Wim van den Berg

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Abdollahi-Roodsaz Shahla; Joosten Leo A B; Koenders Marije I; van den Brand Ben T; van de Loo Fons A J; van den Berg Wim B
Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation.
Geurts Jeroen; Joosten Leo A B; Takahashi Nozomi; Arntz Onno J; Glück Anton; Bennink Miranda B; van den Berg Wim B; van de Loo Fons A J
Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis.
van den Berg Wim B; Miossec Pierre
IL-17 as a future therapeutic target for rheumatoid arthritis.

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All Publications

2009: Abdollahi-Roodsaz Shahla; Joosten Leo A B; Koenders Marije I; van den Brand Ben T; van de Loo Fons A J; van den Berg Wim B
Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation.
The American journal of pathology 2009;175(5):2004-13.
2009: Geurts Jeroen; Joosten Leo A B; Takahashi Nozomi; Arntz Onno J; Glück Anton; Bennink Miranda B; van den Berg Wim B; van de Loo Fons A J
Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1877-87.
2009: van den Berg Wim B; Miossec Pierre
IL-17 as a future therapeutic target for rheumatoid arthritis.
Nature reviews. Rheumatology 2009;5(10):549-53.
2009: van Lent P L E M; Hofkens W; Blom A B; Grevers L; Sloetjes A; Takahashi N; van Tits L J; Vogl T; Roth J; de Winther M P; van den Berg W B
Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis.
Arthritis and rheumatism 2009;60(10):2954-65.
2009: Wenink Mark H; Santegoets Kim C M; Roelofs Mieke F; Huijbens Richard; Koenen Hans J P M; van Beek Ronald; Joosten Irma; Meyer-Wentrup Friederike; Mathsson Linda; Ronnelid Johan; Adema Gosse J; Bonvini Ezio; Koenig Scott; van den Berg Wim B; van Riel Piet L C M; Radstake Timothy R D J
The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4509-20.
2009: Roelofs M F; Wenink M H; Brentano F; Abdollahi-Roodsaz S; Oppers-Walgreen B; Barrera P; van Riel P L C M; Joosten L A B; Kyburz D; van den Berg W B; Radstake T R D J
Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA).
Annals of the rheumatic diseases 2009;68(9):1486-93.
2009: Blaney Davidson Esmeralda N; Remst Dennis F G; Vitters Elly L; van Beuningen Henk M; Blom Arjen B; Goumans Marie-Jose; van den Berg Wim B; van der Kraan Peter M
Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7937-45.
2009: van de Veerdonk Frank L; Marijnissen Renoud J; Kullberg Bart Jan; Koenen Hans J P M; Cheng Shih-Chin; Joosten Irma; van den Berg Wim B; Williams David L; van der Meer Jos W M; Joosten Leo A B; Netea Mihai G
The macrophage mannose receptor induces IL-17 in response to Candida albicans.
Cell host & microbe 2009;5(4):329-40.
2009: Grevers Lilyanne C; van Lent Peter L E M; Koenders Marije I; Walgreen Birgitte; Sloetjes Annet W; Nimmerjahn Falk; Sjef Verbeek J; van den Berg Wim B
Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis.
Arthritis and rheumatism 2009;60(2):396-407.
2009: Blom Arjen B; Brockbank Sarah M; van Lent Peter L; van Beuningen Henk M; Geurts Jeroen; Takahashi Nozomi; van der Kraan Peter M; van de Loo Fons A; Schreurs B Wim; Clements Kristen; Newham Peter; van den Berg Wim B
Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.
Arthritis and rheumatism 2009;60(2):501-12.
2008: van Lent P L E M; Grevers L C; Blom A B; Arntz O J; van de Loo F A J; van der Kraan P; Abdollahi-Roodsaz S; Srikrishna G; Freeze H; Sloetjes A; Nacken W; Vogl T; Roth J; van den Berg W B
Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis.
Arthritis and rheumatism 2008;58(12):3776-87.
2008: Abdollahi-Roodsaz Shahla; Joosten Leo A B; Helsen Monique M; Walgreen Birgitte; van Lent Peter L; van den Bersselaar Liduine A; Koenders Marije I; van den Berg Wim B
Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production.
Arthritis and rheumatism 2008;58(12):3753-64.
2008: Veenbergen Sharon; Bennink Miranda B; de Hooge Alfons S K; Arntz Onno J; Smeets Ruben L; van den Berg Wim B; van de Loo Fons A J
Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis.
Arthritis and rheumatism 2008;58(12):3742-52.
2008: van Lent P L E M; Grevers L; Blom A B; Sloetjes A; Mort J S; Vogl T; Nacken W; van den Berg W B; Roth J
Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis.
Annals of the rheumatic diseases 2008;67(12):1750-8.
2008: Koenders Marije I; Devesa Isabel; Marijnissen Renoud J; Abdollahi-Roodsaz Shahla; Boots Annemieke M H; Walgreen Birgitte; di Padova Franco E; Nicklin Martin J H; Joosten Leo A B; van den Berg Wim B
Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.
Arthritis and rheumatism 2008;58(11):3461-70.
2008: Takahashi Nozomi; de Jager Victor C L; Glück Anton; Letzkus Martin; Hartmann Nicole; Staedtler Frank; Ribeiro-Dias Fatima; Heuvelmans-Jacobs Marleen; van den Berg Wim B; Joosten Leo A B
The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40.
Arthritis and rheumatism 2008;58(11):3471-84.
2008: Takahashi Nozomi; van Kilsdonk Jeroen W J; Ostendorf Benedikt; Smeets Ruben; Bruggeman Sophia W M; Alonso Angel; van de Loo Fons; Schneider Matthias; van den Berg Wim B; Swart Guido W M
Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB.
Biochemical and biophysical research communications 2008;374(3):424-30.
2008: Ferrándiz M L; Maicas N; Garcia-Arnandis I; Terencio M C; Motterlini R; Devesa I; Joosten L A B; van den Berg W B; Alcaraz M J
Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis.
Annals of the rheumatic diseases 2008;67(9):1211-7.
2008: Takahashi Nozomi; Vanlaere Ineke; de Rycke Riet; Cauwels Anje; Joosten Leo A B; Lubberts Erik; van den Berg Wim B; Libert Claude
IL-17 produced by Paneth cells drives TNF-induced shock.
The Journal of experimental medicine 2008;205(8):1755-61.
2008: Joosten Leo A B; Heinhuis Bas; Abdollahi-Roodsaz Shahla; Ferwerda Gerben; Lebourhis Lionel; Philpott Dana J; Nahori Marie-Anne; Popa Calin; Morre Servaas A; van der Meer Jos W M; Girardin Stephen E; Netea Mihai G; van den Berg Wim B
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9017-22.
2008: Roelofs Mieke F; Wenink Mark H; Toonen Erik J M; Coenen Marieke J H; Joosten Leo A B; van den Berg Wim B; van Riel Piet L C M; Radstake Timothy R D J
The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis.
The Journal of rheumatology 2008;35(4):558-61.
2008: Boross Peter; van Lent Peter L; Martin-Ramirez Javier; van der Kaa Jos; Mulder Melissa H C M; Claassens Jill W C; van den Berg Wim B; Arandhara Victoria L; Verbeek J Sjef
Destructive arthritis in the absence of both FcgammaRI and FcgammaRIII.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):5083-91.
2008: van der Kraan Peter M; van den Berg Wim B
Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing.
Ageing research reviews 2008;7(2):106-13.
2008: Roelofs Mieke F; Abdollahi-Roodsaz Shahla; Joosten Leo A B; van den Berg Wim B; Radstake Timothy R D J
The orchestra of Toll-like receptors and their potential role in frequently occurring rheumatic conditions.
Arthritis and rheumatism 2008;58(2):338-48.
2008: Joosten Leo A B; Helsen Monique M A; van de Loo Fons A J; van den Berg Wim B
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra.
Arthritis and rheumatism 2008;58(2 Suppl):S110-22.
2008: van den Berg Wim B
Cytokines and joint erosion in arthritis.
Nature clinical practice. Rheumatology 2008;4(2):58-9.
2008: van den Berg Wim B
Lessons from animal models of osteoarthritis.
Current rheumatology reports 2008;10(1):26-9.
2008: Joosten Leo A B; Abdollahi-Roodsaz Shahla; Heuvelmans-Jacobs Marleen; Helsen Monique M A; van den Bersselaar Liduine A M; Oppers-Walgreen Birgitte; Koenders Marije I; van den Berg Wim B
T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17.
Arthritis and rheumatism 2008;58(1):98-108.
2008: Abdollahi-Roodsaz Shahla; Joosten Leo A B; Koenders Marije I; Devesa Isabel; Roelofs Mieke F; Radstake Timothy R D J; Heuvelmans-Jacobs Marleen; Akira Shizuo; Nicklin Martin J H; Ribeiro-Dias Fátima; van den Berg Wim B
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.
The Journal of clinical investigation 2008;118(1):205-16.
2008: Alten Rieke; Gram Hermann; Joosten Leo A; van den Berg Wim B; Sieper Joachim; Wassenberg Siegfrid; Burmester Gerd; van Riel Piet; Diaz-Lorente Maria; Bruin Gerardus J M; Woodworth Thasia G; Rordorf Christiane; Batard Yannik; Wright Andrew M; Jung Thomas
The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis.
Arthritis research & therapy 2008;10(3):R67.
2007: Blaney Davidson E N; Vitters E L; van Beuningen H M; van de Loo F A J; van den Berg W B; van der Kraan P M
Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation.
Arthritis and rheumatism 2007;56(12):4065-73.
2007: Geurts J; Arntz O J; Bennink M B; Joosten L A B; van den Berg W B; van de Loo F A J
Application of a disease-regulated promoter is a safer mode of local IL-4 gene therapy for arthritis.
Gene therapy 2007;14(23):1632-8.
2007: van den Berg Wim B; van Lent Peter L; Joosten Leo A B; Abdollahi-Roodsaz Shahla; Koenders Marije I
Amplifying elements of arthritis and joint destruction.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii45-8.
