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Gijsbertus van der Horst

Research Profile

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Physiology

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Circadian Rhythm

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Johanna L Barclay; Olaf Jöhren; Dominic Landgraf; Alexei Leliavski; Helge Müller-Fielitz; Nadine Naujokat; Anton Shostak; Anthony H Tsang; Gijsbertus T J van der Horst; Henrik Oster
High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.
Utham K Valekunja; Gijsbertus T J van der Horst; Filippo Tamanini; Daniel J Turner; Rachel S Edgar; Malgorzata Oklejewicz; John S O'Neill; Akhilesh B Reddy
Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.
Erik Engelen; Roel C Janssens; Veronique A J Smits; Gijsbertus T J van der Horst; Kazuhiro Yagita; Filippo Tamanini
Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.

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2013: Johanna L Barclay; Olaf Jöhren; Dominic Landgraf; Alexei Leliavski; Helge Müller-Fielitz; Nadine Naujokat; Anton Shostak; Anthony H Tsang; Gijsbertus T J van der Horst; Henrik Oster
High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.
American journal of physiology. Endocrinology and metabolism 2013;304(10):E1053-63.
2013: Utham K Valekunja; Gijsbertus T J van der Horst; Filippo Tamanini; Daniel J Turner; Rachel S Edgar; Malgorzata Oklejewicz; John S O'Neill; Akhilesh B Reddy
Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(4):1554-9.
2013: Erik Engelen; Roel C Janssens; Veronique A J Smits; Gijsbertus T J van der Horst; Kazuhiro Yagita; Filippo Tamanini
Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.
PloS one 2013;8(2):e56623.
2012: Eleonora Parlanti; Gijsbertus T J van der Horst; Ingrid van der Pluijm; Andrea Zijno; Denis S F Biard; Angelo Calcagnile; Paolo Degan; Mariarosaria D'Errico; Eugenia Dogliotti
The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells.
Free radical biology & medicine 2012;53(11):2171-7.
2012: Marieke van de Ven; Gijsbertus T J van der Horst; Jaan-Olle Andressoo; Jan H J Hoeijmakers; James R Mitchell
Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models.
DNA repair 2012;11(11):874-83.
2012: Karin E M Diderich; Jan H J Hoeijmakers; Claudia Nicolaije; Matthias Priemel; Arndt F Schilling; Gijsbertus T J van der Horst; Sander M Botter; Renata M C Brandt; Judd S Day; Jan H Waarsing; Harrie Weinans; Johannes P T M van Leeuwen
Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice.
Age (Dordrecht, Netherlands) 2012;34(4):845-61.
2012: Jeroen T Buijs; H Cheung; B de Rooij; J Kroon; Rob C M Pelger; M Petersen; C van den Hoogen; Gijsbertus T J van der Horst; Petra G M van Overveld; Gabri van der Pluijm
The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation.
Oncogene 2012;31(17):2164-74.
2012: Magdalena A Biernat; Andre P M Eker; Gijsbertus T J van der Horst; Monique M van Oers; Just M Vlak; Inês Chaves
A baculovirus photolyase with DNA repair activity and circadian clock regulatory function.
Journal of biological rhythms 2012;27(1):3-11.
2012: Claudia Nicolaije; Matthias Priemel; Arndt F Schilling; B C J van der Eerden; Gijsbertus T J van der Horst; S M Botter; Renata M C Brandt; Judd S Day; Karin E M Diderich; Jan H J Hoeijmakers; Jan H Waarsing; Harrie Weinans; Johannes P T M van Leeuwen
Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice.
PloS one 2012;7(4):e35246.
2011: Nils Z Borgesius; Monique C de Waard; Jan H J Hoeijmakers; Dick Jaarsma; David W Melton; Azar Omrani; Gijsbertus T J van der Horst; Ingrid van der Pluijm; Gerben C M Zondag; Ype Elgersma
Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(35):12543-53.
2011: Gijsbertus T J van der Horst; Roland Blanque; Henny Bloys; Jeroen T Buijs; Henry Cheung; Philippe Clément-Lacroix; Jean Feyen; Bertrand Heckmann; Giocondo Lorenzon; Rob C M Pelger; Philippe Pujuguet; Christel van den Hoogen; Gabri van der Pluijm
Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer.
Neoplasia (New York, N.Y.) 2011;13(6):516-25.
2011: Inês Chaves; Richard Pokorny; Martin Byrdin; Nathalie Hoang; Thorsten Ritz; Klaus Brettel; Lars-Oliver Essen; Gijsbertus T J van der Horst; Alfred Batschauer; Margaret Ahmad
The cryptochromes: blue light photoreceptors in plants and animals.
Annual review of plant biology 2011;62():335-64.
