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Wim van den Berg

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Theo S Plantinga; Georg Schett; Wim B van den Berg; Annette H M Van Der Helm-Van Mil; Jos W M van der Meer; Piet L van Riel; Jochen Zwerina; Jaap Fransen; Monique M A Helsen; Rachel Knevel; Mihai G Netea; Leo A B Joosten
Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis.
B T van den Brand; E A Vermeij; Wim B van den Berg; Shahla Abdollahi-Roodsaz; Onno J Arntz; Miranda B Bennink; C V Rothlin; Fons A J van de Loo
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis.
Lilyanne C Grevers; Wim B van den Berg; Teun J de Vries; Vincent Everts; Sjef Verbeek; Peter L E M van Lent
Immune complex-induced inhibition of osteoclastogenesis is mediated via activating but not inhibitory Fcγ receptors on myeloid precursor cells.

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2013: Theo S Plantinga; Georg Schett; Wim B van den Berg; Annette H M Van Der Helm-Van Mil; Jos W M van der Meer; Piet L van Riel; Jochen Zwerina; Jaap Fransen; Monique M A Helsen; Rachel Knevel; Mihai G Netea; Leo A B Joosten
Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis.
Rheumatology (Oxford, England) 2013;52(5):806-14.
2013: B T van den Brand; E A Vermeij; Wim B van den Berg; Shahla Abdollahi-Roodsaz; Onno J Arntz; Miranda B Bennink; C V Rothlin; Fons A J van de Loo
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis.
Arthritis and rheumatism 2013;65(3):671-80.
2013: Lilyanne C Grevers; Wim B van den Berg; Teun J de Vries; Vincent Everts; Sjef Verbeek; Peter L E M van Lent
Immune complex-induced inhibition of osteoclastogenesis is mediated via activating but not inhibitory Fcγ receptors on myeloid precursor cells.
Annals of the rheumatic diseases 2013;72(2):278-85.
2013: Wouter Hofkens; Rik Schelbergen; Gert Storm; Wim B van den Berg; Peter L van Lent
Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation.
PloS one 2013;8(2):e54016.
2013: Ben T van den Brand; Eline A Vermeij; Claire E J Waterborg; Wim B van den Berg; Onno J Arntz; Miranda B Bennink; Michael Kracht; Fons A J van de Loo
Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis.
PloS one 2013;8(2):e55356.
2013: D F G Remst; J M Snabel; R Stoop; Wim B van den Berg; R A Bank; Esmeralda N Blaney Davidson; Arjen B Blom; Elly L Vitters; Peter van der Kraan
Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2013;21(1):157-64.
2012: Bas Heinhuis; Mihai G Netea; Wim B van den Berg; Charles A Dinarello; Leo A B Joosten
Interleukin-32: a predominantly intracellular proinflammatory mediator that controls cell activation and cell death.
Cytokine 2012;60(2):321-7.
2012: Fons A J van de Loo; Ben van den Brand; Peter M van der Kraan; Sharon Veenbergen; Onno J Arntz; Miranda B Bennink; Esmeralda Blaney-Davidson; Henk M van Beuningen; Wim B van den Berg
Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function.
Arthritis and rheumatism 2012;64(10):3313-23.
2012: Marije I Koenders; Renoud J Marijnissen; Fons A J van de Loo; Wim B van den Berg; Shahla Abdollahi-Roodsaz; Franco E Di Padova; John Dulos; Leo A B Joosten; Annemieke M H Boots
T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization.
Arthritis and rheumatism 2012;64(6):1762-70.
2012: Shahla Abdollahi-Roodsaz; Onno J Arntz; Monique M A Helsen; Leo A B Joosten; Marije I Koenders; Nozomi Takahashi; Fons A J van de Loo; Liduine Van Den Bersselaar; Birgitte Walgreen; Wim B van den Berg
Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice.
Arthritis and rheumatism 2012;64(6):1838-47.
2012: P L E M van Lent; Thomas Vogl; Arjen B Blom; Hans Cats; Floris P J G Lafeber; Willem F Lems; Johannes Roth; Rik F P Schelbergen; Annet W Slöetjes; Wim B van den Berg
Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis.
Arthritis and rheumatism 2012;64(5):1466-76.
2012: Rik F P Schelbergen; B Wim Schreurs; Annet W Slöetjes; Wim B van den Berg; Martijn H J van den Bosch; Shahla Abdollahi-Roodsaz; Arjen B Blom; John S Mort; Johannes Roth; Thomas Vogl; P L E M van Lent
Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4.
Arthritis and rheumatism 2012;64(5):1477-87.
2012: Peter van der Kraan; Wim B van den Berg
Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012;20(3):223-32.
2012: Bas Heinhuis; Marije I Koenders; Mihai G Netea; Wim B van den Berg; Charles A Dinarello; Leo A B Joosten
Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.
The Journal of biological chemistry 2012;287(8):5733-43.
2012: Renoud J Marijnissen; Mihai G Netea; Frank van de Veerdonk; Annemieke M H Boots; John Dulos; Leo A B Joosten; Marije I Koenders; Wim B van den Berg
Exposure to Candida albicans polarizes a T-cell driven arthritis model towards Th17 responses, resulting in a more destructive arthritis.
PloS one 2012;7(6):e38889.
2012: Mark Wenink; P Garside; A M Platt; T R D J Radstake; K C M Santegoets; Wim B van den Berg; P L C M van Riel; I B McInnes
Abatacept modulates proinflammatory macrophage responses upon cytokine-activated T cell and Toll-like receptor ligand stimulation.
Annals of the rheumatic diseases 2012;71(1):80-3.
2011: Sharon Veenbergen; Wim B van den Berg; Alsya J Affandi; Onno J Arntz; Miranda B Bennink; Natacha Bessis; Jérôme Biton; Fons A J van de Loo
A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis.
Annals of the rheumatic diseases 2011;70(12):2167-75.
2011: K C M Santegoets; L van Bon; Wim B van den Berg; Mark Wenink; T R D J Radstake
Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?
FEBS letters 2011;585(23):3660-6.
2011: Lidia Ibáñez; Marije I Koenders; Nuria Maicas; Wim B van den Berg; Maria José Alcaraz; José Ramón Caeiro; David Guede; M Luisa Ferrándiz
Up-regulation of the inflammatory response by ovariectomy in collagen-induced arthritis. effects of tin protoporphyrin IX.
Inflammation 2011;34(6):585-96.
2011: Mark Wenink; John Butcher; Femke G M Lamers-Karnebeek; Iain B McInnes; Kim C M Santegoets; Lenny van Bon; Wim B van den Berg; Piet L C M van Riel; Timothy R D J Radstake
Impaired dendritic cell proinflammatory cytokine production in psoriatic arthritis.
Arthritis and rheumatism 2011;63(11):3313-22.
2011: Renoud J Marijnissen; Cheryl Nickerson-Nutter; Ruben L Smeets; Mark H T Stappers; Annemieke M H Boots; Leo A B Joosten; Marije I Koenders; Wim B van den Berg
Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation.
Arthritis and rheumatism 2011;63(10):2939-48.
2011: Wouter Hofkens; K C A M Nabbe; Gerard J Pesman; Gert Storm; Fred C Sweep; Wim B van den Berg; Jolanda M van den Hoven; Peter L van Lent
Safety of glucocorticoids can be improved by lower yet still effective dosages of liposomal steroid formulations in murine antigen-induced arthritis: comparison of prednisolone with budesonide.
International journal of pharmaceutics 2011;416(2):493-8.
2011: W Hofkens; Gert Storm; Wim B van den Berg; P L van Lent
Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritis.
International journal of pharmaceutics 2011;416(2):486-92.
2011: Nuria Maicas; Wim B van den Berg; Rita Brines; Antonio Cuadrado; M Luisa Ferrándiz; Lidia Ibáñez; Marije I Koenders; Maria José Alcaraz
Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease.
Antioxidants & redox signaling 2011;15(4):889-901.
2011: Jeroen Geurts; Eline A Vermeij; Dirk Pohlers; Onno J Arntz; Raimund W Kinne; Wim B van den Berg; Fons A J van de Loo
A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts.
Annals of the rheumatic diseases 2011;70(7):1311-9.
2011: Jeroen Geurts; Michael Kracht; Shahla Abdollahi-Roodsaz; Onno J Arntz; Wim B van den Berg; Ben T van den Brand; Alexander Wolf; Fons A J van de Loo
Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts.
Rheumatology (Oxford, England) 2011;50(7):1216-25.
2011: Wouter Hofkens; Pieter J M Leenen; Gert Storm; Wim B van den Berg; Teun J de Vries; Vincent Everts; Lilyanne C Grevers; Birgitte Walgreen; P L E M van Lent
Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis.
Journal of controlled release : official journal of the Controlled Release Society 2011;152(3):363-9.
2011: Frank van de Veerdonk; Bernard Lauwerys; Renoud J Marijnissen; Kim Timmermans; Franco E Di Padova; Marije I Koenders; Ilse Gutierrez-Roelens; Patrick Durez; Mihai G Netea; Jos W M van der Meer; Wim B van den Berg; Leo A B Joosten
The anti-CD20 antibody rituximab reduces the Th17 cell response.
Arthritis and rheumatism 2011;63(6):1507-16.
2011: Lilyanne C Grevers; Teun J de Vries; Thomas Vogl; Shahla Abdollahi-Roodsaz; Annet Sloetjes; Pieter J M Leenen; Johannes Roth; Vincent Everts; Wim B van den Berg; P L E M van Lent
S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis.
Arthritis and rheumatism 2011;63(5):1365-75.
2011: Wim B van den Berg
Osteoarthritis year 2010 in review: pathomechanisms.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2011;19(4):338-41.
2011: Bas Heinhuis; Marije I Koenders; Piet L van Riel; Fons A J van de Loo; Charles A Dinarello; Mihai G Netea; Wim B van den Berg; Leo A B Joosten
Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade.
Annals of the rheumatic diseases 2011;70(4):660-7.
2011: Bas Heinhuis; Marije I Koenders; Fons A J van de Loo; Mihai G Netea; Wim B van den Berg; Leo A B Joosten
Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(12):4962-7.
2011: Shahla Abdollahi-Roodsaz; Fons A J van de Loo; Wim B van den Berg
Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium.
Arthritis research & therapy 2011;13(2):105.
2010: Rinke Stienstra; Leo A B Joosten; Tim Koenen; Berry van Tits; Janna A van Diepen; Sjoerd van den Berg; Patrick C N Rensen; Peter J Voshol; Giamila Fantuzzi; Anneke Hijmans; Sander Kersten; Michael Müller; Wim B van den Berg; Nico van Rooijen; Martin Wabitsch; Bart Jan Kullberg; Jos W M van der Meer; Thirumala Kanneganti; Cees J Tack; Mihai G Netea
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.
Cell metabolism 2010;12(6):593-605.
2010: P L E M van Lent; Lilyanne C Grevers; Rik Schelbergen; Arjen Blom; Jeroen Geurts; Annet Sloetjes; Thomas Vogl; Johannes Roth; Wim B van den Berg
S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis.
Arthritis and rheumatism 2010;62(11):3353-64.
2010: Bas Heinhuis; Marije I Koenders; Fons A J van de Loo; P L E M van Lent; Soo-Hyun Kim; Charles A Dinarello; Leo A B Joosten; Wim B van den Berg
IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2.
Annals of the rheumatic diseases 2010;69(10):1866-72.
2010: Peter van der Kraan; E N Blaney Davidson; Wim B van den Berg
Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(6):735-41.
2010: Nuria Maicas; M Luisa Ferrándiz; Isabel Devesa; Roberto Motterlini; Marije I Koenders; Wim B van den Berg; María José Alcaraz
The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model.
European journal of pharmacology 2010;634(1-3):184-91.
2010: Arjen B Blom; P L E M van Lent; Peter van der Kraan; Wim B van den Berg
To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy.
Current drug targets 2010;11(5):620-9.
2010: Marije I Koenders; Wim B van den Berg
Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?
Clinical and experimental immunology 2010;159(2):131-6.
2010: Myew-Ling Toh; Gaelle Gonzales; Marije I Koenders; Anne Tournadre; David Boyle; Erik Lubberts; Yuan Zhou; Gary S Firestein; Wim B van den Berg; Pierre Miossec
Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression.
PloS one 2010;5(10):e13416.
