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Wim Van De Ven

Research Profile

Chemicals & Drugs

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Mouse

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Salivary Gland Neoplasms

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Jingjing Zhu; Guido David; Jeroen Declercq; Gholamreza H Ghassabeh; Jörg Kinne; Iris Lindberg; Sandra M P Meulemans; Serge Muyldermans; Bart Roucourt; Wim J M Van De Ven; Alphons J M Vermorken; John W M Creemers
Generation and characterization of non-competitive furin-inhibiting nanobodies.
Xu Chao; Chao Chen; Lili Guo; Mingli Peng; Wim J M Van De Ven; Alphonsus J M Vermorken; Zhuoli Zhang; Jingjing Zhu; Yali Cui
A novel magnetic nanoparticle drug carrier for enhanced cancer chemotherapy.
Jeroen Declercq; Caterina Di Pietro; Nadine Ectors; Conny Gysemans; Harry Heimberg; Anujith Kumar; Katleen Lemaire; Chantal Mathieu; Daniel Pipeleers; Anica Schraenen; Frans C Schuit; Marc Van de Casteele; Wim J M Van De Ven; Leentje Van Lommel; Marie Chintinne; Catherine M Verfaillie
Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.

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All Publications

2012: Jingjing Zhu; Guido David; Jeroen Declercq; Gholamreza H Ghassabeh; Jörg Kinne; Iris Lindberg; Sandra M P Meulemans; Serge Muyldermans; Bart Roucourt; Wim J M Van De Ven; Alphons J M Vermorken; John W M Creemers
Generation and characterization of non-competitive furin-inhibiting nanobodies.
The Biochemical journal 2012;448(1):73-82.
2012: Xu Chao; Chao Chen; Lili Guo; Mingli Peng; Wim J M Van De Ven; Alphonsus J M Vermorken; Zhuoli Zhang; Jingjing Zhu; Yali Cui
A novel magnetic nanoparticle drug carrier for enhanced cancer chemotherapy.
PloS one 2012;7(10):e40388.
2011: Jeroen Declercq; Caterina Di Pietro; Nadine Ectors; Conny Gysemans; Harry Heimberg; Anujith Kumar; Katleen Lemaire; Chantal Mathieu; Daniel Pipeleers; Anica Schraenen; Frans C Schuit; Marc Van de Casteele; Wim J M Van De Ven; Leentje Van Lommel; Marie Chintinne; Catherine M Verfaillie
Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.
Cell transplantation 2011;20(8):1285-97.
2010: Jeroen Declercq; Anujith Kumar; Janna A Van Diepen; Irene O C M Vroegrijk; Conny Gysemans; Caterina Di Pietro; Peter J Voshol; Chantal Mathieu; Nadine Ectors; Wim J M Van De Ven; Catherine M Verfaillie
Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice.
Diabetes 2010;59(8):1957-65.
2010: Dries Castermans; Karolien Volders; An Crepel; Liesbeth Backx; Rita De Vos; Kathleen Freson; Sandra Meulemans; Joris R Vermeesch; Connie T R M Schrander-Stumpel; Peter De Rijk; Jurgen Del-Favero; Chris Van Geet; Wim J M Van De Ven; Jean G Steyaert; Koen Devriendt; John W M Creemers
SCAMP5, NBEA and AMISYN: three candidate genes for autism involved in secretion of large dense-core vesicles.
Human molecular genetics 2010;19(7):1368-78.
2009: Hilke B V K Vervenne; Koen R M O Crombez; Els L Delvaux; Veerle Janssens; Wim J M Van De Ven; Marleen MR Petit
Targeted disruption of the mouse Lipoma Preferred Partner gene.
Biochemical and biophysical research communications 2009;379(2):368-73.
2008: Marcin Ratajewski; Wim J M Van De Ven; Grzegorz Bartosz; Lukasz Pulaski
The human pseudoxanthoma elasticum gene ABCC6 is transcriptionally regulated by PLAG family transcription factors.
Human genetics 2008;124(5):451-63.
2008: Jeroen Declercq; Ivar Skaland; Frederik Van Dyck; Emiel A M Janssen; Jan P Baak; Maria Drijkoningen; Wim J M Van De Ven
Adenomyoepitheliomatous lesions of the mammary glands in transgenic mice with targeted PLAG1 overexpression.
International journal of cancer. Journal international du cancer 2008;123(7):1593-600.
2008: Dries Castermans; Bernard Thienpont; Karolien Volders; An Crepel; Joris R Vermeesch; Connie T Schrander-Stumpel; Wim J M Van De Ven; Jean Steyaert; John W M Creemers; koenraad devriendt
Position effect leading to haploinsufficiency in a mosaic ring chromosome 14 in a boy with autism.
European journal of human genetics : EJHG 2008;16(10):1187-92.
2008: Els Louagie; Neil A Taylor; Daisy Flamez; Anton J M Roebroek; Nicholas A Bright; Sandra M P Meulemans; Roel Quintens; Pedro L Herrera; Frans Schuit; Wim J M Van De Ven; John W M Creemers
Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12319-24.
2008: Hilke B V K Vervenne; Koen R M O Crombez; Kathleen Lambaerts; Lara Carvalho; Mathias Köppen; Carl-Philipp Heisenberg; Wim J M Van De Ven; Marleen MR Petit
Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation.
Developmental biology 2008;320(1):267-77.
2008: Jeroen Declercq; Frederik Van Dyck; Boudewijn Van Damme; Wim J M Van De Ven
Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice.
International journal of oncology 2008;32(5):1041-7.
2008: Isabelle Cleynen; Wim J M Van De Ven
The HMGA proteins: a myriad of functions (Review).
International journal of oncology 2008;32(2):289-305.
2008: Frederik Van Dyck; Ilse Scroyen; Jeroen Declercq; Raf Sciot; Barbara Kahn; Roger Lijnen; Wim J M Van De Ven
aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.
International journal of oncology 2008;32(1):33-40.
2007: Frederik Van Dyck; Caroline V Braem; Zhao Chen; Jeroen Declercq; Rob Deckers; Byeong-Moo Kim; Susumu Ito; Michele K Wu; David E Cohen; Mieke Dewerchin; Rita Derua; Etienne Waelkens; Laurence Fiette; Anton J M Roebroek; Frans Schuit; Wim J M Van De Ven; Ramesh A Shivdasani
Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
Cell metabolism 2007;6(5):406-13.