2011: Inês Chaves; António Carvalho da Silva; Andre P M Eker; Romana M Nijman; Shoko Saito; Monika I Bajek; Magdalena A Biernat; Karl Brand; Kazuhiro Yagita; Gijsbertus T J van der Horst
The Potorous CPD photolyase rescues a cryptochrome-deficient mammalian circadian clock.
PloS one 2011;6(8):e23447.
2010: Markus Stratmann; Frédéric Stadler; Filippo Tamanini; Gijsbertus T J van der Horst; Juergen Ripperger
Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1.
Genes & development 2010;24(12):1317-28.
2010: Kuo-Yu Huang; Suzanna A de Groot; Henri Woelders; Gijsbertus T J van der Horst; Axel P N Themmen; Ben Colenbrander; J Martje Fentener van Vlissingen
Functionality of cryopreserved juvenile ovaries from mutant mice in different genetic background strains after allotransplantation.
Cryobiology 2010;60(2):129-37.
2010: M Petersen; Evangelia Pardali; Gijsbertus T J van der Horst; H Cheung; C van den Hoogen; G van der Pluijm; Peter ten Dijke
Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis.
Oncogene 2010;29(9):1351-61.
2010: York Kamenisch; Maria Fousteri; Jennifer Knoch; Anna-Katharina von Thaler; Birgit Fehrenbacher; Hiroki Kato; Thomas Becker; Martijn E T Dollé; Raoul Kuiper; Marc Majora; Martin Schaller; Gijsbertus T J van der Horst; Harry van Steeg; Martin Röcken; Doron Rapaport; Jean Krutmann; Leon H Mullenders; Mark Berneburg
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging.
The Journal of experimental medicine 2010;207(2):379-90.
2010: Masao Doi; Yukari Takahashi; Rie Komatsu; Fumiyoshi Yamazaki; Hiroyuki Yamada; Shogo Haraguchi; Noriaki Emoto; Yasushi Okuno; Gozoh Tsujimoto; Akihiro Kanematsu; Osamu Ogawa; Takeshi Todo; Kazuyoshi Tsutsui; Gijsbertus T J van der Horst; Hitoshi Okamura
Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.
Nature medicine 2010;16(1):67-74.
2009: Eugin Destici; Malgorzata Oklejewicz; Romana Nijman; Filippo Tamanini; Gijsbertus T J van der Horst
Impact of the circadian clock on in vitro genotoxic risk assessment assays.
Mutation research 2009;680(1-2):87-94.
2009: Joris Pothof; Nicole S Verkaik; Wilfred van IJcken; Erik A C Wiemer; Van T B Ta; Gijsbertus T J van der Horst; Nicolaas G J Jaspers; Dik C van Gent; Jan H J Hoeijmakers; Stephan P Persengiev
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.
The EMBO journal 2009;28(14):2090-9.
2009: Yoichi Minami; Takeya Kasukawa; Yuji Kakazu; Masayuki Iigo; Masahiro Sugimoto; Satsuki Ikeda; Akira Yasui; Gijsbertus T J van der Horst; Tomoyoshi Soga; Hiroki R Ueda
Measurement of internal body time by blood metabolomics.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9890-5.
2009: george garinis; Lieneke M Uittenboogaard; Heike Stachelscheid; Maria Fousteri; Wilfred van Ijcken; Timo M Breit; Harry van Steeg; Leon H F Mullenders; Gijsbertus T J van der Horst; Jens C Brüning; Carien M Niessen; Jan H J Hoeijmakers; Björn Schumacher
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.
Nature cell biology 2009;11(5):604-15.
2009: Isabelle M Bur; Anne M Cohen-Solal; Danielle Carmignac; Pierre-Yves Abecassis; Norbert Chauvet; Agnès O Martin; Gijsbertus T J van der Horst; Iain C A F Robinson; Patrick Maurel; Patrice Mollard; Xavier Bonnefont
The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism.
The Journal of biological chemistry 2009;284(14):9066-73.
2009: Jaan-Olle Andressoo; Geert Weeda; Jan de Wit; James R Mitchell; Rudolf B Beems; Harry van Steeg; Gijsbertus T J van der Horst; Jan H Hoeijmakers
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Molecular and cellular biology 2009;29(5):1276-90.
2008: Morven A Cameron; Alun R Barnard; Roelof Hut; Xavier Bonnefont; Gijsbertus T J van der Horst; Mark W Hankins; Robert J Lucas
Electroretinography of wild-type and Cry mutant mice reveals circadian tuning of photopic and mesopic retinal responses.
Journal of biological rhythms 2008;23(6):489-501.
2008: George A Garinis; Gijsbertus T J van der Horst; Jan Vijg; Jan H J Hoeijmakers
DNA damage and ageing: new-age ideas for an age-old problem.
Nature cell biology 2008;10(11):1241-7.
