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Marleen Van den Broeck

Research Profile

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Belgium

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Tim Van Langenhove; Rik Vandenberghe; Mathieu Vandenbulcke; Jan Versijpt; Christiana Willems; Marleen Van den Broeck; Julie van der Zee; Veerle Bäumer; Patrick cras; Marc Cruts; Jan De Bleecker; Peter P De Deyn; Peter De Jonghe; Olivier Deryck; Lubina Dillen; Sebastiaan Engelborghs; Ilse Gijselinck; Adrian Ivanoiu; Githa Maes; Jean-Jacques Martin; Maria Mattheijssens; Alex Michotte; Karin Peeters; Stéphanie Philtjens; Patrick Santens; Anne Sieben; Christine Van Broeckhoven
Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort.
Tim Van Langenhove; Rik Vandenberghe; Marleen Van den Broeck; Julie van der Zee; Patrick cras; Marc Cruts; Peter P De Deyn; Peter De Jonghe; Sebastiaan Engelborghs; Maria Mattheijssens; Dirk Nuytten; Karin Peeters; Patrick Santens; Christine Van Broeckhoven
Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts.
Bram Meeus; Karin Peeters; Barbara A Pickut; Ellen Corsmit; Patrick cras; David Crosiers; Peter Paul De Deyn; Ellen Elinck; Sebastiaan Engelborghs; Maria Mattheijssens; Christine Van Broeckhoven; Marleen Van den Broeck; Rik Vandenberghe; Aline Verstraeten; Jessie Theuns
DLB and PDD: a role for mutations in dementia and Parkinson disease genes?

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All Publications

2013: Tim Van Langenhove; Rik Vandenberghe; Mathieu Vandenbulcke; Jan Versijpt; Christiana Willems; Marleen Van den Broeck; Julie van der Zee; Veerle Bäumer; Patrick cras; Marc Cruts; Jan De Bleecker; Peter P De Deyn; Peter De Jonghe; Olivier Deryck; Lubina Dillen; Sebastiaan Engelborghs; Ilse Gijselinck; Adrian Ivanoiu; Githa Maes; Jean-Jacques Martin; Maria Mattheijssens; Alex Michotte; Karin Peeters; Stéphanie Philtjens; Patrick Santens; Anne Sieben; Christine Van Broeckhoven
Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort.
JAMA neurology 2013;70(3):365-73.
2012: Tim Van Langenhove; Rik Vandenberghe; Marleen Van den Broeck; Julie van der Zee; Patrick cras; Marc Cruts; Peter P De Deyn; Peter De Jonghe; Sebastiaan Engelborghs; Maria Mattheijssens; Dirk Nuytten; Karin Peeters; Patrick Santens; Christine Van Broeckhoven
Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts.
Neurobiology of aging 2012;33(5):1004.e17-20.
2012: Bram Meeus; Karin Peeters; Barbara A Pickut; Ellen Corsmit; Patrick cras; David Crosiers; Peter Paul De Deyn; Ellen Elinck; Sebastiaan Engelborghs; Maria Mattheijssens; Christine Van Broeckhoven; Marleen Van den Broeck; Rik Vandenberghe; Aline Verstraeten; Jessie Theuns
DLB and PDD: a role for mutations in dementia and Parkinson disease genes?
Neurobiology of aging 2012;33(3):629.e5-629.e18.
2011: Julie van der Zee; Tim Van Langenhove; Gernot Kleinberger; Kristel Sleegers; Sebastiaan Engelborghs; Rik Vandenberghe; Patrick Santens; Marleen Van den Broeck; Geert Joris; Jolien Brys; Maria Mattheijssens; Karin Peeters; Patrick Cras; Peter P De Deyn; Marc Cruts; Christine Van Broeckhoven
TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.
Brain : a journal of neurology 2011;134(Pt 3):808-15.