2007: Popa Calin; Abdollahi-Roodsaz Shahla; Joosten Leo A B; Takahashi Nozomi; Sprong Tom; Matera Giovanni; Liberto Maria Carla; Foca Alfredo; van Deuren Marcel; Kullberg Bart Jan; van den Berg Wim B; van der Meer Jos W M; Netea Mihai G
Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4.
Infection and immunity 2007;75(10):4831-7.
2007: Abdollahi-Roodsaz Shahla; Joosten Leo A B; Roelofs Mieke F; Radstake Timothy R D J; Matera Giovanni; Popa Calin; van der Meer Jos W M; Netea Mihai G; van den Berg Wim B
Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis.
Arthritis and rheumatism 2007;56(9):2957-67.
2007: Blaney Davidson E N; van der Kraan P M; van den Berg W B
TGF-beta and osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(6):597-604.
2007: Plater-Zyberk C; Joosten L A B; Helsen M M A; Hepp J; Baeuerle P A; van den Berg W B
GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice.
Annals of the rheumatic diseases 2007;66(4):452-7.
2007: van der Kraan Peter M; van den Berg Wim B
Osteophytes: relevance and biology.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(3):237-44.
2007: van Lent P L E M; Blom A B; Grevers L; Sloetjes A; van den Berg W B
Toll-like receptor 4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis: Toll-like receptor 4 largely regulates FcgammaR expression by interleukin 10.
Annals of the rheumatic diseases 2007;66(3):334-40.
2007: Blom Arjen B; van der Kraan Peter M; van den Berg Wim B
Cytokine targeting in osteoarthritis.
Current drug targets 2007;8(2):283-92.
2007: Blom Arjen B; van Lent Peter L; Libregts Sten; Holthuysen Astrid E; van der Kraan Peter M; van Rooijen Nico; van den Berg Wim B
Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3.
Arthritis and rheumatism 2007;56(1):147-57.
2007: van den Berg Wim B; Joosten Leo A B; van Lent Peter L E M
Murine antigen-induced arthritis.
Methods in molecular medicine 2007;136():243-53.
2007: Blaney Davidson Esmeralda N; Vitters Elly L; van Lent Peter L E M; van de Loo Fons A J; van den Berg Wim B; van der Kraan Peter M
Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling.
Arthritis research & therapy 2007;9(5):R102.
2006: van Lent Peter L; Grevers Lilyanne; Lubberts Erik; de Vries Teun J; Nabbe Karin C; Verbeek Sjef; Oppers Birgit; Sloetjes Annet; Blom Arjen B; van den Berg Wim B
Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation.
Arthritis and rheumatism 2006;54(12):3868-77.
2006: Radstake Timothy R D J; Franke Barbara; Wenink Mark H; Nabbe Karin C A M; Coenen Marieke J H; Welsing Paco; Bonvini Ezio; Koenig Scott; van den Berg Wim B; Barrera Pilar; van Riel Piet L C M
The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis.
Arthritis and rheumatism 2006;54(12):3828-37.
2006: van Lent P; Sloetjes A; Blom A; Krijger G; Koning G; Nievaart S; van den Berg W; Moss R
Selective elimination of synovial macrophages by boron neutron capture therapy prevents onset of murine experimental arthritis.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(2):e106-7.
2006: Koenders M I; Joosten L A B; van den Berg W B
Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis.
Annals of the rheumatic diseases 2006;65 Suppl 3():iii29-33.
2006: Blaney Davidson E N; Vitters E L; van der Kraan P M; van den Berg W B
Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation.
Annals of the rheumatic diseases 2006;65(11):1414-21.
2006: van de Loo Fons A J; Geurts Jeroen; van den Berg Wim B
Gene therapy works in animal models of rheumatoid arthritis...so what!
Current rheumatology reports 2006;8(5):386-93.
2006: Netea Mihai G; Joosten Leo A B; Lewis Eli; Jensen Dalan R; Voshol Peter J; Kullberg Bart Jan; Tack Cees J; van Krieken Han; Kim Soo-Hyun; Stalenhoef Anton F; van de Loo Fons A; Verschueren Ineke; Pulawa Leslie; Akira Shizuo; Eckel Robert H; Dinarello Charles A; van den Berg Wim; van der Meer Jos W M
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Nature medicine 2006;12(6):650-6.
2006: Roelofs Mieke F; Boelens Wilbert C; Joosten Leo A B; Abdollahi-Roodsaz Shahla; Geurts Jeroen; Wunderink Liza U; Schreurs B Willem; van den Berg Wim B; Radstake Timothy R D J
Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7021-7.
2006: Koenders Marije I; Lubberts Erik; van de Loo Fons A J; Oppers-Walgreen Birgitte; van den Bersselaar Liduine; Helsen Monique M; Kolls Jay K; Di Padova Franco E; Joosten Leo A B; van den Berg Wim B
Interleukin-17 acts independently of TNF-alpha under arthritic conditions.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6262-9.
2006: Smeets R L; Veenbergen S; Arntz O J; Bennink M B; Joosten L A B; van den Berg W B; van de Loo F A J
A novel role for suppressor of cytokine signaling 3 in cartilage destruction via induction of chondrocyte desensitization toward insulin-like growth factor.
Arthritis and rheumatism 2006;54(5):1518-28.
2006: Wenink M H; van den Berg W B; van Riel P L C M; Radstake T R D J
Fc gamma receptor mediated modulation of dendritic cells as a potential strategy in the battle against rheumatoid arthritis.
The Netherlands journal of medicine 2006;64(4):103-8.
2006: Joosten Leo A B; Netea Mihai G; Kim Soo-Hyun; Yoon Do-Young; Oppers-Walgreen Birgitte; Radstake Timothy R D; Barrera Pilar; van de Loo Fons A J; Dinarello Charles A; van den Berg Wim B
IL-32, a proinflammatory cytokine in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3298-303.
2006: Blaney Davidson Esmeralda N; Vitters Elly L; van den Berg Wim B; van der Kraan Peter M
TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7.
Arthritis research & therapy 2006;8(3):R65.
2005: Toh Myew-Ling; Hong Saw-See; van de Loo Fons; Franqueville Laure; Lindholm Leif; van den Berg Wim; Boulanger Pierre; Miossec Pierre
Enhancement of adenovirus-mediated gene delivery to rheumatoid arthritis synoviocytes and synovium by fiber modifications: role of arginine-glycine-aspartic acid (RGD)- and non-RGD-binding integrins.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7687-98.
2005: Radstake T R D J; Nabbe K C A M; Wenink M H; Roelofs M F; Oosterlaar A; van Lieshout A W T; Barrera P; van Lent P L E M; van den Berg W B
Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc gamma RII expression, which has clear functional consequences.
Annals of the rheumatic diseases 2005;64(12):1737-43.
2005: Radstake T R D J; van Lieshout A W T; van Riel P L C M; van den Berg W B; Adema G J
Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(11):1532-8.
2005: Koenders Marije I; Kolls Jay K; Oppers-Walgreen Birgitte; van den Bersselaar Liduine; Joosten Leo A B; Schurr Jill R; Schwarzenberger Paul; van den Berg Wim B; Lubberts Erik
Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.
Arthritis and rheumatism 2005;52(10):3239-47.
2005: Lubberts Erik; Schwarzenberger Paul; Huang Weitao; Schurr Jill R; Peschon Jacques J; van den Berg Wim B; Kolls Jay K
Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3360-8.
2005: Roelofs M F; Joosten L A B; Abdollahi-Roodsaz S; van Lieshout A W T; Sprong T; van den Hoogen F H; van den Berg W B; Radstake T R D J
The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells.
Arthritis and rheumatism 2005;52(8):2313-22.
2005: Smeets R L; Joosten L A B; Arntz O J; Bennink M B; Takahashi N; Carlsen H; Martin M U; van den Berg W B; van de Loo F A J
Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist.
Arthritis and rheumatism 2005;52(7):2202-11.
2005: Koenders Marije I; Lubberts Erik; Oppers-Walgreen Birgitte; van den Bersselaar Liduine; Helsen Monique M; Di Padova Franco E; Boots Annemieke M H; Gram Hermann; Joosten Leo A B; van den Berg Wim B
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.
The American journal of pathology 2005;167(1):141-9.
2005: Takahashi N; Rieneck K; van der Kraan P M; van Beuningen H M; Vitters E L; Bendtzen K; van den Berg W B
Elucidation of IL-1/TGF-beta interactions in mouse chondrocyte cell line by genome-wide gene expression.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(5):426-38.
2005: van der Voort Robbert; van Lieshout Antoine W T; Toonen Liza W J; Slöetjes Annet W; van den Berg Wim B; Figdor Carl G; Radstake Timothy R D J; Adema Gosse J
Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints.
Arthritis and rheumatism 2005;52(5):1381-91.
2005: Nabbe K C A M; Boross P; Holthuysen A E M; Sloëtjes A W; Kolls J K; Verbeek S; van Lent P L E M; van Den Berg W B
Joint inflammation and chondrocyte death become independent of Fcgamma receptor type III by local overexpression of interferon-gamma during immune complex-mediated arthritis.
Arthritis and rheumatism 2005;52(3):967-74.
2005: Koenders Marije I; Lubberts Erik; Oppers-Walgreen Birgitte; van den Bersselaar Liduine; Helsen Monique M; Kolls Jay K; Joosten Leo A B; van den Berg Wim B
Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1.
Arthritis and rheumatism 2005;52(3):975-83.
2005: van Lent P L E M; Span P N; Sloetjes A W; Radstake T R D J; van Lieshout A W T; Heuvel J J T M; Sweep C G J; van den Berg W B
Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(3):368-74.
2005: Radstake T R D J; van der Voort R; ten Brummelhuis M; de Waal Malefijt M; Looman M; Figdor C G; van den Berg W B; Barrera P; Adema G J
Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors.
Annals of the rheumatic diseases 2005;64(3):359-67.
2005: van Lieshout A W T; Barrera P; Smeets R L; Pesman G J; van Riel P L C M; van den Berg W B; Radstake T R D J
Inhibition of TNF alpha during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF alpha blockade in rheumatoid arthritis.
Annals of the rheumatic diseases 2005;64(3):408-14.