2008: Harm de Waard; Edwin Sonneveld; Jan de Wit; Rebecca Esveldt-van Lange; Jan H J Hoeijmakers; Harry Vrieling; Gijsbertus T J van der Horst
Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.
DNA repair 2008;7(10):1659-69.
2008: Joost P M Melis; Susan W P Wijnhoven; Rudolf B Beems; Marianne Roodbergen; Jolanda van den Berg; Hojin Moon; Errol Friedberg; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Jan Vijg; Harry van Steeg
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.
Cancer research 2008;68(5):1347-53.
2008: Malgorzata Oklejewicz; Eugin Destici; Filippo Tamanini; Roelof Hut; Roel Janssens; Gijsbertus T J van der Horst
Phase resetting of the mammalian circadian clock by DNA damage.
Current biology : CB 2008;18(4):286-91.
2008: Sato Honma; Tsubura Yasuda; Akira Yasui; Gijsbertus T J van der Horst; Ken-ichi Honma
Circadian behavioral rhythms in Cry1/Cry2 double-deficient mice induced by methamphetamine.
Journal of biological rhythms 2008;23(1):91-4.
2008: Björn Schumacher; Ingrid van der Pluijm; Michael J Moorhouse; Theodore Kosteas; Andria Rasile Robinson; Yousin Suh; Timo M Breit; Harry van Steeg; Laura J Niedernhofer; Wilfred van Ijcken; Andrzej Bartke; Stephen R Spindler; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; George A Garinis
Delayed and accelerated aging share common longevity assurance mechanisms.
PLoS genetics 2008;4(8):e1000161.
2008: Jung Yoon Park; Mi-Ook Cho; Shanique Leonard; Brent Calder; I Saira Mian; Woo Ho Kim; Susan Wijnhoven; Harry van Steeg; James Mitchell; Gijsbertus T J van der Horst; Jan Hoeijmakers; Pinchas Cohen; Jan Vijg; Yousin Suh
Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.
PloS one 2008;3(6):e2346.
2007: Irene C Notting; Jeroen T Buijs; Ratna Mintardjo; Gijsbertus T J van der Horst; Slobodan Vukicevic; Clemens Lowik; Nicoline E Schalij-Delfos; Jan E E Keunen; Gabri van der Pluijm
Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo.
Investigative ophthalmology & visual science 2007;48(11):4882-9.
2007: Jeroen T Buijs; Nico Henriquez; Petra G M van Overveld; Gijsbertus T J van der Horst; Ivo Que; Ruth Schwaninger; Cyrill Rentsch; Peter ten Dijke; Anne-Marie Cleton-Jansen; Keltouma Driouch; Rosette Lidereau; Richard Bachelier; Slobodan Vukicevic; Philippe Clézardin; Socrates E Papapoulos; Marco G Cecchini; Clemens W G M Löwik; Gabri van der Pluijm
Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer.
Cancer research 2007;67(18):8742-51.
2007: Jeroen T Buijs; Cyrill Rentsch; Gijsbertus T J van der Horst; Petra G M van Overveld; Antoinette Wetterwald; Ruth Schwaninger; Nico Henriquez; Peter ten Dijke; Fran Borovecki; Regula Markwalder; George N Thalmann; Socrates E Papapoulos; Rob C M Pelger; Slobodan Vukicevic; Marco G Cecchini; Clemens W G M Löwik; Gabri van der Pluijm
BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo.
The American journal of pathology 2007;171(3):1047-57.
2007: Vladimira Jakubcakova; Henrik Oster; Filippo Tamanini; Cristina Cadenas; Michael Leitges; Gijsbertus T J van der Horst; Gregor Eichele
Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism.
Neuron 2007;54(5):831-43.
2007: Hideki Bando; Takeshi Nishio; Gijsbertus T J van der Horst; Satoru Masubuchi; Yasuo Hisa; Hitoshi Okamura
Vagal regulation of respiratory clocks in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(16):4359-65.
2007: Theo G M F Gorgels; Ingrid van der Pluijm; Renata M C Brandt; george garinis; Harry van Steeg; Gerard van den Aardweg; Gerard H Jansen; Jan M Ruijter; Arthur A B Bergen; Dirk van Norren; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome.
Molecular and cellular biology 2007;27(4):1433-41.
2007: Susan W P Wijnhoven; Esther M Hoogervorst; Harm de Waard; Gijsbertus T J van der Horst; Harry van Steeg
Tissue specific mutagenic and carcinogenic responses in NER defective mouse models.
Mutation research 2007;614(1-2):77-94.
2007: Filippo Tamanini; Inês Chaves; M I Bajek; Gijsbertus T J van der Horst
Structure function analysis of mammalian cryptochromes.
Cold Spring Harbor symposia on quantitative biology 2007;72():133-9.