2010: Raf Brouns; Vincent Thijs; François Eyskens; Marleen Van den Broeck; Shibeshih Belachew; Christine Van Broeckhoven; Patricia Redondo; Dimitri Hemelsoet; Arnaud Fumal; Sandrine Jeangette; Werner Verslegers; Robert Baker; derralynn hughes; Peter Paul De Deyn
Belgian Fabry study: prevalence of Fabry disease in a cohort of 1000 young patients with cerebrovascular disease.
Stroke; a journal of cerebral circulation 2010;41(5):863-8.
2010: T Van Langenhove; Julie van der Zee; Kristel Sleegers; Sebastiaan Engelborghs; Rik Vandenberghe; Ilse Gijselinck; Marleen Van den Broeck; Maria Mattheijssens; Karin Peeters; Peter Paul De Deyn; Marc Cruts; Christine Van Broeckhoven
Genetic contribution of FUS to frontotemporal lobar degeneration.
Neurology 2010;74(5):366-71.
2009: Raf Brouns; C Ceuterick-de Groote; K De Boeck; F Eyskens; Christine Van Broeckhoven; Marleen Van den Broeck; P P De Deyn
Fabry disease in a patient with Turner syndrome.
Journal of inherited metabolic disease 2009;32 Suppl 1():S45-8.
2009: Julie van der Zee; Daniel Pirici; T Van Langenhove; Sebastiaan Engelborghs; Rik Vandenberghe; M Hoffmann; G Pusswald; Marleen Van den Broeck; Karin Peeters; Maria Mattheijssens; Jean-Jacques Martin; Peter Paul De Deyn; Marc Cruts; D Haubenberger; Samir Kumar-Singh; A Zimprich; Christine Van Broeckhoven
Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His.
Neurology 2009;73(8):626-32.
2009: Karen Nuytemans; Bram Meeus; David Crosiers; Nathalie Brouwers; Dirk Goossens; Sebastiaan Engelborghs; Philippe Pals; Barbara A Pickut; Marleen Van den Broeck; Ellen Corsmit; Patrick Cras; Peter P De Deyn; Jurgen Del-Favero; Christine Van Broeckhoven; Jessie Theuns
Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.
Human mutation 2009;30(7):1054-61.
2008: Nathalie Brouwers; Kristel Sleegers; Sebastiaan Engelborghs; Sebastian Maurer-Stroh; Ilse Gijselinck; Julie van der Zee; Barbara A Pickut; Marleen Van den Broeck; Maria Mattheijssens; Karin Peeters; J Schymkowitz; Frederic Rousseau; Jean-Jacques Martin; Marc Cruts; Peter Paul De Deyn; Christine Van Broeckhoven
Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
Neurology 2008;71(9):656-64.
2008: Kristel Sleegers; Nathalie Brouwers; Sebastian Maurer-Stroh; M A van Es; P Van Damme; P W J van Vught; Julie van der Zee; Sally Serneels; Tim De Pooter; Marleen Van den Broeck; Marc Cruts; J Schymkowitz; Peter De Jonghe; Frederic Rousseau; L H van den Berg; Wim Robberecht; Christine Van Broeckhoven
Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
Neurology 2008;71(4):253-9.
2008: Karen Nuytemans; Rosa Rademakers; Jessie Theuns; Philippe Pals; Sebastiaan Engelborghs; Barbara A Pickut; Tim De Pooter; Karin Peeters; Maria Mattheijssens; Marleen Van den Broeck; Patrick Cras; Peter Paul De Deyn; Christine Van Broeckhoven
Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients.
European journal of human genetics : EJHG 2008;16(4):471-9.
2007: Nathalie Brouwers; Karen Nuytemans; Julie van der Zee; Ilse Gijselinck; Sebastiaan Engelborghs; Jessie Theuns; Samir Kumar-Singh; Barbara A Pickut; Philippe Pals; Bart Dermaut; Veerle Bogaerts; Tim De Pooter; Sally Serneels; Marleen Van den Broeck; Ivy Cuijt; Maria Mattheijssens; Karin Peeters; Raf Sciot; Jean-Jacques Martin; Patrick Cras; Patrick Santens; Rik Vandenberghe; Peter Paul De Deyn; Marc Cruts; Christine Van Broeckhoven; Kristel Sleegers
Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.
