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Marc van de Wetering

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Jarom Heijmans; Daniël W Hommes; Liudmila L Kodach; Bon-Kyoung Koo; Amy S Lee; A Mieke Mommaas; Vanesa Muncan; Jos J M Onderwater; Adrienne W Paton; James C Paton; Sanne L Rosekrans; Marc van de Wetering; Hans Clevers; Marc Ferrante; James C H Hardwick; Jooske F van Lidth de Jeude; Mattheus C B Wielenga; Gijs R van den Brink
ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response.
Meritxell Huch; Vivian S W Li; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Johan H van Es; Robert G J Vries; Craig Dorrell; Milton J Finegold; Markus Grompe; Annelise Haft; Karien Hamer; Sylvia F Boj; Hans Clevers
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Johan H van Es; Alexander van Oudenaarden; Laura Zeinstra; Annie Ng Yee Nee; Nick Barker; Alex Gregorieff; Jeroen Korving; Anna Lyubimova; Anton C M Martens; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Maaike van den Born; Hans Clevers
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.

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All Publications

2013: Jarom Heijmans; Daniël W Hommes; Liudmila L Kodach; Bon-Kyoung Koo; Amy S Lee; A Mieke Mommaas; Vanesa Muncan; Jos J M Onderwater; Adrienne W Paton; James C Paton; Sanne L Rosekrans; Marc van de Wetering; Hans Clevers; Marc Ferrante; James C H Hardwick; Jooske F van Lidth de Jeude; Mattheus C B Wielenga; Gijs R van den Brink
ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response.
Cell reports 2013;3(4):1128-39.
2013: Meritxell Huch; Vivian S W Li; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Johan H van Es; Robert G J Vries; Craig Dorrell; Milton J Finegold; Markus Grompe; Annelise Haft; Karien Hamer; Sylvia F Boj; Hans Clevers
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Nature 2013;494(7436):247-50.
2012: Johan H van Es; Alexander van Oudenaarden; Laura Zeinstra; Annie Ng Yee Nee; Nick Barker; Alex Gregorieff; Jeroen Korving; Anna Lyubimova; Anton C M Martens; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Maaike van den Born; Hans Clevers
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.
Nature cell biology 2012;14(10):1099-104.
2012: Nick Barker; Meritxell Huch; Pekka Kujala; Marc Leushacke; Annie Ng; Peter J Peters; Richard Poulsom; Maarten B Rookmaaker; Hugo Snippert; Shawna Tan; Marc van de Wetering; Johan H van Es; Marianne C Verhaar; Hans Clevers
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.
Cell reports 2012;2(3):540-52.
2012: Bon-Kyoung Koo; Teck Y Low; Madelon M Maurice; shabaz mohammed; Maureen Spit; Daniel E Stange; Marc van de Wetering; Johan H van Es; Albert J R Heck; Ingrid Jordens; Hans Clevers
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Nature 2012;488(7413):665-9.
2012: Arnout G Schepers; Hugo J Snippert; Daniel E Stange; Marc van de Wetering; Maaike van den Born; Johan H van Es; Hans Clevers
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.
Science (New York, N.Y.) 2012;337(6095):730-5.
2011: Wim de Lau; Daniele Guardavaccaro; Andrea Haegebarth; Albert J R Heck; Bon-Kyoung Koo; Pekka Kujala; Vivian S W Li; Teck Y Low; shabaz mohammed; Yasuaki Mohri; Katsuhiko Nishimori; Peter J Peters; Richard B M Schasfoort; Daniel E Stange; Hans Teunissen; Marc van de Wetering; Johan E van Es; Nick Barker; Hans Clevers
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Nature 2011;476(7360):293-7.
2011: Arnout G Schepers; Robert G J Vries; Maaike van den Born; Marc van de Wetering; Hans Clevers
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes.
The EMBO journal 2011;30(6):1104-9.
2011: Toshiro Sato; Johan H van Es; Hugo J Snippert; Daniel E Stange; Robert G Vries; Maaike van den Born; Nick Barker; Noah F Shroyer; Marc van de Wetering; Hans Clevers
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Nature 2011;469(7330):415-8.
2010: Hugo J Snippert; Andrea Haegebarth; Maria Kasper; Viljar Jaks; Johan H van Es; Nick Barker; Marc van de Wetering; Maaike van den Born; Harry Begthel; Robert G Vries; Daniel E Stange; Rune Toftgård; Hans Clevers
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Science (New York, N.Y.) 2010;327(5971):1385-9.
2010: Nick Barker; Meritxell Huch; Pekka Kujala; Marc van de Wetering; Hugo J Snippert; Johan H van Es; Toshiro Sato; Daniel E Stange; Harry Begthel; Maaike van den Born; Esther Danenberg; Stieneke van den Brink; Jeroen Korving; Arie Abo; Peter J Peters; Nick Wright; Richard Poulsom; Hans Clevers
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
Cell stem cell 2010;6(1):25-36.