2007: Jeroen T Buijs; Nico Henriquez; Petra G M van Overveld; Gijsbertus T J van der Horst; Peter ten Dijke; Gabri van der Pluijm
TGF-beta and BMP7 interactions in tumour progression and bone metastasis.
Clinical & experimental metastasis 2007;24(8):609-17.
2007: Ingrid van der Pluijm; george garinis; Renata M C Brandt; Theo G M F Gorgels; Susan W P Wijnhoven; Karin E M Diderich; Jan de Wit; James R Mitchell; Conny Th M van Oostrom; Rudolf B Beems; Laura J Niedernhofer; Susana Velasco; Errol C Friedberg; Kiyoji Tanaka; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
PLoS biology 2007;5(1):e2.
2007: Ruth Schwaninger; Cyrill Rentsch; Antoinette Wetterwald; Gijsbertus T J van der Horst; Rutger L van Bezooijen; Gabri van der Pluijm; Clemens W G M Löwik; Karin Ackermann; Walter Pyerin; Freddie C Hamdy; George N Thalmann; Marco G Cecchini
Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases.
The American journal of pathology 2007;170(1):160-75.
2007: Rutger L van Bezooijen; J Peter Svensson; Daniel Eefting; Annemieke Visser; Gijsbertus T J van der Horst; Marcel Karperien; Paul H A Quax; Harry Vrieling; Socrates E Papapoulos; Peter ten Dijke; Clemens W G M Löwik
Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(1):19-28.
2006: Laura J Niedernhofer; george garinis; Anja Raams; Astrid S Lalai; Andria Rasile Robinson; Esther Appeldoorn; Hanny Odijk; Roos Oostendorp; Anwaar Ahmad; Wibeke J van Leeuwen; Arjan F Theil; Wim Vermeulen; Gijsbertus T J van der Horst; Peter Meinecke; Wim J Kleijer; Jan Vijg; Nicolaas G J Jaspers; Jan H J Hoeijmakers
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
Nature 2006;444(7122):1038-43.
2006: Marieke van de Ven; Jaan-Olle Andressoo; Valerie B Holcomb; Marieke von Lindern; Willeke M C Jong; Chris I De Zeeuw; Yousin Suh; Edward Hasty; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; James R Mitchell
Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.
PLoS genetics 2006;2(12):e192.
2006: Eric L Kaijzel; Marcel Karperien; Gijsbertus T J van der Horst; Gabri van der Pluijm; Clemens Lowik; Alan Chan
Cell-based and molecular imaging tools for validating new therapies in the treatment of bone metabolic disorders and metastases.
Current opinion in molecular therapeutics 2006;8(6):477-9.
2006: Judith Jans; george garinis; Wouter Schul; Adri van Oudenaren; Michael J Moorhouse; Marcel Smid; Yurda-Gul Sert; Albertina van der Velde; Yvonne Rijksen; Frank R de Gruijl; Peter van der Spek; Akira Yasui; Jan H J Hoeijmakers; Pieter J M Leenen; Gijsbertus T J van der Horst
Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.
Molecular and cellular biology 2006;26(22):8515-26.
2006: Jaan-Olle Andressoo; Judith Jans; Jan de Wit; Frédéric Coin; Deborah Hoogstraten; Marieke van de Ven; Wendy Toussaint; Jan G M Huijmans; H Bing Thio; Wibeke J van Leeuwen; Jan de Boer; Jean-Marc Egly; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; James R Mitchell
Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.
PLoS biology 2006;4(10):e322.
2006: Jaan-Olle Andressoo; James R Mitchell; Jan de Wit; Deborah Hoogstraten; Marcel Volker; Wendy Toussaint; Ewoud Speksnijder; Rudolf B Beems; Harry van Steeg; Judith Jans; Chris I De Zeeuw; Nicolaas G J Jaspers; Anja Raams; Alan Lehmann; Wim Vermeulen; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.
Cancer cell 2006;10(2):121-32.
2006: Yota B Kiyohara; Sayaka Tagao; Filippo Tamanini; Akira Morita; Yukiko Sugisawa; Maya Yasuda; Iori Yamanaka; Hiroki R Ueda; Gijsbertus T J van der Horst; Takao Kondo; Kazuhiro Yagita
The BMAL1 C terminus regulates the circadian transcription feedback loop.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):10074-9.
2006: Martijn E T Dollé; Rita A Busuttil; Ana Maria Garcia; Susan W P Wijnhoven; Ellen van Drunen; Laura J Niedernhofer; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Harry van Steeg; Jan Vijg
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.
Mutation research 2006;596(1-2):22-35.
2006: george garinis; Judith Jans; Gijsbertus T J van der Horst
Photolyases: capturing the light to battle skin cancer.
Future oncology (London, England) 2006;2(2):191-9.
