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Philippe Van den Steen

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Katrien Deroost; Chris J Janse; Mina Komuta; Natacha Lays; Jing-Wen Lin; Sam Noppen; Ghislain Opdenakker; Ana Pamplona; Mauro Prato; Tania Roskams; Evelin Schwarzer; Ariane Tyberghein; Paolo Arese; Dirk Daelemans; Els Vanstreels; Philippe E Van den Steen
Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome.
Jennifer Vandooren; Philippe E Van den Steen; Nathalie Geurts; Erik Martens; Ghislain Opdenakker
Zymography methods for visualizing hydrolytic enzymes.
Nathalie Geurts; Erik Martens; Paul Proost; Walter Stöcker; Philippe E Van den Steen; Christoph Becker-Pauly; Ghislain Opdenakker
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.

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2013: Katrien Deroost; Chris J Janse; Mina Komuta; Natacha Lays; Jing-Wen Lin; Sam Noppen; Ghislain Opdenakker; Ana Pamplona; Mauro Prato; Tania Roskams; Evelin Schwarzer; Ariane Tyberghein; Paolo Arese; Dirk Daelemans; Els Vanstreels; Philippe E Van den Steen
Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome.
American journal of respiratory cell and molecular biology 2013;48(5):589-600.
2013: Jennifer Vandooren; Philippe E Van den Steen; Nathalie Geurts; Erik Martens; Ghislain Opdenakker
Zymography methods for visualizing hydrolytic enzymes.
Nature methods 2013;10(3):211-20.
2012: Nathalie Geurts; Erik Martens; Paul Proost; Walter Stöcker; Philippe E Van den Steen; Christoph Becker-Pauly; Ghislain Opdenakker
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3.
FEBS letters 2012;586(24):4264-9.
2012: Diego Sbardella; Francesca Sciandra; Philippe E Van den Steen; Andrea Brancaccio; Massimo Castagnola; Massimo Coletta; Bruno Giardina; Magda Gioia; Federica Iavarone; Rosanna Inzitari; Stefano Marini; Ghislain Opdenakker; Manuela Bozzi
Enzymatic processing by MMP-2 and MMP-9 of wild-type and mutated mouse β-dystroglycan.
IUBMB life 2012;64(12):988-94.
2012: Zheng Qiu; Philippe E Van den Steen; Jialiang Hu; Ghislain Opdenakker
Targeting matrix metalloproteinases in acute inflammatory shock syndromes.
Combinatorial chemistry & high throughput screening 2012;15(7):555-70.
2012: Zheng Qiu; Philippe E Van den Steen; Min Wang; Ming Yan; Qian Li; Datao Liu; Ghislain Opdenakker; Jialiang Hu
Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-α converting enzyme (TACE/ADAM-17).
Journal of enzyme inhibition and medicinal chemistry 2012;27(4):533-40.
2012: Nathalie Geurts; Ghislain Opdenakker; Philippe E Van den Steen
Matrix metalloproteinases as therapeutic targets in protozoan parasitic infections.
Pharmacology & therapeutics 2012;133(3):257-79.
2012: Katrien Deroost; Natacha Lays; Erik Martens; Sam Noppen; Ghislain Opdenakker; Philippe E Van den Steen
Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice.
Malaria journal 2012;11():166.
2011: Mauro Prato; Donatella Taramelli; Philippe E Van den Steen; Paolo Arese; Sarah D'Alessandro; Ghislain Opdenakker; Nicoletta Basilico
Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium.
Cellular microbiology 2011;13(8):1275-85.
2011: Bénédicte Cauwe; Erik Martens; Xavier Sagaert; Chris Dillen; Nathalie Geurts; Sandra Li; Jan Mertens; Greet Thijs; Philippe E Van den Steen; Hubertine Heremans; Rita De Vos; Daniel Blockmans; Bernd Arnold; Ghislain Opdenakker
Deficiency of gelatinase B/MMP-9 aggravates lpr-induced lymphoproliferation and lupus-like systemic autoimmune disease.