2010: Onno J Arntz; Jeroen Geurts; Sharon Veenbergen; Miranda B Bennink; Ben T van den Brand; Shahla Abdollahi-Roodsaz; Wim B van den Berg; Fons A J van de Loo
A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis.
Arthritis research & therapy 2010;12(2):R61.
2010: Theo S Plantinga; Jaap Fransen; Nozomi Takahashi; Rinke Stienstra; Piet L van Riel; Wim B van den Berg; Mihai G Netea; Leo A B Joosten
Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis.
Arthritis research & therapy 2010;12(1):R26.
2010: Peter van der Kraan; Esmeralda N Blaney Davidson; Wim B van den Berg
A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis.
Arthritis research & therapy 2010;12(1):201.
2010: Sharon Veenbergen; Ruben L Smeets; Miranda B Bennink; Onno J Arntz; Leo A B Joosten; Wim B van den Berg; Fons A J van de Loo
The natural soluble form of IL-18 receptor beta exacerbates collagen-induced arthritis via modulation of T-cell immune responses.
Annals of the rheumatic diseases 2010;69(1):276-83.
2009: Leo A B Joosten; Mihai G Netea; Giamila Fantuzzi; Marije I Koenders; Monique M A Helsen; Helmut Sparrer; Christine T Pham; Jos W M van der Meer; Charles A Dinarello; Wim B van den Berg
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Arthritis and rheumatism 2009;60(12):3651-62.
2009: Mark Wenink; Kim C M Santegoets; Jacobus C A Broen; Lenny van Bon; Shahla Abdollahi-Roodsaz; Calin Popa; Richard Huijbens; Thijs Remijn; Erik Lubberts; Piet L C M van Riel; Wim B van den Berg; Timothy R D J Radstake
TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):6960-70.
2009: Peter van der Kraan; E N Blaney Davidson; A Blom; Wim B van den Berg
TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(12):1539-45.
2009: Shahla Abdollahi-Roodsaz; Leo A B Joosten; Marije I Koenders; Ben T van den Brand; Fons A J van de Loo; Wim B van den Berg
Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation.
The American journal of pathology 2009;175(5):2004-13.
2009: Jeroen Geurts; Leo A B Joosten; Nozomi Takahashi; Onno J Arntz; Anton Glück; Miranda B Bennink; Wim B van den Berg; Fons A J van de Loo
Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1877-87.
2009: Wim B van den Berg; Pierre Miossec
IL-17 as a future therapeutic target for rheumatoid arthritis.
Nature reviews. Rheumatology 2009;5(10):549-53.
2009: P L E M van Lent; W Hofkens; Arjen B Blom; L Grevers; Annet Sloetjes; N Takahashi; L J van Tits; T Vogl; Johannes Roth; M P de Winther; Wim B van den Berg
Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis.
Arthritis and rheumatism 2009;60(10):2954-65.
2009: Mark Wenink; Kim C M Santegoets; Mieke F Roelofs; Richard Huijbens; Hans J P M Koenen; Ronald van Beek; Irma Joosten; Friederike Meyer-Wentrup; Linda Mathsson; Johan Ronnelid; Gosse J Adema; Ezio Bonvini; Scott Koenig; Wim B van den Berg; Piet L C M van Riel; Timothy R D J Radstake
The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4509-20.
2009: Mieke F Roelofs; Mark Wenink; F Brentano; Shahla Abdollahi-Roodsaz; Birgitte Oppers-Walgreen; Pilar Barrera; P L C M van Riel; Leo A B Joosten; D Kyburz; Wim B van den Berg; T R D J Radstake
Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA).
Annals of the rheumatic diseases 2009;68(9):1486-93.
2009: Esmeralda N Blaney Davidson; Dennis F G Remst; Elly L Vitters; Henk M van Beuningen; Arjen B Blom; Marie-Jose Goumans; Wim B van den Berg; Peter van der Kraan
Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7937-45.
2009: Frank van de Veerdonk; Renoud J Marijnissen; Bart Jan Kullberg; Hans J P M Koenen; Shih-Chin James Cheng; Irma Joosten; Wim B van den Berg; David L Williams; Jos W M van der Meer; Leo A B Joosten; Mihai G Netea
The macrophage mannose receptor induces IL-17 in response to Candida albicans.
Cell host & microbe 2009;5(4):329-40.
2009: Lilyanne C Grevers; P L E M van Lent; Marije I Koenders; Birgitte Walgreen; Annet Sloetjes; Falk Nimmerjahn; J Sjef Verbeek; Wim B van den Berg
Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis.
Arthritis and rheumatism 2009;60(2):396-407.
2009: Arjen B Blom; Sarah M Brockbank; P L E M van Lent; Henk M van Beuningen; Jeroen Geurts; Nozomi Takahashi; Peter van der Kraan; Fons A J van de Loo; B Willem Schreurs; Kristen Clements; Peter Newham; Wim B van den Berg
Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.
Arthritis and rheumatism 2009;60(2):501-12.
2009: Fons A J van de Loo; Wim B van den Berg
Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis?
Arthritis research & therapy 2009;11(6):132.
2009: P L E M van Lent; Gerard C Krijger; Wouter Hofkens; Victor A Nievaart; Annet Sloetjes; Ray L Moss; Gerben A Koning; Wim B van den Berg
Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy.
International journal of radiation biology 2009;85(10):860-71.
2008: P L E M van Lent; L C Grevers; Arjen B Blom; Onno J Arntz; Fons A J van de Loo; Peter van der Kraan; Shahla Abdollahi-Roodsaz; G Srikrishna; H Freeze; Annet Sloetjes; W Nacken; T Vogl; Johannes Roth; Wim B van den Berg
Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis.
Arthritis and rheumatism 2008;58(12):3776-87.
2008: Shahla Abdollahi-Roodsaz; Leo A B Joosten; Monique M A Helsen; Birgitte Walgreen; P L E M van Lent; Liduine Van Den Bersselaar; Marije I Koenders; Wim B van den Berg
Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production.
Arthritis and rheumatism 2008;58(12):3753-64.
2008: Sharon Veenbergen; Miranda B Bennink; Alfons S K de Hooge; Onno J Arntz; Ruben L Smeets; Wim B van den Berg; Fons A J van de Loo
Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis.
Arthritis and rheumatism 2008;58(12):3742-52.
2008: P L E M van Lent; L Grevers; Arjen B Blom; Annet Sloetjes; J S Mort; T Vogl; W Nacken; Wim B van den Berg; Johannes Roth
Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis.
Annals of the rheumatic diseases 2008;67(12):1750-8.
2008: Marije I Koenders; Isabel Devesa; Renoud J Marijnissen; Shahla Abdollahi-Roodsaz; Mieke Boots; Birgitte Walgreen; Franco E Di Padova; Martin J H Nicklin; Leo A B Joosten; Wim B van den Berg
Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.
Arthritis and rheumatism 2008;58(11):3461-70.
2008: Nozomi Takahashi; Victor C L de Jager; Anton Glück; Martin Letzkus; Nicole Hartmann; Staedtler Frank; Fátima Ribeiro-Dias; Marleen Heuvelmans-Jacobs; Wim B van den Berg; Leo A B Joosten
The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40.
Arthritis and rheumatism 2008;58(11):3471-84.
2008: Nozomi Takahashi; Jeroen W J van Kilsdonk; Benedikt Ostendorf; Roel Smeets; Sophia W M Bruggeman; Angel Alonso; Fons van de Loo; Matthias Schneider; Wim B van den Berg; Guido W M Swart
Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB.
Biochemical and biophysical research communications 2008;374(3):424-30.
2008: M Luisa Ferrándiz; N Maicas; I Garcia-Arnandis; María Carmen Terencio; Roberto Motterlini; Isabel Devesa; Leo A B Joosten; Wim B van den Berg; María José Alcaraz
Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis.
Annals of the rheumatic diseases 2008;67(9):1211-7.
2008: Nozomi Takahashi; Ineke Vanlaere; Riet De Rycke; Anje Cauwels; Leo A B Joosten; Erik Lubberts; Wim B van den Berg; Claude Libert
IL-17 produced by Paneth cells drives TNF-induced shock.
The Journal of experimental medicine 2008;205(8):1755-61.
2008: Leo A B Joosten; Bas Heinhuis; Shahla Abdollahi-Roodsaz; Gerben Ferwerda; Lionel Lebourhis; Dana J Philpott; Marie-Anne Nahori; Calin Popa; Servaas A Morre; Jos W M van der Meer; Stephen E Girardin; Mihai G Netea; Wim B van den Berg
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9017-22.
2008: Mieke F Roelofs; Mark Wenink; Erik J M Toonen; Marieke Coenen; Leo A B Joosten; Wim B van den Berg; P L C M van Riel; Timothy Radstake
The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis.
The Journal of rheumatology 2008;35(4):558-61.
2008: Peter I Boross; P L E M van Lent; Javier Martin-Ramirez; Jos van der Kaa; Melissa H C M Mulder; Jill W C Claassens; Wim B van den Berg; Victoria L Arandhara; Sjef Verbeek
Destructive arthritis in the absence of both FcgammaRI and FcgammaRIII.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5083-91.
2008: Peter van der Kraan; Wim B van den Berg
Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing.
Ageing research reviews 2008;7(2):106-13.
2008: Mieke F Roelofs; Shahla Abdollahi-Roodsaz; Leo A B Joosten; Wim B van den Berg; Timothy Radstake
The orchestra of Toll-like receptors and their potential role in frequently occurring rheumatic conditions.
Arthritis and rheumatism 2008;58(2):338-48.
2008: Leo A B Joosten; Monique M A Helsen; Fons A J van de Loo; Wim B van den Berg
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra.
Arthritis and rheumatism 2008;58(2 Suppl):S110-22.
2008: Wim B van den Berg
Cytokines and joint erosion in arthritis.
Nature clinical practice. Rheumatology 2008;4(2):58-9.
2008: RIEKE ALTEN; Hermann Gram; Leo A Joosten; Wim B van den Berg; Joachim Sieper; Siegfrid Wassenberg; Gerd Burmester; Piet van Riel; Maria Diaz-Lorente; Gerardus J M Bruin; Thasia G Woodworth; Christiane Rordorf; Yannik Batard; Andrew M Wright; Thomas Jung
The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis.
Arthritis research & therapy 2008;10(3):R67.
2008: Wim B van den Berg
Lessons from animal models of osteoarthritis.
Current rheumatology reports 2008;10(1):26-9.
2008: Leo A B Joosten; Shahla Abdollahi-Roodsaz; Marleen Heuvelmans-Jacobs; Monique M A Helsen; Liduine Van Den Bersselaar; Birgitte Oppers-Walgreen; Marije I Koenders; Wim B van den Berg
T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17.
Arthritis and rheumatism 2008;58(1):98-108.
2008: Shahla Abdollahi-Roodsaz; Leo A B Joosten; Marije I Koenders; Isabel Devesa; Mieke F Roelofs; Timothy Radstake; Marleen Heuvelmans-Jacobs; Shizuo Akira; Martin J H Nicklin; Fátima Ribeiro-Dias; Wim B van den Berg
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.
The Journal of clinical investigation 2008;118(1):205-16.
2007: E N Blaney Davidson; Elly L Vitters; Henk M van Beuningen; Fons A J van de Loo; Wim B van den Berg; Peter van der Kraan
Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation.
Arthritis and rheumatism 2007;56(12):4065-73.
2007: J Geurts; Onno J Arntz; Miranda B Bennink; Leo A B Joosten; Wim B van den Berg; Fons A J van de Loo
Application of a disease-regulated promoter is a safer mode of local IL-4 gene therapy for arthritis.
Gene therapy 2007;14(23):1632-8.
2007: Wim B van den Berg; P L E M van Lent; Leo A B Joosten; Shahla Abdollahi-Roodsaz; Marije I Koenders
Amplifying elements of arthritis and joint destruction.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii45-8.
2007: Calin Popa; Shahla Abdollahi-Roodsaz; Leo A B Joosten; Nozomi Takahashi; Tom Sprong; Giovanni Matera; Maria Carla Liberto; Alfredo Foca; Marcel van Deuren; Bart Jan Kullberg; Wim B van den Berg; Jos W M van der Meer; Mihai G Netea
Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4.
Infection and immunity 2007;75(10):4831-7.
2007: Shahla Abdollahi-Roodsaz; Leo A B Joosten; Mieke F Roelofs; Timothy Radstake; Giovanni Matera; Calin Popa; Jos W M van der Meer; Mihai G Netea; Wim B van den Berg
Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis.