2010: Michal Mokry; Pantelis Hatzis; Ewart de Bruijn; Jan Koster; Rogier Versteeg; Jurian Schuijers; Marc van de Wetering; Victor Guryev; Hans Clevers; Edwin Cuppen
Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.
PloS one 2010;5(11):e15092.
2009: Laurens G van der Flier; Andrea Haegebarth; Daniel E Stange; Marc van de Wetering; Hans Clevers
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.
Gastroenterology 2009;137(1):15-7.
2009: Toshiro Sato; Robert G Vries; Hugo J Snippert; Marc van de Wetering; Nick Barker; Daniel E Stange; Johan H van Es; Arie Abo; Pekka Kujala; Peter J Peters; Hans Clevers
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Nature 2009;459(7244):262-5.
2009: Laurens G van der Flier; Marielle E van Gijn; Pantelis Hatzis; Pekka Kujala; Andrea Haegebarth; Daniel E Stange; Harry Begthel; Maaike van den Born; Victor Guryev; Irma Oving; Johan H van Es; Nick Barker; Peter J Peters; Marc van de Wetering; Hans Clevers
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
Cell 2009;136(5):903-12.
2009: Nick Barker; Rachel A Ridgway; Johan H van Es; Marc van de Wetering; Harry Begthel; Maaike van den Born; Esther Danenberg; Alan R Clarke; Owen J Sansom; Hans Clevers
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nature 2009;457(7229):608-11.
2008: Nick Barker; Marc van de Wetering; Hans Clevers
The intestinal stem cell.
Genes & development 2008;22(14):1856-64.
2007: Laurens G Van der Flier; Jacob Sabates Bellver; Irma Oving; Andrea Haegebarth; Mariagrazia De Palo; Marcello Anti; Marielle E van Gijn; Saskia Suijkerbuijk; Marc van de Wetering; Giancarlo Marra; Hans Clevers
The Intestinal Wnt/TCF Signature.
Gastroenterology 2007;132(2):628-32.
2005: Owen J Sansom; Karen R Reed; Marc van de Wetering; Vanesa Muncan; Douglas J Winton; Hans Clevers; Alan R Clarke
Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.
The Journal of biological chemistry 2005;280(31):28463-7.
2004: Ngoc Hang Le; Paola van der Bent - Klootwijk; Gerwin Huls; Marc van de Wetering; Mahmoud Loghman-Adham; Albert C M Ong; James P Calvet; Hans Clevers; Martijn H Breuning; Hans van Dam; Dorien J M Peters
Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected.
The Journal of biological chemistry 2004;279(26):27472-81.
2004: Linda Smit; Annette F Baas; Jeroen Kuipers; Hendrik Korswagen; Marc van de Wetering; Hans Clevers
Wnt activates the Tak1/Nemo-like kinase pathway.
The Journal of biological chemistry 2004;279(17):17232-40.
2003: Marc van de Wetering; Irma Oving; Vanesa Muncan; Menno Tjon Pon Fong; Helen Brantjes; Dik van Leenen; Frank C P Holstege; Thijn R Brummelkamp; Reuven Agami; Hans Clevers
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.
EMBO reports 2003;4(6):609-15.
2002: Eduard Batlle; Dr. Jeffrey Henderson; Harry Beghtel; Maaike van den Born; Elena Sancho; Gerwin Huls; Jan Meeldijk; Jennifer Robertson; Marc van de Wetering; Tony Pawson; Hans Clevers
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.
Cell 2002;111(2):251-63.
2002: Marc van de Wetering; Elena Sancho; Cornelis Verweij; Wim de Lau; Irma Oving; Adam F L Hurlstone; Karin van der Horn; Eduard Batlle; Damien Y M Coudreuse; Anna-Pavlina G Haramis; Menno Tjon-Pon-Fong; Petra Moerer; Maaike van den Born; Gwen Soete; Steven T Pals; Martin Eilers; Rene Medema; Hans Clevers
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
Cell 2002;111(2):241-50.
2002: Mascha van Noort; Marc van de Wetering; Hans Clevers
Identification of two novel regulated serines in the N terminus of beta-catenin.
Experimental cell research 2002;276(2):264-72.
2002: Marc van de Wetering; Wim de Lau; Hans Clevers
WNT signaling and lymphocyte development.
Cell 2002;109 Suppl():S13-9.
2001: Helen Brantjes; J Roose; Marc van de Wetering; Hans Clevers
All Tcf HMG box transcription factors interact with Groucho-related co-repressors.
Nucleic acids research 2001;29(7):1410-9.
2001: Marc van de Wetering; Nick Barker; IC Harkes; Michiel van der Heyden; N J Dijk; Antoinette Hollestelle; Jan G M Klijn; Hans Clevers; Mieke Schutte
Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.
Cancer research 2001;61(1):278-84.
2000: Moniek van Beest; Dennis Dooijes; Marc van de Wetering; Søren Kjaerulff; Alexandre Bonvin; Olaf Nielsen; Hans Clevers
Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs.
The Journal of biological chemistry 2000;275(35):27266-73.