2005: van den Berg Wim B
Animal models of arthritis. What have we learned?
The Journal of rheumatology. Supplement 2005;72():7-9.
2005: de Hooge Alfons S K; van de Loo Fons A J; Bennink Miranda B; Arntz Onno J; de Hooge Pieter; van den Berg Wim B
Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(1):66-73.
2005: Blaney Davidson E N; Scharstuhl A; Vitters E L; van der Kraan P M; van den Berg W B
Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity.
Arthritis research & therapy 2005;7(6):R1338-47.
2005: van Lent Peter L E M; Nabbe Karin C A M; Blom Arjen B; Sloetjes Annet; Holthuysen Astrid E M; Kolls Jay; Van De Loo Fons A J; Holland Steven M; Van Den Berg Wim B
NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis.
Arthritis research & therapy 2005;7(4):R885-95.
2005: Nabbe Karin C A M; van Lent Peter L E M; Holthuysen Astrid E M; Sloëtjes Annet W; Koch Alisa E; Radstake Timothy R D J; van den Berg Wim B
Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation.
Arthritis research & therapy 2005;7(2):R392-401.
2005: Lubberts Erik; Koenders Marije I; van den Berg Wim B
The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.
Arthritis research & therapy 2005;7(1):29-37.
2004: Radstake Timothy R D J; Roelofs Mieke F; Jenniskens Yvonne M; Oppers-Walgreen Birgitte; van Riel Piet L C M; Barrera Pilar; Joosten Leo A B; van den Berg Wim B
Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.
Arthritis and rheumatism 2004;50(12):3856-65.
2004: Radstake T R D J; Blom A B; Slöetjes A W; van Gorselen E O F; Pesman G J; Engelen L; Torensma R; van den Berg W B; Figdor C G; van Lent P L E M; Adema G J; Barrera P
Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(12):1556-63.
2004: Joosten Leo A B; Smeets Ruben L; Koenders Marije I; van den Bersselaar Liduine A M; Helsen Monique M A; Oppers-Walgreen Birgitte; Lubberts Erik; Iwakura Yoichiro; van de Loo Fons A J; van den Berg Wim B
Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction.
The American journal of pathology 2004;165(3):959-67.
2004: Blom Arjen B; van Lent Peter L E M; Holthuysen Astrid E M; van der Kraan Peter M; Roth Johannes; van Rooijen Nico; van den Berg Wim B
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(8):627-35.
2004: de Hooge Alfons S K; van de Loo Fons A J; Koenders Marije I; Bennink Miranda B; Arntz Onno J; Kolbe Thomas; van den Berg Wim B
Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice.
Arthritis and rheumatism 2004;50(6):2014-23.
2004: Radstake T R D J; van Lent P L E M; Pesman G J; Blom A B; Sweep F G J; Rönnelid J; Adema G J; Barrera P; van den Berg W B
High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering.
Annals of the rheumatic diseases 2004;63(6):696-702.
2004: Metselaar J M; van den Berg W B; Holthuysen A E M; Wauben M H M; Storm G; van Lent P L E M
Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis.
Annals of the rheumatic diseases 2004;63(4):348-53.
2004: van de Loo F A J; de Hooge A S K; Smeets R L; Bakker A C; Bennink M B; Arntz O J; Joosten L A B; van Beuningen H M; van der Kraan P K; Varley A W; van den Berg W B
An inflammation-inducible adenoviral expression system for local treatment of the arthritic joint.
Gene therapy 2004;11(7):581-90.
2004: van der Kraan Peter M; van de Loo Fons A J; van den Berg Wim B
Role of gene therapy in tissue engineering procedures in rheumatology: the use of animal models.
Biomaterials 2004;25(9):1497-504.
2004: Radstake Timothy R D J; Franke Barbara; Hanssen Suzanne; Netea Mihai G; Welsing Paco; Barrera Pilar; Joosten Leo A B; van Riel Piet L C M; van den Berg Wim B
The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.
Arthritis and rheumatism 2004;50(3):999-1001.
2004: Lubberts Erik; Koenders Marije I; Oppers-Walgreen Birgitte; van den Bersselaar Liduine; Coenen-de Roo Christina J J; Joosten Leo A B; van den Berg Wim B
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion.
Arthritis and rheumatism 2004;50(2):650-9.
2004: van Lent P L E M; Blom A B; van der Kraan P; Holthuysen A E M; Vitters E; van Rooijen N; Smeets R L; Nabbe K C A M; van den Berg W B
Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation.
Arthritis and rheumatism 2004;50(1):103-11.
2004: van de Loo Fons A J; Smeets Ruben L; van den Berg Wim B
Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?
Arthritis research & therapy 2004;6(5):183-96.
2003: Scharstuhl Alwin; Vitters Elly L; van der Kraan Peter M; van den Berg Wim B
Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis.
Arthritis and rheumatism 2003;48(12):3442-51.
2003: Netea Mihai G; Vonk Alieke G; van den Hoven Mabel; Verschueren Ineke; Joosten Leo A; van Krieken Johan H; van den Berg Wim B; Van der Meer Jos W M; Kullberg Bart Jan
Differential role of IL-18 and IL-12 in the host defense against disseminated Candida albicans infection.
European journal of immunology 2003;33(12):3409-17.
2003: Joosten Leo A B; Koenders Marije I; Smeets Ruben L; Heuvelmans-Jacobs Marleen; Helsen Monique M A; Takeda Kiyoshi; Akira Shizuo; Lubberts Erik; van de Loo Fons A J; van den Berg Wim B
Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6145-53.
2003: Scharstuhl A; Diepens R; Lensen J; Vitters E; van Beuningen H; van der Kraan P; van den Berg W
Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(11):773-82.
2003: van Lent Peter; Nabbe Karin C; Boross Peter; Blom Arjen B; Roth Johannes; Holthuysen Astrid; Sloetjes Annet; Verbeek Sjef; van den Berg Wim
The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes.
The American journal of pathology 2003;163(5):1839-48.
2003: Smeets R L; van de Loo F A J; Joosten L A B; Arntz O J; Bennink M B; Loesberg W A; Dmitriev I P; Curiel D T; Martin M U; van den Berg W B
Effectiveness of the soluble form of the interleukin-1 receptor accessory protein as an inhibitor of interleukin-1 in collagen-induced arthritis.
Arthritis and rheumatism 2003;48(10):2949-58.
2003: van de Loo Fons A J; Bennink Miranda B; Arntz Onno J; Smeets Ruben L; Lubberts Erik; Joosten Leo A B; van Lent Peter L E M; Coenen-de Roo Christina J J; Cuzzocrea Salvatore; Segal Brahm H; Holland Steven M; van den Berg Wim B
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
The American journal of pathology 2003;163(4):1525-37.
2003: Vossenaar Erik R; Nijenhuis Suzanne; Helsen Monique M A; van der Heijden Annemarie; Senshu Tatsuo; van den Berg Wim B; van Venrooij Walther J; Joosten Leo A B
Citrullination of synovial proteins in murine models of rheumatoid arthritis.
Arthritis and rheumatism 2003;48(9):2489-500.
2003: Nabbe Karin C; van Lent Peter L; Holthuysen Astrid E; Kolls Jay K; Verbeek Sjef; van den Berg Wim B
FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis.
The American journal of pathology 2003;163(2):743-52.
2003: Buma Pieter; Pieper Jeroen S; van Tienen Tony; van Susante Job L C; van der Kraan Peter M; Veerkamp Jacques H; van den Berg Wim B; Veth Rene P H; van Kuppevelt Toin H
Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects--a study in rabbits.
Biomaterials 2003;24(19):3255-63.
2003: de Hooge Alfons S K; van de Loo Fons A J; Bennink Miranda B; Arntz Onno J; Fiselier Theo J W; Franssen Marcel J A M; Joosten Leo A B; Van Lent Peter L E M; Richards Carl D; van den Berg Wim B
Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient mice.
Arthritis and rheumatism 2003;48(6):1750-61.
2003: Smeets R L; van de Loo F A J; Arntz O J; Bennink M B; Joosten L A B; van den Berg W B
Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice.
Gene therapy 2003;10(12):1004-11.
2003: Blom A B; van Lent P L E M; Holthuysen A E M; Jacobs C; van den Berg W B
Skewed balance in basal expression and regulation of activating v inhibitory Fcgamma receptors in macrophages of collagen induced arthritis sensitive mice.
Annals of the rheumatic diseases 2003;62(5):465-71.
2003: Blom Arjen B; Radstake Timothy R D J; Holthuysen Astrid E M; Slöetjes Annet W; Pesman Gerard J; Sweep Fred G J; van de Loo Fons A J; Joosten L A B; Barrera Pilar; van Lent Peter L E M; van den Berg Wim B
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
Arthritis and rheumatism 2003;48(4):1002-14.
2003: Scharstuhl Alwin; Glansbeek Harrie; Vitters Elly L; van der Kraan Peter M; van den Berg Wim B
Large scale protein production of the extracellular domain of the transforming growth factor-beta type II receptor using the Pichia pastoris expression system.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;786(1-2):271-7.
2003: Lubberts Erik; van den Bersselaar Liduine; Oppers-Walgreen Birgitte; Schwarzenberger Paul; Coenen-de Roo Christina J J; Kolls Jay K; Joosten Leo A B; van den Berg Wim B
IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2655-62.
2003: van Lent Peter L E M; Figdor Carl G; Barrera Pilar; van Ginkel Karin; Slöetjes Annet; van den Berg Wim B; Torensma Ruurd
Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells.
Arthritis and rheumatism 2003;48(2):360-9.
2003: Joosten Leo A B; Radstake Timothy R D; Lubberts Erik; van den Bersselaar Liduine A M; van Riel Piet L C M; van Lent Peter L E M; Barrera Pilar; van den Berg Wim B
Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis.
Arthritis and rheumatism 2003;48(2):339-47.
2003: Nabbe K C A M; Blom A B; Holthuysen A E M; Boross P; Roth J; Verbeek S; van Lent P L E M; van den Berg W B
Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis.
Arthritis and rheumatism 2003;48(1):255-65.
2003: Lubberts Erik; van den Berg Wim B
Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritis.