Arthritis and rheumatism 2007;56(9):2957-67.
2007: Esmeralda N Blaney Davidson; Peter van der Kraan; Wim B van den Berg
TGF-beta and osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(6):597-604.
2007: Christine Plater-Zyberk; Leo A B Joosten; Monique M A Helsen; julia hepp; Patrick A Baeuerle; Wim B van den Berg
GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice.
Annals of the rheumatic diseases 2007;66(4):452-7.
2007: Peter van der Kraan; Wim B van den Berg
Osteophytes: relevance and biology.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(3):237-44.
2007: P L E M van Lent; Arjen B Blom; L Grevers; Annet Sloetjes; Wim B van den Berg
Toll-like receptor 4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis: Toll-like receptor 4 largely regulates FcgammaR expression by interleukin 10.
Annals of the rheumatic diseases 2007;66(3):334-40.
2007: Arjen B Blom; Peter van der Kraan; Wim B van den Berg
Cytokine targeting in osteoarthritis.
Current drug targets 2007;8(2):283-92.
2007: Wim B van den Berg; Leo A B Joosten; P L E M van Lent
Murine antigen-induced arthritis.
Methods in molecular medicine 2007;136():243-53.
2007: Esmeralda N Blaney Davidson; Elly L Vitters; P L E M van Lent; Fons A J van de Loo; Wim B van den Berg; Peter van der Kraan
Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling.
Arthritis research & therapy 2007;9(5):R102.
2007: Arjen B Blom; P L E M van Lent; Sten Libregts; A E M Holthuysen; Peter van der Kraan; Nico van Rooijen; Wim B van den Berg
Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3.
Arthritis and rheumatism 2007;56(1):147-57.
2006: P L E M van Lent; Lilyanne Grevers; Erik Lubberts; Teun J de Vries; K C A M Nabbe; Sjef Verbeek; Birgit Oppers; Annet Sloetjes; Arjen B Blom; Wim B van den Berg
Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation.
Arthritis and rheumatism 2006;54(12):3868-77.
2006: Timothy Radstake; Barbara Franke; Mark Wenink; K C A M Nabbe; Marieke Coenen; Paco M J Welsing; Ezio Bonvini; Scott Koenig; Wim B van den Berg; Pilar Barrera; P L C M van Riel
The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis.
Arthritis and rheumatism 2006;54(12):3828-37.
2006: P L E M van Lent; Annet Sloetjes; A Blom; G Krijger; G Koning; S Nievaart; Wim B van den Berg; R Moss
Selective elimination of synovial macrophages by boron neutron capture therapy prevents onset of murine experimental arthritis.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e106-7.
2006: Marije I Koenders; Leo A B Joosten; Wim B van den Berg
Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis.
Annals of the rheumatic diseases 2006;65 Suppl 3():iii29-33.
2006: Esmeralda N Blaney Davidson; Elly L Vitters; Peter van der Kraan; Wim B van den Berg
Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation.
Annals of the rheumatic diseases 2006;65(11):1414-21.
2006: Fons A J van de Loo; Jeroen Geurts; Wim B van den Berg
Gene therapy works in animal models of rheumatoid arthritis...so what!
Current rheumatology reports 2006;8(5):386-93.
2006: Mihai G Netea; Leo A B Joosten; Eli Lewis; Dalan R Jensen; Peter J Voshol; Bart Jan Kullberg; Cees J Tack; Han van Krieken; Soo-Hyun Kim; Anton F H Stalenhoef; Fons A J van de Loo; Ineke Verschueren; Leslie Pulawa; Shizuo Akira; Robert H Eckel; Charles A Dinarello; Wim B van den Berg; Jos W M van der Meer
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Nature medicine 2006;12(6):650-6.
2006: Mieke F Roelofs; Wilbert C Boelens; Leo A B Joosten; Shahla Abdollahi-Roodsaz; Jeroen Geurts; Lisa Wunderink; B Willem Schreurs; Wim B van den Berg; Timothy Radstake
Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7021-7.
2006: Marije I Koenders; Erik Lubberts; Fons A J van de Loo; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Jay K Kolls; Franco E Di Padova; Leo A B Joosten; Wim B van den Berg
Interleukin-17 acts independently of TNF-alpha under arthritic conditions.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6262-9.
2006: Ruben L Smeets; Sharon Veenbergen; Onno J Arntz; Miranda B Bennink; Leo A B Joosten; Wim B van den Berg; Fons A J van de Loo
A novel role for suppressor of cytokine signaling 3 in cartilage destruction via induction of chondrocyte desensitization toward insulin-like growth factor.
Arthritis and rheumatism 2006;54(5):1518-28.
2006: Mark Wenink; Wim B van den Berg; P L C M van Riel; Timothy Radstake
Fc gamma receptor mediated modulation of dendritic cells as a potential strategy in the battle against rheumatoid arthritis.
The Netherlands journal of medicine 2006;64(4):103-8.
2006: Leo A B Joosten; Mihai G Netea; Soo-Hyun Kim; Do-Young Yoon; Birgitte Oppers-Walgreen; Timothy Radstake; Pilar Barrera; Fons A J van de Loo; Charles A Dinarello; Wim B van den Berg
IL-32, a proinflammatory cytokine in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3298-303.
2006: Esmeralda N Blaney Davidson; Elly L Vitters; Wim B van den Berg; Peter van der Kraan
TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7.
Arthritis research & therapy 2006;8(3):R65.
2005: Myew-Ling Toh; Saw See Hong; Fons A J van de Loo; Laure Franqueville; Leif Lindholm; Wim B van den Berg; Pierre Boulanger; Pierre Miossec
Enhancement of adenovirus-mediated gene delivery to rheumatoid arthritis synoviocytes and synovium by fiber modifications: role of arginine-glycine-aspartic acid (RGD)- and non-RGD-binding integrins.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7687-98.
2005: Timothy Radstake; K C A M Nabbe; Mark Wenink; Mieke F Roelofs; A Oosterlaar; Antoine W T van Lieshout; Pilar Barrera; P L E M van Lent; Wim B van den Berg
Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc gamma RII expression, which has clear functional consequences.
Annals of the rheumatic diseases 2005;64(12):1737-43.
2005: Timothy Radstake; Antoine W T van Lieshout; P L C M van Riel; Wim B van den Berg; Gosse J Adema
Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(11):1532-8.
2005: Marije I Koenders; Jay K Kolls; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Leo A B Joosten; Jill R Schurr; Paul Schwarzenberger; Wim B van den Berg; Erik Lubberts
Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.
Arthritis and rheumatism 2005;52(10):3239-47.
2005: Erik Lubberts; Paul Schwarzenberger; Weitao Huang; Jill R Schurr; Jacques J Peschon; Wim B van den Berg; Jay K Kolls
Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3360-8.
2005: Mieke F Roelofs; Leo A B Joosten; Shahla Abdollahi-Roodsaz; Antoine W T van Lieshout; Tom Sprong; F H J van den Hoogen; Wim B van den Berg; Timothy Radstake
The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells.
Arthritis and rheumatism 2005;52(8):2313-22.
2005: Ruben L Smeets; Leo A B Joosten; Onno J Arntz; Miranda B Bennink; N Takahashi; H Carlsen; M U Martin; Wim B van den Berg; Fons A J van de Loo
Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist.
Arthritis and rheumatism 2005;52(7):2202-11.
2005: Marije I Koenders; Erik Lubberts; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Franco E Di Padova; Mieke Boots; Hermann Gram; Leo A B Joosten; Wim B van den Berg
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.
The American journal of pathology 2005;167(1):141-9.
2005: N Takahashi; K Rieneck; Peter van der Kraan; Henk M van Beuningen; Elly L Vitters; Klaus Bendtzen; Wim B van den Berg
Elucidation of IL-1/TGF-beta interactions in mouse chondrocyte cell line by genome-wide gene expression.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(5):426-38.
2005: Robbert van der Voort; Antoine W T van Lieshout; Liza W J Toonen; Annet W Slöetjes; Wim B van den Berg; Carl G Figdor; Timothy Radstake; Gosse J Adema
Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints.
Arthritis and rheumatism 2005;52(5):1381-91.
2005: K C A M Nabbe; Peter I Boross; A E M Holthuysen; A W Sloëtjes; Jay K Kolls; Sjef Verbeek; P L E M van Lent; Wim B van den Berg
Joint inflammation and chondrocyte death become independent of Fcgamma receptor type III by local overexpression of interferon-gamma during immune complex-mediated arthritis.
Arthritis and rheumatism 2005;52(3):967-74.
2005: Marije I Koenders; Erik Lubberts; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Jay K Kolls; Leo A B Joosten; Wim B van den Berg
Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1.
Arthritis and rheumatism 2005;52(3):975-83.
2005: P L E M van Lent; Paul Span; Annet Sloetjes; Timothy Radstake; Antoine W T van Lieshout; Joop J T M Heuvel; C G J Sweep; Wim B van den Berg
Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(3):368-74.
2005: Timothy Radstake; Robbert van der Voort; M ten Brummelhuis; Maarten C de Waal Malefijt; Maaike W G Looman; Carl G Figdor; Wim B van den Berg; Pilar Barrera; Gosse J Adema
Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors.
Annals of the rheumatic diseases 2005;64(3):359-67.
2005: Antoine W T van Lieshout; Pilar Barrera; R L Smeets; Gerard J Pesman; P L C M van Riel; Wim B van den Berg; Timothy Radstake
Inhibition of TNF alpha during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF alpha blockade in rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(3):408-14.
2005: Esmeralda N Blaney Davidson; Alwin Scharstuhl; Elly L Vitters; Peter van der Kraan; Wim B van den Berg
Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity.
Arthritis research & therapy 2005;7(6):R1338-47.
2005: P L E M van Lent; K C A M Nabbe; Arjen B Blom; Annet Sloetjes; A E M Holthuysen; Jay K Kolls; Fons A J van de Loo; Steven M Holland; Wim B van den Berg
NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis.
Arthritis research & therapy 2005;7(4):R885-95.
2005: K C A M Nabbe; P L E M van Lent; A E M Holthuysen; Annet W Sloëtjes; Alisa E Koch; Timothy Radstake; Wim B van den Berg
Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation.
Arthritis research & therapy 2005;7(2):R392-401.
2005: Wim B van den Berg
Animal models of arthritis. What have we learned?
The Journal of rheumatology. Supplement 2005;72():7-9.
2005: Erik Lubberts; Marije I Koenders; Wim B van den Berg
The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.
Arthritis research & therapy 2005;7(1):29-37.
2005: Alfons S K de Hooge; Fons A J van de Loo; Miranda B Bennink; Onno J Arntz; Pieter de Hooge; Wim B van den Berg
Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(1):66-73.
2004: Timothy Radstake; Mieke F Roelofs; Yvonne Bastiaansen-Jenniskens; Birgitte Oppers-Walgreen; P L C M van Riel; Pilar Barrera; Leo A B Joosten; Wim B van den Berg
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.
Arthritis and rheumatism 2004;50(12):3856-65.
2004: Timothy Radstake; Arjen B Blom; Annet W Slöetjes; E O F van Gorselen; Gerard J Pesman; Linda P H Engelen; Ruurd Torensma; Wim B van den Berg; Carl G Figdor; P L E M van Lent; Gosse J Adema; Pilar Barrera
Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(12):1556-63.
2004: Leo A B Joosten; Ruben L Smeets; Marije I Koenders; Liduine Van Den Bersselaar; Monique M A Helsen; Birgitte Oppers-Walgreen; Erik Lubberts; Yoichiro Iwakura; Fons A J van de Loo; Wim B van den Berg
Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction.
The American journal of pathology 2004;165(3):959-67.
2004: Arjen B Blom; P L E M van Lent; A E M Holthuysen; Peter van der Kraan; Johannes Roth; Nico van Rooijen; Wim B van den Berg
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(8):627-35.
2004: Alfons S K de Hooge; Fons A J van de Loo; Marije I Koenders; Miranda B Bennink; Onno J Arntz; Thomas Kolbe; Wim B van den Berg
Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice.
Arthritis and rheumatism 2004;50(6):2014-23.
2004: Timothy Radstake; P L E M van Lent; Gerard J Pesman; Arjen B Blom; Fred G J Sweep; J Rönnelid; Gosse J Adema; Pilar Barrera; Wim B van den Berg
High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering.