Journal of autoimmunity 2011;36(3-4):239-52.
2011: Jennifer Vandooren; Nathalie Geurts; Erik Martens; Philippe E Van den Steen; Steven De Jonghe; Piet Herdewijn; Ghislain Opdenakker
Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain.
World journal of biological chemistry 2011;2(1):14-24.
2011: Philippe E Van den Steen; J Van Damme; K Deroost; N Geurts; H Heremans; G Opdenakker
Malaria: host-pathogen interactions, immunopathological complications and therapy.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2011;73(1-2):123-51.
2011: Nathalie Geurts; Hubertine Heremans; Natacha Lays; Sandra Li; Stefan Magez; Erik Martens; Ghislain Opdenakker; Greet Thijs; Bénédicte Cauwe; Sebastien Verhenne; Philippe E Van den Steen
Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice.
PloS one 2011;6(11):e27131.
2010: Jan De Munck; Atsushi Mine; Philippe E Van den Steen; Kirsten Van Landuyt; André Poitevin; Ghislain Opdenakker; Bart Van Meerbeek
Enzymatic degradation of adhesive-dentin interfaces produced by mild self-etch adhesives.
European journal of oral sciences 2010;118(5):494-501.
2010: Philippe E Van den Steen; Nathalie Geurts; Katrien Deroost; Ilse Van Aelst; Sebastien Verhenne; Hubertine Heremans; Jo Van Damme; Ghislain Opdenakker
Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome.
American journal of respiratory and critical care medicine 2010;181(9):957-68.
2010: Javier Redondo-Muñoz; Estefanía Ugarte-Berzal; María José Terol; Philippe E Van den Steen; Mercedes Hernández del Cerro; Martin Roderfeld; Elke Roeb; Ghislain Opdenakker; José A García-Marco; Angeles García-Pardo
Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain.
Cancer cell 2010;17(2):160-72.
2010: Gabriel Rosenblum; Philippe E Van den Steen; Sidney R Cohen; Arkady Bitler; David Douglass Brand; Ghislain Opdenakker; Irit Sagi
Direct visualization of protease action on collagen triple helical structure.
PloS one 2010;5(6):e11043.
2009: Veronica C Ardi; Philippe E Van den Steen; Ghislain Opdenakker; Bernhard Schweighofer; Elena I Deryugina; James P Quigley
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.
The Journal of biological chemistry 2009;284(38):25854-66.
2009: Helene Piccard; Jialiang Hu; Pierre Fiten; Paul Proost; Erik Martens; Philippe E Van den Steen; Jo Van Damme; Ghislain Opdenakker
"Reverse degradomics", monitoring of proteolytic trimming by multi-CE and confocal detection of fluorescent substrates and reaction products.
Electrophoresis 2009;30(13):2366-77.
2009: Magda Gioia; Susanna Monaco; Philippe E Van den Steen; Diego Sbardella; Giuseppe Grasso; Stefano Marini; Christopher M Overall; Ghislain Opdenakker; Massimo Coletta
The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B.
Journal of molecular biology 2009;386(2):419-34.
2008: Armando M De Palma; Erik Verbeken; Ilse Van Aelst; Philippe E Van den Steen; Ghislain Opdenakker; Johan Neyts
Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.
Virology 2008;382(1):20-7.
2008: Sandra Li; Erik Martens; Chris Dillen; Philippe E Van den Steen; Ghislain Opdenakker
Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C).
Biochemical pharmacology 2008;76(7):831-40.
2008: Bénédicte Cauwe; Ellen Martens; Philippe E Van den Steen; Paul Proost; Ilse Van Aelst; Daniel Blockmans; Ghislain Opdenakker
Adenylyl cyclase-associated protein-1/CAP1 as a biological target substrate of gelatinase B/MMP-9.