2007: Isabelle Cleynen; Jan R Brants; Kristel Peeters; Rob Deckers; Maria Debiec-Rychter; Raf Sciot; Wim J M Van De Ven; Marleen MR Petit
HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB.
Molecular cancer research : MCR 2007;5(4):363-72.
2007: Frederik Van Dyck; Jeroen Declercq; Caroline V Braem; Wim J M Van De Ven
PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review).
International journal of oncology 2007;30(4):765-74.
2007: Dries Castermans; Joris R Vermeesch; Jean-Pierre Fryns; Jean Steyaert; Wim J M Van De Ven; John W M Creemers; koenraad devriendt
Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism.
European journal of human genetics : EJHG 2007;15(4):422-31.
2006: Hilde Peeters; Marianne L Voz; Kristin Verschueren; Bart De Cat; Hélène Pendeville; Bernard Thienpont; Ann Schellens; John W Belmont; Guido David; Wim J M Van De Ven; Jean-Pierre Fryns; Marc Gewillig; Danny Huylebroeck; Bernard Peers; koenraad devriendt
Sesn1 is a novel gene for left-right asymmetry and mediating nodal signaling.
Human molecular genetics 2006;15(22):3369-77.
2006: Baoqiang Guo; Rosemary E Sallis; Amanda Greenall; Marleen MR Petit; Erik Jansen; Leonie Young; Wim J M Van De Ven; Andrew D Sharrocks
The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3.
Molecular and cellular biology 2006;26(12):4529-38.
2005: Marleen MR Petit; Koen R M O Crombez; Hilke B V K Vervenne; Nancy Weyns; Wim J M Van De Ven
The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins.
FEBS letters 2005;579(22):5061-8.
2005: Jeroen Declercq; Frederik Van Dyck; Caroline V Braem; Isabelle C C Van Valckenborgh; Marianne L Voz; Michel Wassef; Luc Schoonjans; Boudewijn Van Damme; Laurence Fiette; Wim J M Van De Ven
Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression.
Cancer research 2005;65(11):4544-53.
2005: Philippe Debeer; Christel Huysmans; Wim J M Van De Ven; Jean-Pierre Fryns; koenraad devriendt
Carpal and tarsal synostoses and transverse reduction defects of the toes in two brothers heterozygous for a double de novo NOGGIN mutation.
American journal of medical genetics. Part A 2005;134(3):318-20.
2005: Sean F. Landrette; Ya-Huei Kuo; Karen Hensen; Sahar Barjesteh van Waalwijk van Doorn-Khosrovani; Paola N Perrat; Wim J M Van De Ven; Ruud Delwel; Lucio H Castilla
Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11.
Blood 2005;105(7):2900-7.
2005: Koen R M O Crombez; Els M R Vanoirbeek; Wim J M Van De Ven; Marleen MR Petit
Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2.
Molecular cancer research : MCR 2005;3(2):63-70.
2005: Marleen MR Petit; Sandra M P Meulemans; Philippe Alen; Torik A Y Ayoubi; Erik Jansen; Wim J M Van De Ven
The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.
BMC cell biology 2005;6(1):1.
2004: Anton J M Roebroek; Neil A Taylor; Els Louagie; Ilse Pauli; Liesbet Smeijers; An Snellinx; Annick Lauwers; Wim J M Van De Ven; Dieter Hartmann; John W M Creemers
Limited redundancy of the proprotein convertase furin in mouse liver.
The Journal of biological chemistry 2004;279(51):53442-50.
2004: Karen Hensen; Caroline V Braem; Jeroen Declercq; Frederik Van Dyck; Mieke Dewerchin; Laurence Fiette; Carl Denef; Wim J M Van De Ven
Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility.
Development, growth & differentiation 2004;46(5):459-70.
2004: Frederik Van Dyck; Els L D Delvaux; Wim J M Van De Ven; Marcela V Chavez
Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation.
The Journal of biological chemistry 2004;279(34):36121-31.
2004: Philippe Debeer; Jean-Pierre Fryns; koenraad devriendt; E Baten; Christel Huysmans; Wim J M Van De Ven
A novel NOG mutation Pro37Arg in a family with tarsal and carpal synostoses.
American journal of medical genetics. Part A 2004;128A(4):439-40.
2004: Jan R Brants; Torik A Y Ayoubi; Kiran Chada; Kathleen Marchal; Wim J M Van De Ven; Marleen MR Petit
Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2.
FEBS letters 2004;569(1-3):277-83.
2004: Philippe Debeer; L Vandenbossche; T J L de Ravel; C Desloovere; Luc De Smet; Christel Huysmans; Reinhilde Thoelen; Joris R Vermeesch; Wim J M Van De Ven; Jean-Pierre Fryns
Bilateral complete radioulnar synostosis associated with ectrodactyly and sensorineural hearing loss: a variant of SHFM1.
Clinical genetics 2004;65(2):153-5.
2004: Marianne L Voz; Janick Mathys; Karen Hensen; Hélène Pendeville; Isabelle C C Van Valckenborgh; Christophe Henri Van Huffel; Marcela Chavez; Boudewijn Van Damme; Bart De Moor; Yves Moreau; Wim J M Van De Ven
Microarray screening for target genes of the proto-oncogene PLAG1.
Oncogene 2004;23(1):179-91.
2003: Jeroen Declercq; Karen Hensen; Wim J M Van De Ven; Marcela Chavez
PLAG proteins: how they influence apoptosis and cell proliferation.
Annals of the New York Academy of Sciences 2003;1010():264-5.
2003: Neil A Taylor; Wim J M Van De Ven; John W M Creemers
Curbing activation: proprotein convertases in homeostasis and pathology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1215-27.
2003: Marleen MR Petit; Sandra M P Meulemans; Wim J M Van De Ven
The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein.
The Journal of biological chemistry 2003;278(4):2157-68.
2002: Philippe Debeer; R Mols; Christel Huysmans; koenraad devriendt; Wim J M Van De Ven; Jean-Pierre Fryns
Involvement of a palindromic chromosome 22-specific low-copy repeat in a constitutional t(X; 22)(q27;q11).