Advances in experimental medicine and biology 2003;520():194-202.
2002: van Beuningen H M; Stoop R; Buma P; Takahashi N; van der Kraan P M; van den Berg W B
Phenotypic differences in murine chondrocyte cell lines derived from mature articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(12):977-86.
2002: Scharstuhl A; van Beuningen H M; Vitters E L; van der Kraan P M; van den Berg W B
Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice.
Annals of the rheumatic diseases 2002;61(12):1095-8.
2002: Lubberts Erik; Oppers-Walgreen Birgitte; Pettit Allison R; Van Den Bersselaar Liduine; Joosten Leo A B; Goldring Steven R; Gravallese Ellen M; Van Den Berg Wim B
Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis.
Arthritis and rheumatism 2002;46(11):3055-64.
2002: van der Kraan P M; Buma P; van Kuppevelt T; van den Berg W B
Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(8):631-7.
2002: Pieper J S; van der Kraan P M; Hafmans T; Kamp J; Buma P; van Susante J L C; van den Berg W B; Veerkamp J H; van Kuppevelt T H
Crosslinked type II collagen matrices: preparation, characterization, and potential for cartilage engineering.
Biomaterials 2002;23(15):3183-92.
2002: Scharstuhl Alwin; Glansbeek Harrie L; van Beuningen Henk M; Vitters Elly L; van der Kraan Peter M; van den Berg Wim B
Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):507-14.
2002: Bakker A C; van de Loo F A J; Joosten L A B; Arntz O J; Varley A W; Munford R S; van den Berg W B
C3-Tat/HIV-regulated intraarticular human interleukin-1 receptor antagonist gene therapy results in efficient inhibition of collagen-induced arthritis superior to cytomegalovirus-regulated expression of the same transgene.
Arthritis and rheumatism 2002;46(6):1661-70.
2002: Joosten Leo A B; Heuvelmans-Jacobs Marleen; Lubberts Erik; van de Loo Fons A J; Bakker Andrew C; Helsen Monique M A; Richards Carl D; van den Berg Wim B
Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis.
Arthritis and rheumatism 2002;46(5):1379-89.
2002: van Lent P L E M; Holthuysen A E M; Slöetjes A; Lubberts E; van den Berg W B
Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(3):234-43.
2002: van de Loo Fons A J; van den Berg Wim B
Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators.
Rheumatic diseases clinics of North America 2002;28(1):127-49.
2001: Bakker A C; Van de Loo F A; Joosten L A; Bennink M B; Arntz O J; Dmitriev I P; Kashentsera E A; Curiel D T; van den Berg W B
A tropism-modified adenoviral vector increased the effectiveness of gene therapy for arthritis.
Gene therapy 2001;8(23):1785-93.
2001: Plater-Zyberk C; Joosten L A; Helsen M M; Sattonnet-Roche P; Siegfried C; Alouani S; van De Loo F A; Graber P; Aloni S; Cirillo R; Lubberts E; Dinarello C A; van Den Berg W B; Chvatchko Y
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis.
The Journal of clinical investigation 2001;108(12):1825-32.
2001: van Lent P L; Nabbe K; Blom A B; Holthuysen A E; Sloetjes A; van de Putte L B; Verbeek S; van den Berg W B
Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis.
The American journal of pathology 2001;159(6):2309-20.
2001: van Lent P L; Licht R; Dijkman H; Holthuysen A E; Berden J H; van den Berg W B
Uptake of apoptotic leukocytes by synovial lining macrophages inhibits immune complex-mediated arthritis.
Journal of leukocyte biology 2001;70(5):708-14.
2001: van den Berg W B; van der Kraan P M; Scharstuhl A; van Beuningen H M
Growth factors and cartilage repair.
Clinical orthopaedics and related research 2001;(391 Suppl):S244-50.
2001: van den Berg W B
Lessons from animal models of osteoarthritis.
Current opinion in rheumatology 2001;13(5):452-6.
2001: Netea M G; Kullberg B J; Joosten L A; Sprong T; Verschueren I; Boerman O C; Amiot F; van den Berg W B; Van der Meer J W
Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways.
European journal of immunology 2001;31(9):2529-38.
2001: van Susante JLC; Pieper J; Buma P; van Kuppevelt T H; van Beuningen H; van Der Kraan P M; Veerkamp J H; van den Berg W B; Veth RPH
Linkage of chondroitin-sulfate to type I collagen scaffolds stimulates the bioactivity of seeded chondrocytes in vitro.
Biomaterials 2001;22(17):2359-69.
2001: Lubberts E; Joosten L A; Oppers B; van den Bersselaar L; Coenen-de Roo C J; Kolls J K; Schwarzenberger P; van de Loo F A; van den Berg W B
IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):1004-13.
2001: Barrera P; Joosten L A; den Broeder A A; van de Putte L B; van Riel P L; van den Berg W B
Effects of treatment with a fully human anti-tumour necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFalpha in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2001;60(7):660-9.
2001: Stoop R; Buma P; van der Kraan P M; Hollander A P; Billinghurst R C; Meijers T H; Poole A R; van den Berg W B
Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(4):308-15.
2001: Bakker A C; van de Loo F A; van Beuningen H M; Sime P; van Lent P L; van der Kraan P M; Richards C D; van den Berg W B
Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):128-36.
2001: van der Kraan P M; Stoop R; Meijers T H; Poole A R; van den Berg W B
Expression of type X collagen in young and old C57Bl/6 and Balb/c mice. Relation with articular cartilage degeneration.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(2):92-100.
2001: Chabaud M; Lubberts E; Joosten L; van Den Berg W; Miossec P
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis.
Arthritis research 2001;3(3):168-77.
2001: van den Berg W B
Anti-cytokine therapy in chronic destructive arthritis.
Arthritis research 2001;3(1):18-26.
2000: de Hooge A S; van De Loo F A; Arntz O J; van Den Berg W B
Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis.
The American journal of pathology 2000;157(6):2081-91.
2000: Joosten L A; van De Loo F A; Lubberts E; Helsen M M; Netea M G; van Der Meer J W; Dinarello C A; van Den Berg W B
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6553-8.
2000: van den Berg W B
Arguments for interleukin 1 as a target in chronic arthritis.
Annals of the rheumatic diseases 2000;59 Suppl 1():i81-4.
2000: van den Berg W B; Joosten L A; Lubberts E; van de Loo F A; van Lent P L
Cytokine directed targeting in chronic arthritis.
European cytokine network 2000;11(3):481-2.
2000: Stoop R; Buma P; van der Kraan P M; Hollander A P; Clark Billinghurst R; Robin Poole A; van den Berg W B
Differences in type II collagen degradation between peripheral and central cartilage of rat stifle joints after cranial cruciate ligament transection.
Arthritis and rheumatism 2000;43(9):2121-31.
2000: Barrera P; Blom A; van Lent P L; van Bloois L; Beijnen J H; van Rooijen N; de Waal Malefijt M C; van de Putte L B; Storm G; van den Berg W B
Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(9):1951-9.
2000: Lubberts E; Joosten L A; Chabaud M; van Den Bersselaar L; Oppers B; Coenen-De Roo C J; Richards C D; Miossec P; van Den Berg W B
IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion.
The Journal of clinical investigation 2000;105(12):1697-710.
2000: Lubberts E; Joosten L A; van de Loo F A; van den Gersselaar L A; van den Berg W B
Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4.
Arthritis and rheumatism 2000;43(6):1300-6.
2000: Lubberts E; Joosten L A; Van Den Bersselaar L; Helsen M M; Bakker A C; Xing Z; Richards C D; Van Den Berg W B
Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw.
Clinical and experimental immunology 2000;120(2):375-83.
2000: van Lent P L; van Vuuren A J; Blom A B; Holthuysen A E; van de Putte L B; van de Winkel J G; van den Berg W B
Role of Fc receptor gamma chain in inflammation and cartilage damage during experimental antigen-induced arthritis.
Arthritis and rheumatism 2000;43(4):740-52.
2000: van der Kraan P M; Vitters E L; van Beuningen H M; van de Loo F A; van den Berg W B
Role of nitric oxide in the inhibition of BMP-2-mediated stimulation of proteoglycan synthesis in articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(2):82-6.
2000: Joosten L A; Coenen-de Roo C J; Helsen M M; Lubberts E; Boots A M; van den Berg W B; Miltenburg A M
Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/1 mice: amelioration of clinical, histologic, and radiologic signs of type II collagen-induced arthritis.
Arthritis and rheumatism 2000;43(3):645-55.
2000: Joosten L A; Helsen M M; van Den Berg W B
Blockade of endogenous interleukin 12 results in suppression of murine streptococcal cell wall arthritis by enhancement of interleukin 10 and interleukin 1Ra.
Annals of the rheumatic diseases 2000;59(3):196-205.
2000: van Susante J L; Buma P; van Beuningen H M; van den Berg W B; Veth R P
Responsiveness of bovine chondrocytes to growth factors in medium with different serum concentrations.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(1):68-77.
2000: van Beuningen H M; Glansbeek H L; van der Kraan P M; van den Berg W B
Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(1):25-33.
2000: Blom A B; van Lent P L; van Vuuren H; Holthuysen A E; Jacobs C; van de Putte L B; van de Winkel J G; van den Berg W B
Fc gamma R expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA).
Arthritis research 2000;2(6):489-503.
1999: Blom A B; van Lent P L; Holthuysen A E; van den Berg W B
Immune complexes, but not streptococcal cell walls or zymosan, cause chronic arthritis in mouse strains susceptible for collagen type II auto-immune arthritis.
Cytokine 1999;11(12):1046-56.
1999: van den Berg W B; Joosten L A; Kollias G; van De Loo F A
Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction.
Annals of the rheumatic diseases 1999;58 Suppl 1():I40-8.
1999: Stoop R; van der Kraan P M; Buma P; Hollander A P; Billinghurst R C; Poole A R; van den Berg W B
Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice.
Arthritis and rheumatism 1999;42(11):2381-9.
1999: van Meurs J; van Lent P; Holthuysen A; Lambrou D; Bayne E; Singer I; van den Berg W
Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5633-9.