Annals of the rheumatic diseases 2004;63(6):696-702.
2004: Josbert M Metselaar; Wim B van den Berg; A E M Holthuysen; Marca H M Wauben; Gert Storm; P L E M van Lent
Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis.
Annals of the rheumatic diseases 2004;63(4):348-53.
2004: Fons A J van de Loo; Alfons S K de Hooge; Ruben L Smeets; Andrew C Bakker; Miranda B Bennink; Onno J Arntz; Leo A B Joosten; Henk M van Beuningen; P K van der Kraan; Alan W Varley; Wim B van den Berg
An inflammation-inducible adenoviral expression system for local treatment of the arthritic joint.
Gene therapy 2004;11(7):581-90.
2004: Peter van der Kraan; Fons A J van de Loo; Wim B van den Berg
Role of gene therapy in tissue engineering procedures in rheumatology: the use of animal models.
Biomaterials 2004;25(9):1497-504.
2004: Timothy Radstake; Barbara Franke; Suzanne Hanssen; Mihai G Netea; Paco M J Welsing; Pilar Barrera; Leo A B Joosten; P L C M van Riel; Wim B van den Berg
The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.
Arthritis and rheumatism 2004;50(3):999-1001.
2004: Erik Lubberts; Marije I Koenders; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Christina J J Coenen-de Roo; Leo A B Joosten; Wim B van den Berg
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion.
Arthritis and rheumatism 2004;50(2):650-9.
2004: Fons A J van de Loo; Ruben L Smeets; Wim B van den Berg
Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?
Arthritis research & therapy 2004;6(5):183-96.
2004: P L E M van Lent; Arjen B Blom; Peter van der Kraan; A E M Holthuysen; Elly L Vitters; Nico van Rooijen; Ruben L Smeets; K C A M Nabbe; Wim B van den Berg
Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation.
Arthritis and rheumatism 2004;50(1):103-11.
2003: Alwin Scharstuhl; Elly L Vitters; Peter van der Kraan; Wim B van den Berg
Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis.
Arthritis and rheumatism 2003;48(12):3442-51.
2003: Mihai G Netea; Alieke G Vonk; Mabel van den Hoven; Ineke Verschueren; Leo A B Joosten; J H J M van Krieken; Wim B van den Berg; Jos W M van der Meer; Bart Jan Kullberg
Differential role of IL-18 and IL-12 in the host defense against disseminated Candida albicans infection.
European journal of immunology 2003;33(12):3409-17.
2003: Leo A B Joosten; Marije I Koenders; Ruben L Smeets; Marleen Heuvelmans-Jacobs; Monique M A Helsen; Kiyoshi Takeda; Shizuo Akira; Erik Lubberts; Fons A J van de Loo; Wim B van den Berg
Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6145-53.
2003: Alwin Scharstuhl; Robin J W Diepens; Joost Lensen; Elly L Vitters; Henk M van Beuningen; Peter van der Kraan; Wim B van den Berg
Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(11):773-82.
2003: P L E M van Lent; K C A M Nabbe; Peter I Boross; Arjen B Blom; Johannes Roth; A E M Holthuysen; Annet Sloetjes; Sjef Verbeek; Wim B van den Berg
The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes.
The American journal of pathology 2003;163(5):1839-48.
2003: Ruben L Smeets; Fons A J van de Loo; Leo A B Joosten; Onno J Arntz; Miranda B Bennink; WA Loesberg; I P Dmitriev; D T Curiel; M U Martin; Wim B van den Berg
Effectiveness of the soluble form of the interleukin-1 receptor accessory protein as an inhibitor of interleukin-1 in collagen-induced arthritis.
Arthritis and rheumatism 2003;48(10):2949-58.
2003: Fons A J van de Loo; Miranda B Bennink; Onno J Arntz; Ruben L Smeets; Erik Lubberts; Leo A B Joosten; P L E M van Lent; Christina J J Coenen-de Roo; Salvatore Cuzzocrea; Brahm H Segal; Steven M Holland; Wim B van den Berg
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
The American journal of pathology 2003;163(4):1525-37.
2003: Erik R Vossenaar; Suzanne Nijenhuis; Monique M A Helsen; Annemarie van der Heijden; Tatsuo Senshu; Wim B van den Berg; Walther J van Venrooij; Leo A B Joosten
Citrullination of synovial proteins in murine models of rheumatoid arthritis.
Arthritis and rheumatism 2003;48(9):2489-500.
2003: K C A M Nabbe; P L E M van Lent; A E M Holthuysen; Jay K Kolls; Sjef Verbeek; Wim B van den Berg
FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis.
The American journal of pathology 2003;163(2):743-52.
2003: Pieter Buma; Jeroen S Pieper; Tony G van Tienen; Job L C van Susante; Peter van der Kraan; Jacques H Veerkamp; Wim B van den Berg; R P H Veth; Toin H van Kuppevelt
Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects--a study in rabbits.
Biomaterials 2003;24(19):3255-63.
2003: Alfons S K de Hooge; Fons A J van de Loo; Miranda B Bennink; Onno J Arntz; Theo J W Fiselier; Marcel J A M Franssen; Leo A B Joosten; P L E M van Lent; Carl D Richards; Wim B van den Berg
Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient mice.
Arthritis and rheumatism 2003;48(6):1750-61.
2003: Ruben L Smeets; Fons A J van de Loo; Onno J Arntz; Miranda B Bennink; Leo A B Joosten; Wim B van den Berg
Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice.
Gene therapy 2003;10(12):1004-11.
2003: Arjen B Blom; P L E M van Lent; A E M Holthuysen; C Jacobs; Wim B van den Berg
Skewed balance in basal expression and regulation of activating v inhibitory Fcgamma receptors in macrophages of collagen induced arthritis sensitive mice.
Annals of the rheumatic diseases 2003;62(5):465-71.
2003: Arjen B Blom; Timothy Radstake; A E M Holthuysen; Annet W Slöetjes; Gerard J Pesman; Fred G J Sweep; Fons A J van de Loo; Leo A B Joosten; Pilar Barrera; P L E M van Lent; Wim B van den Berg
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
Arthritis and rheumatism 2003;48(4):1002-14.
2003: Alwin Scharstuhl; Harrie L Glansbeek; Elly L Vitters; Peter van der Kraan; Wim B van den Berg
Large scale protein production of the extracellular domain of the transforming growth factor-beta type II receptor using the Pichia pastoris expression system.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;786(1-2):271-7.
2003: Erik Lubberts; Liduine Van Den Bersselaar; Birgitte Oppers-Walgreen; Paul Schwarzenberger; Christina J J Coenen-de Roo; Jay K Kolls; Leo A B Joosten; Wim B van den Berg
IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2655-62.
2003: P L E M van Lent; Carl G Figdor; Pilar Barrera; Karin van Ginkel; Annet W Slöetjes; Wim B van den Berg; Ruurd Torensma
Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells.
Arthritis and rheumatism 2003;48(2):360-9.
2003: Leo A B Joosten; Timothy Radstake; Erik Lubberts; Liduine Van Den Bersselaar; P L C M van Riel; P L E M van Lent; Pilar Barrera; Wim B van den Berg
Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis.
Arthritis and rheumatism 2003;48(2):339-47.
2003: Erik Lubberts; Wim B van den Berg
Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritis.
Advances in experimental medicine and biology 2003;520():194-202.
2003: K C A M Nabbe; Arjen B Blom; A E M Holthuysen; Peter I Boross; Johannes Roth; Sjef Verbeek; P L E M van Lent; Wim B van den Berg
Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis.
Arthritis and rheumatism 2003;48(1):255-65.
2002: Henk M van Beuningen; reinout stoop; Pieter Buma; N Takahashi; Peter van der Kraan; Wim B van den Berg
Phenotypic differences in murine chondrocyte cell lines derived from mature articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(12):977-86.
2002: Alwin Scharstuhl; Henk M van Beuningen; Elly L Vitters; Peter van der Kraan; Wim B van den Berg
Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice.
Annals of the rheumatic diseases 2002;61(12):1095-8.
2002: Erik Lubberts; Birgitte Oppers-Walgreen; Allison R Pettit; Liduine Van Den Bersselaar; Leo A B Joosten; Steven R Goldring; Ellen M Gravallese; Wim B van den Berg
Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis.
Arthritis and rheumatism 2002;46(11):3055-64.
2002: Peter van der Kraan; Pieter Buma; T van Kuppevelt; Wim B van den Berg
Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(8):631-7.
2002: Jeroen S Pieper; Peter van der Kraan; Theo Hafmans; J Kamp; Pieter Buma; Job L C van Susante; Wim B van den Berg; Jacques H Veerkamp; Toin H van Kuppevelt
Crosslinked type II collagen matrices: preparation, characterization, and potential for cartilage engineering.
Biomaterials 2002;23(15):3183-92.
2002: Alwin Scharstuhl; Harrie L Glansbeek; Henk M van Beuningen; Elly L Vitters; Peter van der Kraan; Wim B van den Berg
Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):507-14.
2002: Andrew C Bakker; Fons A J van de Loo; Leo A B Joosten; Onno J Arntz; Alan W Varley; Robert S Munford; Wim B van den Berg
C3-Tat/HIV-regulated intraarticular human interleukin-1 receptor antagonist gene therapy results in efficient inhibition of collagen-induced arthritis superior to cytomegalovirus-regulated expression of the same transgene.
Arthritis and rheumatism 2002;46(6):1661-70.
2002: Leo A B Joosten; Marleen Heuvelmans-Jacobs; Erik Lubberts; Fons A J van de Loo; Andrew C Bakker; Monique M A Helsen; Carl D Richards; Wim B van den Berg
Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis.
Arthritis and rheumatism 2002;46(5):1379-89.
2002: P L E M van Lent; A E M Holthuysen; Annet W Slöetjes; Erik Lubberts; Wim B van den Berg
Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(3):234-43.
2002: Fons A J van de Loo; Wim B van den Berg
Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators.
Rheumatic diseases clinics of North America 2002;28(1):127-49.
2001: Andrew C Bakker; Fons A J van de Loo; Leo A B Joosten; Miranda B Bennink; Onno J Arntz; I P Dmitriev; E A Kashentsera; D T Curiel; Wim B van den Berg
A tropism-modified adenoviral vector increased the effectiveness of gene therapy for arthritis.
Gene therapy 2001;8(23):1785-93.
2001: Christine Plater-Zyberk; Leo A B Joosten; Monique M A Helsen; P Sattonnet-Roche; C Siegfried; Sami Alouani; Fons A J van de Loo; Pierre Graber; S Aloni; Rocco Cirillo; Erik Lubberts; Charles A Dinarello; Wim B van den Berg; Yolande Chvatchko
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis.
The Journal of clinical investigation 2001;108(12):1825-32.
2001: P L E M van Lent; K C A M Nabbe; Arjen B Blom; A E M Holthuysen; Annet Sloetjes; L B A Van De Putte; Sjef Verbeek; Wim B van den Berg
Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis.
The American journal of pathology 2001;159(6):2309-20.
2001: P L E M van Lent; R Licht; H Dijkman; A E M Holthuysen; J H Berden; Wim B van den Berg
Uptake of apoptotic leukocytes by synovial lining macrophages inhibits immune complex-mediated arthritis.
Journal of leukocyte biology 2001;70(5):708-14.
2001: Wim B van den Berg; Peter van der Kraan; Alwin Scharstuhl; Henk M van Beuningen
Growth factors and cartilage repair.
Clinical orthopaedics and related research 2001;(391 Suppl):S244-50.
2001: Wim B van den Berg
Lessons from animal models of osteoarthritis.
Current opinion in rheumatology 2001;13(5):452-6.
2001: Mihai G Netea; Bart Jan Kullberg; Leo A B Joosten; Tom Sprong; Ineke Verschueren; Otto Boerman; F Amiot; Wim B van den Berg; Jos W M van der Meer
Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways.
European journal of immunology 2001;31(9):2529-38.
2001: Jeroen S Pieper; Pieter Buma; Toin H van Kuppevelt; Henk M van Beuningen; Peter van der Kraan; J H Veerkamp; Wim B van den Berg
Linkage of chondroitin-sulfate to type I collagen scaffolds stimulates the bioactivity of seeded chondrocytes in vitro.
Biomaterials 2001;22(17):2359-69.