Clinical genetics 2002;62(5):410-4.
2002: Philippe Debeer; T J L de Ravel; koenraad devriendt; Jean-Pierre Fryns; Christel Huysmans; Wim J M Van De Ven
Human homologues of Osr1 and Osr2 are not involved in a syndrome with distal limb deficiencies, oral abnormalities, and renal defects.
American journal of medical genetics 2002;111(4):455-6.
2002: Philippe Debeer; Luc De Smet; Wim J M Van De Ven; G Fabry; J P Fryns
Genes and orthopedics: from gene to clinic and vice versa.
Acta orthopaedica Belgica 2002;68(3):203-14.
2002: Caroline V Braem; Koen Kas; Eef Meyen; Maria Debiec-Rychter; Wim J M Van De Ven; Marianne L Voz
Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal.
The Journal of biological chemistry 2002;277(22):19673-8.
2002: Karen Hensen; Isabelle C C Van Valckenborgh; Koen Kas; Wim J M Van De Ven; Marianne L Voz
The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities.
Cancer research 2002;62(5):1510-7.
2002: Philippe Debeer; Eric F P M Schoenmakers; Waleed O Twal; Scott Argraves; L De Smet; Jean-Pierre Fryns; Wim J M Van De Ven
The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly.
Journal of medical genetics 2002;39(2):98-104.
2001: Maria Debiec-Rychter; Isabelle C C Van Valckenborgh; C Van den Broeck; Anne Hagemeijer; Wim J M Van De Ven; Koen Kas; Boudewijn Van Damme; Marianne L Voz
Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells.
Laboratory investigation; a journal of technical methods and pathology 2001;81(9):1289-97.
2001: IH Lemmens; L Forsberg; Anna A J Pannett; Eef Meyen; Fredrik Piehl; J J Turner; Wim J M Van De Ven; Rajesh V Thakker; Catharina Larsson; Koen Kas
Menin interacts directly with the homeobox-containing protein Pem.
Biochemical and biophysical research communications 2001;286(2):426-31.
2000: JW van de Loo; M Teuchert; Ilse Pauli; E Plets; Wim J M Van De Ven; John W M Creemers
Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.
The Biochemical journal 2000;352 Pt 3():827-33.
2000: John W M Creemers; JW van de Loo; E Plets; L M Hendershot; Wim J M Van De Ven
Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation.
The Journal of biological chemistry 2000;275(49):38842-7.
2000: Marianne L Voz; Wim J M Van De Ven; Koen Kas
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Advances in dental research 2000;14():81-3.
2000: Philippe Debeer; Eric F P M Schoenmakers; Reinhilde Thoelen; Maureen Holvoet; T Kuittinen; Guy Fabry; Jean-Pierre Fryns; Frances R Goodman; Wim J M Van De Ven
Physical map of a 1.5 mb region on 12p11.2 harbouring a synpolydactyly associated chromosomal breakpoint.
European journal of human genetics : EJHG 2000;8(8):561-70.
2000: Marianne L Voz; N S Agten; Wim J M Van De Ven; Koen Kas
PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II.
Cancer research 2000;60(1):106-13.
2000: Marleen MR Petit; J Fradelizi; Roy M Golsteyn; Torik A Y Ayoubi; B Menichi; Daniel Louvard; Wim J M Van De Ven; Evelyne Friederich
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.
Molecular biology of the cell 2000;11(1):117-29.
2000: IH Lemmens; Filip Farnebo; Fredrik Piehl; J Merregaert; Wim J M Van De Ven; Catharina Larsson; Koen Kas
Molecular characterization of human and murine C11orf5, a new member of the FAUNA gene cluster.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(1):78-80.
1999: Torik A Y Ayoubi; Erik Jansen; Sandra M P Meulemans; Wim J M Van De Ven
Regulation of HMGIC expression: an architectural transcription factor involved in growth control and development.
Oncogene 1999;18(36):5076-87.
1999: Marleen MR Petit; Eric F P M Schoenmakers; Christel Huysmans; Jan Geurts; Nils Mandahl; Wim J M Van De Ven
LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes.
Genomics 1999;57(3):438-41.
1999: Eric F P M Schoenmakers; Christel Huysmans; Wim J M Van De Ven
Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas.
Cancer research 1999;59(1):19-23.
1998: Wim J M Van De Ven
Genetic basis of uterine leiomyoma: involvement of high mobility group protein genes.
European journal of obstetrics, gynecology, and reproductive biology 1998;81(2):289-93.
1998: Anton J M Roebroek; Lieve Umans; Ilse Pauli; Elizabeth J Robertson; Fred Van Leuven; Wim J M Van De Ven; Daniel B Constam
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.
Development (Cambridge, England) 1998;125(24):4863-76.
1998: B A Th F Gabreëls; Dick F Swaab; D P de Kleijn; A Dean; N G Seidah; JW van de Loo; Wim J M Van De Ven; G J Martens; Fijs W B van Leeuwen
The vasopressin precursor is not processed in the hypothalamus of Wolfram syndrome patients with diabetes insipidus: evidence for the involvement of PC2 and 7B2.
The Journal of clinical endocrinology and metabolism 1998;83(11):4026-33.
1998: Marleen MR Petit; S Swarts; J A Bridge; Wim J M Van De Ven
Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma.
Cancer genetics and cytogenetics 1998;106(1):18-23.
1998: Koen Kas; Marianne L Voz; Karen Hensen; Eef Meyen; Wim J M Van De Ven
Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.
The Journal of biological chemistry 1998;273(36):23026-32.
1998: Anton J M Roebroek; B Contreras; Ilse Pauli; Wim J M Van De Ven
cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons.
Genomics 1998;51(1):98-106.
1998: Philippe Debeer; Eric F P M Schoenmakers; L De Smet; Wim J M Van De Ven; J P Fryns
Co-segregation of an apparently balanced reciprocal t(12;22)(p11.2;q13.3) with a complex type of 3/3'/4 synpolydactyly associated with metacarpal, metatarsal and tarsal synostoses in three family members.
Clinical dysmorphology 1998;7(3):225-8.