1999: Joosten L A; Helsen M M; Saxne T; van De Loo F A; Heinegard D; van Den Berg W B
IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):5049-55.
1999: van Meurs J; van Lent P; Stoop R; Holthuysen A; Singer I; Bayne E; Mudgett J; Poole R; Billinghurst C; van der Kraan P; Buma P; van den Berg W
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity.
Arthritis and rheumatism 1999;42(10):2074-84.
1999: Lubberts E; Joosten L A; van Den Bersselaar L; Helsen M M; Bakker A C; van Meurs J B; Graham F L; Richards C D; van Den Berg W B
Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4546-56.
1999: van den Berg W B; van de Loo F; Joosten L A; Arntz O J
Animal models of arthritis in NOS2-deficient mice.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(4):413-5.
1999: Stoop R; van der Kraan P M; Buma P; Hollander A P; Poole A R; van den Berg W B
Denaturation of type II collagen in articular cartilage in experimental murine arthritis. Evidence for collagen degradation in both reversible and irreversible cartilage damage.
The Journal of pathology 1999;188(3):329-37.
1999: van Susante J L; Buma P; Schuman L; Homminga G N; van den Berg W B; Veth R P
Resurfacing potential of heterologous chondrocytes suspended in fibrin glue in large full-thickness defects of femoral articular cartilage: an experimental study in the goat.
Biomaterials 1999;20(13):1167-75.
1999: van Meurs J B; van Lent P L; Holthuysen A E; Singer I I; Bayne E K; van den Berg W B
Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.
Arthritis and rheumatism 1999;42(6):1128-39.
1999: van Meurs J B; van Lent P L; van de Loo A A; Holthuysen A E; Bayne E K; Singer I I; van den Berg W B
Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis.
Annals of the rheumatic diseases 1999;58(6):350-6.
1999: Joosten L A; Helsen M M; Saxne T; Heinegård D; van de Putte L B; van den Berg W B
Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(1):48-55.
1999: Joosten L A; Lubberts E; Helsen M M; Saxne T; Coenen-de Roo C J; Heinegård D; van den Berg W B
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis.
Arthritis research 1999;1(1):81-91.
1998: van Susante J L; Buma P; Homminga G N; van den Berg W B; Veth R P
Chondrocyte-seeded hydroxyapatite for repair of large articular cartilage defects. A pilot study in the goat.
Biomaterials 1998;19(24):2367-74.
1998: van der Kraan P M; Vitters E L; Meijers T H; Poole A R; van den Berg W B
Collagen type I antisense and collagen type IIA messenger RNA is expressed in adult murine articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(6):417-26.
1998: van Beuningen H M; Glansbeek H L; van der Kraan P M; van den Berg W B
Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(5):306-17.
1998: Kuiper S; Joosten L A; Bendele A M; Edwards C K; Arntz O J; Helsen M M; Van de Loo F A; Van den Berg W B
Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis.
Cytokine 1998;10(9):690-702.
1998: Van Lent P L; Holthuysen A E; Van Rooijen N; Van De Putte L B; Van Den Berg W B
Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis.
Annals of the rheumatic diseases 1998;57(7):408-13.
1998: van Lent P L; Holthuysen A E; van Rooijen N; van de Loo F A; van de Putte L B; van den Berg W B
Phagocytic synovial lining cells regulate acute and chronic joint inflammation after antigenic exacerbation of smouldering experimental murine arthritis.
The Journal of rheumatology 1998;25(6):1135-45.
1998: van Osch G J; van den Berg W B; Hunziker E B; Häuselmann H J
Differential effects of IGF-1 and TGF beta-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(3):187-95.
1998: Lubberts E; Joosten L A; Helsen M M; van den Berg W B
Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone.
Cytokine 1998;10(5):361-9.
1998: van Meurs J B; van Lent P L; Singer I I; Bayne E K; van de Loo F A; van den Berg W B
Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis.
Arthritis and rheumatism 1998;41(4):647-56.
1998: van de Loo F A; Arntz O J; van Enckevort F H; van Lent P L; van den Berg W B
Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation.
Arthritis and rheumatism 1998;41(4):634-46.
1998: Glansbeek H L; van Beuningen H M; Vitters E L; van der Kraan P M; van den Berg W B
Expression of recombinant human soluble type II transforming growth factor-beta receptor in Pichia pastoris and Escherichia coli: two powerful systems to express a potent inhibitor of transforming growth factor-beta.
Protein expression and purification 1998;12(2):201-7.
1998: Glansbeek H L; van Beuningen H M; Vitters E L; van der Kraan P M; van den Berg W B
Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints.
Laboratory investigation; a journal of technical methods and pathology 1998;78(2):133-42.
1997: Miossec P; van den Berg W
Th1/Th2 cytokine balance in arthritis.
Arthritis and rheumatism 1997;40(12):2105-15.
1997: Joosten L A; Lubberts E; Helsen M M; van den Berg W B
Dual role of IL-12 in early and late stages of murine collagen type II arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):4094-102.
1997: Van de Loo F A; Arntz O J; Van den Berg W B
Effect of interleukin 1 and leukaemia inhibitory factor on chondrocyte metabolism in articular cartilage from normal and interleukin-6-deficient mice: role of nitric oxide and IL-6 in the suppression of proteoglycan synthesis.
Cytokine 1997;9(7):453-62.
1997: van de Loo F A; Kuiper S; van Enckevort F H; Arntz O J; van den Berg W B
Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice.
The American journal of pathology 1997;151(1):177-91.
1997: Glansbeek H L; van Beuningen H M; Vitters E L; Morris E A; van der Kraan P M; van den Berg W B
Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content.
Arthritis and rheumatism 1997;40(6):1020-8.
1997: van den Berg W B
Lessons for joint destruction from animal models.
Current opinion in rheumatology 1997;9(3):221-8.
1997: Glansbeek H L; van der Kraan P M; Lafeber F P; Vitters E L; van den Berg W B
Species-specific expression of type II TGF-beta receptor isoforms by articular chondrocytes: effect of proteoglycan depletion and aging.
Cytokine 1997;9(5):347-51.
1997: Verschure P J; Van Marle J; Van Noorden C J; Van den Berg W B
The contribution of quantitative confocal laser scanning microscopy in cartilage research: chondrocyte insulin-like growth factor-1 receptors in health and pathology.
Microscopy research and technique 1997;37(4):285-98.
1997: Bakker A C; Joosten L A; Arntz O J; Helsen M M; Bendele A M; van de Loo F A; van den Berg W B
Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee.
Arthritis and rheumatism 1997;40(5):893-900.
1997: Van Lent P L; Blom A; Holthuysen A E; Jacobs C W; Van De Putte L B; Van Den Berg W B
Monocytes/macrophages rather than PMN are involved in early cartilage degradation in cationic immune complex arthritis in mice.
Journal of leukocyte biology 1997;61(3):267-78.
1997: van der Kraan P M; Glansbeek H L; Vitters E L; van den Berg W B
Early elevation of transforming growth factor-beta, decorin, and biglycan mRNA levels during cartilage matrix restoration after mild proteoglycan depletion.
The Journal of rheumatology 1997;24(3):543-9.
1997: Joosten L A; Lubberts E; Durez P; Helsen M M; Jacobs M J; Goldman M; van den Berg W B
Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction.
Arthritis and rheumatism 1997;40(2):249-60.
1997: Van Meurs J B; Van Lent P L; Joosten L A; Van der Kraan P M; Van den Berg W B
Quantification of mRNA levels in joint capsule and articular cartilage of the murine knee joint by RT-PCR: kinetics of stromelysin and IL-1 mRNA levels during arthritis.
Rheumatology international 1997;16(5):197-205.
1996: Verschure P J; Van Noorden C J; Van Marle J; Van den Berg W B
Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chondrocytes.
The Histochemical journal 1996;28(12):835-57.
1996: van den Berg W B; van Lent P L
The role of macrophages in chronic arthritis.
Immunobiology 1996;195(4-5):614-23.
1996: van Lent P L; Holthuysen A E; van den Bersselaar L A; van Rooijen N; Joosten L A; van de Loo F A; van de Putte L B; van den Berg W B
Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis.
Arthritis and rheumatism 1996;39(9):1545-55.
1996: van Osch G J; van der Kraan P M; Blankevoort L; Huiskes R; van den Berg W B
Relation of ligament damage with site specific cartilage loss and osteophyte formation in collagenase induced osteoarthritis in mice.
The Journal of rheumatology 1996;23(7):1227-32.
1996: Joosten L A; Helsen M M; van de Loo F A; van den Berg W B
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra.
Arthritis and rheumatism 1996;39(5):797-809.
1996: Verschure P J; Van Marle J; Joosten L A; Van Den Berg W B
Histochemical analysis of insulin-like growth factor-1 binding sites in mouse normal and experimentally induced arthritic articular cartilage.
The Histochemical journal 1996;28(1):13-23.
1996: van Osch G J; van der Kraan P M; van Valburg A A; van den Berg W B
The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee.
Rheumatology international 1996;16(3):115-9.
1996: van Valburg A A; van Osch G J; van der Kraan P M; van den Berg W B
Quantification of morphometric changes in murine experimental osteoarthritis using image analysis.
Rheumatology international 1996;15(5):181-7.
1995: Van Lent P L; Van De Loo F A; Holthuysen A E; Van Den Bersselaar L A; Vermeer H; Van Den Berg W B
Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice.
The Journal of rheumatology 1995;22(12):2250-8.
1995: Verschure P J; Joosten L A; Van de Loo F A; Van den Berg W B
IL-1 has no direct role in the IGF-1 non-responsive state during experimentally induced arthritis in mouse knee joints.
Annals of the rheumatic diseases 1995;54(12):976-82.
1995: van Osch G J; Blankevoort L; van der Kraan P M; Janssen B; Hekman E; Huiskes R; van den Berg W B
Laxity characteristics of normal and pathological murine knee joints in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1995;13(5):783-91.
1995: Verschure P J; van Marle J; Joosten L A; van den Berg W B
Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally induced arthritis.
Annals of the rheumatic diseases 1995;54(8):645-53.