2006: Inês Chaves; Kazuhiro Yagita; Sander Barnhoorn; Hitoshi Okamura; Gijsbertus T J van der Horst; Filippo Tamanini
Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.
Molecular and cellular biology 2006;26(5):1743-53.
2005: Gijsbertus T J van der Horst; Hetty Farih-Sips; Clemens W G M Löwik; Marcel Karperien
Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 Cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(12):2233-44.
2005: Claude Backendorf; Jan de Wit; Marijke van Oosten; Gerdine J Stout; James R Mitchell; Anne-Marijke Borgstein; Gijsbertus T J van der Horst; Frank R de Gruijl; Jaap Brouwer; Leon H F Mullenders; Jan H J Hoeijmakers
Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice.
DNA repair 2005;4(11):1325-36.
2005: Susan W P Wijnhoven; Rudolf B Beems; Marianne Roodbergen; Jolanda van den Berg; Paul H M Lohman; Karin Diderich; Gijsbertus T J van der Horst; Jan Vijg; Jan H J Hoeijmakers; Harry van Steeg
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction.
DNA repair 2005;4(11):1314-24.
2005: george garinis; James R Mitchell; Michael J Moorhouse; Katsuhiro Hanada; Harm de Waard; Dimitri Vandeputte; Judith Jans; Karl Brand; Marcel Smid; Peter van der Spek; Jan H J Hoeijmakers; Roland Kanaar; Gijsbertus T J van der Horst
Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks.
The EMBO journal 2005;24(22):3952-62.
2005: Gijsbertus T J van der Horst; Steffie M van der Werf; Hetty Farih-Sips; Rutger L van Bezooijen; Clemens W G M Löwik; Marcel Karperien
Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(10):1867-77.
2005: Huiling Xu; Matthew D Beasley; William D Warren; Gijsbertus T J van der Horst; Michael McKay
Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis.
Developmental cell 2005;8(6):949-61.
2005: Michihiko Iijima; Shun Yamaguchi; Gijsbertus T J van der Horst; Xavier Bonnefont; Hitoshi Okamura; Shigenobu Shibata
Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice.
Neuroscience research 2005;52(2):166-73.
2005: Irene C Notting; Jeroen T Buijs; Ivo Que; Ratna Mintardjo; Gijsbertus T J van der Horst; Marcel Karperien; Guy S Missotten; Martine J Jager; Nicoline E Schalij-Delfos; Jan E E Keunen; Gabri van der Pluijm
Whole-body bioluminescent imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis.
Investigative ophthalmology & visual science 2005;46(5):1581-7.
2005: Mohammad Saifur Rohman; Noriaki Emoto; Hidemi Nonaka; Ryusuke Okura; MASATAKA NISHIMURA; Kazuhiro Yagita; Gijsbertus T J van der Horst; Masafumi Matsuo; Hitoshi Okamura; Mitsuhiro Yokoyama
Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney.
Kidney international 2005;67(4):1410-9.
2005: Judith Jans; Wouter Schul; Yurda-Gul Sert; Yvonne Rijksen; Heggert Rebel; Andre P M Eker; Satoshi Nakajima; Harry van Steeg; Frank R de Gruijl; Akira Yasui; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Powerful skin cancer protection by a CPD-photolyase transgene.
Current biology : CB 2005;15(2):105-15.
2005: Filippo Tamanini; Kazuhiro Yagita; Hitoshi Okamura; Gijsbertus T J van der Horst
Nucleocytoplasmic shuttling of clock proteins.
Methods in enzymology 2005;393():418-35.
2004: Kamiel Spoelstra; Urs Albrecht; Gijsbertus T J van der Horst; Verena Brauer; Serge Daan
Phase responses to light pulses in mice lacking functional per or cry genes.
Journal of biological rhythms 2004;19(6):518-29.
2004: Yuki Okuda; Ryotaro Nishi; Jessica M Y Ng; Wim Vermeulen; Gijsbertus T J van der Horst; Toshio Mori; Jan H J Hoeijmakers; Fumio Hanaoka; Kaoru Sugasawa
Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.
DNA repair 2004;3(10):1285-95.
2004: Harm de Waard; Jan de Wit; Jaan-Olle Andressoo; Conny Th M van Oostrom; Bente Riis; Allan Weimann; Henrik E Poulsen; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.
Molecular and cellular biology 2004;24(18):7941-8.
2003: Teruya Tamaru; Yasushi Isojima; Gijsbertus T J van der Horst; Kohtaro Takei; Katsuya Nagai; Ken Takamatsu
Nucleocytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibroblasts.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(12):973-83.
2003: Gijsbertus T J van der Horst; Hetty Farih-Sips; Clemens W G M Löwik; Marcel Karperien
Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells.
Bone 2003;33(6):899-910.