1998: Jo W M Höppener; MJ de Wit; A Y Simarro-Doorten; Janine F M Roijers; H M van Herrewaarden; Cornelis J M Lips; F Parente; Danielle Quincey; Patrick Gaudray; S Khodaei; Günther Weber; Bin Tean Teh; Filip Farnebo; Catharina Larsson; Chang X Zhang; Alain Calender; Anna A J Pannett; Simon A Forbes; J H Bassett; Rajesh V Thakker; IH Lemmens; Wim J M Van De Ven; Koen Kas
A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1.
Genomics 1998;50(2):251-9.
1998: IH Lemmens; Koen Kas; J Merregaert; Wim J M Van De Ven
Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.
Genomics 1998;49(3):437-42.
1998: Peter Groenen; G Vanderlinden; koenraad devriendt; Jean-Pierre Fryns; Wim J M Van De Ven
Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia.
Genomics 1998;49(2):218-29.
1998: Marianne L Voz; AK Aström; Koen Kas; Joachim Mark; Göran Stenman; Wim J M Van De Ven
The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter.
Oncogene 1998;16(11):1409-16.
1998: Jan Geurts; Eric F P M Schoenmakers; Eva Röijer; AK Aström; Göran Stenman; Wim J M Van De Ven
Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas.
Oncogene 1998;16(7):865-72.
1998: B A Th F Gabreëls; Dick F Swaab; D P de Kleijn; N G Seidah; JW van de Loo; Wim J M Van De Ven; G J Martens; Fijs W B van Leeuwen
Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect.
The Journal of clinical endocrinology and metabolism 1998;83(2):591-9.
1998: Philippe Debeer; Eric F P M Schoenmakers; Reinhilde Thoelen; Jean-Pierre Fryns; Wim J M Van De Ven
Physical mapping of the t(12;22) translocation breakpoints in a family with a complex type of 3/3'/4 synpolydactyly.
Cytogenetics and cell genetics 1998;81(3-4):229-34.
1997: Erik Jansen; Torik A Y Ayoubi; Sandra M P Meulemans; Wim J M Van De Ven
Regulation of human prohormone convertase 2 promoter activity by the transcription factor EGR-1.
The Biochemical journal 1997;328 ( Pt 1)():69-74.
1997: JW van de Loo; John W M Creemers; N A Bright; B D Young; Anton J M Roebroek; Wim J M Van De Ven
Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase.
The Journal of biological chemistry 1997;272(43):27116-23.
1997: IH Lemmens; J Merregaert; Wim J M Van De Ven; Koen Kas; Chang X Zhang; Sophie Giraud; Virginie Wautot; N Buisson; K De Witte; J Salandre; G Lenoir; Alain Calender; F Parente; Danielle Quincey; Anouk Courseaux; Georges F Carle; Patrick Gaudray; MJ de Wit; Cornelis J M Lips; Jo W M Höppener; S Khodaei; A L Grant; Günther Weber; Soili Kytölä; Rajesh V Thakker
Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.
Genomics 1997;44(1):94-100.
1997: Koen Kas; Eva Röijer; Marianne L Voz; Eef Meyen; Göran Stenman; Wim J M Van De Ven
A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands.
Genomics 1997;43(3):349-58.
1997: IH Lemmens; Wim J M Van De Ven; Koen Kas; Chang X Zhang; Sophie Giraud; Virginie Wautot; N Buisson; K De Witte; J Salandre; G Lenoir; Michel Pugeat; Alain Calender; F Parente; Danielle Quincey; Patrick Gaudray; MJ de Wit; Cornelis J M Lips; Jo W M Höppener; S Khodaei; A L Grant; Günther Weber; Soili Kytölä; Bin Tean Teh; Filip Farnebo; Rajesh V Thakker
Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.
Human molecular genetics 1997;6(7):1177-83.
1997: Erik Jansen; Sandra M P Meulemans; IC Orlans; Wim J M Van De Ven
The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3.
Genomics 1997;42(2):336-41.
1997: Jan Geurts; Eric F P M Schoenmakers; Wim J M Van De Ven
Molecular characterization of a complex chromosomal rearrangement in a pleomorphic salivary gland adenoma involving the 3'-UTR of HMGIC.
Cancer genetics and cytogenetics 1997;95(2):198-205.
1997: Eric F P M Schoenmakers; Wim J M Van De Ven
From chromosome aberrations to the high mobility group protein gene family: evidence for a common genetic denominator in benign solid tumor development.
Cancer genetics and cytogenetics 1997;95(1):51-8.
1997: J M Hernández; Eric F P M Schoenmakers; Paola Dal Cin; Lucienne Michaux; Wim J M Van De Ven; Herman Van Den Berghe
Molecular delineation of the commonly deleted segment in mature B-cell lymphoid neoplasias with deletion of 7q.
Genes, chromosomes & cancer 1997;18(2):147-50.
1997: Koen Kas; Marianne L Voz; Eva Röijer; AK Aström; Eef Meyen; Göran Stenman; Wim J M Van De Ven
Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.
Nature genetics 1997;15(2):170-4.
1997: Erik Jansen; Torik A Y Ayoubi; Sandra M P Meulemans; Wim J M Van De Ven
Cell type-specific protein-DNA interactions at the cAMP response elements of the prohormone convertase 1 promoter. Evidence for additional transactivators distinct from CREB/ATF family members.
The Journal of biological chemistry 1997;272(4):2500-8.
1997: Jan Geurts; Eric F P M Schoenmakers; Eva Röijer; Göran Stenman; Wim J M Van De Ven
Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland.
Cancer research 1997;57(1):13-7.
1996: Peter Groenen; E Garcia; P Debeer; koenraad devriendt; J P Fryns; Wim J M Van De Ven
Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia.
Genomics 1996;38(2):141-8.
1996: John W M Creemers; E F Usac; Nicholas A Bright; J W Van de Loo; E Jansen; Wim J M Van De Ven; John C Hutton
Identification of a transferable sorting domain for the regulated pathway in the prohormone convertase PC2.
The Journal of biological chemistry 1996;271(41):25284-91.
1996: P F Kools; Wim J M Van De Ven
Amplification of a rearranged form of the high-mobility group protein gene HMGIC in OsA-CI osteosarcoma cells.
Cancer genetics and cytogenetics 1996;91(1):1-7.
1996: Leonard Dode; Frank Wuytack; P F Kools; F Baba-Aissa; Luc Raeymaekers; F Briké; Wim J M Van De Ven; Rik Casteels; F Brik
cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene.