Experimental cell research 2008;314(15):2739-49.
2008: Javier Redondo-Muñoz; Estefanía Ugarte-Berzal; José A García-Marco; Mercedes Hernández del Cerro; Philippe E Van den Steen; Ghislain Opdenakker; María José Terol; Angeles García-Pardo
Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells.
Blood 2008;112(1):169-78.
2008: Philippe E Van den Steen; Katrien Deroost; Ilse Van Aelst; Nathalie Geurts; Erik Martens; Sofie Struyf; Catherine Q Nie; Diana Hansen; Patrick Matthys; Jo Van Damme; Ghislain Opdenakker
CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-gamma-induced chemokines.
European journal of immunology 2008;38(4):1082-95.
2008: Nathalie Geurts; Erik Martens; Ilse Van Aelst; Paul Proost; Ghislain Opdenakker; Philippe E Van den Steen
Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3.
Biochemistry 2008;47(8):2689-99.
2008: M E Muroski; M D Roycik; Robert G Newcomer; Philippe E Van den Steen; G Opdenakker; H R Monroe; Z J Sahab; Qing-Xiang Amy Sang
Matrix metalloproteinase-9/gelatinase B is a putative therapeutic target of chronic obstructive pulmonary disease and multiple sclerosis.
Current pharmaceutical biotechnology 2008;9(1):34-46.
2007: Gabriel Rosenblum; Philippe E Van den Steen; Sidney R Cohen; J Günter Grossmann; Jessica Frenkel; Rotem Sertchook; Nelle L Slack; Richard W Strange; Ghislain Opdenakker; Irit Sagi
Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B.
Structure (London, England : 1993) 2007;15(10):1227-36.
2007: Jialiang Hu; Philippe E Van den Steen; Qing-Xiang A Sang; Ghislain Opdenakker
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.
Nature reviews. Drug discovery 2007;6(6):480-98.
2007: Bénédicte Cauwe; Philippe E Van den Steen; Ghislain Opdenakker
The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.
Critical reviews in biochemistry and molecular biology 2007;42(3):113-85.
2007: Helene Piccard; Philippe E Van den Steen; Ghislain Opdenakker
Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins.
Journal of leukocyte biology 2007;81(4):870-92.
2007: Ahmed M Abu El-Asrar; Philippe E Van den Steen; Saleh A Al-Amro; Luc Missotten; Ghislain Opdenakker; Karel Geboes
Expression of angiogenic and fibrogenic factors in proliferative vitreoretinal disorders.
International ophthalmology 2007;27(1):11-22.
2007: Erik Martens; An Leyssen; Ilse Van Aelst; Pierre Fiten; Helene Piccard; Jialiang Hu; Francis J Descamps; Philippe E Van den Steen; Paul Proost; Jo Van Damme; Grazia Maria Liuzzi; Paolo Riccio; Eugenia Polverini; Ghislain Opdenakker
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains.
Biochimica et biophysica acta 2007;1770(2):178-86.
2006: Simon A Fry; Philippe E Van den Steen; Louise Royle; Mark R Wormald; Anthony J Leathem; Ghislain Opdenakker; James M McDonnell; Raymond A Dwek; Pauline M Rudd
Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.
Biochemistry 2006;45(51):15249-58.
2006: Jialiang Hu; Véronique Dubois; Patrick Chaltin; Pierre Fiten; Chris Dillen; Philippe E Van den Steen; Ghislain Opdenakker
Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library.
Combinatorial chemistry & high throughput screening 2006;9(8):599-611.
2006: Philippe E Van den Steen; Ilse Van Aelst; Sofie Starckx; Klaus Maskos; Ghislain Opdenakker; Axel Pagenstecher
Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria.
Laboratory investigation; a journal of technical methods and pathology 2006;86(9):873-88.