1995: Schuman L; Buma P; Versleyen D; de Man B; van der Kraan P M; van den Berg W B; Homminga G N
Chondrocyte behaviour within different types of collagen gel in vitro.
Biomaterials 1995;16(10):809-14.
1995: van de Loo F A; Joosten L A; van Lent P L; Arntz O J; van den Berg W B
Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis.
Arthritis and rheumatism 1995;38(2):164-72.
1995: van den Berg W B
Growth factors in experimental osteoarthritis: transforming growth factor beta pathogenic?
The Journal of rheumatology. Supplement 1995;43():143-5.
1995: van de Loo A A; Arntz O J; Bakker A C; van Lent P L; Jacobs M J; van den Berg W B
Role of interleukin 1 in antigen-induced exacerbations of murine arthritis.
The American journal of pathology 1995;146(1):239-49.
1995: van Lent P L; Holthuysen A E; van den Bersselaar L; van Rooijen N; van de Putte L B; van den Berg W B
Role of macrophage-like synovial lining cells in localization and expression of experimental arthritis.
Scandinavian journal of rheumatology. Supplement 1995;101():83-9.
1995: van den Berg W B
Articular cartilage: cause or victim in arthritis.
Scandinavian journal of rheumatology. Supplement 1995;101():31-7.
1994: Kool J; De Visser H; Gerrits-Boeye M Y; Klasen I S; Melief M J; Van Helden-Meeuwsen C G; Van Lieshout L M; Ruseler-Van Embden J G; Van den Berg W B; Bahr G M
Detection of intestinal flora-derived bacterial antigen complexes in splenic macrophages of rats.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(11):1435-41.
1994: Jacobs M J; van den Hoek A E; van Lent P L; van de Loo F A; van de Putte L B; van den Berg W B
Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis.
Immunology 1994;83(3):390-6.
1994: van de Langerijt A G; Huitinga I; Joosten L A; Dijkstra C D; Van Lent P L; van den Berg W B
Role of beta 2 integrins in the recruitment of phagocytic cells in joint inflammation in the rat.
Clinical immunology and immunopathology 1994;73(1):123-31.
1994: van der Kraan P M; de Lange J; Vitters E L; van Beuningen H M; van Osch G J; van Lent P L; van den Berg W B
Analysis of changes in proteoglycan content in murine articular cartilage using image analysis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1994;2(3):207-14.
1994: van Beuningen H M; van der Kraan P M; Arntz O J; van den Berg W B
In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences.
Annals of the rheumatic diseases 1994;53(9):593-600.
1994: van Beuningen H M; van der Kraan P M; Arntz O J; van den Berg W B
Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint.
Laboratory investigation; a journal of technical methods and pathology 1994;71(2):279-90.
1994: Joosten L A; Helsen M M; van den Berg W B
Accelerated onset of collagen-induced arthritis by remote inflammation.
Clinical and experimental immunology 1994;97(2):204-11.
1994: van de Langerijt A G; van Lent P L; Hermus A R; Sweep C G; Cools A R; van den Berg W B
Susceptibility to adjuvant arthritis: relative importance of adrenal activity and bacterial flora.
Clinical and experimental immunology 1994;97(1):33-8.
1994: Verschure P J; Joosten L A; van der Kraan P M; Van den Berg W B
Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors.
Annals of the rheumatic diseases 1994;53(7):455-60.
1994: Verschure P J; van Marle J; Joosten L A; Van den Berg W B
Localization and quantification of the insulin-like growth factor-1 receptor in mouse articular cartilage by confocal laser scanning microscopy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(6):765-73.
1994: van Osch G J; van der Kraan P M; van den Berg W B
Site specific inhibition of cartilage proteoglycan synthesis in the murine knee joint. Differences between 3 metabolic stimuli.
The Journal of rheumatology 1994;21(6):1107-12.
1994: Jacobs M J; van den Hoek A E; van de Putte L B; van den Berg W B
Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance.
Immunology 1994;82(2):294-300.
1994: van de Langerijt A G; Kingston A E; van Lent P L; Billingham M E; van den Berg W B
Cross-reactivity to proteoglycans in bacterial arthritis: lack of evidence for in vivo role in induction of disease.
Clinical immunology and immunopathology 1994;71(3):273-80.
1994: Verschure P J; van der Kraan P M; Vitters E L; van den Berg W B
Stimulation of proteoglycan synthesis by triamcinolone acetonide and insulin-like growth factor 1 in normal and arthritic murine articular cartilage.
The Journal of rheumatology 1994;21(5):920-6.
1994: van de Loo A A; Arntz O J; Otterness I G; van den Berg W B
Proteoglycan loss and subsequent replenishment in articular cartilage after a mild arthritic insult by IL-1 in mice: impaired proteoglycan turnover in the recovery phase.
Agents and actions 1994;41(3-4):200-8.
1994: Jacobs M J; van den Hoek A E; van de Putte L B; van den Berg W B
Suppression of hen egg lysozyme-induced arthritis by intravenous antigen administration: no role in this for antigen-driven bystander suppression.
Clinical and experimental immunology 1994;96(1):36-42.
1994: Van de Langerijt A G; Volsen S G; Hicks C A; Craig P J; Billingham M E; Van den Berg W B
Cell migration studies in the adoptive transfer of adjuvant arthritis in the Lewis rat.
Immunology 1994;81(3):414-9.
1994: van Osch G J; van der Kraan P M; van den Berg W B
Site-specific cartilage changes in murine degenerative knee joint disease induced by iodoacetate and collagenase.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(2):168-75.
1994: van den Berg W B; Joosten L A; Helsen M; van de Loo F A
Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment.
Clinical and experimental immunology 1994;95(2):237-43.
1994: van Lent P L; van den Hoek A E; van den Bersselaar L A; van de Loo F A; Eykholt H E; Brouwer W F; van de Putte L B; van den Berg W B
Early cartilage degradation in cationic immune complex arthritis in mice: relative role of interleukin 1, the polymorphonuclear cell (PMN) and PMN elastase.
The Journal of rheumatology 1994;21(2):321-9.
1993: Jacobs M J; van den Hoek A E; van de Putte L B; van den Berg W B
Induction of tolerance by T-cell vaccination is possible beyond the area of autoimmunity: down-regulation of immunity directed to foreign protein antigens.
Immunology 1993;80(4):511-7.
1993: van Beuningen H M; Arntz O J; van den Berg W B
Insulin-like growth factor stimulation of articular chondrocyte proteoglycan synthesis. Availability and responses at different ages.
British journal of rheumatology 1993;32(12):1037-43.
1993: Glansbeek H L; van der Kraan P M; Vitters E L; van den Berg W B
Correlation of the size of type II transforming growth factor beta (TGF-beta) receptor with TGF-beta responses of isolated bovine articular chondrocytes.
Annals of the rheumatic diseases 1993;52(11):812-6.
1993: van den Berg W B; van Osch G J; van der Kraan P M; van Beuningen H M
Cartilage destruction and osteophytes in instability-induced murine osteoarthritis: role of TGF beta in osteophyte formation?
Agents and actions 1993;40(3-4):215-9.
1993: van de Langerijt A G; van Lent P L; Hermus A R; van de Putte L B; van den Berg W B
Regulation of resistance against adjuvant arthritis in the Fisher rat.
Clinical and experimental immunology 1993;94(1):150-5.
1993: van den Hoogen F H; van der Kraan P M; Boerbooms A M; van den Berg W B; van Lier H J; van de Putte L B
Effects of methotrexate on glycosaminoglycan production by scleroderma fibroblasts in culture.
Annals of the rheumatic diseases 1993;52(10):758-61.
1993: van der Kraan P M; Vitters E L; Postma N S; Verbunt J; van den Berg W B
Maintenance of the synthesis of large proteoglycans in anatomically intact murine articular cartilage by steroids and insulin-like growth factor I.
Annals of the rheumatic diseases 1993;52(10):734-41.
1993: Van Lent P L; Van den Hoek A E; Van den Bersselaar L A; Spanjaards M F; Van Rooijen N; Dijkstra C D; Van de Putte L B; Van den Berg W B
In vivo role of phagocytic synovial lining cells in onset of experimental arthritis.
The American journal of pathology 1993;143(4):1226-37.
1993: Homminga G N; Buma P; Koot H W; van der Kraan P M; van den Berg W B
Chondrocyte behavior in fibrin glue in vitro.
Acta orthopaedica Scandinavica 1993;64(4):441-5.
1993: van Osch G J; van der Kraan P M; Vitters E L; Blankevoort L; van den Berg W B
Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1993;1(3):171-7.
1993: van Osch G J; van der Kraan P M; van den Berg W B
In vivo quantification of proteoglycan synthesis in articular cartilage of different topographical areas in the murine knee joint.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1993;11(4):492-9.
1993: van Beuningen H M; van der Kraan P M; Arntz O J; van den Berg W B
Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo.
Annals of the rheumatic diseases 1993;52(3):185-91.
1993: Jacobs M J; van den Hoek A E; van de Putte L B; van den Berg W B
Aberrant tolerance induction with cationic antigens.
Scandinavian journal of immunology 1993;37(1):97-103.
1993: van Lent P L; van den Bersselaar L; van den Hoek A E; van de Ende M; Dijkstra C D; van Rooijen N; van de Putte L B; van den Berg W B
Reversible depletion of synovial lining cells after intra-articular treatment with liposome-encapsulated dichloromethylene diphosphonate.
Rheumatology international 1993;13(1):21-30.
1993: van den Berg W B; van de Loo F A; van Lent P L; Joosten L A
Mechanisms of cartilage destruction in joint inflammation.
Agents and actions. Supplements 1993;39():49-60.
1993: van Beuningen H M; van der Kraan P M; Arntz O J; van den Berg W B
Does TGF-beta protect articular cartilage in vivo?
Agents and actions. Supplements 1993;39():127-31.
1993: Glansbeek H L; van der Kraan P M; Vitters E L; van den Berg W B
Variable TGF-beta receptor expression regulates TGF-beta responses of articular chondrocytes.
Agents and actions. Supplements 1993;39():139-45.
1993: van Lent P L; van den Hoek A E; van den Bersselaar L; van Rooijen N; van den Berg W B
Role of phagocytic synovial lining cells in experimental arthritis.