The Biochemical journal 1996;318 ( Pt 2)():689-99.
1996: Marleen MR Petit; R Mols; Eric F P M Schoenmakers; Nils Mandahl; Wim J M Van De Ven
LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family.
Genomics 1996;36(1):118-29.
1996: S Bol; S Wanschura; B Thode; U Deichert; Wim J M Van De Ven; S Bartnitzke; Jörn Bullerdiek
An endometrial polyp with a rearrangement of HMGI-C underlying a complex cytogenetic rearrangement involving chromosomes 2 and 12.
Cancer genetics and cytogenetics 1996;90(1):88-90.
1996: Koen Kas; V Lemahieu; Eef Meyen; Wim J M Van De Ven; Joseph Merregaert
Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation.
Genomics 1996;34(3):433-6.
1996: S Pittaluga; Torik A Y Ayoubi; Iwona Wlodarska; Michel Stul; Jean-Jacques Cassiman; Cristina Mecucci; Herman Van Den Berghe; Wim J M Van De Ven; Christiane De Wolf-Peeters
BCL-6 expression in reactive lymphoid tissue and in B-cell non-Hodgkin's lymphomas.
The Journal of pathology 1996;179(2):145-50.
1996: S Wanschura; B Kazmierczak; Y Pohnke; K Meyer-Bolte; S Bartnitzke; Wim J M Van De Ven; Jörn Bullerdiek
Transcriptional activation of HMGI-C in three pulmonary hamartomas each with a der(14)t(12;14) as the sole cytogenetic abnormality.
Cancer letters 1996;102(1-2):17-21.
1996: Nicole H M Senden; ED Timmer; J E Boers; Hilde Van de Velde; Anton J M Roebroek; Wim J M Van De Ven; Jos L V Broers; Frans C S Ramaekers
Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A.
European journal of cell biology 1996;69(3):197-213.
1996: S Wanschura; Eric F P M Schoenmakers; Christel Huysmans; S Bartnitzke; Wim J M Van De Ven; Jörn Bullerdiek
Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25.
Genomics 1996;32(2):298-300.
1996: Anton J M Roebroek; Torik A Y Ayoubi; Hilde Van de Velde; Eric F P M Schoenmakers; Ilse Pauli; Wim J M Van De Ven
Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.
Genomics 1996;32(2):191-9.
1996: Torik A Y Ayoubi; Wim J M Van De Ven
Regulation of gene expression by alternative promoters.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(4):453-60.
1996: B Kazmierczak; J Rosigkeit; S Wanschura; K Meyer-Bolte; Wim J M Van De Ven; K Kayser; B Krieghoff; H Kastendiek; S Bartnitzke; Jörn Bullerdiek
HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors.
Oncogene 1996;12(3):515-21.
1996: S Wanschura; Eric F P M Schoenmakers; Christel Huysmans; S Bartnitzke; Wim J M Van De Ven; J Bullrdiek
Mapping of the human HMG2 gene to 4q31.
Genomics 1996;31(2):264-5.
1996: J W van de Loo; John W M Creemers; Koen Kas; Anton J M Roebroek; Wim J M Van De Ven
Assignment of the human proprotein convertase gene PCSK5 to chromosome 9q21.3.
Cytogenetics and cell genetics 1996;75(4):227-9.
1996: Peter Groenen; E Garcia; R Thoelen; M Aly; Eric F P M Schoenmakers; koenraad devriendt; J P Fryns; Wim J M Van De Ven
Isolation of cosmids corresponding to the chromosome breakpoints of a de novo autosomal translocation, t(6;19)(p21;q13.1), in a patient with multicystic renal dysplasia.
Cytogenetics and cell genetics 1996;75(4):210-5.
1996: Torik A Y Ayoubi; Sandra M P Meulemans; Anton J M Roebroek; Wim J M Van De Ven
Production of recombinant proteins in Chinese hamster ovary cells overexpressing the subtilisin-like proprotein converting enzyme furin.
Molecular biology reports 1996;23(2):87-95.
1996: B Staats; Ulrich Bonk; S Wanschura; P Hanisch; Eric F P M Schoenmakers; Wim J M Van De Ven; S Bartnitzke; Jörn Bullerdiek
A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family.
Breast cancer research and treatment 1996;38(3):299-303.
1996: Koen Kas; Iwona Wlodarska; Eef Meyen; Herman Van Den Berghe; Wim J M Van De Ven
Assignment of the gene encoding human Krüppel-related zinc finger protein 4 (GLI4) to 8q24.3 by fluorescent in situ hybridization.
Cytogenetics and cell genetics 1996;72(4):297-8.
1996: S Wanschura; Gazanfer Belge; G Stenman; P Kools; Paola Dal Cin; Eric F P M Schoenmakers; Christel Huysmans; Herman Van Den Berghe; S Bartnitzke; Wim J M Van De Ven; Jörn Bullerdiek
Mapping of the translocation breakpoints of primary pleomorphic adenomas and lipomas within a common region of chromosome 12.
Cancer genetics and cytogenetics 1996;86(1):39-45.
1995: Koen Kas; Eric F P M Schoenmakers; Wim J M Van De Ven
Physical map location of the human carboxypeptidase M gene (CPM) distal to D12S375 and proximal to D12S8 at chromosome 12q15.
Genomics 1995;30(2):403-5.
1995: Eric F P M Schoenmakers; Jan Geurts; P F Kools; R Mols; Christel Huysmans; Jörn Bullerdiek; Herman Van Den Berghe; Wim J M Van De Ven
A 6-Mb yeast artificial chromosome contig and long-range physical map encompassing the region on chromosome 12q15 frequently rearranged in a variety of benign solid tumors.
Genomics 1995;29(3):665-78.
1995: C Rohen; Jörg Caselitz; C Stern; S Wanschura; Eric F P M Schoenmakers; Wim J M Van De Ven; S Bartnitzke; Jörn Bullerdiek
A hamartoma of the breast with an aberration of 12q mapped to the MAR region by fluorescence in situ hybridization.
Cancer genetics and cytogenetics 1995;84(1):82-4.
1995: Eric F P M Schoenmakers; S Wanschura; R Mols; Jörn Bullerdiek; Herman Van Den Berghe; Wim J M Van De Ven
Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours.