2006: Philippe E Van den Steen; Ilse Van Aelst; Vibeke Hvidberg; Helene Piccard; Pierre Fiten; Christian Jacobsen; Søren K Moestrup; Simon Fry; Louise Royle; Mark R Wormald; Russell Wallis; Pauline M Rudd; Raymond A Dwek; Ghislain Opdenakker
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.
The Journal of biological chemistry 2006;281(27):18626-37.
2006: Ghislain Opdenakker; Chris Dillen; Pierre Fiten; Erik Martens; Ilse Van Aelst; Philippe E Van den Steen; Inge Nelissen; Sofie Starckx; Francis J Descamps; Jialiang Hu; Helene Piccard; Jo Van Damme; Mark R Wormald; Pauline M Rudd; Raymond A Dwek
Remnant epitopes, autoimmunity and glycosylation.
Biochimica et biophysica acta 2006;1760(4):610-5.
2005: Jialiang Hu; Philippe E Van den Steen; Chris Dillen; Ghislain Opdenakker
Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock.
Biochemical pharmacology 2005;70(4):535-44.
2005: Jialiang Hu; Pierre Fiten; Philippe E Van den Steen; Patrick Chaltin; Ghislain Opdenakker
Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform.
Analytical chemistry 2005;77(7):2116-24.
2005: Simon A Fry; Philippe E Van den Steen; Louise Royle; Mark R Wormald; Anthony J Leathem; Ghislain Opdenakker; Pauline M Rudd; Raymond A Dwek
Differential glycosylation of gelatinase B from neutrophils and breast cancer cells.
Advances in experimental medicine and biology 2005;564():103-12.
2005: Philippe E Van den Steen; Bernard Grillet; Ghislain Opdenakker
Gelatinase B participates in collagen II degradation and releases glycosylated remnant epitopes in rheumatoid arthritis.
Advances in experimental medicine and biology 2005;564():45-55.
2005: Francis J Descamps; Erik Martens; Paul Proost; Sofie Starckx; Philippe E Van den Steen; Jo Van Damme; Ghislain Opdenakker
Gelatinase B/matrix metalloproteinase-9 provokes cataract by cleaving lens betaB1 crystallin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):29-35.
2004: Philippe E Van den Steen; Paul Proost; David Douglass Brand; Andrew H Kang; Jo Van Damme; Ghislain Opdenakker
Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.
Biochemistry 2004;43(33):10809-16.
2004: Jialiang Hu; Philippe E Van den Steen; Michel Houde; T Toney Ilenchuk; Ghislain Opdenakker
Inhibitors of gelatinase B/matrix metalloproteinase-9 activity comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody.
Biochemical pharmacology 2004;67(5):1001-9.
2003: Philippe E Van den Steen; Steven J Husson; Paul Proost; Jo Van Damme; Ghislain Opdenakker
Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase.
Biochemical and biophysical research communications 2003;310(3):889-96.
2003: Philippe E Van den Steen; Anja Wuyts; Steven J Husson; Paul Proost; Jo Van Damme; Ghislain Opdenakker
Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.
European journal of biochemistry / FEBS 2003;270(18):3739-49.
2003: Sofie Starckx; Philippe E Van den Steen; Richard Verbeek; Johannes M van Noort; Ghislain Opdenakker
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.
Journal of neuroimmunology 2003;141(1-2):47-57.
2003: Inge Nelissen; Erik Martens; Philippe E Van den Steen; Paul Proost; Isabelle Ronsse; Ghislain Opdenakker
Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy.
Brain : a journal of neurology 2003;126(Pt 6):1371-81.
2003: Francis J Descamps; Philippe E Van den Steen; Erik Martens; Florence Ballaux; Karel Geboes; Ghislain Opdenakker
Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(8):887-9.
2003: Ghislain Opdenakker; Philippe E Van den Steen; Geneviève Laureys; Kathleen Hunninck; Bernd Arnold
Neutralizing antibodies in gene-defective hosts.
Trends in immunology 2003;24(2):94-100.