1999: Johan H van Es; C Kirkpatrick; Marc van de Wetering; M Molenaar; A Miles; J Kuipers; Olivier Destrée; Mark Peifer; Hans Clevers
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Current biology : CB 1999;9(2):105-8.
1998: J Roose; M Molenaar; J Peterson; J Hurenkamp; Helen Brantjes; Petra Moerer; Marc van de Wetering; Olivier Destrée; Hans Clevers
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.
Nature 1998;395(6702):608-12.
1998: Dennis Dooijes; Moniek van Beest; Marc van de Wetering; G Boulanger; Tamara Jones; Hans Clevers; Mark A Mortin
Genomic organization of the segment polarity gene pan in Drosophila melanogaster.
Molecular & general genetics : MGG 1998;258(1-2):45-52.
1997: Hans Clevers; Marc van de Wetering
TCF/LEF factor earn their wings.
Trends in genetics : TIG 1997;13(12):485-9.
1997: Marc van de Wetering; R Cavallo; Dennis Dooijes; Moniek van Beest; Johan H van Es; Joseph Loureiro; A Ypma; Deborah A Hursh; Tamara Jones; Amy Bejsovec; Mark Peifer; Mark A Mortin; Hans Clevers
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.
Cell 1997;88(6):789-99.
1996: M Molenaar; Marc van de Wetering; M Oosterwegel; J Peterson-Maduro; S Godsave; V Korinek; J Roose; Olivier Destrée; Hans Clevers
XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.
Cell 1996;86(3):391-9.
1996: Marco W Schilham; M A Oosterwegel; Petra Moerer; J Ya; Piet A J de Boer; Marc van de Wetering; S Verbeek; Wouter H Lamers; A M Kruisbeek; A Cumano; Hans Clevers
Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4.
Nature 1996;380(6576):711-4.
1996: Marc van de Wetering; J Castrop; V Korinek; Hans Clevers
Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties.
Molecular and cellular biology 1996;16(3):745-52.
1995: J Castrop; Dick F van Wichen; M Koomans-Bitter; Marc van de Wetering; Roel A de Weger; J van Dongen; Hans Clevers
The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.
Blood 1995;86(8):3050-9.
1995: S Verbeek; D Izon; Frans M A Hofhuis; Els C Robanus-Maandag; Hein te Riele; Marc van de Wetering; M Oosterwegel; Anne Wilson; H Robson MacDonald; Hans Clevers
An HMG-box-containing T-cell factor required for thymocyte differentiation.
Nature 1995;374(6517):70-4.
1993: Dennis Dooijes; Marc van de Wetering; L Knippels; Hans Clevers
The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein.
The Journal of biological chemistry 1993;268(33):24813-7.
1993: Marc van de Wetering; M Oosterwegel; K van Norren; Hans Clevers
Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.
The EMBO journal 1993;12(10):3847-54.
1993: M Oosterwegel; Marc van de Wetering; Hans Clevers
HMG box proteins in early T-cell differentiation.
Thymus 1993;22(2):67-81.
1993: L van Houte; A van Oers; Marc van de Wetering; Dennis Dooijes; R Kaptein; Hans Clevers
The sequence-specific high mobility group 1 box of TCF-1 adopts a predominantly alpha-helical conformation in solution.
The Journal of biological chemistry 1993;268(24):18083-7.
1993: M Oosterwegel; Marc van de Wetering; J Timmerman; A Kruisbeek; O Destree; F Meijlink; Hans Clevers
Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis.
Development (Cambridge, England) 1993;118(2):439-48.
1993: Marco W Schilham; M van Eijk; Marc van de Wetering; Hans Clevers
The murine Sox-4 protein is encoded on a single exon.
Nucleic acids research 1993;21(8):2009.
1993: Marc van de Wetering; Hans Clevers
Sox 15, a novel member of the murine Sox family of HMG box transcription factors.
Nucleic acids research 1993;21(7):1669.
1992: Marc van de Wetering; Hans Clevers
Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix.
The EMBO journal 1992;11(8):3039-44.
1992: Marc van de Wetering; M Oosterwegel; F Holstege; D Dooyes; R Suijkerbuijk; A Geurts van Kessel; Hans Clevers
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
The Journal of biological chemistry 1992;267(12):8530-6.
1991: M A Oosterwegel; Marc van de Wetering; F C Holstege; H M Prosser; M J Owen; H C Clevers
TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers.
International immunology 1991;3(11):1189-92.
1991: Boudewijn M T Burgering; R H Medema; J Antonie Maassen; Marc van de Wetering; Alex J van der Eb; F McCormick; Johannes L Bos
Insulin stimulation of gene expression mediated by p21ras activation.
The EMBO journal 1991;10(5):1103-9.
1991: M Oosterwegel; Marc van de Wetering; Dennis Dooijes; L Klomp; A Winoto; K Georgopoulos; F Meijlink; Hans Clevers
Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.
The Journal of experimental medicine 1991;173(5):1133-42.
1991: Marc van de Wetering; M Oosterwegel; Dennis Dooijes; Hans Clevers
Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.
The EMBO journal 1991;10(1):123-32.