Nature genetics 1995;10(4):436-44.
1995: Erik Jansen; Torik A Y Ayoubi; Sandra M P Meulemans; Wim J M Van De Ven
Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements.
The Journal of biological chemistry 1995;270(25):15391-7.
1995: B Kazmierczak; S Wanschura; J Rosigkeit; K Meyer-Bolte; K Uschinsky; R Haupt; Eric F P M Schoenmakers; S Bartnitzke; Wim J M Van De Ven; Jörn Bullerdiek
Molecular characterization of 12q14-15 rearrangements in three pulmonary chondroid hamartomas.
Cancer research 1995;55(12):2497-9.
1995: Wim J M Van De Ven; Eric F P M Schoenmakers; S Wanschura; B Kazmierczak; P F Kools; Jan Geurts; S Bartnitzke; Herman Van Den Berghe; Jörn Bullerdiek
Molecular characterization of MAR, a multiple aberration region on human chromosome segment 12q13-q15 implicated in various solid tumors.
Genes, chromosomes & cancer 1995;12(4):296-303.
1995: Anton J M Roebroek; Torik A Y Ayoubi; John W M Creemers; Ilse Pauli; Wim J M Van De Ven
The Dfur2 gene of Drosophila melanogaster: genetic organization, expression during embryogenesis, and pro-protein processing activity of its translational product Dfurin2.
DNA and cell biology 1995;14(3):223-34.
1995: John W M Creemers; M Vey; W Schäfer; Torik A Y Ayoubi; Anton J M Roebroek; Hans-Dieter Klenk; Wolfgang Garten; Wim J M Van De Ven
Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum.
The Journal of biological chemistry 1995;270(6):2695-702.
1995: Torik A Y Ayoubi; Wim J M Van De Ven
A nonradioactive method to determine levels of in vitro transcription in nuclear extracts.
Analytical biochemistry 1995;225(1):190-2.
1995: Bart De Strooper; John W M Creemers; Dieder Moechars; Danny Huylebroeck; Wim J M Van De Ven; Fred Van Leuven; Herman Van Den Berghe
Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes.
Biochimica et biophysica acta 1995;1246(2):185-8.
1995: P F Kools; S Wanschura; Eric F P M Schoenmakers; Jan Geurts; R Mols; B Kazmierczak; Jörn Bullerdiek; Herman Van Den Berghe; Wim J M Van De Ven
Identification of the chromosome 12 translocation breakpoint region of a pleomorphic salivary gland adenoma with t(1;12)(p22;q15) as the sole cytogenetic abnormality.
Cancer genetics and cytogenetics 1995;79(1):1-7.
1995: S Wanschura; Y Hennig; U Deichert; Eric F P M Schoenmakers; Wim J M Van De Ven; S Bartnitzke; Jörn Bullerdiek
Molecular-cytogenetic refinement of the 12q14-->q15 breakpoint region affected in uterine leiomyomas.
Cytogenetics and cell genetics 1995;71(2):131-5.
1994: Nicole H M Senden; Hilde Van de Velde; Jos L V Broers; ED Timmer; Helma J H Kuijpers; Anton J M Roebroek; Wim J M Van De Ven; Frans C S Ramaekers
Subcellular localization and supramolecular organization of neuroendocrine-specific protein B (NSP-B) in small cell lung cancer.
European journal of cell biology 1994;65(2):341-53.
1994: Eric F P M Schoenmakers; R Mols; S Wanschura; P F Kools; Jan Geurts; S Bartnitzke; Jörn Bullerdiek; Herman Van Den Berghe; Wim J M Van De Ven
Identification, molecular cloning, and characterization of the chromosome 12 breakpoint cluster region of uterine leiomyomas.
Genes, chromosomes & cancer 1994;11(2):106-18.
1994: Anne Forus; P F Kools; Eric F P M Schoenmakers; Wim J M Van De Ven; Ola Myklebost
A long range restriction map spanning the myxoid liposarcoma breakpoint in the q13-14 region of human chromosome 12.
Human genetics 1994;94(3):259-64.
1994: Hilde Van de Velde; Nicole H M Senden; Tania Roskams; Jos L V Broers; Frans C S Ramaekers; Anton J M Roebroek; Wim J M Van De Ven
NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis.
Cancer research 1994;54(17):4769-76.
1994: Hilde Van de Velde; Anton J M Roebroek; Nicole H M Senden; Frans C S Ramaekers; Wim J M Van De Ven
NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum.
Journal of cell science 1994;107 ( Pt 9)():2403-16.
1994: Hilde Van de Velde; Anton J M Roebroek; F W van Leeuwen; Wim J M Van De Ven
Molecular analysis of expression in rat brain of NSP-A, a novel neuroendocrine-specific protein of the endoplasmic reticulum.
Brain research. Molecular brain research 1994;23(1-2):81-92.
1994: Torik A Y Ayoubi; John W M Creemers; Anton J M Roebroek; Wim J M Van De Ven
Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters.
The Journal of biological chemistry 1994;269(12):9298-303.
1994: Eric F P M Schoenmakers; P F Kools; R Mols; B Kazmierczak; S Bartnitzke; Jörn Bullerdiek; Paola Dal Cin; P J De Jong; Herman Van Den Berghe; Wim J M Van De Ven
Physical mapping of chromosome 12q breakpoints in lipoma, pleomorphic salivary gland adenoma, uterine leiomyoma, and myxoid liposarcoma.
Genomics 1994;20(2):210-22.
1994: P F Kools; Anton J M Roebroek; Hilde Van de Velde; Peter Marynen; Jörn Bullerdiek; Wim J M Van De Ven
Regional mapping of the human NSP gene to chromosome region 14q21-->q22 by fluorescence in situ hybridization analysis.
Cytogenetics and cell genetics 1994;66(1):48-50.
1994: Anton J M Roebroek; John W M Creemers; Torik A Y Ayoubi; Wim J M Van De Ven
Furin-mediated proprotein processing activity: involvement of negatively charged amino acid residues in the substrate binding region.
Biochimie 1994;76(3-4):210-6.
1994: Nicole H M Senden; Hilde Van de Velde; Jos L V Broers; ED Timmer; Anton J M Roebroek; Wim J M Van De Ven; Frans C S Ramaekers
Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1994;8():84-8.