Agents and actions 1993;38 Spec No():C92-4.
1993: van de Loo F A; Arntz O J; Otterness I G; van den Berg W B
Modulation of cartilage destruction in murine arthritis with anti-IL-1 antibodies.
Agents and actions 1993;39 Spec No():C211-4.
1992: van den Broek M F; de Heer E; van Bruggen M C; de Roo G; Kleiverda K; Eulderink F; van den Berg W B
Immunomodulation of streptococcal cell wall-induced arthritis. Identification of inflammatory cells and regulatory T cell subsets by mercuric chloride and in vivo CD8 depletion.
European journal of immunology 1992;22(12):3091-5.
1992: van Lent P L; van den Bersselaar L A; van den Hoek A E; van de Loo A A; van den Berg W B
Cationic immune complex arthritis in mice--a new model. Synergistic effect of complement and interleukin-1.
The American journal of pathology 1992;140(6):1451-61.
1992: Lafeber F P; van der Kraan P M; van Roy H L; Vitters E L; Huber-Bruning O; van den Berg W B; Bijlsma J W
Local changes in proteoglycan synthesis during culture are different for normal and osteoarthritic cartilage.
The American journal of pathology 1992;140(6):1421-9.
1992: van der Kraan P M; Vitters E L; van Beuningen H M; van den Berg W B
Proteoglycan synthesis and osteophyte formation in 'metabolically' and 'mechanically' induced murine degenerative joint disease: an in-vivo autoradiographic study.
International journal of experimental pathology 1992;73(3):335-50.
1992: van der Kraan P M; Vitters E L; van den Berg W B
Inhibition of proteoglycan synthesis by transforming growth factor beta in anatomically intact articular cartilage of murine patellae.
Annals of the rheumatic diseases 1992;51(5):643-7.
1992: van den Broek M F; van Bruggen M C; Koopman J P; Hazenberg M P; van den Berg W B
Gut flora induces and maintains resistance against streptococcal cell wall-induced arthritis in F344 rats.
Clinical and experimental immunology 1992;88(2):313-7.
1992: van de Loo F A; Arntz O J; Otterness I G; van den Berg W B
Protection against cartilage proteoglycan synthesis inhibition by antiinterleukin 1 antibodies in experimental arthritis.
The Journal of rheumatology 1992;19(3):348-56.
1992: van de Loo A A; Arntz O J; van den Berg W B
Flare-up of experimental arthritis in mice with murine recombinant IL-1.
Clinical and experimental immunology 1992;87(2):196-202.
1992: Klasen I S; Kool J; Melief M J; Loeve I; van den Berg W B; Severijnen A J; Hazenberg M P
Arthritis by autoreactive T cell lines obtained from rats after injection of intestinal bacterial cell wall fragments.
Cellular immunology 1992;139(2):455-67.
1992: Van Lent P L; Van den Hoek A; Van den Bersselaar L; Dijkstra C D; Van Rooijen N; Van den Berg W B
Role of synovial macrophages in experimental arthritis.
Research in immunology 1992;143(2):229-34.
1992: Van den Broek M F; Van de Langerijt L G; Van Bruggen M C; Billingham M E; Van den Berg W B
Treatment of rats with monoclonal anti-CD4 induces long-term resistance to streptococcal cell wall-induced arthritis.
European journal of immunology 1992;22(1):57-61.
1992: van der Kraan P; Vitters E; van den Berg W
Differential effect of transforming growth factor beta on freshly isolated and cultured articular chondrocytes.
The Journal of rheumatology 1992;19(1):140-5.
1991: Kool J; Ruseler-van Embden J G; van Lieshout L M; de Visser H; Gerrits-Boeye M Y; van den Berg W B; Hazenberg M P
Induction of arthritis in rats by soluble peptidoglycan-polysaccharide complexes produced by human intestinal flora.
Arthritis and rheumatism 1991;34(12):1611-6.
1991: van Bruggen M C; van den Broek M F; van den Berg W B
Streptococcal cell wall-induced arthritis and adjuvant arthritis in F344----Lewis and in Lewis----F344 bone marrow chimeras.
Cellular immunology 1991;136(2):278-90.
1991: van Beuningen H M; Arntz O J; van den Berg W B
In vivo effects of interleukin-1 on articular cartilage. Prolongation of proteoglycan metabolic disturbances in old mice.
Arthritis and rheumatism 1991;34(5):606-15.
1991: van Lent P L; van de Loo F A; van den Bersselaar L; van den Berg W B
Chondrocyte nonresponsiveness of arthritic articular cartilage caused by short term immobilization.
The Journal of rheumatology 1991;18(5):709-15.
1991: Joosten L A; Helsen M M; van den Berg W B
Transient chondrocyte nonresponsiveness to insulin-like growth factor-1 upon H2O2 exposure is not related to IGF receptor damage.
The Journal of rheumatology 1991;18(4):585-90.
1991: Grandia A A; de Visser H; van Embden J D; van der Zee R; van den Berg W B; Hazenberg M P
Natural antibodies to 65 kD mycobacterial heat shock protein in rats do not correlate with susceptibility for Mycobacterium tuberculosis induced adjuvant arthritis.
Immunobiology 1991;182(2):127-34.
1991: van den Berg W B
Impact of NSAID and steroids on cartilage destruction in murine antigen induced arthritis.
The Journal of rheumatology. Supplement 1991;27():122-3.
1991: van Lent P L; Joosten L A; van den Bersselaar L; van den Berg W B
Role of PMN in early cartilage destruction.
Agents and actions 1991;32(1-2):94-5.
1991: van den Berg W B; van de Loo F A; Otterness I; Arntz O; Joosten L A
In vivo evidence for a key role of IL-1 in cartilage destruction in experimental arthritis.
Agents and actions. Supplements 1991;32():159-63.
1990: Joosten L A; Helsen M M; van den Berg W B
Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonide.
Agents and actions 1990;31(1-2):135-42.
1990: Schalkwijk J; Joosten L A; van den Berg W B; van de Putte L B
Antigen induced arthritis in beige (Chediak-Higashi) mice.
Annals of the rheumatic diseases 1990;49(8):607-10.
1990: van der Kraan P M; Vitters E L; de Vries B J; van den Berg W B
High susceptibility of human articular cartilage glycosaminoglycan synthesis to changes in inorganic sulfate availability.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1990;8(4):565-71.
1990: van Lent P L; van den Bersselaar L; van de Putte L B; van den Berg W B
Immobilization aggravates cartilage damage during antigen-induced arthritis in mice. Attachment of polymorphonuclear leukocytes to articular cartilage.
The American journal of pathology 1990;136(6):1407-16.
1990: van de Loo A A; van den Berg W B
Effects of murine recombinant interleukin 1 on synovial joints in mice: measurement of patellar cartilage metabolism and joint inflammation.
Annals of the rheumatic diseases 1990;49(4):238-45.
1990: van der Kraan P M; Vitters E L; de Vries B J; van den Berg W B; van de Putte L B
The effect of chronic paracetamol administration to rats on the glycosaminoglycan content of patellar cartilage.
Agents and actions 1990;29(3-4):218-23.
1990: de Vries B J; van den Berg W B
Impact of NSAIDS on murine antigen induced arthritis. II. A light microscopic investigation of antiinflammatory and bone protective effects.
The Journal of rheumatology 1990;17(3):295-303.
1990: de Vries B J; van der Kraan P M; van den Berg W B
Decrease of inorganic blood sulfate following treatment with selected antirheumatic drugs: potential consequence for articular cartilage.
Agents and actions 1990;29(3-4):224-31.
1990: van den Broek M F; van Bruggen M C; Stimpson S A; Severijnen A J; van de Putte L B; van den Berg W B
Flare-up reaction of streptococcal cell wall induced arthritis in Lewis and F344 rats: the role of T lymphocytes.
Clinical and experimental immunology 1990;79(2):297-306.
1990: van der Kraan P M; Vitters E L; van Beuningen H M; van de Putte L B; van den Berg W B
Degenerative knee joint lesions in mice after a single intra-articular collagenase injection. A new model of osteoarthritis.
Journal of experimental pathology (Oxford, England) 1990;71(1):19-31.
1990: van Lent P L; van den Bersselaar L; van den Berg W B
Allergic arthritis induced by cationic proteins.
Agents and actions 1990;29(1-2):98-9.
1990: Joosten L A; Helsen M M; van den Berg W B
Inflammation-mediated chondrocyte unresponsiveness to insulin-like growth factor-1 is not caused by H2O2.
Agents and actions 1990;29(1-2):100-2.
1989: Faaber P; van den Bersselaar L A; van de Putte L B; van den Berg W B
Immune complex formation between IgM rheumatoid factor and IgG generated by hyaluronic acid.
Arthritis and rheumatism 1989;32(12):1521-7.
1989: van der Kraan P M; Vitters E L; van de Putte L B; van den Berg W B
Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints.
The American journal of pathology 1989;135(6):1001-14.
1989: van Lent P L; Wilms F H; van den Berg W B
Interaction of polymorphonuclear leucocytes with patellar cartilage of immobilised arthritic joints: a scanning electron microscopic study.
Annals of the rheumatic diseases 1989;48(10):832-7.
1989: van Lent P L; van den Bersselaar L; Grutters G J; van den Berg W B
Fate of antigen after intravenous and intraarticular injection into mice. Role of molecular weight and charge.
The Journal of rheumatology 1989;16(10):1295-303.
1989: Faaber P; van den Bersselaar L A; van de Putte L; van den Berg W B
Circulating immune complexes and rheumatoid arthritis: the induction of immune complex formation between rheumatoid factor and IgG by polyethylene glycol.
The Journal of rheumatology 1989;16(10):1304-9.
1989: de Vries B J; van den Berg W B
Impact of NSAIDS on murine antigen induced arthritis. I. Investigation of antiinflammatory and chondroprotective effects.
The Journal of rheumatology. Supplement 1989;18():10-8.
1989: van den Broek M F; Hogervorst E J; Van Bruggen M C; Van Eden W; van der Zee R; van den Berg W B
Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein.
