent inhibition of inosine monophosphate dehydrogenase by mycophenolic acid glucuronide is attributable to the presence of trace quantities of mycophenolic acid.
Clinical chemistry 1999;45(7):1047-50.
1999: Dejan Nikolic; Peter Fan; Judy L Bolton; Richard B Van Breemen
Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry.
Combinatorial chemistry & high throughput screening 1999;2(3):165-75.
1999: Fagen Zhang; Ying Chen; Emily Pisha; L Shen; Y Xiong; Richard B Van Breemen; Judy L Bolton
The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.
Chemical research in toxicology 1999;12(2):204-13.
1999: H S Chung; L C Chang; S K Lee; L A Shamon; Richard B Van Breemen; Rajendra Mehta; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity.
Journal of agricultural and food chemistry 1999;47(1):36-41.
1998: Ying Chen; L Shen; Fagen Zhang; S S Lau; Richard B Van Breemen; Dejan Nikolic; Judy L Bolton
The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.
Chemical research in toxicology 1998;11(9):1105-11.
1998: Minsun Chang; Fagen Zhang; L Shen; N Pauss; I Alam; Richard B Van Breemen; Sylvie Blond; Judy L Bolton
Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens.
Chemical research in toxicology 1998;11(7):758-65.
1998: Dejan Nikolic; Richard B Van Breemen
Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry.
Combinatorial chemistry & high throughput screening 1998;1(1):47-55.
1998: L Shen; S Qiu; Ying Chen; Fagen Zhang; Richard B Van Breemen; Dejan Nikolic; Judy L Bolton
Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.
Chemical research in toxicology 1998;11(2):94-101.
1998: Richard B Van Breemen; Dejan Nikolic; Judy L Bolton
Metabolic screening using on-line ultrafiltration mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(2):85-90.
1998: Richard B Van Breemen; Dejan Nikolic; Lucy Xu; Y Xiong; Machteld van Lieshout; Clive E West; A B Schilling
Development of a method for quantitation of retinol and retinyl palmitate in human serum using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
Journal of chromatography. A 1998;794(1-2):245-51.
1997: Y Z Zhao; Richard B Van Breemen; Dejan Nikolic; C R Huang; CP Woodbury; A Schilling; Duane L Venton
Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry.
Journal of medicinal chemistry 1997;40(25):4006-12.
1997: Judy L Bolton; Emily Pisha; L Shen; ES Krol; S L Iverson; Z Huang; Richard B Van Breemen; John M Pezzuto
The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells.
Chemico-biological interactions 1997;106(2):133-48.
1997: Richard B Van Breemen; C R Huang; Dejan Nikolic; CP Woodbury; Y Z Zhao; Duane L Venton
Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries.
Analytical chemistry 1997;69(11):2159-64.
1997: L Shen; Emily Pisha; Z Huang; John M Pezzuto; ES Krol; Z Alam; Richard B Van Breemen; Judy L Bolton
Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.
Carcinogenesis 1997;18(5):1093-101.
1996: Richard B Van Breemen; C R Huang
High-performance liquid chromatography-electrospray mass spectrometry of retinoids.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(9):1098-101.
1995: G A Spanos; Steven J Schwartz; Richard B Van Breemen; C H Huang
High-performance liquid chromatography with light-scattering detection and desorption chemical-ionization tandem mass spectrometry of milk fat triacylglycerols.
Lipids 1995;30(1):85-90.
1993: R K Blackburn; Richard B Van Breemen
Application of an immobilized digestive enzyme assay to measure chemical and enzymatic hydrolysis of the cyclic peptide antibiotic lysobactin.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(4):573-9.
1992: Richard B Van Breemen; R G Davis
Rates of peptide proteolysis measured using liquid chromatography and continuous-flow fast atom bombardment mass spectrometry.
Analytical chemistry 1992;64(19):2233-7.
1991: Richard B Van Breemen; M G Bartlett; Y H Tsou; C Culver; Harold E Swaisgood; S E Unger
Degradation of peptide drugs by immobilized digestive proteases.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(3):683-90.
1991: L B Martin; A F Schreiner; Richard B Van Breemen
Characterization of cisplatin adducts of oligonucleotides by fast atom bombardment mass spectrometry.
Analytical biochemistry 1991;193(1):6-15.
1990: D R Goodlett; F B Armstrong; R J Creech; Richard B Van Breemen
Formylated peptides from cyanogen bromide digests identified by fast atom bombardment mass spectrometry.
Analytical biochemistry 1990;186(1):116-20.
1989: Richard B Van Breemen; J C Le
Enhanced sensitivity of peptide analysis by fast-atom bombardment mass spectrometry using nitrocellulose as a substrate.
Rapid communications in mass spectrometry : RCM 1989;3(2):20-4.
1988: Richard B Van Breemen; M Stogniew; Catherine Fenselau
Characterization of acyl-linked glucuronides by electron impact and fast atom bombardment mass spectrometry.
Biomedical & environmental mass spectrometry 1988;17(2):97-103.
1987: Richard B Van Breemen; Catherine Fenselau; Robert J Cotter; A J Curtis; G Connolly
Derivatives of dicyclopentadiene in ground water.
Biomedical & environmental mass spectrometry 1987;14(3):97-102.
1986: Richard B Van Breemen; Catherine Fenselau; W Mogilevsky; G B Odell
Reaction of bilirubin glucuronides with serum albumin.
Journal of chromatography 1986;383(2):387-92.
1986: Richard B Van Breemen; Catherine Fenselau
Reaction of 1-O-acyl glucuronides with 4-(p-nitrobenzyl)pyridine.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(2):197-201.
1986: Richard B Van Breemen; Catherine Fenselau; D M Dulik
Activated phase II metabolites: comparison of alkylation by 1-O-acyl glucuronides and acyl sulfates.
Advances in experimental medicine and biology 1986;197():423-9.
1985: Richard B Van Breemen; Catherine Fenselau
Acylation of albumin by 1-O-acyl glucuronides.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(3):318-20.
1984: Richard B Van Breemen; J C Tabet; Robert J Cotter
Characterization of oxygen-linked glucuronides by laser desorption mass spectrometry.
Biomedical mass spectrometry 1984;11(6):278-83.