1993: John W M Creemers; Paul J Groot-Kormelink; Anton J M Roebroek; K Nakayama; Wim J M Van De Ven
Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4.
FEBS letters 1993;336(1):65-9.
1993: Iwona Wlodarska; Eric F P M Schoenmakers; Koen Kas; Joseph Merregaert; V Lemahieu; U Weier; Herman Van Den Berghe; Wim J M Van De Ven
Molecular mapping of the chromosome 11 breakpoint of t(11;17)(q13;q21) in a t(11;14)(q13;q32)-positive B non-Hodgkin's lymphoma.
Genes, chromosomes & cancer 1993;8(4):224-9.
1993: John W M Creemers; Roland Siezen; Anton J M Roebroek; Torik A Y Ayoubi; Danny Huylebroeck; Wim J M Van De Ven
Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis.
The Journal of biological chemistry 1993;268(29):21826-34.
1993: Anton J M Roebroek; Hilde Van de Velde; A van Bokhoven; Jos L V Broers; Frans C S Ramaekers; Wim J M Van De Ven
Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product.
The Journal of biological chemistry 1993;268(18):13439-47.
1993: Anton J M Roebroek; John W M Creemers; Ilse Pauli; T Bogaert; Wim J M Van De Ven
Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene.
The EMBO journal 1993;12(5):1853-70.
1993: H F Schoenmakers; P F Kools; B Kazmierczak; Jörn Bullerdiek; U Claussen; B Horsthemke; Herman Van Den Berghe; Wim J M Van De Ven
Isolation of a somatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line.
Cytogenetics and cell genetics 1993;62(2-3):159-61.
1993: Wim J M Van De Ven; Anton J M Roebroek; H L Van Duijnhoven
Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.
Critical reviews in oncogenesis 1993;4(2):115-36.
1992: Anton J M Roebroek; John W M Creemers; Ilse Pauli; U Kurzik-Dumke; M Rentrop; E A Gateff; Jack Leunissen; Wim J M Van De Ven
Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif.
The Journal of biological chemistry 1992;267(24):17208-15.
1992: Manfred Jücker; Anton J M Roebroek; Josef Mautner; K Koch; Dirk Eick; Volker Diehl; Wim J M Van De Ven; Hans Tesch
Expression of truncated transcripts of the proto-oncogene c-fps/fes in human lymphoma and lymphoid leukemia cell lines.
Oncogene 1992;7(5):943-52.
1992: H L van Duijnhoven; E H Moors; A Groeneveld; ED Timmer; L F de Leij; S S Wagenaar; J M Polak; Wim J M Van De Ven
Monoclonal antibody MON-114: detection of a marker for neuroendocrine differentiation in human lung cancer.
Cancer letters 1992;63(1):61-6.
1992: John W M Creemers; Anton J M Roebroek; Wim J M Van De Ven
Expression in human lung tumor cells of the proprotein processing enzyme PC1/PC3. Cloning and primary sequence of a 5 kb cDNA.
FEBS letters 1992;300(1):82-8.
1992: H L van Duijnhoven; John W M Creemers; M G Kranenborg; ED Timmer; A Groeneveld; Ans M W van den Ouweland; Anton J M Roebroek; Wim J M Van De Ven
Development and characterization of a panel of monoclonal antibodies against the novel subtilisin-like proprotein processing enzyme furin.
Hybridoma 1992;11(1):71-86.
1992: A van Bokhoven; H L van Duijnhoven; Manfred Jücker; Anton J M Roebroek; Wim J M Van De Ven
Development and characterization of a panel of monoclonal antibodies against the catalytic domain of the human fes proto-oncogene product.
Molecular biology reports 1992;16(1):17-25.
1992: H L van Duijnhoven; Wijnand Helfrich; Lou de Leij; Anton J M Roebroek; Wim J M Van De Ven; K Healey; A Culverwell; R J Rossell; JT Kemshead; K Patel
Splicing of the VASE exon of neural cell adhesion molecule (NCAM) in human small-cell lung carcinoma (SCLC).
International journal of cancer. Journal international du cancer 1992;50(1):118-23.
1992: J L van Duijnhoven; Joost Schalkwijk; M H Kranenborg; Ivonne M J J van Vlijmen-Willems; A Groeneveld; Piet E J van Erp; ED Timmer; Gys J de Jongh; Wim J M Van De Ven
MON-150, a versatile monoclonal antibody against involucrin: characterization and applications.
Archives of dermatological research 1992;284(3):167-72.
1991: H L van Duijnhoven; M C Verschuren; ED Timmer; P M Vissers; A Groeneveld; Torik A Y Ayoubi; Ans M W van den Ouweland; Wim J M Van De Ven
Application of recombinant DNA technology in epitope mapping and targeting. Development and characterization of a panel of monoclonal antibodies against the 7B2 neuroendocrine protein.
Journal of immunological methods 1991;142(2):187-98.
1991: Anton J M Roebroek; Ilse Pauli; Y Zhang; Wim J M Van De Ven
cDNA sequence of a Drosophila melanogaster gene, Dfur1, encoding a protein structurally related to the subtilisin-like proprotein processing enzyme furin.
FEBS letters 1991;289(2):133-7.
1991: Wim J M Van De Ven; John W M Creemers; Anton J M Roebroek
Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway.
Enzyme 1991;45(5-6):257-70.
1990: Wim J M Van De Ven; Jan Voorberg; R Fontijn; H Pannekoek; Ans M W van den Ouweland; H L van Duijnhoven; Anton J M Roebroek; Roland Siezen
Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes.
Molecular biology reports 1990;14(4):265-75.
1990: K Koch; Manfred Jücker; M Michels; Wim J M Van De Ven; Hans Tesch
Polymorphism at the FES locus detected by PFGE.
Nucleic acids research 1990;18(19):5918.
1990: Torik A Y Ayoubi; H L van Duijnhoven; Wim J M Van De Ven; Bruce G Jenks; Eric W Roubos; Gerard J M Martens
The neuroendocrine polypeptide 7B2 is a precursor protein.
The Journal of biological chemistry 1990;265(26):15644-7.
1990: Ans M W van den Ouweland; H L van Duijnhoven; G D Keizer; L C Dorssers; Wim J M Van De Ven
Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2.