Archives of neurology 2007;64(10):1436-46.
2007: Isabelle Le Ber; Julie van der Zee; Didier Hannequin; Ilse Gijselinck; Dominique Campion; Michèle Puel; Annie Laquerrière; Tim De Pooter; Agnès Camuzat; Marleen Van den Broeck; Bruno Dubois; François Sellal; Lucette Lacomblez; Martine Vercelletto; Catherine Thomas-Antérion; Bernard-François Michel; Véronique Golfier; Mira Didic; François Salachas; Charles Duyckaerts; Marc Cruts; Patrice Verpillat; Christine Van Broeckhoven; Alexis Brice
Progranulin null mutations in both sporadic and familial frontotemporal dementia.
Human mutation 2007;28(9):846-55.
2007: Julie van der Zee; Isabelle Le Ber; Sebastian Maurer-Stroh; Sebastiaan Engelborghs; Ilse Gijselinck; Agnès Camuzat; Nathalie Brouwers; Rik Vandenberghe; Kristel Sleegers; Didier Hannequin; Bart Dermaut; Joost Schymkowitz; Dominique Campion; Patrick Santens; Jean-Jacques Martin; Lucette Lacomblez; Tim De Pooter; Karin Peeters; Maria Mattheijssens; Martine Vercelletto; Marleen Van den Broeck; Marc Cruts; Peter Paul De Deyn; Frederic Rousseau; Alexis Brice; Christine Van Broeckhoven
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
Human mutation 2007;28(4):416.
2006: Jessie Theuns; Els Marjaux; Mathieu Vandenbulcke; K Van Laere; Samir Kumar-Singh; G Bormans; Nathalie Brouwers; Marleen Van den Broeck; Krist'l Vennekens; Ellen Corsmit; Marc Cruts; Bart De Strooper; Christine Van Broeckhoven; Rik Vandenberghe
Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment.
Human mutation 2006;27(9):888-96.
2006: Marc Cruts; Ilse Gijselinck; Julie van der Zee; Sebastiaan Engelborghs; Hans Wils; Daniel Pirici; Rosa Rademakers; Rik Vandenberghe; Bart Dermaut; Jean-Jacques Martin; C.M. Duijn; Karin Peeters; Raf Sciot; Patrick Santens; Tim De Pooter; Maria Mattheijssens; Marleen Van den Broeck; Ivy Cuijt; Krist'l Vennekens; Peter Paul De Deyn; Samir Kumar-Singh; Christine Van Broeckhoven
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
Nature 2006;442(7105):920-4.
2006: Julie van der Zee; Rosa Rademakers; Sebastiaan Engelborghs; Ilse Gijselinck; Veerle Bogaerts; Rik Vandenberghe; Patrick Santens; Jo Caekebeke; Tim De Pooter; Karin Peeters; Ursula Lübke; Marleen Van den Broeck; Jean-Jacques Martin; Marc Cruts; Peter Paul De Deyn; Christine Van Broeckhoven; Bart Dermaut
A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD.
Brain : a journal of neurology 2006;129(Pt 4):841-52.
2006: Sebastiaan Engelborghs; Bart Dermaut; Peter Mariën; Anoek Symons; Ellen Vloeberghs; Karen Maertens; Nore Somers; Johan Goeman; Rosa Rademakers; Marleen Van den Broeck; Barbara A Pickut; Marc Cruts; Christine Van Broeckhoven; Peter Paul De Deyn
Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia.
Neurobiology of aging 2006;27(2):285-92.