2001: Erik Lubberts; Leo A B Joosten; Birgit Oppers; Liduine Van Den Bersselaar; Christina J J Coenen-de Roo; Jay K Kolls; Paul Schwarzenberger; Fons A J van de Loo; Wim B van den Berg
IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):1004-13.
2001: Pilar Barrera; Leo A B Joosten; Alfons A den Broeder; L B A Van De Putte; P L C M van Riel; Wim B van den Berg
Effects of treatment with a fully human anti-tumour necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFalpha in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2001;60(7):660-9.
2001: reinout stoop; Pieter Buma; Peter van der Kraan; A P Hollander; R C Billinghurst; Tineke Meijers; A Robin Poole; Wim B van den Berg
Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(4):308-15.
2001: Andrew C Bakker; Fons A J van de Loo; Henk M van Beuningen; P Sime; P L E M van Lent; Peter van der Kraan; C D Richards; Wim B van den Berg
Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):128-36.
2001: Peter van der Kraan; reinout stoop; Tineke Meijers; A Robin Poole; Wim B van den Berg
Expression of type X collagen in young and old C57Bl/6 and Balb/c mice. Relation with articular cartilage degeneration.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):92-100.
2001: M Chabaud; Erik Lubberts; Leo A B Joosten; Wim B van den Berg; Pierre Miossec
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis.
Arthritis research 2001;3(3):168-77.
2001: Wim B van den Berg
Anti-cytokine therapy in chronic destructive arthritis.
Arthritis research 2001;3(1):18-26.
2000: Alfons S K de Hooge; Fons A J van de Loo; Onno J Arntz; Wim B van den Berg
Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis.
The American journal of pathology 2000;157(6):2081-91.
2000: Leo A B Joosten; Fons A J van de Loo; Erik Lubberts; Monique M A Helsen; Mihai G Netea; Jos W M van der Meer; Charles A Dinarello; Wim B van den Berg
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6553-8.
2000: Wim B van den Berg
Arguments for interleukin 1 as a target in chronic arthritis.
Annals of the rheumatic diseases 2000;59 Suppl 1():i81-4.
2000: Wim B van den Berg; Leo A B Joosten; Erik Lubberts; Fons A J van de Loo; P L E M van Lent
Cytokine directed targeting in chronic arthritis.
European cytokine network 2000;11(3):481-2.
2000: reinout stoop; Pieter Buma; Peter van der Kraan; A P Hollander; R Clark Billinghurst; A Robin Poole; Wim B van den Berg
Differences in type II collagen degradation between peripheral and central cartilage of rat stifle joints after cranial cruciate ligament transection.
Arthritis and rheumatism 2000;43(9):2121-31.
2000: Pilar Barrera; A Blom; P L E M van Lent; L van Bloois; J H Beijnen; N van Rooijen; Maarten C de Waal Malefijt; L B A Van De Putte; G Storm; Wim B van den Berg
Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(9):1951-9.
2000: Erik Lubberts; Leo A B Joosten; M Chabaud; Liduine Van Den Bersselaar; Birgit Oppers; Christina J J Coenen-de Roo; Carl D Richards; Pierre Miossec; Wim B van den Berg
IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion.
The Journal of clinical investigation 2000;105(12):1697-710.
2000: Erik Lubberts; Leo A B Joosten; Fons A J van de Loo; L A van den Gersselaar; Wim B van den Berg
Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4.
Arthritis and rheumatism 2000;43(6):1300-6.
2000: Erik Lubberts; Leo A B Joosten; Liduine Van Den Bersselaar; Monique M A Helsen; Andrew C Bakker; Zhou Xing; Carl D Richards; Wim B van den Berg
Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw.
Clinical and experimental immunology 2000;120(2):375-83.
2000: P L E M van Lent; A J van Vuuren; Arjen B Blom; A E M Holthuysen; L B A Van De Putte; J G van de Winkel; Wim B van den Berg
Role of Fc receptor gamma chain in inflammation and cartilage damage during experimental antigen-induced arthritis.
Arthritis and rheumatism 2000;43(4):740-52.
2000: Peter van der Kraan; Elly L Vitters; Henk M van Beuningen; Fons A J van de Loo; Wim B van den Berg
Role of nitric oxide in the inhibition of BMP-2-mediated stimulation of proteoglycan synthesis in articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(2):82-6.
2000: Leo A B Joosten; Christina J J Coenen-de Roo; Monique M A Helsen; Erik Lubberts; Mieke Boots; Wim B van den Berg; André M M Miltenburg
Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/1 mice: amelioration of clinical, histologic, and radiologic signs of type II collagen-induced arthritis.
Arthritis and rheumatism 2000;43(3):645-55.
2000: Leo A B Joosten; Monique M A Helsen; Wim B van den Berg
Blockade of endogenous interleukin 12 results in suppression of murine streptococcal cell wall arthritis by enhancement of interleukin 10 and interleukin 1Ra.
Annals of the rheumatic diseases 2000;59(3):196-205.
2000: Arjen B Blom; P L E M van Lent; H van Vuuren ; A E M Holthuysen; C Jacobs; L B A Van De Putte; J G van de Winkel ; Wim B van den Berg
Fc gamma R expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA).
Arthritis research 2000;2(6):489-503.
2000: Job L C van Susante; Pieter Buma; Henk M van Beuningen; Wim B van den Berg; R P Veth
Responsiveness of bovine chondrocytes to growth factors in medium with different serum concentrations.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(1):68-77.
2000: Henk M van Beuningen; Harrie L Glansbeek; Peter van der Kraan; Wim B van den Berg
Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(1):25-33.
1999: Arjen B Blom; P L E M van Lent; A E M Holthuysen; Wim B van den Berg
Immune complexes, but not streptococcal cell walls or zymosan, cause chronic arthritis in mouse strains susceptible for collagen type II auto-immune arthritis.
Cytokine 1999;11(12):1046-56.
1999: JB Van Meurs; P L E M van Lent; A E M Holthuysen; D Lambrou; Ellen K Bayne; Irwin I Singer; Wim B van den Berg
Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5633-9.
1999: Wim B van den Berg; Leo A B Joosten; george kollias; F A van De Loo
Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction.
Annals of the rheumatic diseases 1999;58 Suppl 1():I40-8.
1999: reinout stoop; Peter van der Kraan; Pieter Buma; A P Hollander; R C Billinghurst; A Robin Poole; Wim B van den Berg
Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice.
Arthritis and rheumatism 1999;42(11):2381-9.
1999: Leo A B Joosten; Monique M A Helsen; Tore Saxne; Fons A J van de Loo; Dick Heinegård; Wim B van den Berg
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):5049-55.
1999: Erik Lubberts; Leo A B Joosten; Liduine Van Den Bersselaar; Monique M A Helsen; Andrew C Bakker; J B van Meurs; F L Graham; Carl D Richards; Wim B van den Berg
Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4546-56.
1999: JB Van Meurs; P L E M van Lent; reinout stoop; A E M Holthuysen; Irwin I Singer; Ellen K Bayne; J Mudgett; R Poole; C Billinghurst; Peter van der Kraan; Pieter Buma; Wim B van den Berg
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity.
Arthritis and rheumatism 1999;42(10):2074-84.
1999: Wim B van den Berg; Fons A J van de Loo; Leo A B Joosten; Onno J Arntz
Animal models of arthritis in NOS2-deficient mice.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(4):413-5.
1999: reinout stoop; Peter van der Kraan; Pieter Buma; A P Hollander; A Robin Poole; Wim B van den Berg
Denaturation of type II collagen in articular cartilage in experimental murine arthritis. Evidence for collagen degradation in both reversible and irreversible cartilage damage.
The Journal of pathology 1999;188(3):329-37.
1999: Job L C van Susante; Pieter Buma; L Schuman; G N Homminga; Wim B van den Berg; R P H Veth
Resurfacing potential of heterologous chondrocytes suspended in fibrin glue in large full-thickness defects of femoral articular cartilage: an experimental study in the goat.
Biomaterials 1999;20(13):1167-75.
1999: JB Van Meurs; P L E M van Lent; A E M Holthuysen; Irwin I Singer; Ellen K Bayne; Wim B van den Berg
Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.
Arthritis and rheumatism 1999;42(6):1128-39.
1999: JB Van Meurs; P L E M van Lent; A A van de Loo; A E M Holthuysen; Ellen K Bayne; Irwin I Singer; Wim B van den Berg
Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis.
Annals of the rheumatic diseases 1999;58(6):350-6.
1999: Leo A B Joosten; Erik Lubberts; Monique M A Helsen; Tore Saxne; Christina J J Coenen-de Roo; D Heinegård; Wim B van den Berg
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis.
Arthritis research 1999;1(1):81-91.
1999: Leo A B Joosten; Monique M A Helsen; Tore Saxne; D Heinegård; L B A Van De Putte; Wim B van den Berg
Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(1):48-55.
1998: Job L C van Susante; Pieter Buma; G N Homminga; Wim B van den Berg; R P H Veth
Chondrocyte-seeded hydroxyapatite for repair of large articular cartilage defects. A pilot study in the goat.
Biomaterials 1998;19(24):2367-74.
1998: Peter van der Kraan; Elly L Vitters; Tineke Meijers; A Robin Poole; Wim B van den Berg
Collagen type I antisense and collagen type IIA messenger RNA is expressed in adult murine articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(6):417-26.
1998: Henk M van Beuningen; Harrie L Glansbeek; Peter van der Kraan; Wim B van den Berg
Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(5):306-17.
1998: S Kuiper; Leo A B Joosten; Alison M Bendele; Carl K Edwards; Onno J Arntz; Monique M A Helsen; Fons A J van de Loo; Wim B van den Berg
Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis.
Cytokine 1998;10(9):690-702.
1998: P L E M van Lent; A E M Holthuysen; N Van Rooijen; L B A Van De Putte; Wim B van den Berg
Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis.
Annals of the rheumatic diseases 1998;57(7):408-13.
1998: P L E M van Lent; A E M Holthuysen; N van Rooijen; Fons A J van de Loo; L B A Van De Putte; Wim B van den Berg
Phagocytic synovial lining cells regulate acute and chronic joint inflammation after antigenic exacerbation of smouldering experimental murine arthritis.
The Journal of rheumatology 1998;25(6):1135-45.
1998: G J van Osch; Wim B van den Berg; E B Hunziker; H J Häuselmann
Differential effects of IGF-1 and TGF beta-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(3):187-95.
1998: Erik Lubberts; Leo A B Joosten; Monique M A Helsen; Wim B van den Berg
Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone.
Cytokine 1998;10(5):361-9.
1998: JB Van Meurs; P L E M van Lent; Irwin I Singer; Ellen K Bayne; Fons A J van de Loo; Wim B van den Berg
Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis.
Arthritis and rheumatism 1998;41(4):647-56.
1998: Fons A J van de Loo; Onno J Arntz; F H van Enckevort; P L E M van Lent; Wim B van den Berg
Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation.
Arthritis and rheumatism 1998;41(4):634-46.
1998: Harrie L Glansbeek; Henk M van Beuningen; Elly L Vitters; Peter van der Kraan; Wim B van den Berg
Expression of recombinant human soluble type II transforming growth factor-beta receptor in Pichia pastoris and Escherichia coli: two powerful systems to express a potent inhibitor of transforming growth factor-beta.
Protein expression and purification 1998;12(2):201-7.
1998: Harrie L Glansbeek; Henk M van Beuningen; Elly L Vitters; Peter van der Kraan; Wim B van den Berg
Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints.
Laboratory investigation; a journal of technical methods and pathology 1998;78(2):133-42.
1997: Pierre Miossec; Wim B van den Berg
Th1/Th2 cytokine balance in arthritis.
Arthritis and rheumatism 1997;40(12):2105-15.
1997: Leo A B Joosten; Erik Lubberts; Monique M A Helsen; Wim B van den Berg
Dual role of IL-12 in early and late stages of murine collagen type II arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):4094-102.
1997: Fons A J van de Loo; Onno J Arntz; Wim B van den Berg
Effect of interleukin 1 and leukaemia inhibitory factor on chondrocyte metabolism in articular cartilage from normal and interleukin-6-deficient mice: role of nitric oxide and IL-6 in the suppression of proteoglycan synthesis.
Cytokine 1997;9(7):453-62.
1997: Fons A J van de Loo; S Kuiper; F H van Enckevort; Onno J Arntz; Wim B van den Berg
Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice.