Nucleic acids research 1990;18(3):664.
1989: H L van Duijnhoven; Torik A Y Ayoubi; ED Timmer; A A Braks; Anton J M Roebroek; Gerard J M Martens; Wim J M Van De Ven
Development of a monoclonal antibody against recombinant neuroendocrine 7B2 protein.
FEBS letters 1989;255(2):372-6.
1989: Ans M W van den Ouweland; J J Van Groningen; Anton J M Roebroek; C Onnekink; Wim J M Van De Ven
Nucleotide sequence analysis of the human fur gene.
Nucleic acids research 1989;17(17):7101-2.
1989: Anton J M Roebroek; Gerard J M Martens; A J Duits; Jack A Schalken; A van Bokhoven; S S Wagenaar; Wim J M Van De Ven
Differential expression of the gene encoding the novel pituitary polypeptide 7B2 in human lung cancer cells.
Cancer research 1989;49(15):4154-8.
1989: Ans M W van den Ouweland; H L Van Duijnhoven; K A Deichmann; J J Van Groningen; Lou de Leij; Wim J M Van De Ven
Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes.
Nucleic acids research 1989;17(10):3829-43.
1989: Anton J M Roebroek; M R Dehaen; A van Bokhoven; Gerard J M Martens; P Marÿnen; H van den Berghe; Wim J M Van De Ven
Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization.
Cytogenetics and cell genetics 1989;50(2-3):158-60.
1988: Hans Tesch; K Olek; J Geisel; Wim J M Van De Ven; Manfred Jücker
RFLP of the human c-fes proto-oncogene.
Nucleic acids research 1988;16(9):4193.
1988: Jack A Schalken; Ans M W van den Ouweland; F M Debruijne; Herbert F M Karthaus; Wim J M Van De Ven
Oncogenes and urological malignancies: implications for the future.
Urological research 1988;16(5):333-9.
1988: Jacques J M Janssen; Wim J M Van De Ven; W A van Groningen-Luyben; J Roosien; Just M Vlak; Willem J De Grip
Synthesis of functional bovine opsin in insect cells under control of the baculovirus polyhedrin promoter.
Molecular biology reports 1988;13(2):65-71.
1987: Jack A Schalken; Anton J M Roebroek; P P Oomen; S S Wagenaar; F M Debruyne; Henri P J Bloemers; Wim J M Van De Ven
fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas.
The Journal of clinical investigation 1987;80(6):1545-9.
1987: J J Van Groningen; Ans M W van den Ouweland; J S Verbeek; Annemiete W C M van der Kemp; Henri P J Bloemers; Wim J M Van De Ven
Structural analysis of a variant clone of Snyder-Theilen feline sarcoma virus.
Virus research 1987;8(4):349-61.
1987: Anton J M Roebroek; Jack A Schalken; C Onnekink; Henri P J Bloemers; Wim J M Van De Ven
Structure of the feline c-fes/fps proto-oncogene: genesis of a retroviral oncogene.
Journal of virology 1987;61(6):2009-16.
1987: Ans M W van den Ouweland; J J van Groningen; P J Hendriksen; Henri P J Bloemers; Wim J M Van De Ven
Nucleotide sequence of the DNA region immediately upstream of the human c-sis proto-oncogene.
Nucleic acids research 1987;15(10):4349.
1987: Ans M W van den Ouweland; J J Van Groningen; Jack A Schalken; H W Van Neck; Henri P J Bloemers; Wim J M Van De Ven
Genetic organization of the c-sis transcription unit.
Nucleic acids research 1987;15(3):959-70.
1987: Herbert F M Karthaus; M J G Bussemakers; Jack A Schalken; K H Kurth; W F J Feitz; F M Debruyne; Henri P J Bloemers; Wim J M Van De Ven
Expression of proto-oncogenes in xenografts of human renal cell carcinomas.
Urological research 1987;15(6):349-53.
1986: Anton J M Roebroek; Jack A Schalken; Jack Leunissen; C Onnekink; Henri P J Bloemers; Wim J M Van De Ven
Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.
The EMBO journal 1986;5(9):2197-202.
1986: Anton J M Roebroek; Jack A Schalken; M J G Bussemakers; H van Heerikhuizen; C Onnekink; F M Debruyne; Henri P J Bloemers; Wim J M Van De Ven
Characterization of human c-fes/fps reveals a new transcription unit (fur) in the immediately upstream region of the proto-oncogene.
Molecular biology reports 1986;11(2):117-25.
1986: Herbert F M Karthaus; Jack A Schalken; W F J Feitz; F M Debruyne; Peter de Haan; Henri P J Bloemers; Wim J M Van De Ven
Expression of the human fes cellular oncogene in renal cell tumors.
Urological research 1986;14(3):123-7.
1985: Anton J M Roebroek; Jack A Schalken; J S Verbeek; Ans M W van den Ouweland; C Onnekink; Henri P J Bloemers; Wim J M Van De Ven
The structure of the human c-fes/fps proto-oncogene.
The EMBO journal 1985;4(11):2897-903.
1985: J S Verbeek; H van Heerikhuizen; B E de Pauw; C Haanen; Henri P J Bloemers; Wim J M Van De Ven
A hereditary abnormal c-fms proto-oncogene in a patient with acute lymphocytic leukaemia and congenital hypothyroidism.
British journal of haematology 1985;61(1):135-8.
1985: J S Verbeek; P de Ruyter; Henri P J Bloemers; Wim J M Van De Ven
Molecular cloning and characterization of feline cellular genetic sequences homologous to the oncogene of the McDonough strain of feline sarcoma virus.
Virology 1985;141(2):322-7.
1985: J S Verbeek; Anton J M Roebroek; Ans M W van den Ouweland; Henri P J Bloemers; Wim J M Van De Ven
Human c-fms proto-oncogene: comparative analysis with an abnormal allele.
Molecular and cellular biology 1985;5(2):422-6.
1985: J S Verbeek; Ans M W van den Ouweland; Jack A Schalken; Anton J M Roebroek; C Onnekink; Henri P J Bloemers; Wim J M Van De Ven
Molecular cloning of the feline c-fes proto-oncogene and construction of a chimeric transforming gene.
Gene 1985;35(1-2):33-43.