2005: Rosa Rademakers; Stacey Melquist; Marc Cruts; Jessie Theuns; Jurgen Del-Favero; Parvoneh Poorkaj-Navas; Matt Baker; Kristel Sleegers; Richard Crook; Tim De Pooter; Samira Bel Kacem; Jennifer Adamson; Dirk Van den Bossche; Marleen Van den Broeck; Jennifer Gass; Ellen Corsmit; Peter De Rijk; Natalie Thomas; Sebastiaan Engelborghs; Michael G Heckman; Irene Litvan; Julia Crook; Peter Paul De Deyn; dennis dickson; Gerard D Schellenberg; Christine Van Broeckhoven; Michael Hutton
High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy.
Human molecular genetics 2005;14(21):3281-92.
2005: Rosa Rademakers; Marc Cruts; Kristel Sleegers; Bart Dermaut; Jessie Theuns; Yurii Aulchenko; Stefan Weckx; Tim De Pooter; Marleen Van den Broeck; Ellen Corsmit; Peter De Rijk; Jurgen Del-Favero; John C van Swieten; C.M. Duijn; Christine Van Broeckhoven
Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample.
American journal of human genetics 2005;77(4):643-52.
2005: Rosa Rademakers; Kristel Sleegers; Jessie Theuns; Marleen Van den Broeck; Samira Bel Kacem; Lars-Göran Nilsson; Rolf Adolfsson; C.M. Duijn; Christine Van Broeckhoven; Marc Cruts
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.
Neurobiology of aging 2005;26(8):1145-51.
2004: Philippe Pals; Sarah J Lincoln; Jonathan Manning; Michael G Heckman; Lisa Skipper; Mary Hulihan; Marleen Van den Broeck; Tim De Pooter; Patrick Cras; Julia Crook; Christine Van Broeckhoven; Matthew J Farrer
alpha-Synuclein promoter confers susceptibility to Parkinson's disease.
Annals of neurology 2004;56(4):591-5.
2004: Esther A Croes; Jessie Theuns; Jeanine J Houwing-Duistermaat; Bart Dermaut; Kristel Sleegers; Gerwin Roks; Marleen Van den Broeck; B van Harten; John C van Swieten; Marc Cruts; Christine Van Broeckhoven; C.M. Duijn
Octapeptide repeat insertions in the prion protein gene and early onset dementia.
Journal of neurology, neurosurgery, and psychiatry 2004;75(8):1166-70.
2004: Seppo Helisalmi; Bart Dermaut; Mikko Hiltunen; Arto Mannermaa; Marleen Van den Broeck; Maarit Lehtovirta; Anne Maria Koivisto; Susan Iivonen; Marc Cruts; Hilkka Soininen; Christine Van Broeckhoven
Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.
Neurology 2004;63(1):173-5.
2004: Bart Dermaut; Samir Kumar-Singh; Sebastiaan Engelborghs; Jessie Theuns; Rosa Rademakers; Jos Saerens; Barbara A Pickut; Karin Peeters; Marleen Van den Broeck; Krist'l Vennekens; Stephan J Claes; Marc Cruts; Patrick Cras; Jean-Jacques Martin; Christine Van Broeckhoven; Peter Paul De Deyn
A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques.
Annals of neurology 2004;55(5):617-26.
2004: Rosa Rademakers; Marleen Van den Broeck; Kristel Sleegers; C.M. Duijn; Christine Van Broeckhoven; Marc Cruts
Absence of pathogenic mutations in presenilin homologue 2 in a conclusively 17-linked tau-negative dementia family.
Neurogenetics 2004;5(1):79-80.
2003: Marc Cruts; Bart Dermaut; Rosa Rademakers; Marleen Van den Broeck; Florian Stögbauer; Christine Van Broeckhoven
Novel APP mutation V715A associated with presenile Alzheimer's disease in a German family.
Journal of neurology 2003;250(11):1374-5.
2003: Esther A Croes; Bart Dermaut; Jeanine J Houwing-Duistermaat; Marleen Van den Broeck; Marc Cruts; Monique Breteler; Albert Hofman; Christine Van Broeckhoven; C.M. Duijn
Early cognitive decline is associated with prion protein codon 129 polymorphism.