2003: Wendy Kölgen; Harry van Steeg; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Willem A van Vloten; Frank R de Gruijl; Johan Garssen
Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.
The Journal of investigative dermatology 2003;121(4):751-6.
2003: Henrik Oster; Gijsbertus T J van der Horst; Urs Albrecht
Daily variation of clock output gene activation in behaviorally arrhythmic mPer/mCry triple mutant mice.
Chronobiology international 2003;20(4):683-95.
2003: Jessica M Y Ng; Wim Vermeulen; Gijsbertus T J van der Horst; Steven Bergink; Kaoru Sugasawa; Harry Vrieling; Jan H J Hoeijmakers
A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.
Genes & development 2003;17(13):1630-45.
2003: Henrik Oster; Stephanie Baeriswyl; Gijsbertus T J van der Horst; Urs Albrecht
Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.
Genes & development 2003;17(11):1366-79.
2003: Mitsugu Sujino; Koh-hei Masumoto; Shun Yamaguchi; Gijsbertus T J van der Horst; Hitoshi Okamura; Shin-Ichi T Inouye
Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrhythmic mice.
Current biology : CB 2003;13(8):664-8.
2003: Hirokazu Takahashi; Nanae Umeda; Yoko Tsutsumi; Ryutaro Fukumura; Hajime Ohkaze; Mitsugu Sujino; Gijsbertus T J van der Horst; Akira Yasui; Shin-Ichi T Inouye; Akira Fujimori; Tatsuya Ohhata; Ryoko Araki; Masumi Abe
Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus.
Brain research. Molecular brain research 2003;110(1):1-6.
2003: Harm de Waard; Jan de Wit; Theo G M F Gorgels; Gerard van den Aardweg; Jaan-Olle Andressoo; Marcel Vermeij; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice.
DNA repair 2003;2(1):13-25.
2003: Xavier Bonnefont; Henk Albus; Johanna H Meijer; Gijsbertus T J van der Horst
Light signalling in cryptochrome-deficient mice.
Novartis Foundation symposium 2003;253():56-66; discussion 66-72, 102-9.
2002: Tinna Stevnsner; Simon G Nyaga; Nadja C de Souza-Pinto; Gijsbertus T J van der Horst; Theo G M F Gorgels; Barbara A Hogue; Tina Thorslund; Vilhelm A Bohr
Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B.
Oncogene 2002;21(57):8675-82.
2002: Gijsbertus T J van der Horst; Rutger L van Bezooijen; Martine M L Deckers; Jakomijn Hoogendam; Annemieke Visser; Clemens W G M Löwik; Marcel Karperien
Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation.
Bone 2002;31(6):661-9.
2002: Marcel Osterod; Elisabeth Larsen; Florence Le Page; Jan G Hengstler; Gijsbertus T J van der Horst; Serge Boiteux; Arne Klungland; Bernd Epe
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage.
Oncogene 2002;21(54):8232-9.
2002: Masashi Takao; Shin-ichiro Kanno; Kumiko Kobayashi; Qiu-Mei Zhang; Shuji Yonei; Gijsbertus T J van der Horst; Akira Yasui
A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.
The Journal of biological chemistry 2002;277(44):42205-13.
2002: Henrik Oster; Akira Yasui; Gijsbertus T J van der Horst; Urs Albrecht
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice.
Genes & development 2002;16(20):2633-8.
2002: Wouter Schul; Judith Jans; Yvonne Rijksen; Kyra H M Klemann; Andre P M Eker; Jan de Wit; Osamu Nikaido; Satoshi Nakajima; Akira Yasui; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice.
The EMBO journal 2002;21(17):4719-29.
2002: Henk Albus; Xavier Bonnefont; Inês Chaves; Akira Yasui; Judith Doczy; Gijsbertus T J van der Horst; Johanna H Meijer
Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei.
Current biology : CB 2002;12(13):1130-3.
2002: Masashi Takao; Shin-ichiro Kanno; Tatsuya Shiromoto; Rei Hasegawa; Hiroshi Ide; Shogo Ikeda; Altaf H Sarker; Shuji Seki; James Z Xing; X Chris Le; Michael Weinfeld; Kumiko Kobayashi; Jun-ichi Miyazaki; Manja Muijtjens; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; Akira Yasui; Altraf H Sarker
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.
The EMBO journal 2002;21(13):3486-93.
2002: Jan de Boer; Jaan-Olle Andressoo; Jan de Wit; Jan G M Huijmans; Rudolf B Beems; Harry van Steeg; Geert Weeda; Gijsbertus T J van der Horst; Wibeke J van Leeuwen; Axel P N Themmen; Morteza Meradji; Jan H J Hoeijmakers
Premature aging in mice deficient in DNA repair and transcription.