The American journal of pathology 1997;151(1):177-91.
1997: Harrie L Glansbeek; Henk M van Beuningen; Elly L Vitters; E A Morris; Peter van der Kraan; Wim B van den Berg
Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content.
Arthritis and rheumatism 1997;40(6):1020-8.
1997: P J Verschure; J Van Marle; C J Van Noorden; Wim B van den Berg
The contribution of quantitative confocal laser scanning microscopy in cartilage research: chondrocyte insulin-like growth factor-1 receptors in health and pathology.
Microscopy research and technique 1997;37(4):285-98.
1997: Wim B van den Berg
Lessons for joint destruction from animal models.
Current opinion in rheumatology 1997;9(3):221-8.
1997: Harrie L Glansbeek; Peter van der Kraan; F P Lafeber; Elly L Vitters; Wim B van den Berg
Species-specific expression of type II TGF-beta receptor isoforms by articular chondrocytes: effect of proteoglycan depletion and aging.
Cytokine 1997;9(5):347-51.
1997: Andrew C Bakker; Leo A B Joosten; Onno J Arntz; Monique M A Helsen; Alison M Bendele; Fons A J van de Loo; Wim B van den Berg
Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee.
Arthritis and rheumatism 1997;40(5):893-900.
1997: P L E M van Lent; A Blom; A E M Holthuysen; C W Jacobs; L B A Van De Putte; Wim B van den Berg
Monocytes/macrophages rather than PMN are involved in early cartilage degradation in cationic immune complex arthritis in mice.
Journal of leukocyte biology 1997;61(3):267-78.
1997: Peter van der Kraan; Harrie L Glansbeek; Elly L Vitters; Wim B van den Berg
Early elevation of transforming growth factor-beta, decorin, and biglycan mRNA levels during cartilage matrix restoration after mild proteoglycan depletion.
The Journal of rheumatology 1997;24(3):543-9.
1997: Leo A B Joosten; Erik Lubberts; P Durez; Monique M A Helsen; M J Jacobs; M Goldman; Wim B van den Berg
Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction.
Arthritis and rheumatism 1997;40(2):249-60.
1997: JB Van Meurs; P L E M van Lent; L A Joosten; Peter van der Kraan; Wim B van den Berg
Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RT-PCR: kinetics of stromelysin and IL-1 mRNA levels during arthritis.
Rheumatology international 1997;16(5):197-205.
1996: P J Verschure; C J Van Noorden; J Van Marle; Wim B van den Berg
Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chondrocytes.
The Histochemical journal 1996;28(12):835-57.
1996: Wim B van den Berg; P L E M van Lent
The role of macrophages in chronic arthritis.
Immunobiology 1996;195(4-5):614-23.
1996: P L E M van Lent; A E M Holthuysen; L A van den Bersselaar; N van Rooijen; Leo A B Joosten; Fons A J van de Loo; L B A Van De Putte; Wim B van den Berg
Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis.
Arthritis and rheumatism 1996;39(9):1545-55.
1996: Gerjo J V M van Osch; Peter van der Kraan; Leendert Blankevoort; Rik Huiskes; Wim B van den Berg
Relation of ligament damage with site specific cartilage loss and osteophyte formation in collagenase induced osteoarthritis in mice.
The Journal of rheumatology 1996;23(7):1227-32.
1996: Leo A B Joosten; Monique M A Helsen; Fons A J van de Loo; Wim B van den Berg
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra.
Arthritis and rheumatism 1996;39(5):797-809.
1996: Gerjo J V M van Osch; Peter van der Kraan; AA van Valburg; Wim B van den Berg
The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee.
Rheumatology international 1996;16(3):115-9.
1996: P J Verschure; J Van Marle; Leo A B Joosten; Wim B van den Berg
Histochemical analysis of insulin-like growth factor-1 binding sites in mouse normal and experimentally induced arthritic articular cartilage.
The Histochemical journal 1996;28(1):13-23.
1996: AA van Valburg; Gerjo J V M van Osch; Peter van der Kraan; Wim B van den Berg
Quantification of morphometric changes in murine experimental osteoarthritis using image analysis.
Rheumatology international 1996;15(5):181-7.
1995: P L E M van Lent; Fons A J van de Loo; A E M Holthuysen; L A Van Den Bersselaar; H Vermeer; Wim B van den Berg
Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice.
The Journal of rheumatology 1995;22(12):2250-8.
1995: P J Verschure; Leo A B Joosten; Fons A J van de Loo; Wim B van den Berg
IL-1 has no direct role in the IGF-1 non-responsive state during experimentally induced arthritis in mouse knee joints.
Annals of the rheumatic diseases 1995;54(12):976-82.
1995: Gerjo J V M van Osch; Leendert Blankevoort; Peter van der Kraan; B Janssen; E Hekman; Rik Huiskes; Wim B van den Berg
Laxity characteristics of normal and pathological murine knee joints in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1995;13(5):783-91.
1995: P J Verschure; J van Marle; Leo A B Joosten; Wim B van den Berg
Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally induced arthritis.
Annals of the rheumatic diseases 1995;54(8):645-53.
1995: L Schuman; Pieter Buma; D Versleyen; B de Man; Peter van der Kraan; Wim B van den Berg; G N Homminga
Chondrocyte behaviour within different types of collagen gel in vitro.
Biomaterials 1995;16(10):809-14.
1995: Fons A J van de Loo; Leo A B Joosten; P L E M van Lent; Onno J Arntz; Wim B van den Berg
Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis.
Arthritis and rheumatism 1995;38(2):164-72.
1995: Wim B van den Berg
Growth factors in experimental osteoarthritis: transforming growth factor beta pathogenic?
The Journal of rheumatology. Supplement 1995;43():143-5.
1995: A A van de Loo; Onno J Arntz; Andrew C Bakker; P L E M van Lent; M J Jacobs; Wim B van den Berg
Role of interleukin 1 in antigen-induced exacerbations of murine arthritis.
The American journal of pathology 1995;146(1):239-49.
1995: P L E M van Lent; A E M Holthuysen; L van den Bersselaar; N van Rooijen; L B A Van De Putte; Wim B van den Berg
Role of macrophage-like synovial lining cells in localization and expression of experimental arthritis.
Scandinavian journal of rheumatology. Supplement 1995;101():83-9.
1995: Wim B van den Berg
Articular cartilage: cause or victim in arthritis.
Scandinavian journal of rheumatology. Supplement 1995;101():31-7.
1994: J Kool; H De Visser; M Y Gerrits-Boeye; I S Klasen; Marie-José Melief; C G Van Helden-Meeuwsen; Lisette van Lieshout; Johanneke G H Ruseler-van Embden; Wim B van den Berg; G M Bahr
Detection of intestinal flora-derived bacterial antigen complexes in splenic macrophages of rats.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(11):1435-41.
1994: M J Jacobs; A E van den Hoek; P L E M van Lent; Fons A J van de Loo; L B A Van De Putte; Wim B van den Berg
Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis.
Immunology 1994;83(3):390-6.
1994: A G van de Langerijt; I Huitinga; Leo A B Joosten; C D Dijkstra; P L E M van Lent; Wim B van den Berg
Role of beta 2 integrins in the recruitment of phagocytic cells in joint inflammation in the rat.
Clinical immunology and immunopathology 1994;73(1):123-31.
1994: Peter van der Kraan; J de Lange; Elly L Vitters; Henk M van Beuningen; Gerjo J V M van Osch; P L E M van Lent; Wim B van den Berg
Analysis of changes in proteoglycan content in murine articular cartilage using image analysis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1994;2(3):207-14.
1994: Henk M van Beuningen; Peter van der Kraan; Onno J Arntz; Wim B van den Berg
In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences.
Annals of the rheumatic diseases 1994;53(9):593-600.
1994: Henk M van Beuningen; Peter van der Kraan; Onno J Arntz; Wim B van den Berg
Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint.
Laboratory investigation; a journal of technical methods and pathology 1994;71(2):279-90.
1994: Leo A B Joosten; Monique M A Helsen; Wim B van den Berg
Accelerated onset of collagen-induced arthritis by remote inflammation.
Clinical and experimental immunology 1994;97(2):204-11.
1994: A G van de Langerijt; P L E M van Lent; A R Hermus; C G J Sweep; Alexander R Cools; Wim B van den Berg
Susceptibility to adjuvant arthritis: relative importance of adrenal activity and bacterial flora.
Clinical and experimental immunology 1994;97(1):33-8.
1994: P J Verschure; Leo A B Joosten; Peter van der Kraan; Wim B van den Berg
Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors.
Annals of the rheumatic diseases 1994;53(7):455-60.
1994: P J Verschure; J van Marle; Leo A B Joosten; Wim B van den Berg
Localization and quantification of the insulin-like growth factor-1 receptor in mouse articular cartilage by confocal laser scanning microscopy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(6):765-73.
1994: Gerjo J V M van Osch; Peter van der Kraan; Wim B van den Berg
Site specific inhibition of cartilage proteoglycan synthesis in the murine knee joint. Differences between 3 metabolic stimuli.
The Journal of rheumatology 1994;21(6):1107-12.
1994: M J Jacobs; A E van den Hoek; L B A Van De Putte; Wim B van den Berg
Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance.
Immunology 1994;82(2):294-300.
1994: A G van de Langerijt; A E Kingston; P L E M van Lent; M E Billingham; Wim B van den Berg
Cross-reactivity to proteoglycans in bacterial arthritis: lack of evidence for in vivo role in induction of disease.
Clinical immunology and immunopathology 1994;71(3):273-80.
1994: P J Verschure; Peter van der Kraan; Elly L Vitters; Wim B van den Berg
Stimulation of proteoglycan synthesis by triamcinolone acetonide and insulin-like growth factor 1 in normal and arthritic murine articular cartilage.
The Journal of rheumatology 1994;21(5):920-6.
1994: A A van de Loo; Onno J Arntz; I G Otterness; Wim B van den Berg
Proteoglycan loss and subsequent replenishment in articular cartilage after a mild arthritic insult by IL-1 in mice: impaired proteoglycan turnover in the recovery phase.
Agents and actions 1994;41(3-4):200-8.
1994: M J Jacobs; A E van den Hoek; L B A Van De Putte; Wim B van den Berg
Suppression of hen egg lysozyme-induced arthritis by intravenous antigen administration: no role in this for antigen-driven bystander suppression.
Clinical and experimental immunology 1994;96(1):36-42.
1994: A G Van de Langerijt; Stephen G Volsen; C A Hicks; Peter J Craig; M E Billingham; Wim B van den Berg
Cell migration studies in the adoptive transfer of adjuvant arthritis in the Lewis rat.
Immunology 1994;81(3):414-9.
1994: Gerjo J V M van Osch; Peter van der Kraan; Wim B van den Berg
Site-specific cartilage changes in murine degenerative knee joint disease induced by iodoacetate and collagenase.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(2):168-75.
1994: Wim B van den Berg; Leo A B Joosten; Monique M A Helsen; Fons A J van de Loo
Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment.
Clinical and experimental immunology 1994;95(2):237-43.
1994: P L E M van Lent; A E van den Hoek; L A van den Bersselaar; Fons A J van de Loo; H E Eykholt; W F Brouwer; L B A Van De Putte; Wim B van den Berg
Early cartilage degradation in cationic immune complex arthritis in mice: relative role of interleukin 1, the polymorphonuclear cell (PMN) and PMN elastase.
The Journal of rheumatology 1994;21(2):321-9.
1993: M J Jacobs; A E van den Hoek; L B A Van De Putte; Wim B van den Berg
Induction of tolerance by T-cell vaccination is possible beyond the area of autoimmunity: down-regulation of immunity directed to foreign protein antigens.
Immunology 1993;80(4):511-7.
1993: Henk M van Beuningen; Onno J Arntz; Wim B van den Berg
Insulin-like growth factor stimulation of articular chondrocyte proteoglycan synthesis. Availability and responses at different ages.
British journal of rheumatology 1993;32(12):1037-43.
1993: Harrie L Glansbeek; Peter van der Kraan; Elly L Vitters; Wim B van den Berg
Correlation of the size of type II transforming growth factor beta (TGF-beta) receptor with TGF-beta responses of isolated bovine articular chondrocytes.
Annals of the rheumatic diseases 1993;52(11):812-6.
1993: Wim B van den Berg; Gerjo J V M van Osch; Peter van der Kraan; Henk M van Beuningen
Cartilage destruction and osteophytes in instability-induced murine osteoarthritis: role of TGF beta in osteophyte formation?