Annals of neurology 2003;54(2):275-6.
2003: Sebastiaan Engelborghs; Bart Dermaut; Johan Goeman; Jos Saerens; Peter Mariën; Barbara A Pickut; Marleen Van den Broeck; Sally Serneels; Marc Cruts; Christine Van Broeckhoven; Peter Paul De Deyn
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects.
Journal of neurology, neurosurgery, and psychiatry 2003;74(8):1148-51.
2003: Bart Dermaut; Esther A Croes; Rosa Rademakers; Marleen Van den Broeck; Marc Cruts; Albert Hofman; C.M. Duijn; Christine Van Broeckhoven
PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.
Annals of neurology 2003;53(3):409-12.
2002: Bart Dermaut; Jessie Theuns; Kristel Sleegers; Hiroshi Hasegawa; Marleen Van den Broeck; Krist'l Vennekens; Ellen Corsmit; Peter St George-Hyslop; Marc Cruts; C.M. Duijn; Christine Van Broeckhoven
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample.
American journal of human genetics 2002;70(6):1568-74.
2002: Rosa Rademakers; Marc Cruts; Bart Dermaut; Kristel Sleegers; S M Rosso; Marleen Van den Broeck; Hubert Backhovens; John C van Swieten; C.M. Duijn; Christine Van Broeckhoven
Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval.
Molecular psychiatry 2002;7(10):1064-74.
2001: Marc Cruts; Bart Dermaut; Rosa Rademakers; Gerwin Roks; Marleen Van den Broeck; G Munteanu; C.M. Duijn; Christine Van Broeckhoven
Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease.
Neuroscience letters 2001;313(1-2):105-7.
2001: Jessie Theuns; Lars Feuk; Bart Dermaut; Jurgen Del-Favero; Gerwin Roks; Dirk Van den Bossche; Ellen Corsmit; Marleen Van den Broeck; C.M. Duijn; Marc Cruts; Anthony J Brookes; Christine Van Broeckhoven
The TNFRSF6 gene is not implicated in familial early-onset Alzheimer's disease.
Human genetics 2001;108(6):552-3.
2000: Jessie Theuns; Jurgen Del-Favero; Bart Dermaut; C.M. Duijn; Hubert Backhovens; Marleen Van den Broeck; Sally Serneels; Ellen Corsmit; Christine Van Broeckhoven; Marc Cruts
Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression.
Human molecular genetics 2000;9(3):325-31.
1999: C.M. Duijn; Marc Cruts; Jessie Theuns; G Van Gassen; Hubert Backhovens; Marleen Van den Broeck; A Wehnert; Sally Serneels; Albert Hofman; Christine Van Broeckhoven
Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample.
European journal of human genetics : EJHG 1999;7(7):801-6.
1998: Marc Cruts; C.M. Duijn; Hubert Backhovens; Marleen Van den Broeck; A Wehnert; Sally Serneels; R Sherrington; Michael Hutton; John Hardy; Peter St George-Hyslop; Albert Hofman; Christine Van Broeckhoven
Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease.
Human molecular genetics 1998;7(1):43-51.
1997: Marjolijn Bornebroek; Joost Haan; Hubert Backhovens; P Deutz; Mark A Van Buchem; Marleen Van den Broeck; Egbert Bakker; Raymund A C Roos; Christine Van Broeckhoven
Presenilin-1 polymorphism and hereditary cerebral hemorrhage with amyloidosis, Dutch type.
Annals of neurology 1997;42(1):108-10.
1997: Stephan J Claes; Petra Raeymaekers; Marleen Van den Broeck; S Diependaele; A De bruyn; Greta Verheyen; V Wils; Andrea Boogaerts; An Tanghe; Jan Godderis; Christine Van Broeckhoven; Jean-Jacques Cassiman
A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder.
Journal of affective disorders 1997;43(3):195-205.