Science (New York, N.Y.) 2002;296(5571):1276-9.
2002: Martine M L Deckers; Rutger L van Bezooijen; Gijsbertus T J van der Horst; Jakomijn Hoogendam; Chris van Der Bent; Socrates E Papapoulos; Clemens W G M Löwik
Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A.
Endocrinology 2002;143(4):1545-53.
2002: Kazuhiro Yagita; Filippo Tamanini; Maya Yasuda; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; Hitoshi Okamura
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.
The EMBO journal 2002;21(6):1301-14.
2002: Gijsbertus T J van der Horst; Lisiane Meira; Theo G M F Gorgels; Jan de Wit; Susana Velasco-Miguel; James A Richardson; Yvonne Kamp; Maaike P G Vreeswijk; Bep Smit; Dirk Bootsma; Jan H J Hoeijmakers; Errol C Friedberg
UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.
DNA repair 2002;1(2):143-57.
2002: Jessica M Y Ng; Harry Vrieling; Kaoru Sugasawa; Marja Ooms; J Anton Grootegoed; Jan Vreeburg; Pim Visser; Rudolf B Beems; Theo G M F Gorgels; Fumio Hanaoka; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B.
Molecular and cellular biology 2002;22(4):1233-45.
2001: Douglas E Brash; Norbert Wikonkál; Eva Remenyik; Gijsbertus T J van der Horst; E C Friedberg; D L Cheo; Harry van Steeg; Anja Westerman; Henk J van Kranen
The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.
The Journal of investigative dermatology 2001;117(5):1234-40.
2001: A Boonstra; Adri van Oudenaren; Miranda Baert; Harry van Steeg; Pieter J M Leenen; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Huub F J Savelkoul; Johan Garssen
Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSB DNA repair-deficient mice.
The Journal of investigative dermatology 2001;117(1):141-6.
2001: Kazuhiro Yagita; Filippo Tamanini; Gijsbertus T J van der Horst; Hitoshi Okamura
Molecular mechanisms of the biological clock in cultured fibroblasts.
Science (New York, N.Y.) 2001;292(5515):278-81.
2001: Serge Daan; U Albrecht; Gijsbertus T J van der Horst; H Illnerová; Till Roenneberg; Thomas Wehr; William J Schwartz
Assembling a clock for all seasons: are there M and E oscillators in the genes?
Journal of biological rhythms 2001;16(2):105-16.
2001: Shun Yamaguchi; Masaki Kobayashi; Shigeru Mitsui; Yoshiki Ishida; Gijsbertus T J van der Horst; M Suzuki; Shigenobu Shibata; Hitoshi Okamura
View of a mouse clock gene ticking.
Nature 2001;409(6821):684.
2000: Susan W P Wijnhoven; Hanneke Kool; Conny Th M van Oostrom; Rudolf B Beems; Leon H F Mullenders; Albert A van Zeeland; Gijsbertus T J van der Horst; Harry Vrieling; Harry van Steeg
The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B mice.
Cancer research 2000;60(20):5681-7.
2000: Susan W P Wijnhoven; Hanneke Kool; Leon H F Mullenders; Albert A van Zeeland; Errol C Friedberg; Gijsbertus T J van der Horst; Harry van Steeg; Harry Vrieling
Age-dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair.
Oncogene 2000;19(43):5034-7.
2000: Marijke van Oosten; Heggert Rebel; Errol C Friedberg; Harry van Steeg; Gijsbertus T J van der Horst; Henk J van Kranen; Anja Westerman; Albert A van Zeeland; Leon H F Mullenders; Frank R de Gruijl
Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11268-73.
2000: Johan Garssen; Harry van Steeg; Frank R de Gruijl; Jan de Boer; Gijsbertus T J van der Horst; Henk J van Kranen; Henk Van Loveren; M Van Dijk; A Fluitman; Geert Weeda; Jan H J Hoeijmakers
Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6199-205.
2000: Rob J W Berg; Heggert Rebel; Gijsbertus T J van der Horst; Henk J van Kranen; Leon H F Mullenders; Willem A van Vloten; Frank R de Gruijl
Impact of global genome repair versus transcription-coupled repair on ultraviolet carcinogenesis in hairless mice.
Cancer research 2000;60(11):2858-63.
2000: Kazuhiro Yagita; Shun Yamaguchi; Filippo Tamanini; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Akira Yasui; Jennifer J Loros; Jay C Dunlap; Hitoshi Okamura
Dimerization and nuclear entry of mPER proteins in mammalian cells.
Genes & development 2000;14(11):1353-63.
2000: LP Shearman; S Sriram; David R Weaver; Elizabeth S Maywood; Inês Chaves; B Zheng; K Kume; C C Lee; Gijsbertus T J van der Horst; Michael H Hastings; Steven M Reppert
Interacting molecular loops in the mammalian circadian clock.