Agents and actions 1993;40(3-4):215-9.
1993: A G van de Langerijt; P L E M van Lent; A R Hermus; L B A Van De Putte; Wim B van den Berg
Regulation of resistance against adjuvant arthritis in the Fisher rat.
Clinical and experimental immunology 1993;94(1):150-5.
1993: F H J van den Hoogen; Peter van der Kraan; AM Boerbooms; Wim B van den Berg; H J van Lier; L B A Van De Putte
Effects of methotrexate on glycosaminoglycan production by scleroderma fibroblasts in culture.
Annals of the rheumatic diseases 1993;52(10):758-61.
1993: Peter van der Kraan; Elly L Vitters; N S Postma; J Verbunt; Wim B van den Berg
Maintenance of the synthesis of large proteoglycans in anatomically intact murine articular cartilage by steroids and insulin-like growth factor I.
Annals of the rheumatic diseases 1993;52(10):734-41.
1993: P L E M van Lent; A E Van den Hoek; L A Van den Bersselaar; M F Spanjaards; N Van Rooijen; C D Dijkstra; L B A Van De Putte; Wim B van den Berg
In vivo role of phagocytic synovial lining cells in onset of experimental arthritis.
The American journal of pathology 1993;143(4):1226-37.
1993: G N Homminga; Pieter Buma; H W Koot; Peter van der Kraan; Wim B van den Berg
Chondrocyte behavior in fibrin glue in vitro.
Acta orthopaedica Scandinavica 1993;64(4):441-5.
1993: Gerjo J V M van Osch; Peter van der Kraan; Elly L Vitters; Leendert Blankevoort; Wim B van den Berg
Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1993;1(3):171-7.
1993: Gerjo J V M van Osch; Peter van der Kraan; Wim B van den Berg
In vivo quantification of proteoglycan synthesis in articular cartilage of different topographical areas in the murine knee joint.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1993;11(4):492-9.
1993: Henk M van Beuningen; Peter van der Kraan; Onno J Arntz; Wim B van den Berg
Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo.
Annals of the rheumatic diseases 1993;52(3):185-91.
1993: P L E M van Lent; L van den Bersselaar; A E van den Hoek; M van de Ende; C D Dijkstra; N van Rooijen; L B A Van De Putte; Wim B van den Berg
Reversible depletion of synovial lining cells after intra-articular treatment with liposome-encapsulated dichloromethylene diphosphonate.
Rheumatology international 1993;13(1):21-30.
1993: Wim B van den Berg; Fons A J van de Loo; P L E M van Lent; Leo A B Joosten
Mechanisms of cartilage destruction in joint inflammation.
Agents and actions. Supplements 1993;39():49-60.
1993: Henk M van Beuningen; Peter van der Kraan; Onno J Arntz; Wim B van den Berg
Does TGF-beta protect articular cartilage in vivo?
Agents and actions. Supplements 1993;39():127-31.
1993: M J Jacobs; A E van den Hoek; L B A Van De Putte; Wim B van den Berg
Aberrant tolerance induction with cationic antigens.
Scandinavian journal of immunology 1993;37(1):97-103.
1993: Harrie L Glansbeek; Peter van der Kraan; Elly L Vitters; Wim B van den Berg
Variable TGF-beta receptor expression regulates TGF-beta responses of articular chondrocytes.
Agents and actions. Supplements 1993;39():139-45.
1993: P L E M van Lent; A E van den Hoek; L van den Bersselaar; N van Rooijen; Wim B van den Berg
Role of phagocytic synovial lining cells in experimental arthritis.
Agents and actions 1993;38 Spec No():C92-4.
1993: Fons A J van de Loo; Onno J Arntz; I G Otterness; Wim B van den Berg
Modulation of cartilage destruction in murine arthritis with anti-IL-1 antibodies.
Agents and actions 1993;39 Spec No():C211-4.
1992: M F van den Broek; Emile de Heer; M C van Bruggen; G de Roo; K Kleiverda; F Eulderink; Wim B van den Berg
Immunomodulation of streptococcal cell wall-induced arthritis. Identification of inflammatory cells and regulatory T cell subsets by mercuric chloride and in vivo CD8 depletion.
European journal of immunology 1992;22(12):3091-5.
1992: P L E M van Lent; L A van den Bersselaar; A E van den Hoek; A A van de Loo; Wim B van den Berg
Cationic immune complex arthritis in mice--a new model. Synergistic effect of complement and interleukin-1.
The American journal of pathology 1992;140(6):1451-61.
1992: Floris P J G Lafeber; Peter van der Kraan; H L van Roy; Elly L Vitters; O Huber-Bruning; Wim B van den Berg; J W J Bijlsma
Local changes in proteoglycan synthesis during culture are different for normal and osteoarthritic cartilage.
The American journal of pathology 1992;140(6):1421-9.
1992: Peter van der Kraan; Elly L Vitters; Henk M van Beuningen; Wim B van den Berg
Proteoglycan synthesis and osteophyte formation in 'metabolically' and 'mechanically' induced murine degenerative joint disease: an in-vivo autoradiographic study.
International journal of experimental pathology 1992;73(3):335-50.
1992: Peter van der Kraan; Elly L Vitters; Wim B van den Berg
Inhibition of proteoglycan synthesis by transforming growth factor beta in anatomically intact articular cartilage of murine patellae.
Annals of the rheumatic diseases 1992;51(5):643-7.
1992: M F van den Broek; M C van Bruggen; J P Koopman; M P Hazenberg; Wim B van den Berg
Gut flora induces and maintains resistance against streptococcal cell wall-induced arthritis in F344 rats.
Clinical and experimental immunology 1992;88(2):313-7.
1992: Fons A J van de Loo; Onno J Arntz; I G Otterness; Wim B van den Berg
Protection against cartilage proteoglycan synthesis inhibition by antiinterleukin 1 antibodies in experimental arthritis.
The Journal of rheumatology 1992;19(3):348-56.
1992: A A van de Loo; Onno J Arntz; Wim B van den Berg
Flare-up of experimental arthritis in mice with murine recombinant IL-1.
Clinical and experimental immunology 1992;87(2):196-202.
1992: I S Klasen; J Kool; Marie-José Melief; I Loeve; Wim B van den Berg; A J Severijnen; MP Hazenberg
Arthritis by autoreactive T cell lines obtained from rats after injection of intestinal bacterial cell wall fragments.
Cellular immunology 1992;139(2):455-67.
1992: P L E M van Lent; A Van den Hoek; L Van den Bersselaar; C D Dijkstra; N Van Rooijen; Wim B van den Berg
Role of synovial macrophages in experimental arthritis.
Research in immunology 1992;143(2):229-34.
1992: M F Van den Broek; L G Van de Langerijt; M C Van Bruggen; M E Billingham; Wim B van den Berg
Treatment of rats with monoclonal anti-CD4 induces long-term resistance to streptococcal cell wall-induced arthritis.
European journal of immunology 1992;22(1):57-61.
1992: Peter van der Kraan; Elly L Vitters; Wim B van den Berg
Differential effect of transforming growth factor beta on freshly isolated and cultured articular chondrocytes.
The Journal of rheumatology 1992;19(1):140-5.
1991: J Kool; Johanneke G H Ruseler-van Embden; Lisette van Lieshout; H de Visser; M Y Gerrits-Boeye; Wim B van den Berg; MP Hazenberg
Induction of arthritis in rats by soluble peptidoglycan-polysaccharide complexes produced by human intestinal flora.
Arthritis and rheumatism 1991;34(12):1611-6.
1991: M C van Bruggen; M F van den Broek; Wim B van den Berg
Streptococcal cell wall-induced arthritis and adjuvant arthritis in F344----Lewis and in Lewis----F344 bone marrow chimeras.
Cellular immunology 1991;136(2):278-90.
1991: Henk M van Beuningen; Onno J Arntz; Wim B van den Berg
In vivo effects of interleukin-1 on articular cartilage. Prolongation of proteoglycan metabolic disturbances in old mice.
Arthritis and rheumatism 1991;34(5):606-15.
1991: P L E M van Lent; Fons A J van de Loo; L van den Bersselaar; Wim B van den Berg
Chondrocyte nonresponsiveness of arthritic articular cartilage caused by short term immobilization.
The Journal of rheumatology 1991;18(5):709-15.
1991: Leo A B Joosten; Monique M A Helsen; Wim B van den Berg
Transient chondrocyte nonresponsiveness to insulin-like growth factor-1 upon H2O2 exposure is not related to IGF receptor damage.
The Journal of rheumatology 1991;18(4):585-90.
1991: A A Grandia; H de Visser; J D van Embden; R van der Zee; Wim B van den Berg; MP Hazenberg
Natural antibodies to 65 kD mycobacterial heat shock protein in rats do not correlate with susceptibility for Mycobacterium tuberculosis induced adjuvant arthritis.
Immunobiology 1991;182(2):127-34.
1991: Wim B van den Berg
Impact of NSAID and steroids on cartilage destruction in murine antigen induced arthritis.
The Journal of rheumatology. Supplement 1991;27():122-3.
1991: Wim B van den Berg; Fons A J van de Loo; I Otterness; Onno J Arntz; Leo A B Joosten
In vivo evidence for a key role of IL-1 in cartilage destruction in experimental arthritis.
Agents and actions. Supplements 1991;32():159-63.
1991: P L E M van Lent; Leo A B Joosten; L van den Bersselaar; Wim B van den Berg
Role of PMN in early cartilage destruction.
Agents and actions 1991;32(1-2):94-5.
1990: Leo A B Joosten; Monique M A Helsen; Wim B van den Berg
Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonide.
Agents and actions 1990;31(1-2):135-42.
1990: Joost Schalkwijk; Leo A B Joosten; Wim B van den Berg; L B A Van De Putte
Antigen induced arthritis in beige (Chediak-Higashi) mice.
Annals of the rheumatic diseases 1990;49(8):607-10.
1990: Peter van der Kraan; Elly L Vitters; B J de Vries; Wim B van den Berg
High susceptibility of human articular cartilage glycosaminoglycan synthesis to changes in inorganic sulfate availability.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1990;8(4):565-71.
1990: P L E M van Lent; L van den Bersselaar; L B A Van De Putte; Wim B van den Berg
Immobilization aggravates cartilage damage during antigen-induced arthritis in mice. Attachment of polymorphonuclear leukocytes to articular cartilage.
The American journal of pathology 1990;136(6):1407-16.
1990: A A van de Loo; Wim B van den Berg
Effects of murine recombinant interleukin 1 on synovial joints in mice: measurement of patellar cartilage metabolism and joint inflammation.
Annals of the rheumatic diseases 1990;49(4):238-45.
1990: Peter van der Kraan; Elly L Vitters; B J de Vries; Wim B van den Berg; L B A Van De Putte
The effect of chronic paracetamol administration to rats on the glycosaminoglycan content of patellar cartilage.
Agents and actions 1990;29(3-4):218-23.
1990: B J de Vries; Wim B van den Berg
Impact of NSAIDS on murine antigen induced arthritis. II. A light microscopic investigation of antiinflammatory and bone protective effects.
The Journal of rheumatology 1990;17(3):295-303.
1990: B J de Vries; Peter van der Kraan; Wim B van den Berg
Decrease of inorganic blood sulfate following treatment with selected antirheumatic drugs: potential consequence for articular cartilage.
Agents and actions 1990;29(3-4):224-31.
1990: M F van den Broek; M C van Bruggen; S A Stimpson; A J Severijnen; L B A Van De Putte; Wim B van den Berg
Flare-up reaction of streptococcal cell wall induced arthritis in Lewis and F344 rats: the role of T lymphocytes.
Clinical and experimental immunology 1990;79(2):297-306.
1990: Peter van der Kraan; Elly L Vitters; Henk M van Beuningen; L B A Van De Putte; Wim B van den Berg
Degenerative knee joint lesions in mice after a single intra-articular collagenase injection. A new model of osteoarthritis.
Journal of experimental pathology (Oxford, England) 1990;71(1):19-31.
1990: P L E M van Lent; L van den Bersselaar; Wim B van den Berg
Allergic arthritis induced by cationic proteins.
Agents and actions 1990;29(1-2):98-9.