2003: Francis J Descamps; Philippe E Van den Steen; Inge Nelissen; Jo Van Damme; Ghislain Opdenakker
Remnant epitopes generate autoimmunity: from rheumatoid arthritis and multiple sclerosis to diabetes.
Advances in experimental medicine and biology 2003;535():69-77.
2002: Philippe E Van den Steen; Bénédicte Dubois; Inge Nelissen; Pauline M Rudd; Raymond A Dwek; Ghislain Opdenakker
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9).
Critical reviews in biochemistry and molecular biology 2002;37(6):375-536.
2002: Philippe E Van den Steen; Paul Proost; Bernard Grillet; David Douglass Brand; Andrew H Kang; Jo Van Damme; Ghislain Opdenakker
Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):379-89.
2002: Sofie Starckx; Philippe E Van den Steen; Anja Wuyts; Jo Van Damme; Ghislain Opdenakker
Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization.
Leukemia & lymphoma 2002;43(2):233-41.
2001: Philippe E Van den Steen; Ghislain Opdenakker; Mark R Wormald; R A Dwek; P M Rudd
Matrix remodelling enzymes, the protease cascade and glycosylation.
Biochimica et biophysica acta 2001;1528(2-3):61-73.
2001: Ghislain Opdenakker; Philippe E Van den Steen; J Van Damme
Gelatinase B: a tuner and amplifier of immune functions.
Trends in immunology 2001;22(10):571-9.
2001: Ghislain Opdenakker; Philippe E Van den Steen; Bénédicte Dubois; Inge Nelissen; Els Van Coillie; S Masure; Paul Proost; Jo Van Damme
Gelatinase B functions as regulator and effector in leukocyte biology.
Journal of leukocyte biology 2001;69(6):851-9.
2000: Taj S Mattu; Louise Royle; J Langridge; Mark R Wormald; Philippe E Van den Steen; Jo Van Damme; Ghislain Opdenakker; David Harvey; Raymond A Dwek; Pauline M Rudd
O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme.
Biochemistry 2000;39(51):15695-704.
2000: Oded Kleifeld; Philippe E Van den Steen; Anatoly I Frenkel; F Cheng; H L Jiang; Ghislain Opdenakker; Irit Sagi
Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils.
The Journal of biological chemistry 2000;275(44):34335-43.
2000: Philippe E Van den Steen; Paul Proost; Anja Wuyts; Jo Van Damme; Ghislain Opdenakker
Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.
Blood 2000;96(8):2673-81.
1999: Pauline M Rudd; Taj S Mattu; S Masure; T Bratt; Philippe E Van den Steen; Mark R Wormald; B Küster; David Harvey; Niels Borregaard; Jo Van Damme; Raymond A Dwek; Ghislain Opdenakker
Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.
Biochemistry 1999;38(42):13937-50.
1998: Philippe E Van den Steen; Pauline M Rudd; Paul Proost; Erik Martens; L Paemen; B Küster; Jo Van Damme; Raymond A Dwek; Ghislain Opdenakker
Oligosaccharides of recombinant mouse gelatinase B variants.
Biochimica et biophysica acta 1998;1425(3):587-98.
1998: Philippe E Van den Steen; Pauline M Rudd; Raymond A Dwek; Ghislain Opdenakker
Concepts and principles of O-linked glycosylation.
Critical reviews in biochemistry and molecular biology 1998;33(3):151-208.
1998: Philippe E Van den Steen; Pauline M Rudd; Raymond A Dwek; Jo Van Damme; Ghislain Opdenakker
Cytokine and protease glycosylation as a regulatory mechanism in inflammation and autoimmunity.
Advances in experimental medicine and biology 1998;435():133-43.
1989: K P Heirwegh; J A Meuwissen; Philippe E Van den Steen; Humbert De Smedt
Modelling of chemical reactions catalysed by membrane-bound enzymes. Determination and significance of the kinetic constants.
Biochimica et biophysica acta 1989;995(2):151-9.