Science (New York, N.Y.) 2000;288(5468):1013-9.
1999: Hitoshi Okamura; S Miyake; Yasuo Sumi; Shun Yamaguchi; Akira Yasui; Manja Muijtjens; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock.
Science (New York, N.Y.) 1999;286(5449):2531-4.
1999: Jan de Boer; Gijsbertus T J van der Horst; Jan H J Hoeijmakers
[Mutant mice as a model of human diseases of aging. Defective transcription and premature aging].
Tijdschrift voor gerontologie en geriatrie 1999;30(4):168-70.
1999: Jan de Boer; Harry van Steeg; Rob J W Berg; Johan Garssen; Jan de Wit; C T van Oostrum; Rudolf B Beems; Gijsbertus T J van der Horst; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers; Geert Weeda
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
Cancer research 1999;59(14):3489-94.
1999: Gijsbertus T J van der Horst; Manja Muijtjens; Kumiko Kobayashi; R Takano; Shin-ichiro Kanno; Masashi Takao; Jan de Wit; A Verkerk; Andre P M Eker; Dik van Leenen; R Buijs; Dirk Bootsma; Jan H J Hoeijmakers; Akira Yasui
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.
Nature 1999;398(6728):627-30.
1998: Kumiko Kobayashi; Shin-ichiro Kanno; B Smit; Gijsbertus T J van der Horst; Masashi Takao; Akira Yasui
Characterization of photolyase/blue-light receptor homologs in mouse and human cells.
Nucleic acids research 1998;26(22):5086-92.
1998: Elisabetta Citterio; Suzanne Rademakers; Gijsbertus T J van der Horst; Alain van Gool; Jan H J Hoeijmakers; Wim Vermeulen
Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein.
The Journal of biological chemistry 1998;273(19):11844-51.
1998: Geert Weeda; Jan de Boer; I Donker; Jan de Wit; S B Winkler; Gijsbertus T J van der Horst; Wim Vermeulen; Dirk Bootsma; Jan H J Hoeijmakers
Molecular basis of DNA repair mechanisms and syndromes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():147-55.
1997: Alain van Gool; Gijsbertus T J van der Horst; Elisabetta Citterio; Jan H J Hoeijmakers
Cockayne syndrome: defective repair of transcription?
The EMBO journal 1997;16(14):4155-62.
1997: Gijsbertus T J van der Horst; Harry van Steeg; Rob J W Berg; Alain van Gool; Jan de Wit; Geert Weeda; Hans Morreau; Rudolf B Beems; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.
Cell 1997;89(3):425-35.
1997: Wim Vermeulen; Jan de Boer; Elisabetta Citterio; Alain van Gool; Gijsbertus T J van der Horst; Nicolaas G J Jaspers; Wouter de Laat; AM Sijbers; Peter van der Spek; Kaoru Sugasawa; Geert Weeda; GS Winkler; Dirk Bootsma; Jean-Marc Egly; Jan H J Hoeijmakers
Mammalian nucleotide excision repair and syndromes.
Biochemical Society transactions 1997;25(1):309-15.
1992: R Fingerhut; Gijsbertus T J van der Horst; Frans W Verheijen; Ernst Conzelmann
Degradation of gangliosides by the lysosomal sialidase requires an activator protein.
European journal of biochemistry / FEBS 1992;208(3):623-9.
1990: Gijsbertus T J van der Horst; U Rose; Reinhard Brossmer; Frans W Verheijen
Photoaffinity labeling of the lysosomal neuraminidase from bovine testis.
FEBS letters 1990;277(1-2):42-4.
1990: Gijsbertus T J van der Horst; Grazia M S Mancini; Reinhard Brossmer; U Rose; Frans W Verheijen
Photoaffinity labeling of a bacterial sialidase with an aryl azide derivative of sialic acid.
The Journal of biological chemistry 1990;265(19):10801-4.
1989: Hans Morreau; Niels Galjart; Nynke Gillemans; Rob Willemsen; Gijsbertus T J van der Horst; Alessandra d'Azzo
Alternative splicing of beta-galactosidase mRNA generates the classic lysosomal enzyme and a beta-galactosidase-related protein.
The Journal of biological chemistry 1989;264(34):20655-63.
1989: Gijsbertus T J van der Horst; Niels Galjart; Alessandra d'Azzo; H Galjaard; Frans W Verheijen
Identification and in vitro reconstitution of lysosomal neuraminidase from human placenta.
The Journal of biological chemistry 1989;264(2):1317-22.
1988: Niels Galjart; Nynke Gillemans; A Harris; Gijsbertus T J van der Horst; Frans W Verheijen; H Galjaard; Alessandra d'Azzo
Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases.
Cell 1988;54(6):755-64.