1990: Leo A B Joosten; Monique M A Helsen; Wim B van den Berg
Inflammation-mediated chondrocyte unresponsiveness to insulin-like growth factor-1 is not caused by H2O2.
Agents and actions 1990;29(1-2):100-2.
1989: P Faaber; L A van den Bersselaar; L B A Van De Putte; Wim B van den Berg
Immune complex formation between IgM rheumatoid factor and IgG generated by hyaluronic acid.
Arthritis and rheumatism 1989;32(12):1521-7.
1989: Peter van der Kraan; Elly L Vitters; L B A Van De Putte; Wim B van den Berg
Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints.
The American journal of pathology 1989;135(6):1001-14.
1989: P L E M van Lent; F H Wilms; Wim B van den Berg
Interaction of polymorphonuclear leucocytes with patellar cartilage of immobilised arthritic joints: a scanning electron microscopic study.
Annals of the rheumatic diseases 1989;48(10):832-7.
1989: P L E M van Lent; L van den Bersselaar; G J Grutters; Wim B van den Berg
Fate of antigen after intravenous and intraarticular injection into mice. Role of molecular weight and charge.
The Journal of rheumatology 1989;16(10):1295-303.
1989: P Faaber; L A van den Bersselaar; L B A Van De Putte; Wim B van den Berg
Circulating immune complexes and rheumatoid arthritis: the induction of immune complex formation between rheumatoid factor and IgG by polyethylene glycol.
The Journal of rheumatology 1989;16(10):1304-9.
1989: B J de Vries; Wim B van den Berg
Impact of NSAIDS on murine antigen induced arthritis. I. Investigation of antiinflammatory and chondroprotective effects.
The Journal of rheumatology. Supplement 1989;18():10-8.
1989: M F van den Broek; E J Hogervorst; M C Van Bruggen; Willem van Eden; Ruurd van der Zee; Wim B van den Berg
Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein.
The Journal of experimental medicine 1989;170(2):449-66.
1989: P L E M van Lent; C Dekker; J Mosterd; L van den Bersselaar; Wim B van den Berg
Allergic arthritis induced by cationic proteins: role of molecular weight.
Immunology 1989;67(4):447-52.
1989: Joost Schalkwijk; Leo A B Joosten; Wim B van den Berg; L B A Van De Putte
Chondrocyte nonresponsiveness to insulin-like growth factor 1 in experimental arthritis.
Arthritis and rheumatism 1989;32(7):894-900.
1989: Henk M van Beuningen; Wim B van den Berg; Joost Schalkwijk; Onno J Arntz; L B A Van De Putte
Age- and sex-related differences in antigen-induced arthritis in C57Bl/10 mice.
Arthritis and rheumatism 1989;32(6):789-94.
1989: I S Klasen; R M Ladestein; Wim B van den Berg; Robbert Benner
Requirements for flare reactions of joint inflammation induced in mice by cloned MT4+, Lyt-2- T cells.
Arthritis and rheumatism 1989;32(3):330-7.
1989: Joost Schalkwijk; Leo A B Joosten; Wim B van den Berg; Judson Vanwyk; L B A Van De Putte
Insulin-like growth factor stimulation of chondrocyte proteoglycan synthesis by human synovial fluid.
Arthritis and rheumatism 1989;32(1):66-71.
1989: P L E M van Lent; A A van de Loo; L van den Bersselaar; Wim B van den Berg
Short-term immobilization restores and prevents inhibition of chondrocyte synthesis caused by IL-1.
Agents and actions 1989;26(1-2):191-2.
1989: A A van de Loo; Henk M van Beuningen; P L E M van Lent; Wim B van den Berg
Direct effect of murine rIL-1 on cartilage metabolism in vivo.
Agents and actions 1989;26(1-2):153-5.
1989: Leo A B Joosten; Joost Schalkwijk; Wim B van den Berg; L B A Van De Putte
Chondrocyte unresponsiveness to insulin-like growth factor-1. A novel pathogenetic mechanisms for cartilage destruction in experimental arthritis.
Agents and actions 1989;26(1-2):193-5.
1989: M Raghoebar; H L Tiemessen; Wim B van den Berg; C A van Ginneken
Modes of association of indometacin with human polymorphonuclear leucocytes.
Pharmacology 1989;39(6):350-61.
1989: Peter van der Kraan; B J de Vries; Elly L Vitters; Wim B van den Berg; L B A Van De Putte
The effect of low sulfate concentrations on the glycosaminoglycan synthesis in anatomically intact articular cartilage of the mouse.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1989;7(5):645-53.
1989: M Raghoebar; Wim B van den Berg; C A Van Ginneken
The polymorphonuclear leukocyte: its pharmacological transport and target properties: an overview.
Drug metabolism and drug interactions 1989;7(4):351-401.
1988: Joost Schalkwijk; Leo A B Joosten; Wim B van den Berg; L B A Van De Putte
Experimental arthritis in C57black/6 normal and beige (Chediak-Higashi) mice: in vivo and in vitro observations on cartilage degradation.
Annals of the rheumatic diseases 1988;47(11):940-6.
1988: Wim B van den Berg; Fons A J van de Loo; W A Zwarts; I G Otterness
Effects of murine recombinant interleukin 1 on intact homologous articular cartilage: a quantitative and autoradiographic study.
Annals of the rheumatic diseases 1988;47(10):855-63.
1988: M F van den Broek; M C van Bruggen; L B A Van De Putte; Wim B van den Berg
T cell responses to streptococcal antigens in rats: relation to susceptibility to streptococcal cell wall-induced arthritis.
Cellular immunology 1988;116(1):216-29.
1988: Peter van der Kraan; B J de Vries; Elly L Vitters; Wim B van den Berg; L B A Van De Putte
Inhibition of glycosaminoglycan synthesis in anatomically intact rat patellar cartilage by paracetamol-induced serum sulfate depletion.
Biochemical pharmacology 1988;37(19):3683-90.
1988: M F van den Broek; Wim B van den Berg; L B A Van De Putte; A J Severijnen
Streptococcal cell wall-induced arthritis and flare-up reaction in mice induced by homologous or heterologous cell walls.
The American journal of pathology 1988;133(1):139-49.
1988: M Raghoebar; E Lindeyer; Wim B van den Berg; C A Van Ginneken
On the mechanisms of association of the macrolide antibiotic erythromycin with isolated human polymorphonuclear leucocytes.
Biochemical pharmacology 1988;37(17):3221-7.
1988: Jean van den Elsen; M F Van den Broek; I S Klasen; Wim B van den Berg
Stimulation of antigen-specific murine T cell clones in vitro with antigen-pulsed adherent cells fixed to a carrier.
Journal of immunological methods 1988;112(1):15-22.
1988: M F Van den Broek; L B A Van De Putte; Wim B van den Berg
Crohn's disease associated with arthritis: a possible role for cross-reactivity between gut bacteria and cartilage in the pathogenesis of arthritis.
Arthritis and rheumatism 1988;31(8):1077-9.
1988: M Raghoebar; J A Huisman; Wim B van den Berg; P L van Riel; C A van Ginneken
Chloroquine interaction with inflammatory human polymorphonuclear leucocytes.
Agents and actions 1988;24(3-4):331-42.
1988: M Raghoebar; Wim B van den Berg; C A Van Ginneken
Mechanisms of cell association of some non-steroidal anti-inflammatory drugs with isolated leucocytes.
Biochemical pharmacology 1988;37(7):1245-50.
1988: M F van den Broek; Wim B van den Berg; Onno J Arntz; L B A Van De Putte
Reaction of bacterium-primed murine T cells to cartilage components: a clue for the pathogenesis of arthritis?
Clinical and experimental immunology 1988;72(1):9-14.
1988: M F van den Broek; Wim B van den Berg; L B A Van De Putte
The role of mast cells in antigen induced arthritis in mice.
The Journal of rheumatology 1988;15(4):544-51.
1988: Peter van der Kraan; Elly L Vitters; B J de Vries; Wim B van den Berg; L B A Van De Putte
Synthesis of aberrant glycosaminoglycans during cartilage culture in 'sulfate free' medium.
Journal of biochemical and biophysical methods 1988;15(5):273-7.
1988: Henk M van Beuningen; Wim B van den Berg; Joost Schalkwijk; Onno J Arntz; L B A Van De Putte
Age-related changes in joint damage caused by antigen-induced arthritis in mice.
Agents and actions 1988;23(1-2):74-6.
1988: Peter van der Kraan; B J de Vries; Wim B van den Berg; Elly L Vitters; L B A Van De Putte
Effects of drug-mediated serum sulfate depletion on glycosaminoglycan synthesis.
Agents and actions 1988;23(1-2):55-7.
1988: B J de Vries; Wim B van den Berg; Elly L Vitters; L B A Van De Putte
The influence of antirheumatic drugs on basal and accelerated breakdown of articular proteoglycans.
Agents and actions 1988;23(1-2):52-4.
1988: I S Klasen; R M Ladestein; Wim B van den Berg; Robbert Benner
Flare up of joint inflammations induced by cloned helper T cells. Retention of the helper T cells.
Agents and actions 1988;23(1-2):69-73.
1988: J Schalkwijk; L A Joosten; Wim B van den Berg; L B A Van De Putte
Degradation of cartilage proteoglycans by elastase is dependent on charge-mediated interactions.
Rheumatology international 1988;8(1):27-33.
1988: Wim B van den Berg
Influence of joint inflammation on chondrocyte function.
International journal of tissue reactions 1988;10(1):17-23.
1988: B J de Vries; Wim B van den Berg; Elly L Vitters; L B A Van De Putte
Effect of nonsteroidal antiinflammatory drugs on cartilage destruction in antigen induced arthritis in mice.
Scandinavian journal of rheumatology. Supplement 1988;77():23-8.
1988: P L E M van Lent; Wim B van den Berg; L B A Van De Putte; L van den Bersselaar
Electrical charge of a protein determines penetration and localization in hyaline articular cartilage. Quantitative and autoradiographic studies on cartilage of different species, including man.
Rheumatology international 1988;8(4):145-52.
1987: M Raghoebar; Wim B van den Berg; J A Huisman; C A van Ginneken
The cellular association of sodium salicylate and indomethacin in peritoneal fluid of ascites bearing mice.
Agents and actions 1987;22(3-4):314-23.
1987: I S Klasen; R M Ladestein; I G Donselaar; Wim B van den Berg; R Tees; Robbert Benner
Joint inflammation in mice induced by a MT4+ Lyt-2- T cell clone. Characteristics and the induction of flare-up reactions.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3275-80.
1987: M Raghoebar; J A Huisman; Wim B van den Berg; C A Van Ginneken
An in vitro approach to study cellular kinetics of drugs.
Journal of pharmacological methods 1987;18(3):239-51.
1987: P L E M van Lent; Wim B van den Berg; Joost Schalkwijk; L B A Van De Putte; L van den Bersselaar
Allergic arthritis induced by cationic antigens: relationship of chronicity with antigen retention and T-cell reactivity.
Immunology 1987;62(2):265-72.
1987: P L E M van Lent; Wim B van den Berg; Joost Schalkwijk; L B A Van De Putte; L van den Bersselaar
The impact of protein size and charge on its retention in articular cartilage.
The Journal of rheumatology 1987;14(4):798-805.
1987: B J de Vries; Elly L Vitters; Wim B van den Berg; D Schram; L B A Van De Putte
Determination of small quantities of sulfate (0-12 nmol) in serum, urine, and cartilage of the mouse.
Analytical biochemistry 1987;163(2):408-17.
1987: M Raghoebar; Wim B van den Berg; C A van Ginneken
Alteration of chloroquine accumulation in human polymorphonuclear leucocytes under inflammatory conditions.
International journal of tissue reactions 1987;9(3):255-61.
1986: I S Klasen; I G Donselaar; R M Ladestein; Wim B van den Berg; Robbert Benner
Joint inflammations and flare-up reactions in mice induced by a helper T cell clone.
Agents and actions 1986;19(5-6):331-4.
1986: M Raghoebar; P A Peeters; Wim B van den Berg; C A van Ginneken
Mechanisms of cell association of chloroquine to leucocytes.
The Journal of pharmacology and experimental therapeutics 1986;238(1):302-6.
1984: M Raghoebar; H L Tiemessen; P A Peeters; Wim B van den Berg; C A van Ginneken; L B van der Putte
Association of sodium salicylate to isolated leucocytes.
Biochemical pharmacology 1984;33(18):2937-41.