The Journal of experimental medicine 1989;170(2):449-66.
1989: van Lent P L; Dekker C; Mosterd J; van den Bersselaar L; van den Berg W B
Allergic arthritis induced by cationic proteins: role of molecular weight.
Immunology 1989;67(4):447-52.
1989: Schalkwijk J; Joosten L A; van den Berg W B; van de Putte L B
Chondrocyte nonresponsiveness to insulin-like growth factor 1 in experimental arthritis.
Arthritis and rheumatism 1989;32(7):894-900.
1989: van Beuningen H M; van den Berg W B; Schalkwijk J; Arntz O J; van de Putte L B
Age- and sex-related differences in antigen-induced arthritis in C57Bl/10 mice.
Arthritis and rheumatism 1989;32(6):789-94.
1989: Klasen I S; Ladestein R M; van den Berg W B; Benner R
Requirements for flare reactions of joint inflammation induced in mice by cloned MT4+, Lyt-2- T cells.
Arthritis and rheumatism 1989;32(3):330-7.
1989: Schalkwijk J; Joosten L A; van den Berg W B; van Wyk J J; van de Putte L B
Insulin-like growth factor stimulation of chondrocyte proteoglycan synthesis by human synovial fluid.
Arthritis and rheumatism 1989;32(1):66-71.
1989: van Lent P L; van de Loo A A; van den Bersselaar L; van den Berg W B
Short-term immobilization restores and prevents inhibition of chondrocyte synthesis caused by IL-1.
Agents and actions 1989;26(1-2):191-2.
1989: van de Loo A A; van Beuningen H M; van Lent P L; van den Berg W B
Direct effect of murine rIL-1 on cartilage metabolism in vivo.
Agents and actions 1989;26(1-2):153-5.
1989: Joosten L A; Schalkwijk J; van den Berg W B; van de Putte L B
Chondrocyte unresponsiveness to insulin-like growth factor-1. A novel pathogenetic mechanisms for cartilage destruction in experimental arthritis.
Agents and actions 1989;26(1-2):193-5.
1989: Raghoebar M; Tiemessen H L; van den Berg W B; van Ginneken C A
Modes of association of indometacin with human polymorphonuclear leucocytes.
Pharmacology 1989;39(6):350-61.
1989: van der Kraan P M; de Vries B J; Vitters E L; van den Berg W B; van de Putte L B
The effect of low sulfate concentrations on the glycosaminoglycan synthesis in anatomically intact articular cartilage of the mouse.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1989;7(5):645-53.
1989: Raghoebar M; Van den Berg W B; Van Ginneken C A
The polymorphonuclear leukocyte: its pharmacological transport and target properties: an overview.
Drug metabolism and drug interactions 1989;7(4):351-401.
1988: Schalkwijk J; Joosten L A; van den Berg W B; van de Putte L B
Experimental arthritis in C57black/6 normal and beige (Chediak-Higashi) mice: in vivo and in vitro observations on cartilage degradation.
Annals of the rheumatic diseases 1988;47(11):940-6.
1988: van den Berg W B; van de Loo F A; Zwarts W A; Otterness I G
Effects of murine recombinant interleukin 1 on intact homologous articular cartilage: a quantitative and autoradiographic study.
Annals of the rheumatic diseases 1988;47(10):855-63.
1988: van den Broek M F; van Bruggen M C; van de Putte L B; van den Berg W B
T cell responses to streptococcal antigens in rats: relation to susceptibility to streptococcal cell wall-induced arthritis.
Cellular immunology 1988;116(1):216-29.
1988: van der Kraan P M; de Vries B J; Vitters E L; van den Berg W B; van de Putte L B
Inhibition of glycosaminoglycan synthesis in anatomically intact rat patellar cartilage by paracetamol-induced serum sulfate depletion.
Biochemical pharmacology 1988;37(19):3683-90.
1988: van den Broek M F; van den Berg W B; van de Putte L B; Severijnen A J
Streptococcal cell wall-induced arthritis and flare-up reaction in mice induced by homologous or heterologous cell walls.
The American journal of pathology 1988;133(1):139-49.
1988: Raghoebar M; Lindeyer E; Van den Berg W B; Van Ginneken C A
On the mechanisms of association of the macrolide antibiotic erythromycin with isolated human polymorphonuclear leucocytes.
Biochemical pharmacology 1988;37(17):3221-7.
1988: Van den Broek M F; Van de Putte L B; Van den Berg W B
Crohn's disease associated with arthritis: a possible role for cross-reactivity between gut bacteria and cartilage in the pathogenesis of arthritis.
Arthritis and rheumatism 1988;31(8):1077-9.
1988: Van den Elsen J H; Van den Broek M F; Klasen I S; Van den Berg W B
Stimulation of antigen-specific murine T cell clones in vitro with antigen-pulsed adherent cells fixed to a carrier.
Journal of immunological methods 1988;112(1):15-22.
1988: Raghoebar M; Huisman J A; van den Berg W B; van Riel P L; van Ginneken C A
Chloroquine interaction with inflammatory human polymorphonuclear leucocytes.
Agents and actions 1988;24(3-4):331-42.
1988: Raghoebar M; Van den Berg W B; Van Ginneken C A
Mechanisms of cell association of some non-steroidal anti-inflammatory drugs with isolated leucocytes.
Biochemical pharmacology 1988;37(7):1245-50.
1988: van den Broek M F; van den Berg W B; Arntz O J; van de Putte L B
Reaction of bacterium-primed murine T cells to cartilage components: a clue for the pathogenesis of arthritis?
Clinical and experimental immunology 1988;72(1):9-14.
1988: van den Broek M F; van den Berg W B; van de Putte L B
The role of mast cells in antigen induced arthritis in mice.
The Journal of rheumatology 1988;15(4):544-51.
1988: van der Kraan P M; Vitters E L; de Vries B J; van den Berg W B; van de Putte L B
Synthesis of aberrant glycosaminoglycans during cartilage culture in 'sulfate free' medium.
Journal of biochemical and biophysical methods 1988;15(5):273-7.
1988: van Beuningen H M; van den Berg W B; Schalkwijk J; Arntz O J; van de Putte L B
Age-related changes in joint damage caused by antigen-induced arthritis in mice.
Agents and actions 1988;23(1-2):74-6.
1988: van der Kraan P M; de Vries B J; van den Berg W B; Vitters E; van de Putte L B
Effects of drug-mediated serum sulfate depletion on glycosaminoglycan synthesis.
Agents and actions 1988;23(1-2):55-7.
1988: de Vries B J; van den Berg W B; Vitters E; van de Putte L B
The influence of antirheumatic drugs on basal and accelerated breakdown of articular proteoglycans.
Agents and actions 1988;23(1-2):52-4.
1988: Klasen I S; Ladestein R M; van den Berg W B; Benner R
Flare up of joint inflammations induced by cloned helper T cells. Retention of the helper T cells.
Agents and actions 1988;23(1-2):69-73.
1988: Schalkwijk J; Joosten L A; van den Berg W B; van de Putte L B
Degradation of cartilage proteoglycans by elastase is dependent on charge-mediated interactions.
Rheumatology international 1988;8(1):27-33.
1988: van den Berg W B
Influence of joint inflammation on chondrocyte function.
International journal of tissue reactions 1988;10(1):17-23.
1988: de Vries B J; van den Berg W B; Vitters E; van de Putte L B
Effect of nonsteroidal antiinflammatory drugs on cartilage destruction in antigen induced arthritis in mice.
Scandinavian journal of rheumatology. Supplement 1988;77():23-8.
1988: van Lent P L; van den Berg W B; van de Putte L B; van den Bersselaar L
Electrical charge of a protein determines penetration and localization in hyaline articular cartilage. Quantitative and autoradiographic studies on cartilage of different species, including man.
Rheumatology international 1988;8(4):145-52.
1987: Raghoebar M; van den Berg W B; Huisman J A; van Ginneken C A
The cellular association of sodium salicylate and indomethacin in peritoneal fluid of ascites bearing mice.
Agents and actions 1987;22(3-4):314-23.
1987: Raghoebar M; Huisman J A; Van den Berg W B; Van Ginneken C A
An in vitro approach to study cellular kinetics of drugs.
Journal of pharmacological methods 1987;18(3):239-51.
1987: Klasen I S; Ladestein R M; Donselaar I G; van den Berg W B; Tees R; Benner R
Joint inflammation in mice induced by a MT4+ Lyt-2- T cell clone. Characteristics and the induction of flare-up reactions.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3275-80.
1987: van Lent P L; van den Berg W B; Schalkwijk J; van de Putte L B; van den Bersselaar L
Allergic arthritis induced by cationic antigens: relationship of chronicity with antigen retention and T-cell reactivity.
Immunology 1987;62(2):265-72.
1987: van Lent P L; van den Berg W B; Schalkwijk J; van de Putte L B; van den Bersselaar L
The impact of protein size and charge on its retention in articular cartilage.
The Journal of rheumatology 1987;14(4):798-805.
1987: de Vries B J; Vitters E; van den Berg W B; Schram D; van de Putte L B
Determination of small quantities of sulfate (0-12 nmol) in serum, urine, and cartilage of the mouse.
Analytical biochemistry 1987;163(2):408-17.
1987: Raghoebar M; van den Berg W B; van Ginneken C A
Alteration of chloroquine accumulation in human polymorphonuclear leucocytes under inflammatory conditions.
International journal of tissue reactions 1987;9(3):255-61.
1986: Klasen I S; Donselaar I G; Ladestein R M; van den Berg W B; Benner R
Joint inflammations and flare-up reactions in mice induced by a helper T cell clone.
Agents and actions 1986;19(5-6):331-4.
1986: Raghoebar M; Peeters P A; van den Berg W B; van Ginneken C A
Mechanisms of cell association of chloroquine to leucocytes.
The Journal of pharmacology and experimental therapeutics 1986;238(1):302-6.
1984: Raghoebar M; Tiemessen H L; Peeters P A; van den Berg W B; van Ginneken C A; van der Putte L B
Association of sodium salicylate to isolated leucocytes.
Biochemical pharmacology 1984;33(18):2937-41.

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